n-demethyltramadol has been researched along with o-demethyltramadol in 25 studies
| Studies (n-demethyltramadol) | Trials (n-demethyltramadol) | Recent Studies (post-2010) (n-demethyltramadol) | Studies (o-demethyltramadol) | Trials (o-demethyltramadol) | Recent Studies (post-2010) (o-demethyltramadol) |
|---|---|---|---|---|---|
| 26 | 5 | 18 | 150 | 34 | 73 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.00) | 18.2507 |
| 2000's | 6 (24.00) | 29.6817 |
| 2010's | 15 (60.00) | 24.3611 |
| 2020's | 3 (12.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blaschke, G; Elsing, B | 1 |
| Allegaert, K; Cossey, V; de Hoon, J; Debeer, A; Devlieger, H; Tibboel, D; Van den Anker, JN; Verbesselt, R | 1 |
| Azanza, JR; Campanero, MA; Cardenas, E; García Quetglas, E; Sádaba, B | 1 |
| Allegaert, K; de Hoon, J; Debeer, A; Rayyan, M; Verbesselt, R | 1 |
| Ardakani, YH; Rouini, MR | 1 |
| Ardakani, YH; Foroumadi, A; Mehvar, R; Rouini, MR | 1 |
| Giorgi, M; Kowalski, C; Lebkowska-Wieruszewska, B; Saccomanni, G | 1 |
| Charlier, C; De Backer, B; Denooz, R; Renardy, F | 1 |
| Carvalho, TM; De Moraes, NV; Godoy, AL; Lanchote, VL; Marques, MP; Martinez, EZ | 1 |
| Boothe, DM; Cruz-Espindola, C; Mitchum, EJ; Springfield, J; Stewart, AJ | 1 |
| Buono, C; Ly, BT; Stone, JA; Thornton, SL; Wu, AH | 1 |
| de Moraes, NV; Godoy, AL; Lanchote, VL; Lauretti, GR; Napolitano, MN; Santos, NR | 1 |
| Coller, JK; Colvill, J; Farquharson, AL; James, HM; Michalakas, JR; Somogyi, AA; White, JM | 1 |
| Baumgartner, MR; Guglielmello, R; Kraemer, T; Madry, MM; Rust, KY | 1 |
| Button, J; El-Sayed, AA; Holt, DW; Mohamed, KM; Nasser, AY | 1 |
| Barbera, N; Bosco, A; Fisichella, M; Indorato, F; Romano, G; Spadaro, G | 1 |
| Cagnardi, P; Ferraresi, C; Pecile, A; Ravasio, G; Villa, R; Zani, DD; Zonca, A | 1 |
| Carlsson, B; Haage, P; Josefsson, M; Kronstrand, R; Kugelberg, FC | 1 |
| Knych, HK; McKemie, DS; Steffey, EP; White, AM | 1 |
| Jang, JH; Jang, WJ; Jeong, CH; Lee, S; Park, B; Seo, YH; Yu, H | 1 |
| Hiraide, T; Kawakami, J; Naito, T; Sato, H; Tanaka, H; Yamada, Y | 1 |
| Court, MH; Greene, SA; Grubb, TL; Joo, H; Kukanich, B; Mealey, KL; Perez Jimenez, TE | 1 |
| Itoh, K; Kawakami, J; Naito, T; Suzuki, K; Tanaka, H; Yamada, Y | 1 |
| Dang, LTVL; Haage, P; Johansen, SS; Kronstrand, R; Kugelberg, FC; Nielsen, MKK | 1 |
| Govendir, M; Kimble, B; Valtchev, P; Vogelnest, L | 1 |
1 review(s) available for n-demethyltramadol and o-demethyltramadol
| Article | Year |
|---|---|
Quantification in postmortem blood and identification in urine of tramadol and its two main metabolites in two cases of lethal tramadol intoxication.
