n-acetylsphingosine has been researched along with sphingosine in 486 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 158 (32.51) | 18.2507 |
| 2000's | 259 (53.29) | 29.6817 |
| 2010's | 65 (13.37) | 24.3611 |
| 2020's | 4 (0.82) | 2.80 |
| Authors | Studies |
|---|---|
| Adachi, K; Hattori, T; Shizuri, Y | 1 |
| Edinger, AL; Hanessian, S; Kim, SM; McCracken, AN; Nguyen, DG; O'Donoghue, H; Perryman, MS; Rafelski, S; Simitian, GS; Tessier, J; Viana, M; Wiher, T | 1 |
| Deli, E; Kiss, Z | 2 |
| Ghidoni, R; Kirschner, G; Leon, A; Miglio, A; Pitto, M | 1 |
| Cline, HT; Constantine-Paton, M | 1 |
| Benedict, M; Dixit, VM; Jäättelä, M; Shayman, JA; Tewari, M | 1 |
| Ishikura, H; Okano, H; Okazaki, T; Okuma, M; Sawada, H; Sawai, H; Takeda, Y; Tashima, M; Umehara, H; Yamamoto, H | 1 |
| Farach-Carson, MC; Karin, NJ; Liu, R | 1 |
| Ridgway, ND | 1 |
| Law, B; Rossie, S | 1 |
| Hunchuk, N; Li, XB; Wong, K | 1 |
| Jones, MJ; Murray, AW | 1 |
| Allin, J; Ladenson, RC; Monsey, JD; Silbert, DF | 1 |
| Lee, TC; Malone, B; Ou, MC; Shinozaki, K; Snyder, F | 1 |
| Koretzky, GA; Latinis, KM | 1 |
| Birrer, MJ; Bose, R; Fuks, Z; Grant, S; Haimovitz-Friedman, A; Jarvis, WD; Kolesnick, RN; Kyriakis, JM; Lin, XH; Szabo, E; Verheij, M; Yao, B; Zon, LI | 1 |
| Broach, JR; Nickels, JT | 1 |
| Welsh, N | 1 |
| Dawson, G; Wiesner, DA | 1 |
| Coso, OA; Cuvillier, O; Gutkind, S; Kleuser, B; Pirianov, G; Spiegel, S; Vanek, PG | 1 |
| Abe, A; Radin, NS; Shayman, JA | 1 |
| Chun, SY; Eisenhauer, K; Hsueh, AJ; Kaipia, A | 1 |
| Handa, S; Kohsaka, H; Koike, R; Kushi, Y; Miyasaka, N; Mizushima, N; Yagita, H | 1 |
| Chmura, SJ; Crane, MA; Hallahan, DE; Nodzenski, E; Quintans, J; Virudachalam, S; Weichselbaum, RR | 1 |
| Hirokawa, M; Horiuchi, T; Kawabata, Y; Kitabayashi, A; Kuroki, J; Lee, M; Miura, AB | 1 |
| Cavazzoni, M; Orlati, S; Rugolo, M | 1 |
| Boxer, LA; Hinkovska-Galcheva, V; Mansfield, PJ; Shayman, JA; Suchard, SJ | 1 |
| Beckett, MA; Chmura, SJ; Kufe, DW; Nodzenski, E; Quintans, J; Weichselbaum, RR | 1 |
| Colell, A; Fernández-Checa, JC; García-Ruiz, C; Marí, M; Morales, A | 1 |
| Bredesen, DE; Foster, LM; Kayalar, C; Keane, RW; Nonner, D; Ord, T; Reed, JC; Srinivasan, A; Testa, MP; Wang, HG | 1 |
| Farooq, M; Larocca, JN; Norton, WT | 1 |
| He, J; Oleinick, NL; Separovic, D | 1 |
| Igarashi, Y; Nishiyama, K; Ohi, Y; Ozawa, M; Sakakura, C; Shirahama, T; Sweeney, EA; Takemoto, M | 1 |
| Nakabo, Y; Pabst, MJ | 1 |
| Hori, Y; Shinkai, M; Takeyama, Y; Ueda, T; Yamamoto, M | 1 |
| Cagnoli, CM; Manev, H | 1 |
| Beham, A; Herrmann, JL; McDonnell, TJ; Menter, DG; von Eschenbach, A | 1 |
| Brossmer, R; Geilen, CC; Hannun, YA; Ihrig, P; Kolter, T; Orfanos, CE; Perry, D; Sadeghlar, F; Sandhoff, K; Wieder, T | 1 |
| Chow, SC; Orrenius, S; Pörn-Ares, MI; Slotte, JP | 1 |
| Johnson, GV; Xie, H | 1 |
| Gudz, TI; Hoppel, CL; Tserng, KY | 1 |
| Kaida, T; Kozawa, O; Suzuki, A; Tokuda, H; Uematsu, T | 1 |
| Kikuchi, T; Kimura, T; Kobayashi, I; Kondo, Y; Kuwabara, A; Okajima, F; Sho, K; Tomura, H | 1 |
| Gill, ZP; Holly, JM; Newcomb, PV; Perks, CM | 2 |
| Fu, W; Furukawa, K; Goodman, Y; Luo, H; Mattson, MP | 1 |
| Bielawska, AE; Hannun, YA; Jiang, L; Melkonyan, HS; Piot, C; Shapiro, JP; Tomei, LD; Umansky, SR; Wolfe, CL | 1 |
| Berthier, F; Kushner, I; Lozanski, G | 1 |
| Bergstrom, R; Jackson, J; Meisinger, J; Metz, RJ; Patel, S; Vellody, K; Wright, MA; Young, MR | 1 |
| Baker, A; Briehl, MM; Payne, CM; Powis, G | 1 |
| Cui, SH; Ito, M; Tanabe, F | 1 |
| Cuvillier, O; Rosenthal, DS; Smulson, ME; Spiegel, S | 1 |
| Cammarata, PR; Dunlap, JA; Lowe, WL; Thomas, MJ; Yorek, MA; Zhou, C | 1 |
| Burl, S; Chahine, H; Damen, J; Eaves, A; Eaves, C; Krystal, G; Liu, L; Maguer-Satta, V | 1 |
| Chatterjee, S; Diehl, AM; Lawler, JF; Roberts, E; Yin, M | 1 |
| Elo, I; Eriksson, JE; Häkkinen, L; Holmström, TH; Kähäri, VM; Reunanen, N; Westermarck, J | 1 |
| Kim, BC; Kim, JH | 1 |
| Koezuka, Y; Motoki, K; Natori, T; Sakai, T; Uchimura, A; Ueno, H | 1 |
| Gear, AR; Simon, CG | 1 |
| Hanazawa, S; Ishida, M; Kitano, S; Ozaki, K; Takeda, H; Yasuda, H | 1 |
| Borner, C; Jansen, B; Monney, L; Olivier, R; Otter, I; Poirier, GG | 1 |
| Galvan, V; Roizman, B | 1 |
| Dorrington, J; Foghi, A; Kuksis, A; Ravandi, A; Teerds, KJ; Van Der Donk, H | 1 |
| Flores, I; Hannun, YA; Martinez-A, C; Mérida, I | 1 |
| Hoekstra, D; Klappe, K; Kok, JW; Veldman, RJ | 1 |
| Banno, Y; Ito, Y; Iwasaki-Bessho, Y; Kitajima, Y; Nozawa, Y; Yoshimura, S | 1 |
| Harada-Shiba, M; Kamido, H; Kinoshita, M; Shimokado, K | 1 |
| Kasahara, M; Kishida, E; Masuzawa, Y; Yano, M | 1 |
| Hashizume, T; Kageura, T; Sato, T | 1 |
| Ballou, LR; Kanekura, T; Kirtikara, K; Laulederkind, SJ; Raghow, R | 1 |
| Chen, CW; Cheng, AL; Chuang, SE; Jee, SH; Kuo, ML | 1 |
| Brachet, P; Canova, C; Chevalier, G; Remy, S; Wion, D | 1 |
| Belloc, F; Bernard, P; Boisseau, MR; Chabrol, J; Dachary-Prigent, J; Dumain, P; Durrieu, F; Lacombe, F; Lacoste, L; Morjani, H; Reiffers, J | 1 |
| Abe, K; Aoyagi, T; Eguchi, K; Ichinose, Y; Kawabe, Y; Koji, T; Migita, K; Nagataki, S; Nakamura, H; Tsukada, T | 1 |
| Boland, MP; O'Neill, LA | 1 |
| Birnbaum, MJ; Pittman, RN; Summers, SA; Zhou, H | 1 |
| He, H; Hershberger, PA; McCarthy, SA | 1 |
| Bilney, AJ; Hartfield, PJ; Murray, AW | 1 |
| Card, GL; Pfau, JC; Walker, EB | 1 |
| Jin, JS; Johns, DG; Webb, RC | 1 |
| Bigl, V; Perez-Polo, JR; Rossner, S; Schliebs, R; Ueberham, U | 1 |
| Berg, KA; Kaga, S; Ochi, A; Ragg, SJ | 1 |
| Galadari, S; Hannun, YA; Kamibayashi, C; Kishikawa, K; Mumby, MC | 1 |
| Bezombes, C; de Mas-Mansat, V; Jaffrézou, JP; Laurent, G; Levade, T; Maestre, N | 1 |
| Birnbaum, MJ; Garza, LA; Summers, SA; Zhou, H | 1 |
| Driscoll, TA; Hannun, YA; Obeid, LM; Zhang, J | 1 |
| Patel, M | 1 |
| Lakics, V; Vogel, SN | 1 |
| Hama-Inaba, H; Matsushima, T; Mori, M; Muto, M; Ohyama, H; Saitoh, T; Takusagawa, M; Wang, B; Yamada, T | 1 |
| Bártová, E; Bobková, M; Janáková, L; Rittich, B; Spanová, A | 1 |
| Dorrington, JH; Foghi, A; Ghahremani, M | 1 |
| Carabillò, M; Di Liberto, D; Giuliano, M; Lauricella, M; Tesoriere, G; Vento, R | 1 |
| Inokuchi, J; Kuriyama, M; Mutoh, T; Tokuda, A | 1 |
| Bitar, KN; Ibitayo, AI; Nozu, F; Owyang, C; Tsunoda, Y | 1 |
| Csaba, G; Kovács, P; Müller, WE | 1 |
| Andrieu-Abadie, N; Brossmer, R; Caspar-Bauguil, S; Escargueil-Blanc, I; Levade, T; Nègre-Salvayre, A; Salvayre, R | 1 |
| Barnett, T; Birt, DF; Enkvetchakul, B; Geisler, V; Liotta, DC; Menaldino, DS; Merrill, AH; Pour, PM; Schwartzbauer, J | 1 |
| Badwey, JA; Huang, R; Lian, JP; Robinson, D | 1 |
| Kohsaka, H; Miyasaka, N; Mizushima, N | 1 |
| Hirabayashi, Y; Inokuchi, J; Ito, M; Ji, L; Yamagata, T; Zhang, G | 1 |
| Ammon, HP; Cartus, T; Drews, G; Heurich, RO | 1 |
| Kurokawa, Y; Shimeno, H; Soeda, S; Tsunoda, T | 1 |
| Barter, PJ; Bert, AG; Cockerill, P; Gamble, JR; Hii, CS; Khew-Goodall, Y; Rye, KA; Vadas, MA; Wang, L; Xia, P | 1 |
| Bitar, KN; Wang, P | 1 |
| Altura, BM; Altura, BT; Li, W; Zheng, T | 1 |
| Duronio, V; Foltz, IN; Scheid, MP; Schrader, JW; Young, PR | 1 |
| Carabillò, M; Emanuele, S; Giuliano, M; Lauricella, M; Tesoriere, G; Vento, R | 1 |
| DeFranco, AL; MacKichan, ML | 1 |
| Clift, RE; Reiners, JJ | 1 |
| Hatch, GM; Kelly, SL; Xu, FY | 1 |
| Désilets, M; Soboloff, J; Sorisky, A; Tsang, BK | 1 |
| Centeno, F; Claro, E; Fuentes, JM; Mora, A; Soler, G | 1 |
| Kikuchi, S; Moriwaka, F; Shinpo, K; Tashiro, K | 1 |
| Blanco, JC; Medvedev, AE; Qureshi, N; Vogel, SN | 1 |
| Downs, S; Ghosh, S; Hupke, M; Mahajan, S; Sudbeck, EA; Uckun, FM; Zheng, Y | 1 |
| Barker, PA; MacPhee, I | 1 |
| Blázquez, C; Daza, A; Galve-Roperh, I; Guzmán, M; Sánchez, C | 1 |
| Csaba, G; Hegyesi, H; Köhidai, L; Kovács, P; Nemes, P | 1 |
| Boustany, RM; Guo, WX; Nikbakht, K; Puranam, KL; Qian, WH | 1 |
| Bitar, KN; Ibitayo, A; Su, X; Wang, P | 1 |
| Couch, LH; Domon, O; Howard, PC; Jenkins, GR; McGarrity, LJ; Melchior, WB; Morris, SM; Muskhelishvili, L; Muskhelishvili, M; Tolleson, WH | 1 |
| Alesse, E; Angelucci, A; Di Marcotullio, L; Giannini, G; Gulino, A; Zazzeroni, F | 1 |
| Lee, BR; Um, HD | 1 |
| Cifone, MG; Debatin, KM; Herr, I; Kurz, E; Martin-Villalba, A; Roncaioli, P; Schenkel, J | 1 |
| Downward, J; Watton, SJ | 1 |
| Bravery, CA; Hoffbrand, AV; Lewin, J; Mehta, AB; Mengubas, K; Owens, DL; Riordan, FA; Wickremasinghe, RG | 1 |
| Kim, SS; Kim, YH | 1 |
| Fahey, AA; Hoffbrand, AV; Lewin, J; Mehta, AB; Mengubas, K; Wickremasinghe, RG | 1 |
| Asahara, H; Kira, J; Ohyagi, Y; Taniwaki, T; Yamada, T | 1 |
| Koizumi, M; Masamune, A; Masamune, O; Mukaida, N; Shimosegawa, T; Toyota, T | 1 |
| Aalame, N; Bodis, S; Glanzmann, C; Pruschy, M; Resch, H; Shi, YQ | 1 |
| Akimoto, S; Fujino, MA; Hisano, N; Mitsumata, M; Ozaki, Y; Satoh, K; Yatomi, Y | 1 |
| Campbell, WB; Li, PL; Zhang, DX; Zou, AP | 1 |
| Dickens, M; Holly, JM; Newcomb, PV; Savage, PB; Stewart, CE; Tavare, J | 1 |
| Czaja, MJ; Jones, BE; Lo, CR; Srinivasan, A; Valentino, KL | 1 |
| Dallalio, G; Means, RT; North, M; Worden, BD | 1 |
| Kozawa, O; Shinoda, J; Tokuda, H; Uematsu, T | 1 |
| Bernard, P; Bobichon, H; Buisson-Legendre, N; Emonard, H; Haye, B; Hornebeck, W; Maquart, FX; Schneider, C | 1 |
| Brindley, DN; Hanna, AN; Mei, J; Wang, CN; Xu, J | 1 |
| Dobashi, K; Ghosh, B; Pahan, K; Singh, I | 1 |
| Banno, Y; Hayashi, K; Nakashima, S; Nozawa, Y; Sakai, N; Sawada, M; Yamakawa, H; Yoshimura, S | 1 |
| Korsmeyer, SJ; Krammer, PH; Peter, ME; Scaffidi, C; Schmitz, I; Zha, J | 1 |
| Meng, YH; Mivechi, NF; Woessmann, W | 1 |
| Gill, ZP; Holly, JM; Maile, LA; Perks, CM | 1 |
| Belaud-Rotureau, MA; Belloc, F; Bernard, P; Durrieu, F; Lacombe, F; Lacoste, L; Vial, JP | 1 |
| Askew, DJ; Brunner, T; Green, DR; Kuscuoglu, U; Miesfeld, RL | 1 |
| Carlberg, C; Colston, KW; Danielsson, C; James, SY; Pirianov, G | 1 |
| Cuvillier, O; Edsall, L; Kohama, T; Nava, V; Olivera, A; Poulton, S; Spiegel, S | 1 |
| Han, JS; Jung, PM; Kim, JH; Park, BJ | 1 |
| Abe, A; Shayman, JA | 1 |
| Díaz-Laviada, I; Miguel, A; Ruiz, L | 1 |
| Loh, TT; Sheng, HP; Zhang, QH | 1 |
| Christensen, RA; de Aos Scherpenseel, I; Fujikawa, K; Jain, SK; Presman, E; Varticovski, L | 1 |
| Ito, A; Nomura, Y; Okuma, Y; Tokumitsu, A; Uehara, T | 1 |
| Handa, S; Ogura, M | 1 |
| Blöchl, A; Heumann, R; Susen, K | 1 |
| Bokoch, GM; Mooney, AF; Reed, JC; Sanders, LC; Schürmann, A; Sells, MA; Wang, HG | 1 |
| Abend, M; Frombeck, S; Van Beuningen, D | 1 |
| Bonnet, J; de Nanteuil, G; Léonce, S; Lesur, C; Pérez, V; Rolland, G; Sabatini, M; Thomas, M | 1 |
| Cook, WJ; McDonald, JM; Micoli, KJ; Pan, G; Williams, JP; Wu, Y | 1 |
| Allan, D | 1 |
| Ginis, I; Hallenbeck, JM; Liu, J; Spatz, M | 1 |
| Craighead, M; Pole, J; Waters, C | 1 |
| Colburn, NH; Collins, K; Davis, MA; Flaws, JA; Young, M | 1 |
