n-desmethylclobazam has been researched along with clobazam in 56 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (37.50) | 18.7374 |
| 1990's | 8 (14.29) | 18.2507 |
| 2000's | 7 (12.50) | 29.6817 |
| 2010's | 18 (32.14) | 24.3611 |
| 2020's | 2 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Berry, DJ; Newbery, JE; Streete, JM | 1 |
| Bardy, AH; Granström, ML; Salokorpi, T; Santavuori, P; Seppälä, T | 1 |
| Löscher, W; Rundfeldt, C | 1 |
| Blaschuk, K; Couture, M; Guberman, A; Sherwin, A | 1 |
| Bun, H; Cano, JP; Durand, A; Monjanel-Mouterde, S; Noel, F | 1 |
| Filipek, M; Gaździk, WR; Podleśny, J | 1 |
| Badcock, NR; Zoanetti, GD | 1 |
| Feely, M; Garratt, JC; Gent, JP; Haigh, JR; Pullar, T | 1 |
| Feely, MP; Haigh, JR; Peaker, S; Pullar, T | 1 |
| Edwards, D; Feely, MP; Haigh, JR; Peaker, S; Pullar, T | 1 |
| Dusci, LJ; Hackett, LP | 1 |
| Bun, H; Cano, JP; Coassolo, P; Gouezo, F; Serradimigni, A | 1 |
| Arranz Peña, MI; Sanenz Lope, E | 1 |
| Dailley, C; Feely, M; Gent, JP; Haigh, JR; Pullar, T | 1 |
| Aubert, C; Bun, H; Cano, JP; Coassolo, P; Tomasini, JL | 1 |
| Caccia, S; Garattini, S; Guiso, G | 1 |
| Greenblatt, DJ; Lüttkenhorst, M; Ochs, HR; Verburg-Ochs, B | 1 |
| Koeppen, D; Laux, G | 1 |
| Calvert, R; Gent, JP; Haigh, JR | 1 |
| Goldberg, V; Lascelles, PT; Ratnaraj, N | 1 |
| Jawad, S; Oxley, J; Richens, A | 1 |
| Grigoleit, HG; Hajdú, P; Hundt, HK; Koeppen, D; Malerczyk, V; Meyer, BH; Müller, FO; Witte, PU | 1 |
| Ciraulo, DA; Divoll, M; Greenblatt, DJ; Ho, I; Puri, SK; Shader, RI | 1 |
| Challier, JC; Chavinie, J; de Lauture, D; Francoual, C; Guerre-Millo, M; Helou, A; Nandakumaran, M; Olive, G; Rey, E | 1 |
| Brachet-Liermain, A; Faure, O; Guyot, M; Jarry, C; Loiseau, P | 1 |
| Ballabio, M; Caccia, S; Garattini, S; Guiso, G; Zanini, MG | 1 |
| LeGatt, DF; McIntosh, DP | 1 |
| Nakamura, F; Nishimura, S; Seino, M; Suzuki, S; Yagi, K | 1 |
| Akerman, KK | 1 |
| Kunicki, PK | 1 |
| Giovanardi-Rossi, P; Parmeggiani, A; Posar, A; Sangiorgi, S | 1 |
| Marques, EP; Pinheiro, J; Proença, P; Teixeira, H; Vieira, DN | 1 |
| Kosaki, K; Samejima, H; Sato, R; Takahashi, T; Tamura, K; Tanigawara, Y | 1 |
| Ardakani, YH; Badri, G; Hakemi, L; Mokhberi, M; Rouini, M | 1 |
| Aylett, SE; Berry, D; Cross, H | 1 |
| Begum, T; Ikeda, A; Kinoshita, M; Shibasaki, H; Terada, K | 1 |
| Charpenel-Durat, C; De Meo, P; De Saint Léger, MN; Duval, ML; Kuhlmann, E; Mauras, M; Navarette, C; Pok, PR | 1 |
| de Leon, J; Diaz, FJ; Spina, E | 1 |
| Ikeda, H; Imai, K; Inoue, Y; Kagawa, Y; Kasai, R; Matsuda, K; Miyakawa, K; Mogami, Y; Nishimura, S; Takahashi, Y; Takayama, R; Terada, K; Yamaguchi, T; Yamamoto, Y | 1 |
| Ishitsu, T; Kaneko, S; Nagata, R; Nakagawa, K; Nakashima, H; Nishimura, M; Ogusu, N; Saruwatari, J; Seo, T; Shimomasuda, M; Tanikawa, K; Tsuda, Y; Yasui-Furukori, N | 1 |
| Ebert, B; Jensen, HS; Lee, D; Nichol, K | 1 |
| Aarons, L; Ogungbenro, K | 1 |
| Barrios, L; Chopineaux, D; Clément, R; Dailly, É; Gaulier, JM; Monteil-Ganiere, C; Pineau, A | 1 |
| Chhun, S; Chiron, C; Dulac, O; Jullien, V; Pons, G; Rey, E; Tod, M | 1 |
| Ebert, B; Hammer, H; Jensen, AA; Jensen, HS | 1 |
| Bruno, PL; Geffrey, AL; Pollack, SF; Thiele, EA | 1 |
| Bekersky, I; Chu, HM; Ette, EI; Tolbert, D | 1 |
| Baftiu, A; Burns, ML; Johannessen, SI; Landmark, CJ; Opdal, MS | 1 |