Topics: Adolescent; Aged; Analgesics, Opioid; Drug Overdose; Fatal Outcome; Female; Forensic Toxicology; Humans; Substance Abuse Detection; Tramadol | 2010 |
5 trial(s) available for n-demethyltramadol and o-demethyltramadol
| Article | Year |
|---|---|
Stereoselective pharmacokinetic analysis of tramadol and its main phase I metabolites in healthy subjects after intravenous and oral administration of racemic tramadol.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Female; Humans; Infusions, Intravenous; Male; Models, Biological; Stereoisomerism; Tramadol | 2007 |
Pharmacokinetics of tramadol and its three main metabolites in healthy male and female volunteers.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Area Under Curve; Female; Half-Life; Humans; Iran; Male; Phenotype; Polymorphism, Genetic; Sex Factors; Tramadol | 2007 |
Inhibition of CYP2D6-mediated tramadol O-demethylation in methadone but not buprenorphine maintenance patients.
Topics: Administration, Oral; Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Drug Interactions; Female; Humans; Male; Methadone; Middle Aged; Opiate Substitution Treatment; Tramadol; Young Adult | 2012 |
Effects of age on the pharmacokinetics of tramadol and its active metabolite, O-desmethyltramadol following intravenous administration to foals.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Area Under Curve; Female; Half-Life; Horse Diseases; Horses; Male; Tramadol | 2016 |
Oral Coadministration of Fluconazole with Tramadol Markedly Increases Plasma and Urine Concentrations of Tramadol and the
Topics: Administration, Oral; Analgesics, Opioid; Animals; Cross-Over Studies; Dogs; Drug Interactions; Female; Fluconazole; Male; Pain; Random Allocation; Tramadol | 2019 |
19 other study(ies) available for n-demethyltramadol and o-demethyltramadol
| Article | Year |
|---|---|
Achiral and chiral high-performance liquid chromatographic determination of tramadol and its major metabolites in urine after oral administration of racemic tramadol.
Topics: Administration, Oral; Chromatography, High Pressure Liquid; Humans; Stereoisomerism; Tramadol | 1993 |
Maturational changes in the in vivo activity of CYP3A4 in the first months of life.
Topics: Age Factors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Infant, Newborn; Linear Models; Tramadol | 2006 |
Urinary metabolites to assess in vivo ontogeny of hepatic drug metabolism in early neonatal life.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dealkylation; Feasibility Studies; Glucuronosyltransferase; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Isoenzymes; Liver; Reproducibility of Results; Substrate Specificity; Tramadol | 2007 |
Enantioselective determination of tramadol and its main phase I metabolites in human plasma by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Humans; Kinetics; Orosomucoid; Quality Control; Sensitivity and Specificity; Stereoisomerism; Tramadol | 2008 |
Pharmacokinetic evaluation of tramadol and its major metabolites after single oral sustained tablet administration in the dog: a pilot study.
Topics: Animals; Delayed-Action Preparations; Dogs; Male; Pilot Projects; Tramadol | 2009 |
Simultaneous analysis of tramadol, O-desmethyltramadol, and N-desmethyltramadol enantiomers in rat plasma by high-performance liquid chromatography-tandem mass spectrometry: application to pharmacokinetics.
Topics: Animals; Area Under Curve; Chromatography, High Pressure Liquid; Chromatography, Liquid; Male; Plasma; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism; Tandem Mass Spectrometry; Tramadol | 2011 |
Pharmacokinetics of tramadol and metabolites O-desmethyltramadol and N-desmethyltramadol in adult horses.
Topics: Analgesia; Analgesics, Opioid; Animals; Area Under Curve; Female; Half-Life; Horses; Male; Tramadol | 2011 |
False-positive urine phencyclidine immunoassay screen result caused by interference by tramadol and its metabolites.