| Brown, AM; Kristal, BS | 1 |
| Alvarez, A; Cuadrado, A; López-Valdaliso, R; Martín, D; Salinas, M | 1 |
| Mori, M; Tsushima, H | 1 |
| Farndon, JR; Lai, T; Mihai, R; Schofield, G | 1 |
| Aoyagi, T; Eguchi, K; Fukuda, T; Hirai, Y; Honda, S; Ida, H; Kawabe, Y; Kawakami, A; Kita, M; Migita, K; Tsukada, T; Yamasaki, S | 1 |
| Cortés, ML; Galve-Roperh, I; Gómez del Pulgar, T; Guzmán, M; Izquierdo, M; Sánchez, C | 1 |
| Lobner, D | 1 |
| Domae, N; Kondo, T; Matsuda, T; Okazaki, T; Tashima, M; Uchiyama, T; Umehara, H; Yokoyama, K | 1 |
| Baile, CA; Compton, MM; Dean, RG; Hartzell, DL; Hausman, DB; Hausman, GJ; Kim, HS; Martin, RJ | 1 |
| Cho, S; Dawson, G | 1 |
| Chan, C; Goldkorn, T | 1 |
| Albar, JP; Brás, A; de Buitrago, GG; Leonardo, E; Martínez-A, C | 1 |
| Ahmed, N; Berridge, MV | 1 |
| Gendelman, HE; Kaul, M; Lipton, SA; Nottet, HS; Thylin, M; Yeh, MW; Zheng, J | 1 |
| Clementi, E; De Nadai, C; Manfredi, AA; Paolucci, C; Rovere, P | 1 |
| Abe, T; Tamai, M; Tomita, H | 1 |
| Li, Y; Takao, N; Yamamoto, K | 1 |
| Barsacchi, R; Cantoni, O; Clementi, E; De Nadai, C; Lièvremont, JP; Meldolesi, J; Moncada, S; Sciorati, C; Sestili, P | 1 |
| Holly, JM; Meadows, KA; Stewart, CE | 1 |
| Bektas, M; Daniel, P; Eberle, J; Geilen, CC; Orfanos, CE; Raisova, M; Wieder, T | 1 |
| Colombaioni, L; Garcia-Gil, M; Tavarini, S | 1 |
| Chik, CL; Ho, AK; Karpinski, E; Li, B; Negishi, T | 1 |
| English, BK; Knapp, KM | 1 |
| Enomoto, A; Hirano, K; Koyama, H; Matsumoto, Y; Morita, A; Sakai, K; Suzuki, N | 1 |
| Azuma, T; Bierer, BE; Kwiatkowski, DJ; Martelli, MP; Posey, SC | 1 |
| Campbell, V; Lynch, MA | 1 |
| Alessio, M; Bonissoni, S; Brusco, A; Dianzani, I; Dianzani, U; Difranco, D; Franzese, A; Matrecano, E; Pignata, C; Ramenghi, U | 1 |
| O'Byrne, D; Sansom, D | 1 |
| Allan, D; Shawyer, A; Taylor, A | 1 |
| Channing, DR; Nahorski, SR; Young, KW | 1 |
| Fukunaga, T; Hatsuzawa, K; Nagahama, M; Tagaya, M; Tani, K; Yamamoto, A | 1 |
| Hong, X; Hu, J; Jiang, Z; Long, H; Zhai, Z | 1 |
| Benassi, L; Cossarizza, A; Di Nardo, A; Giannetti, A; Magnoni, C; Seidenari, S | 1 |
| Dietrich, J; Geisler, C; Kastrup, J; Lauritsen, JP; Menné, C; Odum, N; Wegener, AM | 1 |
| Agid, Y; Darios, F; Hirsch, EC; Lambeng, N; Michel, PP; Muriel, MP; Ruberg, M | 1 |
| Pahlavani, MA; Vargas, DM | 1 |
| Hirokawa, M; Kitabayashi, A; Kuroki, J; Miura, AB | 1 |
| Geilen, CC; Müller-Wieprecht, V; Orfanos, CE; Riebeling, C; Stooss, A | 1 |
| Béréziat, G; Klapisz, E; Koumanov, KS; Masliah, J; Wolf, C | 1 |
| Colombini, M; Siskind, LJ | 1 |
| Nagayama, Y; Namba, H; Ohtsuru, A; Sautin, Y; Shklyaev, S; Takamura, N; Yamashita, S | 1 |
| Benito, M; Lorenzo, M; Navarro, P; Rohn, JL; Valverde, AM | 1 |
| Campo, ML; Claro, E; Ramos, B; Salido, GM | 1 |
| Li, XM; Meinkoth, J; Pittman, RN; Zhou, H | 1 |
| Chai, MQ; Chen, HH; Chen, JS; Song, JG; Zhao, S | 1 |
| Cheng, S; Mao, J; Rehder, V | 1 |
| Kihara, T; Kimura, M; Ochiai, T; Oda, M; Ono, N; Shimeno, H; Soeda, S | 1 |
| Hozumi, Y; Katagata, Y; Kondo, S; Maeshima, H; Mitsuhashi, Y; Sugiki, H | 1 |
| Chen, Y; Ginis, I; Hallenbeck, JM | 1 |
| Han, J; Shin, I | 1 |
| Gerst, JE; Marash, M | 1 |
| Koch, B; Loeffler, JP; Sée, V | 1 |
| Lai, MT; Vlahos, CJ; Zinda, MJ | 1 |
| Andersen, PS; Dietrich, J; Geisler, C; Kastrup, J; Lauritsen, JP; Menné, C; Odum, N; Wegener, AK | 1 |
| Burrows, J; Connor, CE; Hearps, AC; Lowenthal, RM; Ragg, SJ; Woods, GM | 2 |
| DeWald, DB; Stratford, S; Summers, SA | 1 |
| Chang, YJ; Chen, CC; Chen, JJ; Sun, YT | 1 |
| Cho, ES; Kim, DK; Lee, BR; Um, HD | 1 |
| Hiraishi, H; Shimada, T; Terano, A | 1 |
| Bielawska, A; Clavien, PA; Hannun, YA; Morse, MA; Rüdiger, HA; Selzner, M; Sindram, D | 1 |
| Cuvillier, O; Edsall, LC; Milstien, S; Spiegel, S; Twitty, S | 1 |
| Kajimoto, T; Ohmori, S; Saito, N; Sakai, N; Shirai, Y | 1 |
| Fornace, AJ; Hollander, MC; Iglesias, M; Sheikh, MS; Woodworth, C; Yu, K; Zhan, Q | 1 |
| Balendran, A; Batty, IH; Blair, AS; Downes, CP; Hajduch, E; Hundal, HS; Litherland, GJ | 1 |
| Fabregat, I; Frago, LM; Pañeda, C; Varela-Nieto, I | 1 |
| Axel, DI; Karsch, KR; Mayer, P; Shook, KS; Spyridopoulos, I; Viebahn, R | 1 |
| Bode, AM; Castranova, V; Ding, M; Dong, Z; Huang, C; Li, J; Ma, WY; Shi, X; Vallyathan, V | 1 |
| Chen, Y; Furuya, K; Ginis, I; Hallenbeck, JM; Takeda, H | 1 |
| Cho, KH; Chung, JH; Kim, DS; Kim, KH; Kim, SY; Moon, SJ; Park, KC | 1 |
| Chi, KH; Hsu, YW; Huang, WC; Lin, WW | 1 |
| Li, PL; Zhang, DX; Zou, AP | 1 |
| Bader, MF; Caumont, AS; Chasserot-Golaz, S; Du, G; Frohman, MA; Morris, AJ; Sciorra, VA; Vitale, N; Wu, S | 1 |
| Bonnet, J; de Nanteuil, G; Deschamps, C; Lesur, C; Rolland, G; Sabatini, M; Thomas, M | 1 |
| Belichenko, I; Morishima, N; Separovic, D | 1 |
| Choi, MR; Suh, HW; Won, JS | 1 |
| Di Virgilio, F; Ferrari, D; Pinton, P; Pozzan, T; Rapizzi, E; Rizzuto, R | 1 |
| Beckett, MA; Gupta, N; Khodarev, NN; Khorasani, L; Kufe, DW; Nodzenski, E; Weichselbaum, RR; Yu, J | 1 |
| Brugg, B; Caboche, J; Lemaigre-Dubreuil, Y; Mariani, J; Vanhoutte, P; Willaime, S | 1 |
| Adzet, T; Alegret, M; Cabrero, A; Laguna, JC; Sánchez, R; Vázquez, M | 1 |
| Hajnóczky, G; Pacher, P | 1 |
| Abboud, HE; Ghosh Choudhury, G; Ghosh-Choudhury, N; Zhang, JH | 1 |
| Gulbins, E; Roth, W; Wagenknecht, B; Weller, M; Wolburg, H | 1 |
| Bourgoin, SG; Brindley, DN; Morris, AJ; Sciorra, VA; Singh, IN; Stromberg, LM | 1 |
| Dillehay, DL; Kustin, EM; Lemonnier, LA; Merrill, AH; Roberts, PC; Schmelz, EM; Sullards, MC | 1 |
| Inn-Oc, H; Joe, E; Jou, I; Yang, MS | 1 |
| Cho, S; Dawson, G; Dawson, PE | 1 |
| Bersacchi, R; Cantoni, O; Clementi, E; De Nadai, C; Guidarelli, A | 1 |
| Begg, D; Berthiaume, LG; Bourgoin, S; Brindley, DN; Hanna, AN; Kikuchi, Y | 1 |
| Budagian, V; Bulanova, E; Bulfone-Paus, S; Dürkop, H; Krause, H; Paus, R; Pohl, T | 1 |
| Bourbon, NA; Kester, M; Sandirasegarane, L | 1 |
| Cho, ES; Kim, DK; Seong, JK; Um, HD | 1 |
| Elmendorf, JS; Kralik, SF; Leffler, BJ; Liu, P | 1 |
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2 review(s) available for n-acetylsphingosine and sphingosine
| Article | Year |
|---|---|
A turn in the road: How studies on the pharmacology of glucosylceramide synthase inhibitors led to the identification of a lysosomal phospholipase A2 with ceramide transacylase activity.
Topics: Acylation; Acyltransferases; Animals; Cattle; Ceramides; DNA, Complementary; Enzyme Inhibitors; Glucosyltransferases; Humans; Lysosomes; Mice; Molecular Structure; Morpholines; Phospholipases A; Phospholipases A2; Signal Transduction; Sphingosine | 2004 |
Novelty of Sphingolipids in the Central Nervous System Physiology and Disease: Focusing on the Sphingolipid Hypothesis of Neuroinflammation and Neurodegeneration.
Topics: Alzheimer Disease; Central Nervous System; Ceramides; Eicosanoids; Forecasting; Homeostasis; Humans; Inflammation; Lipoxygenase; Lysophospholipids; Membrane Lipids; Models, Biological; Nerve Degeneration; Neurodegenerative Diseases; Neuroglia; Neurons; Parkinson Disease; Phosphotransferases (Alcohol Group Acceptor); Prostaglandin-Endoperoxide Synthases; Sphingolipids; Sphingosine | 2021 |
484 other study(ies) available for n-acetylsphingosine and sphingosine
| Article | Year |
|---|---|
New ceramide from marine sponge Haliclona koremella and related compounds as antifouling substances against macroalgae.
Topics: Animals; Ceramides; Eukaryota; Magnetic Resonance Spectroscopy; Mass Spectrometry; Porifera; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 1998 |
Effects of stereochemistry, saturation, and hydrocarbon chain length on the ability of synthetic constrained azacyclic sphingolipids to trigger nutrient transporter down-regulation, vacuolation, and cell death.
Topics: Animals; Cell Death; Down-Regulation; Humans; Hydrocarbons; Membrane Transport Proteins; Sphingolipids; Stereoisomerism; Structure-Activity Relationship; Vacuoles | 2016 |
Regulation of phospholipase D by sphingosine involves both protein kinase C-dependent and -independent mechanisms in NIH 3T3 fibroblasts.
Topics: 3T3 Cells; Alkaloids; Animals; Bryostatins; Down-Regulation; Drug Interactions; Ethers, Cyclic; Hydrolysis; Lactones; Macrolides; Mice; Okadaic Acid; Phosphatidylethanolamines; Phospholipase D; Phospholipids; Platelet-Derived Growth Factor; Protein Kinase C; Sphingomyelin Phosphodiesterase; Sphingosine; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1992 |
Metabolism of semisynthetic single-chain GM1 derivatives in cerebellar granule cells in culture.
Topics: Animals; Carbohydrate Sequence; Cells, Cultured; Cerebellum; G(M1) Ganglioside; Molecular Sequence Data; Rats; Sphingosine | 1991 |
The differential influence of protein kinase inhibitors on retinal arbor morphology and eye-specific stripes in the frog retinotectal system.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Horseradish Peroxidase; Isoquinolines; Nerve Tissue Proteins; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Piperazines; Polyvinyls; Protein Kinase Inhibitors; Rana pipiens; Retina; Retinal Ganglion Cells; Sphingosine; Superior Colliculi; Visual Pathways | 1990 |
Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells.
Topics: Antigens, Surface; Apoptosis; Base Sequence; bcl-X Protein; Breast Neoplasms; Cell Division; Ceramides; Dexamethasone; Drug Resistance; Enzyme Activation; fas Receptor; Female; Humans; Luciferases; Molecular Sequence Data; NF-kappa B; Phospholipases A; Phospholipases A2; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Quinacrine; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1995 |
Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells.
Topics: Apoptosis; Base Sequence; Curcumin; DNA, Neoplasm; Gene Expression; Genes, jun; Humans; Leukemia; Molecular Sequence Data; Oligonucleotides, Antisense; Proto-Oncogene Proteins c-jun; RNA, Messenger; Signal Transduction; Sphingosine; Transcription Factor AP-1; Tumor Cells, Cultured | 1995 |
Effects of sphingosine derivatives on MC3T3-E1 pre-osteoblasts: psychosine elicits release of calcium from intracellualr stores.
Topics: 3T3 Cells; Animals; Calcium; Fluorescent Dyes; Fura-2; Kinetics; Lysophospholipids; Mice; Osteoblasts; Phosphorylation; Phosphorylcholine; Psychosine; Sphingosine; Structure-Activity Relationship | 1995 |
Inhibition of acyl-CoA:cholesterol acyltransferase in Chinese hamster ovary (CHO) cells by short-chain ceramide and dihydroceramide.
Topics: Animals; Ceramides; CHO Cells; Cholesterol; Cricetinae; Esterification; Hydroxycholesterols; Kinetics; Lipoproteins, LDL; Sphingosine; Sterol O-Acyltransferase | 1995 |
The dimeric and catalytic subunit forms of protein phosphatase 2A from rat brain are stimulated by C2-ceramide.