| Acuña, MA; Benke, D; Besson, M; Daali, Y; Desmeules, J; Matthey, A; Ralvenius, WT; Rudolph, U; Zeilhofer, HU | 1 |
| Ishida, T; Ishii, M; Iwasaki, T; Nonoda, Y; Toki, T | 1 |
| Bebin, EM; Cutter, GR; Gaston, TE; Liu, Y; Szaflarski, JP | 1 |
| Bekersky, I; Gordon, J; Harris, S; Reid, S; Tolbert, D; Walzer, M | 1 |
| Appleton, R; Devinsky, O; Greenwood, S; Harden, CL; Morrison, G; Patel, AD; Sommerville, K; Thiele, EA; Wong, MH | 1 |
| Phelps, SJ; Russell, GR; Shelton, CM; Wheless, JW | 1 |
| Aleksanyan, A; Armoudjian, Y; Gevorgyan, A; Harutyunyan, A; Margaryan, T; Mikayelyan, A; Sargsyan, M; Zakaryan, H; Zhamharyan, L | 1 |
| Bjørnvold, M; Burns, ML; Heger, K; Johannessen Landmark, C; Johannessen, SI; Lund, C; Sætre, E | 1 |
1 review(s) available for n-desmethylclobazam and clobazam
| Article | Year |
|---|---|
Clobazam therapeutic drug monitoring: a comprehensive review of the literature with proposals to improve future studies.
Topics: Animals; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Benzodiazepines; Clobazam; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Monitoring; Humans; Intellectual Disability; Lennox Gastaut Syndrome; Spasms, Infantile | 2013 |
8 trial(s) available for n-desmethylclobazam and clobazam
| Article | Year |
|---|---|
Add-on trial of clobazam in intractable adult epilepsy with plasma level correlations.
Topics: Adult; Aged; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Dose-Response Relationship, Drug; Epilepsy; Humans; Middle Aged; Seizures | 1990 |
Pharmacokinetics of N-desmethylclobazam in healthy volunteers and patients with epilepsy.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Epilepsy; Female; Humans; Male | 1987 |
The effect of cimetidine on the single dose pharmacokinetics of oral clobazam and N-desmethylclobazam.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Biological Availability; Cimetidine; Clobazam; Female; Half-Life; Humans; Kinetics; Male | 1987 |
Simultaneous determination of clobazam and its major metabolite in human plasma by a rapid HPLC method.
Topics: Anticonvulsants; Area Under Curve; Benzodiazepines; Biological Availability; Chromatography, High Pressure Liquid; Clobazam; Cross-Over Studies; Double-Blind Method; Half-Life; Humans; Reproducibility of Results | 2005 |
Efficacy of low-dose, add-on therapy of clobazam (CLB) is produced by its major metabolite, N-desmethyl-CLB.
Topics: Adult; Anticonvulsants; Benzodiazepines; Clobazam; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Treatment Outcome | 2007 |
Drug-metabolism mechanism: Knowledge-based population pharmacokinetic approach for characterizing clobazam drug-drug interactions.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Biological Availability; Child; Child, Preschool; Clobazam; Cytochrome P-450 CYP2C19 Inducers; Cytochrome P-450 CYP2C19 Inhibitors; Cytochrome P-450 CYP3A Inducers; Drug Interactions; Female; Humans; Lennox Gastaut Syndrome; Male; Middle Aged; Models, Biological; Young Adult | 2016 |
A Thorough QT/QTc Study of Clobazam in Healthy Volunteers.
Topics: Adult; Anticonvulsants; Benzodiazepines; Clobazam; Cytochrome P-450 CYP2C19; Double-Blind Method; Female; Fluoroquinolones; Healthy Volunteers; Heart Rate; Humans; Male; Moxifloxacin | 2017 |
Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome.