Topics: Adult; Emergency Service, Hospital; False Positive Reactions; Female; Gas Chromatography-Mass Spectrometry; Humans; Immunoassay; Male; Phencyclidine; Phencyclidine Abuse; Tramadol | 2012 |
Enantioselective analysis of unbound tramadol, O-desmethyltramadol and N-desmethyltramadol in plasma by ultrafiltration and LC-MS/MS: application to clinical pharmacokinetics.
Topics: Adult; Analgesics, Opioid; Chromatography, Liquid; Female; Humans; Limit of Detection; Linear Models; Male; Middle Aged; Neuralgia; Reproducibility of Results; Stereoisomerism; Tandem Mass Spectrometry; Tramadol; Ultrafiltration | 2012 |
Metabolite to parent drug concentration ratios in hair for the differentiation of tramadol intake from external contamination and passive exposure.
Topics: Analgesics, Opioid; Chromatography, Liquid; Decontamination; Forensic Toxicology; Hair; Humans; Mass Spectrometry; Tramadol; Water; Workplace | 2012 |
Simultaneous determination of tramadol, O-desmethyltramadol and N-desmethyltramadol in human urine by gas chromatography-mass spectrometry.
Topics: Analgesics, Opioid; Gas Chromatography-Mass Spectrometry; Humans; Limit of Detection; Reference Standards; Reproducibility of Results; Tramadol | 2013 |
A suicidal poisoning due to tramadol. A metabolic approach to death investigation.
Topics: Analgesics, Opioid; Bile; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Gastrointestinal Contents; Humans; Middle Aged; Suicide; Tramadol | 2013 |
Clinical pharmacokinetics of tramadol and main metabolites in horses undergoing orchiectomy.
Topics: Analgesics, Opioid; Animals; Chromatography, High Pressure Liquid; Horses; Male; Orchiectomy; Pain Measurement; Tramadol | 2014 |
Quantitation of the enantiomers of tramadol and its three main metabolites in human whole blood using LC-MS/MS.
Topics: Administration, Oral; Analgesics, Opioid; Chromatography, Liquid; Forensic Toxicology; Healthy Volunteers; Humans; Limit of Detection; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism; Tandem Mass Spectrometry; Tramadol | 2016 |
Role of hair pigmentation in drug incorporation into hair.
Topics: Analgesics, Opioid; Animals; Cells, Cultured; Hair; Hair Color; Humans; Rats, Long-Evans; Tramadol | 2017 |
Impact of CYP genotype and inflammatory markers on the plasma concentrations of tramadol and its demethylated metabolites and drug tolerability in cancer patients.
Topics: Administration, Oral; Aged; Analgesics, Opioid; Asian People; C-Reactive Protein; Cancer Pain; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Female; Genotype; Humans; Interleukin-6; Male; Middle Aged; Neoplasms; Time Factors; Tramadol | 2018 |
A Reversed-Phase Mode LC-MS/MS Method Using a Polysaccharide Chiral Selector for Simultaneous Quantitation of Each Enantiomer of Tramadol and its Metabolites in Human Plasma and Evaluation of CYP-Mediated Stereoselective Demethylation.
Topics: Analgesics, Opioid; Cancer Pain; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Humans; Polysaccharides; Reproducibility of Results; Stereoisomerism; Tandem Mass Spectrometry; Tramadol | 2020 |
Temporal patterns of tramadol in hair after a single dose.
Topics: Adult; Analgesics, Opioid; Chromatography, Liquid; Female; Hair; Healthy Volunteers; Humans; Male; Mass Spectrometry; Time Factors; Tramadol; Young Adult | 2020 |
Pharmacokinetic profile of injectable tramadol in the koala (Phascolarctos cinereus) and prediction of its analgesic efficacy.
Topics: Analgesics, Opioid; Animals; Animals, Zoo; Australia; Chromatography, High Pressure Liquid; Female; Half-Life; Injections, Subcutaneous; Male; Mass Spectrometry; Phascolarctidae; Tramadol; Treatment Outcome; Wounds and Injuries | 2021 |