Topics: Animals; Antibody Specificity; Binding Sites; Brain; Catalysis; Dose-Response Relationship, Drug; Enzyme Activation; Isoenzymes; Male; Phosphoprotein Phosphatases; Protein Conformation; Protein Phosphatase 2; Rats; Second Messenger Systems; Sphingosine | 1995 |
Preferential inhibition of phorbol ester-induced hydrolysis of phosphatidylethanolamine by N-acetylsphingosine in NIH 3T3 fibroblasts.
Topics: 3T3 Cells; Animals; Carbon Radioisotopes; Fibroblasts; Hydrolysis; Indoles; Kinetics; Maleimides; Mice; Palmitic Acid; Palmitic Acids; Phosphatidylethanolamines; Phospholipase D; Protein Kinase C; Radioisotope Dilution Technique; Rats; Sphingosine; Tetradecanoylphorbol Acetate | 1995 |
N-acetylsphingosine (C2-ceramide) inhibited neutrophil superoxide formation and calcium influx.
Topics: Alkaloids; Biological Transport, Active; Blood Proteins; Calcium; Enzyme Activation; Humans; In Vitro Techniques; Kinetics; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Spectrometry, Fluorescence; Sphingosine; Staurosporine; Superoxides | 1995 |
Evidence that ceramide selectively inhibits protein kinase C-alpha translocation and modulates bradykinin activation of phospholipase D.
Topics: Animals; Blotting, Western; Bradykinin; Cell Line; Ceramides; Enzyme Activation; Epidermis; Fibroblasts; Humans; Inositol Phosphates; Isoenzymes; Kinetics; Mice; Phospholipase D; Protein Kinase C; Skin; Sphingomyelin Phosphodiesterase; Sphingosine; Time Factors | 1995 |
Utilization of exogenously supplied sphingosine analogues for sphingolipid biosynthesis in Chinese hamster ovary and mouse LM cell fibroblasts.
Topics: Acetates; Acetic Acid; Animals; Carbon Radioisotopes; Cell Division; CHO Cells; Choline; Cricetinae; Kinetics; L Cells; Mice; Palmitic Acid; Palmitic Acids; Phospholipids; Radioisotope Dilution Technique; Serine; Sphingolipids; Sphingomyelins; Sphingosine; Tritium | 1993 |
Biosynthesis of N-acetylsphingosine by platelet-activating factor: sphingosine CoA-independent transacetylase in HL-60 cels.
Topics: Acetyltransferases; Binding, Competitive; Chromatography, Thin Layer; Diethyl Pyrocarbonate; Enzyme Inhibitors; Ethylmaleimide; HL-60 Cells; Humans; Lung; Platelet Activating Factor; Sphingosine; Stereoisomerism; Substrate Specificity | 1996 |
Fas ligation induces apoptosis and Jun kinase activation independently of CD45 and Lck in human T cells.
Topics: Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; fas Receptor; Humans; JNK Mitogen-Activated Protein Kinases; Leukemia-Lymphoma, Adult T-Cell; Leukocyte Common Antigens; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-jun; Signal Transduction; Sorbitol; Sphingosine; src-Family Kinases; T-Lymphocytes; Tumor Cells, Cultured | 1996 |
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.
Topics: Animals; Apoptosis; Cattle; Cell Line; Ceramides; Enzyme Activation; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutation; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-jun; Signal Transduction; Sphingosine; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1996 |
A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae.
Topics: Apoptosis; Cell Cycle; Cell Division; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Flow Cytometry; Fungal Proteins; G1 Phase; Genes, Fungal; Membrane Proteins; Mutation; Phosphoprotein Phosphatases; Saccharomyces cerevisiae; Signal Transduction; Sphingosine | 1996 |
Interleukin-1 beta-induced ceramide and diacylglycerol generation may lead to activation of the c-Jun NH2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5F.
Topics: Activating Transcription Factor 2; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Ceramides; Cyclic AMP Response Element-Binding Protein; Diglycerides; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Insulin; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Leucine Zippers; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Nitric Oxide Synthase; Okadaic Acid; Oligonucleotides; Proto-Oncogene Proteins c-jun; Rats; Receptors, Interleukin-1; Signal Transduction; Sphingomyelins; Sphingosine; Transcription Factors; Type C Phospholipases | 1996 |
Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway.
Topics: Alkaloids; Animals; Apoptosis; Cells, Cultured; Ceramides; Chick Embryo; DNA Damage; Enzyme Inhibitors; Neurons; Protein Kinase C; Sphingomyelins; Sphingosine; Staurosporine; Time Factors | 1996 |
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate.
Topics: 3T3 Cells; Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Ceramides; DNA Damage; Enzyme Activation; fas Receptor; HL-60 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Lysophospholipids; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitosis; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Signal Transduction; Sphingosine; Tumor Necrosis Factor-alpha | 1996 |
A novel enzyme that catalyzes the esterification of N-acetylsphingosine. Metabolism of C2-ceramides.
Topics: Acyltransferases; Animals; Catalysis; Cell Line; Ceramides; Dogs; Esters; Kidney; Kinetics; Liposomes; Mice; Sphingosine; Substrate Specificity | 1996 |
Tumor necrosis factor-alpha and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles.
Topics: Animals; Apoptosis; Cells, Cultured; Ceramides; Diethylstilbestrol; DNA; Drug Implants; Female; Follicle Stimulating Hormone; Gold Sodium Thiomalate; Humans; Mice; Ovarian Follicle; Progesterone; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Second Messenger Systems; Sphingosine; Tumor Necrosis Factor-alpha | 1996 |
Ceramide induces apoptosis via CPP32 activation.
Topics: Apoptosis; Caspase 1; Caspase 3; Caspases; Ceramides; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme Precursors; Humans; Jurkat Cells; Kinetics; Oligopeptides; Protease Inhibitors; Sphingosine | 1996 |
Cross-talk between ceramide and PKC activity in the control of apoptosis in WEHI-231.
Topics: Alkaloids; Animals; Apoptosis; Benzophenanthridines; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Lymphoma, B-Cell; Mice; Naphthalenes; Phenanthridines; Protein Kinase C; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Tumor Cells, Cultured | 1996 |
Cell-permeable ceramide inhibits the growth of B lymphoma Raji cells lacking TNF-alpha-receptors by inducing G0/G1 arrest but not apoptosis: a new model for dissecting cell-cycle arrest and apoptosis.
Topics: Apoptosis; Cell Division; Cell Membrane Permeability; Drug Resistance, Neoplasm; Enzyme Inhibitors; G1 Phase; HL-60 Cells; Humans; Immunoblotting; Lymphoma, B-Cell; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Receptors, Tumor Necrosis Factor; Resting Phase, Cell Cycle; Retinoblastoma Protein; Sphingosine; Tumor Necrosis Factor-alpha | 1996 |
Sphingosine-induced inhibition of capacitative calcium influx in CFPAC-1 cells.
Topics: Adenocarcinoma; Biological Transport; Calcium; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Humans; Manganese; Membrane Potentials; Mitochondria; Oligomycins; Pancreatic Ducts; Pancreatic Neoplasms; Propidium; Rhodamine 123; Rhodamines; Rotenone; Sphingosine; Thapsigargin; Tumor Cells, Cultured; Uncoupling Agents; Uridine Diphosphate | 1996 |
Ceramide inhibits IgG-dependent phagocytosis in human polymorphonuclear leukocytes.
Topics: Ceramides; Chemotaxis, Leukocyte; Erythrocytes; Glycerophospholipids; Humans; Immunoglobulin G; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phagocytosis; Phosphatidic Acids; Sphingomyelin Phosphodiesterase; Sphingosine; Time Factors | 1997 |
Loss of ceramide production confers resistance to radiation-induced apoptosis.
Topics: Alkaloids; Amidohydrolases; Animals; Apoptosis; Benzophenanthridines; Cell Division; Cell Nucleus; Cell Survival; Cells, Cultured; Ceramidases; Ceramides; Dose-Response Relationship, Radiation; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Lymphocytes; Mice; Oleic Acids; Phenanthridines; Sphingosine; Time Factors | 1997 |
Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione.
Topics: Animals; Cells, Cultured; Ceramides; Diglycerides; Dose-Response Relationship, Drug; Electron Transport; Glutathione; Hydrogen Peroxide; Liver; Mitochondria, Liver; Permeability; Rats; Reactive Oxygen Species; Second Messenger Systems; Sphingolipids; Sphingosine; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 1997 |
Activation of CPP32 during apoptosis of neurons and astrocytes.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Astrocytes; Bisbenzimidazole; Caspase 3; Caspases; Cell-Free System; Cells, Cultured; Culture Media, Serum-Free; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Mice; Mice, Inbred Strains; Neurons; Poly(ADP-ribose) Polymerases; Sphingosine; Staurosporine | 1997 |
Induction of oligodendrocyte apoptosis by C2-ceramide.
Topics: Animals; Apoptosis; Brain; Cattle; Cells, Cultured; Diglycerides; DNA Fragmentation; Kinetics; Microscopy, Electron; Oligodendroglia; Phospholipases A; Sphingomyelin Phosphodiesterase; Sphingosine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1997 |
Ceramide generation in response to photodynamic treatment of L5178Y mouse lymphoma cells.
Topics: Animals; Apoptosis; Ceramides; DNA Fragmentation; Leukemia L5178; Mice; Photochemotherapy; Sphingosine; Time Factors | 1997 |
Sphingosine induces apoptosis in androgen-independent human prostatic carcinoma DU-145 cells by suppression of bcl-X(L) gene expression.
Topics: Androgens; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Carcinoma; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; Male; Prostatic Neoplasms; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Sphingosine; Staurosporine | 1997 |
C2-ceramide and C6-ceramide inhibited priming for enhanced release of superoxide in monocytes, but had no effect on the killing of leukaemic cells by monocytes.
Topics: Ceramides; Cytotoxicity, Immunologic; Humans; Interferon-gamma; Interleukin-1; Leukemia; Lipopolysaccharides; Monocytes; Sphingosine; Superoxides; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1997 |
Inhibitory action of sphingosine or ceramide on amylase secretion from isolated rat pancreatic acini.
Topics: Amylases; Animals; Calcimycin; Carbachol; In Vitro Techniques; Male; Pancreas; Rats; Rats, Wistar; Sincalide; Sodium Fluoride; Sphingosine; Tetradecanoylphorbol Acetate | 1997 |
Ceramide-mediated and isoquinolinesulfonamide-sensitive pathways of neuronal death: anything in common?
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Death; Cells, Cultured; Enzyme Inhibitors; Isoquinolines; Neurons; Rats; Sphingosine; Sulfonamides | 1997 |
Regulation of lipid signaling pathways for cell survival and apoptosis by bcl-2 in prostate carcinoma cells.
Topics: Animals; Apoptosis; Arachidonic Acid; Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Humans; Hydroxyeicosatetraenoic Acids; JNK Mitogen-Activated Protein Kinases; Lipid Metabolism; Male; Mitogen-Activated Protein Kinases; Naphthalenes; Prostatic Neoplasms; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Rats; Signal Transduction; Sphingosine; Transfection; Tumor Cells, Cultured | 1997 |
Bcl-2 antagonizes apoptotic cell death induced by two new ceramide analogues.
Topics: Amides; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Survival; Ceramides; Etoposide; Genes, bcl-2; Humans; Molecular Structure; Poly(ADP-ribose) Polymerases; Sphingosine; Transfection; Trypan Blue; Tumor Cells, Cultured | 1997 |
Induction of apoptosis and potentiation of TNF- and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609.
Topics: Antibodies, Monoclonal; Antigens, CD; Antineoplastic Agents; Apoptosis; Arachidonic Acid; Bridged-Ring Compounds; Chromatin; Culture Media, Serum-Free; DNA Fragmentation; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; fas Receptor; Humans; Kinetics; Leukemia, Myeloid; Norbornanes; Nucleosomes; Recombinant Proteins; Sphingomyelin Phosphodiesterase; Sphingosine; Tetradecanoylphorbol Acetate; Thiocarbamates; Thiones; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1997 |
Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I.
Topics: Actins; Animals; Apoptosis; Calpain; Cell Differentiation; Cell Survival; Ceramides; Enzyme Inhibitors; Kinetics; PC12 Cells; Rats; Sphingosine; tau Proteins; Tubulin | 1997 |
Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide.
Topics: Animals; Biological Transport; Cell Membrane Permeability; Electron Transport; Electron Transport Complex III; Glutamic Acid; HL-60 Cells; Humans; Mitochondria, Heart; Mitochondria, Muscle; Oxidative Phosphorylation; Rats; Sphingosine; Tumor Necrosis Factor-alpha | 1997 |
Tumor necrosis factor-alpha autoregulates interleukin-6 synthesis via activation of protein kinase C. Function of sphingosine 1-phosphate and phosphatidylcholine-specific phospholipase C.
Topics: 3T3 Cells; Animals; Bridged-Ring Compounds; Choline; Diglycerides; Enzyme Activation; Homeostasis; Inositol Phosphates; Interleukin-6; Kinetics; Lysophospholipids; Mice; Norbornanes; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Phosphorylcholine; Protein Kinase C; Sphingosine; Thiocarbamates; Thiones; Tumor Necrosis Factor-alpha; Type C Phospholipases | 1997 |
Inhibition of TSH-induced hydrogen peroxide production by TNF-alpha through a sphingomyelinase signaling pathway.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Hydrogen Peroxide; Ionomycin; Kinetics; Sphingomyelin Phosphodiesterase; Sphingosine; Thapsigargin; Thyroid Gland; Thyrotropin; Tumor Necrosis Factor-alpha | 1997 |
Insulin-like growth factor-binding protein (IGFBP-3) predisposes breast cancer cells to programmed cell death in a non-IGF-dependent manner.
Topics: Apoptosis; Breast Neoplasms; Enzyme Inhibitors; Female; Flow Cytometry; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Signal Transduction; Sphingosine; Tumor Cells, Cultured | 1997 |
Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration.
Topics: Animals; Apoptosis; Cells, Cultured; DNA; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; Hippocampus; Lipid Peroxidation; Neurons; NF-kappa B; Nitrates; Nitrogen Compounds; Oxidants; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sphingosine; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Tyrosine; Uric Acid | 1997 |
Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion.
Topics: Animals; Apoptosis; Cells, Cultured; Ceramides; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Sprague-Dawley; Sphingosine | 1997 |
The sphingomyelin-ceramide pathway participates in cytokine regulation of C-reactive protein and serum amyloid A, but not alpha-fibrinogen.
Topics: Apolipoproteins; Bridged-Ring Compounds; C-Reactive Protein; Carcinoma, Hepatocellular; Ceramides; Fibrinogen; Humans; Interleukin-1; Interleukin-6; Norbornanes; RNA, Messenger; Serum Amyloid A Protein; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Thiocarbamates; Thiones; Tumor Cells, Cultured | 1997 |
Vitamin D3 and ceramide reduce the invasion of tumor cells through extracellular matrix components by elevating protein phosphatase-2A.
Topics: Animals; Blotting, Western; Cholecalciferol; Enzyme Activation; Extracellular Matrix; Humans; Laminin; Lung Neoplasms; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Okadaic Acid; Phosphoprotein Phosphatases; Protein Phosphatase 2; Sphingosine; Transfection; Vitronectin | 1996 |
Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo.
Topics: Animals; Apoptosis; Dexamethasone; DNA, Complementary; Enzyme Inhibitors; Humans; Mice; Mice, SCID; Neoplasm Proteins; Sphingosine; Staurosporine; Thapsigargin; Thioredoxins; Transfection; Tumor Cells, Cultured | 1997 |
Ceramide promotes calpain-mediated proteolysis of protein kinase C beta in murine polymorphonuclear leukocytes.
Topics: Animals; Calpain; Cysteine Proteinase Inhibitors; Down-Regulation; Isoenzymes; Leucine; Mice; Mice, Inbred C57BL; Neutrophils; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Sphingosine | 1998 |
Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes.
Topics: Apoptosis; Caspase 3; Caspase 6; Caspase 7; Caspases; Cysteine Endopeptidases; Enzyme Activation; fas Receptor; Humans; Jurkat Cells; Lamin Type B; Lamins; Lysophospholipids; Models, Biological; Nuclear Proteins; Poly Adenosine Diphosphate Ribose; Signal Transduction; Sphingosine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1998 |
Effect of TNF-alpha on SMIT mRNA levels and myo-inositol accumulation in cultured endothelial cells.
