n-acetylsphingosine and sphingosine

n-acetylsphingosine has been researched along with sphingosine in 486 studies

Research

Studies (486)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's158 (32.51)18.2507
2000's259 (53.29)29.6817
2010's65 (13.37)24.3611
2020's4 (0.82)2.80

Authors

AuthorsStudies
Adachi, K; Hattori, T; Shizuri, Y1
Edinger, AL; Hanessian, S; Kim, SM; McCracken, AN; Nguyen, DG; O'Donoghue, H; Perryman, MS; Rafelski, S; Simitian, GS; Tessier, J; Viana, M; Wiher, T1
Deli, E; Kiss, Z2
Ghidoni, R; Kirschner, G; Leon, A; Miglio, A; Pitto, M1
Cline, HT; Constantine-Paton, M1
Benedict, M; Dixit, VM; Jäättelä, M; Shayman, JA; Tewari, M1
Ishikura, H; Okano, H; Okazaki, T; Okuma, M; Sawada, H; Sawai, H; Takeda, Y; Tashima, M; Umehara, H; Yamamoto, H1
Farach-Carson, MC; Karin, NJ; Liu, R1
Ridgway, ND1
Law, B; Rossie, S1
Hunchuk, N; Li, XB; Wong, K1
Jones, MJ; Murray, AW1
Allin, J; Ladenson, RC; Monsey, JD; Silbert, DF1
Lee, TC; Malone, B; Ou, MC; Shinozaki, K; Snyder, F1
Koretzky, GA; Latinis, KM1
Birrer, MJ; Bose, R; Fuks, Z; Grant, S; Haimovitz-Friedman, A; Jarvis, WD; Kolesnick, RN; Kyriakis, JM; Lin, XH; Szabo, E; Verheij, M; Yao, B; Zon, LI1
Broach, JR; Nickels, JT1
Welsh, N1
Dawson, G; Wiesner, DA1
Coso, OA; Cuvillier, O; Gutkind, S; Kleuser, B; Pirianov, G; Spiegel, S; Vanek, PG1
Abe, A; Radin, NS; Shayman, JA1
Chun, SY; Eisenhauer, K; Hsueh, AJ; Kaipia, A1
Handa, S; Kohsaka, H; Koike, R; Kushi, Y; Miyasaka, N; Mizushima, N; Yagita, H1
Chmura, SJ; Crane, MA; Hallahan, DE; Nodzenski, E; Quintans, J; Virudachalam, S; Weichselbaum, RR1
Hirokawa, M; Horiuchi, T; Kawabata, Y; Kitabayashi, A; Kuroki, J; Lee, M; Miura, AB1
Cavazzoni, M; Orlati, S; Rugolo, M1
Boxer, LA; Hinkovska-Galcheva, V; Mansfield, PJ; Shayman, JA; Suchard, SJ1
Beckett, MA; Chmura, SJ; Kufe, DW; Nodzenski, E; Quintans, J; Weichselbaum, RR1
Colell, A; Fernández-Checa, JC; García-Ruiz, C; Marí, M; Morales, A1
Bredesen, DE; Foster, LM; Kayalar, C; Keane, RW; Nonner, D; Ord, T; Reed, JC; Srinivasan, A; Testa, MP; Wang, HG1
Farooq, M; Larocca, JN; Norton, WT1
He, J; Oleinick, NL; Separovic, D1
Igarashi, Y; Nishiyama, K; Ohi, Y; Ozawa, M; Sakakura, C; Shirahama, T; Sweeney, EA; Takemoto, M1
Nakabo, Y; Pabst, MJ1
Hori, Y; Shinkai, M; Takeyama, Y; Ueda, T; Yamamoto, M1
Cagnoli, CM; Manev, H1
Beham, A; Herrmann, JL; McDonnell, TJ; Menter, DG; von Eschenbach, A1
Brossmer, R; Geilen, CC; Hannun, YA; Ihrig, P; Kolter, T; Orfanos, CE; Perry, D; Sadeghlar, F; Sandhoff, K; Wieder, T1
Chow, SC; Orrenius, S; Pörn-Ares, MI; Slotte, JP1
Johnson, GV; Xie, H1
Gudz, TI; Hoppel, CL; Tserng, KY1
Kaida, T; Kozawa, O; Suzuki, A; Tokuda, H; Uematsu, T1
Kikuchi, T; Kimura, T; Kobayashi, I; Kondo, Y; Kuwabara, A; Okajima, F; Sho, K; Tomura, H1
Gill, ZP; Holly, JM; Newcomb, PV; Perks, CM2
Fu, W; Furukawa, K; Goodman, Y; Luo, H; Mattson, MP1
Bielawska, AE; Hannun, YA; Jiang, L; Melkonyan, HS; Piot, C; Shapiro, JP; Tomei, LD; Umansky, SR; Wolfe, CL1
Berthier, F; Kushner, I; Lozanski, G1
Bergstrom, R; Jackson, J; Meisinger, J; Metz, RJ; Patel, S; Vellody, K; Wright, MA; Young, MR1
Baker, A; Briehl, MM; Payne, CM; Powis, G1
Cui, SH; Ito, M; Tanabe, F1
Cuvillier, O; Rosenthal, DS; Smulson, ME; Spiegel, S1
Cammarata, PR; Dunlap, JA; Lowe, WL; Thomas, MJ; Yorek, MA; Zhou, C1
Burl, S; Chahine, H; Damen, J; Eaves, A; Eaves, C; Krystal, G; Liu, L; Maguer-Satta, V1
Chatterjee, S; Diehl, AM; Lawler, JF; Roberts, E; Yin, M1
Elo, I; Eriksson, JE; Häkkinen, L; Holmström, TH; Kähäri, VM; Reunanen, N; Westermarck, J1
Kim, BC; Kim, JH1
Koezuka, Y; Motoki, K; Natori, T; Sakai, T; Uchimura, A; Ueno, H1
Gear, AR; Simon, CG1
Hanazawa, S; Ishida, M; Kitano, S; Ozaki, K; Takeda, H; Yasuda, H1
Borner, C; Jansen, B; Monney, L; Olivier, R; Otter, I; Poirier, GG1
Galvan, V; Roizman, B1
Dorrington, J; Foghi, A; Kuksis, A; Ravandi, A; Teerds, KJ; Van Der Donk, H1
Flores, I; Hannun, YA; Martinez-A, C; Mérida, I1
Hoekstra, D; Klappe, K; Kok, JW; Veldman, RJ1
Banno, Y; Ito, Y; Iwasaki-Bessho, Y; Kitajima, Y; Nozawa, Y; Yoshimura, S1
Harada-Shiba, M; Kamido, H; Kinoshita, M; Shimokado, K1
Kasahara, M; Kishida, E; Masuzawa, Y; Yano, M1
Hashizume, T; Kageura, T; Sato, T1
Ballou, LR; Kanekura, T; Kirtikara, K; Laulederkind, SJ; Raghow, R1
Chen, CW; Cheng, AL; Chuang, SE; Jee, SH; Kuo, ML1
Brachet, P; Canova, C; Chevalier, G; Remy, S; Wion, D1
Belloc, F; Bernard, P; Boisseau, MR; Chabrol, J; Dachary-Prigent, J; Dumain, P; Durrieu, F; Lacombe, F; Lacoste, L; Morjani, H; Reiffers, J1
Abe, K; Aoyagi, T; Eguchi, K; Ichinose, Y; Kawabe, Y; Koji, T; Migita, K; Nagataki, S; Nakamura, H; Tsukada, T1
Boland, MP; O'Neill, LA1
Birnbaum, MJ; Pittman, RN; Summers, SA; Zhou, H1
He, H; Hershberger, PA; McCarthy, SA1
Bilney, AJ; Hartfield, PJ; Murray, AW1
Card, GL; Pfau, JC; Walker, EB1
Jin, JS; Johns, DG; Webb, RC1
Bigl, V; Perez-Polo, JR; Rossner, S; Schliebs, R; Ueberham, U1
Berg, KA; Kaga, S; Ochi, A; Ragg, SJ1
Galadari, S; Hannun, YA; Kamibayashi, C; Kishikawa, K; Mumby, MC1
Bezombes, C; de Mas-Mansat, V; Jaffrézou, JP; Laurent, G; Levade, T; Maestre, N1
Birnbaum, MJ; Garza, LA; Summers, SA; Zhou, H1
Driscoll, TA; Hannun, YA; Obeid, LM; Zhang, J1
Patel, M1
Lakics, V; Vogel, SN1
Hama-Inaba, H; Matsushima, T; Mori, M; Muto, M; Ohyama, H; Saitoh, T; Takusagawa, M; Wang, B; Yamada, T1
Bártová, E; Bobková, M; Janáková, L; Rittich, B; Spanová, A1
Dorrington, JH; Foghi, A; Ghahremani, M1
Carabillò, M; Di Liberto, D; Giuliano, M; Lauricella, M; Tesoriere, G; Vento, R1
Inokuchi, J; Kuriyama, M; Mutoh, T; Tokuda, A1
Bitar, KN; Ibitayo, AI; Nozu, F; Owyang, C; Tsunoda, Y1
Csaba, G; Kovács, P; Müller, WE1
Andrieu-Abadie, N; Brossmer, R; Caspar-Bauguil, S; Escargueil-Blanc, I; Levade, T; Nègre-Salvayre, A; Salvayre, R1
Barnett, T; Birt, DF; Enkvetchakul, B; Geisler, V; Liotta, DC; Menaldino, DS; Merrill, AH; Pour, PM; Schwartzbauer, J1
Badwey, JA; Huang, R; Lian, JP; Robinson, D1
Kohsaka, H; Miyasaka, N; Mizushima, N1
Hirabayashi, Y; Inokuchi, J; Ito, M; Ji, L; Yamagata, T; Zhang, G1
Ammon, HP; Cartus, T; Drews, G; Heurich, RO1
Kurokawa, Y; Shimeno, H; Soeda, S; Tsunoda, T1
Barter, PJ; Bert, AG; Cockerill, P; Gamble, JR; Hii, CS; Khew-Goodall, Y; Rye, KA; Vadas, MA; Wang, L; Xia, P1
Bitar, KN; Wang, P1
Altura, BM; Altura, BT; Li, W; Zheng, T1
Duronio, V; Foltz, IN; Scheid, MP; Schrader, JW; Young, PR1
Carabillò, M; Emanuele, S; Giuliano, M; Lauricella, M; Tesoriere, G; Vento, R1
DeFranco, AL; MacKichan, ML1
Clift, RE; Reiners, JJ1
Hatch, GM; Kelly, SL; Xu, FY1
Désilets, M; Soboloff, J; Sorisky, A; Tsang, BK1
Centeno, F; Claro, E; Fuentes, JM; Mora, A; Soler, G1
Kikuchi, S; Moriwaka, F; Shinpo, K; Tashiro, K1
Blanco, JC; Medvedev, AE; Qureshi, N; Vogel, SN1
Downs, S; Ghosh, S; Hupke, M; Mahajan, S; Sudbeck, EA; Uckun, FM; Zheng, Y1
Barker, PA; MacPhee, I1
Blázquez, C; Daza, A; Galve-Roperh, I; Guzmán, M; Sánchez, C1
Csaba, G; Hegyesi, H; Köhidai, L; Kovács, P; Nemes, P1
Boustany, RM; Guo, WX; Nikbakht, K; Puranam, KL; Qian, WH1
Bitar, KN; Ibitayo, A; Su, X; Wang, P1
Couch, LH; Domon, O; Howard, PC; Jenkins, GR; McGarrity, LJ; Melchior, WB; Morris, SM; Muskhelishvili, L; Muskhelishvili, M; Tolleson, WH1
Alesse, E; Angelucci, A; Di Marcotullio, L; Giannini, G; Gulino, A; Zazzeroni, F1
Lee, BR; Um, HD1
Cifone, MG; Debatin, KM; Herr, I; Kurz, E; Martin-Villalba, A; Roncaioli, P; Schenkel, J1
Downward, J; Watton, SJ1
Bravery, CA; Hoffbrand, AV; Lewin, J; Mehta, AB; Mengubas, K; Owens, DL; Riordan, FA; Wickremasinghe, RG1
Kim, SS; Kim, YH1
Fahey, AA; Hoffbrand, AV; Lewin, J; Mehta, AB; Mengubas, K; Wickremasinghe, RG1
Asahara, H; Kira, J; Ohyagi, Y; Taniwaki, T; Yamada, T1
Koizumi, M; Masamune, A; Masamune, O; Mukaida, N; Shimosegawa, T; Toyota, T1
Aalame, N; Bodis, S; Glanzmann, C; Pruschy, M; Resch, H; Shi, YQ1
Akimoto, S; Fujino, MA; Hisano, N; Mitsumata, M; Ozaki, Y; Satoh, K; Yatomi, Y1
Campbell, WB; Li, PL; Zhang, DX; Zou, AP1
Dickens, M; Holly, JM; Newcomb, PV; Savage, PB; Stewart, CE; Tavare, J1
Czaja, MJ; Jones, BE; Lo, CR; Srinivasan, A; Valentino, KL1
Dallalio, G; Means, RT; North, M; Worden, BD1
Kozawa, O; Shinoda, J; Tokuda, H; Uematsu, T1
Bernard, P; Bobichon, H; Buisson-Legendre, N; Emonard, H; Haye, B; Hornebeck, W; Maquart, FX; Schneider, C1
Brindley, DN; Hanna, AN; Mei, J; Wang, CN; Xu, J1
Dobashi, K; Ghosh, B; Pahan, K; Singh, I1
Banno, Y; Hayashi, K; Nakashima, S; Nozawa, Y; Sakai, N; Sawada, M; Yamakawa, H; Yoshimura, S1
Korsmeyer, SJ; Krammer, PH; Peter, ME; Scaffidi, C; Schmitz, I; Zha, J1
Meng, YH; Mivechi, NF; Woessmann, W1
Gill, ZP; Holly, JM; Maile, LA; Perks, CM1
Belaud-Rotureau, MA; Belloc, F; Bernard, P; Durrieu, F; Lacombe, F; Lacoste, L; Vial, JP1
Askew, DJ; Brunner, T; Green, DR; Kuscuoglu, U; Miesfeld, RL1
Carlberg, C; Colston, KW; Danielsson, C; James, SY; Pirianov, G1
Cuvillier, O; Edsall, L; Kohama, T; Nava, V; Olivera, A; Poulton, S; Spiegel, S1
Han, JS; Jung, PM; Kim, JH; Park, BJ1
Abe, A; Shayman, JA1
Díaz-Laviada, I; Miguel, A; Ruiz, L1
Loh, TT; Sheng, HP; Zhang, QH1
Christensen, RA; de Aos Scherpenseel, I; Fujikawa, K; Jain, SK; Presman, E; Varticovski, L1
Ito, A; Nomura, Y; Okuma, Y; Tokumitsu, A; Uehara, T1
Handa, S; Ogura, M1
Blöchl, A; Heumann, R; Susen, K1
Bokoch, GM; Mooney, AF; Reed, JC; Sanders, LC; Schürmann, A; Sells, MA; Wang, HG1
Abend, M; Frombeck, S; Van Beuningen, D1
Bonnet, J; de Nanteuil, G; Léonce, S; Lesur, C; Pérez, V; Rolland, G; Sabatini, M; Thomas, M1
Cook, WJ; McDonald, JM; Micoli, KJ; Pan, G; Williams, JP; Wu, Y1
Allan, D1
Ginis, I; Hallenbeck, JM; Liu, J; Spatz, M1
Craighead, M; Pole, J; Waters, C1
Colburn, NH; Collins, K; Davis, MA; Flaws, JA; Young, M1
Brown, AM; Kristal, BS1
Alvarez, A; Cuadrado, A; López-Valdaliso, R; Martín, D; Salinas, M1
Mori, M; Tsushima, H1
Farndon, JR; Lai, T; Mihai, R; Schofield, G1
Aoyagi, T; Eguchi, K; Fukuda, T; Hirai, Y; Honda, S; Ida, H; Kawabe, Y; Kawakami, A; Kita, M; Migita, K; Tsukada, T; Yamasaki, S1
Cortés, ML; Galve-Roperh, I; Gómez del Pulgar, T; Guzmán, M; Izquierdo, M; Sánchez, C1
Lobner, D1
Domae, N; Kondo, T; Matsuda, T; Okazaki, T; Tashima, M; Uchiyama, T; Umehara, H; Yokoyama, K1
Baile, CA; Compton, MM; Dean, RG; Hartzell, DL; Hausman, DB; Hausman, GJ; Kim, HS; Martin, RJ1
Cho, S; Dawson, G1
Chan, C; Goldkorn, T1
Albar, JP; Brás, A; de Buitrago, GG; Leonardo, E; Martínez-A, C1
Ahmed, N; Berridge, MV1
Gendelman, HE; Kaul, M; Lipton, SA; Nottet, HS; Thylin, M; Yeh, MW; Zheng, J1
Clementi, E; De Nadai, C; Manfredi, AA; Paolucci, C; Rovere, P1
Abe, T; Tamai, M; Tomita, H1
Li, Y; Takao, N; Yamamoto, K1
Barsacchi, R; Cantoni, O; Clementi, E; De Nadai, C; Lièvremont, JP; Meldolesi, J; Moncada, S; Sciorati, C; Sestili, P1
Holly, JM; Meadows, KA; Stewart, CE1
Bektas, M; Daniel, P; Eberle, J; Geilen, CC; Orfanos, CE; Raisova, M; Wieder, T1
Colombaioni, L; Garcia-Gil, M; Tavarini, S1
Chik, CL; Ho, AK; Karpinski, E; Li, B; Negishi, T1
English, BK; Knapp, KM1
Enomoto, A; Hirano, K; Koyama, H; Matsumoto, Y; Morita, A; Sakai, K; Suzuki, N1
Azuma, T; Bierer, BE; Kwiatkowski, DJ; Martelli, MP; Posey, SC1
Campbell, V; Lynch, MA1
Alessio, M; Bonissoni, S; Brusco, A; Dianzani, I; Dianzani, U; Difranco, D; Franzese, A; Matrecano, E; Pignata, C; Ramenghi, U1
O'Byrne, D; Sansom, D1
Allan, D; Shawyer, A; Taylor, A1
Channing, DR; Nahorski, SR; Young, KW1
Fukunaga, T; Hatsuzawa, K; Nagahama, M; Tagaya, M; Tani, K; Yamamoto, A1
Hong, X; Hu, J; Jiang, Z; Long, H; Zhai, Z1
Benassi, L; Cossarizza, A; Di Nardo, A; Giannetti, A; Magnoni, C; Seidenari, S1
Dietrich, J; Geisler, C; Kastrup, J; Lauritsen, JP; Menné, C; Odum, N; Wegener, AM1
Agid, Y; Darios, F; Hirsch, EC; Lambeng, N; Michel, PP; Muriel, MP; Ruberg, M1
Pahlavani, MA; Vargas, DM1
Hirokawa, M; Kitabayashi, A; Kuroki, J; Miura, AB1
Geilen, CC; Müller-Wieprecht, V; Orfanos, CE; Riebeling, C; Stooss, A1
Béréziat, G; Klapisz, E; Koumanov, KS; Masliah, J; Wolf, C1
Colombini, M; Siskind, LJ1
Nagayama, Y; Namba, H; Ohtsuru, A; Sautin, Y; Shklyaev, S; Takamura, N; Yamashita, S1
Benito, M; Lorenzo, M; Navarro, P; Rohn, JL; Valverde, AM1
Campo, ML; Claro, E; Ramos, B; Salido, GM1
Li, XM; Meinkoth, J; Pittman, RN; Zhou, H1
Chai, MQ; Chen, HH; Chen, JS; Song, JG; Zhao, S1
Cheng, S; Mao, J; Rehder, V1
Kihara, T; Kimura, M; Ochiai, T; Oda, M; Ono, N; Shimeno, H; Soeda, S1
Hozumi, Y; Katagata, Y; Kondo, S; Maeshima, H; Mitsuhashi, Y; Sugiki, H1
Chen, Y; Ginis, I; Hallenbeck, JM1
Han, J; Shin, I1
Gerst, JE; Marash, M1
Koch, B; Loeffler, JP; Sée, V1
Lai, MT; Vlahos, CJ; Zinda, MJ1
Andersen, PS; Dietrich, J; Geisler, C; Kastrup, J; Lauritsen, JP; Menné, C; Odum, N; Wegener, AK1
Burrows, J; Connor, CE; Hearps, AC; Lowenthal, RM; Ragg, SJ; Woods, GM2
DeWald, DB; Stratford, S; Summers, SA1
Chang, YJ; Chen, CC; Chen, JJ; Sun, YT1
Cho, ES; Kim, DK; Lee, BR; Um, HD1
Hiraishi, H; Shimada, T; Terano, A1
Bielawska, A; Clavien, PA; Hannun, YA; Morse, MA; Rüdiger, HA; Selzner, M; Sindram, D1
Cuvillier, O; Edsall, LC; Milstien, S; Spiegel, S; Twitty, S1
Kajimoto, T; Ohmori, S; Saito, N; Sakai, N; Shirai, Y1
Fornace, AJ; Hollander, MC; Iglesias, M; Sheikh, MS; Woodworth, C; Yu, K; Zhan, Q1
Balendran, A; Batty, IH; Blair, AS; Downes, CP; Hajduch, E; Hundal, HS; Litherland, GJ1
Fabregat, I; Frago, LM; Pañeda, C; Varela-Nieto, I1
Axel, DI; Karsch, KR; Mayer, P; Shook, KS; Spyridopoulos, I; Viebahn, R1
Bode, AM; Castranova, V; Ding, M; Dong, Z; Huang, C; Li, J; Ma, WY; Shi, X; Vallyathan, V1
Chen, Y; Furuya, K; Ginis, I; Hallenbeck, JM; Takeda, H1
Cho, KH; Chung, JH; Kim, DS; Kim, KH; Kim, SY; Moon, SJ; Park, KC1
Chi, KH; Hsu, YW; Huang, WC; Lin, WW1
Li, PL; Zhang, DX; Zou, AP1
Bader, MF; Caumont, AS; Chasserot-Golaz, S; Du, G; Frohman, MA; Morris, AJ; Sciorra, VA; Vitale, N; Wu, S1
Bonnet, J; de Nanteuil, G; Deschamps, C; Lesur, C; Rolland, G; Sabatini, M; Thomas, M1
Belichenko, I; Morishima, N; Separovic, D1
Choi, MR; Suh, HW; Won, JS1
Di Virgilio, F; Ferrari, D; Pinton, P; Pozzan, T; Rapizzi, E; Rizzuto, R1
Beckett, MA; Gupta, N; Khodarev, NN; Khorasani, L; Kufe, DW; Nodzenski, E; Weichselbaum, RR; Yu, J1
Brugg, B; Caboche, J; Lemaigre-Dubreuil, Y; Mariani, J; Vanhoutte, P; Willaime, S1
Adzet, T; Alegret, M; Cabrero, A; Laguna, JC; Sánchez, R; Vázquez, M1
Hajnóczky, G; Pacher, P1
Abboud, HE; Ghosh Choudhury, G; Ghosh-Choudhury, N; Zhang, JH1
Gulbins, E; Roth, W; Wagenknecht, B; Weller, M; Wolburg, H1
Bourgoin, SG; Brindley, DN; Morris, AJ; Sciorra, VA; Singh, IN; Stromberg, LM1
Dillehay, DL; Kustin, EM; Lemonnier, LA; Merrill, AH; Roberts, PC; Schmelz, EM; Sullards, MC1
Inn-Oc, H; Joe, E; Jou, I; Yang, MS1
Cho, S; Dawson, G; Dawson, PE1
Bersacchi, R; Cantoni, O; Clementi, E; De Nadai, C; Guidarelli, A1
Begg, D; Berthiaume, LG; Bourgoin, S; Brindley, DN; Hanna, AN; Kikuchi, Y1
Budagian, V; Bulanova, E; Bulfone-Paus, S; Dürkop, H; Krause, H; Paus, R; Pohl, T1
Bourbon, NA; Kester, M; Sandirasegarane, L1
Cho, ES; Kim, DK; Seong, JK; Um, HD1
Elmendorf, JS; Kralik, SF; Leffler, BJ; Liu, P1
Fukuda, J; Kawano, Y; Miyakawa, I; Nakamura, S1
Deng, J; Hung, MC; Kloosterboer, F; Klostergaard, J; Levitt, ML; Liao, Y; Zhang, H1
Colombaioni, L; Frago, LM; Garcia-Gil, M; Pesi, R; Varela-Nieto, I1
Adzet, T; Alegret, M; Cabrero, A; Carrera, MV; Laguna, JC; Sanchez, RM1
Alonso, A; Goñi, FM; Montes, LR; Ruiz-Argüello, MB1
Abousalham, A; Brindley, DN; Dewald, J; Garbutt, M; Hobman, TC1
Bischoff, A; Czyborra, P; Fetscher, C; Herzig, S; Jakobs, KH; Meyer Zu Heringdorf, D; Michel, MC; Saxe, M1
Boxer, LA; Carey, SS; Hinkovska-Galcheva, V; Mansfield, PJ; Shayman, JA2
Ali-Osman, F; Fedi, P; Multani, AS; Pathak, S; Shou, J; Srivenugopal, KS1
Daido, N; Domae, N; Iwai, K; Kitano, T; Kondo, T; Okazaki, T; Suzuki, Y; Tashima, M; Uchiyama, T; Umehara, H; Watanabe, M1
Brindley, D; Degerman, E; Holm, C; Holst, LS; Landström, TR; Manganiello, V; Mei, J1
Aioi, A; Itakura, A; Matsuda, H; Tanaka, A; Tonogaito, H1
Alonso, JC; Centeno, F; Cuenda, A; Mora, A; Risco, AM; Sabio, G; Soler, G1
Brindley, DN; Hanna, AN; Xu, J1
Kim, HJ; Lee, KJ1
Calcerrada, MC; Catalán, RE; Martín, L; Martínez, AM; Miguel, BG1
Bitar, KN1
Ahn, EH; Schroeder, JJ2
Colombini, M; Kolesnick, RN; Siskind, LJ1
Gerst, JE; Gurunathan, S; Marash, M; Weinberger, A1
Domae, N; Iwai, K; Kitano, T; Kondo, T; Okazaki, T; Taguchi, Y; Uchiyama, T; Umehara, H; Watanabe, M; Yabu, T1
Chung, JH; Eun, HC; Kim, DS; Kim, KH; Kim, SY; Park, KC1
Chumley, MJ; Dobrowsky, RT; Hanson, JM; Sprott, KM1
Clarke, JB; Clemmons, DR; Holly, JM; McCaig, C; Perks, CM2
Boxer, LA; Hinkovska-Galcheva, V; Mansfield, PJ; Shayman, JA1
Bhadra, R; Mallick, S; Mandal, SK1
Faden, AI; Milstien, S; Movsesyan, V; Murthy, SK; Spiegel, S; Toman, RE1
Bono, A; Catalano, M; Ciaccio, M; Di Gaudio, F; Di Gesù, G; Di Liberto, D; Modica, G; Patti, M; Stassi, G; Todaro, M; Vetri, G; Zerilli, M1
De Ceballos, ML; Gómez Del Pulgar, T; Guzmán, M; Velasco, G1
Bono, F; Collen, D; Conway, EM; Devriese, A; Dol, F; Herbert, JM; Leducq, N; Luo, W; Lupu, F; Pollefeyt, S; Schaeffer, P; Steiner-Mosonyi, M1
Kögel, D; Münstermann, G; Poppe, M; Prehn, JH; Reimertz, C1
Buchholz, L; Clanachan, AS; Dyck, JR; Gandhi, M; Soltys, CL; Walsh, K1
Auffray, C; Brugg, B; Decraene, C; Eveno, E; Mariani, J; Matingou, C; Pietu, G; Ruberg, M; Tahi, F1
Bralet, MP; D'ortho, MP; Laperche, Y; Mavier, P; Preaux, AM1
Lee, TS; Lee, YP; Shin, CY; Sohn, UD; Song, HJ1
Baccino, FM; Bonelli, G; Codogno, P; De Stefanis, D; Ghidoni, R; Isidoro, C; Reffo, P; Sala, G1
Han, WS; Kim, DS; Kim, KH; Kim, SY; Park, KC; Yoo, JY; Youn, SW1
Hatakeyama, D; Kozawa, O; Matsuno, H; Oiso, Y; Tokuda, H; Uematsu, T1
Claro, E; El Mouedden, M; Jackowski, S; Ramos, B1
Allen, K; Griffiths, HR; Phillips, DC1
Aoki, J; Arai, H; Inoue, T; Johnston, JM; Marques, M; Pei, Y; Seltmann, H; Southall, MD; Travers, JB; Zouboulis, CC1
Wang, XQ; Xiao, AY; Yang, A; Yu, SP1
Dabaghyan, EA; Faden, AI; Movsesyan, VA; Stoica, BA; Yakovlev, AG1
Baird, G; Fogarty, KE; Pinton, P; Rapizzi, E; Rizzuto, R; Szabadkai, G; Tuft, RA; Vandecasteele, G; Wieckowski, MR1
Aggarwal, A; Kumar Mangalam, A; Naik, S1
Appierto, V; Basso, L; Cavadini, E; Chigorno, V; Formelli, F; Loberto, N; Prinetti, A; Prioni, S; Sonnino, S; Valsecchi, M; Villani, MG1
Aragonés, MD; Catalán, RE; Collado, MP; Fernández, I; Latorre, E1
Condrescu, M; Hantash, BM; Opuni, K; Reeves, JP1
Iwai, K; Kitano, T; Kondo, T; Okazaki, T; Taguchi, Y; Takahashi, A; Uchiyama, T; Umehara, H; Watanabe, M; Yabu, T1
Itoh, M; Iwai, K; Kitano, T; Kondo, T; Okazaki, T; Taguchi, Y; Tashima, M; Uchiyama, T; Watanabe, M; Yabu, T1
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Cho, YH; Kim, SG; Lee, CH1
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Cheng, EH; Korsmeyer, SJ; Oakes, SA; Opferman, JT; Pozzan, T; Scorrano, L; Sorcinelli, MD1
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Goodhew, KL; Holly, JM; Keith, AJ; Perks, CM; Savage, PB; Winters, ZE1
Hatano, M; Mizuno, M; Yoshida, J1
Jaiswal, AS; Narayan, S1
Eguchi, K; Hida, A; Huang, M; Ida, H; Izumi, Y; Kawakami, A; Miyashita, T; Nakamura, H; Nakashima, K; Origuchi, T; Tamai, M; Tanaka, F; Ueki, Y; Yamasaki, S1
Hakomori, S; Handa, K; Suzuki, E; Toledo, MS1
Fukuda, J; Kawano, Y; Matsumoto, H; Miyakawa, I; Narahara, H; Nasu, K1
Berdeaux, A; d'Anglemont de Tassigny, A; Ghaleh, B; Henry, P; Souktani, R1
Cao, LC; Cooney, R; Honeyman, TW; Jonassen, JA; Kennington, L; Scheid, CR1
Eisfelder, BJ; Greenberg, JT; Marvin, J; Yao, N1
Endoh, D; Hamasu, T; Hayashi, M; Kawana, A; Matsumoto, M; Okui, T1
Han, Y; Kim, CW; Kim, KS; Park, HW; Song, JY; Yi, SY; Yun, YS1
Aubert, N; Basille, M; Falluel-Morel, A; Fontaine, M; Fournier, A; Gonzalez, BJ; Vaudry, D; Vaudry, H1
Imaeda, N; Kondoh, N; Murase, T; Tsubota, T1
Aubert, N; Basille, M; Benard, M; Falluel-Morel, A; Fontaine, M; Fournier, A; Galas, L; Gonzalez, BJ; Vaudry, D; Vaudry, H1
Igarashi, Y; Okazaki, T; Taguchi, Y; Tomimoto, H; Yabu, T; Yamaoka, S1
Calderwood, SK; Jones, EL; Stevenson, MA; Zhao, MJ1
Altevogt, P; Condon, TP; Gast, D; Gutwein, P; Linderkamp, O; Marmé, A; Phong, MC; Riedle, S; Runz, S; Skorokhod, A; Stoeck, A1
Jenkins, GI; Knight, MR; Leaver, CJ; McDonald, K; Townley, HE1
Choi, JY; Choi, KD; Han, JY; Jeon, I; Kim, SH; Kim, SY; Kim, TY; Sihn, CR; Suh, EJ1
Alonso, A; Goñi, FM; Sot, J1
Dawson, G; Goswami, R; Kilkus, J; Phillips, G; Singh, D1
Arboleda, G; Gibson, RM; Waters, C1
Detre, C; Enyedi, A; Kiss, E; Kövesdi, D; Ludányi, K; Matkó, J; Panyi, G; Pászty, K; Rajnavölgyi, E; Varga, Z1
Alimov, AP; Giltiay, NV; Karakashian, AA; Ligthle, S; Nikolova-Karakashian, MN1
Boggaram, V; Chandru, H; Sparkman, L1
Kawano, Y; Narahara, H; Nasu, K; Nishida, M; Takai, N; Ueda, T1
Ahn, DS; Cho, YE; Jang, GJ; Lee, YH; Morgan, KG1
Bianchi, K; Carli, C; Rizzuto, R; Romagnoli, A; Szabadkai, G; Vandecasteele, G1
Calatayud, CA; Pasquini, JM; Pasquini, LA; Soto, EF1
Lecour, S; Opie, LH; Owira, P1
Gonos, ES; Kolettas, E; Kontargiris, E; Markopoulou, S; Skoufos, I; Tzavaras, T1
Bachmann, M; Barz, S; Kniep, B; Kniep, E; Malisan, F; Ozkucur, N; Rieber, EP; Testi, R1
Chen, H; Chen, S; Hsu, CY; Lee, JM; Xu, J; Zeng, C1
Abrahan, CE; German, OL; Miranda, GE; Rotstein, NP1
Deng, X; Xin, M1
Dong, CY; Li, BX; Ren, R; Zhang, XF1
Bartfai, T; Korn, H; Tabarean, IV1
Broussard, SR; Dantzer, R; Freund, GG; Johnson, RW; Kelley, KW; LeCleir, JM; McCusker, RH; Shen, WH; Strle, K1
Dedieu, S; El Btaouri, H; Martiny, L; Morjani, H; Rath, GM; Sartelet, H; Schneider, C1
Davidson, WS; Ghering, AB1
Aubert, N; de Jouffrey, S; Falluel-Morel, A; Fisch, C; Fournier, A; Gonzalez, BJ; Lebigot, JF; Rodriguez-Alvarez, J; Vaudry, D; Vaudry, H; Xifro, X1
Altevogt, P; Gast, D; Gutwein, P; Issa, Y; Sanderson, MP; Stoeck, A1
Hu, X; Lv, X; Shi, J; Wang, J1
Li, BX; Ren, R; Zhang, XF1
Ahmed, SF; Burdon, T; Farquharson, C; MacRae, VE1
JeBailey, L; Klip, A; Niu, W; Roessler, J; Rudich, A; Wanono, O1
Li, YL; Liu, JF; Lu, HT; Murata, NM; Yamakawa, T; Zhang, TH; Zhang, Y1
Baes, M; Denizot, Y; Van Overloop, H; Van Veldhoven, PP1
Allenberg, JR; Böckler, D; Klemm, K; Ryschich, E; Schmidt, J; Schumacher, H; Zhang, J1
Hu, XS; Lv, XW; Shi, JP; Wang, J1
Adachi, T; Kitajima, K; Sato, C1
Arboleda, G; Fernyhough, P; Gibson, RM; Huang, TJ; Verkhratsky, A; Waters, C1
Arboleda, G; Gibson, R; Waters, C1
Samadi, A1
de Castro e Paula, LA; Hansen, PJ1
Guo, RW; Qi, F; Shen, ZF; Shi, YK; Wang, XM; Yang, D; Yang, LX1
Caballero-Benítez, A; Lluch, M; Miñano, A; Morán, J; Rodríguez-Alvarez, J1
Aubert, N; Desfeux, A; Falluel-Morel, A; Fournier, A; Gonzalez, BJ; Laudenbach, V; Vaudry, H; Zhokhov, SS1
Kumar, P; Lee, YI; Lim, JY1
Bornancin, F; Graf, C; Rovina, P1
Chen, YC; Chien, CC; Liau, JS; Shen, SC; Wu, CY; Yang, LY1
Nicol, GD1
Georgopoulou, N; Hurel, C; Masgrau, R; Matsas, R; Papastefanaki, F; Thomaidou, D1
Li, B; Ren, R; Zhang, X; Zhang, Y1
Balboa, MA; Balsinde, J; Barceló-Torns, M; Barneda, D; Casas, J; Claro, E; Gubern, A; Masgrau, R; Picatoste, F1
Elner, SG; Elner, VM; Field, MG; Heckenlively, JR; Park, S; Petty, HR1
Chen, HW; Li, CC; Lii, CK; Liu, KL; Lu, CY; Tsai, CW1
Chen, SC; Chou, LC; Gean, PW; Huang, LJ; Kuo, SC; Lin, YC1
Du, YG; Lv, XW; Wang, J1
Fontés, G; Hagman, DK; Poitout, V; Rhodes, CJ; Rutter, J; Semache, M; Shah, R; Tremblay, C1
Hanck, T; Li, R; Reiser, G; Rohatgi, T1
Cho, JY; Lee, J; Lee, YG1
Furuchi, T; Homma, H; Katane, M; Sekine, M; Suzuki, T1
Abrahan, CE; Agnolazza, DL; Miranda, GE; Politi, LE; Rotstein, NP1
Kepp, O; Kroemer, G; Martins, I; Métivier, D; Michaud, M; Perfettini, JL; Schlemmer, F; Senovilla, L; Séror, C; Tesniere, A; Zitvogel, L1
Chao, SY; Chen, CY; Hsieh, RH; Jeng, JY; Lee, WH; Tsai, YH1
Callegari, MG; Campanella, M; Di Virgilio, F; Ferrari, D; Pinton, P; Pizzirani, C; Pozzan, T; Rimessi, A; Rizzuto, R1
Baumgarten, CM; Chalfant, CE; Raucci, FJ; Wijesinghe, DS1
Barillot, E; Criollo, A; Dessen, P; Galluzzi, L; Harel-Bellan, A; Hupé, P; Kepp, O; Kroemer, G; Lazar, V; Morselli, E; Paccard, C; Ripoche, H; Robert, T; Senovilla, L; Servant, N; Vitale, I1
Jun Yoo, S; Jun, EK; Kim, A; Kim, H; Kim, JH; Koh, GY; Moon, JH; Park, G; Soon Baik, C; Taek Lee, H; Yoon, BS; You, S1
Guo, MY; Moriyama, S; Nakao, S; Segawa, M; Sugiya, H1
Pozuelo-Rubio, M2
Chang, HW; Chen, BH; Chen, JY; Chen, WY; Chiu, CC; Chu, YC; Fang, K; Fu, TF; Huang, YL; Hwang, CC; Lee, JC; Lin, JC; Tsai, WH1
Arboleda, G; Arboleda, H; Cárdenas, Y; Matheus, L; Morales, LC; Rodríguez, Y1
Hedger, MP; Kazutaka, S; Muir, JA; Winnall, WR1
Kowluru, A1
Charpentier, E; El Btaouri, H; Greffe, Y; Martiny, L; Morjani, H1
Li, R; Reiser, G1
Kalo, D; Roth, Z1
Deng, Z; Du, WW; Fang, L; Jeyapalan, Z; Seth, A; Shan, SW; Yang, BB; Yang, BL; Yee, AJ; Zhang, Y1
Cho, D; Jung, MY; Kim, TS; Kue, CS1
Arboleda, G; Arboleda, H; Sánchez-Mora, RM1
Dou, Y; Lou, Y; Rimbach, G; Rong, W; Wu, J; Xia, B; Zhang, X1
Li, R; Reiser, G; Zhu, Z1
Furukawa, Y; Ishii, T; Karakida, S; Kawano, Y; Kira, N; Narahara, H1
Faden, AI; Hanscom, M; Piao, CS; Sabirzhanov, B; Stoica, BA1
Li, R; Wang, X; Zhang, XY1
Ford, AL; Gonzales, E; Holtzman, DM; Lee, JM; Lee, KY; West, T; Xiao, Q; Xu, J; Yan, P1
Asano, S; Hashimoto-Nishimura, M; Hayashi, A; Igarashi, Y; Kigawa, J; Kitatani, K; Kondo, T; Mitsutake, S; Okazaki, T; Takeya, H; Taniguchi, M; Umehara, H1
Chang, CC; Chen, WF; Lee, JJ; Lin, KH; Sheu, JR; Wang, SH1
Chae, GT; Jin, SH; Kim, SK; Lee, SB; Oh, E; Seo, G1
Birren, SJ; Enes, J; Luther, JA1
Adeli, K; Baker, C; Dekker, MJ; Naples, M; Qiu, W; Sacco, J; Samsoondar, J; Zhang, R1
Iwayama, H; Ueda, N1
Chiu, TT; Klip, A; Koshkina, A; Sun, Y1
Chen, SY; Cheng, CA; Hsu, CH; Hsu, YD; Lee, JT; Lin, CC; Lin, JC; Peng, GS1
Doyle, A; Leanza, L; O'Reilly, P; Szabo, I; Szegezdi, E; Venturini, E; Zoratti, M1
Chen, L; Geng, X; Guo, L; Li, H; Luo, C; Ma, L; Ou, X; Quan, S; Zeng, W1
Azevedo, F; Chaves, SR; Côrte-Real, M; Pacheco, A; Rego, A; Santos, J; Sousa, MJ1
Jia, W; Jiang, Q; Li, H; Qiu, Y; Sun, X; Xie, G; Zhao, A; Zheng, X; Zhong, W; Zhou, Y; Zhou, Z1
Bakhtiyari, S; Meshkani, R; Pasalar, P; Rajabibazl, M; Taheripak, G1
Bunte, RM; Chiu, GN; Chng, WJ; Ling, LU; Tan, KB1
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Wang, H; Wang, X; Zhou, Y; Zhu, W1
Chuang, JH; Hsieh, CT; Lin, Y; Yang, WC; Yin, Y1
Arboleda, G; Arboleda, H; Cookson, MR; Niño, A; Rojas-Charry, L1
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Canty, JM; Weil, BR1
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Li, R; Reiser, G; Stricker, R; Zhu, Z1
Ogiso, H; Okazaki, T; Taniguchi, M1
Arboleda, G; Arboleda, H; Jaramillo-Gómez, J; Niño, A1
Guo, Y; Huang, Y; Wang, L; Wu, S; Yang, M; Zhang, L; Zhang, Y; Zi, Y1
Banerjee, D; Dobierzewska, A; Giltiay, NV; Karakashian, AA; Nikolova-Karakashian, MN; Sathishkumar, S; Shi, L1
Feng, B; Li, X; Sun, L; Sun, W; Wang, Y1
An, D; Dong, M; Feng, M; Guan, Z; Jiang, S; Kuerban, K; Li, J; Peng, Y; Wang, Q; Ye, L1
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Ayub, M; Bae, JS; Jin, HK1