Topics: Anticonvulsants; Benzodiazepines; Cannabidiol; Child; Child, Preschool; Clobazam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Epilepsies, Myoclonic; Follow-Up Studies; Humans; Treatment Outcome | 2018 |
47 other study(ies) available for n-desmethylclobazam and clobazam
| Article | Year |
|---|---|
The analysis of clobazam and its metabolite desmethylclobazam by high-performance liquid chromatography.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Chromatography, High Pressure Liquid; Clobazam; Drug Stability; Humans | 1991 |
Monitoring of concentrations of clobazam and norclobazam in serum and saliva of children with epilepsy.
Topics: Adolescent; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child; Child, Preschool; Chromatography, Gas; Clobazam; Drug Tolerance; Epilepsy; Female; Humans; Infant; Male; Saliva | 1991 |
Development of tolerance to clobazam in fully kindled rats: effects of intermittent flumazenil administration.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Clobazam; Drug Tolerance; Electric Stimulation; Electrodes, Implanted; Female; Flumazenil; Half-Life; Hypnotics and Sedatives; Injections, Intraperitoneal; Kindling, Neurologic; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1990 |
Effects of age and antiepileptic drugs on plasma levels and kinetics of clobazam and N-desmethylclobazam.
Topics: Adolescent; Adult; Age Factors; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Child; Child, Preschool; Clobazam; Drug Therapy, Combination; Epilepsy; Humans; Infant; Phenobarbital; Phenytoin; Time Factors; Valproic Acid | 1990 |
HPLC method for simultaneous determination of clobazam and N-desmethylclobazam in human serum, rat serum and rat brain homogenates.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Brain Chemistry; Chromatography, High Pressure Liquid; Clobazam; Humans; Rats; Spectrophotometry, Ultraviolet | 1989 |
Micro-determination of clobazam and N-desmethylclobazam in plasma or serum by electron-capture gas chromatography.
Topics: Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Chromatography, Gas; Clobazam; Drug Stability; Electrochemistry; Humans; Indicators and Reagents | 1987 |
Disappointing results of increasing benzodiazepine dose after the development of anticonvulsant tolerance.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Middle Aged | 1988 |
Simultaneous determination of clobazam, N-desmethyl clobazam and clonazepam in plasma by high performance liquid chromatography.
Topics: Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Chromatography, High Pressure Liquid; Clobazam; Clonazepam; Humans; Spectrophotometry, Ultraviolet | 1987 |
Time-dependence of clobazam and N-demethylclobazam kinetics in healthy volunteers.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Biotransformation; Clobazam; Half-Life; Humans; Kinetics | 1986 |
Determination of clobazam and its N-demethyl metabolite in serum of epileptic patients.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Chromatography, Gas; Clobazam; Epilepsy; Humans | 1986 |
N-desmethylclobazam: a possible alternative to clobazam in the treatment of refractory epilepsy?
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Drug Resistance; Female; Humans; Male; Middle Aged | 1987 |
Determination of clobazam, N-desmethylclobazam and their hydroxy metabolites in plasma and urine by high-performance liquid chromatography.
Topics: Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Chromatography, High Pressure Liquid; Clobazam; Humans; Hydroxylation | 1985 |
Brain concentrations of clobazam and N-desmethylclobazam and antileptazol activity.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Brain Chemistry; Clobazam; Male; Mice; Pentylenetetrazole; Rats | 1980 |
Single and multiple dose kinetics of clobazam, and clinical effects during multiple dosage.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clobazam; Consciousness; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Time Factors | 1984 |
Serum and cerebrospinal fluid concentration of clobazam and N-desmethylclobazam.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Biotransformation; Clobazam; Female; Humans; Kinetics; Male; Nervous System Diseases | 1984 |
Plasma concentrations of clobazam and its N-desmethyl metabolite; protection against pentetrazol-induced convulsions in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Injections, Subcutaneous; Male; Mice; Pentylenetetrazole; Seizures | 1984 |
Determination of clobazam and desmethylclobazam in serum using high-performance liquid chromatography.
Topics: Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Chromatography, High Pressure Liquid; Clobazam; Humans | 1984 |
Single dose pharmacokinetic study of clobazam in normal volunteers and epileptic patients.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Clobazam; Enzyme Induction; Epilepsy; Female; Humans; Kinetics; Male; Phenytoin | 1984 |
Pharmacokinetic aspects of the interaction between clobazam and cimetidine.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Biotransformation; Cimetidine; Clobazam; Drug Interactions; Half-Life; Humans; Kinetics; Male; Models, Biological | 1983 |
Clobazam kinetics: intrasubject variability and effect of food on adsorption.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clobazam; Food; Humans; Intestinal Absorption; Kinetics; Male; Time Factors | 1982 |
Materno-Fetal placental transfer of clobazam and norclobazam in late gestation.
