Compounds > n-benzyladriamycin-14-valerate
Page last updated: 2024-09-03

n-benzyladriamycin-14-valerate and verapamil

n-benzyladriamycin-14-valerate has been researched along with verapamil in 3 studies

Compound Research Comparison

Studies
(n-benzyladriamycin-14-valerate)		Trials
(n-benzyladriamycin-14-valerate)		Recent Studies (post-2010)
(n-benzyladriamycin-14-valerate)		Studies
(verapamil)		Trials
(verapamil)		Recent Studies (post-2010) (verapamil)
250317,6211,5272,067

Protein Interaction Comparison

ProteinTaxonomyn-benzyladriamycin-14-valerate (IC50)verapamil (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)6.8
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.297
ATP-dependent translocase ABCB1Mus musculus (house mouse)2
ATP-dependent translocase ABCB1Homo sapiens (human)2.2346
Cytochrome P450 3A4Homo sapiens (human)3.8008
Alpha-2A adrenergic receptorHomo sapiens (human)0.579
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)3.02
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
Catechol O-methyltransferaseHomo sapiens (human)0.2
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)8
Histamine H2 receptorHomo sapiens (human)2.59
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.442
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.297
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)3.02
Sodium-dependent serotonin transporterHomo sapiens (human)0.24
Multidrug resistance-associated protein 1 Homo sapiens (human)5.598
D(3) dopamine receptorHomo sapiens (human)0.186
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.165
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)6.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.2
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.3945
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.2
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.175
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.1934

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dockter, ME; Israel, M; Lothstein, L; Sweatman, TW1
Koseki, Y; Lothstein, L; Sweatman, TW1
Baumgart, J; Harstrick, A; Scheulen, ME; Schleucher, N; Schroeder, J; Seeber, S; Vanhoefer, U; Wilke, H1

Other Studies

3 other study(ies) available for n-benzyladriamycin-14-valerate and verapamil

ArticleYear
Resistance to N-benzyladriamycin-14-valerate in mouse J774.2 cells: P-glycoprotein expression without reduced N-benzyladriamycin-14-valerate accumulation.
    Cancer research, 1992, Jun-15, Volume: 52, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Cells, Cultured; Doxorubicin; Drug Resistance; Flow Cytometry; Macrophages; Membrane Glycoproteins; Mice; Microscopy, Fluorescence; RNA, Messenger; Verapamil; Vinblastine

1992
P-glycoprotein overexpression in mouse cells does not correlate with resistance to N-benzyladriamycin-14-valerate (AD 198).
    Anti-cancer drugs, 1994, Volume: 5, Issue:6

    Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cells, Cultured; Dihydropyridines; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Immunoblotting; Mice; Tumor Cells, Cultured; Verapamil

1994
Activity of N-benzyl-adriamycin-14-valerate (AD198), a new anthracycline derivate, in multidrug resistant human ovarian and breast carcinoma cell lines.
    Anti-cancer drugs, 1995, Volume: 6, Issue:5

    Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carcinoma; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Female; Flow Cytometry; Humans; Ovarian Neoplasms; Tumor Cells, Cultured; Verapamil

1995