Reviews

2 review(s) available for n-acetylsphingosine and sphingosine

ArticleYear
A turn in the road: How studies on the pharmacology of glucosylceramide synthase inhibitors led to the identification of a lysosomal phospholipase A2 with ceramide transacylase activity.
    Glycoconjugate journal, 2004, Volume: 20, Issue:1

    Topics: Acylation; Acyltransferases; Animals; Cattle; Ceramides; DNA, Complementary; Enzyme Inhibitors; Glucosyltransferases; Humans; Lysosomes; Mice; Molecular Structure; Morpholines; Phospholipases A; Phospholipases A2; Signal Transduction; Sphingosine

2004
Novelty of Sphingolipids in the Central Nervous System Physiology and Disease: Focusing on the Sphingolipid Hypothesis of Neuroinflammation and Neurodegeneration.
    International journal of molecular sciences, 2021, Jul-08, Volume: 22, Issue:14

    Topics: Alzheimer Disease; Central Nervous System; Ceramides; Eicosanoids; Forecasting; Homeostasis; Humans; Inflammation; Lipoxygenase; Lysophospholipids; Membrane Lipids; Models, Biological; Nerve Degeneration; Neurodegenerative Diseases; Neuroglia; Neurons; Parkinson Disease; Phosphotransferases (Alcohol Group Acceptor); Prostaglandin-Endoperoxide Synthases; Sphingolipids; Sphingosine

2021

Other Studies

484 other study(ies) available for n-acetylsphingosine and sphingosine

ArticleYear
New ceramide from marine sponge Haliclona koremella and related compounds as antifouling substances against macroalgae.
    Journal of natural products, 1998, Jun-26, Volume: 61, Issue:6

    Topics: Animals; Ceramides; Eukaryota; Magnetic Resonance Spectroscopy; Mass Spectrometry; Porifera; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet

1998
Effects of stereochemistry, saturation, and hydrocarbon chain length on the ability of synthetic constrained azacyclic sphingolipids to trigger nutrient transporter down-regulation, vacuolation, and cell death.
    Bioorganic & medicinal chemistry, 2016, 09-15, Volume: 24, Issue:18

    Topics: Animals; Cell Death; Down-Regulation; Humans; Hydrocarbons; Membrane Transport Proteins; Sphingolipids; Stereoisomerism; Structure-Activity Relationship; Vacuoles

2016
Regulation of phospholipase D by sphingosine involves both protein kinase C-dependent and -independent mechanisms in NIH 3T3 fibroblasts.
    The Biochemical journal, 1992, Dec-15, Volume: 288 ( Pt 3)

    Topics: 3T3 Cells; Alkaloids; Animals; Bryostatins; Down-Regulation; Drug Interactions; Ethers, Cyclic; Hydrolysis; Lactones; Macrolides; Mice; Okadaic Acid; Phosphatidylethanolamines; Phospholipase D; Phospholipids; Platelet-Derived Growth Factor; Protein Kinase C; Sphingomyelin Phosphodiesterase; Sphingosine; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate

1992
Metabolism of semisynthetic single-chain GM1 derivatives in cerebellar granule cells in culture.
    Neurochemical research, 1991, Volume: 16, Issue:11

    Topics: Animals; Carbohydrate Sequence; Cells, Cultured; Cerebellum; G(M1) Ganglioside; Molecular Sequence Data; Rats; Sphingosine

1991
The differential influence of protein kinase inhibitors on retinal arbor morphology and eye-specific stripes in the frog retinotectal system.
    Neuron, 1990, Volume: 4, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Horseradish Peroxidase; Isoquinolines; Nerve Tissue Proteins; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Piperazines; Polyvinyls; Protein Kinase Inhibitors; Rana pipiens; Retina; Retinal Ganglion Cells; Sphingosine; Superior Colliculi; Visual Pathways

1990
Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells.
    Oncogene, 1995, Jun-15, Volume: 10, Issue:12

    Topics: Antigens, Surface; Apoptosis; Base Sequence; bcl-X Protein; Breast Neoplasms; Cell Division; Ceramides; Dexamethasone; Drug Resistance; Enzyme Activation; fas Receptor; Female; Humans; Luciferases; Molecular Sequence Data; NF-kappa B; Phospholipases A; Phospholipases A2; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Quinacrine; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1995
Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells.
    The Journal of biological chemistry, 1995, Nov-10, Volume: 270, Issue:45

    Topics: Apoptosis; Base Sequence; Curcumin; DNA, Neoplasm; Gene Expression; Genes, jun; Humans; Leukemia; Molecular Sequence Data; Oligonucleotides, Antisense; Proto-Oncogene Proteins c-jun; RNA, Messenger; Signal Transduction; Sphingosine; Transcription Factor AP-1; Tumor Cells, Cultured

1995
Effects of sphingosine derivatives on MC3T3-E1 pre-osteoblasts: psychosine elicits release of calcium from intracellualr stores.
    Biochemical and biophysical research communications, 1995, Sep-14, Volume: 214, Issue:2

    Topics: 3T3 Cells; Animals; Calcium; Fluorescent Dyes; Fura-2; Kinetics; Lysophospholipids; Mice; Osteoblasts; Phosphorylation; Phosphorylcholine; Psychosine; Sphingosine; Structure-Activity Relationship

1995
Inhibition of acyl-CoA:cholesterol acyltransferase in Chinese hamster ovary (CHO) cells by short-chain ceramide and dihydroceramide.
    Biochimica et biophysica acta, 1995, Apr-28, Volume: 1256, Issue:1

    Topics: Animals; Ceramides; CHO Cells; Cholesterol; Cricetinae; Esterification; Hydroxycholesterols; Kinetics; Lipoproteins, LDL; Sphingosine; Sterol O-Acyltransferase

1995
The dimeric and catalytic subunit forms of protein phosphatase 2A from rat brain are stimulated by C2-ceramide.
    The Journal of biological chemistry, 1995, May-26, Volume: 270, Issue:21

    Topics: Animals; Antibody Specificity; Binding Sites; Brain; Catalysis; Dose-Response Relationship, Drug; Enzyme Activation; Isoenzymes; Male; Phosphoprotein Phosphatases; Protein Conformation; Protein Phosphatase 2; Rats; Second Messenger Systems; Sphingosine

1995
Preferential inhibition of phorbol ester-induced hydrolysis of phosphatidylethanolamine by N-acetylsphingosine in NIH 3T3 fibroblasts.
    FEBS letters, 1995, May-29, Volume: 365, Issue:2-3

    Topics: 3T3 Cells; Animals; Carbon Radioisotopes; Fibroblasts; Hydrolysis; Indoles; Kinetics; Maleimides; Mice; Palmitic Acid; Palmitic Acids; Phosphatidylethanolamines; Phospholipase D; Protein Kinase C; Radioisotope Dilution Technique; Rats; Sphingosine; Tetradecanoylphorbol Acetate

1995
N-acetylsphingosine (C2-ceramide) inhibited neutrophil superoxide formation and calcium influx.
    The Journal of biological chemistry, 1995, Feb-17, Volume: 270, Issue:7

    Topics: Alkaloids; Biological Transport, Active; Blood Proteins; Calcium; Enzyme Activation; Humans; In Vitro Techniques; Kinetics; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Spectrometry, Fluorescence; Sphingosine; Staurosporine; Superoxides

1995
Evidence that ceramide selectively inhibits protein kinase C-alpha translocation and modulates bradykinin activation of phospholipase D.
    The Journal of biological chemistry, 1995, Mar-10, Volume: 270, Issue:10

    Topics: Animals; Blotting, Western; Bradykinin; Cell Line; Ceramides; Enzyme Activation; Epidermis; Fibroblasts; Humans; Inositol Phosphates; Isoenzymes; Kinetics; Mice; Phospholipase D; Protein Kinase C; Skin; Sphingomyelin Phosphodiesterase; Sphingosine; Time Factors

1995
Utilization of exogenously supplied sphingosine analogues for sphingolipid biosynthesis in Chinese hamster ovary and mouse LM cell fibroblasts.
    The Journal of biological chemistry, 1993, Apr-15, Volume: 268, Issue:11

    Topics: Acetates; Acetic Acid; Animals; Carbon Radioisotopes; Cell Division; CHO Cells; Choline; Cricetinae; Kinetics; L Cells; Mice; Palmitic Acid; Palmitic Acids; Phospholipids; Radioisotope Dilution Technique; Serine; Sphingolipids; Sphingomyelins; Sphingosine; Tritium

1993
Biosynthesis of N-acetylsphingosine by platelet-activating factor: sphingosine CoA-independent transacetylase in HL-60 cels.
    The Journal of biological chemistry, 1996, Jan-05, Volume: 271, Issue:1

    Topics: Acetyltransferases; Binding, Competitive; Chromatography, Thin Layer; Diethyl Pyrocarbonate; Enzyme Inhibitors; Ethylmaleimide; HL-60 Cells; Humans; Lung; Platelet Activating Factor; Sphingosine; Stereoisomerism; Substrate Specificity

1996
Fas ligation induces apoptosis and Jun kinase activation independently of CD45 and Lck in human T cells.
    Blood, 1996, Feb-01, Volume: 87, Issue:3

    Topics: Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; fas Receptor; Humans; JNK Mitogen-Activated Protein Kinases; Leukemia-Lymphoma, Adult T-Cell; Leukocyte Common Antigens; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-jun; Signal Transduction; Sorbitol; Sphingosine; src-Family Kinases; T-Lymphocytes; Tumor Cells, Cultured

1996
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.
    Nature, 1996, Mar-07, Volume: 380, Issue:6569

    Topics: Animals; Apoptosis; Cattle; Cell Line; Ceramides; Enzyme Activation; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutation; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-jun; Signal Transduction; Sphingosine; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1996
A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae.
    Genes & development, 1996, Feb-15, Volume: 10, Issue:4

    Topics: Apoptosis; Cell Cycle; Cell Division; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Flow Cytometry; Fungal Proteins; G1 Phase; Genes, Fungal; Membrane Proteins; Mutation; Phosphoprotein Phosphatases; Saccharomyces cerevisiae; Signal Transduction; Sphingosine

1996
Interleukin-1 beta-induced ceramide and diacylglycerol generation may lead to activation of the c-Jun NH2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5F.
    The Journal of biological chemistry, 1996, Apr-05, Volume: 271, Issue:14

    Topics: Activating Transcription Factor 2; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Ceramides; Cyclic AMP Response Element-Binding Protein; Diglycerides; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Insulin; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Leucine Zippers; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Nitric Oxide Synthase; Okadaic Acid; Oligonucleotides; Proto-Oncogene Proteins c-jun; Rats; Receptors, Interleukin-1; Signal Transduction; Sphingomyelins; Sphingosine; Transcription Factors; Type C Phospholipases

1996
Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway.
    Journal of neurochemistry, 1996, Volume: 66, Issue:4

    Topics: Alkaloids; Animals; Apoptosis; Cells, Cultured; Ceramides; Chick Embryo; DNA Damage; Enzyme Inhibitors; Neurons; Protein Kinase C; Sphingomyelins; Sphingosine; Staurosporine; Time Factors

1996
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate.
    Nature, 1996, Jun-27, Volume: 381, Issue:6585

    Topics: 3T3 Cells; Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Ceramides; DNA Damage; Enzyme Activation; fas Receptor; HL-60 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Lysophospholipids; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitosis; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Signal Transduction; Sphingosine; Tumor Necrosis Factor-alpha

1996
A novel enzyme that catalyzes the esterification of N-acetylsphingosine. Metabolism of C2-ceramides.
    The Journal of biological chemistry, 1996, Jun-14, Volume: 271, Issue:24

    Topics: Acyltransferases; Animals; Catalysis; Cell Line; Ceramides; Dogs; Esters; Kidney; Kinetics; Liposomes; Mice; Sphingosine; Substrate Specificity

1996
Tumor necrosis factor-alpha and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles.
    Endocrinology, 1996, Volume: 137, Issue:11

    Topics: Animals; Apoptosis; Cells, Cultured; Ceramides; Diethylstilbestrol; DNA; Drug Implants; Female; Follicle Stimulating Hormone; Gold Sodium Thiomalate; Humans; Mice; Ovarian Follicle; Progesterone; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Second Messenger Systems; Sphingosine; Tumor Necrosis Factor-alpha

1996
Ceramide induces apoptosis via CPP32 activation.
    FEBS letters, 1996, Oct-21, Volume: 395, Issue:2-3

    Topics: Apoptosis; Caspase 1; Caspase 3; Caspases; Ceramides; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme Precursors; Humans; Jurkat Cells; Kinetics; Oligopeptides; Protease Inhibitors; Sphingosine

1996
Cross-talk between ceramide and PKC activity in the control of apoptosis in WEHI-231.
    Advances in experimental medicine and biology, 1996, Volume: 406

    Topics: Alkaloids; Animals; Apoptosis; Benzophenanthridines; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Lymphoma, B-Cell; Mice; Naphthalenes; Phenanthridines; Protein Kinase C; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Tumor Cells, Cultured

1996
Cell-permeable ceramide inhibits the growth of B lymphoma Raji cells lacking TNF-alpha-receptors by inducing G0/G1 arrest but not apoptosis: a new model for dissecting cell-cycle arrest and apoptosis.
    Leukemia, 1996, Volume: 10, Issue:12

    Topics: Apoptosis; Cell Division; Cell Membrane Permeability; Drug Resistance, Neoplasm; Enzyme Inhibitors; G1 Phase; HL-60 Cells; Humans; Immunoblotting; Lymphoma, B-Cell; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Receptors, Tumor Necrosis Factor; Resting Phase, Cell Cycle; Retinoblastoma Protein; Sphingosine; Tumor Necrosis Factor-alpha

1996
Sphingosine-induced inhibition of capacitative calcium influx in CFPAC-1 cells.
    Cell calcium, 1996, Volume: 20, Issue:5

    Topics: Adenocarcinoma; Biological Transport; Calcium; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Humans; Manganese; Membrane Potentials; Mitochondria; Oligomycins; Pancreatic Ducts; Pancreatic Neoplasms; Propidium; Rhodamine 123; Rhodamines; Rotenone; Sphingosine; Thapsigargin; Tumor Cells, Cultured; Uncoupling Agents; Uridine Diphosphate

1996
Ceramide inhibits IgG-dependent phagocytosis in human polymorphonuclear leukocytes.
    Blood, 1997, Mar-15, Volume: 89, Issue:6

    Topics: Ceramides; Chemotaxis, Leukocyte; Erythrocytes; Glycerophospholipids; Humans; Immunoglobulin G; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phagocytosis; Phosphatidic Acids; Sphingomyelin Phosphodiesterase; Sphingosine; Time Factors

1997
Loss of ceramide production confers resistance to radiation-induced apoptosis.
    Cancer research, 1997, Apr-01, Volume: 57, Issue:7

    Topics: Alkaloids; Amidohydrolases; Animals; Apoptosis; Benzophenanthridines; Cell Division; Cell Nucleus; Cell Survival; Cells, Cultured; Ceramidases; Ceramides; Dose-Response Relationship, Radiation; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Lymphocytes; Mice; Oleic Acids; Phenanthridines; Sphingosine; Time Factors

1997
Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione.
    The Journal of biological chemistry, 1997, Apr-25, Volume: 272, Issue:17

    Topics: Animals; Cells, Cultured; Ceramides; Diglycerides; Dose-Response Relationship, Drug; Electron Transport; Glutathione; Hydrogen Peroxide; Liver; Mitochondria, Liver; Permeability; Rats; Reactive Oxygen Species; Second Messenger Systems; Sphingolipids; Sphingosine; Structure-Activity Relationship; Tumor Necrosis Factor-alpha

1997
Activation of CPP32 during apoptosis of neurons and astrocytes.
    Journal of neuroscience research, 1997, Apr-15, Volume: 48, Issue:2

    Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Astrocytes; Bisbenzimidazole; Caspase 3; Caspases; Cell-Free System; Cells, Cultured; Culture Media, Serum-Free; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Mice; Mice, Inbred Strains; Neurons; Poly(ADP-ribose) Polymerases; Sphingosine; Staurosporine

1997
Induction of oligodendrocyte apoptosis by C2-ceramide.
    Neurochemical research, 1997, Volume: 22, Issue:4

    Topics: Animals; Apoptosis; Brain; Cattle; Cells, Cultured; Diglycerides; DNA Fragmentation; Kinetics; Microscopy, Electron; Oligodendroglia; Phospholipases A; Sphingomyelin Phosphodiesterase; Sphingosine; Tetradecanoylphorbol Acetate; Type C Phospholipases

1997
Ceramide generation in response to photodynamic treatment of L5178Y mouse lymphoma cells.
    Cancer research, 1997, May-01, Volume: 57, Issue:9

    Topics: Animals; Apoptosis; Ceramides; DNA Fragmentation; Leukemia L5178; Mice; Photochemotherapy; Sphingosine; Time Factors

1997
Sphingosine induces apoptosis in androgen-independent human prostatic carcinoma DU-145 cells by suppression of bcl-X(L) gene expression.
    FEBS letters, 1997, Apr-21, Volume: 407, Issue:1

    Topics: Androgens; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Carcinoma; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; Male; Prostatic Neoplasms; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Sphingosine; Staurosporine

1997
C2-ceramide and C6-ceramide inhibited priming for enhanced release of superoxide in monocytes, but had no effect on the killing of leukaemic cells by monocytes.
    Immunology, 1997, Volume: 90, Issue:4

    Topics: Ceramides; Cytotoxicity, Immunologic; Humans; Interferon-gamma; Interleukin-1; Leukemia; Lipopolysaccharides; Monocytes; Sphingosine; Superoxides; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1997
Inhibitory action of sphingosine or ceramide on amylase secretion from isolated rat pancreatic acini.
    Biochemical and biophysical research communications, 1997, Jun-09, Volume: 235, Issue:1

    Topics: Amylases; Animals; Calcimycin; Carbachol; In Vitro Techniques; Male; Pancreas; Rats; Rats, Wistar; Sincalide; Sodium Fluoride; Sphingosine; Tetradecanoylphorbol Acetate

1997
Ceramide-mediated and isoquinolinesulfonamide-sensitive pathways of neuronal death: anything in common?
    Neurochemistry international, 1997, Volume: 31, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Death; Cells, Cultured; Enzyme Inhibitors; Isoquinolines; Neurons; Rats; Sphingosine; Sulfonamides

1997
Regulation of lipid signaling pathways for cell survival and apoptosis by bcl-2 in prostate carcinoma cells.
    Experimental cell research, 1997, Aug-01, Volume: 234, Issue:2

    Topics: Animals; Apoptosis; Arachidonic Acid; Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Humans; Hydroxyeicosatetraenoic Acids; JNK Mitogen-Activated Protein Kinases; Lipid Metabolism; Male; Mitogen-Activated Protein Kinases; Naphthalenes; Prostatic Neoplasms; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Rats; Signal Transduction; Sphingosine; Transfection; Tumor Cells, Cultured

1997
Bcl-2 antagonizes apoptotic cell death induced by two new ceramide analogues.
    FEBS letters, 1997, Jul-14, Volume: 411, Issue:2-3

    Topics: Amides; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Survival; Ceramides; Etoposide; Genes, bcl-2; Humans; Molecular Structure; Poly(ADP-ribose) Polymerases; Sphingosine; Transfection; Trypan Blue; Tumor Cells, Cultured

1997
Induction of apoptosis and potentiation of TNF- and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609.
    Experimental cell research, 1997, Aug-25, Volume: 235, Issue:1

    Topics: Antibodies, Monoclonal; Antigens, CD; Antineoplastic Agents; Apoptosis; Arachidonic Acid; Bridged-Ring Compounds; Chromatin; Culture Media, Serum-Free; DNA Fragmentation; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; fas Receptor; Humans; Kinetics; Leukemia, Myeloid; Norbornanes; Nucleosomes; Recombinant Proteins; Sphingomyelin Phosphodiesterase; Sphingosine; Tetradecanoylphorbol Acetate; Thiocarbamates; Thiones; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1997
Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I.
    Journal of neurochemistry, 1997, Volume: 69, Issue:3

    Topics: Actins; Animals; Apoptosis; Calpain; Cell Differentiation; Cell Survival; Ceramides; Enzyme Inhibitors; Kinetics; PC12 Cells; Rats; Sphingosine; tau Proteins; Tubulin

1997
Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide.
    The Journal of biological chemistry, 1997, Sep-26, Volume: 272, Issue:39

    Topics: Animals; Biological Transport; Cell Membrane Permeability; Electron Transport; Electron Transport Complex III; Glutamic Acid; HL-60 Cells; Humans; Mitochondria, Heart; Mitochondria, Muscle; Oxidative Phosphorylation; Rats; Sphingosine; Tumor Necrosis Factor-alpha

1997
Tumor necrosis factor-alpha autoregulates interleukin-6 synthesis via activation of protein kinase C. Function of sphingosine 1-phosphate and phosphatidylcholine-specific phospholipase C.
    The Journal of biological chemistry, 1997, Oct-03, Volume: 272, Issue:40

    Topics: 3T3 Cells; Animals; Bridged-Ring Compounds; Choline; Diglycerides; Enzyme Activation; Homeostasis; Inositol Phosphates; Interleukin-6; Kinetics; Lysophospholipids; Mice; Norbornanes; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Phosphorylcholine; Protein Kinase C; Sphingosine; Thiocarbamates; Thiones; Tumor Necrosis Factor-alpha; Type C Phospholipases

1997
Inhibition of TSH-induced hydrogen peroxide production by TNF-alpha through a sphingomyelinase signaling pathway.
    The American journal of physiology, 1997, Volume: 273, Issue:3 Pt 1

    Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Hydrogen Peroxide; Ionomycin; Kinetics; Sphingomyelin Phosphodiesterase; Sphingosine; Thapsigargin; Thyroid Gland; Thyrotropin; Tumor Necrosis Factor-alpha

1997
Insulin-like growth factor-binding protein (IGFBP-3) predisposes breast cancer cells to programmed cell death in a non-IGF-dependent manner.
    The Journal of biological chemistry, 1997, Oct-10, Volume: 272, Issue:41

    Topics: Apoptosis; Breast Neoplasms; Enzyme Inhibitors; Female; Flow Cytometry; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Signal Transduction; Sphingosine; Tumor Cells, Cultured

1997
Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration.
    Journal of neuroscience research, 1997, Sep-15, Volume: 49, Issue:6

    Topics: Animals; Apoptosis; Cells, Cultured; DNA; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; Hippocampus; Lipid Peroxidation; Neurons; NF-kappa B; Nitrates; Nitrogen Compounds; Oxidants; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sphingosine; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Tyrosine; Uric Acid

1997
Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion.
    The American journal of pathology, 1997, Volume: 151, Issue:5

    Topics: Animals; Apoptosis; Cells, Cultured; Ceramides; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Sprague-Dawley; Sphingosine

1997
The sphingomyelin-ceramide pathway participates in cytokine regulation of C-reactive protein and serum amyloid A, but not alpha-fibrinogen.
    The Biochemical journal, 1997, Nov-15, Volume: 328 ( Pt 1)

    Topics: Apolipoproteins; Bridged-Ring Compounds; C-Reactive Protein; Carcinoma, Hepatocellular; Ceramides; Fibrinogen; Humans; Interleukin-1; Interleukin-6; Norbornanes; RNA, Messenger; Serum Amyloid A Protein; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Thiocarbamates; Thiones; Tumor Cells, Cultured

1997
Vitamin D3 and ceramide reduce the invasion of tumor cells through extracellular matrix components by elevating protein phosphatase-2A.
    Invasion & metastasis, 1996, Volume: 16, Issue:6

    Topics: Animals; Blotting, Western; Cholecalciferol; Enzyme Activation; Extracellular Matrix; Humans; Laminin; Lung Neoplasms; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Okadaic Acid; Phosphoprotein Phosphatases; Protein Phosphatase 2; Sphingosine; Transfection; Vitronectin

1996
Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo.
    Cancer research, 1997, Nov-15, Volume: 57, Issue:22

    Topics: Animals; Apoptosis; Dexamethasone; DNA, Complementary; Enzyme Inhibitors; Humans; Mice; Mice, SCID; Neoplasm Proteins; Sphingosine; Staurosporine; Thapsigargin; Thioredoxins; Transfection; Tumor Cells, Cultured

1997
Ceramide promotes calpain-mediated proteolysis of protein kinase C beta in murine polymorphonuclear leukocytes.
    Biochemical and biophysical research communications, 1998, Jan-06, Volume: 242, Issue:1

    Topics: Animals; Calpain; Cysteine Proteinase Inhibitors; Down-Regulation; Isoenzymes; Leucine; Mice; Mice, Inbred C57BL; Neutrophils; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Sphingosine

1998
Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes.
    The Journal of biological chemistry, 1998, Jan-30, Volume: 273, Issue:5