Topics: Animals; Aorta; Carrier Proteins; Cattle; Cells, Cultured; Cerebrovascular Circulation; Cytokines; Endothelium, Vascular; Growth Substances; Heat-Shock Proteins; Humans; Inositol; Kinetics; Membrane Proteins; Mice; Microcirculation; Pulmonary Artery; Sphingosine; Symporters; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1998 |
BCR-ABL accelerates C2-ceramide-induced apoptosis.
Topics: Apoptosis; Cell Division; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphorylation; Sphingosine; Tumor Necrosis Factor-alpha; Tyrosine | 1998 |
Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase.
Topics: Antibodies; Apoptosis; Biological Transport; CCAAT-Enhancer-Binding Proteins; Cell Nucleus; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Endopeptidases; Enzyme Activation; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation; Humans; Liver; Models, Biological; Nuclear Proteins; Protein Binding; Protein Processing, Post-Translational; Regulatory Sequences, Nucleic Acid; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Sterol Regulatory Element Binding Protein 1; Transcription Factors; Tumor Necrosis Factor-alpha | 1998 |
Enhancement of fibroblast collagenase (matrix metalloproteinase-1) gene expression by ceramide is mediated by extracellular signal-regulated and stress-activated protein kinase pathways.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Ceramides; Collagenases; Extracellular Matrix; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 1998 |
Exogenous C2-ceramide activates c-fos serum response element via Rac-dependent signalling pathway.
Topics: Animals; Arachidonic Acid; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; GTP Phosphohydrolases; GTP-Binding Proteins; Nuclear Proteins; Phospholipases A; Phospholipases A2; rac GTP-Binding Proteins; Rats; Serum Response Factor; Signal Transduction; Sphingosine; Transcription Factors; Transfection | 1998 |
Effects of alpha- and beta-galactosylated C2-ceramides on the immune system.
Topics: Adjuvants, Immunologic; Animals; Female; Galactosides; Immunosuppressive Agents; Lymphocyte Culture Test, Mixed; Lymphocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Molecular; Molecular Conformation; Molecular Structure; Sphingosine; Spleen; Structure-Activity Relationship | 1998 |
Membrane-destabilizing properties of C2-ceramide may be responsible for its ability to inhibit platelet aggregation.
Topics: Adenine; Blood Platelets; Cell Membrane Permeability; Humans; Membrane Fluidity; Microscopy, Electron, Scanning; Platelet Aggregation; Platelet Aggregation Inhibitors; Pseudopodia; Sphingosine | 1998 |
Sphingomyelinase and ceramide inhibit formation of F-actin ring in and bone resorption by rabbit mature osteoclasts.
Topics: Actins; Animals; Animals, Newborn; Apoptosis; Bone Resorption; Cells, Cultured; Enzyme Inhibitors; Lysophospholipids; Osteoclasts; Rabbits; Sphingomyelin Phosphodiesterase; Sphingosine | 1998 |
Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis.
Topics: Ammonium Chloride; Animals; Apoptosis; Brefeldin A; Caspase 3; Caspases; Cell Compartmentation; Cyclopentanes; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endosomes; Enzyme Activation; Humans; Lysosomes; Mice; Oligopeptides; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Necrosis Factor-alpha | 1998 |
Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner.
Topics: Animals; Antibodies; Apoptosis; Chlorocebus aethiops; Enzyme Inhibitors; fas Receptor; Heat Stress Disorders; HeLa Cells; Herpes Simplex; Herpesvirus 1, Human; Humans; Osmotic Pressure; Species Specificity; Sphingosine; Tumor Necrosis Factor-alpha; Vero Cells | 1998 |
Fas-induced apoptosis in rat thecal/interstitial cells signals through sphingomyelin-ceramide pathway.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Ceramides; Chromatography, High Pressure Liquid; DNA Fragmentation; fas Receptor; Female; Mass Spectrometry; Microscopy, Fluorescence; Rats; Rats, Wistar; Signal Transduction; Sphingomyelins; Sphingosine; Theca Cells | 1998 |
Dual role of ceramide in the control of apoptosis following IL-2 withdrawal.
Topics: Animals; Apoptosis; Cell Cycle; Cell Fractionation; Cell Line; Culture Media, Serum-Free; Diglycerides; Humans; Immunoblotting; Interleukin-2; Mice; Recombinant Proteins; Sphingosine; T-Lymphocytes, Cytotoxic | 1998 |
Metabolism and apoptotic properties of elevated ceramide in HT29rev cells.
Topics: Apoptosis; Ceramides; Colonic Neoplasms; DNA Fragmentation; Humans; Hydrolysis; Poly(ADP-ribose) Polymerases; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Tumor Cells, Cultured | 1998 |
Decreased phospholipase D (PLD) activity in ceramide-induced apoptosis of human keratinocyte cell line HaCaT.
Topics: Apoptosis; Cell Line; Cell Nucleus; DNA; DNA Fragmentation; Enzyme Inhibitors; Humans; Keratinocytes; Phospholipase D; Sphingosine; Staining and Labeling | 1998 |
Oxidized low density lipoprotein induces apoptosis in cultured human umbilical vein endothelial cells by common and unique mechanisms.
Topics: Antioxidants; Apoptosis; Butylated Hydroxytoluene; Catalase; Cells, Cultured; Ceramides; Cholesterol; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Enzyme Activation; Fibroblast Growth Factor 2; Humans; Kinetics; Lipoproteins, LDL; Oxidation-Reduction; Sphingosine; Sterols; Superoxide Dismutase; Umbilical Veins | 1998 |
Distinctive inhibitory activity of docosahexaenoic acid against sphingosine-induced apoptosis.
Topics: Apoptosis; Arachidonic Acid; Arachidonic Acids; Docosahexaenoic Acids; HL-60 Cells; Humans; Phospholipases A; Phospholipases A2; Second Messenger Systems; Sphingosine | 1998 |
Different effects of cell-permeable ceramide analogs on platelet activation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Blood Platelets; Calcium; Ceramides; Diglycerides; Platelet Activation; Platelet Aggregation Inhibitors; Rabbits; Sphingomyelin Phosphodiesterase; Sphingosine; Thrombin | 1998 |
An accessory role for ceramide in interleukin-1beta induced prostaglandin synthesis.
Topics: Alternative Splicing; Arachidonic Acid; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Isoenzymes; Membrane Proteins; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Sphingosine | 1998 |
Transforming growth factor beta1 attenuates ceramide-induced CPP32/Yama activation and apoptosis in human leukaemic HL-60 cells.
Topics: Apoptosis; Caspase 3; Caspases; Cell Cycle Proteins; Ceramides; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; HL-60 Cells; Humans; Microtubule-Associated Proteins; Oligopeptides; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Sphingomyelin Phosphodiesterase; Sphingosine; Transforming Growth Factor beta; Tumor Suppressor Proteins | 1997 |
Epigenetic control of programmed cell death: inhibition by 5-azacytidine of 1,25-dihydroxyvitamin D3-induced programmed cell death in C6.9 glioma cells.
Topics: Animals; Apoptosis; Azacitidine; Calcitriol; Decitabine; DNA Fragmentation; DNA Modification Methylases; Enzyme Inhibitors; Genes, myc; Glioma; Rats; Sphingosine; Tumor Cells, Cultured | 1998 |
Caspase activation is an early event in anthracycline-induced apoptosis and allows detection of apoptotic cells before they are ingested by phagocytes.
Topics: Animals; Annexin A5; Antibiotics, Antineoplastic; Apoptosis; Caspase 3; Caspases; CD36 Antigens; CHO Cells; Coumarins; Cricetinae; Cysteine Endopeptidases; Daunorubicin; Enzyme Activation; Enzyme Inhibitors; Fluorescent Dyes; HL-60 Cells; Humans; Oligopeptides; Phagocytes; Phagocytosis; Sphingosine; Substrate Specificity; Tumor Cells, Cultured | 1998 |
Apoptosis induction in synovial fibroblasts by ceramide: in vitro and in vivo effects.
Topics: Animals; Apoptosis; Arthritis, Rheumatoid; Fibroblasts; Humans; Injections, Intra-Articular; Male; Mice; Mice, Inbred MRL lpr; Reference Values; Sphingosine; Synovial Membrane | 1998 |
Ceramide activates NFkappaB by inducing the processing of p105.
Topics: DNA; DNA-Binding Proteins; Gene Expression Regulation; HL-60 Cells; Humans; I-kappa B Proteins; Jurkat Cells; NF-kappa B; NF-kappa B p50 Subunit; NF-KappaB Inhibitor alpha; Phosphorylation; Protein Precursors; Sphingosine; Transcriptional Activation; Transfection | 1998 |
Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis.
Topics: Animals; Apoptosis; Cell Membrane Permeability; COS Cells; Enzyme Inhibitors; Motor Neurons; Okadaic Acid; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sphingosine; Tumor Cells, Cultured | 1998 |
In vitro thymocyte maturation is associated with reduced cellular susceptibility to Fas-mediated apoptosis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; bcl-X Protein; Carrier Proteins; Cell Differentiation; Cell Separation; Cells, Cultured; Cold Temperature; fas Receptor; Fas-Associated Death Domain Protein; Female; Hot Temperature; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sphingosine; T-Lymphocytes; Thymus Gland | 1998 |
Neurotrophic factors prevent ceramide-induced apoptosis downstream of c-Jun N-terminal kinase activation in PC12 cells.
Topics: Amino Acid Chloromethyl Ketones; Androstadienes; Animals; Apoptosis; Cell Survival; Chromones; Cyclic AMP; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblast Growth Factor 2; Flavonoids; Hypoglycemic Agents; Insulin; Morpholines; Nerve Growth Factors; Neurons; Neuropeptides; Neuroprotective Agents; PC12 Cells; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-jun; Rats; Sphingosine; Thionucleotides; Wortmannin | 1998 |
A comparison of the effects of lipopolysaccharide and ceramide on arachidonic acid metabolism in THP-1 monocytic cells.
Topics: Arachidonic Acid; Cell Line; Dinoprostone; Humans; Leukotriene C4; Lipopolysaccharides; Monocytes; Sphingomyelin Phosphodiesterase; Sphingosine | 1998 |
The role of the endothelium in ceramide-induced vasodilation.
Topics: Animals; Aorta; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Methylene Blue; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Sprague-Dawley; Sphingosine; Vasodilation | 1998 |
p75 and TrkA receptor signaling independently regulate amyloid precursor protein mRNA expression, isoform composition, and protein secretion in PC12 cells.
Topics: Amyloid beta-Protein Precursor; Animals; Antibodies, Monoclonal; Antioxidants; Blood Proteins; Blotting, Northern; Brain-Derived Neurotrophic Factor; Cell Death; Cholinergic Agents; Cross-Linking Reagents; Enzyme Inhibitors; Gene Expression Regulation; Immunotoxins; Isomerism; N-Glycosyl Hydrolases; Nerve Growth Factors; PC12 Cells; Proto-Oncogene Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Nerve Growth Factor; Receptor, trkA; Receptors, Nerve Growth Factor; Ribosome Inactivating Proteins, Type 1; RNA, Messenger; Saporins; Signal Transduction; Sphingosine | 1998 |
The mitogen-activated protein kinase pathway inhibits ceramide-induced terminal differentiation of a human monoblastic leukemia cell line, U937.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Activation; Humans; Leukemia, Monocytic, Acute; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phenotype; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Retinoblastoma Protein; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Purification and characterization of ceramide-activated protein phosphatases.
Topics: Animals; Blotting, Western; Brain; Ceramides; Chromatography, Agarose; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Phosphoprotein Phosphatases; Rats; Sepharose; Sphingosine | 1998 |
Positive feedback control of neutral sphingomyelinase activity by ceramide.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane Permeability; Cells, Cultured; Ceramides; Daunorubicin; Enzyme Activation; Fibroblasts; HL-60 Cells; Humans; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Cells, Cultured | 1998 |
Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.
Topics: 3T3 Cells; Adipocytes; Animals; Biological Transport; Cell Differentiation; Ceramides; Enzyme Inhibitors; Glucose; Glucose Transporter Type 4; Insulin; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Sphingosine; Transfection | 1998 |
Regulation of membrane release in apoptosis.
Topics: Apoptosis; Arachidonic Acid; Cell Membrane; Cysteine Proteinase Inhibitors; Etoposide; HL-60 Cells; Humans; Kinetics; Leukemia, B-Cell; Membrane Lipids; Palmitic Acid; Phospholipases A; Phospholipases A2; Preleukemia; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Sphingosine; Transfection; Tumor Cells, Cultured; Vincristine | 1998 |
Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic.
Topics: Animals; Apoptosis; Astrocytes; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Free Radical Scavengers; Metalloporphyrins; Neurons; Rats; Sphingosine; Staurosporine; Superoxide Dismutase | 1998 |
Lipopolysaccharide and ceramide use divergent signaling pathways to induce cell death in murine macrophages.
Topics: Animals; Apoptosis; Cell Death; Cytotoxicity, Immunologic; DNA-Binding Proteins; Drug Synergism; Female; Interferon Regulatory Factor-1; Interferon-gamma; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C3H; Mice, Knockout; Necrosis; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphoproteins; Signal Transduction; Sphingosine; Tumor Necrosis Factor-alpha | 1998 |
Radio-sensitive murine thymoma cell line 3SB: characterization of its apoptosis-resistant variants induced by repeated X-irradiation.
Topics: Animals; Antineoplastic Agents; Apoptosis; Daunorubicin; Drug Resistance; Genetic Variation; Methyl Methanesulfonate; Mice; Mitomycin; Mutagens; Radiation Tolerance; Sphingosine; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1998 |
Apoptotic damage of DNA in human leukaemic HL-60 cells treated with C2-ceramide was detected after G1 blockade of the cell cycle.
Topics: Apoptosis; Cell Cycle; Cell Separation; DNA Damage; Enzyme Inhibitors; Flow Cytometry; G1 Phase; HL-60 Cells; Humans; Sphingosine | 1997 |
Activation of Fas ligand/receptor system kills ovarian cancer cell lines by an apoptotic mechanism.
Topics: Antibodies, Monoclonal; Apoptosis; Enzyme Inhibitors; fas Receptor; Female; Humans; Hydrolysis; Ovarian Neoplasms; Receptors, Tumor Necrosis Factor; Sphingomyelins; Sphingosine; Tumor Cells, Cultured | 1998 |
Induction of programmed cell death in human retinoblastoma Y79 cells by C2-ceramide.
Topics: Apoptosis; Bacterial Proteins; Blotting, Western; Cell Survival; Ceramides; DNA Fragmentation; Humans; Interleukin-1; Nucleosomes; Okadaic Acid; Proteins; Proto-Oncogene Proteins c-bcl-2; Retinoblastoma; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1998 |
Glucosylceramide synthase inhibitor inhibits the action of nerve growth factor in PC12 cells.
Topics: Animals; Cell Differentiation; Drosophila Proteins; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Gangliosides; Glucosyltransferases; Glycosphingolipids; Insect Proteins; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Morpholines; Nerve Growth Factors; Neurons; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Rats; Signal Transduction; Sphingosine | 1998 |
Src kinase and PI 3-kinase as a transduction pathway in ceramide-induced contraction of colonic smooth muscle.
Topics: Amino Acid Sequence; Androstadienes; Animals; Benzoquinones; Calcium; Chromones; Colon; Egtazic Acid; Enzyme Inhibitors; In Vitro Techniques; Kinetics; Lactams, Macrocyclic; Models, Biological; Molecular Sequence Data; Morpholines; Muscle Contraction; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Quinones; Rabbits; Rifabutin; Signal Transduction; Sphingosine; src Homology Domains; Substrate Specificity; Wortmannin | 1998 |
The effects of ceramide and its analogues on the secretion of the mucocyst content of Tetrahymena.
Topics: Animals; Antibodies, Monoclonal; Ceramides; Dibucaine; Female; Fluorescence; Lectins; Lysophospholipids; Mice; Mice, Inbred BALB C; Porifera; Psychosine; Sphingomyelins; Sphingosine; Tetrahymena pyriformis | 1998 |
Apoptosis and activation of the sphingomyelin-ceramide pathway induced by oxidized low density lipoproteins are not causally related in ECV-304 endothelial cells.
