n-caffeoyltyramine and 3-tyrosine

N-Cinnamoyltyramine, N-caffeoyltyramine, N-feruloyltyramine, and N-sinapoyltyramine were synthesized and investigated to identify the most potent compound with anti-proliferation effect on HL-60, U937 and Jurkat cells. N-Caffeoyltyramine was the most potent with GI(50)=10 microM. The treatment of the cells with N-caffeoyltyramine activated caspase-3 activity, and inhibited the growth of cells via decreasing in protein tyrosine kinase activity including epidermal growth factor receptor. These data indicate that N-caffeoyltyramine is most potent compound, inducing cell death of the cancer cells by inhibiting protein tyrosine kinases and activating caspase-3 activity.

Topics: Antineoplastic Agents, Phytogenic; Caffeic Acids; Caspase 3; Caspases; Cell Division; DNA Fragmentation; Enzyme Activation; ErbB Receptors; HL-60 Cells; Humans; Jurkat Cells; Phosphorylation; Tyramine; Tyrosine; U937 Cells