n-demethyltramadol has been researched along with methadone in 1 studies
| Studies (n-demethyltramadol) | Trials (n-demethyltramadol) | Recent Studies (post-2010) (n-demethyltramadol) | Studies (methadone) | Trials (methadone) | Recent Studies (post-2010) (methadone) |
|---|---|---|---|---|---|
| 26 | 5 | 18 | 13,630 | 1,463 | 3,957 |
| Protein | Taxonomy | n-demethyltramadol (IC50) | methadone (IC50) |
|---|---|---|---|
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 7.5 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.0041 | |
| Delta-type opioid receptor | Homo sapiens (human) | 1.09 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.512 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 9.7724 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coller, JK; Colvill, J; Farquharson, AL; James, HM; Michalakas, JR; Somogyi, AA; White, JM | 1 |
1 trial(s) available for n-demethyltramadol and methadone
| Article | Year |
|---|---|
Inhibition of CYP2D6-mediated tramadol O-demethylation in methadone but not buprenorphine maintenance patients.
Topics: Administration, Oral; Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Drug Interactions; Female; Humans; Male; Methadone; Middle Aged; Opiate Substitution Treatment; Tramadol; Young Adult | 2012 |