Topics: Apoptosis; Arteriosclerosis; Calcium; Cell Division; Cell Line; Ceramides; Endothelium, Vascular; Humans; Hydrolysis; Lipoproteins, LDL; Serine Proteinase Inhibitors; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Umbilical Veins | 1998 |
Inhibition of skin carcinomas but not papillomas by sphingosine, N-methylsphingosine, and N-acetylsphingosine.
Topics: Amines; Animals; Antineoplastic Agents; Carcinoma; Dermatologic Agents; Disease-Free Survival; Female; Mice; Mice, Inbred SENCAR; Papilloma; Skin Neoplasms; Sphingosine | 1998 |
Products of sphingolipid catabolism block activation of the p21-activated protein kinases in neutrophils.
Topics: Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Humans; Neutrophil Activation; Neutrophils; p21-Activated Kinases; Protein Serine-Threonine Kinases; Signal Transduction; Sphingosine | 1998 |
Ceramide, a mediator of interleukin 1, tumour necrosis factor alpha, as well as Fas receptor signalling, induces apoptosis of rheumatoid arthritis synovial cells.
Topics: Apoptosis; Arthritis, Rheumatoid; Cell Culture Techniques; Cell Death; Cytokines; DNA; fas Receptor; Humans; Interleukin-1; Signal Transduction; Sphingosine; Synovial Membrane; Tumor Necrosis Factor-alpha | 1998 |
Effects of endoglycoceramidase or D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol on glucose uptake, glycolysis, and mitochondrial respiration in HL60 cells.
Topics: Cell Membrane Permeability; Cell Respiration; Glucose; Glycolysis; Glycoside Hydrolases; HL-60 Cells; Humans; Intracellular Fluid; Mitochondria; Morpholines; Oxidation-Reduction; Sphingosine | 1998 |
Distribution of protein phosphatases type 1 and 2A in RINm5F cells.
Topics: Animals; Biomarkers; Cell Fractionation; Chromosomal Proteins, Non-Histone; DNA-Binding Proteins; Enzyme Inhibitors; Heparin; Histone Chaperones; Islets of Langerhans; Okadaic Acid; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylase a; Protamines; Proteins; Rats; Sphingosine; Transcription Factors; Tumor Cells, Cultured | 1998 |
Tumor necrosis factor-alpha-induced release of plasminogen activator inhibitor-1 from human umbilical vein endothelial cells: involvement of intracellular ceramide signaling event.
Topics: Ceramides; DNA Fragmentation; Endosomes; Endothelium, Vascular; Humans; Lysosomes; Plasminogen Activator Inhibitor 1; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Necrosis Factor-alpha; Umbilical Veins | 1998 |
Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; E-Selectin; Endothelium, Vascular; Enzyme Activation; Gene Expression Regulation; Humans; JNK Mitogen-Activated Protein Kinases; Kinetics; Lysophospholipids; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphotransferases (Alcohol Group Acceptor); Signal Transduction; Sphingomyelins; Sphingosine; Tumor Necrosis Factor-alpha; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 1998 |
Rho A regulates sustained smooth muscle contraction through cytoskeletal reorganization of HSP27.
Topics: ADP Ribose Transferases; Animals; Biological Transport; Botulinum Toxins; Colon; Cytoskeleton; Endothelin-1; GTP-Binding Proteins; Heat-Shock Proteins; Muscle Contraction; Muscle, Smooth; Phosphoinositide-3 Kinase Inhibitors; Rabbits; rhoA GTP-Binding Protein; Sphingosine; Tissue Distribution | 1998 |
C2-ceramide attenuates prostaglandin F2alpha-induced vasoconstriction and elevation of [Ca2+]i in canine cerebral vascular smooth muscle.
Topics: Animals; Calcium; Cells, Cultured; Dinoprost; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Fura-2; In Vitro Techniques; Intracellular Fluid; Male; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Signal Transduction; Sphingosine; Time Factors; Vasoconstriction | 1998 |
Ceramide and cyclic adenosine monophosphate (cAMP) induce cAMP response element binding protein phosphorylation via distinct signaling pathways while having opposite effects on myeloid cell survival.
Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Survival; Ceramides; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Hematopoietic Stem Cells; Humans; Imidazoles; Interleukin-3; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Sphingosine; Tumor Necrosis Factor-alpha; U937 Cells | 1999 |
Increased cyclin E level in retinoblastoma cells during programmed cell death.
Topics: Amsacrine; Apoptosis; Camptothecin; Cyclin A; Cyclin E; Enzyme Inhibitors; Etoposide; Humans; Interleukin-1; Retinoblastoma; Sphingosine; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1998 |
Role of ceramide in lipopolysaccharide (LPS)-induced signaling. LPS increases ceramide rather than acting as a structural homolog.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Ceramides; Dose-Response Relationship, Drug; Enzyme Activation; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Kinetics; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; Molecular Mimicry; NF-kappa B; Signal Transduction; Sphingosine; Tumor Necrosis Factor-alpha | 1999 |
Aryl hydrocarbon receptor regulation of ceramide-induced apoptosis in murine hepatoma 1c1c7 cells. A function independent of aryl hydrocarbon receptor nuclear translocator.
Topics: Animals; Apoptosis; Aryl Hydrocarbon Receptor Nuclear Translocator; DNA-Binding Proteins; Doxorubicin; Liver Neoplasms, Experimental; Mice; Receptors, Aryl Hydrocarbon; Sphingosine; Staurosporine; Transcription Factors; Tumor Cells, Cultured | 1999 |
N-Acetylsphingosine stimulates phosphatidylglycerolphosphate synthase activity in H9c2 cardiac cells.
Topics: Animals; Cardiolipins; Cell Line; Cell Membrane Permeability; Ceramides; Cyclic AMP-Dependent Protein Kinases; DNA; Enzyme Activation; Enzyme Inhibitors; Ligases; Marine Toxins; Mitochondria, Heart; Myocardium; Nucleotides; Okadaic Acid; Oxazoles; Phosphatidylglycerols; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Rats; Sphingosine; Tumor Necrosis Factor-alpha | 1999 |
Acyl chain length-specific ceramide-induced changes in intracellular Ca2+ concentration and progesterone production are not regulated by tumor necrosis factor alpha in hen granulosa cells.
Topics: Animals; Calcium; Carbachol; Ceramides; Chickens; Female; Granulosa Cells; Luteinizing Hormone; Progesterone; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Tumor Necrosis Factor-alpha | 1999 |
Partial lithium-associated protection against apoptosis induced by C2-ceramide in cerebellar granule neurons.
Topics: Animals; Apoptosis; Cells, Cultured; Cerebellum; Drug Administration Schedule; Female; Inositol Phosphates; Lithium; Male; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Sphingosine | 1998 |
Activation of integrin and ceramide signalling pathways can inhibit the mitogenic effect of insulin-like growth factor I (IGF-I) in human breast cancer cell lines.
Topics: Breast Neoplasms; Cell Cycle; Cell Division; Cyclin A; Cyclin B; Cyclin B1; Female; Humans; Insulin-Like Growth Factor I; Kinetics; Oligopeptides; Recombinant Proteins; S Phase; Signal Transduction; Sphingosine; Tumor Cells, Cultured | 1999 |
Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons.
Topics: Animals; Cell Survival; Cells, Cultured; Ceramides; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Glutamic Acid; Lysophospholipids; Mesencephalon; Neurons; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingosine; Time Factors; Tumor Necrosis Factor-alpha | 1999 |
Limited role of ceramide in lipopolysaccharide-mediated mitogen-activated protein kinase activation, transcription factor induction, and cytokine release.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Ceramides; Cytokines; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Signal Transduction; Sphingomyelins; Sphingosine; Transcription Factor AP-1; Transcription Factors | 1999 |
Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2, 5-dibromophenyl)propenamide].
Topics: Agammaglobulinaemia Tyrosine Kinase; Amides; Antineoplastic Agents; Computer Simulation; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; ErbB Receptors; Humans; Janus Kinase 1; Janus Kinase 2; Models, Molecular; Nitriles; Protein Conformation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, Insulin; Sphingosine; src-Family Kinases; Structure-Activity Relationship; Tumor Cells, Cultured; Vincristine | 1999 |
Extended ceramide exposure activates the trkA receptor by increasing receptor homodimer formation.
Topics: 3T3 Cells; Animals; Cell Membrane; Dimerization; Enzyme Inhibitors; G(M1) Ganglioside; Mice; Nerve Growth Factors; Neurons; PC12 Cells; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Nerve Growth Factor; Receptor, trkA; Receptors, Nerve Growth Factor; Sphingosine | 1999 |
The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme.
Topics: Animals; Astrocytes; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carnitine O-Palmitoyltransferase; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Dose-Response Relationship, Drug; Dronabinol; Enzyme Inhibitors; Ketone Bodies; Malonyl Coenzyme A; Mitochondria; Piperidines; Protein Kinase C; Psychotropic Drugs; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine | 1999 |
Effect of C2 ceramide on the inositol phospholipid metabolism (uptake of 32P, 3H-serine and 3H-palmitic acid) and apoptosis-related morphological changes in Tetrahymena.
Topics: Animals; Apoptosis; Chromatin; DNA Fragmentation; Kinetics; Palmitic Acid; Phosphatidylinositols; Phosphorus Radioisotopes; Serine; Sphingosine; Tetrahymena; Tritium | 1999 |
CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide.
Topics: Apoptosis; Blotting, Western; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Ceramides; Cyclins; Dose-Response Relationship, Drug; Etoposide; Humans; Membrane Glycoproteins; Models, Biological; Molecular Chaperones; Neurodegenerative Diseases; Poly(ADP-ribose) Polymerases; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae Proteins; Sphingosine; Staurosporine; Time Factors; Transfection; Vincristine | 1999 |
Differential activation of phosphoinositide 3-kinase by endothelin and ceramide in colonic smooth muscle cells.
Topics: Animals; Calcium; Calcium Chloride; Cells, Cultured; Colon; Egtazic Acid; Endothelin-1; Enzyme Activation; Genistein; Kinetics; Models, Biological; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Rabbits; Signal Transduction; Sphingosine; Time Factors | 1999 |
Fumonisin B1 induces apoptosis in cultured human keratinocytes through sphinganine accumulation and ceramide depletion.
Topics: Apoptosis; beta-Alanine; Carboxylic Acids; Cell Survival; Cells, Cultured; Ceramides; Chromatography, High Pressure Liquid; Colony-Forming Units Assay; DNA Fragmentation; Drug Interactions; Enzyme Inhibitors; Fumonisins; Humans; Keratinocytes; Sphingolipids; Sphingosine; Teratogens | 1999 |
The growth arrest and downregulation of c-myc transcription induced by ceramide are related events dependent on p21 induction, Rb underphosphorylation and E2F sequestering.
Topics: Apoptosis; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Cell Line; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; E2F Transcription Factors; Gene Expression Regulation; Genes, myc; Genes, Reporter; Humans; Phosphorylation; Promoter Regions, Genetic; Retinoblastoma Protein; Retinoblastoma-Binding Protein 1; Sphingosine; Transcription Factor DP1; Transcription Factors; Transcription, Genetic; Transfection | 1998 |
Hydrogen peroxide suppresses U937 cell death by two different mechanisms depending on its concentration.
Topics: Adaptation, Biological; Antioxidants; Apoptosis; bcl-X Protein; Cell Death; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Induction; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Necrosis; Proto-Oncogene Proteins c-bcl-2; Sphingosine; Time Factors; U937 Cells | 1999 |
FK506 prevents stroke-induced generation of ceramide and apoptosis signaling.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain Chemistry; Cerebrovascular Disorders; Enzyme Inhibitors; Fas Ligand Protein; Gene Expression; Humans; Immunosuppressive Agents; Ischemic Attack, Transient; Male; Membrane Glycoproteins; Necrosis; Neuroblastoma; Neurons; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Sphingosine; Tacrolimus; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Up-Regulation | 1999 |
Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction.
Topics: 3T3 Cells; Animals; Binding Sites; Blood Proteins; Cattle; Cell Communication; Cell Line; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Extracellular Matrix; Fetal Blood; Fluorescent Antibody Technique; Green Fluorescent Proteins; Insulin; Luminescent Proteins; Mice; Morpholines; Phosphatidylinositols; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Fusion Proteins; Sphingosine | 1999 |
Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism.
Topics: Amidohydrolases; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Cell Death; Ceramidases; Enzyme Inhibitors; Gamma Rays; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Myristates; Propanolamines; Protein Biosynthesis; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Sphingosine; Vidarabine | 1999 |
Increase of MnSOD expression and decrease of JNK activity determine the TNF sensitivity in bcl2-transfected L929 cells.
Topics: Animals; Apoptosis; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Nucleus; Dactinomycin; DNA Fragmentation; DNA Primers; Genes, bcl-2; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; RNA, Messenger; Sphingosine; Superoxide Dismutase; Transfection; Tumor Necrosis Factor-alpha | 1999 |
Killing of T lymphocytes by synthetic ceramide is by a nonapoptotic mechanism and is abrogated following mitogenic activation.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspases; Cell Death; Cells, Cultured; Cysteine Proteinase Inhibitors; Enzyme Activation; Humans; Jurkat Cells; Lymphocyte Activation; Mitogens; Neoplastic Stem Cells; Okadaic Acid; Phytohemagglutinins; Sphingosine; T-Lymphocytes | 1999 |
Ceramide induces apoptosis to immature cerebellar granule cells in culture.
Topics: Animals; Apoptosis; Cells, Cultured; Ceramides; Cerebellum; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Interleukin-1; Neurons; Nucleic Acid Synthesis Inhibitors; Protein Biosynthesis; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Time Factors; Tumor Necrosis Factor-alpha | 1999 |
Helicobacter pylori-dependent ceramide production may mediate increased interleukin 8 expression in human gastric cancer cell lines.
Topics: Ceramides; Enzyme Inhibitors; Helicobacter Infections; Helicobacter pylori; Humans; Interleukin-8; NF-kappa B; RNA, Messenger; Sphingomyelin Phosphodiesterase; Sphingosine; Stomach Neoplasms; Transcription Factor AP-1; Transcription, Genetic; Tumor Cells, Cultured | 1999 |
Ceramide triggers p53-dependent apoptosis in genetically defined fibrosarcoma tumour cells.
Topics: Animals; Apoptosis; Cell Cycle; Enzyme Inhibitors; Fibrosarcoma; Growth Inhibitors; Mice; Mice, Knockout; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1999 |
Induction and suppression of endothelial cell apoptosis by sphingolipids: a possible in vitro model for cell-cell interactions between platelets and endothelial cells.
Topics: Acetic Anhydrides; Acylation; Apoptosis; Blood Platelets; Cell Communication; DNA; Endothelium, Vascular; Humans; Lysophospholipids; Microscopy, Fluorescence; Sphingolipids; Sphingosine; Umbilical Veins | 1999 |
Effect of ceramide on KCa channel activity and vascular tone in coronary arteries.
Topics: Animals; Calcium; Cattle; Coronary Vessels; Dithiothreitol; Enzyme Inhibitors; Glutathione; In Vitro Techniques; Kinetics; Membrane Potentials; Muscle Tonus; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Potassium Channels; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Vasoconstriction | 1999 |
Increased, not decreased activation of the insulin-like growth factor (IGF) receptor signalling pathway during ceramide-induced apoptosis.
Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Division; Cell Survival; Ceramides; Dose-Response Relationship, Drug; Fibroblasts; Flow Cytometry; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Receptor, IGF Type 1; Signal Transduction; Sphingosine; Time Factors | 1999 |
Ceramide induces caspase-independent apoptosis in rat hepatocytes sensitized by inhibition of RNA synthesis.
Topics: Animals; Apoptosis; Caspases; Cell Line; Cysteine Proteinase Inhibitors; Dactinomycin; Enzyme Inhibitors; Indoles; Liver; Male; NF-kappa B; Nucleic Acid Synthesis Inhibitors; Oligopeptides; Ploidies; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Sphingosine | 1999 |
Inhibition of human erythroid colony formation by ceramide.
Topics: Apoptosis; Ceramides; Colony-Forming Units Assay; Depression, Chemical; Erythroid Precursor Cells; Erythropoiesis; Erythropoietin; fas Receptor; Humans; Interferon-beta; Interferon-gamma; Lysophospholipids; Recombinant Proteins; Sphingomyelin Phosphodiesterase; Sphingosine | 1999 |
Effect of ceramide on interleukin-6 synthesis in osteoblast-like cells.
