Page last updated: 2024-09-03

n-cyclopropyl adenosine-5'-carboxamide and 5'-n-methylcarboxamideadenosine

n-cyclopropyl adenosine-5'-carboxamide has been researched along with 5'-n-methylcarboxamideadenosine in 8 studies

Compound Research Comparison

Studies
(n-cyclopropyl adenosine-5'-carboxamide)
Trials
(n-cyclopropyl adenosine-5'-carboxamide)
Recent Studies (post-2010)
(n-cyclopropyl adenosine-5'-carboxamide)
Studies
(5'-n-methylcarboxamideadenosine)
Trials
(5'-n-methylcarboxamideadenosine)
Recent Studies (post-2010) (5'-n-methylcarboxamideadenosine)
140541016

Protein Interaction Comparison

ProteinTaxonomyn-cyclopropyl adenosine-5'-carboxamide (IC50)5'-n-methylcarboxamideadenosine (IC50)
Adenosine receptor A1Rattus norvegicus (Norway rat)0.105

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19902 (25.00)18.7374
1990's2 (25.00)18.2507
2000's2 (25.00)29.6817
2010's1 (12.50)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Daly, JW; Kusachi, S; Olsson, RA; Padgett, W; Thompson, RD; Ukena, D1
Bariana, DS; Brondyk, H; Egan, RS; Fung, A; Prasad, RN; Savic, M; Stein, HH; Tietje, K1
Fischer, B; Gallo-Rodriguez, C; Ji, XD; Melman, N; Olah, ME; Orlina, J; Pu, Q; Sanders, LH; Siegman, BD; van Galen, PJ1
de Zwart, M; IJzerman, AP; Kooijman, H; Kourounakis, A; Link, R; Spek, AL; von Frijtag Drabbe Künzel, JK1
Matsuda, A; Minakawa, N; Nakata, H; Saitoh, Y; Umino, T; Yoshioka, K1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Auchampach, JA; Bitant, A; Ciancetta, A; Cui, Z; Gao, ZG; Gavrilova, O; Jacobson, KA; Lieberman, DI; Liu, N; Mannes, P; Mattison, JA; Rao, H; Reitman, ML; Rothwell, AC; Salmaso, V; Tosh, DK; Vaughan, KL1
Banerjee, M; Blagg, BSJ; Brackett, CM; Gao, ZG; Jacobson, KA; Jung, YH; Tosh, DK1

Other Studies

8 other study(ies) available for n-cyclopropyl adenosine-5'-carboxamide and 5'-n-methylcarboxamideadenosine

ArticleYear
N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:9

    Topics: Adenosine; Adenylyl Cyclases; Adrenal Gland Neoplasms; Animals; Binding, Competitive; Biological Assay; Blood Platelets; Cell Membrane; Cerebral Cortex; Chemical Phenomena; Chemistry; Coronary Circulation; Dogs; Humans; Ligands; Pheochromocytoma; Rats; Receptors, Cell Surface; Receptors, Purinergic; Structure-Activity Relationship

1986
Modification of the 5' position of purine nucleosides. 2. Synthesis and some cardiovascular properties of adenosine-5'-(N-substituted)carboxamides.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:3

    Topics: Adenosine; Animals; Female; Hemodynamics; Lethal Dose 50; Male; Mice; Molecular Conformation; Structure-Activity Relationship

1980
Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists.
    Journal of medicinal chemistry, 1994, Mar-04, Volume: 37, Issue:5

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Brain; Cell Membrane; Cerebral Cortex; CHO Cells; Cricetinae; Molecular Structure; Rats; Receptors, Purinergic P1; Structure-Activity Relationship

1994
5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors.
    Journal of medicinal chemistry, 1999, Apr-22, Volume: 42, Issue:8

    Topics: Adenosine; Animals; Cell Line; Cerebral Cortex; CHO Cells; Corpus Striatum; Cricetinae; Crystallography, X-Ray; Cyclic AMP; Humans; In Vitro Techniques; Molecular Conformation; Purinergic P1 Receptor Agonists; Radioligand Assay; Rats; Receptors, Purinergic P1; Structure-Activity Relationship

1999
Nucleosides and nucleotides. 200. Reinvestigation of 5'-N-ethylcarboxamidoadenosine derivatives: structure-activity relationships for P(3) purinoceptor-like proteins.
    Journal of medicinal chemistry, 2001, Jan-18, Volume: 44, Issue:2

    Topics: Adenosine; Animals; Brain; In Vitro Techniques; Ligands; Magnetic Resonance Spectroscopy; Mass Spectrometry; Radioligand Assay; Rats; Receptors, Purinergic; Structure-Activity Relationship

2001
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Design and in Vivo Characterization of A
    Journal of medicinal chemistry, 2019, 02-14, Volume: 62, Issue:3

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Bridged Bicyclo Compounds; CHO Cells; Cricetulus; Drug Design; HEK293 Cells; Humans; Macaca fascicularis; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Molecular Structure; Receptor, Adenosine A1; Structure-Activity Relationship

2019
Biological Evaluation of 5'-(
    ACS medicinal chemistry letters, 2021, Mar-11, Volume: 12, Issue:3

    Topics:

2021