    Topics: Apoptosis; Caspase 3; Caspase 6; Caspase 7; Caspases; Cysteine Endopeptidases; Enzyme Activation; fas Receptor; Humans; Jurkat Cells; Lamin Type B; Lamins; Lysophospholipids; Models, Biological; Nuclear Proteins; Poly Adenosine Diphosphate Ribose; Signal Transduction; Sphingosine; T-Lymphocytes; Tetradecanoylphorbol Acetate

1998
Effect of TNF-alpha on SMIT mRNA levels and myo-inositol accumulation in cultured endothelial cells.
    The American journal of physiology, 1998, Volume: 274, Issue:1

    Topics: Animals; Aorta; Carrier Proteins; Cattle; Cells, Cultured; Cerebrovascular Circulation; Cytokines; Endothelium, Vascular; Growth Substances; Heat-Shock Proteins; Humans; Inositol; Kinetics; Membrane Proteins; Mice; Microcirculation; Pulmonary Artery; Sphingosine; Symporters; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1998
BCR-ABL accelerates C2-ceramide-induced apoptosis.
    Oncogene, 1998, Jan-15, Volume: 16, Issue:2

    Topics: Apoptosis; Cell Division; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphorylation; Sphingosine; Tumor Necrosis Factor-alpha; Tyrosine

1998
Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase.
    The Journal of biological chemistry, 1998, Feb-27, Volume: 273, Issue:9

    Topics: Antibodies; Apoptosis; Biological Transport; CCAAT-Enhancer-Binding Proteins; Cell Nucleus; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Endopeptidases; Enzyme Activation; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation; Humans; Liver; Models, Biological; Nuclear Proteins; Protein Binding; Protein Processing, Post-Translational; Regulatory Sequences, Nucleic Acid; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Sterol Regulatory Element Binding Protein 1; Transcription Factors; Tumor Necrosis Factor-alpha

1998
Enhancement of fibroblast collagenase (matrix metalloproteinase-1) gene expression by ceramide is mediated by extracellular signal-regulated and stress-activated protein kinase pathways.
    The Journal of biological chemistry, 1998, Feb-27, Volume: 273, Issue:9

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Ceramides; Collagenases; Extracellular Matrix; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Transcription Factor AP-1; Tumor Necrosis Factor-alpha

1998
Exogenous C2-ceramide activates c-fos serum response element via Rac-dependent signalling pathway.
    The Biochemical journal, 1998, Mar-01, Volume: 330 ( Pt 2)

    Topics: Animals; Arachidonic Acid; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; GTP Phosphohydrolases; GTP-Binding Proteins; Nuclear Proteins; Phospholipases A; Phospholipases A2; rac GTP-Binding Proteins; Rats; Serum Response Factor; Signal Transduction; Sphingosine; Transcription Factors; Transfection

1998
Effects of alpha- and beta-galactosylated C2-ceramides on the immune system.
    Journal of medicinal chemistry, 1998, Feb-12, Volume: 41, Issue:4

    Topics: Adjuvants, Immunologic; Animals; Female; Galactosides; Immunosuppressive Agents; Lymphocyte Culture Test, Mixed; Lymphocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Molecular; Molecular Conformation; Molecular Structure; Sphingosine; Spleen; Structure-Activity Relationship

1998
Membrane-destabilizing properties of C2-ceramide may be responsible for its ability to inhibit platelet aggregation.
    Biochemistry, 1998, Feb-17, Volume: 37, Issue:7

    Topics: Adenine; Blood Platelets; Cell Membrane Permeability; Humans; Membrane Fluidity; Microscopy, Electron, Scanning; Platelet Aggregation; Platelet Aggregation Inhibitors; Pseudopodia; Sphingosine

1998
Sphingomyelinase and ceramide inhibit formation of F-actin ring in and bone resorption by rabbit mature osteoclasts.
    FEBS letters, 1998, Jan-30, Volume: 422, Issue:2

    Topics: Actins; Animals; Animals, Newborn; Apoptosis; Bone Resorption; Cells, Cultured; Enzyme Inhibitors; Lysophospholipids; Osteoclasts; Rabbits; Sphingomyelin Phosphodiesterase; Sphingosine

1998
Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis.
    European journal of biochemistry, 1998, Jan-15, Volume: 251, Issue:1-2

    Topics: Ammonium Chloride; Animals; Apoptosis; Brefeldin A; Caspase 3; Caspases; Cell Compartmentation; Cyclopentanes; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endosomes; Enzyme Activation; Humans; Lysosomes; Mice; Oligopeptides; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Necrosis Factor-alpha

1998
Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Mar-31, Volume: 95, Issue:7

    Topics: Animals; Antibodies; Apoptosis; Chlorocebus aethiops; Enzyme Inhibitors; fas Receptor; Heat Stress Disorders; HeLa Cells; Herpes Simplex; Herpesvirus 1, Human; Humans; Osmotic Pressure; Species Specificity; Sphingosine; Tumor Necrosis Factor-alpha; Vero Cells

1998
Fas-induced apoptosis in rat thecal/interstitial cells signals through sphingomyelin-ceramide pathway.
    Endocrinology, 1998, Volume: 139, Issue:4

    Topics: Animals; Antibodies, Monoclonal; Apoptosis; Ceramides; Chromatography, High Pressure Liquid; DNA Fragmentation; fas Receptor; Female; Mass Spectrometry; Microscopy, Fluorescence; Rats; Rats, Wistar; Signal Transduction; Sphingomyelins; Sphingosine; Theca Cells

1998
Dual role of ceramide in the control of apoptosis following IL-2 withdrawal.
    Journal of immunology (Baltimore, Md. : 1950), 1998, Apr-01, Volume: 160, Issue:7

    Topics: Animals; Apoptosis; Cell Cycle; Cell Fractionation; Cell Line; Culture Media, Serum-Free; Diglycerides; Humans; Immunoblotting; Interleukin-2; Mice; Recombinant Proteins; Sphingosine; T-Lymphocytes, Cytotoxic

1998
Metabolism and apoptotic properties of elevated ceramide in HT29rev cells.
    The Biochemical journal, 1998, Apr-15, Volume: 331 ( Pt 2)

    Topics: Apoptosis; Ceramides; Colonic Neoplasms; DNA Fragmentation; Humans; Hydrolysis; Poly(ADP-ribose) Polymerases; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Tumor Cells, Cultured

1998
Decreased phospholipase D (PLD) activity in ceramide-induced apoptosis of human keratinocyte cell line HaCaT.
    The Journal of investigative dermatology, 1998, Volume: 110, Issue:4

    Topics: Apoptosis; Cell Line; Cell Nucleus; DNA; DNA Fragmentation; Enzyme Inhibitors; Humans; Keratinocytes; Phospholipase D; Sphingosine; Staining and Labeling

1998
Oxidized low density lipoprotein induces apoptosis in cultured human umbilical vein endothelial cells by common and unique mechanisms.
    The Journal of biological chemistry, 1998, Apr-17, Volume: 273, Issue:16

    Topics: Antioxidants; Apoptosis; Butylated Hydroxytoluene; Catalase; Cells, Cultured; Ceramides; Cholesterol; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Enzyme Activation; Fibroblast Growth Factor 2; Humans; Kinetics; Lipoproteins, LDL; Oxidation-Reduction; Sphingosine; Sterols; Superoxide Dismutase; Umbilical Veins

1998
Distinctive inhibitory activity of docosahexaenoic acid against sphingosine-induced apoptosis.
    Biochimica et biophysica acta, 1998, Apr-22, Volume: 1391, Issue:3

    Topics: Apoptosis; Arachidonic Acid; Arachidonic Acids; Docosahexaenoic Acids; HL-60 Cells; Humans; Phospholipases A; Phospholipases A2; Second Messenger Systems; Sphingosine

1998
Different effects of cell-permeable ceramide analogs on platelet activation.
    Biochemistry and molecular biology international, 1998, Volume: 44, Issue:3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Blood Platelets; Calcium; Ceramides; Diglycerides; Platelet Activation; Platelet Aggregation Inhibitors; Rabbits; Sphingomyelin Phosphodiesterase; Sphingosine; Thrombin

1998
An accessory role for ceramide in interleukin-1beta induced prostaglandin synthesis.
    Molecular and cellular biochemistry, 1998, Volume: 181, Issue:1-2

    Topics: Alternative Splicing; Arachidonic Acid; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Isoenzymes; Membrane Proteins; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Sphingosine

1998
Transforming growth factor beta1 attenuates ceramide-induced CPP32/Yama activation and apoptosis in human leukaemic HL-60 cells.
    The Biochemical journal, 1997, Nov-01, Volume: 327 ( Pt 3)

    Topics: Apoptosis; Caspase 3; Caspases; Cell Cycle Proteins; Ceramides; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; HL-60 Cells; Humans; Microtubule-Associated Proteins; Oligopeptides; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Sphingomyelin Phosphodiesterase; Sphingosine; Transforming Growth Factor beta; Tumor Suppressor Proteins

1997
Epigenetic control of programmed cell death: inhibition by 5-azacytidine of 1,25-dihydroxyvitamin D3-induced programmed cell death in C6.9 glioma cells.
    Mechanisms of ageing and development, 1998, Mar-16, Volume: 101, Issue:1-2

    Topics: Animals; Apoptosis; Azacitidine; Calcitriol; Decitabine; DNA Fragmentation; DNA Modification Methylases; Enzyme Inhibitors; Genes, myc; Glioma; Rats; Sphingosine; Tumor Cells, Cultured

1998
Caspase activation is an early event in anthracycline-induced apoptosis and allows detection of apoptotic cells before they are ingested by phagocytes.
    Experimental cell research, 1998, May-01, Volume: 240, Issue:2

    Topics: Animals; Annexin A5; Antibiotics, Antineoplastic; Apoptosis; Caspase 3; Caspases; CD36 Antigens; CHO Cells; Coumarins; Cricetinae; Cysteine Endopeptidases; Daunorubicin; Enzyme Activation; Enzyme Inhibitors; Fluorescent Dyes; HL-60 Cells; Humans; Oligopeptides; Phagocytes; Phagocytosis; Sphingosine; Substrate Specificity; Tumor Cells, Cultured

1998
Apoptosis induction in synovial fibroblasts by ceramide: in vitro and in vivo effects.
    The Journal of laboratory and clinical medicine, 1998, Volume: 131, Issue:5

    Topics: Animals; Apoptosis; Arthritis, Rheumatoid; Fibroblasts; Humans; Injections, Intra-Articular; Male; Mice; Mice, Inbred MRL lpr; Reference Values; Sphingosine; Synovial Membrane

1998
Ceramide activates NFkappaB by inducing the processing of p105.
    The Journal of biological chemistry, 1998, Jun-19, Volume: 273, Issue:25

    Topics: DNA; DNA-Binding Proteins; Gene Expression Regulation; HL-60 Cells; Humans; I-kappa B Proteins; Jurkat Cells; NF-kappa B; NF-kappa B p50 Subunit; NF-KappaB Inhibitor alpha; Phosphorylation; Protein Precursors; Sphingosine; Transcriptional Activation; Transfection

1998
Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis.
    The Journal of biological chemistry, 1998, Jun-26, Volume: 273, Issue:26

    Topics: Animals; Apoptosis; Cell Membrane Permeability; COS Cells; Enzyme Inhibitors; Motor Neurons; Okadaic Acid; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sphingosine; Tumor Cells, Cultured

1998
In vitro thymocyte maturation is associated with reduced cellular susceptibility to Fas-mediated apoptosis.
    Cellular immunology, 1998, May-01, Volume: 185, Issue:2

    Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; bcl-X Protein; Carrier Proteins; Cell Differentiation; Cell Separation; Cells, Cultured; Cold Temperature; fas Receptor; Fas-Associated Death Domain Protein; Female; Hot Temperature; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sphingosine; T-Lymphocytes; Thymus Gland

1998
Neurotrophic factors prevent ceramide-induced apoptosis downstream of c-Jun N-terminal kinase activation in PC12 cells.
    Journal of neurochemistry, 1998, Volume: 71, Issue:1

    Topics: Amino Acid Chloromethyl Ketones; Androstadienes; Animals; Apoptosis; Cell Survival; Chromones; Cyclic AMP; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblast Growth Factor 2; Flavonoids; Hypoglycemic Agents; Insulin; Morpholines; Nerve Growth Factors; Neurons; Neuropeptides; Neuroprotective Agents; PC12 Cells; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-jun; Rats; Sphingosine; Thionucleotides; Wortmannin

1998
A comparison of the effects of lipopolysaccharide and ceramide on arachidonic acid metabolism in THP-1 monocytic cells.
    Cellular immunology, 1998, Jun-15, Volume: 186, Issue:2

    Topics: Arachidonic Acid; Cell Line; Dinoprostone; Humans; Leukotriene C4; Lipopolysaccharides; Monocytes; Sphingomyelin Phosphodiesterase; Sphingosine

1998
The role of the endothelium in ceramide-induced vasodilation.
    European journal of pharmacology, 1998, May-22, Volume: 349, Issue:2-3

    Topics: Animals; Aorta; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Methylene Blue; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Sprague-Dawley; Sphingosine; Vasodilation

1998
p75 and TrkA receptor signaling independently regulate amyloid precursor protein mRNA expression, isoform composition, and protein secretion in PC12 cells.
    Journal of neurochemistry, 1998, Volume: 71, Issue:2

    Topics: Amyloid beta-Protein Precursor; Animals; Antibodies, Monoclonal; Antioxidants; Blood Proteins; Blotting, Northern; Brain-Derived Neurotrophic Factor; Cell Death; Cholinergic Agents; Cross-Linking Reagents; Enzyme Inhibitors; Gene Expression Regulation; Immunotoxins; Isomerism; N-Glycosyl Hydrolases; Nerve Growth Factors; PC12 Cells; Proto-Oncogene Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Nerve Growth Factor; Receptor, trkA; Receptors, Nerve Growth Factor; Ribosome Inactivating Proteins, Type 1; RNA, Messenger; Saporins; Signal Transduction; Sphingosine

1998
The mitogen-activated protein kinase pathway inhibits ceramide-induced terminal differentiation of a human monoblastic leukemia cell line, U937.
    Journal of immunology (Baltimore, Md. : 1950), 1998, Aug-01, Volume: 161, Issue:3

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Activation; Humans; Leukemia, Monocytic, Acute; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phenotype; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Retinoblastoma Protein; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1998
Purification and characterization of ceramide-activated protein phosphatases.
    Biochemistry, 1998, Aug-11, Volume: 37, Issue:32

    Topics: Animals; Blotting, Western; Brain; Ceramides; Chromatography, Agarose; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Phosphoprotein Phosphatases; Rats; Sepharose; Sphingosine

1998
Positive feedback control of neutral sphingomyelinase activity by ceramide.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1998, Volume: 12, Issue:11

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane Permeability; Cells, Cultured; Ceramides; Daunorubicin; Enzyme Activation; Fibroblasts; HL-60 Cells; Humans; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Cells, Cultured

1998
Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.
    Molecular and cellular biology, 1998, Volume: 18, Issue:9

    Topics: 3T3 Cells; Adipocytes; Animals; Biological Transport; Cell Differentiation; Ceramides; Enzyme Inhibitors; Glucose; Glucose Transporter Type 4; Insulin; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Sphingosine; Transfection

1998
Regulation of membrane release in apoptosis.
    The Biochemical journal, 1998, Sep-01, Volume: 334 ( Pt 2)

    Topics: Apoptosis; Arachidonic Acid; Cell Membrane; Cysteine Proteinase Inhibitors; Etoposide; HL-60 Cells; Humans; Kinetics; Leukemia, B-Cell; Membrane Lipids; Palmitic Acid; Phospholipases A; Phospholipases A2; Preleukemia; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Sphingosine; Transfection; Tumor Cells, Cultured; Vincristine

1998
Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic.
    Journal of neurochemistry, 1998, Volume: 71, Issue:3

    Topics: Animals; Apoptosis; Astrocytes; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Free Radical Scavengers; Metalloporphyrins; Neurons; Rats; Sphingosine; Staurosporine; Superoxide Dismutase

1998
Lipopolysaccharide and ceramide use divergent signaling pathways to induce cell death in murine macrophages.
    Journal of immunology (Baltimore, Md. : 1950), 1998, Sep-01, Volume: 161, Issue:5

    Topics: Animals; Apoptosis; Cell Death; Cytotoxicity, Immunologic; DNA-Binding Proteins; Drug Synergism; Female; Interferon Regulatory Factor-1; Interferon-gamma; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C3H; Mice, Knockout; Necrosis; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphoproteins; Signal Transduction; Sphingosine; Tumor Necrosis Factor-alpha

1998
Radio-sensitive murine thymoma cell line 3SB: characterization of its apoptosis-resistant variants induced by repeated X-irradiation.
    Mutation research, 1998, Jul-17, Volume: 403, Issue:1-2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Daunorubicin; Drug Resistance; Genetic Variation; Methyl Methanesulfonate; Mice; Mitomycin; Mutagens; Radiation Tolerance; Sphingosine; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1998
Apoptotic damage of DNA in human leukaemic HL-60 cells treated with C2-ceramide was detected after G1 blockade of the cell cycle.
    Physiological research, 1997, Volume: 46, Issue:2

    Topics: Apoptosis; Cell Cycle; Cell Separation; DNA Damage; Enzyme Inhibitors; Flow Cytometry; G1 Phase; HL-60 Cells; Humans; Sphingosine

1997
Activation of Fas ligand/receptor system kills ovarian cancer cell lines by an apoptotic mechanism.
    Gynecologic oncology, 1998, Volume: 70, Issue:2

    Topics: Antibodies, Monoclonal; Apoptosis; Enzyme Inhibitors; fas Receptor; Female; Humans; Hydrolysis; Ovarian Neoplasms; Receptors, Tumor Necrosis Factor; Sphingomyelins; Sphingosine; Tumor Cells, Cultured

1998
Induction of programmed cell death in human retinoblastoma Y79 cells by C2-ceramide.
    Molecular and cellular biochemistry, 1998, Volume: 185, Issue:1-2

    Topics: Apoptosis; Bacterial Proteins; Blotting, Western; Cell Survival; Ceramides; DNA Fragmentation; Humans; Interleukin-1; Nucleosomes; Okadaic Acid; Proteins; Proto-Oncogene Proteins c-bcl-2; Retinoblastoma; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1998
Glucosylceramide synthase inhibitor inhibits the action of nerve growth factor in PC12 cells.
    The Journal of biological chemistry, 1998, Oct-02, Volume: 273, Issue:40

    Topics: Animals; Cell Differentiation; Drosophila Proteins; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Gangliosides; Glucosyltransferases; Glycosphingolipids; Insect Proteins; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Morpholines; Nerve Growth Factors; Neurons; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Rats; Signal Transduction; Sphingosine

1998
Src kinase and PI 3-kinase as a transduction pathway in ceramide-induced contraction of colonic smooth muscle.
    The American journal of physiology, 1998, Volume: 275, Issue:4

    Topics: Amino Acid Sequence; Androstadienes; Animals; Benzoquinones; Calcium; Chromones; Colon; Egtazic Acid; Enzyme Inhibitors; In Vitro Techniques; Kinetics; Lactams, Macrocyclic; Models, Biological; Molecular Sequence Data; Morpholines; Muscle Contraction; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Quinones; Rabbits; Rifabutin; Signal Transduction; Sphingosine; src Homology Domains; Substrate Specificity; Wortmannin

1998
The effects of ceramide and its analogues on the secretion of the mucocyst content of Tetrahymena.
    Cellular and molecular biology (Noisy-le-Grand, France), 1998, Volume: 44, Issue:6

    Topics: Animals; Antibodies, Monoclonal; Ceramides; Dibucaine; Female; Fluorescence; Lectins; Lysophospholipids; Mice; Mice, Inbred BALB C; Porifera; Psychosine; Sphingomyelins; Sphingosine; Tetrahymena pyriformis

1998
Apoptosis and activation of the sphingomyelin-ceramide pathway induced by oxidized low density lipoproteins are not causally related in ECV-304 endothelial cells.
    The Journal of biological chemistry, 1998, Oct-16, Volume: 273, Issue:42

    Topics: Apoptosis; Arteriosclerosis; Calcium; Cell Division; Cell Line; Ceramides; Endothelium, Vascular; Humans; Hydrolysis; Lipoproteins, LDL; Serine Proteinase Inhibitors; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Umbilical Veins

1998
Inhibition of skin carcinomas but not papillomas by sphingosine, N-methylsphingosine, and N-acetylsphingosine.
    Nutrition and cancer, 1998, Volume: 31, Issue:2

    Topics: Amines; Animals; Antineoplastic Agents; Carcinoma; Dermatologic Agents; Disease-Free Survival; Female; Mice; Mice, Inbred SENCAR; Papilloma; Skin Neoplasms; Sphingosine

1998
Products of sphingolipid catabolism block activation of the p21-activated protein kinases in neutrophils.
    Journal of immunology (Baltimore, Md. : 1950), 1998, Oct-15, Volume: 161, Issue:8

    Topics: Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Humans; Neutrophil Activation; Neutrophils; p21-Activated Kinases; Protein Serine-Threonine Kinases; Signal Transduction; Sphingosine

1998
Ceramide, a mediator of interleukin 1, tumour necrosis factor alpha, as well as Fas receptor signalling, induces apoptosis of rheumatoid arthritis synovial cells.
    Annals of the rheumatic diseases, 1998, Volume: 57, Issue:8

    Topics: Apoptosis; Arthritis, Rheumatoid; Cell Culture Techniques; Cell Death; Cytokines; DNA; fas Receptor; Humans; Interleukin-1; Signal Transduction; Sphingosine; Synovial Membrane; Tumor Necrosis Factor-alpha

1998
Effects of endoglycoceramidase or D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol on glucose uptake, glycolysis, and mitochondrial respiration in HL60 cells.
    Archives of biochemistry and biophysics, 1998, Nov-01, Volume: 359, Issue:1

    Topics: Cell Membrane Permeability; Cell Respiration; Glucose; Glycolysis; Glycoside Hydrolases; HL-60 Cells; Humans; Intracellular Fluid; Mitochondria; Morpholines; Oxidation-Reduction; Sphingosine

1998
Distribution of protein phosphatases type 1 and 2A in RINm5F cells.
    Regulatory peptides, 1998, Oct-16, Volume: 77, Issue:1-3

    Topics: Animals; Biomarkers; Cell Fractionation; Chromosomal Proteins, Non-Histone; DNA-Binding Proteins; Enzyme Inhibitors; Heparin; Histone Chaperones; Islets of Langerhans; Okadaic Acid; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylase a; Protamines; Proteins; Rats; Sphingosine; Transcription Factors; Tumor Cells, Cultured

1998
Tumor necrosis factor-alpha-induced release of plasminogen activator inhibitor-1 from human umbilical vein endothelial cells: involvement of intracellular ceramide signaling event.
    Biochimica et biophysica acta, 1998, Nov-19, Volume: 1448, Issue:1

    Topics: Ceramides; DNA Fragmentation; Endosomes; Endothelium, Vascular; Humans; Lysosomes; Plasminogen Activator Inhibitor 1; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Necrosis Factor-alpha; Umbilical Veins

1998
Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Nov-24, Volume: 95, Issue:24

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; E-Selectin; Endothelium, Vascular; Enzyme Activation; Gene Expression Regulation; Humans; JNK Mitogen-Activated Protein Kinases; Kinetics; Lysophospholipids; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphotransferases (Alcohol Group Acceptor); Signal Transduction; Sphingomyelins; Sphingosine; Tumor Necrosis Factor-alpha; Umbilical Veins; Vascular Cell Adhesion Molecule-1

1998
Rho A regulates sustained smooth muscle contraction through cytoskeletal reorganization of HSP27.
    The American journal of physiology, 1998, Volume: 275, Issue:6

    Topics: ADP Ribose Transferases; Animals; Biological Transport; Botulinum Toxins; Colon; Cytoskeleton; Endothelin-1; GTP-Binding Proteins; Heat-Shock Proteins; Muscle Contraction; Muscle, Smooth; Phosphoinositide-3 Kinase Inhibitors; Rabbits; rhoA GTP-Binding Protein; Sphingosine; Tissue Distribution

1998
C2-ceramide attenuates prostaglandin F2alpha-induced vasoconstriction and elevation of [Ca2+]i in canine cerebral vascular smooth muscle.
    Neuroscience letters, 1998, Nov-06, Volume: 256, Issue:2

    Topics: Animals; Calcium; Cells, Cultured; Dinoprost; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Fura-2; In Vitro Techniques; Intracellular Fluid; Male; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Signal Transduction; Sphingosine; Time Factors; Vasoconstriction

1998
Ceramide and cyclic adenosine monophosphate (cAMP) induce cAMP response element binding protein phosphorylation via distinct signaling pathways while having opposite effects on myeloid cell survival.
    Blood, 1999, Jan-01, Volume: 93, Issue:1

    Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Survival; Ceramides; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Hematopoietic Stem Cells; Humans; Imidazoles; Interleukin-3; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Sphingosine; Tumor Necrosis Factor-alpha; U937 Cells

1999
Increased cyclin E level in retinoblastoma cells during programmed cell death.
    Cellular and molecular biology (Noisy-le-Grand, France), 1998, Volume: 44, Issue:8

    Topics: Amsacrine; Apoptosis; Camptothecin; Cyclin A; Cyclin E; Enzyme Inhibitors; Etoposide; Humans; Interleukin-1; Retinoblastoma; Sphingosine; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1998
Role of ceramide in lipopolysaccharide (LPS)-induced signaling. LPS increases ceramide rather than acting as a structural homolog.
    The Journal of biological chemistry, 1999, Jan-15, Volume: 274, Issue:3

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Ceramides; Dose-Response Relationship, Drug; Enzyme Activation; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Kinetics; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; Molecular Mimicry; NF-kappa B; Signal Transduction; Sphingosine; Tumor Necrosis Factor-alpha

1999
Aryl hydrocarbon receptor regulation of ceramide-induced apoptosis in murine hepatoma 1c1c7 cells. A function independent of aryl hydrocarbon receptor nuclear translocator.
    The Journal of biological chemistry, 1999, Jan-22, Volume: 274, Issue:4

    Topics: Animals; Apoptosis; Aryl Hydrocarbon Receptor Nuclear Translocator; DNA-Binding Proteins; Doxorubicin; Liver Neoplasms, Experimental; Mice; Receptors, Aryl Hydrocarbon; Sphingosine; Staurosporine; Transcription Factors; Tumor Cells, Cultured

1999
N-Acetylsphingosine stimulates phosphatidylglycerolphosphate synthase activity in H9c2 cardiac cells.
    The Biochemical journal, 1999, Feb-01, Volume: 337 ( Pt 3)

    Topics: Animals; Cardiolipins; Cell Line; Cell Membrane Permeability; Ceramides; Cyclic AMP-Dependent Protein Kinases; DNA; Enzyme Activation; Enzyme Inhibitors; Ligases; Marine Toxins; Mitochondria, Heart; Myocardium; Nucleotides; Okadaic Acid; Oxazoles; Phosphatidylglycerols; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Rats; Sphingosine; Tumor Necrosis Factor-alpha

1999
Acyl chain length-specific ceramide-induced changes in intracellular Ca2+ concentration and progesterone production are not regulated by tumor necrosis factor alpha in hen granulosa cells.
    Biology of reproduction, 1999, Volume: 60, Issue:2

    Topics: Animals; Calcium; Carbachol; Ceramides; Chickens; Female; Granulosa Cells; Luteinizing Hormone; Progesterone; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Tumor Necrosis Factor-alpha

1999
Partial lithium-associated protection against apoptosis induced by C2-ceramide in cerebellar granule neurons.
    Neuroreport, 1998, Dec-21, Volume: 9, Issue:18

    Topics: Animals; Apoptosis; Cells, Cultured; Cerebellum; Drug Administration Schedule; Female; Inositol Phosphates; Lithium; Male; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Sphingosine

1998
Activation of integrin and ceramide signalling pathways can inhibit the mitogenic effect of insulin-like growth factor I (IGF-I) in human breast cancer cell lines.
    British journal of cancer, 1999, Volume: 79, Issue:5-6

    Topics: Breast Neoplasms; Cell Cycle; Cell Division; Cyclin A; Cyclin B; Cyclin B1; Female; Humans; Insulin-Like Growth Factor I; Kinetics; Oligopeptides; Recombinant Proteins; S Phase; Signal Transduction; Sphingosine; Tumor Cells, Cultured

1999
Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons.
    Brain research, 1999, Feb-20, Volume: 819, Issue:1-2

    Topics: Animals; Cell Survival; Cells, Cultured; Ceramides; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Glutamic Acid; Lysophospholipids; Mesencephalon; Neurons; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingosine; Time Factors; Tumor Necrosis Factor-alpha

1999
Limited role of ceramide in lipopolysaccharide-mediated mitogen-activated protein kinase activation, transcription factor induction, and cytokine release.
    The Journal of biological chemistry, 1999, Apr-02, Volume: 274, Issue:14

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Ceramides; Cytokines; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Signal Transduction; Sphingomyelins; Sphingosine; Transcription Factor AP-1; Transcription Factors

1999
Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2, 5-dibromophenyl)propenamide].
    The Journal of biological chemistry, 1999, Apr-02, Volume: 274, Issue:14

    Topics: Agammaglobulinaemia Tyrosine Kinase; Amides; Antineoplastic Agents; Computer Simulation; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; ErbB Receptors; Humans; Janus Kinase 1; Janus Kinase 2; Models, Molecular; Nitriles; Protein Conformation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, Insulin; Sphingosine; src-Family Kinases; Structure-Activity Relationship; Tumor Cells, Cultured; Vincristine

1999
Extended ceramide exposure activates the trkA receptor by increasing receptor homodimer formation.
    Journal of neurochemistry, 1999, Volume: 72, Issue:4

    Topics: 3T3 Cells; Animals; Cell Membrane; Dimerization; Enzyme Inhibitors; G(M1) Ganglioside; Mice; Nerve Growth Factors; Neurons; PC12 Cells; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Nerve Growth Factor; Receptor, trkA; Receptors, Nerve Growth Factor; Sphingosine

1999
The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme.
    Journal of neurochemistry, 1999, Volume: 72, Issue:4

    Topics: Animals; Astrocytes; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carnitine O-Palmitoyltransferase; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Dose-Response Relationship, Drug; Dronabinol; Enzyme Inhibitors; Ketone Bodies; Malonyl Coenzyme A; Mitochondria; Piperidines; Protein Kinase C; Psychotropic Drugs; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine

1999
Effect of C2 ceramide on the inositol phospholipid metabolism (uptake of 32P, 3H-serine and 3H-palmitic acid) and apoptosis-related morphological changes in Tetrahymena.
    Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1999, Volume: 122, Issue:2

    Topics: Animals; Apoptosis; Chromatin; DNA Fragmentation; Kinetics; Palmitic Acid; Phosphatidylinositols; Phosphorus Radioisotopes; Serine; Sphingosine; Tetrahymena; Tritium

1999
CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide.
    Molecular genetics and metabolism, 1999, Volume: 66, Issue:4

    Topics: Apoptosis; Blotting, Western; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Ceramides; Cyclins; Dose-Response Relationship, Drug; Etoposide; Humans; Membrane Glycoproteins; Models, Biological; Molecular Chaperones; Neurodegenerative Diseases; Poly(ADP-ribose) Polymerases; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae Proteins; Sphingosine; Staurosporine; Time Factors; Transfection; Vincristine

1999
Differential activation of phosphoinositide 3-kinase by endothelin and ceramide in colonic smooth muscle cells.
    The American journal of physiology, 1999, Volume: 276, Issue:4

    Topics: Animals; Calcium; Calcium Chloride; Cells, Cultured; Colon; Egtazic Acid; Endothelin-1; Enzyme Activation; Genistein; Kinetics; Models, Biological; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Rabbits; Signal Transduction; Sphingosine; Time Factors

1999
Fumonisin B1 induces apoptosis in cultured human keratinocytes through sphinganine accumulation and ceramide depletion.
    International journal of oncology, 1999, Volume: 14, Issue:5

    Topics: Apoptosis; beta-Alanine; Carboxylic Acids; Cell Survival; Cells, Cultured; Ceramides; Chromatography, High Pressure Liquid; Colony-Forming Units Assay; DNA Fragmentation; Drug Interactions; Enzyme Inhibitors; Fumonisins; Humans; Keratinocytes; Sphingolipids; Sphingosine; Teratogens

1999
The growth arrest and downregulation of c-myc transcription induced by ceramide are related events dependent on p21 induction, Rb underphosphorylation and E2F sequestering.
    Cell death and differentiation, 1998, Volume: 5, Issue:5

    Topics: Apoptosis; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Cell Line; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; E2F Transcription Factors; Gene Expression Regulation; Genes, myc; Genes, Reporter; Humans; Phosphorylation; Promoter Regions, Genetic; Retinoblastoma Protein; Retinoblastoma-Binding Protein 1; Sphingosine; Transcription Factor DP1; Transcription Factors; Transcription, Genetic; Transfection

1998
Hydrogen peroxide suppresses U937 cell death by two different mechanisms depending on its concentration.
    Experimental cell research, 1999, May-01, Volume: 248, Issue:2

    Topics: Adaptation, Biological; Antioxidants; Apoptosis; bcl-X Protein; Cell Death; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Induction; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Necrosis; Proto-Oncogene Proteins c-bcl-2; Sphingosine; Time Factors; U937 Cells

1999
FK506 prevents stroke-induced generation of ceramide and apoptosis signaling.
    Brain research, 1999, May-01, Volume: 826, Issue:2

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain Chemistry; Cerebrovascular Disorders; Enzyme Inhibitors; Fas Ligand Protein; Gene Expression; Humans; Immunosuppressive Agents; Ischemic Attack, Transient; Male; Membrane Glycoproteins; Necrosis; Neuroblastoma; Neurons; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Sphingosine; Tacrolimus; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Up-Regulation