Topics: Alprostadil; Animals; Bucladesine; Calcimycin; Cell Line; Cholera Toxin; Colforsin; Dinoprost; Interleukin-1; Interleukin-6; Mice; Osteoblasts; Sphingosine; Tetradecanoylphorbol Acetate; Thapsigargin; Thrombin; Tumor Necrosis Factor-alpha | 1999 |
Involvement of the 92-kDa gelatinase (matrix metalloproteinase-9) in the ceramide-mediated inhibition of human keratinocyte growth.
Topics: Antibodies; Apoptosis; Cell Division; Cells, Cultured; Ceramides; Collagenases; Dose-Response Relationship, Drug; Epidermal Growth Factor; Gelatinases; HL-60 Cells; Humans; Keratinocytes; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Phenylalanine; Sphingomyelin Phosphodiesterase; Sphingosine; Thiophenes; Time Factors | 1999 |
Tumor necrosis factor-alpha and ceramides in insulin resistance.
Topics: 3T3 Cells; Adipocytes; Animals; Biological Transport; Ceramides; Deoxyglucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Kinetics; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Sphingosine; Tumor Necrosis Factor-alpha | 1999 |
Induction of the manganese superoxide dismutase gene by sphingomyelinase and ceramide.
Topics: Animals; Antisense Elements (Genetics); Apoptosis; Astrocytes; Blotting, Northern; Cells, Cultured; Ceramides; Cerebral Cortex; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation, Enzymologic; Glomerular Mesangium; Humans; Interleukin-1; Lipopolysaccharides; Lysosomal Storage Diseases; Rats; RNA, Messenger; Skin; Sphingomyelin Phosphodiesterase; Sphingosine; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 1999 |
Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic PC12 cell death.
Topics: Acetylcysteine; Animals; Antioxidants; Caspase 3; Caspases; Cell Death; Cell Differentiation; Cell Hypoxia; Ceramides; Enzyme Activation; Free Radical Scavengers; Glutathione; L-Lactate Dehydrogenase; Neurons; PC12 Cells; Rats; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine | 1999 |
Differential modulation of apoptosis sensitivity in CD95 type I and type II cells.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; B-Lymphocytes; Carrier Proteins; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cells, Cultured; Cycloheximide; Enzyme Activation; fas Receptor; Fas-Associated Death Domain Protein; Hematopoietic Stem Cells; Intracellular Signaling Peptides and Proteins; Models, Biological; Protein Kinase C; Signal Transduction; Sphingosine; T-Lymphocytes | 1999 |
An essential role for mitogen-activated protein kinases, ERKs, in preventing heat-induced cell death.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Death; Enzyme Activation; HL-60 Cells; Hot Temperature; Humans; K562 Cells; Leukemia; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-raf; Sphingosine; Transfection; U937 Cells | 1999 |
The role of cell surface attachment and proteolysis in the insulin-like growth factor (IGF)-independent effects of IGF-binding protein-3 on apoptosis in breast epithelial cells.
Topics: Animals; Apoptosis; Breast Neoplasms; Carcinoma; Cell Membrane; DNA Fragmentation; Drug Synergism; Epithelial Cells; Female; Humans; Insulin-Like Growth Factor Binding Protein 3; Peptide Hydrolases; Recombinant Proteins; Serine Proteinase Inhibitors; Somatomedins; Sphingosine; Sulfones; Tumor Cells, Cultured | 1999 |
Ceramide-induced apoptosis occurs independently of caspases and is decreased by leupeptin.
Topics: Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; fas Receptor; Female; Humans; Leupeptins; Necrosis; Sphingosine; Tumor Cells, Cultured; U937 Cells | 1999 |
Characterization of Apt- cell lines exhibiting cross-resistance to glucocorticoid- and Fas-mediated apoptosis.
Topics: Animals; Apoptosis; Caspases; Dexamethasone; Enzyme Inhibitors; fas Receptor; Glucocorticoids; Humans; Mice; Mutagenesis; Sphingosine; Staurosporine; Tumor Cells, Cultured | 1999 |
Potentiation by vitamin D analogs of TNFalpha and ceramide-induced apoptosis in MCF-7 cells is associated with activation of cytosolic phospholipase A2.
Topics: Antigens, CD; Apoptosis; Calcitriol; Cell Survival; Cytosol; Cytotoxicity, Immunologic; Drug Synergism; Enzyme Activation; Humans; Phospholipases A; Phospholipases A2; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Sphingosine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1999 |
Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.
Topics: Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Division; Cell Line; Cell Survival; Cytosol; DNA; Enzyme Activation; fas Receptor; Humans; Lysophospholipids; Mice; Peptide Hydrolases; Pertussis Toxin; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Recombinant Fusion Proteins; Second Messenger Systems; Sphingosine; Transfection; Virulence Factors, Bordetella | 1999 |
Effect of ceramide on apoptosis and phospholipase D activity in FRTL-5 thyroid cells.
Topics: Animals; Apoptosis; Cells, Cultured; DNA Fragmentation; Enzyme Activation; Flow Cytometry; Gene Expression Regulation, Enzymologic; Phospholipase D; Rats; Rats, Inbred Strains; RNA, Messenger; Sphingosine; Thyroid Gland; Thyrotropin | 1999 |
1-O-acylceramide synthase.
Topics: Acylation; Acyltransferases; Animals; Arachidonic Acid; Brain; Cattle; Cells, Cultured; Ceramides; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipases A2; Sphingolipids; Sphingosine | 2000 |
Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism.
Topics: Annexin A5; Apoptosis; Benzoxazines; DNA Fragmentation; Dronabinol; Fluorescent Antibody Technique; Humans; Indoles; Male; Mitochondria; Morpholines; Naphthalenes; Pertussis Toxin; Piperidines; Prostatic Neoplasms; Protein Binding; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Sphingosine; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1999 |
Redistribution of cytochrome c is not an essential requirement in C2-ceramide induced apoptosis in HL-60 cells.
Topics: Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cytochrome c Group; Enzyme Activation; Enzyme Inhibitors; HL-60 Cells; Humans; Proto-Oncogene Proteins c-bcl-2; Sodium Dodecyl Sulfate; Sphingosine | 1999 |
Role of PI 3-kinase in angiopoietin-1-mediated migration and attachment-dependent survival of endothelial cells.
Topics: Angiopoietin-1; Apoptosis; Cell Adhesion; Cell Movement; Cell Survival; Chromones; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Fibroblast Growth Factor 2; Humans; Lymphokines; Membrane Glycoproteins; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sphingosine; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1999 |
Possible involvement of cytochrome c release and sequential activation of caspases in ceramide-induced apoptosis in SK-N-MC cells.
Topics: Apoptosis; Caspase Inhibitors; Caspases; Cell-Free System; Cytochrome c Group; Cytosol; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Humans; L-Lactate Dehydrogenase; Neuroblastoma; Reverse Transcriptase Polymerase Chain Reaction; Sphingosine; Time Factors; Tumor Cells, Cultured | 1999 |
Induction of apoptosis by novel synthesized acylamides of human lymphocytes.
Topics: Alanine; Amides; Antibodies; Apoptosis; Caspase 3; Caspase Inhibitors; Cell Survival; DNA Fragmentation; Enzyme Inhibitors; Humans; Intracellular Membranes; Jurkat Cells; Lymphocytes; Membrane Potentials; Myristic Acids; Sphingosine; Structure-Activity Relationship | 2000 |
Nerve growth factor stimulates MAPK via the low affinity receptor p75(LNTR).
Topics: Age Factors; Animals; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Neurons; Oncogene Protein p21(ras); Phosphorylation; Rats; Receptor, Nerve Growth Factor; Sphingosine | 1999 |
p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis.
Topics: 14-3-3 Proteins; Animals; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Carrier Proteins; cdc42 GTP-Binding Protein; Cell Line; Cell Survival; Enzyme Activation; Interleukin-3; Mice; Mutation; p21-Activated Kinases; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphoserine; Protein Binding; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins c-bcl-2; rho GTP-Binding Proteins; Signal Transduction; Sphingosine; Tyrosine 3-Monooxygenase | 2000 |
Indications for an active process underlying spontaneous and radiation-induced micronucleation in L929 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aurintricarboxylic Acid; Benzhydryl Compounds; Bromodeoxyuridine; Cell Division; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; DNA, Neoplasm; Electrophoresis, Gel, Pulsed-Field; Endonucleases; Enzyme Inhibitors; Fibrosarcoma; Mice; Micronuclei, Chromosome-Defective; Micronucleus Tests; Proliferating Cell Nuclear Antigen; Protein Kinase C; Spermine; Sphingosine; Teniposide; Topoisomerase II Inhibitors; Transcription, Genetic; Tumor Cells, Cultured | 1999 |
Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage.
Topics: Animals; Annexin A5; Apoptosis; Cartilage, Articular; Cells, Cultured; Ceramides; Collagenases; Interleukin-1; Kinetics; Male; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Phenylalanine; Protease Inhibitors; Proteoglycans; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; Sphingomyelin Phosphodiesterase; Sphingosine; Thiophenes; Transcription, Genetic | 2000 |
Requirement of calmodulin binding by HIV-1 gp160 for enhanced FAS-mediated apoptosis.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Apoptosis; Binding Sites; Calmodulin; Caspase 3; Caspases; Enzyme Activation; fas Receptor; HIV Envelope Protein gp160; HIV-1; Humans; Jurkat Cells; Models, Molecular; Molecular Sequence Data; Myosin-Light-Chain Kinase; Peptide Fragments; Point Mutation; Protein Structure, Secondary; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Sphingosine; Transfection; Tryptophan | 2000 |
Lipid metabolic changes caused by short-chain ceramides and the connection with apoptosis.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Apoptosis; Boron Compounds; Cell Line; Ceramides; Cholesterol; Cricetinae; Fibroblasts; Kidney; Lipid Metabolism; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylserines; Sphingolipids; Sphingomyelins; Sphingosine | 2000 |
Hypoxic preconditioning protects cultured neurons against hypoxic stress via TNF-alpha and ceramide.
Topics: Animals; Antigens, CD; Biomarkers; Brain Ischemia; Cell Count; Cell Hypoxia; Cell Survival; Cells, Cultured; Ceramides; Cerebral Cortex; Ischemic Preconditioning; Neurons; Oxygen; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Sphingosine; Tumor Necrosis Factor-alpha; Up-Regulation | 2000 |
Caspases mediate C2-ceramide-induced apoptosis of the human oligodendroglial cell line, MO3.13.
Topics: Apoptosis; Carrier Proteins; Caspase 3; Caspases; Cell Line, Transformed; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Humans; Immunoblotting; Microfilament Proteins; Oligodendroglia; Sphingosine | 2000 |
Effect of ceramide on intracellular glutathione determines apoptotic or necrotic cell death of JB6 tumor cells.
Topics: Acetylcysteine; Animals; Apoptosis; Drug Resistance; Glutathione; Mice; Necrosis; Propidium; Reactive Oxygen Species; Skin Neoplasms; Sphingosine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2000 |
Ganglioside GD3, the mitochondrial permeability transition, and apoptosis.
Topics: Animals; Apoptosis; Calcium; Cytochrome c Group; Gangliosides; Intracellular Membranes; Kinetics; Male; Mitochondria, Liver; Permeability; Rats; Rats, Inbred F344; Sphingosine | 1999 |
Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells.
Topics: Androstadienes; Animals; Cell Nucleus; Enzyme Activation; Kinetics; Mice; Nerve Growth Factor; PC12 Cells; Phosphoprotein Phosphatases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Recombinant Fusion Proteins; Sphingosine; Transfection; Wortmannin | 2000 |
In vivo evidence that activation of tyrosine kinase is a trigger for lipopolysaccharide-induced fever in rats.
Topics: Animals; Antibodies; Body Temperature; Brain; Enzyme Inhibitors; Fever; Genistein; Injections, Intraventricular; Interleukin-1; Lipopolysaccharides; Male; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Rectum; Sphingosine; Tumor Necrosis Factor-alpha | 2000 |
C2-Ceramide increases cytoplasmic calcium concentrations in human parathyroid cells.
Topics: Calcium; Cytoplasm; Enzyme Inhibitors; Homeostasis; Humans; Microscopy, Confocal; Parathyroid Glands; Sphingosine; Tumor Cells, Cultured | 2000 |
Regulation of rheumatoid synovial cell growth by ceramide.
Topics: Apoptosis; Arthritis, Rheumatoid; Cell Division; Cells, Cultured; Enzyme Activation; Humans; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Platelet-Derived Growth Factor; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Sphingosine; Synovial Membrane | 2000 |
Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzoxazines; Brain Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cannabinoids; Ceramides; DNA-Binding Proteins; Dronabinol; Glioma; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Sphingomyelins; Sphingosine; Tumor Cells, Cultured | 2000 |
Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis?
Topics: Animals; Apoptosis; Cell Count; Cell Death; Cells, Cultured; Cerebral Cortex; Coloring Agents; Cycloheximide; Enzyme Inhibitors; Fetus; L-Lactate Dehydrogenase; Mice; Nerve Growth Factors; Neuroglia; Neurons; Neuroprotective Agents; Reproducibility of Results; Sphingosine; Tetrazolium Salts; Thiazoles; Trypan Blue | 2000 |
Suppression of heat shock protein-70 by ceramide in heat shock-induced HL-60 cell apoptosis.
Topics: Apoptosis; Ceramides; DNA-Binding Proteins; Gene Expression Regulation; Heat Shock Transcription Factors; Heat-Shock Response; HL-60 Cells; HSP70 Heat-Shock Proteins; Humans; Protein Biosynthesis; RNA Processing, Post-Transcriptional; Sphingosine; Transcription Factors; Transcription, Genetic | 2000 |
Induction of apoptosis by all-trans-retinoic acid and C2-ceramide treatment in rat stromal-vascular cultures.
Topics: Adipocytes; Adipose Tissue; Animals; Apoptosis; Inguinal Canal; Insulin; Rats; Rats, Sprague-Dawley; Sphingosine; Stem Cells; Stromal Cells; Tretinoin; Triiodothyronine | 2000 |
Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells.
Topics: Apoptosis; Caspase 3; Caspases; Cell Division; Cell Membrane; Cell Survival; Chromones; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Morpholines; Neuroblastoma; Neurons; Palmitoyl Coenzyme A; Palmitoyl-CoA Hydrolase; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Sphingosine; Transfection; Tumor Cells, Cultured | 2000 |
Ceramide path in human lung cell death.
Topics: Apoptosis; Ceramides; Diglycerides; DNA Fragmentation; Enzyme Activation; Epithelial Cells; Humans; Hydrogen Peroxide; Hydrolysis; Inflammation; Lung; Membrane Lipids; Oxidative Stress; Protein Kinase C; Second Messenger Systems; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Tetradecanoylphorbol Acetate | 2000 |
Ceramide-induced cell death is independent of the Fas/Fas ligand pathway and is prevented by Nur77 overexpression in A20 B cells.
Topics: Animals; Apoptosis; B-Lymphocytes; Caspase 1; Caspase 3; Caspases; Cell Cycle Proteins; Ceramides; Cyclin A; Cyclin E; Cyclin-Dependent Kinase Inhibitor p27; Cysteine Endopeptidases; DNA-Binding Proteins; Enzyme Activation; Fas Ligand Protein; fas Receptor; Gene Expression; Membrane Glycoproteins; Mice; Microtubule-Associated Proteins; Nuclear Receptor Subfamily 4, Group A, Member 1; Proto-Oncogene Proteins c-myc; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Retinoblastoma Protein; Sphingosine; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2000 |
Ceramides that mediate apoptosis reduce glucose uptake and transporter affinity for glucose in human leukaemic cell lines but not in neutrophils.
