n-depropylpropafenone has been researched along with 5-hydroxypropafenone in 18 studies
| Studies (n-depropylpropafenone) | Trials (n-depropylpropafenone) | Recent Studies (post-2010) (n-depropylpropafenone) | Studies (5-hydroxypropafenone) | Trials (5-hydroxypropafenone) | Recent Studies (post-2010) (5-hydroxypropafenone) |
|---|---|---|---|---|---|
| 20 | 2 | 2 | 59 | 3 | 3 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (38.89) | 18.7374 |
| 1990's | 7 (38.89) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD | 1 |
| Tang, YN; Zhang, WL | 1 |
| Follath, F; Ha, HR; Oti-Amoako, K; Vozeh, S | 1 |
| Leloux, MS; Maes, RA | 1 |
| Follath, F; Ha, HR; Haefeli, W; Vlcek, J; Vozeh, S | 1 |
| Adamantidis, MM; Broly, F; Caron, JF; Dupuis, BA; Honore, E; Libersa, CC; Rouet, R; Wajman, A | 1 |
| Erstad, BL; Furman, C; Hoyer, GL; Kirsten, EB; Marcus, FI; Nolan, PE | 1 |
| Brewington, J; Kirsten, EB; Zoble, RG | 1 |
| Iansmith, DH; Roden, DM; Siddoway, LA; Thompson, KA; Woosley, RL | 1 |
| Benfenati, E; Chen, ZM; Gavinelli, M; Latini, R; Marchi, S; Sica, A | 1 |
| Danilo, P; Forster, M; Malfatto, G; Rosen, MR; Sodowick, B; Zaza, A | 1 |
| Kates, RE; Winkle, RA; Yee, YG | 1 |
| Liu, L; Tang, YN; Wang, ZY; Zhang, WL | 1 |
| Giesbrecht, E; Ito, S; Koren, G; Verjee, Z; Woodland, C | 1 |
| Belpaire, F; Buylaert, W; Calle, P; Fonck, K; Haenebalcke, C; Hemeryck, A; Jordaens, L | 1 |
| Cahill, SA; Gross, GJ | 1 |
| Afshar, M; Thormann, W | 1 |
| Bhatt, C; Desai, N; Ghoghari, A; Jha, A; Patel, H; Shah, S; Srinivas, NR | 1 |
2 trial(s) available for n-depropylpropafenone and 5-hydroxypropafenone
| Article | Year |
|---|---|
Pharmacokinetic and pharmacodynamic evaluation of propafenone in patients with ventricular arrhythmia. Propafenone Research Group.
Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation; Electrocardiography; Female; Heart Rate; Heart Ventricles; Humans; Male; Middle Aged; Propafenone; Random Allocation | 1989 |
A sensitive quantitative assay for the determination of propafenone and two metabolites, 5-hydroxypropafenone and N-depropylpropafenone, in human K2EDTA plasma using LC-MS/MS with ESI operated in positive mode.
Topics: Administration, Oral; Chromatography, Liquid; Drug Stability; Edetic Acid; Humans; Limit of Detection; Linear Models; Propafenone; Reproducibility of Results; Tandem Mass Spectrometry | 2017 |
16 other study(ies) available for n-depropylpropafenone and 5-hydroxypropafenone
| Article | Year |
|---|---|
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents.
Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2004 |
[Simultaneous determination of propafenone and its active metabolite in serum by high performance liquid chromatography].
Topics: Anti-Arrhythmia Agents; Humans; Propafenone | 1992 |
The relative potency of major metabolites and enantiomers of propafenone in an experimental reperfusion arrhythmia model.
Topics: Animals; Arrhythmias, Cardiac; Biotransformation; Chromatography, High Pressure Liquid; Male; Myocardial Reperfusion Injury; Propafenone; Rats; Rats, Inbred Strains; Stereoisomerism | 1990 |
Identification and determination of propafenone and its principal metabolites in human urine using capillary gas chromatography/mass spectrometry.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Propafenone | 1991 |
Nonlinear kinetics of propafenone metabolites in healthy man.
Topics: Biotransformation; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Injections, Intravenous; Male; Propafenone | 1990 |
Comparative electrophysiological effects of propafenone, 5-hydroxy-propafenone, and N-depropylpropafenone on guinea pig ventricular muscle fibers.
Topics: Action Potentials; Animals; Female; Guinea Pigs; Heart; In Vitro Techniques; Male; Membrane Potentials; Papillary Muscles; Propafenone | 1989 |
Effects of coadministration of propafenone on the pharmacokinetics of digoxin in healthy volunteer subjects.
Topics: Adult; Digoxin; Drug Interactions; Half-Life; Humans; Male; Propafenone | 1989 |
Potent electrophysiologic effects of the major metabolites of propafenone in canine Purkinje fibers.
Topics: Action Potentials; Animals; Biotransformation; Dogs; Heart Conduction System; In Vitro Techniques; Propafenone; Purkinje Fibers | 1988 |
High-performance liquid chromatographic separation and mass spectrometric identification of propafenone, 5-hydroxypropafenone and N-depropylpropafenone.
Topics: Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Propafenone | 1988 |
Electrophysiologic, inotropic and antiarrhythmic effects of propafenone, 5-hydroxypropafenone and N-depropylpropafenone.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Electrophysiology; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Myocardial Contraction; Papillary Muscles; Propafenone; Purkinje Fibers; Tachycardia | 1988 |
Metabolite cumulation during chronic propafenone dosing in arrhythmia.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Female; Humans; Male; Middle Aged; Propafenone; Propiophenones; Time Factors | 1985 |
[Metabolism of propafenone and lidocaine in combination in rat liver supernatant].
Topics: Animals; Drug Synergism; Lidocaine; Liver; Male; Propafenone; Rats; Rats, Wistar | 1994 |
The digoxin-propafenone interaction: characterization of a mechanism using renal tubular cell monolayers.
Topics: Animals; Anti-Arrhythmia Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Digoxin; Dogs; Drug Interactions; Female; Kidney Tubules; Propafenone; Vinblastine | 1997 |
ECG changes and plasma concentrations of propafenone and its metabolites in a case of severe poisoning.
Topics: Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Electrocardiography; Female; Half-Life; Heart; Humans; Middle Aged; Poisoning; Propafenone | 1998 |
Propafenone and its metabolites preferentially inhibit IKr in rabbit ventricular myocytes.
Topics: Animals; Anti-Arrhythmia Agents; Heart Ventricles; Male; Myocardium; Myocytes, Cardiac; Potassium Channels; Propafenone; Rabbits | 2004 |
Validated capillary electrophoresis assay for the simultaneous enantioselective determination of propafenone and its major metabolites in biological samples.
Topics: Anti-Arrhythmia Agents; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Electrophoresis, Capillary; Humans; Microsomes, Liver; Propafenone; Reproducibility of Results; Stereoisomerism | 2006 |