1999
Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction.
    Current biology : CB, 1999, Apr-22, Volume: 9, Issue:8

    Topics: 3T3 Cells; Animals; Binding Sites; Blood Proteins; Cattle; Cell Communication; Cell Line; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Extracellular Matrix; Fetal Blood; Fluorescent Antibody Technique; Green Fluorescent Proteins; Insulin; Luminescent Proteins; Mice; Morpholines; Phosphatidylinositols; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Fusion Proteins; Sphingosine

1999
Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism.
    Oncogene, 1999, Apr-15, Volume: 18, Issue:15

    Topics: Amidohydrolases; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Cell Death; Ceramidases; Enzyme Inhibitors; Gamma Rays; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Myristates; Propanolamines; Protein Biosynthesis; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Sphingosine; Vidarabine

1999
Increase of MnSOD expression and decrease of JNK activity determine the TNF sensitivity in bcl2-transfected L929 cells.
    Cytokine, 1999, Volume: 11, Issue:4

    Topics: Animals; Apoptosis; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Nucleus; Dactinomycin; DNA Fragmentation; DNA Primers; Genes, bcl-2; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; RNA, Messenger; Sphingosine; Superoxide Dismutase; Transfection; Tumor Necrosis Factor-alpha

1999
Killing of T lymphocytes by synthetic ceramide is by a nonapoptotic mechanism and is abrogated following mitogenic activation.
    Experimental cell research, 1999, May-25, Volume: 249, Issue:1

    Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspases; Cell Death; Cells, Cultured; Cysteine Proteinase Inhibitors; Enzyme Activation; Humans; Jurkat Cells; Lymphocyte Activation; Mitogens; Neoplastic Stem Cells; Okadaic Acid; Phytohemagglutinins; Sphingosine; T-Lymphocytes

1999
Ceramide induces apoptosis to immature cerebellar granule cells in culture.
    Neurochemical research, 1999, Volume: 24, Issue:5

    Topics: Animals; Apoptosis; Cells, Cultured; Ceramides; Cerebellum; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Interleukin-1; Neurons; Nucleic Acid Synthesis Inhibitors; Protein Biosynthesis; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Time Factors; Tumor Necrosis Factor-alpha

1999
Helicobacter pylori-dependent ceramide production may mediate increased interleukin 8 expression in human gastric cancer cell lines.
    Gastroenterology, 1999, Volume: 116, Issue:6

    Topics: Ceramides; Enzyme Inhibitors; Helicobacter Infections; Helicobacter pylori; Humans; Interleukin-8; NF-kappa B; RNA, Messenger; Sphingomyelin Phosphodiesterase; Sphingosine; Stomach Neoplasms; Transcription Factor AP-1; Transcription, Genetic; Tumor Cells, Cultured

1999
Ceramide triggers p53-dependent apoptosis in genetically defined fibrosarcoma tumour cells.
    British journal of cancer, 1999, Volume: 80, Issue:5-6

    Topics: Animals; Apoptosis; Cell Cycle; Enzyme Inhibitors; Fibrosarcoma; Growth Inhibitors; Mice; Mice, Knockout; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1999
Induction and suppression of endothelial cell apoptosis by sphingolipids: a possible in vitro model for cell-cell interactions between platelets and endothelial cells.
    Blood, 1999, Jun-15, Volume: 93, Issue:12

    Topics: Acetic Anhydrides; Acylation; Apoptosis; Blood Platelets; Cell Communication; DNA; Endothelium, Vascular; Humans; Lysophospholipids; Microscopy, Fluorescence; Sphingolipids; Sphingosine; Umbilical Veins

1999
Effect of ceramide on KCa channel activity and vascular tone in coronary arteries.
    Hypertension (Dallas, Tex. : 1979), 1999, Volume: 33, Issue:6

    Topics: Animals; Calcium; Cattle; Coronary Vessels; Dithiothreitol; Enzyme Inhibitors; Glutathione; In Vitro Techniques; Kinetics; Membrane Potentials; Muscle Tonus; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Potassium Channels; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Vasoconstriction

1999
Increased, not decreased activation of the insulin-like growth factor (IGF) receptor signalling pathway during ceramide-induced apoptosis.
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 1999, Volume: 9, Issue:2

    Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Division; Cell Survival; Ceramides; Dose-Response Relationship, Drug; Fibroblasts; Flow Cytometry; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Receptor, IGF Type 1; Signal Transduction; Sphingosine; Time Factors

1999
Ceramide induces caspase-independent apoptosis in rat hepatocytes sensitized by inhibition of RNA synthesis.
    Hepatology (Baltimore, Md.), 1999, Volume: 30, Issue:1

    Topics: Animals; Apoptosis; Caspases; Cell Line; Cysteine Proteinase Inhibitors; Dactinomycin; Enzyme Inhibitors; Indoles; Liver; Male; NF-kappa B; Nucleic Acid Synthesis Inhibitors; Oligopeptides; Ploidies; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Sphingosine

1999
Inhibition of human erythroid colony formation by ceramide.
    Experimental hematology, 1999, Volume: 27, Issue:7

    Topics: Apoptosis; Ceramides; Colony-Forming Units Assay; Depression, Chemical; Erythroid Precursor Cells; Erythropoiesis; Erythropoietin; fas Receptor; Humans; Interferon-beta; Interferon-gamma; Lysophospholipids; Recombinant Proteins; Sphingomyelin Phosphodiesterase; Sphingosine

1999
Effect of ceramide on interleukin-6 synthesis in osteoblast-like cells.
    Cellular signalling, 1999, Volume: 11, Issue:6

    Topics: Alprostadil; Animals; Bucladesine; Calcimycin; Cell Line; Cholera Toxin; Colforsin; Dinoprost; Interleukin-1; Interleukin-6; Mice; Osteoblasts; Sphingosine; Tetradecanoylphorbol Acetate; Thapsigargin; Thrombin; Tumor Necrosis Factor-alpha

1999
Involvement of the 92-kDa gelatinase (matrix metalloproteinase-9) in the ceramide-mediated inhibition of human keratinocyte growth.
    Biochemical and biophysical research communications, 1999, Jul-14, Volume: 260, Issue:3

    Topics: Antibodies; Apoptosis; Cell Division; Cells, Cultured; Ceramides; Collagenases; Dose-Response Relationship, Drug; Epidermal Growth Factor; Gelatinases; HL-60 Cells; Humans; Keratinocytes; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Phenylalanine; Sphingomyelin Phosphodiesterase; Sphingosine; Thiophenes; Time Factors

1999
Tumor necrosis factor-alpha and ceramides in insulin resistance.
    Lipids, 1999, Volume: 34 Suppl

    Topics: 3T3 Cells; Adipocytes; Animals; Biological Transport; Ceramides; Deoxyglucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Kinetics; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Sphingosine; Tumor Necrosis Factor-alpha

1999
Induction of the manganese superoxide dismutase gene by sphingomyelinase and ceramide.
    Journal of neurochemistry, 1999, Volume: 73, Issue:2

    Topics: Animals; Antisense Elements (Genetics); Apoptosis; Astrocytes; Blotting, Northern; Cells, Cultured; Ceramides; Cerebral Cortex; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation, Enzymologic; Glomerular Mesangium; Humans; Interleukin-1; Lipopolysaccharides; Lysosomal Storage Diseases; Rats; RNA, Messenger; Skin; Sphingomyelin Phosphodiesterase; Sphingosine; Superoxide Dismutase; Tumor Necrosis Factor-alpha

1999
Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic PC12 cell death.
    Journal of neurochemistry, 1999, Volume: 73, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; Caspase 3; Caspases; Cell Death; Cell Differentiation; Cell Hypoxia; Ceramides; Enzyme Activation; Free Radical Scavengers; Glutathione; L-Lactate Dehydrogenase; Neurons; PC12 Cells; Rats; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine

1999
Differential modulation of apoptosis sensitivity in CD95 type I and type II cells.
    The Journal of biological chemistry, 1999, Aug-06, Volume: 274, Issue:32

    Topics: Adaptor Proteins, Signal Transducing; Apoptosis; B-Lymphocytes; Carrier Proteins; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cells, Cultured; Cycloheximide; Enzyme Activation; fas Receptor; Fas-Associated Death Domain Protein; Hematopoietic Stem Cells; Intracellular Signaling Peptides and Proteins; Models, Biological; Protein Kinase C; Signal Transduction; Sphingosine; T-Lymphocytes

1999
An essential role for mitogen-activated protein kinases, ERKs, in preventing heat-induced cell death.
    Journal of cellular biochemistry, 1999, Sep-15, Volume: 74, Issue:4

    Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Death; Enzyme Activation; HL-60 Cells; Hot Temperature; Humans; K562 Cells; Leukemia; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-raf; Sphingosine; Transfection; U937 Cells

1999
The role of cell surface attachment and proteolysis in the insulin-like growth factor (IGF)-independent effects of IGF-binding protein-3 on apoptosis in breast epithelial cells.
    Endocrinology, 1999, Volume: 140, Issue:9

    Topics: Animals; Apoptosis; Breast Neoplasms; Carcinoma; Cell Membrane; DNA Fragmentation; Drug Synergism; Epithelial Cells; Female; Humans; Insulin-Like Growth Factor Binding Protein 3; Peptide Hydrolases; Recombinant Proteins; Serine Proteinase Inhibitors; Somatomedins; Sphingosine; Sulfones; Tumor Cells, Cultured

1999
Ceramide-induced apoptosis occurs independently of caspases and is decreased by leupeptin.
    Cell death and differentiation, 1999, Volume: 6, Issue:8

    Topics: Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; fas Receptor; Female; Humans; Leupeptins; Necrosis; Sphingosine; Tumor Cells, Cultured; U937 Cells

1999
Characterization of Apt- cell lines exhibiting cross-resistance to glucocorticoid- and Fas-mediated apoptosis.
    Cell death and differentiation, 1999, Volume: 6, Issue:8

    Topics: Animals; Apoptosis; Caspases; Dexamethasone; Enzyme Inhibitors; fas Receptor; Glucocorticoids; Humans; Mice; Mutagenesis; Sphingosine; Staurosporine; Tumor Cells, Cultured

1999
Potentiation by vitamin D analogs of TNFalpha and ceramide-induced apoptosis in MCF-7 cells is associated with activation of cytosolic phospholipase A2.
    Cell death and differentiation, 1999, Volume: 6, Issue:9

    Topics: Antigens, CD; Apoptosis; Calcitriol; Cell Survival; Cytosol; Cytotoxicity, Immunologic; Drug Synergism; Enzyme Activation; Humans; Phospholipases A; Phospholipases A2; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Sphingosine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1999
Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.
    The Journal of cell biology, 1999, Nov-01, Volume: 147, Issue:3

    Topics: Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Division; Cell Line; Cell Survival; Cytosol; DNA; Enzyme Activation; fas Receptor; Humans; Lysophospholipids; Mice; Peptide Hydrolases; Pertussis Toxin; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Recombinant Fusion Proteins; Second Messenger Systems; Sphingosine; Transfection; Virulence Factors, Bordetella

1999
Effect of ceramide on apoptosis and phospholipase D activity in FRTL-5 thyroid cells.
    Experimental & molecular medicine, 1999, Sep-30, Volume: 31, Issue:3

    Topics: Animals; Apoptosis; Cells, Cultured; DNA Fragmentation; Enzyme Activation; Flow Cytometry; Gene Expression Regulation, Enzymologic; Phospholipase D; Rats; Rats, Inbred Strains; RNA, Messenger; Sphingosine; Thyroid Gland; Thyrotropin

1999
1-O-acylceramide synthase.
    Methods in enzymology, 2000, Volume: 311

    Topics: Acylation; Acyltransferases; Animals; Arachidonic Acid; Brain; Cattle; Cells, Cultured; Ceramides; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipases A2; Sphingolipids; Sphingosine

2000
Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism.
    FEBS letters, 1999, Sep-24, Volume: 458, Issue:3

    Topics: Annexin A5; Apoptosis; Benzoxazines; DNA Fragmentation; Dronabinol; Fluorescent Antibody Technique; Humans; Indoles; Male; Mitochondria; Morpholines; Naphthalenes; Pertussis Toxin; Piperidines; Prostatic Neoplasms; Protein Binding; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Sphingosine; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella

1999
Redistribution of cytochrome c is not an essential requirement in C2-ceramide induced apoptosis in HL-60 cells.
    Life sciences, 1999, Volume: 65, Issue:16

    Topics: Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cytochrome c Group; Enzyme Activation; Enzyme Inhibitors; HL-60 Cells; Humans; Proto-Oncogene Proteins c-bcl-2; Sodium Dodecyl Sulfate; Sphingosine

1999
Role of PI 3-kinase in angiopoietin-1-mediated migration and attachment-dependent survival of endothelial cells.
    Experimental cell research, 1999, Dec-15, Volume: 253, Issue:2

    Topics: Angiopoietin-1; Apoptosis; Cell Adhesion; Cell Movement; Cell Survival; Chromones; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Fibroblast Growth Factor 2; Humans; Lymphokines; Membrane Glycoproteins; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sphingosine; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

1999
Possible involvement of cytochrome c release and sequential activation of caspases in ceramide-induced apoptosis in SK-N-MC cells.
    Biochimica et biophysica acta, 1999, Dec-09, Volume: 1452, Issue:3

    Topics: Apoptosis; Caspase Inhibitors; Caspases; Cell-Free System; Cytochrome c Group; Cytosol; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Humans; L-Lactate Dehydrogenase; Neuroblastoma; Reverse Transcriptase Polymerase Chain Reaction; Sphingosine; Time Factors; Tumor Cells, Cultured

1999
Induction of apoptosis by novel synthesized acylamides of human lymphocytes.
    Biochimica et biophysica acta, 2000, Jan-03, Volume: 1483, Issue:1

    Topics: Alanine; Amides; Antibodies; Apoptosis; Caspase 3; Caspase Inhibitors; Cell Survival; DNA Fragmentation; Enzyme Inhibitors; Humans; Intracellular Membranes; Jurkat Cells; Lymphocytes; Membrane Potentials; Myristic Acids; Sphingosine; Structure-Activity Relationship

2000
Nerve growth factor stimulates MAPK via the low affinity receptor p75(LNTR).
    FEBS letters, 1999, Dec-17, Volume: 463, Issue:3

    Topics: Age Factors; Animals; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Neurons; Oncogene Protein p21(ras); Phosphorylation; Rats; Receptor, Nerve Growth Factor; Sphingosine

1999
p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis.
    Molecular and cellular biology, 2000, Volume: 20, Issue:2

    Topics: 14-3-3 Proteins; Animals; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Carrier Proteins; cdc42 GTP-Binding Protein; Cell Line; Cell Survival; Enzyme Activation; Interleukin-3; Mice; Mutation; p21-Activated Kinases; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphoserine; Protein Binding; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins c-bcl-2; rho GTP-Binding Proteins; Signal Transduction; Sphingosine; Tyrosine 3-Monooxygenase

2000
Indications for an active process underlying spontaneous and radiation-induced micronucleation in L929 cells.
    International journal of radiation biology, 1999, Volume: 75, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aurintricarboxylic Acid; Benzhydryl Compounds; Bromodeoxyuridine; Cell Division; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; DNA, Neoplasm; Electrophoresis, Gel, Pulsed-Field; Endonucleases; Enzyme Inhibitors; Fibrosarcoma; Mice; Micronuclei, Chromosome-Defective; Micronucleus Tests; Proliferating Cell Nuclear Antigen; Protein Kinase C; Spermine; Sphingosine; Teniposide; Topoisomerase II Inhibitors; Transcription, Genetic; Tumor Cells, Cultured

1999
Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage.
    Biochemical and biophysical research communications, 2000, Jan-07, Volume: 267, Issue:1

    Topics: Animals; Annexin A5; Apoptosis; Cartilage, Articular; Cells, Cultured; Ceramides; Collagenases; Interleukin-1; Kinetics; Male; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Phenylalanine; Protease Inhibitors; Proteoglycans; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; Sphingomyelin Phosphodiesterase; Sphingosine; Thiophenes; Transcription, Genetic

2000
Requirement of calmodulin binding by HIV-1 gp160 for enhanced FAS-mediated apoptosis.
    The Journal of biological chemistry, 2000, Jan-14, Volume: 275, Issue:2

    Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Apoptosis; Binding Sites; Calmodulin; Caspase 3; Caspases; Enzyme Activation; fas Receptor; HIV Envelope Protein gp160; HIV-1; Humans; Jurkat Cells; Models, Molecular; Molecular Sequence Data; Myosin-Light-Chain Kinase; Peptide Fragments; Point Mutation; Protein Structure, Secondary; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Sphingosine; Transfection; Tryptophan

2000
Lipid metabolic changes caused by short-chain ceramides and the connection with apoptosis.
    The Biochemical journal, 2000, Feb-01, Volume: 345 Pt 3

    Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Apoptosis; Boron Compounds; Cell Line; Ceramides; Cholesterol; Cricetinae; Fibroblasts; Kidney; Lipid Metabolism; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylserines; Sphingolipids; Sphingomyelins; Sphingosine

2000
Hypoxic preconditioning protects cultured neurons against hypoxic stress via TNF-alpha and ceramide.
    American journal of physiology. Cell physiology, 2000, Volume: 278, Issue:1

    Topics: Animals; Antigens, CD; Biomarkers; Brain Ischemia; Cell Count; Cell Hypoxia; Cell Survival; Cells, Cultured; Ceramides; Cerebral Cortex; Ischemic Preconditioning; Neurons; Oxygen; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Sphingosine; Tumor Necrosis Factor-alpha; Up-Regulation

2000
Caspases mediate C2-ceramide-induced apoptosis of the human oligodendroglial cell line, MO3.13.
    Neuroscience letters, 2000, Jan-14, Volume: 278, Issue:3

    Topics: Apoptosis; Carrier Proteins; Caspase 3; Caspases; Cell Line, Transformed; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Humans; Immunoblotting; Microfilament Proteins; Oligodendroglia; Sphingosine

2000
Effect of ceramide on intracellular glutathione determines apoptotic or necrotic cell death of JB6 tumor cells.
    Toxicological sciences : an official journal of the Society of Toxicology, 2000, Volume: 53, Issue:1

    Topics: Acetylcysteine; Animals; Apoptosis; Drug Resistance; Glutathione; Mice; Necrosis; Propidium; Reactive Oxygen Species; Skin Neoplasms; Sphingosine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2000
Ganglioside GD3, the mitochondrial permeability transition, and apoptosis.
    Annals of the New York Academy of Sciences, 1999, Volume: 893

    Topics: Animals; Apoptosis; Calcium; Cytochrome c Group; Gangliosides; Intracellular Membranes; Kinetics; Male; Mitochondria, Liver; Permeability; Rats; Rats, Inbred F344; Sphingosine

1999
Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells.
    Molecular and cellular neurosciences, 2000, Volume: 15, Issue:2

    Topics: Androstadienes; Animals; Cell Nucleus; Enzyme Activation; Kinetics; Mice; Nerve Growth Factor; PC12 Cells; Phosphoprotein Phosphatases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Recombinant Fusion Proteins; Sphingosine; Transfection; Wortmannin

2000
In vivo evidence that activation of tyrosine kinase is a trigger for lipopolysaccharide-induced fever in rats.
    Brain research, 2000, Jan-10, Volume: 852, Issue:2

    Topics: Animals; Antibodies; Body Temperature; Brain; Enzyme Inhibitors; Fever; Genistein; Injections, Intraventricular; Interleukin-1; Lipopolysaccharides; Male; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Rectum; Sphingosine; Tumor Necrosis Factor-alpha

2000
C2-Ceramide increases cytoplasmic calcium concentrations in human parathyroid cells.
    Biochemical and biophysical research communications, 2000, Feb-16, Volume: 268, Issue:2

    Topics: Calcium; Cytoplasm; Enzyme Inhibitors; Homeostasis; Humans; Microscopy, Confocal; Parathyroid Glands; Sphingosine; Tumor Cells, Cultured

2000
Regulation of rheumatoid synovial cell growth by ceramide.
    Biochemical and biophysical research communications, 2000, Mar-05, Volume: 269, Issue:1

    Topics: Apoptosis; Arthritis, Rheumatoid; Cell Division; Cells, Cultured; Enzyme Activation; Humans; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Platelet-Derived Growth Factor; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Sphingosine; Synovial Membrane

2000
Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation.
    Nature medicine, 2000, Volume: 6, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzoxazines; Brain Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cannabinoids; Ceramides; DNA-Binding Proteins; Dronabinol; Glioma; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Sphingomyelins; Sphingosine; Tumor Cells, Cultured

2000
Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis?
    Journal of neuroscience methods, 2000, Mar-15, Volume: 96, Issue:2

    Topics: Animals; Apoptosis; Cell Count; Cell Death; Cells, Cultured; Cerebral Cortex; Coloring Agents; Cycloheximide; Enzyme Inhibitors; Fetus; L-Lactate Dehydrogenase; Mice; Nerve Growth Factors; Neuroglia; Neurons; Neuroprotective Agents; Reproducibility of Results; Sphingosine; Tetrazolium Salts; Thiazoles; Trypan Blue

2000
Suppression of heat shock protein-70 by ceramide in heat shock-induced HL-60 cell apoptosis.
    The Journal of biological chemistry, 2000, Mar-24, Volume: 275, Issue:12

    Topics: Apoptosis; Ceramides; DNA-Binding Proteins; Gene Expression Regulation; Heat Shock Transcription Factors; Heat-Shock Response; HL-60 Cells; HSP70 Heat-Shock Proteins; Humans; Protein Biosynthesis; RNA Processing, Post-Transcriptional; Sphingosine; Transcription Factors; Transcription, Genetic

2000
Induction of apoptosis by all-trans-retinoic acid and C2-ceramide treatment in rat stromal-vascular cultures.
    Biochemical and biophysical research communications, 2000, Apr-02, Volume: 270, Issue:1

    Topics: Adipocytes; Adipose Tissue; Animals; Apoptosis; Inguinal Canal; Insulin; Rats; Rats, Sprague-Dawley; Sphingosine; Stem Cells; Stromal Cells; Tretinoin; Triiodothyronine

2000
Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells.
    Journal of neurochemistry, 2000, Volume: 74, Issue:4

    Topics: Apoptosis; Caspase 3; Caspases; Cell Division; Cell Membrane; Cell Survival; Chromones; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Morpholines; Neuroblastoma; Neurons; Palmitoyl Coenzyme A; Palmitoyl-CoA Hydrolase; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Sphingosine; Transfection; Tumor Cells, Cultured

2000
Ceramide path in human lung cell death.
    American journal of respiratory cell and molecular biology, 2000, Volume: 22, Issue:4

    Topics: Apoptosis; Ceramides; Diglycerides; DNA Fragmentation; Enzyme Activation; Epithelial Cells; Humans; Hydrogen Peroxide; Hydrolysis; Inflammation; Lung; Membrane Lipids; Oxidative Stress; Protein Kinase C; Second Messenger Systems; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Tetradecanoylphorbol Acetate

2000
Ceramide-induced cell death is independent of the Fas/Fas ligand pathway and is prevented by Nur77 overexpression in A20 B cells.
    Cell death and differentiation, 2000, Volume: 7, Issue:3

    Topics: Animals; Apoptosis; B-Lymphocytes; Caspase 1; Caspase 3; Caspases; Cell Cycle Proteins; Ceramides; Cyclin A; Cyclin E; Cyclin-Dependent Kinase Inhibitor p27; Cysteine Endopeptidases; DNA-Binding Proteins; Enzyme Activation; Fas Ligand Protein; fas Receptor; Gene Expression; Membrane Glycoproteins; Mice; Microtubule-Associated Proteins; Nuclear Receptor Subfamily 4, Group A, Member 1; Proto-Oncogene Proteins c-myc; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Retinoblastoma Protein; Sphingosine; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

2000
Ceramides that mediate apoptosis reduce glucose uptake and transporter affinity for glucose in human leukaemic cell lines but not in neutrophils.
    Pharmacology & toxicology, 2000, Volume: 86, Issue:3

    Topics: Apoptosis; Cell Division; Cell Survival; Ceramides; Deoxyglucose; Dose-Response Relationship, Drug; Formazans; Glucose; Humans; Jurkat Cells; Monosaccharide Transport Proteins; Neutrophils; Sphingomyelin Phosphodiesterase; Sphingosine; Tetrazolium Salts; Tumor Cells, Cultured; U937 Cells

2000
Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of l -cysteine.
    Journal of immunology (Baltimore, Md. : 1950), 2000, Apr-15, Volume: 164, Issue:8

    Topics: Animals; Cells, Cultured; Cerebral Cortex; Cysteine; Cytokines; Dose-Response Relationship, Immunologic; HIV Envelope Protein gp120; HIV-1; Humans; Immune Sera; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Macrophage Activation; Macrophages; Monocytes; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1; Receptors, N-Methyl-D-Aspartate; Sialoglycoproteins; Sphingosine; Tumor Necrosis Factor-alpha

2000
Nitric oxide inhibits the tumor necrosis factor alpha -regulated endocytosis of human dendritic cells in a cyclic GMP-dependent way.
    The Journal of biological chemistry, 2000, Jun-30, Volume: 275, Issue:26

    Topics: Animals; Blotting, Western; Brain; Cells, Cultured; Ceramides; Coculture Techniques; Cyclic GMP; Dendritic Cells; Down-Regulation; Endocytosis; Enzyme Inhibitors; Flow Cytometry; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-4; Leukocytes, Mononuclear; Lipopolysaccharides; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Sphingosine; Time Factors; Tumor Necrosis Factor-alpha

2000
Ceramide-induced cell death in cultured rat retinal pigment epithelial cells.
    The Tohoku journal of experimental medicine, 2000, Volume: 190, Issue:3

    Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase Inhibitors; Cell Survival; Cells, Cultured; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Pigment Epithelium of Eye; Rats; Rats, Long-Evans; Sphingosine

2000
Protective roles for ATM in cellular response to oxidative stress.
    FEBS letters, 2000, Apr-21, Volume: 472, Issue:1

    Topics: Animals; Antioxidants; Apoptosis; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Bleomycin; Catalase; Cell Cycle Proteins; Cell Line; Chickens; Chromosome Aberrations; Dexamethasone; DNA-Binding Proteins; Glutathione Peroxidase; Hydrogen Peroxide; Mutation; Oxidants; Oxidative Stress; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Sphingosine; Tumor Suppressor Proteins; X-Rays

2000
Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, May-09, Volume: 97, Issue:10

    Topics: Antigens, CD; Apoptosis; Caspase 8; Caspase 9; Caspases; Ceramides; Cyclic GMP; Enzyme Inhibitors; Humans; Kinetics; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Proteins; Quinoxalines; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; S-Nitroso-N-Acetylpenicillamine; Second Messenger Systems; Signal Transduction; Sphingosine; TNF Receptor-Associated Factor 1; Tumor Necrosis Factor-alpha; U937 Cells

2000
Tumor necrosis factor-alpha-induced apoptosis is associated with suppression of insulin-like growth factor binding protein-5 secretion in differentiating murine skeletal myoblasts.
    Journal of cellular physiology, 2000, Volume: 183, Issue:3

    Topics: Animals; Apoptosis; Cell Cycle; Cell Line; Creatine Kinase; Fibroblast Growth Factor 2; Humans; Insulin-Like Growth Factor Binding Protein 5; Insulin-Like Growth Factor II; Mice; Muscle, Skeletal; Recombinant Proteins; Second Messenger Systems; Sphingosine; Transfection; Tumor Necrosis Factor-alpha

2000
Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release.
    FEBS letters, 2000, May-04, Volume: 473, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Antibodies, Monoclonal; Apoptosis; Carrier Proteins; Caspase 3; Caspase 8; Caspase 9; Caspases; Cytochrome c Group; DNA Fragmentation; Drug Resistance, Neoplasm; Enzyme Activation; Fas Ligand Protein; fas Receptor; Fas-Associated Death Domain Protein; Gene Expression; Humans; Hydrolysis; Melanoma; Membrane Glycoproteins; Mitochondria; RNA, Messenger; Signal Transduction; Sphingomyelins; Sphingosine; Tumor Cells, Cultured

2000
Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells.
    Neuroscience letters, 2000, May-19, Volume: 285, Issue:3

    Topics: Apoptosis; Cell Survival; Enzyme Inhibitors; Flavonoids; Humans; Neuroblastoma; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Cells, Cultured

2000
Ceramide inhibits L-type calcium channel currents in rat pinealocytes.
    Advances in experimental medicine and biology, 1999, Volume: 460

    Topics: Animals; Calcium Channels, L-Type; Cells, Cultured; Cyclic AMP; Cyclic GMP; Isoproterenol; Male; Membrane Potentials; Patch-Clamp Techniques; Pineal Gland; Potassium Chloride; Rats; Rats, Sprague-Dawley; Sphingosine

1999
Ceramide-mediated stimulation of inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation in murine macrophages requires tyrosine kinase activity.
    Journal of leukocyte biology, 2000, Volume: 67, Issue:5

    Topics: Animals; Benzoquinones; Cell Line; Ceramides; Enzyme Induction; Enzyme Inhibitors; Genistein; Interferon-gamma; Lactams, Macrocyclic; Macrophage Activation; Macrophages; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Recombinant Proteins; Rifabutin; Sphingosine; Tumor Necrosis Factor-alpha

2000
Involvement of SAPK/JNK pathway in X-ray-induced rapid cell death of human T-cell leukemia cell line MOLT-4.
    Cancer letters, 2000, Jul-31, Volume: 155, Issue:2

    Topics: Animals; Blotting, Southern; Blotting, Western; Bridged-Ring Compounds; Cell Death; Cell Line; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Humans; Leukemia, T-Cell; Mice; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Norbornanes; Phosphodiesterase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Thiocarbamates; Thiones; Time Factors; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53; X-Rays

2000
Failure of gelsolin overexpression to regulate lymphocyte apoptosis.
    Blood, 2000, Jun-01, Volume: 95, Issue:11

    Topics: Apoptosis; Cell Division; Cell Line; Cytokines; Enzyme Inhibitors; fas Receptor; Gelsolin; Humans; Jurkat Cells; Kinetics; Recombinant Proteins; Sphingosine; T-Lymphocytes; Transfection

2000
The role of ceramide in the modulation of intracellular Ca2+ levels by interleukin 1 beta in rat cortical synaptosomes.
    Cytokine, 2000, Volume: 12, Issue:5

    Topics: Animals; Calcium; Ceramides; Cerebral Cortex; Interleukin-1; Intracellular Fluid; Male; Mitogen-Activated Protein Kinase 1; Rats; Rats, Wistar; Sphingosine; Synaptosomes

2000
Clustering of distinct autoimmune diseases associated with functional abnormalities of T cell survival in children.
    Clinical and experimental immunology, 2000, Volume: 121, Issue:1

    Topics: Adolescent; Apoptosis; Autoimmune Diseases; Cell Survival; Cells, Cultured; Diabetes Mellitus, Type 1; fas Receptor; Female; Humans; Immunophenotyping; Leukocytes, Mononuclear; Male; Sphingosine; T-Lymphocytes

2000
Lack of costimulation by both sphingomyelinase and C2 ceramide in resting human T cells.
    Immunology, 2000, Volume: 100, Issue:2

    Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; B7-1 Antigen; CD3 Complex; Cell Culture Techniques; Cell Division; Cell Survival; Enzyme Inhibitors; Humans; Jurkat Cells; Lectins, C-Type; Lymphocyte Activation; Receptors, Interleukin-2; Sphingomyelin Phosphodiesterase; Sphingosine; T-Lymphocytes; Up-Regulation

2000
Mechanisms by which short-chain ceramides cause apoptosis.
    Biochemical Society transactions, 1999, Volume: 27, Issue:4

    Topics: Acetates; Animals; Anticholesteremic Agents; Apoptosis; Cell Line; Ceramides; Cricetinae; Dose-Response Relationship, Drug; Fibroblasts; Kidney; Phosphatidylcholines; Sphingomyelins; Sphingosine

1999
Effect of dimethylsphingosine on muscarinic M(3) receptor signalling in SH-SY5Y cells.
    European journal of pharmacology, 2000, Aug-18, Volume: 402, Issue:1-2

    Topics: Brain Neoplasms; Calcium; Cell Line; Enzyme Inhibitors; GTP-Binding Proteins; Humans; Image Processing, Computer-Assisted; Inositol 1,4,5-Trisphosphate; Lysophospholipids; Methacholine Chloride; Muscarinic Agonists; N-Methylscopolamine; Neuroblastoma; Receptor, Muscarinic M3; Receptors, Muscarinic; Signal Transduction; Sphingosine

2000
Implication of sphingolipid metabolism in the stability of the Golgi apparatus.
    Journal of cell science, 2000, Volume: 113 ( Pt 18)

    Topics: Animals; Brefeldin A; Cattle; Cell Line; Ceramides; Coat Protein Complex I; Endocannabinoids; Endosomes; Enzyme Inhibitors; Ethanolamines; Golgi Apparatus; Masoprocol; Microscopy, Electron; Morpholines; Nocodazole; Oleic Acids; Sphingolipids; Sphingomyelin Phosphodiesterase; Sphingosine; trans-Golgi Network

2000
Ceramides induce apoptosis in HeLa cells and enhance cytochrome c-induced apoptosis in Xenopus egg extracts.
    Cellular and molecular life sciences : CMLS, 2000, Volume: 57, Issue:7

    Topics: Animals; Apoptosis; Caspase Inhibitors; Caspases; Cell Nucleus; Cell-Free System; Cytochrome c Group; DNA Fragmentation; HeLa Cells; Humans; Mice; Microscopy, Electron; Microscopy, Fluorescence; Mitochondria, Liver; Oocytes; Signal Transduction; Sphingosine; Xenopus

2000
Ceramide 2 (N-acetyl sphingosine) is associated with reduction in Bcl-2 protein levels by Western blotting and with apoptosis in cultured human keratinocytes.
    The British journal of dermatology, 2000, Volume: 143, Issue:3