Topics: Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clobazam; Delivery, Obstetric; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Pregnancy Trimester, Third; Time Factors | 1982 |
Liquid chromatography determination of clobazam and its major metabolite N-desmethylclobazam in human plasma.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Biological Availability; Chromatography, High Pressure Liquid; Clobazam; Humans; Kinetics; Spectrophotometry, Ultraviolet | 1982 |
Antileptazol activity and kinetics of clobazam and N-desmethyl-clobazam in the guinea-pig.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Brain; Clobazam; Guinea Pigs; Half-Life; Kinetics; Male; Pentylenetetrazole; Species Specificity; Time Factors | 1981 |
Clobazam and norclobazam quantitation in serum by capillary gas chromatography with electron-capture detection.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Chromatography, Gas; Clobazam; Humans; Reference Standards; Reproducibility of Results | 1993 |
Effects of clobazam and its active metabolite on GABA-activated currents in rat cerebral neurons in culture.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Cells, Cultured; Cerebral Cortex; Chloride Channels; Clobazam; Dose-Response Relationship, Drug; Epilepsy; Flumazenil; gamma-Aminobutyric Acid; Humans; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, GABA; Synaptic Transmission | 1996 |
Analysis of clobazam and its active metabolite norclobazam in plasma and serum using HPLC/DAD.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Chromatography, High Pressure Liquid; Clobazam; Humans; Sensitivity and Specificity | 1996 |
Simple and sensitive high-performance liquid chromatographic method for the determination of 1,5-benzodiazepine clobazam and its active metabolite N-desmethylclobazam in human serum and urine with application to 1,4-benzodiazepines analysis.
Topics: Anti-Anxiety Agents; Benzodiazepines; Calibration; Chromatography, High Pressure Liquid; Clobazam; Humans; Reproducibility of Results; Sensitivity and Specificity | 2001 |
Unusual side-effects due to clobazam: a case report with genetic study of CYP2C19.
Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Benzodiazepines; Child; Clobazam; Cytochrome P-450 CYP2C19; Dyssomnias; Electroencephalography; Enuresis; Epilepsy; Female; Humans; Mixed Function Oxygenases; Mutation | 2004 |
Forensic intoxication with clobazam: HPLC/DAD/MSD analysis.
Topics: Anticonvulsants; Benzodiazepines; Bronchopneumonia; Chromatography, High Pressure Liquid; Clobazam; Female; Forensic Medicine; Humans; Mass Spectrometry; Middle Aged; Molecular Structure | 2004 |
A major influence of CYP2C19 genotype on the steady-state concentration of N-desmethylclobazam.
Topics: Adolescent; Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Benzodiazepines; Child; Child, Preschool; Clobazam; Cytochrome P-450 CYP2C19; DNA Mutational Analysis; Dose-Response Relationship, Drug; Drug Resistance; Epilepsy; Female; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Genotype; Humans; Infant; Japan; Male; Metabolic Clearance Rate; Mixed Function Oxygenases; Mutation; Phenotype; Polymorphism, Genetic | 2004 |
Eye rolling as a manifestation of clobazam toxicity in a child with epilepsy.
Topics: Anticonvulsants; Benzodiazepines; Child, Preschool; Clobazam; Dose-Response Relationship, Drug; Epilepsy; Humans; Lamotrigine; Male; Ocular Motility Disorders; Treatment Outcome; Triazines | 2006 |
Blood concentrations of clobazam and norclobazam in a lethal case involving clobazam, meprobamate and clorazepate.
Topics: Aged; Anticonvulsants; Autopsy; Benzodiazepines; Clobazam; Clorazepate Dipotassium; Drug Overdose; Fatal Outcome; Female; Humans; Meprobamate | 2010 |
Influence of CYP2C19 polymorphism and concomitant antiepileptic drugs on serum clobazam and N-desmethyl clobazam concentrations in patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asian People; Benzodiazepines; Clobazam; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Humans; Japan; Male; Phenotype; Polymorphism, Genetic; Regression Analysis; Sensitivity and Specificity; Young Adult | 2013 |
Effects of CYP2C19 and P450 oxidoreductase polymorphisms on the population pharmacokinetics of clobazam and N-desmethylclobazam in japanese patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Body Weight; Child; Child, Preschool; Clobazam; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Epilepsy; Female; Gene Frequency; Humans; Infant; Japan; Male; Metabolic Clearance Rate; Middle Aged; NADPH-Ferrihemoprotein Reductase; Polymorphism, Genetic; Retrospective Studies; Sex Factors | 2014 |
Clobazam and its active metabolite N-desmethylclobazam display significantly greater affinities for α₂- versus α₁-GABA(A)-receptor complexes.