Topics: Apoptosis; Cell Division; Cell Survival; Ceramides; Deoxyglucose; Dose-Response Relationship, Drug; Formazans; Glucose; Humans; Jurkat Cells; Monosaccharide Transport Proteins; Neutrophils; Sphingomyelin Phosphodiesterase; Sphingosine; Tetrazolium Salts; Tumor Cells, Cultured; U937 Cells | 2000 |
Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of l -cysteine.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Cysteine; Cytokines; Dose-Response Relationship, Immunologic; HIV Envelope Protein gp120; HIV-1; Humans; Immune Sera; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Macrophage Activation; Macrophages; Monocytes; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1; Receptors, N-Methyl-D-Aspartate; Sialoglycoproteins; Sphingosine; Tumor Necrosis Factor-alpha | 2000 |
Nitric oxide inhibits the tumor necrosis factor alpha -regulated endocytosis of human dendritic cells in a cyclic GMP-dependent way.
Topics: Animals; Blotting, Western; Brain; Cells, Cultured; Ceramides; Coculture Techniques; Cyclic GMP; Dendritic Cells; Down-Regulation; Endocytosis; Enzyme Inhibitors; Flow Cytometry; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-4; Leukocytes, Mononuclear; Lipopolysaccharides; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Sphingosine; Time Factors; Tumor Necrosis Factor-alpha | 2000 |
Ceramide-induced cell death in cultured rat retinal pigment epithelial cells.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase Inhibitors; Cell Survival; Cells, Cultured; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Pigment Epithelium of Eye; Rats; Rats, Long-Evans; Sphingosine | 2000 |
Protective roles for ATM in cellular response to oxidative stress.
Topics: Animals; Antioxidants; Apoptosis; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Bleomycin; Catalase; Cell Cycle Proteins; Cell Line; Chickens; Chromosome Aberrations; Dexamethasone; DNA-Binding Proteins; Glutathione Peroxidase; Hydrogen Peroxide; Mutation; Oxidants; Oxidative Stress; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Sphingosine; Tumor Suppressor Proteins; X-Rays | 2000 |
Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide.
Topics: Antigens, CD; Apoptosis; Caspase 8; Caspase 9; Caspases; Ceramides; Cyclic GMP; Enzyme Inhibitors; Humans; Kinetics; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Proteins; Quinoxalines; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; S-Nitroso-N-Acetylpenicillamine; Second Messenger Systems; Signal Transduction; Sphingosine; TNF Receptor-Associated Factor 1; Tumor Necrosis Factor-alpha; U937 Cells | 2000 |
Tumor necrosis factor-alpha-induced apoptosis is associated with suppression of insulin-like growth factor binding protein-5 secretion in differentiating murine skeletal myoblasts.
Topics: Animals; Apoptosis; Cell Cycle; Cell Line; Creatine Kinase; Fibroblast Growth Factor 2; Humans; Insulin-Like Growth Factor Binding Protein 5; Insulin-Like Growth Factor II; Mice; Muscle, Skeletal; Recombinant Proteins; Second Messenger Systems; Sphingosine; Transfection; Tumor Necrosis Factor-alpha | 2000 |
Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release.
Topics: Adaptor Proteins, Signal Transducing; Antibodies, Monoclonal; Apoptosis; Carrier Proteins; Caspase 3; Caspase 8; Caspase 9; Caspases; Cytochrome c Group; DNA Fragmentation; Drug Resistance, Neoplasm; Enzyme Activation; Fas Ligand Protein; fas Receptor; Fas-Associated Death Domain Protein; Gene Expression; Humans; Hydrolysis; Melanoma; Membrane Glycoproteins; Mitochondria; RNA, Messenger; Signal Transduction; Sphingomyelins; Sphingosine; Tumor Cells, Cultured | 2000 |
Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells.
Topics: Apoptosis; Cell Survival; Enzyme Inhibitors; Flavonoids; Humans; Neuroblastoma; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Cells, Cultured | 2000 |
Ceramide inhibits L-type calcium channel currents in rat pinealocytes.
Topics: Animals; Calcium Channels, L-Type; Cells, Cultured; Cyclic AMP; Cyclic GMP; Isoproterenol; Male; Membrane Potentials; Patch-Clamp Techniques; Pineal Gland; Potassium Chloride; Rats; Rats, Sprague-Dawley; Sphingosine | 1999 |
Ceramide-mediated stimulation of inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation in murine macrophages requires tyrosine kinase activity.
Topics: Animals; Benzoquinones; Cell Line; Ceramides; Enzyme Induction; Enzyme Inhibitors; Genistein; Interferon-gamma; Lactams, Macrocyclic; Macrophage Activation; Macrophages; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Recombinant Proteins; Rifabutin; Sphingosine; Tumor Necrosis Factor-alpha | 2000 |
Involvement of SAPK/JNK pathway in X-ray-induced rapid cell death of human T-cell leukemia cell line MOLT-4.
Topics: Animals; Blotting, Southern; Blotting, Western; Bridged-Ring Compounds; Cell Death; Cell Line; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Humans; Leukemia, T-Cell; Mice; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Norbornanes; Phosphodiesterase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Thiocarbamates; Thiones; Time Factors; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53; X-Rays | 2000 |
Failure of gelsolin overexpression to regulate lymphocyte apoptosis.
Topics: Apoptosis; Cell Division; Cell Line; Cytokines; Enzyme Inhibitors; fas Receptor; Gelsolin; Humans; Jurkat Cells; Kinetics; Recombinant Proteins; Sphingosine; T-Lymphocytes; Transfection | 2000 |
The role of ceramide in the modulation of intracellular Ca2+ levels by interleukin 1 beta in rat cortical synaptosomes.
Topics: Animals; Calcium; Ceramides; Cerebral Cortex; Interleukin-1; Intracellular Fluid; Male; Mitogen-Activated Protein Kinase 1; Rats; Rats, Wistar; Sphingosine; Synaptosomes | 2000 |
Clustering of distinct autoimmune diseases associated with functional abnormalities of T cell survival in children.
Topics: Adolescent; Apoptosis; Autoimmune Diseases; Cell Survival; Cells, Cultured; Diabetes Mellitus, Type 1; fas Receptor; Female; Humans; Immunophenotyping; Leukocytes, Mononuclear; Male; Sphingosine; T-Lymphocytes | 2000 |
Lack of costimulation by both sphingomyelinase and C2 ceramide in resting human T cells.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; B7-1 Antigen; CD3 Complex; Cell Culture Techniques; Cell Division; Cell Survival; Enzyme Inhibitors; Humans; Jurkat Cells; Lectins, C-Type; Lymphocyte Activation; Receptors, Interleukin-2; Sphingomyelin Phosphodiesterase; Sphingosine; T-Lymphocytes; Up-Regulation | 2000 |
Mechanisms by which short-chain ceramides cause apoptosis.
Topics: Acetates; Animals; Anticholesteremic Agents; Apoptosis; Cell Line; Ceramides; Cricetinae; Dose-Response Relationship, Drug; Fibroblasts; Kidney; Phosphatidylcholines; Sphingomyelins; Sphingosine | 1999 |
Effect of dimethylsphingosine on muscarinic M(3) receptor signalling in SH-SY5Y cells.
Topics: Brain Neoplasms; Calcium; Cell Line; Enzyme Inhibitors; GTP-Binding Proteins; Humans; Image Processing, Computer-Assisted; Inositol 1,4,5-Trisphosphate; Lysophospholipids; Methacholine Chloride; Muscarinic Agonists; N-Methylscopolamine; Neuroblastoma; Receptor, Muscarinic M3; Receptors, Muscarinic; Signal Transduction; Sphingosine | 2000 |
Implication of sphingolipid metabolism in the stability of the Golgi apparatus.
Topics: Animals; Brefeldin A; Cattle; Cell Line; Ceramides; Coat Protein Complex I; Endocannabinoids; Endosomes; Enzyme Inhibitors; Ethanolamines; Golgi Apparatus; Masoprocol; Microscopy, Electron; Morpholines; Nocodazole; Oleic Acids; Sphingolipids; Sphingomyelin Phosphodiesterase; Sphingosine; trans-Golgi Network | 2000 |
Ceramides induce apoptosis in HeLa cells and enhance cytochrome c-induced apoptosis in Xenopus egg extracts.
Topics: Animals; Apoptosis; Caspase Inhibitors; Caspases; Cell Nucleus; Cell-Free System; Cytochrome c Group; DNA Fragmentation; HeLa Cells; Humans; Mice; Microscopy, Electron; Microscopy, Fluorescence; Mitochondria, Liver; Oocytes; Signal Transduction; Sphingosine; Xenopus | 2000 |
Ceramide 2 (N-acetyl sphingosine) is associated with reduction in Bcl-2 protein levels by Western blotting and with apoptosis in cultured human keratinocytes.
Topics: Apoptosis; Blotting, Western; Cell Count; Cell Division; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Down-Regulation; Flow Cytometry; Humans; In Situ Nick-End Labeling; Infant, Newborn; Keratinocytes; Proto-Oncogene Proteins c-bcl-2; Sphingosine | 2000 |
Ceramide-induced TCR up-regulation.
Topics: Amino Acid Motifs; Down-Regulation; Enzyme Activation; Exocytosis; Humans; Jurkat Cells; Kinetics; Leucine; Leukocytes, Mononuclear; Lymphocyte Activation; Membrane Proteins; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Protein Kinase C; Protein Phosphatase 2; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Antigen, T-Cell; Sphingosine; T-Lymphocytes; Up-Regulation | 2000 |
Mitochondrial free calcium levels (Rhod-2 fluorescence) and ultrastructural alterations in neuronally differentiated PC12 cells during ceramide-dependent cell death.
Topics: Animals; Calcimycin; Calcium; Cell Death; Cell Differentiation; Endoplasmic Reticulum; Fluorescence; Fluorescent Dyes; Heterocyclic Compounds, 3-Ring; Mitochondria; Neurons; PC12 Cells; Rats; Sphingosine; Time Factors | 2000 |
The effect of a ceramide analog, N-acetylsphingosine on the induction of proliferation and IL-2 synthesis in T cells from young and old F344 rats.
Topics: Aging; Animals; Apoptosis; Cell Division; Growth Inhibitors; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Male; Rats; Rats, Inbred F344; Sphingosine; T-Lymphocytes | 2000 |
Induction of tissue factor production but not the upregulation of adhesion molecule expression by ceramide in human vascular endothelial cells.
Topics: Antigens, CD; Apoptosis; Cell Line; Endothelium, Vascular; HL-60 Cells; Humans; Intercellular Adhesion Molecule-1; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Necrosis Factor-alpha; U937 Cells; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 2000 |
Bcl-2 transfected HaCaT keratinocytes resist apoptotic signals of ceramides, tumor necrosis factor alpha and 1 alpha, 25-dihydroxyvitamin D(3).
Topics: Apoptosis; Calcitriol; Cell Line; DNA Fragmentation; Dose-Response Relationship, Drug; Gene Expression Regulation; Genes, bcl-2; Genetic Vectors; Humans; Keratinocytes; Phosphatidylserines; Sphingosine; Transfection; Tumor Necrosis Factor-alpha | 2000 |
Sphingolipids and cholesterol modulate membrane susceptibility to cytosolic phospholipase A(2).
Topics: Animals; Calcimycin; Ceramides; CHO Cells; Cholesterol; Cricetinae; Cytosol; Enzyme Activation; Enzyme Inhibitors; Epinephrine; Fatty Acids; Humans; Ionophores; Lipid Bilayers; Liposomes; Membrane Lipids; Phospholipases A; Phospholipids; Rats; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Sphingolipids; Sphingosine | 2000 |
The lipids C2- and C16-ceramide form large stable channels. Implications for apoptosis.
Topics: Apoptosis; Ceramides; Cholesterol; Electric Conductivity; Electrochemistry; Ion Channels; Liposomes; Models, Biological; Models, Molecular; Molecular Conformation; Phosphatidylcholines; Phospholipids; Sphingosine; Structure-Activity Relationship | 2000 |
Ceramide-induced apoptosis of human thyroid cancer cells resistant to apoptosis by irradiation.
Topics: Apoptosis; Blood; Colforsin; Cyclic AMP-Dependent Protein Kinases; Diglycerides; Enzyme Activation; Gamma Rays; Humans; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Phorbol Esters; Protein Kinase C; Second Messenger Systems; Signal Transduction; Sphingosine; Thyroid Neoplasms; Tumor Cells, Cultured | 2000 |
Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide.
Topics: Adipocytes; Adipose Tissue, Brown; Animals; Apoptosis; Cattle; Cell Line, Transformed; Ceramides; Enzyme Inhibitors; Insulin; Mice; Moloney murine leukemia virus; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Ribosomal Protein S6 Kinases; Sphingosine; Transfection | 2000 |
Inhibition of phosphatidylcholine synthesis precedes apoptosis induced by C2-ceramide: protection by exogenous phosphatidylcholine.
Topics: Animals; Animals, Newborn; Apoptosis; Cell Membrane; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Neurons; Neuroprotective Agents; Phosphatidylcholines; Rats; Rats, Wistar; Signal Transduction; Sphingosine | 2000 |
Akt regulates cell survival and apoptosis at a postmitochondrial level.
Topics: Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Caspase 3; Caspase 9; Caspases; Cell Extracts; Cell Line; Cell Survival; Cell-Free System; Cytochrome c Group; Enzyme Activation; Humans; Hybrid Cells; Microinjections; Mitochondria; Motor Neurons; Phosphatidylinositol 3-Kinases; Poly(ADP-ribose) Polymerases; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Sphingosine | 2000 |
Regulation of phospholipase D activity and ceramide production in daunorubicin-induced apoptosis in A-431 cells.
Topics: Apoptosis; Ceramides; Daunorubicin; Diglycerides; Enzyme Activation; Humans; Phospholipase D; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Cells, Cultured | 2000 |
Filopodial behavior is dependent on the phosphorylation state of neuronal growth cones.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Carrier Proteins; Cells, Cultured; Cerebrosides; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Genistein; Growth Cones; Indole Alkaloids; Intracellular Signaling Peptides and Proteins; Models, Biological; Myosin-Light-Chain Kinase; Naphthalenes; Neurons; Okadaic Acid; Phosphorylation; Protein Kinase C; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Pseudopodia; Signal Transduction; Snails; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors; Vanadates | 2000 |
Release of plasminogen activator inhibitor-1 from human astrocytes is regulated by intracellular ceramide.
Topics: Animals; Antibiotics, Antineoplastic; Astrocytes; Cell Death; Ceramides; Culture Media, Conditioned; Daunorubicin; Enzyme Inhibitors; Humans; Neurons; PC12 Cells; Plasminogen Activator Inhibitor 1; Rats; Sphingosine; Tissue Plasminogen Activator; Tumor Necrosis Factor-alpha | 2000 |
C2-ceramide induces apoptosis in a human squamous cell carcinoma cell line.
Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Size; Cell Survival; Ceramides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; In Situ Nick-End Labeling; Microscopy, Electron; Skin Neoplasms; Sphingosine; Tumor Cells, Cultured | 2000 |
The protective effect of ceramide in immature rat brain hypoxia-ischemia involves up-regulation of bcl-2 and reduction of TUNEL-positive cells.
Topics: Animals; Apoptosis; Brain; Disease Models, Animal; Gene Expression Regulation; Genes, bcl-2; Hypoxia-Ischemia, Brain; In Situ Nick-End Labeling; Infusions, Parenteral; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingosine; Stereotaxic Techniques; Tumor Necrosis Factor-alpha | 2001 |
Ceramide does not inhibit protein kinase C beta-dependent phospholipase D activity stimulated by anti-Fas monoclonal antibody in A20 cells.
Topics: Animals; Antibodies, Monoclonal; Bridged-Ring Compounds; Cell Membrane; Ceramides; Cytosol; Diglycerides; Enzyme Activation; fas Receptor; Isoenzymes; Mice; Norbornanes; Phospholipase D; Protein Kinase C; Protein Kinase C beta; Protein Transport; Receptor Aggregation; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Thiocarbamates; Thiones; Tumor Cells, Cultured; Type C Phospholipases | 2000 |
t-SNARE dephosphorylation promotes SNARE assembly and exocytosis in yeast.
Topics: Exocytosis; Fungal Proteins; Membrane Fusion; Membrane Proteins; Models, Biological; Mutagenesis, Site-Directed; Mutation; Phosphoprotein Phosphatases; Phosphorylation; Qa-SNARE Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; SNARE Proteins; Sphingosine; Temperature; Vesicular Transport Proteins | 2001 |
C2-ceramide and reactive oxygen species inhibit pituitary adenylate cyclase activating polypeptide (PACAP)-induced cyclic-AMP-dependent signalling pathway.