    Topics: Apoptosis; Blotting, Western; Cell Count; Cell Division; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Down-Regulation; Flow Cytometry; Humans; In Situ Nick-End Labeling; Infant, Newborn; Keratinocytes; Proto-Oncogene Proteins c-bcl-2; Sphingosine

2000
Ceramide-induced TCR up-regulation.
    Journal of immunology (Baltimore, Md. : 1950), 2000, Sep-15, Volume: 165, Issue:6

    Topics: Amino Acid Motifs; Down-Regulation; Enzyme Activation; Exocytosis; Humans; Jurkat Cells; Kinetics; Leucine; Leukocytes, Mononuclear; Lymphocyte Activation; Membrane Proteins; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Protein Kinase C; Protein Phosphatase 2; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Antigen, T-Cell; Sphingosine; T-Lymphocytes; Up-Regulation

2000
Mitochondrial free calcium levels (Rhod-2 fluorescence) and ultrastructural alterations in neuronally differentiated PC12 cells during ceramide-dependent cell death.
    The Journal of comparative neurology, 2000, Oct-16, Volume: 426, Issue:2

    Topics: Animals; Calcimycin; Calcium; Cell Death; Cell Differentiation; Endoplasmic Reticulum; Fluorescence; Fluorescent Dyes; Heterocyclic Compounds, 3-Ring; Mitochondria; Neurons; PC12 Cells; Rats; Sphingosine; Time Factors

2000
The effect of a ceramide analog, N-acetylsphingosine on the induction of proliferation and IL-2 synthesis in T cells from young and old F344 rats.
    Immunopharmacology, 2000, Volume: 49, Issue:3

    Topics: Aging; Animals; Apoptosis; Cell Division; Growth Inhibitors; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Male; Rats; Rats, Inbred F344; Sphingosine; T-Lymphocytes

2000
Induction of tissue factor production but not the upregulation of adhesion molecule expression by ceramide in human vascular endothelial cells.
    The Tohoku journal of experimental medicine, 2000, Volume: 191, Issue:3

    Topics: Antigens, CD; Apoptosis; Cell Line; Endothelium, Vascular; HL-60 Cells; Humans; Intercellular Adhesion Molecule-1; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Necrosis Factor-alpha; U937 Cells; Up-Regulation; Vascular Cell Adhesion Molecule-1

2000
Bcl-2 transfected HaCaT keratinocytes resist apoptotic signals of ceramides, tumor necrosis factor alpha and 1 alpha, 25-dihydroxyvitamin D(3).
    Archives of dermatological research, 2000, Volume: 292, Issue:9

    Topics: Apoptosis; Calcitriol; Cell Line; DNA Fragmentation; Dose-Response Relationship, Drug; Gene Expression Regulation; Genes, bcl-2; Genetic Vectors; Humans; Keratinocytes; Phosphatidylserines; Sphingosine; Transfection; Tumor Necrosis Factor-alpha

2000
Sphingolipids and cholesterol modulate membrane susceptibility to cytosolic phospholipase A(2).
    Journal of lipid research, 2000, Volume: 41, Issue:10

    Topics: Animals; Calcimycin; Ceramides; CHO Cells; Cholesterol; Cricetinae; Cytosol; Enzyme Activation; Enzyme Inhibitors; Epinephrine; Fatty Acids; Humans; Ionophores; Lipid Bilayers; Liposomes; Membrane Lipids; Phospholipases A; Phospholipids; Rats; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Sphingolipids; Sphingosine

2000
The lipids C2- and C16-ceramide form large stable channels. Implications for apoptosis.
    The Journal of biological chemistry, 2000, Dec-08, Volume: 275, Issue:49

    Topics: Apoptosis; Ceramides; Cholesterol; Electric Conductivity; Electrochemistry; Ion Channels; Liposomes; Models, Biological; Models, Molecular; Molecular Conformation; Phosphatidylcholines; Phospholipids; Sphingosine; Structure-Activity Relationship

2000
Ceramide-induced apoptosis of human thyroid cancer cells resistant to apoptosis by irradiation.
    Thyroid : official journal of the American Thyroid Association, 2000, Volume: 10, Issue:9

    Topics: Apoptosis; Blood; Colforsin; Cyclic AMP-Dependent Protein Kinases; Diglycerides; Enzyme Activation; Gamma Rays; Humans; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Phorbol Esters; Protein Kinase C; Second Messenger Systems; Signal Transduction; Sphingosine; Thyroid Neoplasms; Tumor Cells, Cultured

2000
Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide.
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2000, Volume: 10, Issue:5

    Topics: Adipocytes; Adipose Tissue, Brown; Animals; Apoptosis; Cattle; Cell Line, Transformed; Ceramides; Enzyme Inhibitors; Insulin; Mice; Moloney murine leukemia virus; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Ribosomal Protein S6 Kinases; Sphingosine; Transfection

2000
Inhibition of phosphatidylcholine synthesis precedes apoptosis induced by C2-ceramide: protection by exogenous phosphatidylcholine.
    Neuroreport, 2000, Sep-28, Volume: 11, Issue:14

    Topics: Animals; Animals, Newborn; Apoptosis; Cell Membrane; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Neurons; Neuroprotective Agents; Phosphatidylcholines; Rats; Rats, Wistar; Signal Transduction; Sphingosine

2000
Akt regulates cell survival and apoptosis at a postmitochondrial level.
    The Journal of cell biology, 2000, Oct-30, Volume: 151, Issue:3

    Topics: Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Caspase 3; Caspase 9; Caspases; Cell Extracts; Cell Line; Cell Survival; Cell-Free System; Cytochrome c Group; Enzyme Activation; Humans; Hybrid Cells; Microinjections; Mitochondria; Motor Neurons; Phosphatidylinositol 3-Kinases; Poly(ADP-ribose) Polymerases; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Sphingosine

2000
Regulation of phospholipase D activity and ceramide production in daunorubicin-induced apoptosis in A-431 cells.
    Biochimica et biophysica acta, 2000, Nov-15, Volume: 1488, Issue:3

    Topics: Apoptosis; Ceramides; Daunorubicin; Diglycerides; Enzyme Activation; Humans; Phospholipase D; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Cells, Cultured

2000
Filopodial behavior is dependent on the phosphorylation state of neuronal growth cones.
    Cell motility and the cytoskeleton, 2000, Volume: 47, Issue:4

    Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Carrier Proteins; Cells, Cultured; Cerebrosides; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Genistein; Growth Cones; Indole Alkaloids; Intracellular Signaling Peptides and Proteins; Models, Biological; Myosin-Light-Chain Kinase; Naphthalenes; Neurons; Okadaic Acid; Phosphorylation; Protein Kinase C; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Pseudopodia; Signal Transduction; Snails; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors; Vanadates

2000
Release of plasminogen activator inhibitor-1 from human astrocytes is regulated by intracellular ceramide.
    Journal of neuroscience research, 2000, Dec-15, Volume: 62, Issue:6

    Topics: Animals; Antibiotics, Antineoplastic; Astrocytes; Cell Death; Ceramides; Culture Media, Conditioned; Daunorubicin; Enzyme Inhibitors; Humans; Neurons; PC12 Cells; Plasminogen Activator Inhibitor 1; Rats; Sphingosine; Tissue Plasminogen Activator; Tumor Necrosis Factor-alpha

2000
C2-ceramide induces apoptosis in a human squamous cell carcinoma cell line.
    The British journal of dermatology, 2000, Volume: 143, Issue:6

    Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Size; Cell Survival; Ceramides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; In Situ Nick-End Labeling; Microscopy, Electron; Skin Neoplasms; Sphingosine; Tumor Cells, Cultured

2000
The protective effect of ceramide in immature rat brain hypoxia-ischemia involves up-regulation of bcl-2 and reduction of TUNEL-positive cells.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2001, Volume: 21, Issue:1

    Topics: Animals; Apoptosis; Brain; Disease Models, Animal; Gene Expression Regulation; Genes, bcl-2; Hypoxia-Ischemia, Brain; In Situ Nick-End Labeling; Infusions, Parenteral; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingosine; Stereotaxic Techniques; Tumor Necrosis Factor-alpha

2001
Ceramide does not inhibit protein kinase C beta-dependent phospholipase D activity stimulated by anti-Fas monoclonal antibody in A20 cells.
    Cellular signalling, 2000, Volume: 12, Issue:11-12

    Topics: Animals; Antibodies, Monoclonal; Bridged-Ring Compounds; Cell Membrane; Ceramides; Cytosol; Diglycerides; Enzyme Activation; fas Receptor; Isoenzymes; Mice; Norbornanes; Phospholipase D; Protein Kinase C; Protein Kinase C beta; Protein Transport; Receptor Aggregation; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Thiocarbamates; Thiones; Tumor Cells, Cultured; Type C Phospholipases

2000
t-SNARE dephosphorylation promotes SNARE assembly and exocytosis in yeast.
    The EMBO journal, 2001, Feb-01, Volume: 20, Issue:3

    Topics: Exocytosis; Fungal Proteins; Membrane Fusion; Membrane Proteins; Models, Biological; Mutagenesis, Site-Directed; Mutation; Phosphoprotein Phosphatases; Phosphorylation; Qa-SNARE Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; SNARE Proteins; Sphingosine; Temperature; Vesicular Transport Proteins

2001
C2-ceramide and reactive oxygen species inhibit pituitary adenylate cyclase activating polypeptide (PACAP)-induced cyclic-AMP-dependent signalling pathway.
    Journal of neurochemistry, 2001, Volume: 76, Issue:3

    Topics: Adenylyl Cyclases; Cell Line; Cyclic AMP; GTP-Binding Proteins; Neuropeptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Tyrosine Phosphatases; Reactive Oxygen Species; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; Receptors, Pituitary Hormone; Signal Transduction; Sphingosine

2001
Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells.
    Biochemical and biophysical research communications, 2001, Feb-02, Volume: 280, Issue:4

    Topics: Androstadienes; Blotting, Western; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Serine; Sphingosine; Threonine; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins; Wortmannin

2001
T-cell receptor downregulation by ceramide-induced caspase activation and cleavage of the zeta chain.
    Scandinavian journal of immunology, 2001, Volume: 53, Issue:2

    Topics: Amino Acid Chloromethyl Ketones; Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Apoptosis; Binding Sites; Caspases; Cysteine Proteinase Inhibitors; Down-Regulation; Enzyme Activation; Humans; Jurkat Cells; Membrane Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligopeptides; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Receptors, Antigen, T-Cell, gamma-delta; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Sphingosine; Transfection

2001
Cell cycle arrest of hematopoietic cell lines after treatment with ceramide is commonly associated with retinoblastoma activation.
    Cytometry, 2001, Mar-01, Volume: 43, Issue:3

    Topics: Cell Cycle; Enzyme Inhibitors; Flow Cytometry; G1 Phase; Hematopoietic Stem Cells; HL-60 Cells; Humans; Jurkat Cells; Leukemia; Phosphorylation; Resting Phase, Cell Cycle; Retinoblastoma Protein; Sphingosine; Tumor Cells, Cultured; U937 Cells

2001
Ceramide dissociates 3'-phosphoinositide production from pleckstrin homology domain translocation.
    The Biochemical journal, 2001, Mar-01, Volume: 354, Issue:Pt 2

    Topics: 3T3 Cells; Animals; Blood Proteins; Ceramides; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Glucose Transporter Type 4; Isoenzymes; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phospholipase C delta; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sequence Homology, Amino Acid; Sphingolipids; Sphingosine; Structure-Activity Relationship; Type C Phospholipases

2001
Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IkappaB kinase 1/2 in human alveolar epithelial cells.
    Molecular pharmacology, 2001, Volume: 59, Issue:3

    Topics: Cell Nucleus; Ceramides; Cyclooxygenase 2; Drug Interactions; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Epithelium; Flavonoids; Humans; I-kappa B Kinase; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Membrane Proteins; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Mutation; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Pulmonary Alveoli; Pyridines; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2001
NF-kappa B mediates the adaptation of human U937 cells to hydrogen peroxide.
    Free radical biology & medicine, 2001, Mar-01, Volume: 30, Issue:5

    Topics: Adaptation, Physiological; DNA Fragmentation; Humans; Hydrogen Peroxide; I-kappa B Kinase; NF-kappa B; Oxidative Stress; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Sphingosine; U937 Cells

2001
Hepatocyte growth factor protects gastric epithelial cells against ceramide-induced apoptosis through induction of cyclooxygenase-2.
    Life sciences, 2000, Dec-22, Volume: 68, Issue:5

    Topics: Animals; Apoptosis; Cell Line; Cell Survival; Ceramides; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Induction; Gastric Mucosa; Hepatocyte Growth Factor; Humans; In Situ Nick-End Labeling; Isoenzymes; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Sulfonamides; Transcription, Genetic

2000
Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.
    Cancer research, 2001, Feb-01, Volume: 61, Issue:3

    Topics: Amides; Amidohydrolases; Animals; Apoptosis; Ceramidases; Ceramides; Colonic Neoplasms; Enzyme Inhibitors; Growth Inhibitors; Humans; Liver; Liver Neoplasms, Experimental; Male; Mice; Myristates; Propanolamines; Rats; Rats, Wistar; Sphingosine; Xenograft Model Antitumor Assays

2001
Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells.
    Journal of neurochemistry, 2001, Volume: 76, Issue:5

    Topics: Adrenal Gland Neoplasms; Animals; Apoptosis; Caspase 2; Caspase 3; Caspase 7; Caspases; Culture Media, Serum-Free; JNK Mitogen-Activated Protein Kinases; Kinetics; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nerve Growth Factor; PC12 Cells; Pertussis Toxin; Pheochromocytoma; Phosphotransferases (Alcohol Group Acceptor); Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Recombinant Proteins; Sphingosine; Transfection; Virulence Factors, Bordetella

2001
Subtype-specific translocation of the delta subtype of protein kinase C and its activation by tyrosine phosphorylation induced by ceramide in HeLa cells.
    Molecular and cellular biology, 2001, Volume: 21, Issue:5

    Topics: Adenoviridae; Animals; Antineoplastic Agents; Cell Fractionation; Cell Line; Cell Membrane; Ceramides; CHO Cells; Cricetinae; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Golgi Apparatus; Green Fluorescent Proteins; HeLa Cells; Humans; Immunoblotting; Interferon-gamma; Isoenzymes; Luminescent Proteins; Magnesium; Phorbol Esters; Phosphatidylserines; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Transport; Recombinant Fusion Proteins; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Time Factors; Tyrosine

2001
Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors.
    International journal of cancer, 2001, Feb-20, Volume: 96, Issue:1

    Topics: Antigens, Differentiation; Apoptosis; CCAAT-Enhancer-Binding Proteins; Cell Cycle Proteins; Cell Division; Cell Nucleus; Ceramides; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Fragmentation; Enzyme Inhibitors; fas Receptor; Fluorescent Dyes; GADD45 Proteins; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Phenotype; Plasmids; Protein Phosphatase 1; Proteins; Proto-Oncogene Proteins c-bcl-2; Radiation, Ionizing; Serpins; Signal Transduction; Sphingosine; Time Factors; Transcription Factor CHOP; Transcription Factors; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; U937 Cells; Up-Regulation; Viral Proteins

2001
Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.
    Diabetologia, 2001, Volume: 44, Issue:2

    Topics: Biological Transport; Cell Line; Cell Membrane; Enzyme Activation; Glucose; Glycogen; Inositol Phosphates; Insulin; Insulin Receptor Substrate Proteins; Muscle, Skeletal; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Sphingosine

2001
Short-chain ceramide regulates hepatic methionine adenosyltransferase expression.
    Journal of hepatology, 2001, Volume: 34, Issue:2

    Topics: Animals; Cells, Cultured; Gene Expression Regulation, Enzymologic; Hepatocytes; Interleukin-6; Isoenzymes; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Methionine; Methionine Adenosyltransferase; Rats; RNA, Messenger; Sphingosine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2001
Loss of cyclin A and G1-cell cycle arrest are a prerequisite of ceramide-induced toxicity in human arterial endothelial cells.
    Cardiovascular research, 2001, Volume: 50, Issue:1

    Topics: Apoptosis; Arteries; Cell Count; Cell Culture Techniques; Cell Division; Cyclin A; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; G1 Phase; Humans; Phosphoprotein Phosphatases; Sphingosine

2001
Involvement of sphingomyelinase in insulin-induced phosphatidylinositol 3-kinase activation.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:6

    Topics: Animals; Cells, Cultured; Drug Interactions; Enzyme Activation; Enzyme Induction; Epidermis; Hexachlorocyclohexane; Insulin; Mice; Phosphatidylinositol 3-Kinases; Platelet Aggregation Inhibitors; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Cells, Cultured

2001
Cell permeable exogenous ceramide reduces infarct size in spontaneously hypertensive rats supporting in vitro studies that have implicated ceramide in induction of tolerance to ischemia.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2001, Volume: 21, Issue:3

    Topics: Animals; Brain Ischemia; Cell Membrane Permeability; Ceramides; In Vitro Techniques; Infarction, Middle Cerebral Artery; Injections, Intravenous; Injections, Intraventricular; Ischemic Preconditioning; Lipopolysaccharides; Male; Rats; Rats, Inbred SHR; Sphingosine; Tumor Necrosis Factor-alpha

2001
Ceramide inhibits cell proliferation through Akt/PKB inactivation and decreases melanin synthesis in Mel-Ab cells.
    Pigment cell research, 2001, Volume: 14, Issue:2

    Topics: Animals; Cell Division; Cell Line; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Humans; Melanins; Melanocytes; Melanoma; Mice; Mitogen-Activated Protein Kinases; Monophenol Monooxygenase; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sphingosine

2001
Ceramide inhibits lipopolysaccharide-mediated nitric oxide synthase and cyclooxygenase-2 induction in macrophages: effects on protein kinases and transcription factors.
    Journal of immunology (Baltimore, Md. : 1950), 2001, May-01, Volume: 166, Issue:9

    Topics: Active Transport, Cell Nucleus; Animals; Biological Transport; Cell Line; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; I-kappa B Kinase; I-kappa B Proteins; Immunosuppressive Agents; Isoenzymes; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Serine-Threonine Kinases; Sphingosine; Transcription Factor AP-1; Transcription Factor RelA; Transcription Factors

2001
Ceramide reduces endothelium-dependent vasodilation by increasing superoxide production in small bovine coronary arteries.
    Circulation research, 2001, Apr-27, Volume: 88, Issue:8

    Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Animals; Arteries; Bradykinin; Calcimycin; Cattle; Ceramides; Citrulline; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Fluorescent Dyes; Free Radical Scavengers; In Vitro Techniques; Intracellular Fluid; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Sphingosine; Superoxide Dismutase; Superoxides; Vasodilation

2001
Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells.
    The EMBO journal, 2001, May-15, Volume: 20, Issue:10

    Topics: Actins; Animals; Catalysis; Cattle; Cells, Cultured; Chromaffin Cells; Enzyme Inhibitors; Exocytosis; Intracellular Fluid; Isoenzymes; Neurosecretory Systems; PC12 Cells; Phosphatidylinositol 4,5-Diphosphate; Phospholipase D; Protein Kinase C; Rats; Sphingosine

2001
Effects of ceramide on aggrecanase activity in rabbit articular cartilage.
    Biochemical and biophysical research communications, 2001, May-25, Volume: 283, Issue:5

    Topics: Aggrecans; Animals; Cartilage, Articular; Endopeptidases; Epitopes; Extracellular Matrix Proteins; Hexosamines; Interleukin-1; Kinetics; Lectins, C-Type; Male; Peptide Fragments; Proteoglycans; Rabbits; Sphingosine

2001
Caspase-resistant vimentin suppresses apoptosis after photodynamic treatment with a silicon phthalocyanine in Jurkat cells.
    Archives of biochemistry and biophysics, 2001, Jun-01, Volume: 390, Issue:1

    Topics: Apoptosis; Caspases; Drug Resistance; Humans; Indoles; Jurkat Cells; Organosilicon Compounds; Oxidative Stress; Photochemotherapy; Photosensitizing Agents; Poly(ADP-ribose) Polymerases; Silanes; Sphingosine; Transfection; Vimentin

2001
Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases.
    Brain research, 2001, Jun-08, Volume: 903, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Enkephalins; Enzyme Inhibitors; Flavonoids; Gene Expression; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Protein Precursors; Protein Synthesis Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Stimulation, Chemical; Sulfonamides; Transcription Factor AP-1

2001
The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action.
    The EMBO journal, 2001, Jun-01, Volume: 20, Issue:11

    Topics: Aequorin; Apoptosis; Calcium; Calcium-Binding Proteins; Calcium-Transporting ATPases; Calreticulin; Caspase 3; Caspases; Endoplasmic Reticulum; Enzyme Inhibitors; Genes, bcl-2; Genes, Reporter; Green Fluorescent Proteins; HeLa Cells; Humans; Kinetics; Luminescent Proteins; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Ribonucleoproteins; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sphingosine; Transfection

2001
Angiostatin effects on endothelial cells mediated by ceramide and RhoA.
    EMBO reports, 2001, Volume: 2, Issue:6

    Topics: Angiostatins; Cell Membrane; Cells, Cultured; Cytoskeleton; Dose-Response Relationship, Drug; Endothelium, Vascular; Homeodomain Proteins; Humans; Immunoblotting; Kinetics; LIM-Homeodomain Proteins; Microscopy, Phase-Contrast; Nerve Tissue Proteins; Oligonucleotide Array Sequence Analysis; Peptide Fragments; Plasminogen; Protein Transport; rhoA GTP-Binding Protein; Signal Transduction; Sphingosine; Time Factors; Transcription Factors; Umbilical Veins

2001
Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation.
    The European journal of neuroscience, 2001, Volume: 13, Issue:11

    Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Ceramides; Cerebral Cortex; Down-Regulation; Enzyme Inhibitors; Fetus; Imidazoles; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyridines; RNA; Sphingomyelins; Sphingosine; Tumor Suppressor Protein p53; Up-Regulation

2001
Uncoupling protein-3 mRNA up-regulation in C2C12 myotubes after etomoxir treatment.
    Biochimica et biophysica acta, 2001, Jun-29, Volume: 1532, Issue:3

    Topics: Animals; Carnitine O-Palmitoyltransferase; Carrier Proteins; Cell Line; Ceramides; Enzyme Inhibitors; Epoxy Compounds; Ion Channels; Mice; Mitochondrial Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Uncoupling Protein 3; Up-Regulation

2001
Propagation of the apoptotic signal by mitochondrial waves.
    The EMBO journal, 2001, Aug-01, Volume: 20, Issue:15

    Topics: Animals; Apoptosis; Calcium; Caspases; Cell Line; Cell Membrane Permeability; Cytochrome c Group; Enzyme Activation; Enzyme Inhibitors; Ethanol; Mitochondria, Heart; Rats; Sarcoplasmic Reticulum; Signal Transduction; Sphingosine

2001
Ceramide blocks PDGF-induced DNA synthesis in mesangial cells via inhibition of Akt kinase in the absence of apoptosis.
    Biochemical and biophysical research communications, 2001, Sep-07, Volume: 286, Issue:5

    Topics: Animals; Apoptosis; Arabidopsis Proteins; Cell Division; Ceramides; DNA; Dose-Response Relationship, Drug; Glomerular Mesangium; Hydrogen Peroxide; Kinetics; Luciferases; Phosphatidylinositol 3-Kinases; Plant Proteins; Platelet-Derived Growth Factor; Potassium Channel Blockers; Potassium Channels; Precipitin Tests; Protein Binding; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingosine; Time Factors; Transfection

2001
C2-ceramide signaling in glioma cells: synergistic enhancement of CD95-mediated, caspase-dependent apoptosis.
    Cell death and differentiation, 2001, Volume: 8, Issue:6

    Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase Inhibitors; Caspases; Cytochrome c Group; Drug Synergism; Enzyme Activation; Fas Ligand Protein; fas Receptor; Humans; Immunoblotting; Membrane Glycoproteins; Microscopy, Electron; Mitochondria; Neuroglia; Poly(ADP-ribose) Polymerases; Signal Transduction; Sphingosine; Tumor Cells, Cultured

2001
Ceramide inhibition of mammalian phospholipase D1 and D2 activities is antagonized by phosphatidylinositol 4,5-bisphosphate.
    Biochemistry, 2001, Sep-18, Volume: 40, Issue:37

    Topics: Bacterial Proteins; Catalytic Domain; Ceramides; Drug Interactions; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Isoenzymes; Liposomes; Phosphatidylinositol 4,5-Diphosphate; Phospholipase D; Plant Proteins; Protein Binding; Sphingosine

2001
Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids.
    Cancer research, 2001, Sep-15, Volume: 61, Issue:18

    Topics: Adenomatous Polyposis Coli Protein; Animals; beta Catenin; Cattle; Cell Division; Cell Nucleus; Colonic Neoplasms; Cytoskeletal Proteins; Cytosol; Diet; Humans; Intestinal Mucosa; Intestinal Neoplasms; Male; Mice; Mice, Inbred C57BL; Signal Transduction; Sphingolipids; Sphingosine; Trans-Activators; Tumor Cells, Cultured

2001
Sphingomyelinase but not ceramide induces nitric oxide synthase expression in rat brain microglia.
    Neuroscience letters, 2001, Sep-28, Volume: 311, Issue:2

    Topics: Amyloid beta-Peptides; Animals; Carboxylic Acids; Cells, Cultured; Enzyme Inhibitors; Fumonisins; Gene Expression Regulation, Enzymologic; Lipopolysaccharides; Microglia; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peptide Fragments; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingomyelin Phosphodiesterase; Sphingosine

2001
Role of palmitoyl-protein thioesterase in cell death: implications for infantile neuronal ceroid lipofuscinosis.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2001, Volume: 5 Suppl A

    Topics: Antibiotics, Antineoplastic; Apoptosis; Chromones; Daunorubicin; Enzyme Inhibitors; Etoposide; Humans; Infant; Morpholines; Nerve Degeneration; Neuroblastoma; Neuronal Ceroid-Lipofuscinoses; Neurons; Nucleic Acid Synthesis Inhibitors; Sphingosine; Staurosporine; Thiolester Hydrolases; Transfection; Tumor Cells, Cultured

2001
TNFalpha enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation.
    Experimental cell research, 2001, Oct-15, Volume: 270, Issue:1

    Topics: Antimycin A; Calcium; Ceramides; DNA Damage; DNA, Single-Stranded; Electron Transport; Electron Transport Complex III; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Mitochondria; Sphingosine; Superoxides; tert-Butylhydroperoxide; Tumor Necrosis Factor-alpha; U937 Cells

2001
Tumor necrosis factor-alpha induces stress fiber formation through ceramide production: role of sphingosine kinase.
    Molecular biology of the cell, 2001, Volume: 12, Issue:11

    Topics: Animals; cdc42 GTP-Binding Protein; Cell Line; Cytoskeletal Proteins; Cytoskeleton; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Paxillin; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein-Tyrosine Kinases; rac GTP-Binding Proteins; ras Proteins; Rats; rhoA GTP-Binding Protein; Sphingomyelin Phosphodiesterase; Sphingosine; Stress Fibers; Tumor Necrosis Factor-alpha; Tyrosine

2001
The IL-15R alpha chain signals through association with Syk in human B cells.
    Journal of immunology (Baltimore, Md. : 1950), 2001, Dec-01, Volume: 167, Issue:11

    Topics: Apoptosis; B-Lymphocyte Subsets; Calcium; Calcium Signaling; Cell Division; Enzyme Activation; Enzyme Precursors; Humans; Interleukin-15; Intracellular Signaling Peptides and Proteins; Isoenzymes; Jurkat Cells; K562 Cells; Lymphocyte Activation; Mutagenesis, Site-Directed; Oligonucleotides, Antisense; Phospholipase C gamma; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Interleukin-15; Receptors, Interleukin-2; Signal Transduction; Sphingosine; src Homology Domains; Syk Kinase; T-Lymphocyte Subsets; Tumor Cells, Cultured; Type C Phospholipases

2001
Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest.
    The Journal of biological chemistry, 2002, Feb-01, Volume: 277, Issue:5

    Topics: Animals; Aorta, Thoracic; Becaplermin; Cell Division; Cells, Cultured; Ceramides; Embryo, Mammalian; Humans; Insulin-Like Growth Factor I; Kinetics; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Rats; Recombinant Proteins; Sphingosine; Transfection

2002
Adaptive concentrations of hydrogen peroxide suppress cell death by blocking the activation of SAPK/JNK pathway.
    Journal of cell science, 2001, Volume: 114, Issue:Pt 23

    Topics: Adaptation, Physiological; Apoptosis; Enzyme Activation; Humans; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Kinase 7; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Oxidants; Signal Transduction; Sphingosine; Time Factors; U937 Cells

2001
Ceramide and glucosamine antagonism of alternate signaling pathways regulating insulin- and osmotic shock-induced glucose transporter 4 translocation.
    Endocrinology, 2002, Volume: 143, Issue:1

    Topics: 3T3 Cells; Animals; Biological Transport; Enzyme Inhibitors; Glucosamine; Glucose Transporter Type 4; Hexosamines; Insulin; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Osmotic Pressure; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Receptor, Insulin; Signal Transduction; Sphingosine; Viral Proteins

2002
Synergistic effect of interleukin-1alpha and ceramide analogue on production of prostaglandin E2 and F2alpha by endometrial stromal cells.
    American journal of reproductive immunology (New York, N.Y. : 1989), 2001, Volume: 46, Issue:6

    Topics: Cells, Cultured; Ceramides; Dinoprost; Dinoprostone; Drug Synergism; Endometrium; Female; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sialoglycoproteins; Sphingosine; Stromal Cells

2001
Ceramide does not act as a general second messenger for ultraviolet-induced apoptosis.
    Oncogene, 2002, Jan-03, Volume: 21, Issue:1

    Topics: Adenovirus E1A Proteins; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Breast Neoplasms; Caspase 1; Caspase 3; Caspase Inhibitors; Caspases; Ceramides; Enzyme Inhibitors; Female; Humans; Melanoma, Experimental; Mice; Protein Structure, Tertiary; Radiation Tolerance; Recombinant Fusion Proteins; Second Messenger Systems; Sphingosine; Transfection; Tumor Cells, Cultured; Ultraviolet Rays

2002
Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells.
    Neurochemistry international, 2002, Volume: 40, Issue:4

    Topics: Animals; Apoptosis; Calcium; Caspase 3; Caspases; Cells, Cultured; Ceramides; Culture Media, Serum-Free; Cytochrome c Group; Hippocampus; Membrane Potentials; Microscopy, Confocal; Mitochondria; Nerve Tissue Proteins; Neurons; Sphingosine

2002
Increased reactive oxygen species production down-regulates peroxisome proliferator-activated alpha pathway in C2C12 skeletal muscle cells.
    The Journal of biological chemistry, 2002, Mar-22, Volume: 277, Issue:12

    Topics: Animals; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Epoxy Compounds; Fatty Acids; Flavonoids; Flow Cytometry; Mice; Muscle, Skeletal; NF-kappa B; Polymerase Chain Reaction; Protein Binding; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; RNA; RNA, Messenger; Sphingosine; Thiocarbamates; Time Factors; Transcription Factors; Triazenes

2002
Membrane restructuring via ceramide results in enhanced solute efflux.
    The Journal of biological chemistry, 2002, Apr-05, Volume: 277, Issue:14

    Topics: Bacillus cereus; Biochemical Phenomena; Biochemistry; Cell Membrane; Ceramides; Cholesterol; Lipid Bilayers; Lipids; Protein Structure, Tertiary; Signal Transduction; Spectrophotometry; Sphingosine; Time Factors

2002
Cell-permeable ceramides preferentially inhibit coated vesicle formation and exocytosis in Chinese hamster ovary compared with Madin-Darby canine kidney cells by preventing the membrane association of ADP-ribosylation factor.
    The Biochemical journal, 2002, Feb-01, Volume: 361, Issue:Pt 3

    Topics: ADP-Ribosylation Factors; Animals; Capsid; Cell Line; Cell Membrane; CHO Cells; Cricetinae; Cytosol; Dogs; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Exocytosis; Golgi Apparatus; Immunoblotting; Phospholipase D; Protein Binding; Protein Kinase C; Rubella virus; Sphingosine; Time Factors

2002
Transient relaxation of rat mesenteric microvessels by ceramides.
    British journal of pharmacology, 2002, Volume: 135, Issue:2

    Topics: Animals; Ceramides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Mesentery; Microcirculation; Potassium Channel Blockers; Rats; Rats, Wistar; Sphingosine; Splanchnic Circulation; Vasodilation; Vasodilator Agents

2002
Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D.
    Blood, 2002, Feb-15, Volume: 99, Issue:4

    Topics: Cell Degranulation; Dose-Response Relationship, Drug; Humans; Lysophosphatidylcholines; Neutrophil Activation; Neutrophils; Oxidants; Phospholipase D; Phosphorylation; Protein Transport; Secretory Vesicles; Sphingosine; Superoxides

2002
Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA.
    Oncogene, 2002, Jan-31, Volume: 21, Issue:6

    Topics: Alkylation; Antineoplastic Agents, Alkylating; Apoptosis; bcl-2-Associated X Protein; Brain Neoplasms; DNA Damage; DNA, Neoplasm; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Genes, p53; Glioblastoma; Humans; Hydrogen Peroxide; Intercellular Signaling Peptides and Proteins; Neoplasm Proteins; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Sphingosine; Telomere; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ultraviolet Rays; Wnt Proteins; Zebrafish Proteins

2002
Vesnarinone causes oxidative damage by inhibiting catalase function through ceramide action in myeloid cell apoptosis.
    Molecular pharmacology, 2002, Volume: 61, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Catalase; Cell Division; Ceramides; Drug Synergism; Enzyme Inhibitors; HL-60 Cells; Humans; Lipid Peroxidation; Oxidative Stress; Pyrazines; Quinolines; Sphingosine