Topics: Allosteric Site; Animals; Anticonvulsants; Benzodiazepines; Binding Sites; Brain; Clobazam; Clonazepam; HEK293 Cells; Humans; Kinetics; Male; Mice; Mutation; Protein Binding; Pyridines; Rats; Receptors, GABA-A; Seizures; Zolpidem | 2014 |
A physiologically based pharmacokinetic model for clobazam and stiripentol in adults and children.
Topics: Adult; Anticonvulsants; Benzodiazepines; Child; Clobazam; Computer Simulation; Dioxolanes; Drug Interactions; Drug Therapy, Combination; Humans; Metabolic Clearance Rate; Models, Biological; Tissue Distribution | 2015 |
Fatal anoxia due to rachacha consumption: Two cases reported.
Topics: Adult; Alcohol Drinking; Benzodiazepines; Clobazam; Codeine; Female; Flowering Tops; Forensic Toxicology; Humans; Hypoxia; Male; Morphine; Papaver | 2014 |
Pharmacokinetics of clobazam and N-desmethylclobazam in children with dravet syndrome receiving concomitant stiripentol and valproic Acid.
Topics: Anticonvulsants; Benzodiazepines; Body Weight; Child; Child, Preschool; Clobazam; Dioxolanes; Drug Interactions; Drug Therapy, Combination; Epilepsies, Myoclonic; Female; Humans; Male; Prospective Studies; Randomized Controlled Trials as Topic; Valproic Acid | 2015 |
Functional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABA(A) receptors expressed in Xenopus laevis oocytes.
Topics: Animals; Benzodiazepines; Clobazam; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Gene Expression; Humans; Oocytes; Receptors, GABA-A; Xenopus laevis | 2015 |
Drug-drug interaction between clobazam and cannabidiol in children with refractory epilepsy.
Topics: Adolescent; Benzodiazepines; Cannabidiol; Child; Child, Preschool; Clobazam; Cytochrome P-450 Enzyme System; Drug Interactions; Epilepsy; Female; Humans; Male; Young Adult | 2015 |
Therapeutic Drug Monitoring of Clobazam and Its Metabolite-Impact of Age and Comedication on Pharmacokinetic Variability.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Male; Middle Aged; Norway; Pharmacogenetics; Retrospective Studies; Young Adult | 2016 |
The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia.
Topics: Analgesics, Non-Narcotic; Animals; Benzodiazepines; Clobazam; Dose-Response Relationship, Drug; Female; HEK293 Cells; Humans; Hyperalgesia; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Protein Binding; Receptors, GABA-A | 2016 |
Correlating blood and urinary concentrations of clobazam doses in Japanese children and adolescents with intractable epilepsy.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Asian People; Benzodiazepines; Child; Child, Preschool; Clobazam; Drug Resistant Epilepsy; Female; Humans; Male; Young Adult | 2017 |
Interactions between cannabidiol and commonly used antiepileptic drugs.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Benzodiazepines; Cannabidiol; Child; Child, Preschool; Clobazam; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Fructose; Humans; Male; Middle Aged; Topiramate; Triazoles; Young Adult | 2017 |
Impact of Drug Interactions on Clobazam and N-Desmethylclobazam Concentrations in Pediatric Patients With Epilepsy.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Cytochrome P-450 CYP2C19 Inhibitors; Cytochrome P-450 CYP3A Inducers; Drug Interactions; Epilepsy; Female; Humans; Infant; Male; Retrospective Studies; Young Adult | 2018 |
Protein precipitation method for determination of clobazam and N-desmethylclobazam in human plasma by LC-MS/MS.
Topics: Benzodiazepines; Chemical Precipitation; Chromatography, Liquid; Clobazam; Drug Stability; Hemolysis; Humans; Hyperlipidemias; Linear Models; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2020 |
Pharmacokinetic Variability During Long-Term Therapeutic Drug Monitoring of Valproate, Clobazam, and Levetiracetam in Patients With Dravet Syndrome.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Dioxolanes; Drug Monitoring; Epilepsies, Myoclonic; Epilepsy; Female; Humans; Levetiracetam; Male; Middle Aged; Norway; Retrospective Studies; Valproic Acid; Young Adult | 2020 |