2002
C(2)-ceramide influences the expression and insulin-mediated regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 adipocytes.
    Diabetes, 2002, Volume: 51, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3T3 Cells; Adipocytes; Animals; Blotting, Western; Chromans; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Drug Interactions; Enzyme Inhibitors; Insulin; Insulin Resistance; Isoquinolines; Lipolysis; Mice; Receptors, Cytoplasmic and Nuclear; Sphingosine; Sulfonamides; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha

2002
Ceramide and sphingosine rapidly induce apoptosis of murine mast cells supported by interleukin-3 and stem cell factor.
    Experimental hematology, 2002, Volume: 30, Issue:3

    Topics: Animals; Apoptosis; Bone Marrow Cells; Carboxylic Acids; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Fumonisins; Interleukin-3; Male; Mast Cells; Mice; Mice, Inbred C57BL; Recombinant Proteins; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Stem Cell Factor

2002
Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A.
    Cellular signalling, 2002, Volume: 14, Issue:6

    Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Lithium; Neuroprotective Agents; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Sphingosine

2002
Tumor necrosis factor-alpha, sphingomyelinase and ceramides activate tyrosine kinase, p21Ras and phosphatidylinositol 3-kinase: implications for glucose transport and insulin resistance.
    Advances in experimental medicine and biology, 2001, Volume: 498

    Topics: Animals; Biological Transport; Ceramides; Enzyme Activation; Fibroblasts; Glucose; Insulin Resistance; Kinetics; Phosphatidylinositol 3-Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Rats; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Necrosis Factor-alpha

2001
Heat shock and ceramide have different apoptotic pathways in radiation induced fibrosarcoma (RIF) cells.
    Molecular and cellular biochemistry, 2002, Volume: 229, Issue:1-2

    Topics: Apoptosis; Cell Membrane; Fibrosarcoma; Heat-Shock Proteins; Heat-Shock Response; Kinetics; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Neoplasms, Radiation-Induced; Protein Biosynthesis; Proteins; Signal Transduction; Sphingosine

2002
Involvement of phosphatidylinositol 3-kinase in nuclear translocation of protein kinase C zeta induced by C2-ceramide in rat hepatocytes.
    FEBS letters, 2002, Mar-13, Volume: 514, Issue:2-3

    Topics: Active Transport, Cell Nucleus; Androstadienes; Animals; Cell Membrane; Cell Nucleus; Cell Separation; Chromones; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hepatocytes; Isoenzymes; Male; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Rats; Rats, Wistar; Sphingosine; Subcellular Fractions; Wortmannin

2002
HSP27 phosphorylation and interaction with actin-myosin in smooth muscle contraction.
    American journal of physiology. Gastrointestinal and liver physiology, 2002, Volume: 282, Issue:5

    Topics: Actins; Animals; Colon; Enzyme Inhibitors; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Myosins; Naphthalenes; Neoplasm Proteins; Phosphorylation; Precipitin Tests; Protein Kinase C; Rabbits; Sphingosine; Tropomyosin

2002
Sphingoid bases and ceramide induce apoptosis in HT-29 and HCT-116 human colon cancer cells.
    Experimental biology and medicine (Maywood, N.J.), 2002, Volume: 227, Issue:5

    Topics: Apoptosis; Cell Cycle; Cell Division; Ceramides; Colonic Neoplasms; DNA Fragmentation; Dose-Response Relationship, Drug; Flow Cytometry; HT29 Cells; Humans; Microscopy, Fluorescence; Sphingosine; Structure-Activity Relationship; Tumor Cells, Cultured

2002
Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins.
    The Journal of biological chemistry, 2002, Jul-26, Volume: 277, Issue:30

    Topics: Adenylate Kinase; Animals; Apoptosis; Cell Membrane; Ceramides; Cytochrome c Group; Detergents; Electrophoresis, Polyacrylamide Gel; Electrophysiology; Fumarate Hydratase; Male; Mitochondria; Mitochondria, Liver; Permeability; Rats; Rats, Sprague-Dawley; Sphingosine; Time Factors

2002
t-SNARE phosphorylation regulates endocytosis in yeast.
    Molecular biology of the cell, 2002, Volume: 13, Issue:5

    Topics: Endocytosis; Fungal Proteins; Ligands; Macromolecular Substances; Membrane Proteins; Membrane Transport Proteins; Phosphoprotein Phosphatases; Phosphorylation; Phosphotransferases; Pyridinium Compounds; Qa-SNARE Proteins; Quaternary Ammonium Compounds; R-SNARE Proteins; Receptors, Mating Factor; Receptors, Peptide; Saccharomyces cerevisiae Proteins; Sphingosine; Transcription Factors; Transport Vesicles; Yeasts

2002
Control of ceramide-induced apoptosis by IGF-1: involvement of PI-3 kinase, caspase-3 and catalase.
    Cell death and differentiation, 2002, Volume: 9, Issue:6

    Topics: Androstadienes; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Catalase; Enzyme Activation; Enzyme Inhibitors; HL-60 Cells; Humans; Insulin-Like Growth Factor I; Intracellular Membranes; Lipid Metabolism; Lipid Peroxidation; Membrane Potentials; Mitochondria; Oligopeptides; Oxidation-Reduction; Phosphatidylinositol 3-Kinases; Sphingosine; Wortmannin

2002
Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes.
    Cellular signalling, 2002, Volume: 14, Issue:9

    Topics: Adolescent; Cells, Cultured; Chromones; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Kinetics; Lysophospholipids; Melanins; Melanocytes; Microphthalmia-Associated Transcription Factor; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Monophenol Monooxygenase; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrones; Sphingosine; Transcription Factors

2002
Decreased activity and enhanced nuclear export of CCAAT-enhancer-binding protein beta during inhibition of adipogenesis by ceramide.
    The Biochemical journal, 2002, Jul-01, Volume: 365, Issue:Pt 1

    Topics: 3T3 Cells; Active Transport, Cell Nucleus; Adipocytes; Animals; CCAAT-Enhancer-Binding Protein-alpha; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Cell Line; DNA; Humans; Mice; Receptors, Cytoplasmic and Nuclear; Sphingosine; Stem Cells; Transcription Factors; Transcriptional Activation

2002
A non-IGF binding mutant of IGFBP-3 modulates cell function in breast epithelial cells.
    Biochemical and biophysical research communications, 2002, Jun-28, Volume: 294, Issue:5

    Topics: Apoptosis; Breast; Cell Division; Cell Line; Dose-Response Relationship, Drug; Epithelial Cells; Female; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Mutation; Somatomedins; Sphingosine; Tumor Cells, Cultured

2002
Effects of a non-IGF binding mutant of IGFBP-5 on cell death in human breast cancer cells.
    Biochemical and biophysical research communications, 2002, Jun-28, Volume: 294, Issue:5

    Topics: Apoptosis; Breast Neoplasms; Cell Division; Cell Line; Dose-Response Relationship, Drug; Female; Humans; Insulin-Like Growth Factor Binding Protein 5; Insulin-Like Growth Factor I; Mutation; Somatomedins; Sphingosine; Tumor Cells, Cultured

2002
Granulocyte colony-stimulating factor primes NADPH oxidase in neutrophils through translocation of cytochrome b(558) by gelatinase-granule release.
    The Journal of laboratory and clinical medicine, 2002, Volume: 140, Issue:1

    Topics: Cell Membrane; Cytochrome b Group; Cytosol; Dose-Response Relationship, Drug; Filgrastim; Gelatinases; Granulocyte Colony-Stimulating Factor; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Phospholipase D; Protein Transport; Recombinant Proteins; Secretory Vesicles; Sphingosine; Superoxides

2002
Human placental lipid induces mitogenesis and melanogenesis in B16F10 melanoma cells.
    Journal of biosciences, 2002, Volume: 27, Issue:3

    Topics: Animals; Cell Division; Cell Size; Cell Survival; Humans; Lipids; Lysophospholipids; Melanins; Melanoma; Mice; Placental Extracts; Sphingolipids; Sphingosine; Tumor Cells, Cultured

2002
Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis.
    Journal of neuroscience research, 2002, May-01, Volume: 68, Issue:3

    Topics: Animals; Animals, Newborn; Apoptosis; Brain; Cell Differentiation; Cell Membrane; Cell Survival; Cells, Cultured; Ceramides; Cerebellar Cortex; Cerebral Cortex; Dose-Response Relationship, Drug; Etoposide; Nerve Growth Factors; Neurons; Nucleic Acid Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Stress, Physiological; Up-Regulation

2002
High levels of exogenous C2-ceramide promote morphological and biochemical evidences of necrotic features in thyroid follicular cells.
    Journal of cellular biochemistry, 2002, Volume: 86, Issue:1

    Topics: Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Cell Membrane Permeability; Cells, Cultured; Dose-Response Relationship, Drug; fas Receptor; Humans; Membrane Potentials; Membrane Proteins; Microscopy, Electron; Mitochondria; Necrosis; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Sphingosine; Thyroid Gland

2002
Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway.
    The Journal of biological chemistry, 2002, Sep-27, Volume: 277, Issue:39

    Topics: Adenoviridae; Animals; Apoptosis; Astrocytes; Cannabinoids; Cell Survival; Ceramides; Glioma; Immunohistochemistry; Male; Mitogen-Activated Protein Kinases; Neurons; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; Sphingosine; Time Factors; Tumor Cells, Cultured

2002
Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways.
    Gastroenterology, 2002, Volume: 123, Issue:2

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Caspase 3; Caspases; Chromosomal Proteins, Non-Histone; Cytochrome c Group; Embryo Loss; fas Receptor; Female; Hepatocytes; Inhibitor of Apoptosis Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Mitochondria; Neoplasm Proteins; Oxidative Phosphorylation; Pregnancy; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Sphingosine; Survivin; Transcription, Genetic; Up-Regulation

2002
Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression.
    Journal of neurochemistry, 2002, Volume: 82, Issue:3

    Topics: Apoptosis; bcl-X Protein; Calpain; Caspases; Cell Death; Ceramides; Chromatin; DNA, Mitochondrial; Electron Transport; Electron Transport Complex II; Electron Transport Complex IV; Enzyme Activation; Enzyme Inhibitors; Glucose; Humans; Medulloblastoma; Mitochondria; Multienzyme Complexes; Oxidoreductases; Proto-Oncogene Proteins c-bcl-2; Pyruvic Acid; Sphingosine; Succinate Dehydrogenase; Transfection; Tumor Cells, Cultured

2002
Phosphorylation of cardiac protein kinase B is regulated by palmitate.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:3

    Topics: Animals; Cells, Cultured; Fatty Acids; Glucose; Hypoglycemic Agents; In Vitro Techniques; Insulin; Muscle Fibers, Skeletal; Myocardial Contraction; Myocardium; Oxidation-Reduction; Palmitates; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Sphingosine

2002
Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays.
    Genome biology, 2002, Jul-31, Volume: 3, Issue:8

    Topics: Animals; Apoptosis; Cell Differentiation; Gene Expression Profiling; Genes; Neurons; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; PC12 Cells; Rats; Signal Transduction; Sphingosine

2002
Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2.
    Hepatology (Baltimore, Md.), 2002, Volume: 36, Issue:3

    Topics: Apoptosis; Cells, Cultured; Cytochalasin D; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation, Enzymologic; Hepatocytes; Humans; Imidazoles; Matrix Metalloproteinase 2; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Mitogen-Activated Protein Kinases; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; Sphingosine

2002
Mitochondrial cytochrome c release precedes transmembrane depolarisation and caspase-3 activation during ceramide-induced apoptosis of Jurkat T cells.
    Apoptosis : an international journal on programmed cell death, 2002, Volume: 7, Issue:5

    Topics: Annexin A5; Apoptosis; Caspase 3; Caspases; Ceramides; Cytochrome c Group; Eukaryotic Cells; Fluorescein-5-isothiocyanate; Humans; Intracellular Membranes; Jurkat Cells; Membrane Potentials; Mitochondria; Phosphatidylserines; Sphingosine

2002
C(2)-ceramide-induced circular smooth muscle cell contraction involves PKC-epsilon and p44/p42 MAPK activation in cat oesophagus. Mitogen-activated protein kinase.
    Cellular signalling, 2002, Volume: 14, Issue:11

    Topics: Animals; Antibodies; Cats; Cells, Cultured; Dose-Response Relationship, Drug; Esophagus; Isoenzymes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle Contraction; Myocytes, Smooth Muscle; Peptides; Protein Kinase C; Protein Kinase C-epsilon; Signal Transduction; Sphingosine

2002
Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells.
    Biological chemistry, 2002, Volume: 383, Issue:6

    Topics: Amide Synthases; Apoptosis; Caspase Inhibitors; Caspases; Cathepsin D; Ceramides; Cytochrome c Group; DNA Fragmentation; Enzyme Inhibitors; Flow Cytometry; HT29 Cells; Humans; Immunoblotting; Lysosomes; Mitochondria; Morpholines; Nucleosomes; Sphingosine

2002
Effects of C2-ceramide on the Malme-3M melanoma cell line.
    Journal of dermatological science, 2002, Volume: 30, Issue:1

    Topics: Cell Cycle; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; HSP70 Heat-Shock Proteins; Humans; Melanins; Melanoma; Monophenol Monooxygenase; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Skin Neoplasms; Sphingosine; Tumor Cells, Cultured

2002
Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts: role of ceramide.
    Cellular signalling, 2002, Volume: 14, Issue:12

    Topics: Amidohydrolases; Animals; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Cell Line; Ceramidases; Ceramides; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Lysophospholipids; Mice; Mitogen-Activated Protein Kinases; Myristates; Osteoblasts; Osteocalcin; Phosphorylation; Propanolamines; Smad Proteins; Smad1 Protein; Sphingomyelin Phosphodiesterase; Sphingosine; Trans-Activators

2002
Inhibition of CTP:phosphocholine cytidylyltransferase by C(2)-ceramide and its relationship to apoptosis.
    Molecular pharmacology, 2002, Volume: 62, Issue:5

    Topics: Animals; Apoptosis; Choline-Phosphate Cytidylyltransferase; COS Cells; Enzyme Inhibitors; Haplorhini; Microscopy, Electron; Sphingosine

2002
Synthetic ceramides induce growth arrest or apoptosis by altering cellular redox status.
    Archives of biochemistry and biophysics, 2002, Nov-01, Volume: 407, Issue:1

    Topics: Apoptosis; Buthionine Sulfoximine; Cell Division; Cells, Cultured; Ceramides; Dose-Response Relationship, Drug; Glutathione; Humans; Jurkat Cells; Leukemia, T-Cell; Mitochondria; Monocytes; Oxidation-Reduction; Peroxides; Reactive Oxygen Species; Rotenone; Sphingosine

2002
Identification of platelet-activating factor acetylhydrolase II in human skin.
    The Journal of investigative dermatology, 2002, Volume: 119, Issue:4

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Apoptosis; Biological Transport; Cells, Cultured; Fluorescent Antibody Technique; Humans; Phospholipases A; Phospholipases A2; Phospholipids; Skin; Sphingosine; tert-Butylhydroperoxide; Ultraviolet Rays

2002
Slight impairment of Na+,K+-ATPase synergistically aggravates ceramide- and beta-amyloid-induced apoptosis in cortical neurons.
    Brain research, 2002, Nov-15, Volume: 955, Issue:1-2

    Topics: Amyloid beta-Peptides; Animals; Apoptosis; Cell Death; Cells, Cultured; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Fetus; Intracellular Fluid; Mice; Neocortex; Neurons; Peptide Fragments; Sodium-Potassium-Exchanging ATPase; Sphingosine

2002
Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway.
    Biochemical and biophysical research communications, 2002, Nov-29, Volume: 299, Issue:2

    Topics: Animals; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Caspases; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Humans; Kinetics; Mutation; Neurons; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingosine; Tumor Cells, Cultured

2002
Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria.
    The Journal of cell biology, 2002, Nov-25, Volume: 159, Issue:4

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calcium; Cells, Cultured; Endoplasmic Reticulum; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; HeLa Cells; Homeostasis; Humans; Ion Channels; Ion Transport; Mitochondria; Muscle Fibers, Skeletal; Porins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Recombinant Fusion Proteins; Sphingosine; Voltage-Dependent Anion Channels

2002
Gold sodium thiomalate (GSTM) inhibits lipopolysaccharide stimulated tumor necrosis factor-alpha through ceramide pathway.
    Cellular immunology, 2002, Volume: 219, Issue:1

    Topics: Adult; Antirheumatic Agents; Cells, Cultured; Ceramides; Female; Gold Sodium Thiomalate; Humans; Leukocytes, Mononuclear; Lipopolysaccharides; Male; NF-kappa B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sphingosine; Tumor Necrosis Factor-alpha

2002
Altered sphingolipid metabolism in N-(4-hydroxyphenyl)-retinamide-resistant A2780 human ovarian carcinoma cells.
    The Journal of biological chemistry, 2003, Feb-21, Volume: 278, Issue:8

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Drug Resistance, Neoplasm; Female; Fenretinide; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Ovarian Neoplasms; Sphingolipids; Sphingosine; Tumor Cells, Cultured

2003
Signaling events mediating activation of brain ethanolamine plasmalogen hydrolysis by ceramide.
    European journal of biochemistry, 2003, Volume: 270, Issue:1

    Topics: Animals; Brain; Caspase 3; Caspase Inhibitors; Caspases; Ceramides; Endothelin-1; Enzyme Inhibitors; Flavonoids; Hydrolysis; Male; Okadaic Acid; Phospholipases A; Phospholipases A2; Phospholipid Ethers; Phosphoprotein Phosphatases; Plasmalogens; Protein Phosphatase 2; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine

2003
Cellular regulation of sodium-calcium exchange.
    Annals of the New York Academy of Sciences, 2002, Volume: 976

    Topics: Animals; Axons; Calcium; Calcium Channels; CHO Cells; Cricetinae; Cytosol; Decapodiformes; Depsipeptides; Heart; Marine Toxins; Mitochondria; Mutagenesis, Site-Directed; Myocardial Contraction; Oxazoles; Peptides, Cyclic; Recombinant Proteins; Sodium; Sodium Channels; Sodium-Calcium Exchanger; Sphingosine; Transfection

2002
Ceramide increases oxidative damage due to inhibition of catalase by caspase-3-dependent proteolysis in HL-60 cell apoptosis.
    The Journal of biological chemistry, 2003, Mar-14, Volume: 278, Issue:11

    Topics: Apoptosis; Blotting, Northern; Blotting, Western; Caspase 3; Caspase 6; Caspase 8; Caspase 9; Caspases; Catalase; Ceramides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Gene Deletion; HL-60 Cells; Humans; Hydrogen Peroxide; Oxidative Stress; Oxygen; Peroxidase; Precipitin Tests; Reactive Oxygen Species; RNA; RNA, Messenger; Sphingosine; Thiobarbituric Acid Reactive Substances; Time Factors

2003
Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Volume: 9, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Cell Line; Cell Separation; Ceramides; DNA, Complementary; Dose-Response Relationship, Drug; Doxycycline; Drug Resistance, Neoplasm; Enzyme Activation; Flow Cytometry; Glucosyltransferases; HL-60 Cells; Humans; Leukemia; Middle Aged; Neoplasms; Propidium; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Transfection; Transferases (Other Substituted Phosphate Groups)

2003
Ceramide increases mitochondrial free calcium levels via caspase 8 and Bid: role in initiation of cell death.
    Journal of neurochemistry, 2003, Volume: 84, Issue:4

    Topics: Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Calcium; Carrier Proteins; Caspase 8; Caspase 9; Caspases; Cell Differentiation; Ceramides; Cytochrome c Group; Endoplasmic Reticulum; Mitochondria; Nerve Growth Factor; Neurons; PC12 Cells; Rats; Reactive Oxygen Species; Sphingosine

2003
Insulin or bFGF and C2 ceramide increase newborn rat retinal ganglion cell survival rate.
    Biochemical and biophysical research communications, 2003, Feb-07, Volume: 301, Issue:2

    Topics: Animals; Animals, Newborn; Carbazoles; Cell Separation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblast Growth Factor 2; Indole Alkaloids; Insulin; Okadaic Acid; Rats; Retinal Ganglion Cells; Signal Transduction; Sphingosine

2003
Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function.
    Diabetes, 2003, Volume: 52, Issue:3

    Topics: Adult; Aged; Apoptosis; Cell Division; Cells, Cultured; Cytochrome c Group; Cytosol; DNA Fragmentation; Fatty Acids, Monounsaturated; Fumonisins; Gene Expression; Genes, bcl-2; Glucose; Humans; In Situ Nick-End Labeling; Insulin; Insulin Secretion; Islets of Langerhans; Middle Aged; Mitochondria; Oleic Acid; Palmitic Acid; Sphingosine

2003
Potentiation of lipopolysaccharide-inducible cyclooxygenase 2 expression by C2-ceramide via c-Jun N-terminal kinase-mediated activation of CCAAT/enhancer binding protein beta in macrophages.
    Molecular pharmacology, 2003, Volume: 63, Issue:3

    Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Protein-delta; CCAAT-Enhancer-Binding Proteins; Cell Nucleus; Cells, Cultured; Collagen Type I; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; DNA; Drug Synergism; Enzyme Inhibitors; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Signal Transduction; Sphingosine; Transcription Factor AP-1; Transcription Factors; Transfection; Tumor Necrosis Factor-alpha

2003
Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis.
    Cancer letters, 2003, Feb-28, Volume: 191, Issue:1

    Topics: Animals; Apoptosis; Carcinogens; Cell Communication; Cell Line; Cell Transformation, Neoplastic; Ceramides; Dose-Response Relationship, Drug; Epithelial Cells; Gap Junctions; Liver; Molecular Structure; Rats; Rats, Inbred F344; Sphingosine; Structure-Activity Relationship

2003
Hippocampal programmed cell death after status epilepticus: evidence for NMDA-receptor and ceramide-mediated mechanisms.
    Epilepsia, 2003, Volume: 44, Issue:3

    Topics: Age Factors; Animals; Apoptosis; Ceramides; Disease Models, Animal; Dizocilpine Maleate; DNA Fragmentation; Dose-Response Relationship, Drug; Hippocampus; Injections, Intraperitoneal; Kainic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sphingosine; Status Epilepticus

2003
BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis.
    Science (New York, N.Y.), 2003, Apr-04, Volume: 300, Issue:5616

    Topics: Animals; Apoptosis; Arachidonic Acid; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Calcium; Calcium Signaling; Calcium-Transporting ATPases; Cell Fractionation; Cell Line, Transformed; Cells, Cultured; Endoplasmic Reticulum; Histamine; Hydrogen Peroxide; Ionomycin; Membrane Proteins; Mice; Mice, Knockout; Microscopy, Confocal; Microscopy, Immunoelectron; Mitochondria; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sphingosine

2003
Synthesis of non-natural C2-homo-ceramide and its apoptotic activity against HL-60 cells.
    Bioorganic & medicinal chemistry letters, 2003, Feb-24, Volume: 13, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Enzyme Inhibitors; HL-60 Cells; Humans; Sphingosine; Stereoisomerism; Structure-Activity Relationship

2003
Ceramide attenuates high glucose-induced cardiac contractile abnormalities in cultured adult rat ventricular myocytes.
    Cellular and molecular biology (Noisy-le-Grand, France), 2002, Volume: 48 Online Pub

    Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Enzyme Inhibitors; Glucose; Heart Ventricles; Male; Morpholines; Muscle Cells; Myocardial Contraction; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Sphingosine

2002
Mitochondrial effects with ceramide-induced cardiac apoptosis are different from those of palmitate.
    Archives of biochemistry and biophysics, 2003, Apr-15, Volume: 412, Issue:2

    Topics: Animals; Antimycin A; Apoptosis; Cells, Cultured; Chick Embryo; Cyclosporine; Electron Transport; Fluorescent Dyes; Heart; Membrane Potentials; Mitochondria, Heart; Myocardium; Organic Chemicals; Palmitic Acid; Rotenone; Sphingosine

2003
Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress.
    Journal of cell science, 2003, May-15, Volume: 116, Issue:Pt 10

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Apoptosis; Blotting, Western; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; Intracellular Membranes; Membrane Potentials; Mice; Microscopy, Confocal; Mitochondria; Neurons; Oxidative Stress; Phosphorylation; Precipitin Tests; Pyruvic Acid; Reactive Oxygen Species; Sodium-Potassium-Exchanging ATPase; Sphingosine; Staurosporine; Succinic Acid; Time Factors

2003
Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3beta, and induction of the mitochondrial-dependent intrinsic caspase pathway.
    Molecular and cellular neurosciences, 2003, Volume: 22, Issue:3

    Topics: Animals; Apoptosis; bcl-Associated Death Protein; Carrier Proteins; Caspases; Cells, Cultured; Cerebral Cortex; DNA-Binding Proteins; Enzyme Inhibitors; Forkhead Transcription Factors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Mitochondria; Nerve Tissue Proteins; Neurons; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Sphingosine; Transcription Factors

2003
Positive inotropic effect of ceramide in adult ventricular myocytes: mechanisms dissociated from its reduction in Ca2+ influx.
    American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:2

    Topics: Age Factors; Animals; Caffeine; Calcium; Cardiotonic Agents; Enzyme Inhibitors; Heart Ventricles; Male; Myocardial Contraction; Myocytes, Cardiac; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum; Sphingosine; Ventricular Function, Left

2003
Characterization of C2-ceramide-resistant HL-60 subline (HL-CR): involvement of PKC delta in C2-ceramide resistance.
    Experimental cell research, 2003, Jun-10, Volume: 286, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Division; Cell Membrane; Cholecalciferol; Drug Resistance; Eukaryotic Cells; Gene Expression Regulation, Enzymologic; HL-60 Cells; Humans; Isoenzymes; Protein Kinase C; Protein Kinase C-delta; Protein Transport; Sphingosine; Tetradecanoylphorbol Acetate; Tretinoin

2003
Mechanisms involved in exogenous C2- and C6-ceramide-induced cancer cell toxicity.
    Biochemical pharmacology, 2003, May-15, Volume: 65, Issue:10

    Topics: Apoptosis; Caspase 3; Caspases; Cell Survival; Ceramides; Cytochrome c Group; Enzyme Activation; Enzyme Inhibitors; Humans; NF-kappa B; Poly(ADP-ribose) Polymerases; Sphingosine; Tumor Cells, Cultured

2003
C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis.
    Neuroscience, 2003, Volume: 119, Issue:2

    Topics: Animals; Apoptosis; Blotting, Western; Cell Survival; Ceramides; Cerebral Cortex; Culture Media, Serum-Free; Culture Techniques; DNA-Binding Proteins; Early Growth Response Protein 1; Embryo, Mammalian; Enzyme Inhibitors; Female; Gene Expression Regulation; Green Fluorescent Proteins; Imidazoles; Immediate-Early Proteins; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Luminescent Proteins; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pregnancy; Proteins; Proto-Oncogene Proteins c-jun; Pyridines; Sphingosine; Subcellular Fractions; Time Factors; Transcription Factors; Transfection

2003
Caspase-3-dependent reactivation of latent herpes simplex virus type 1 in sensory neuronal cultures.
    Journal of neurovirology, 2003, Volume: 9, Issue:3

    Topics: Adenoviridae; Animals; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Colforsin; Cysteine Proteinase Inhibitors; Enzyme Activation; Ganglia, Spinal; Genetic Vectors; Herpesvirus 1, Human; Nerve Growth Factors; Nerve Tissue Proteins; Neurons, Afferent; Oligopeptides; Rats; Recombinant Fusion Proteins; Sphingosine; Tetradecanoylphorbol Acetate; Virus Activation; Virus Latency

2003
Apoptotic activities of C2-ceramide and C2-dihydroceramide homologues against HL-60 cells.
    Bioorganic & medicinal chemistry, 2003, Jul-03, Volume: 11, Issue:13

    Topics: Apoptosis; Caspase 3; Caspases; Ceramides; DNA Fragmentation; Dose-Response Relationship, Drug; HL-60 Cells; Humans; Kinetics; Poly Adenosine Diphosphate Ribose; Sphingosine; Structure-Activity Relationship

2003
C2-ceramide inhibits LPS-induced nitric oxide production in RAW 264.7 macrophage cells through down-regulating the activation of Akt.
    Journal of endotoxin research, 2003, Volume: 9, Issue:2

    Topics: Animals; Cell Line; Down-Regulation; Enzyme Inhibitors; Escherichia coli; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sphingosine; Transfection

2003
Prevalence of necrosis in C2-ceramide-induced cytotoxicity in NB16 neuroblastoma cells.
    Molecular pharmacology, 2003, Volume: 64, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Cell Survival; Enzyme Inhibitors; Humans; Necrosis; Neuroblastoma; Sphingosine; Tumor Cells, Cultured

2003
Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1.
    The Journal of biological chemistry, 2003, Oct-10, Volume: 278, Issue:41

    Topics: Animals; Apolipoprotein A-I; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Biological Transport, Active; Cell Line; Cell Membrane; Cells, Cultured; CHO Cells; Cholesterol; Cricetinae; HeLa Cells; Humans; Mice; Muscle, Smooth, Vascular; Recombinant Fusion Proteins; Sphingosine

2003
p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD.
    Molecular and cellular biology, 2003, Volume: 23, Issue:16

    Topics: Animals; Apoptosis; Camptothecin; cdc42 GTP-Binding Protein; Cell Survival; CHO Cells; COS Cells; Cricetinae; Cyclic AMP-Dependent Protein Kinases; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Galactose; Genetic Complementation Test; Glutathione Transferase; Immunoblotting; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase Kinases; Microscopy, Fluorescence; Mitochondria; Models, Biological; Mutation; p21-Activated Kinases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Serine-Threonine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sphingosine; Subcellular Fractions; Transfection

2003
Analysis of intracellular distribution and apoptosis involvement of the Ufd1l gene product by over-expression studies.
    Cell biochemistry and function, 2003, Volume: 21, Issue:3

    Topics: Adaptor Proteins, Vesicular Transport; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Apoptosis; Chlorocebus aethiops; Cloning, Molecular; COS Cells; Gene Expression Regulation; Genetic Vectors; Green Fluorescent Proteins; Humans; Inhibitor of Apoptosis Proteins; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Intracellular Space; Luminescent Proteins; Mice; Microscopy, Fluorescence; NIH 3T3 Cells; Proteins; Recombinant Fusion Proteins; Sphingosine; Transfection; Tumor Cells, Cultured; Viral Proteins

2003
Enlargement and contracture of C2-ceramide channels.
    Biophysical journal, 2003, Volume: 85, Issue:3

    Topics: Biophysical Phenomena; Biophysics; Cytochromes c; Edetic Acid; Electrophysiology; Ion Channels; Ions; Kinetics; Lanthanum; Lipids; Membrane Potentials; Membranes, Artificial; Models, Molecular; Sphingosine; Time Factors

2003
Decreased c-Myc expression and its involvement in X-ray-induced apoptotic cell death of human T-cell leukaemia cell line MOLT-4.
    International journal of radiation biology, 2003, Volume: 79, Issue:8

    Topics: Anisomycin; Apoptosis; Cell Line, Tumor; Cell Survival; Humans; Leukemia, T-Cell; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-myc; RNA, Messenger; Sphingosine; Tumor Suppressor Protein p53; X-Rays

2003
Ceramide inhibition of phospholipase D and its relationship to RhoA and ARF1 translocation in GTP gamma S-stimulated polymorphonuclear leukocytes.
    Blood, 2004, Mar-15, Volume: 103, Issue:6

    Topics: ADP-Ribosylation Factor 1; Bacterial Proteins; Cell Membrane; Cytosol; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Lactoferrin; Neutrophils; Phospholipase D; Phosphorylation; rhoA GTP-Binding Protein; Sphingosine; Streptolysins

2004
Prolactin acts as a potent survival factor against C2-ceramide-induced apoptosis in human granulosa cells.
    Human reproduction (Oxford, England), 2003, Volume: 18, Issue:12

    Topics: Apoptosis; Cell Count; Cell Survival; Cells, Cultured; Corpus Luteum; Dose-Response Relationship, Drug; Female; Flow Cytometry; Granulosa Cells; Humans; Progesterone; Prolactin; Sphingosine

2003
Commitment to apoptosis by ceramides depends on mitochondrial respiratory function, cytochrome c release and caspase-3 activation in Hep-G2 cells.
    Molecular and cellular biochemistry, 2003, Volume: 254, Issue:1-2

    Topics: Apoptosis; Caspase 3; Caspases; Cell Line; Cell Line, Tumor; Cell Nucleus; Cell Survival; Ceramides; Coloring Agents; Cytochromes c; DNA; DNA Fragmentation; Dose-Response Relationship, Drug; Electron Transport; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Flow Cytometry; Humans; Microscopy, Fluorescence; Mitochondria; Reactive Oxygen Species; Sphingosine; Tetrazolium Salts; Thiazoles; Time Factors

2003
(3Z)-2-Acetylamino-3-octadecen-1-ol as a potent apoptotic agent against HL-60 cells.
    Bioorganic & medicinal chemistry, 2004, Jan-02, Volume: 12, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Cell Death; HL-60 Cells; Humans; Oleic Acids; Sphingosine; Stereoisomerism

2004
Ceramide pathways modulate ethanol-induced cell death in astrocytes.
    Journal of neurochemistry, 2003, Volume: 87, Issue:6

    Topics: Amidohydrolases; Animals; Animals, Newborn; Astrocytes; Brain; Carrier Proteins; Caspase 3; Caspases; Cell Death; Cells, Cultured; Central Nervous System Depressants; Ceramidases; Chromatography, High Pressure Liquid; Coatomer Protein; Colorimetry; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Ethanol; Immunoblotting; In Vitro Techniques; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Myelin Basic Protein; p38 Mitogen-Activated Protein Kinases; Palmitates; Precipitin Tests; Proto-Oncogene Proteins c-jun; rab5 GTP-Binding Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingomyelin Phosphodiesterase; Sphingosine; Time Factors

2003
Inhibition of IL-10 receptor function in alveolar macrophages by Toll-like receptor agonists.
    Journal of immunology (Baltimore, Md. : 1950), 2004, Feb-15, Volume: 172, Issue:4

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antigens, Differentiation; Bronchoalveolar Lavage Fluid; CpG Islands; DNA-Binding Proteins; Dose-Response Relationship, Immunologic; Down-Regulation; Immunosuppressive Agents; Interleukin-10; Ligands; Lipopolysaccharides; Macrophage Activation; Macrophages, Alveolar; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88; Oligodeoxyribonucleotides; Receptors, Cell Surface; Receptors, Immunologic; Receptors, Interleukin; Receptors, Interleukin-10; Signal Transduction; Sphingosine; STAT3 Transcription Factor; Teichoic Acids; Toll-Like Receptor 2; Toll-Like Receptor 4; Toll-Like Receptors; Trans-Activators

2004
Ceramide influences neurite outgrowth and neuroblastoma cell apoptosis regulated by novel protein kinase C isoforms.
    Journal of neurochemistry, 2004, Volume: 89, Issue:6

    Topics: Apoptosis; Cell Count; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Isoenzymes; Neurites; Neuroblastoma; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Transport; rho-Associated Kinases; Sphingosine; Transfection; Tretinoin

2004
Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell death.
    Journal of neurochemistry, 2004, Volume: 89, Issue:6

    Topics: Antineoplastic Agents; beta-D-Galactoside alpha 2-6-Sialyltransferase; Caspase 3; Caspases; Cell Death; Cell Line, Tumor; Cell Membrane; Cell Survival; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Glioma; Glycoconjugates; Glycosylation; Humans; Morpholines; N-Acetylglucosaminyltransferases; Oligosaccharides; Sialyltransferases; Sphingosine; Staurosporine; Transfection

2004
Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells.
    Cancer research, 2004, Jun-15, Volume: 64, Issue:12

    Topics: Autophagy; Cell Death; Cell Line, Tumor; G2 Phase; Glioma; Humans; Intracellular Membranes; Membrane Potentials; Membrane Proteins; Mitochondria; Mitosis; Proto-Oncogene Proteins; Sphingosine; Transfection

2004
Prolactin acts as a potent survival factor for human breast cancer cell lines.
    British journal of cancer, 2004, Jul-19, Volume: 91, Issue:2

    Topics: Apoptosis; Breast Neoplasms; Cell Survival; Combined Modality Therapy; Enzyme Inhibitors; Female; Humans; Prolactin; Sphingosine; Tumor Cells, Cultured

2004
Enhancement of C2-ceramide antitumor activity by small interfering RNA on X chromosome-linked inhibitor of apoptosis protein in resistant human glioma cells.
    Journal of neurosurgery, 2004, Volume: 101, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Apoptosis Inducing Factor; Cell Culture Techniques; Cell Line, Tumor; Chromosomes, Human, X; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Flavoproteins; Glioma; Humans; Membrane Proteins; Proteins; RNA, Small Interfering; Sphingosine; X-Linked Inhibitor of Apoptosis Protein

2004
Reduced levels of the adenomatous polyposis coli (APC) protein are associated with ceramide-induced apoptosis of colon cancer cells.
    Journal of cancer research and clinical oncology, 2004, Volume: 130, Issue:12

    Topics: Adenomatous Polyposis Coli Protein; Apoptosis; Cell Cycle; Cell Proliferation; Ceramides; Chlorides; Colonic Neoplasms; Genes, p53; Humans; Sphingosine; Tumor Cells, Cultured; Zinc Compounds

2004
Nitric oxide acts on the mitochondria and protects human endothelial cells from apoptosis.
    The Journal of laboratory and clinical medicine, 2004, Volume: 144, Issue:3

    Topics: Apoptosis; Arthritis, Rheumatoid; Caspases; Cell Division; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Etoposide; Humans; Leupeptins; Mitochondria; Nitric Oxide; Nitric Oxide Donors; S-Nitroso-N-Acetylpenicillamine; Sphingosine

2004
Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, Oct-12, Volume: 101, Issue:41

    Topics: 3T3 Cells; Animals; Apoptosis; Cell Line, Transformed; Cell Survival; HL-60 Cells; Humans; Mice; Models, Biological; Sphingosine; U937 Cells

2004
Synergistic effect of interleukin (IL)-1alpha and ceramide analogue on the production of IL-6, IL-8, and macrophage colony-stimulating factor by endometrial stromal cells.
    Fertility and sterility, 2004, Volume: 82 Suppl 3

    Topics: Adult; Cells, Cultured; Ceramides; Endometrium; Female; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Interleukin-6; Interleukin-8; Macrophage Colony-Stimulating Factor; Sialoglycoproteins; Sphingosine; Stromal Cells

2004
Volume-sensitive chloride channels (ICl,vol) mediate doxorubicin-induced apoptosis through apoptotic volume decrease in cardiomyocytes.
    Fundamental & clinical pharmacology, 2004, Volume: 18, Issue:5

    Topics: Animals; Annexin A5; Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Cell Size; Cells, Cultured; Chloride Channels; Doxorubicin; Heart Ventricles; Male; Myocytes, Cardiac; Osmotic Pressure; Patch-Clamp Techniques; Rabbits; Sphingosine; Time Factors

2004
Mitochondrial dysfunction is a primary event in renal cell oxalate toxicity.
    Kidney international, 2004, Volume: 66, Issue:5

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Caspases; Cell Line; Dogs; Enzyme Activation; Enzyme Inhibitors; Intracellular Membranes; Kidney; Lipid Peroxidation; Lysophosphatidylcholines; Membrane Potentials; Mitochondria; Oxalates; Phospholipases A; Phospholipases A2; Reactive Oxygen Species; Sphingosine

2004
The mitochondrion--an organelle commonly involved in programmed cell death in Arabidopsis thaliana.
    The Plant journal : for cell and molecular biology, 2004, Volume: 40, Issue:4

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Arabidopsis; Arabidopsis Proteins; Flow Cytometry; Gene Expression Regulation, Plant; Light; Membrane Potentials; Mitochondria; Oxidoreductases; Plant Leaves; Protoplasts; Protoporphyrins; Sphingosine

2004
High sensitivity of fibroblast cell lines derived from LEC rats to heat treatment.
    The Journal of veterinary medical science, 2004, Volume: 66, Issue:10

    Topics: Animals; Anthracenes; Apoptosis; Cell Line; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Fibroblasts; Flow Cytometry; Hot Temperature; HSP70 Heat-Shock Proteins; Imidazoles; Immunoblotting; Pyridines; Rats; Rats, Inbred LEC; Sphingosine; Time Factors

2004
Enhancement of radiosensitivity by combined ceramide and dimethylsphingosine treatment in lung cancer cells.
    Experimental & molecular medicine, 2004, Oct-31, Volume: 36, Issue:5

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Carcinoma, Lewis Lung; Caspases; Cell Line, Tumor; Cell Survival; Gene Expression; Lung Neoplasms; Mice; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Radiation Tolerance; Radiation-Sensitizing Agents; Sphingosine

2004
Opposite regulation of the mitochondrial apoptotic pathway by C2-ceramide and PACAP through a MAP-kinase-dependent mechanism in cerebellar granule cells.
    Journal of neurochemistry, 2004, Volume: 91, Issue:5

    Topics: Animals; Animals, Newborn; bcl-2-Associated X Protein; Benzimidazoles; Blotting, Western; Carbocyanines; Caspase 3; Caspase 9; Caspases; Cells, Cultured; Cerebellum; Cytochromes c; Cytosol; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Fluorescent Antibody Technique; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Membrane Potentials; Mice; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Neurological; Nerve Growth Factors; Neurons; Neuropeptides; Neurotransmitter Agents; Pituitary Adenylate Cyclase-Activating Polypeptide; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sphingosine; Time Factors

2004
Ceramide enhances acrosomal exocytosis triggered by calcium and the calcium ionophore A23187 in boar spermatozoa.
    The Journal of reproduction and development, 2004, Volume: 50, Issue:6

    Topics: Acrosome; Acrosome Reaction; Amidohydrolases; Animals; Calcimycin; Calcium; Cell Survival; Ceramidases; Ceramides; Culture Media; Dose-Response Relationship, Drug; Embryo, Mammalian; Exocytosis; Ionophores; Male; Specimen Handling; Sperm Motility; Spermatozoa; Sphingosine; Swine; Temperature; Time Factors

2004
Pituitary adenylate cyclase-activating polypeptide prevents the effects of ceramides on migration, neurite outgrowth, and cytoskeleton remodeling.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Feb-15, Volume: 102, Issue:7

    Topics: Amino Acid Chloromethyl Ketones; Animals; Cell Movement; Cells, Cultured; Cerebellum; Cysteine Proteinase Inhibitors; Cytoskeleton; Microscopy, Video; Nerve Growth Factors; Nerve Tissue Proteins; Neurites; Neurons; Neuropeptides; Neurotransmitter Agents; Phosphoproteins; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Sphingosine; tau Proteins

2005
Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate.
    Blood, 2005, Jul-01, Volume: 106, Issue:1

    Topics: Angiogenesis Inhibitors; Animals; DNA, Complementary; Embryo, Nonmammalian; Endothelium, Vascular; Eye Abnormalities; Humans; Lysophospholipids; Magnesium; Neuropilin-1; Oligonucleotides, Antisense; Sphingomyelin Phosphodiesterase; Sphingosine; Thalidomide; Umbilical Veins; Vascular Endothelial Growth Factor Receptor-2; Zebrafish

2005
The 70 kilodalton heat shock protein is an inhibitor of apoptosis in prostate cancer.
    International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2004, Volume: 20, Issue:8

    Topics: Animals; Apoptosis; Caspase Inhibitors; Cell Line, Tumor; Cell Survival; Cell-Free System; DNA Fragmentation; DNA, Antisense; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heat-Shock Proteins; Heat-Shock Response; Hot Temperature; HSP70 Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Humans; In Situ Nick-End Labeling; Male; Mice; Prostatic Neoplasms; Quercetin; Serpins; Sphingosine; Viral Proteins

2004
Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Apr-01, Volume: 11, Issue:7

    Topics: ADAM Proteins; ADAM17 Protein; Amyloid Precursor Protein Secretases; Animals; Apoptosis; Ascitic Fluid; Aspartic Acid Endopeptidases; Binding, Competitive; Cell Hypoxia; Cell Line, Tumor; Cell Movement; CHO Cells; Cricetinae; Cricetulus; Cytoplasmic Vesicles; Endopeptidases; Extracellular Signal-Regulated MAP Kinases; Female; HeLa Cells; Humans; Metalloendopeptidases; Neural Cell Adhesion Molecule L1; Ovarian Neoplasms; Phosphorylation; Solubility; Sphingosine

2005
Ceramides induce programmed cell death in Arabidopsis cells in a calcium-dependent manner.
    Biological chemistry, 2005, Volume: 386, Issue:2

    Topics: Apoptosis; Arabidopsis; Calcium; Calcium Signaling; Cells, Cultured; Ceramides; In Situ Nick-End Labeling; Reactive Oxygen Species; Sphingosine

2005
Induction of apoptosis in chicken oviduct cells by C2-ceramide.
    Molecules and cells, 2005, Apr-30, Volume: 19, Issue:2

    Topics: Animals; Annexin A5; Apoptosis; bcl-X Protein; Caspases; Chickens; Enzyme Inhibitors; Female; Oviducts; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Sphingosine

2005
Molecular associations and surface-active properties of short- and long-N-acyl chain ceramides.
    Biochimica et biophysica acta, 2005, Jun-01, Volume: 1711, Issue:1

    Topics: Ceramides; Phospholipids; Sphingosine; Surface-Active Agents; Time Factors; Water

2005
Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines.
    Journal of neuroscience research, 2005, Aug-15, Volume: 81, Issue:4

    Topics: Androstadienes; Animals; Apoptosis; Brain Neoplasms; Caspase 3; Caspase 8; Caspases; Cell Division; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Humans; Membrane Microdomains; Oligodendroglioma; PC12 Cells; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Protein Kinase Inhibitors; PTEN Phosphohydrolase; Rats; Sphingosine; Staurosporine; Transfection; Tumor Suppressor Proteins; Wortmannin

2005
Metabolic activity: a novel indicator of neuronal survival in the murine dopaminergic cell line CAD.
    Journal of molecular neuroscience : MN, 2005, Volume: 27, Issue:1

    Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase Inhibitors; Caspases; Cell Line; Cell Survival; Cysteine Proteinase Inhibitors; Dopamine; Energy Metabolism; Mice; Neurons; Neuroprotective Agents; Neurotrophin 3; Sphingosine

2005
Death or survival: membrane ceramide controls the fate and activation of antigen-specific T-cells depending on signal strength and duration.
    Cellular signalling, 2006, Volume: 18, Issue:3

    Topics: Animals; Apoptosis; B-Lymphocytes; Caspase 3; Caspases; Cell Membrane; Cell Survival; DNA Fragmentation; fas Receptor; Humans; Interleukin-2; Kv1.3 Potassium Channel; Lymphocyte Activation; Membrane Potentials; Mice; Receptors, Antigen, T-Cell; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; T-Lymphocytes, Helper-Inducer; Time Factors

2006
Ceramide- and ERK-dependent pathway for the activation of CCAAT/enhancer binding protein by interleukin-1beta in hepatocytes.
    Journal of lipid research, 2005, Volume: 46, Issue:11

    Topics: Active Transport, Cell Nucleus; Acute-Phase Proteins; Animals; Biological Transport; CCAAT-Enhancer-Binding Proteins; Cell Nucleus; Ceramides; Collagen; Cytosol; DNA; Dose-Response Relationship, Drug; Drug Combinations; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hepatocytes; Immunoblotting; Inflammation; Interleukin-1; Laminin; Liver; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Oligonucleotides; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Protein Transport; Proteoglycans; Rats; Rats, Inbred F344; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine

2005
Ceramide decreases surfactant protein B gene expression via downregulation of TTF-1 DNA binding activity.
    American journal of physiology. Lung cellular and molecular physiology, 2006, Volume: 290, Issue:2

    Topics: DNA; Down-Regulation; Gene Expression Regulation; Hepatocyte Nuclear Factor 3-alpha; Humans; Lung Neoplasms; Lysophospholipids; Nuclear Proteins; Promoter Regions, Genetic; Protein Kinases; Pulmonary Surfactant-Associated Protein B; RNA, Messenger; Signal Transduction; Sphingosine; Thyroid Nuclear Factor 1; Transcription Factors; Tumor Cells, Cultured

2006
C2-ceramide exhibits antiproliferative activity and potently induces apoptosis in endometrial carcinoma.
    Oncology reports, 2005, Volume: 14, Issue:5

    Topics: Apoptosis; Carcinoma; Cell Cycle; Cell Proliferation; Cell Transformation, Neoplastic; Endometrial Neoplasms; Enzyme Inhibitors; Female; Humans; Phenotype; Sphingosine; Tumor Cells, Cultured

2005
C2-ceramide induces vasodilation in phenylephrine-induced pre-contracted rat thoracic aorta: role of RhoA/Rho-kinase and intracellular Ca2+ concentration.
    Naunyn-Schmiedeberg's archives of pharmacology, 2005, Volume: 372, Issue:3

    Topics: Animals; Aorta, Thoracic; Calcium; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Muscle, Smooth, Vascular; Phenylephrine; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; rho-Associated Kinases; Sphingosine; Tumor Necrosis Factor-alpha; Vasoconstriction; Vasodilation

2005
Regulation of Ca2+ signalling and Ca2+-mediated cell death by the transcriptional coactivator PGC-1alpha.
    Cell death and differentiation, 2006, Volume: 13, Issue:4

    Topics: Adrenergic beta-Agonists; Albuterol; Animals; Apoptosis; Calcium; Calcium Channels; Calcium Signaling; Enzyme Inhibitors; Heat-Shock Proteins; HeLa Cells; Histamine; Homeostasis; Humans; Inositol 1,4,5-Trisphosphate Receptors; Ion Channels; Membrane Transport Proteins; Mitochondria, Muscle; Mitochondrial Proteins; Mitochondrial Swelling; Muscle Fibers, Skeletal; Nuclear Respiratory Factor 1; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Receptors, Cytoplasmic and Nuclear; Sphingosine; Transcription Factors; Transfection; Uncoupling Protein 2

2006
Involvement of the ubiquitin-mediated proteolytic system in the signaling pathway induced by ceramide in primary astrocyte cultures.
    Developmental neuroscience, 2005, Volume: 27, Issue:6

    Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Astrocytes; Cell Nucleus; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; I-kappa B Proteins; NF-kappa B; Proteasome Endopeptidase Complex; Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; RNA, Messenger; Signal Transduction; Sphingosine; Ubiquitin; Up-Regulation

2005
Ceramide-induced preconditioning involves reactive oxygen species.
    Life sciences, 2006, Mar-06, Volume: 78, Issue:15

    Topics: Animals; Antioxidants; Catalase; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Rats; Rats, Long-Evans; Reactive Oxygen Species; Sphingosine; Superoxide Dismutase; Tiopronin

2006
Bcl-2 but not clusterin/apolipoprotein J protected human diploid fibroblasts and immortalized keratinocytes from ceramide-induced apoptosis: role of p53 in the ceramide response.
    Archives of biochemistry and biophysics, 2006, Jan-01, Volume: 445, Issue:1

    Topics: Apoptosis; Cell Line, Transformed; Clusterin; Cyclin-Dependent Kinase Inhibitor p21; Diploidy; Down-Regulation; Fibroblasts; Humans; Keratinocytes; Mutation; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sphingosine; Tumor Suppressor Protein p53

2006
9-O-acetyl GD3 protects tumor cells from apoptosis.
    International journal of cancer, 2006, Jul-01, Volume: 119, Issue:1

    Topics: Acetylation; Antibiotics, Antineoplastic; Apoptosis; Cell Line, Tumor; Daunorubicin; Enzyme Inhibitors; Gangliosides; Humans; Jurkat Cells; Leukemia, T-Cell; Melanoma; Sphingosine; Time Factors

2006
Amyloid beta peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes.
    Journal of neurochemistry, 2006, Volume: 97, Issue:3

    Topics: Amyloid beta-Peptides; Animals; Apoptosis Regulatory Proteins; Blotting, Western; Brain; Cell Death; Cell Fractionation; Cell Nucleus; Cytosol; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; MAP Kinase Kinase 4; Neuropeptides; Oligodendroglia; Phosphorylation; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Sphingomyelin Phosphodiesterase; Sphingosine; Tetrazolium Salts; Thiazoles; Time Factors; Transcription Factor AP-1

2006
Ceramide is a mediator of apoptosis in retina photoreceptors.
    Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:4

    Topics: Animals; Apoptosis; Ceramides; Cycloserine; Docosahexaenoic Acids; Enzyme Inhibitors; Fumonisins; Glucosyltransferases; Immunohistochemistry; Membrane Potentials; Mitochondria; Oxidative Stress; Paraquat; Photoreceptor Cells, Vertebrate; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Sphingosine

2006
Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation.
    The Journal of biological chemistry, 2006, Jul-07, Volume: 281, Issue:27

    Topics: Antigens, Polyomavirus Transforming; Apoptosis; bcl-2-Associated X Protein; Catalytic Domain; Cell Line, Tumor; Enzyme Inhibitors; Humans; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Binding; Protein Conformation; Protein Phosphatase 2; Sphingosine; Structure-Activity Relationship

2006
Apoptosis of human colon carcinoma HT-29 cells induced by ceramide.
    World journal of gastroenterology, 2006, Jun-14, Volume: 12, Issue:22

    Topics: Apoptosis; Cell Line, Tumor; Colonic Neoplasms; DNA Fragmentation; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Humans; Mitochondria; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine

2006
Interleukin-1beta induces hyperpolarization and modulates synaptic inhibition in preoptic and anterior hypothalamic neurons.
    Neuroscience, 2006, Sep-15, Volume: 141, Issue:4

    Topics: Analysis of Variance; Animals; Bicuculline; Cells, Cultured; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA Antagonists; Hypothalamus; Interleukin-1beta; Membrane Potentials; Mice; Mice, Knockout; Myeloid Differentiation Factor 88; Neural Inhibition; Neurons; Patch-Clamp Techniques; Potassium Channel Blockers; Receptors, Interleukin-1; Sodium Channel Blockers; Sphingosine; Synapses; Tetrodotoxin

2006
C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts.
    Endocrinology, 2006, Volume: 147, Issue:9

    Topics: Animals; Anisomycin; Cell Differentiation; Cell Line; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Humans; Inflammation; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; JNK Mitogen-Activated Protein Kinases; Kinetics; Mice; Myoblasts; Myogenin; Phosphoproteins; Phosphorylation; Receptor, IGF Type 1; Recombinant Proteins; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Necrosis Factor-alpha; Tyrosine

2006
Thrombospondin-1 C-terminal-derived peptide protects thyroid cells from ceramide-induced apoptosis through the adenylyl cyclase pathway.
    The international journal of biochemistry & cell biology, 2006, Volume: 38, Issue:12

    Topics: Adenylyl Cyclases; Animals; Apoptosis; Caspase 3; Cells, Cultured; Ceramides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Gene Expression Regulation; Peptides; RNA, Messenger; Sphingosine; Swine; Thrombospondin 1; Thyroid Gland

2006
Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I.
    Journal of lipid research, 2006, Volume: 47, Issue:12

    Topics: Animals; Apolipoprotein A-I; Apoptosis; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Biological Transport, Active; Ceramides; CHO Cells; Cholesterol; Cricetinae; Molecular Structure; Signal Transduction; Sphingosine; Stereoisomerism

2006
PACAP and C2-ceramide generate different AP-1 complexes through a MAP-kinase-dependent pathway: involvement of c-Fos in PACAP-induced Bcl-2 expression.
    Journal of neurochemistry, 2006, Volume: 99, Issue:4

    Topics: Animals; Animals, Newborn; Apoptosis; Cell Survival; Cells, Cultured; Cerebellar Cortex; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation; MAP Kinase Signaling System; Neurons; Phosphoprotein Phosphatases; Phosphorylation; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Phosphatase 2; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; Sphingosine; Transcription Factor AP-1; Transcriptional Activation

2006
L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells.
    Gynecologic oncology, 2007, Volume: 104, Issue:2

    Topics: Animals; Apoptosis; Cell Line; Cell Line, Tumor; CHO Cells; Cisplatin; Cricetinae; Cricetulus; Female; Humans; Neural Cell Adhesion Molecule L1; Ovarian Neoplasms; Sphingosine; Staurosporine; Transfection

2007
Ceramide induces apoptosis via a peroxisome proliferator-activated receptor gamma-dependent pathway.
    Apoptosis : an international journal on programmed cell death, 2006, Volume: 11, Issue:11

    Topics: Anilides; Apoptosis; Caspases; Colonic Neoplasms; HT29 Cells; Humans; PPAR gamma; Sphingosine

2006
[Effect of ceramide on apoptosis of human colon cancer HT-29 cells].
    Wei sheng yan jiu = Journal of hygiene research, 2006, Volume: 35, Issue:5

    Topics: Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Down-Regulation; Enzyme Inhibitors; Gene Expression; Humans; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; Sphingosine; Up-Regulation

2006
Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent.
    The Journal of endocrinology, 2006, Volume: 191, Issue:2

    Topics: Animals; Apoptosis; Biomarkers; Blotting, Western; Bone Development; Cell Differentiation; Cell Line; Cells, Cultured; Chondrocytes; Collagen Type II; Collagen Type X; Cytokines; Dose-Response Relationship, Drug; Growth Plate; High Mobility Group Proteins; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Metatarsal Bones; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinase 3; Oncogene Protein v-akt; Organ Culture Techniques; Phosphoproteins; Phosphorylation; SOX9 Transcription Factor; Sphingosine; Transcription Factors; Tyrphostins

2006
Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells.
    Diabetes, 2007, Volume: 56, Issue:2

    Topics: Actins; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Glucose Oxidase; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Muscle Fibers, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Transport; Proto-Oncogene Proteins c-akt; rac GTP-Binding Proteins; Receptor, Insulin; Sphingosine

2007
Ceramide induces apoptosis in human lung adenocarcinoma A549 cells through mitogen-activated protein kinases.
    Acta pharmacologica Sinica, 2007, Volume: 28, Issue:3

    Topics: Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Humans; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Sphingosine

2007
On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase.
    Biological chemistry, 2007, Volume: 388, Issue:3

    Topics: Animals; Ceramides; CHO Cells; Cricetinae; Cricetulus; Mice; Phospholipid Ethers; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Platelet Activating Factor; Sphingosine

2007
Impaired Fas-induced apoptosis of T lymphocytes in patients with abdominal aortic aneurysms.
    Journal of vascular surgery, 2007, Volume: 45, Issue:5

    Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Aortic Aneurysm, Abdominal; Apoptosis; Atherosclerosis; Autoimmunity; Down-Regulation; fas Receptor; Female; Glucocorticoids; Humans; Male; Methylprednisolone; Middle Aged; Sphingosine; T-Lymphocytes

2007
Mechanisms involved in ceramide-induced cell cycle arrest in human hepatocarcinoma cells.
    World journal of gastroenterology, 2007, Feb-21, Volume: 13, Issue:7

    Topics: Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Humans; Liver Neoplasms; PPAR gamma; Signal Transduction; Sphingosine

2007
Membrane microdomain formation is crucial in epiboly during gastrulation of medaka.
    Biochemical and biophysical research communications, 2007, Jul-06, Volume: 358, Issue:3

    Topics: Animals; beta-Cyclodextrins; Blastoderm; Cell Adhesion; Cell Membrane; Cholesterol; Detergents; Gastrula; Lewis X Antigen; Lipids; Membrane Microdomains; Oryzias; Sphingosine; Temperature

2007
Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells.
    The European journal of neuroscience, 2007, Volume: 25, Issue:10

    Topics: Animals; Apoptosis; Brain; Cell Differentiation; Cell Line, Tumor; Dopamine; Dose-Response Relationship, Drug; Down-Regulation; Energy Metabolism; Glycolysis; Insulin-Like Growth Factor I; Membrane Potential, Mitochondrial; Mesencephalon; Mice; Nerve Degeneration; Neurons; Parkinson Disease; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Sphingosine

2007
Inhibition of caspases but not of calpains temporarily protect against C2-ceramide-induced death of CAD cells.
    Neuroscience letters, 2007, Jun-29, Volume: 421, Issue:3

    Topics: Analysis of Variance; Animals; Calpain; Caspases; Cell Death; Cell Line; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Mice; Neurons; Neuroprotective Agents; Sphingosine; Tetrazolium Salts; Thiazoles; Time Factors

2007
The acylation of lipophilic alcohols by lysosomal phospholipase A2.
    Journal of lipid research, 2007, Volume: 48, Issue:10

    Topics: Acyltransferases; Alcohols; Animals; Cell Line; Dogs; Endosomes; Ethanol; Lysosomes; Models, Biological; Models, Chemical; Monoglycerides; Phosphatidylcholines; Phospholipases A2; Sphingosine; Time Factors

2007
Ceramide-induced cell death in lens epithelial cells.
    Molecular vision, 2007, Sep-10, Volume: 13

    Topics: Animals; Apoptosis; Caspases; Cattle; Cell Survival; Cells, Cultured; Ceramides; Dose-Response Relationship, Drug; Enzyme Activation; Epithelial Cells; Humans; Lens, Crystalline; Oxidative Stress; Reactive Oxygen Species; Sphingosine; Time Factors

2007
Ceramide inhibits development and cytokinesis and induces apoptosis in preimplantation bovine embryos.
    Molecular reproduction and development, 2008, Volume: 75, Issue:6

    Topics: Animals; Apoptosis; Blastocyst; Caspase 8; Caspase 9; Cattle; Cytokinesis; Embryonic Development; Female; Heat-Shock Response; In Vitro Techniques; Pregnancy; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine

2008
[Association between murine double minute 2 expression and AngII and ceramide induced endothelial cells apoptosis].
    Zhonghua xin xue guan bing za zhi, 2007, Volume: 35, Issue:10

    Topics: Angiotensin II; Apoptosis; Cells, Cultured; Endothelial Cells; Gene Expression; Humans; Imidazoles; Proto-Oncogene Proteins c-mdm2; Pyridines; RNA, Messenger; Sphingosine; Umbilical Veins

2007
C2-ceramide mediates cerebellar granule cells apoptosis by activation of caspases-2, -9, and -3.
    Journal of neuroscience research, 2008, Volume: 86, Issue:8

    Topics: Animals; Apoptosis; Caspase 2; Caspase 3; Caspase 9; Caspase Inhibitors; Cell Survival; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Rats; Sphingosine

2008
Bax siRNA promotes survival of cultured and allografted granule cell precursors through blockade of caspase-3 cleavage.
    Cell death and differentiation, 2008, Volume: 15, Issue:6

    Topics: Animals; bcl-2-Associated X Protein; Caspase 3; Caspase Inhibitors; Cell Survival; Cells, Cultured; Cerebellum; Neurons; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Rats, Wistar; RNA Interference; RNA, Small Interfering; Sphingosine; Stem Cell Transplantation; Stem Cells; Transplantation, Homologous

2008
Investigation on C2-ceramide complexes with transition metal ions using electrospray ionization tandem mass spectrometry.
    European journal of mass spectrometry (Chichester, England), 2008, Volume: 14, Issue:2

    Topics: Cell Membrane; Cobalt; Iron; Manganese; Metals; Nickel; Signal Transduction; Spectrometry, Mass, Electrospray Ionization; Sphingosine

2008
A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides.
    Analytical biochemistry, 2009, Jan-01, Volume: 384, Issue:1

    Topics: Animals; Benzothiazoles; Bridged-Ring Compounds; Cell Death; Cell Line; Ceramides; Chlorocebus aethiops; COS Cells; Humans; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Sphingosine; Transfection

2009
Activation of telomerase and cyclooxygenase-2 in PDGF and FGF inhibition of C2-ceramide-induced apoptosis.
    Journal of cellular physiology, 2009, Volume: 218, Issue:2

    Topics: Animals; Apoptosis; Cell Survival; Ceramides; Cyclooxygenase 2; Cytoprotection; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 2; JNK Mitogen-Activated Protein Kinases; Lysophospholipids; Mice; NIH 3T3 Cells; Phosphorylation; Platelet-Derived Growth Factor; Sphingosine; Telomerase

2009
Nerve growth factor, sphingomyelins, and sensitization in sensory neurons.
    Sheng li xue bao : [Acta physiologica Sinica], 2008, Oct-25, Volume: 60, Issue:5

    Topics: Action Potentials; Animals; Cells, Cultured; Ceramides; Lysophospholipids; Nerve Growth Factor; Patch-Clamp Techniques; Phosphotransferases (Alcohol Group Acceptor); Sensory Receptor Cells; Signal Transduction; Sphingomyelins; Sphingosine

2008
BM88/Cend1 regulates stimuli-induced intracellular calcium mobilization.
    Neuropharmacology, 2009, Volume: 56, Issue:3

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Apoptosis; Calcium; Calcium Signaling; Cell Differentiation; Cell Proliferation; Intracellular Fluid; Membrane Proteins; Mice; Molecular Sequence Data; Nerve Tissue Proteins; Neurogenesis; Neurons; Receptors, Purinergic P2; Sequence Alignment; Sphingosine; Transfection; Tumor Cells, Cultured

2009
[Mitochondrial changes in apoptosis of HT-29 cells induced by C2-ceramide].
    Wei sheng yan jiu = Journal of hygiene research, 2008, Volume: 37, Issue:5

    Topics: Apoptosis; Enzyme Inhibitors; HT29 Cells; Humans; Membrane Potential, Mitochondrial; Mitochondria; Sphingosine

2008
Lipid droplet biogenesis induced by stress involves triacylglycerol synthesis that depends on group VIA phospholipase A2.
    The Journal of biological chemistry, 2009, Feb-27, Volume: 284, Issue:9

    Topics: Animals; Anti-Bacterial Agents; Calcium; CHO Cells; Cricetinae; Cricetulus; Enzyme Inhibitors; Fatty Acid Synthases; Fatty Acids; Flow Cytometry; Fluorescence; Glucose; Group VI Phospholipases A2; Lipid Metabolism; Oxidative Stress; Phosphorylation; RNA, Small Interfering; Sphingosine; Triglycerides; Tunicamycin; Type C Phospholipases

2009
Retinal flavoprotein autofluorescence as a measure of retinal health.
    Transactions of the American Ophthalmological Society, 2008, Volume: 106

    Topics: Acetylcysteine; Adult; Aged; Antioxidants; Apoptosis; Cells, Cultured; Ceramides; Flavin-Adenine Dinucleotide; Fluorescence; Humans; Hydrogen Peroxide; Middle Aged; Mitochondria; Photography; Retina; Retinal Diseases; Retinal Pigment Epithelium; Sphingosine

2008
Docosahexaenoic acid down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the sphingomyelinase/ceramide pathway.
    The Journal of nutritional biochemistry, 2010, Volume: 21, Issue:4

    Topics: Adenylyl Cyclase Inhibitors; Animals; Cells, Cultured; Ceramides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytochrome P-450 CYP2B1; Docosahexaenoic Acids; Down-Regulation; Hepatocytes; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Time Factors; Transcriptional Activation

2010
Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons.
    Bioorganic & medicinal chemistry letters, 2009, Jun-15, Volume: 19, Issue:12

    Topics: Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Humans; Indazoles; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Pyrazoles; Sphingosine; Structure-Activity Relationship

2009
Potential mechanisms involved in ceramide-induced apoptosis in human colon cancer HT29 cells.
    Biomedical and environmental sciences : BES, 2009, Volume: 22, Issue:1

    Topics: Apoptosis; Caspases; Flow Cytometry; HT29 Cells; Humans; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Sphingosine

2009
Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
    Diabetes, 2009, Volume: 58, Issue:9

    Topics: Animals; Cell Line; Gene Expression Regulation, Enzymologic; Glucaric Acid; Humans; Insulin; Insulin-Secreting Cells; Islets of Langerhans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Palmitates; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Rats; RNA Precursors; RNA, Messenger; Sphingosine

2009
Alpha A-crystallin and alpha B-crystallin, newly identified interaction proteins of protease-activated receptor-2, rescue astrocytes from C2-ceramide- and staurosporine-induced cell death.
    Journal of neurochemistry, 2009, Volume: 110, Issue:5

    Topics: alpha-Crystallin A Chain; alpha-Crystallin B Chain; Animals; Astrocytes; Cell Death; Cell Line; Cells, Cultured; Humans; Immunoprecipitation; Insecta; Protein Binding; Rats; Receptor, PAR-2; Sphingosine; Staurosporine

2009
Cell-permeable ceramides act as novel regulators of U937 cell-cell adhesion mediated by CD29, CD98, and CD147.
    Immunobiology, 2010, Volume: 215, Issue:4

    Topics: Basigin; Cell Adhesion; Ceramides; Down-Regulation; Fibronectins; Fusion Regulatory Protein-1; Humans; Integrin alpha4; Integrin beta1; Phosphorylation; Sphingosine; U937 Cells

2010
Apoptotic inducers activate the release of D-aspartate through a hypotonic stimulus-triggered mechanism in PC12 cells.
    Archives of biochemistry and biophysics, 2009, Oct-15, Volume: 490, Issue:2

    Topics: Animals; Apoptosis; Aspartic Acid; Calcimycin; Hydrogen Peroxide; Hypotonic Solutions; Ion Channels; Ionophores; Nitrobenzoates; PC12 Cells; Rats; Sphingosine; Staurosporine; Stereoisomerism; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Uric Acid

2009
Synthesis of sphingosine is essential for oxidative stress-induced apoptosis of photoreceptors.
    Investigative ophthalmology & visual science, 2010, Volume: 51, Issue:2

    Topics: Animals; Apoptosis; Cells, Cultured; Cytochromes c; Docosahexaenoic Acids; Enzyme Inhibitors; In Situ Nick-End Labeling; Lysophospholipids; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Oxidants; Oxidative Stress; Palmitic Acid; Paraquat; Phosphotransferases (Alcohol Group Acceptor); Photoreceptor Cells, Vertebrate; Rats; Rats, Wistar; Reactive Oxygen Species; Sphingosine

2010
Chemotherapy induces ATP release from tumor cells.
    Cell cycle (Georgetown, Tex.), 2009, Nov-15, Volume: 8, Issue:22

    Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; Cadmium; Cell Line, Tumor; Cisplatin; Etoposide; Flow Cytometry; Fluorescent Antibody Technique; Mice; Mitomycin; Mitoxantrone; Neoplasms; Organoplatinum Compounds; Oxaliplatin; Sphingosine; Thapsigargin

2009
Functional modulation of mitochondria by eicosapentaenoic acid provides protection against ceramide toxicity to C6 glioma cells.
    Journal of agricultural and food chemistry, 2009, Dec-23, Volume: 57, Issue:24

    Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Caspase 3; Cell Line, Tumor; Cell Survival; Ceramides; Eicosapentaenoic Acid; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Proteins; Neurons; Neuroprotective Agents; Rats; Sphingosine; Transcription Factors

2009
Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C2-ceramide and CD95/APO-1/FAS receptor stimulation.
    Biochemical and biophysical research communications, 2010, Jan-01, Volume: 391, Issue:1

    Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Calcium; Caspase Inhibitors; Chelating Agents; Cysteine Proteinase Inhibitors; Egtazic Acid; Endoplasmic Reticulum; fas Receptor; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Mitochondria; Sphingosine

2010
Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes.
    Cardiovascular research, 2010, Apr-01, Volume: 86, Issue:1

    Topics: Animals; Antioxidants; Azoles; Cells, Cultured; Chloride Channels; Chlorides; Cyclopentanes; Estrogen Antagonists; Heart Ventricles; Indans; Isoindoles; Membrane Potentials; Myocytes, Cardiac; Organoselenium Compounds; Osmotic Pressure; Patch-Clamp Techniques; Rabbits; Reactive Oxygen Species; Sphingomyelin Phosphodiesterase; Sphingosine; Tamoxifen

2010
miR-181a and miR-630 regulate cisplatin-induced cancer cell death.
    Cancer research, 2010, Mar-01, Volume: 70, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cadmium Chloride; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Cycle; Cell Line, Tumor; Cisplatin; DNA Damage; HeLa Cells; Humans; Lung Neoplasms; MicroRNAs; Oligonucleotide Array Sequence Analysis; Phosphorylation; Sphingosine; Tumor Suppressor Protein p53; Up-Regulation

2010
Optimal suppression of protein phosphatase 2A activity is critical for maintenance of human embryonic stem cell self-renewal.
    Stem cells (Dayton, Ohio), 2010, Volume: 28, Issue:5

    Topics: Biomarkers; Cell Differentiation; Cell Division; Cell Line; Culture Media, Conditioned; Down-Regulation; Embryonic Stem Cells; Enzyme Activation; Enzyme Inhibitors; Humans; Okadaic Acid; Pluripotent Stem Cells; Protein Phosphatase 2; Signal Transduction; Sphingosine

2010
C2-ceramide inhibits the prostaglandin E2-induced accumulation of cAMP in human gingival fibroblasts.
    Biomedical research (Tokyo, Japan), 2010, Volume: 31, Issue:2

    Topics: Arthritis, Rheumatoid; Cell Differentiation; Ceramides; Colforsin; Dinoprostone; Fibroblasts; Gingiva; Humans; Methyl Ethers; Prostaglandins E; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; RNA, Messenger; Signal Transduction; Sphingomyelins; Sphingosine

2010
Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis.
    The FEBS journal, 2010, Volume: 277, Issue:16

    Topics: 14-3-3 Proteins; Apoptosis; Blotting, Western; Caspase 8; Cell Line, Tumor; Enzyme Inhibitors; Gene Expression Regulation; Gene Knockdown Techniques; Green Fluorescent Proteins; HeLa Cells; Humans; Mitochondria; Protein Binding; Proteomics; Reproducibility of Results; RNA, Small Interfering; Sphingosine

2010
Additive effects of C(2)-ceramide on paclitaxel-induced premature senescence of human lung cancer cells.
    Life sciences, 2010, Sep-11, Volume: 87, Issue:11-12

    Topics: Apoptosis; Baculoviral IAP Repeat-Containing 3 Protein; beta-Galactosidase; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; DNA Fragmentation; Extracellular Signal-Regulated MAP Kinases; G2 Phase; Gene Expression; GTP-Binding Proteins; Humans; Inhibitor of Apoptosis Proteins; JNK Mitogen-Activated Protein Kinases; Microfilament Proteins; Muscle Proteins; Osteonectin; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphorylation; Plasminogen Activator Inhibitor 1; Protein Glutamine gamma Glutamyltransferase 2; Proto-Oncogene Proteins c-bcl-2; Sphingosine; Transglutaminases; Ubiquitin-Protein Ligases

2010
Induction of apoptosis by sphingosine, sphinganine, and C(2)-ceramide in human colon cancer cells, but not by C(2)-dihydroceramide.
    Anticancer research, 2010, Volume: 30, Issue:7

    Topics: Apoptosis; Cell Cycle; Cell Division; Ceramides; Colonic Neoplasms; G2 Phase; HCT116 Cells; HT29 Cells; Humans; Sphingosine

2010
Differential regulation of AKT, MAPK and GSK3β during C2-ceramide-induced neuronal death.
    Neurotoxicology, 2010, Volume: 31, Issue:6

    Topics: Animals; Cell Death; Cell Survival; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Insulin-Like Growth Factor I; Mice; Mitogen-Activated Protein Kinases; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Sphingosine

2010
Regulation of autophagic activity by 14-3-3ζ proteins associated with class III phosphatidylinositol-3-kinase.
    Cell death and differentiation, 2011, Volume: 18, Issue:3

    Topics: 14-3-3 Proteins; Autophagy; Cell Extracts; Cell Line, Tumor; Chromatography, Affinity; Class III Phosphatidylinositol 3-Kinases; Down-Regulation; Enzyme Activation; HEK293 Cells; Humans; Phorbol Esters; Phosphorylation; Protein Binding; RNA, Small Interfering; Signal Transduction; Sphingosine

2011
Regulation of Sertoli cell activin A and inhibin B by tumour necrosis factor α and interleukin 1α: interaction with follicle-stimulating hormone/adenosine 3',5'-cyclic phosphate signalling.
    Molecular and cellular endocrinology, 2011, Mar-30, Volume: 335, Issue:2

    Topics: Animals; Bucladesine; Cells, Cultured; Cyclic AMP; Down-Regulation; Follicle Stimulating Hormone; Inhibin-beta Subunits; Inhibins; Interleukin-1alpha; Male; Phosphodiesterase Inhibitors; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, FSH; Recombinant Proteins; Sertoli Cells; Signal Transduction; Sphingosine; Stem Cell Factor; Transcription, Genetic; Tumor Necrosis Factor-alpha; Up-Regulation

2011
Friendly, and not so friendly, roles of Rac1 in islet β-cell function: lessons learnt from pharmacological and molecular biological approaches.
    Biochemical pharmacology, 2011, Apr-15, Volume: 81, Issue:8

    Topics: Animals; Apoptosis; Cell Line; Cytokines; Glucose; Guanine Nucleotide Exchange Factors; Insulin; Insulin Secretion; Insulin-Secreting Cells; Membrane Potential, Mitochondrial; NADPH Oxidases; Neoplasm Proteins; Oxidative Stress; Palmitates; rac1 GTP-Binding Protein; Rats; Reactive Oxygen Species; RNA, Small Interfering; Sphingosine; T-Lymphoma Invasion and Metastasis-inducing Protein 1; Transfection

2011
Role of JNK/ATF-2 pathway in inhibition of thrombospondin-1 (TSP-1) expression and apoptosis mediated by doxorubicin and camptothecin in FTC-133 cells.
    Biochimica et biophysica acta, 2011, Volume: 1813, Issue:5

    Topics: Activating Transcription Factor 2; Anthracenes; Apoptosis; Camptothecin; Caspase 3; Cell Line, Tumor; Cell Survival; Doxorubicin; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; Sphingosine; Thrombospondin 1; Thyroid Neoplasms

2011
Phosphorylation of Ser45 and Ser59 of αB-crystallin and p38/extracellular regulated kinase activity determine αB-crystallin-mediated protection of rat brain astrocytes from C2-ceramide- and staurosporine-induced cell death.
    Journal of neurochemistry, 2011, Volume: 118, Issue:3

    Topics: alpha-Crystallin B Chain; Animals; Astrocytes; Blotting, Western; Cell Death; Cell Survival; Cells, Cultured; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; JNK Mitogen-Activated Protein Kinases; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Receptor, PAR-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Sphingosine; Staurosporine

2011
Involvement of the sphingolipid ceramide in heat-shock-induced apoptosis of bovine oocytes.
    Reproduction, fertility, and development, 2011, Volume: 23, Issue:7

    Topics: Animals; Apoptosis; Blastocyst; Cattle; Cell Membrane; Ceramides; Cumulus Cells; DNA Fragmentation; Ectogenesis; Enzyme Inhibitors; Female; Fumonisins; Heat-Shock Response; Hot Temperature; Oocytes; Oogenesis; Osmolar Concentration; Oxidoreductases; Phosphatidylserines; Sphingolipids; Sphingosine; Time Factors

2011
Versican G3 domain modulates breast cancer cell apoptosis: a mechanism for breast cancer cell response to chemotherapy and EGFR therapy.
    PloS one, 2011, Volume: 6, Issue:11

    Topics: Animals; Anthracenes; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Survival; Docetaxel; Doxorubicin; Epirubicin; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Green Fluorescent Proteins; Humans; Mice; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sphingosine; Taxoids; Tyrphostins; Versicans

2011
C6-ceramide enhances Interleukin-12-mediated T helper type 1 cell responses through a cyclooxygenase-2-dependent pathway.
    Immunobiology, 2012, Volume: 217, Issue:6

    Topics: Animals; Cell Differentiation; Cell Membrane Permeability; Cells, Cultured; Ceramides; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Female; Gene Expression; Interferon-gamma; Interleukin-12; Mice; Mice, Inbred C57BL; Nitrobenzenes; Signal Transduction; Sphingosine; Sulfonamides; T-Box Domain Proteins; Th1 Cells

2012
PINK1 overexpression protects against C2-ceramide-induced CAD cell death through the PI3K/AKT pathway.
    Journal of molecular neuroscience : MN, 2012, Volume: 47, Issue:3

    Topics: Cell Death; Cell Line; Cell Survival; Humans; Mitochondrial Membranes; Parkinson Disease; Phosphatidylinositol 3-Kinases; Protein Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Sphingosine

2012
Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis.
    European journal of pharmacology, 2012, Mar-15, Volume: 679, Issue:1-3

    Topics: Animals; Apoptosis; Cerebral Cortex; Dose-Response Relationship, Drug; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; Pentacyclic Triterpenes; Primary Cell Culture; Rats; Reactive Oxygen Species; Signal Transduction; Sphingosine

2012
Specific phosphorylation of αA-crystallin is required for the αA-crystallin-induced protection of astrocytes against staurosporine and C2-ceramide toxicity.
    Neurochemistry international, 2012, Volume: 60, Issue:6

    Topics: alpha-Crystallin A Chain; Animals; Astrocytes; Cell Survival; Phosphorylation; Primary Cell Culture; Rats; Rats, Wistar; Sphingosine; Staurosporine

2012
Regulation of interleukin-1alpha and tumor necrosis factor-alpha-induced interleukin-8 production by amnion-derived (WISH) cells.
    Clinical and experimental obstetrics & gynecology, 2012, Volume: 39, Issue:1

    Topics: Amnion; Butadienes; Cell Line; Enzyme Inhibitors; Fumonisins; Humans; Imidazoles; Interleukin 1 Receptor Antagonist Protein; Interleukin-1alpha; Interleukin-8; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Pyridines; Sphingosine; Tumor Necrosis Factor-alpha

2012
Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis.
    Journal of neurochemistry, 2012, Volume: 123, Issue:4

    Topics: Amyloid beta-Peptides; Animals; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Etoposide; Gene Expression Regulation; Green Fluorescent Proteins; HSP70 Heat-Shock Proteins; Humans; Immunoprecipitation; Neural Inhibition; Neuroblastoma; Neurons; Peptide Fragments; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Binding; Rats; Signal Transduction; Sphingosine; Staurosporine; Transfection

2012
[Effect of ceramide on GSTA1 in Caco-2 cells].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2012, Volume: 47, Issue:7

    Topics: Caco-2 Cells; Enzyme Activation; Glutathione Transferase; Humans; RNA, Messenger; Sphingosine; Transcriptional Activation; Up-Regulation

2012
Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Sep-26, Volume: 32, Issue:39

    Topics: Alternative Splicing; Analysis of Variance; Animals; Animals, Newborn; Apoptosis; bcl-X Protein; Brain Injuries; CELF1 Protein; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Female; Functional Laterality; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Hypoxia-Ischemia, Brain; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Male; Mice; Neurons; Pregnancy; Rats; RNA Precursors; RNA-Binding Proteins; RNA, Small Interfering; Sphingosine; Staurosporine; Time Factors; Transfection

2012
Regulation of autophagy and its associated cell death by "sphingolipid rheostat": reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway.
    The Journal of biological chemistry, 2012, Nov-16, Volume: 287, Issue:47

    Topics: Animals; Autophagy; Ceramides; CHO Cells; Cricetinae; Cricetulus; Gene Knockdown Techniques; HL-60 Cells; Humans; Lysophospholipids; Phosphoprotein Phosphatases; Phosphorylation; Receptors, Lysosphingolipid; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; TOR Serine-Threonine Kinases

2012
Platelet protease-activated receptor (PAR)4, but not PAR1, associated with neutral sphingomyelinase responsible for thrombin-stimulated ceramide-NF-κB signaling in human platelets.
    Haematologica, 2013, Volume: 98, Issue:5

    Topics: Blood Platelets; Ceramides; Humans; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Platelet Activation; Platelet Aggregation; Protein Binding; Receptors, Thrombin; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Tandem Mass Spectrometry; Thrombin

2013
Palmitate induces RIP1-dependent necrosis in RAW 264.7 cells.
    Atherosclerosis, 2012, Volume: 225, Issue:2

    Topics: Animals; Antioxidants; Apoptosis; Cell Line; Cell Shape; Cell Survival; Cyclic N-Oxides; Dose-Response Relationship, Drug; GTPase-Activating Proteins; Imidazoles; Indoles; Macrophages; Metalloporphyrins; Mice; Microscopy, Electron, Transmission; Necrosis; Oxidative Stress; Palmitic Acid; Protein Kinase Inhibitors; Reactive Oxygen Species; RNA Interference; Sphingosine; Spin Labels; Transfection

2012
Neurotrophins regulate cholinergic synaptic transmission in cultured rat sympathetic neurons through a p75-dependent mechanism.
    Journal of neurophysiology, 2013, Volume: 109, Issue:2

    Topics: Animals; Brain-Derived Neurotrophic Factor; Cholinergic Neurons; Coculture Techniques; Excitatory Postsynaptic Potentials; Fumonisins; Myocytes, Cardiac; Nerve Growth Factor; Rats; Receptor, Nerve Growth Factor; Sphingosine; Superior Cervical Ganglion

2013
Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction.
    Atherosclerosis, 2013, Volume: 228, Issue:1

    Topics: Animal Feed; Animals; Apolipoprotein B-100; Cricetinae; Dietary Fats; Disease Models, Animal; Dyslipidemias; Fatty Acids, Monounsaturated; Fructose; Glucose Intolerance; Hepatitis; Immunosuppressive Agents; Insulin Resistance; Lipoproteins, VLDL; Liver; Male; Mesocricetus; Signal Transduction; Sphingolipids; Sphingosine

2013
Role of mitochondrial Bax, caspases, and MAPKs for ceramide-induced apoptosis in renal proximal tubular cells.
    Molecular and cellular biochemistry, 2013, Volume: 379, Issue:1-2

    Topics: Apoptosis; bcl-2-Associated X Protein; Caspase Inhibitors; Caspases; Cell Line; Enzyme Activation; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Kidney Tubules, Proximal; Mitochondria; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Sphingosine

2013
Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance.
    The Journal of biological chemistry, 2013, Jun-14, Volume: 288, Issue:24

    Topics: Animals; Cell Line; Cell Membrane; Cell Polarity; Enzyme Activation; Glucose Transporter Type 4; Guanine Nucleotide Exchange Factors; Humans; Insulin; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Neoplasm Proteins; Phosphatidylinositols; Phosphorylation; Protein Multimerization; Protein Processing, Post-Translational; Protein Transport; Proto-Oncogene Proteins c-akt; rac1 GTP-Binding Protein; Rats; Signal Transduction; Sphingosine; T-Lymphoma Invasion and Metastasis-inducing Protein 1

2013
Homocysteine induces cerebral endothelial cell death by activating the acid sphingomyelinase ceramide pathway.
    Progress in neuro-psychopharmacology & biological psychiatry, 2013, Aug-01, Volume: 45

    Topics: Amitriptyline; Animals; Cell Death; Cell Survival; Cerebral Cortex; Dose-Response Relationship, Drug; Endothelial Cells; Homocysteine; Mice; Primary Cell Culture; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Time Factors

2013
Correlation between potassium channel expression and sensitivity to drug-induced cell death in tumor cell lines.
    Current pharmaceutical design, 2014, Volume: 20, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Cell Death; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Cisplatin; Gene Expression Regulation, Neoplastic; Humans; Kv1.1 Potassium Channel; Kv1.3 Potassium Channel; Mitochondria; Neoplasms; Potassium Channel Blockers; RNA, Messenger; Sphingosine; Staurosporine; Tumor Burden

2014
Sphingosine-1-phosphate inhibits ceramide-induced apoptosis during murine preimplantation embryonic development.
    Theriogenology, 2013, Volume: 80, Issue:3

    Topics: Animals; Apoptosis; Blastocyst; Caspases; Embryo Culture Techniques; Embryonic Development; Female; Gene Expression Regulation, Developmental; Lysophospholipids; Mice; Pregnancy; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Tumor Suppressor Protein p53

2013
C2-phytoceramide perturbs lipid rafts and cell integrity in Saccharomyces cerevisiae in a sterol-dependent manner.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Cell Death; Cell Survival; Cell Wall; Ergosterol; G2 Phase Cell Cycle Checkpoints; Gene Expression; Humans; Membrane Microdomains; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Signal Transduction; Sphingosine

2013
Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway.
    Cell death & disease, 2013, Oct-03, Volume: 4

    Topics: Aged; Antibodies, Monoclonal; Apoptosis; Arginine; Case-Control Studies; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Culture Media, Serum-Free; Doxorubicin; Enzyme Activation; fas Receptor; Female; Fibroblasts; Humans; JNK Mitogen-Activated Protein Kinases; Male; Middle Aged; Signal Transduction; Sphingosine

2013
Protein tyrosine phosphatase 1B inhibition ameliorates palmitate-induced mitochondrial dysfunction and apoptosis in skeletal muscle cells.
    Free radical biology & medicine, 2013, Volume: 65

    Topics: Active Transport, Cell Nucleus; Adenosine Triphosphate; Apoptosis; Caspase 3; Caspase 9; Cell Line; Cell Survival; DNA-Binding Proteins; Forkhead Box Protein O1; Forkhead Transcription Factors; Humans; Insulin; JNK Mitogen-Activated Protein Kinases; Mitochondria; Mitochondrial Proteins; Muscle Fibers, Skeletal; Muscle, Skeletal; Nuclear Respiratory Factor 1; Palmitates; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Sirtuin 1; Sphingosine; Transcription Factor RelA; Transcription Factors

2013
Liposomal codelivery of a synergistic combination of bioactive lipids in the treatment of acute myeloid leukemia.
    Nanomedicine (London, England), 2014, Volume: 9, Issue:11

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Ceramides; Cholesterol; Chromatography, Liquid; Drug Delivery Systems; Female; Humans; Inhibitory Concentration 50; Leukemia, Myeloid, Acute; Lipids; Liposomes; Mice; Mice, Inbred BALB C; Mice, SCID; Phosphatidylcholines; Sphingosine; Tandem Mass Spectrometry; U937 Cells; Xenograft Model Antitumor Assays

2014
Hypermethylation contributes to down-regulation of lysosomal β-hexosaminidase α subunit in prostate cancer cells.
    Biochimie, 2014, Volume: 101

    Topics: beta-Hexosaminidase alpha Chain; Cell Line, Tumor; DNA Methylation; Down-Regulation; Enzyme Repression; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Male; Promoter Regions, Genetic; Prostatic Neoplasms; Sphingosine

2014
C2-ceramide induces cell death and protective autophagy in head and neck squamous cell carcinoma cells.
    International journal of molecular sciences, 2014, Feb-21, Volume: 15, Issue:2

    Topics: Apoptosis; Autophagy; Carcinoma, Squamous Cell; Caspase 3; Cell Line, Tumor; DNA Fragmentation; Head and Neck Neoplasms; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Necrosis; Phosphorylation; Signal Transduction; Sphingosine; TOR Serine-Threonine Kinases

2014
Ceramide inhibits insulin-stimulated Akt phosphorylation through activation of Rheb/mTORC1/S6K signaling in skeletal muscle.
    Cellular signalling, 2014, Volume: 26, Issue:7

    Topics: Animals; Cell Line; Enzyme Activation; Glucose; HEK293 Cells; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Luciferases; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Monomeric GTP-Binding Proteins; Multiprotein Complexes; Muscle Fibers, Skeletal; Neuropeptides; Phosphorylation; Protein Kinase C-delta; Proto-Oncogene Proteins c-akt; Ras Homolog Enriched in Brain Protein; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; RNA Interference; RNA, Small Interfering; Signal Transduction; Sirolimus; Sphingosine; TOR Serine-Threonine Kinases

2014
Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells.
    Neurotoxicology, 2014, Volume: 44

    Topics: Animals; Apoptosis; Cell Line, Tumor; Dopaminergic Neurons; Down-Regulation; Gene Knockdown Techniques; Humans; Mice; Mitochondria; Mitochondrial Proteins; Protein Kinases; Rotenone; Sphingosine

2014
Ceramide changes the mediator of flow-induced vasodilation from nitric oxide to hydrogen peroxide in the human microcirculation.
    Circulation research, 2014, Aug-15, Volume: 115, Issue:5

    Topics: Adipose Tissue; Adult; Aged; Antioxidants; Arterioles; Case-Control Studies; Coronary Artery Disease; Coronary Circulation; Coronary Vessels; Enzyme Inhibitors; Female; Humans; Hydrogen Peroxide; Male; Microcirculation; Microscopy, Video; Middle Aged; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Regional Blood Flow; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Time Factors; Vasodilation

2014
Ceramide signaling in the coronary microcirculation: a double-edged sword?
    Circulation research, 2014, Aug-15, Volume: 115, Issue:5

    Topics: Adipose Tissue; Coronary Artery Disease; Coronary Circulation; Coronary Vessels; Female; Humans; Hydrogen Peroxide; Male; Microcirculation; Nitric Oxide; Sphingosine; Vasodilation

2014
Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells.
    Biochimica et biophysica acta, 2015, Volume: 1852, Issue:5

    Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Caveolin 1; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Free Radical Scavengers; Hydrogen Peroxide; Insulin-Secreting Cells; Male; Membrane Potential, Mitochondrial; Mice, Inbred C57BL; Microscopy, Confocal; Oxidants; Palmitates; Phosphorylation; Pyrimidines; Reactive Oxygen Species; Sphingosine; src-Family Kinases; Tyrosine

2015
Differential apoptotic effect and metabolism of N-acetylsphingosine and N-hexanoylsphingosine in CHP-100 human neurotumor cells.
    Biochemical and biophysical research communications, 2015, Mar-13, Volume: 458, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Ceramides; Humans; Neoplasms, Neuroepithelial; Neuroepithelial Cells; Sphingosine

2015
Extracellular α-crystallin protects astrocytes from cell death through activation of MAPK, PI3K/Akt signaling pathway and blockade of ROS release from mitochondria.
    Brain research, 2015, Sep-16, Volume: 1620

    Topics: alpha-Crystallins; Animals; Antimycin A; Astrocytes; Brain; Cell Death; Cell Survival; Cells, Cultured; Escherichia coli; Extracellular Space; MAP Kinase Signaling System; Mitochondria; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Sphingosine; Staurosporine; TOR Serine-Threonine Kinases

2015
Analysis of lipid-composition changes in plasma membrane microdomains.
    Journal of lipid research, 2015, Volume: 56, Issue:8

    Topics: Animals; Cell Line; Gene Knockout Techniques; Lipid Metabolism; Lipids; Membrane Microdomains; Mice; Silicon Dioxide; Sphingosine; Transferases (Other Substituted Phosphate Groups)

2015
Overexpression of DJ-1 protects against C2-ceramide-induced neuronal death through activation of the PI3K/AKT pathway and inhibition of autophagy.
    Neuroscience letters, 2015, Aug-31, Volume: 603

    Topics: Animals; Autophagy; Cell Line; Cell Survival; Mice; Neurons; Oncogene Proteins; Peroxiredoxins; Phosphatidylinositol 3-Kinases; Protein Deglycase DJ-1; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Sphingosine; TOR Serine-Threonine Kinases

2015
[Ceramide participates in cell programmed death induced by Type II anti-CD20 mAb].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2015, Volume: 40, Issue:12

    Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Cell Line, Tumor; Humans; Lymphoma, Non-Hodgkin; Rituximab; Sphingosine

2015
Direct regulation of IGF-binding protein 1 promoter by interleukin-1β via an insulin- and FoxO-1-independent mechanism.
    American journal of physiology. Endocrinology and metabolism, 2016, Apr-15, Volume: 310, Issue:8

    Topics: Animals; Blotting, Western; Extracellular Signal-Regulated MAP Kinases; Forkhead Box Protein O1; Gene Expression Regulation; Glucose; Hep G2 Cells; Hepatocytes; Humans; Insulin; Insulin-Like Growth Factor Binding Protein 1; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred F344; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sphingomyelin Phosphodiesterase; Sphingosine

2016
Acid sphingomyelinase mediates 50-Hz magnetic field-induced EGF receptor clustering on lipid raft.
    Journal of receptor and signal transduction research, 2016, Volume: 36, Issue:6

    Topics: Amnion; Epithelial Cells; ErbB Receptors; Humans; Imipramine; Magnetic Fields; Membrane Microdomains; Phosphorylation; Sphingomyelin Phosphodiesterase; Sphingosine

2016
C2-ceramide enhances sorafenib-induced caspase-dependent apoptosis via PI3K/AKT/mTOR and Erk signaling pathways in HCC cells.
    Applied microbiology and biotechnology, 2017, Volume: 101, Issue:4

    Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Flow Cytometry; Humans; Niacinamide; Phenylurea Compounds; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Sorafenib; Sphingosine; TOR Serine-Threonine Kinases

2017
The TrkA receptor mediates experimental thermal hyperalgesia produced by nerve growth factor: Modulation by the p75 neurotrophin receptor.
    Neuroscience, 2017, 01-06, Volume: 340

    Topics: Analgesics; Aniline Compounds; Animals; Antibodies; Benzylidene Compounds; Carbazoles; Disease Models, Animal; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Indole Alkaloids; Male; Nerve Growth Factor; Nerve Tissue Proteins; Protein Kinase C; Rats, Sprague-Dawley; Receptor, trkA; Receptors, Growth Factor; Receptors, Nerve Growth Factor; Sphingosine; Touch; TRPV Cation Channels

2017
Preferential hydrolysis of truncated oxidized glycerophospholipids by lysosomal phospholipase A2.
    Journal of lipid research, 2017, Volume: 58, Issue:2

    Topics: Acylation; Amiodarone; Animals; CHO Cells; Cricetulus; Fatty Acids; Glycerophospholipids; Hydrogen-Ion Concentration; Hydrolysis; Liposomes; Lysosomes; Oxidation-Reduction; Phosphatidylcholines; Phospholipases A2; Sphingosine

2017
C2-ceramide influences alveolar epithelial barrier function by downregulating Zo-1, occludin and claudin-4 expression.
    Toxicology mechanisms and methods, 2017, Volume: 27, Issue:4

    Topics: Alveolar Epithelial Cells; Animals; Apoptosis; Cell Survival; Claudin-4; Dose-Response Relationship, Drug; Down-Regulation; Mice; Mice, Inbred ICR; Occludin; Permeability; Primary Cell Culture; Pulmonary Edema; Sphingosine; Zonula Occludens-1 Protein

2017
Autophagy inhibits C2-ceramide-mediated cell death by decreasing the reactive oxygen species levels in SH-SY5Y cells.
    Neuroscience letters, 2017, 06-09, Volume: 651

    Topics: Autophagy; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Sphingosine

2017
Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs.
    Molecular & cellular proteomics : MCP, 2019, Volume: 18, Issue:3

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Gene Expression Regulation; Mice; Phosphoproteins; Phosphorylation; Piperazines; Protein Phosphatase 2; Proteomics; Signal Transduction; Sphingolipids; Sphingosine

2019
Evaluation of chemotherapeutic and cancer-protective properties of sphingosine and C2-ceramide in a human breast stem cell derived carcinogenesis model.
    International journal of oncology, 2019, Volume: 54, Issue:2

    Topics: Breast; Breast Neoplasms; Carcinogenesis; Cell Differentiation; Cell Transformation, Neoplastic; Epithelial Cells; Female; Humans; MCF-7 Cells; Neoplastic Stem Cells; Sphingosine; Stem Cells

2019
Acetaminophen-induced hepatocyte injury: C2-ceramide and oltipraz intervention, hepatocyte nuclear factor 1 and glutathione S-transferase A1 changes.
    Journal of applied toxicology : JAT, 2019, Volume: 39, Issue:12

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Cell Culture Techniques; Cell Proliferation; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Gene Expression; Glutathione Transferase; Hep G2 Cells; Hepatocyte Nuclear Factor 1; Hepatocytes; Humans; Pyrazines; Sphingosine; Thiones; Thiophenes

2019
Ceramide: a novel inducer for neural tube defects.
    Developmental dynamics : an official publication of the American Association of Anatomists, 2019, Volume: 248, Issue:10

    Topics: Animals; Cell Line; Ceramides; Chick Embryo; Glutathione; Mice; Neural Tube Defects; Neurulation; Oxidation-Reduction; Oxidative Stress; PAX3 Transcription Factor; Reactive Oxygen Species; Sphingosine

2019
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease.
    Nature communications, 2020, 05-12, Volume: 11, Issue:1

    Topics: Acetyl Coenzyme A; Acetylation; Alzheimer Disease; Animals; Anti-Inflammatory Agents; Brain; Cell Line; Cyclooxygenase 2; Disease Models, Animal; Humans; Male; Memory; Mice; Mice, Transgenic; Microglia; Mutagenesis; Neurons; Phagocytosis; Phosphotransferases (Alcohol Group Acceptor); Presenilin-1; Primary Cell Culture; Recombinant Proteins; Serine; Sphingosine

2020
Esterification of side-chain oxysterols by lysosomal phospholipase A2.
    Biochimica et biophysica acta. Molecular and cell biology of lipids, 2020, Volume: 1865, Issue:10

    Topics: Animals; Catalysis; Cholesterol; Esterification; Humans; Hydroxycholesterols; Lysosomes; Macrophages; Mice; Oxysterols; Phosphatidylcholine-Sterol O-Acyltransferase; Phospholipases A2; Sphingosine

2020
Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway.
    Journal of applied toxicology : JAT, 2021, Volume: 41, Issue:12

    Topics: Chemical and Drug Induced Liver Injury; Glutathione Transferase; Hep G2 Cells; Hepatocyte Nuclear Factor 1-alpha; Humans; MAP Kinase Signaling System; Pyrazines; Sphingosine; Thiones; Thiophenes

2021