Topics: Adenylyl Cyclases; Cell Line; Cyclic AMP; GTP-Binding Proteins; Neuropeptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Tyrosine Phosphatases; Reactive Oxygen Species; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; Receptors, Pituitary Hormone; Signal Transduction; Sphingosine | 2001 |
Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells.
Topics: Androstadienes; Blotting, Western; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Serine; Sphingosine; Threonine; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins; Wortmannin | 2001 |
T-cell receptor downregulation by ceramide-induced caspase activation and cleavage of the zeta chain.
Topics: Amino Acid Chloromethyl Ketones; Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Apoptosis; Binding Sites; Caspases; Cysteine Proteinase Inhibitors; Down-Regulation; Enzyme Activation; Humans; Jurkat Cells; Membrane Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligopeptides; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Receptors, Antigen, T-Cell, gamma-delta; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Sphingosine; Transfection | 2001 |
Cell cycle arrest of hematopoietic cell lines after treatment with ceramide is commonly associated with retinoblastoma activation.
Topics: Cell Cycle; Enzyme Inhibitors; Flow Cytometry; G1 Phase; Hematopoietic Stem Cells; HL-60 Cells; Humans; Jurkat Cells; Leukemia; Phosphorylation; Resting Phase, Cell Cycle; Retinoblastoma Protein; Sphingosine; Tumor Cells, Cultured; U937 Cells | 2001 |
Ceramide dissociates 3'-phosphoinositide production from pleckstrin homology domain translocation.
Topics: 3T3 Cells; Animals; Blood Proteins; Ceramides; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Glucose Transporter Type 4; Isoenzymes; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phospholipase C delta; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sequence Homology, Amino Acid; Sphingolipids; Sphingosine; Structure-Activity Relationship; Type C Phospholipases | 2001 |
Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IkappaB kinase 1/2 in human alveolar epithelial cells.
Topics: Cell Nucleus; Ceramides; Cyclooxygenase 2; Drug Interactions; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Epithelium; Flavonoids; Humans; I-kappa B Kinase; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Membrane Proteins; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Mutation; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Pulmonary Alveoli; Pyridines; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2001 |
NF-kappa B mediates the adaptation of human U937 cells to hydrogen peroxide.
Topics: Adaptation, Physiological; DNA Fragmentation; Humans; Hydrogen Peroxide; I-kappa B Kinase; NF-kappa B; Oxidative Stress; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Sphingosine; U937 Cells | 2001 |
Hepatocyte growth factor protects gastric epithelial cells against ceramide-induced apoptosis through induction of cyclooxygenase-2.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Ceramides; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Induction; Gastric Mucosa; Hepatocyte Growth Factor; Humans; In Situ Nick-End Labeling; Isoenzymes; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Sulfonamides; Transcription, Genetic | 2000 |
Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.
Topics: Amides; Amidohydrolases; Animals; Apoptosis; Ceramidases; Ceramides; Colonic Neoplasms; Enzyme Inhibitors; Growth Inhibitors; Humans; Liver; Liver Neoplasms, Experimental; Male; Mice; Myristates; Propanolamines; Rats; Rats, Wistar; Sphingosine; Xenograft Model Antitumor Assays | 2001 |
Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells.
Topics: Adrenal Gland Neoplasms; Animals; Apoptosis; Caspase 2; Caspase 3; Caspase 7; Caspases; Culture Media, Serum-Free; JNK Mitogen-Activated Protein Kinases; Kinetics; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nerve Growth Factor; PC12 Cells; Pertussis Toxin; Pheochromocytoma; Phosphotransferases (Alcohol Group Acceptor); Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Recombinant Proteins; Sphingosine; Transfection; Virulence Factors, Bordetella | 2001 |
Subtype-specific translocation of the delta subtype of protein kinase C and its activation by tyrosine phosphorylation induced by ceramide in HeLa cells.
Topics: Adenoviridae; Animals; Antineoplastic Agents; Cell Fractionation; Cell Line; Cell Membrane; Ceramides; CHO Cells; Cricetinae; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Golgi Apparatus; Green Fluorescent Proteins; HeLa Cells; Humans; Immunoblotting; Interferon-gamma; Isoenzymes; Luminescent Proteins; Magnesium; Phorbol Esters; Phosphatidylserines; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Transport; Recombinant Fusion Proteins; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Time Factors; Tyrosine | 2001 |
Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors.
Topics: Antigens, Differentiation; Apoptosis; CCAAT-Enhancer-Binding Proteins; Cell Cycle Proteins; Cell Division; Cell Nucleus; Ceramides; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Fragmentation; Enzyme Inhibitors; fas Receptor; Fluorescent Dyes; GADD45 Proteins; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Phenotype; Plasmids; Protein Phosphatase 1; Proteins; Proto-Oncogene Proteins c-bcl-2; Radiation, Ionizing; Serpins; Signal Transduction; Sphingosine; Time Factors; Transcription Factor CHOP; Transcription Factors; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; U937 Cells; Up-Regulation; Viral Proteins | 2001 |
Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.
Topics: Biological Transport; Cell Line; Cell Membrane; Enzyme Activation; Glucose; Glycogen; Inositol Phosphates; Insulin; Insulin Receptor Substrate Proteins; Muscle, Skeletal; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Sphingosine | 2001 |
Short-chain ceramide regulates hepatic methionine adenosyltransferase expression.
Topics: Animals; Cells, Cultured; Gene Expression Regulation, Enzymologic; Hepatocytes; Interleukin-6; Isoenzymes; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Methionine; Methionine Adenosyltransferase; Rats; RNA, Messenger; Sphingosine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2001 |
Loss of cyclin A and G1-cell cycle arrest are a prerequisite of ceramide-induced toxicity in human arterial endothelial cells.
Topics: Apoptosis; Arteries; Cell Count; Cell Culture Techniques; Cell Division; Cyclin A; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; G1 Phase; Humans; Phosphoprotein Phosphatases; Sphingosine | 2001 |
Involvement of sphingomyelinase in insulin-induced phosphatidylinositol 3-kinase activation.
Topics: Animals; Cells, Cultured; Drug Interactions; Enzyme Activation; Enzyme Induction; Epidermis; Hexachlorocyclohexane; Insulin; Mice; Phosphatidylinositol 3-Kinases; Platelet Aggregation Inhibitors; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Cells, Cultured | 2001 |
Cell permeable exogenous ceramide reduces infarct size in spontaneously hypertensive rats supporting in vitro studies that have implicated ceramide in induction of tolerance to ischemia.
Topics: Animals; Brain Ischemia; Cell Membrane Permeability; Ceramides; In Vitro Techniques; Infarction, Middle Cerebral Artery; Injections, Intravenous; Injections, Intraventricular; Ischemic Preconditioning; Lipopolysaccharides; Male; Rats; Rats, Inbred SHR; Sphingosine; Tumor Necrosis Factor-alpha | 2001 |
Ceramide inhibits cell proliferation through Akt/PKB inactivation and decreases melanin synthesis in Mel-Ab cells.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Humans; Melanins; Melanocytes; Melanoma; Mice; Mitogen-Activated Protein Kinases; Monophenol Monooxygenase; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sphingosine | 2001 |
Ceramide inhibits lipopolysaccharide-mediated nitric oxide synthase and cyclooxygenase-2 induction in macrophages: effects on protein kinases and transcription factors.
Topics: Active Transport, Cell Nucleus; Animals; Biological Transport; Cell Line; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; I-kappa B Kinase; I-kappa B Proteins; Immunosuppressive Agents; Isoenzymes; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Serine-Threonine Kinases; Sphingosine; Transcription Factor AP-1; Transcription Factor RelA; Transcription Factors | 2001 |
Ceramide reduces endothelium-dependent vasodilation by increasing superoxide production in small bovine coronary arteries.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Animals; Arteries; Bradykinin; Calcimycin; Cattle; Ceramides; Citrulline; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Fluorescent Dyes; Free Radical Scavengers; In Vitro Techniques; Intracellular Fluid; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Sphingosine; Superoxide Dismutase; Superoxides; Vasodilation | 2001 |
Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells.
Topics: Actins; Animals; Catalysis; Cattle; Cells, Cultured; Chromaffin Cells; Enzyme Inhibitors; Exocytosis; Intracellular Fluid; Isoenzymes; Neurosecretory Systems; PC12 Cells; Phosphatidylinositol 4,5-Diphosphate; Phospholipase D; Protein Kinase C; Rats; Sphingosine | 2001 |
Effects of ceramide on aggrecanase activity in rabbit articular cartilage.
Topics: Aggrecans; Animals; Cartilage, Articular; Endopeptidases; Epitopes; Extracellular Matrix Proteins; Hexosamines; Interleukin-1; Kinetics; Lectins, C-Type; Male; Peptide Fragments; Proteoglycans; Rabbits; Sphingosine | 2001 |
Caspase-resistant vimentin suppresses apoptosis after photodynamic treatment with a silicon phthalocyanine in Jurkat cells.
Topics: Apoptosis; Caspases; Drug Resistance; Humans; Indoles; Jurkat Cells; Organosilicon Compounds; Oxidative Stress; Photochemotherapy; Photosensitizing Agents; Poly(ADP-ribose) Polymerases; Silanes; Sphingosine; Transfection; Vimentin | 2001 |
Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Enkephalins; Enzyme Inhibitors; Flavonoids; Gene Expression; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Protein Precursors; Protein Synthesis Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Stimulation, Chemical; Sulfonamides; Transcription Factor AP-1 | 2001 |
The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action.
Topics: Aequorin; Apoptosis; Calcium; Calcium-Binding Proteins; Calcium-Transporting ATPases; Calreticulin; Caspase 3; Caspases; Endoplasmic Reticulum; Enzyme Inhibitors; Genes, bcl-2; Genes, Reporter; Green Fluorescent Proteins; HeLa Cells; Humans; Kinetics; Luminescent Proteins; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Ribonucleoproteins; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sphingosine; Transfection | 2001 |
Angiostatin effects on endothelial cells mediated by ceramide and RhoA.
Topics: Angiostatins; Cell Membrane; Cells, Cultured; Cytoskeleton; Dose-Response Relationship, Drug; Endothelium, Vascular; Homeodomain Proteins; Humans; Immunoblotting; Kinetics; LIM-Homeodomain Proteins; Microscopy, Phase-Contrast; Nerve Tissue Proteins; Oligonucleotide Array Sequence Analysis; Peptide Fragments; Plasminogen; Protein Transport; rhoA GTP-Binding Protein; Signal Transduction; Sphingosine; Time Factors; Transcription Factors; Umbilical Veins | 2001 |
Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Ceramides; Cerebral Cortex; Down-Regulation; Enzyme Inhibitors; Fetus; Imidazoles; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyridines; RNA; Sphingomyelins; Sphingosine; Tumor Suppressor Protein p53; Up-Regulation | 2001 |
Uncoupling protein-3 mRNA up-regulation in C2C12 myotubes after etomoxir treatment.
Topics: Animals; Carnitine O-Palmitoyltransferase; Carrier Proteins; Cell Line; Ceramides; Enzyme Inhibitors; Epoxy Compounds; Ion Channels; Mice; Mitochondrial Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Uncoupling Protein 3; Up-Regulation | 2001 |
Propagation of the apoptotic signal by mitochondrial waves.
Topics: Animals; Apoptosis; Calcium; Caspases; Cell Line; Cell Membrane Permeability; Cytochrome c Group; Enzyme Activation; Enzyme Inhibitors; Ethanol; Mitochondria, Heart; Rats; Sarcoplasmic Reticulum; Signal Transduction; Sphingosine | 2001 |
Ceramide blocks PDGF-induced DNA synthesis in mesangial cells via inhibition of Akt kinase in the absence of apoptosis.
Topics: Animals; Apoptosis; Arabidopsis Proteins; Cell Division; Ceramides; DNA; Dose-Response Relationship, Drug; Glomerular Mesangium; Hydrogen Peroxide; Kinetics; Luciferases; Phosphatidylinositol 3-Kinases; Plant Proteins; Platelet-Derived Growth Factor; Potassium Channel Blockers; Potassium Channels; Precipitin Tests; Protein Binding; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingosine; Time Factors; Transfection | 2001 |
C2-ceramide signaling in glioma cells: synergistic enhancement of CD95-mediated, caspase-dependent apoptosis.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase Inhibitors; Caspases; Cytochrome c Group; Drug Synergism; Enzyme Activation; Fas Ligand Protein; fas Receptor; Humans; Immunoblotting; Membrane Glycoproteins; Microscopy, Electron; Mitochondria; Neuroglia; Poly(ADP-ribose) Polymerases; Signal Transduction; Sphingosine; Tumor Cells, Cultured | 2001 |
Ceramide inhibition of mammalian phospholipase D1 and D2 activities is antagonized by phosphatidylinositol 4,5-bisphosphate.
Topics: Bacterial Proteins; Catalytic Domain; Ceramides; Drug Interactions; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Isoenzymes; Liposomes; Phosphatidylinositol 4,5-Diphosphate; Phospholipase D; Plant Proteins; Protein Binding; Sphingosine | 2001 |
Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids.
Topics: Adenomatous Polyposis Coli Protein; Animals; beta Catenin; Cattle; Cell Division; Cell Nucleus; Colonic Neoplasms; Cytoskeletal Proteins; Cytosol; Diet; Humans; Intestinal Mucosa; Intestinal Neoplasms; Male; Mice; Mice, Inbred C57BL; Signal Transduction; Sphingolipids; Sphingosine; Trans-Activators; Tumor Cells, Cultured | 2001 |
Sphingomyelinase but not ceramide induces nitric oxide synthase expression in rat brain microglia.
Topics: Amyloid beta-Peptides; Animals; Carboxylic Acids; Cells, Cultured; Enzyme Inhibitors; Fumonisins; Gene Expression Regulation, Enzymologic; Lipopolysaccharides; Microglia; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peptide Fragments; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingomyelin Phosphodiesterase; Sphingosine | 2001 |
Role of palmitoyl-protein thioesterase in cell death: implications for infantile neuronal ceroid lipofuscinosis.
Topics: Antibiotics, Antineoplastic; Apoptosis; Chromones; Daunorubicin; Enzyme Inhibitors; Etoposide; Humans; Infant; Morpholines; Nerve Degeneration; Neuroblastoma; Neuronal Ceroid-Lipofuscinoses; Neurons; Nucleic Acid Synthesis Inhibitors; Sphingosine; Staurosporine; Thiolester Hydrolases; Transfection; Tumor Cells, Cultured | 2001 |
TNFalpha enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation.
Topics: Antimycin A; Calcium; Ceramides; DNA Damage; DNA, Single-Stranded; Electron Transport; Electron Transport Complex III; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Mitochondria; Sphingosine; Superoxides; tert-Butylhydroperoxide; Tumor Necrosis Factor-alpha; U937 Cells | 2001 |
Tumor necrosis factor-alpha induces stress fiber formation through ceramide production: role of sphingosine kinase.
Topics: Animals; cdc42 GTP-Binding Protein; Cell Line; Cytoskeletal Proteins; Cytoskeleton; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Paxillin; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein-Tyrosine Kinases; rac GTP-Binding Proteins; ras Proteins; Rats; rhoA GTP-Binding Protein; Sphingomyelin Phosphodiesterase; Sphingosine; Stress Fibers; Tumor Necrosis Factor-alpha; Tyrosine | 2001 |
The IL-15R alpha chain signals through association with Syk in human B cells.
Topics: Apoptosis; B-Lymphocyte Subsets; Calcium; Calcium Signaling; Cell Division; Enzyme Activation; Enzyme Precursors; Humans; Interleukin-15; Intracellular Signaling Peptides and Proteins; Isoenzymes; Jurkat Cells; K562 Cells; Lymphocyte Activation; Mutagenesis, Site-Directed; Oligonucleotides, Antisense; Phospholipase C gamma; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Interleukin-15; Receptors, Interleukin-2; Signal Transduction; Sphingosine; src Homology Domains; Syk Kinase; T-Lymphocyte Subsets; Tumor Cells, Cultured; Type C Phospholipases | 2001 |
Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest.
Topics: Animals; Aorta, Thoracic; Becaplermin; Cell Division; Cells, Cultured; Ceramides; Embryo, Mammalian; Humans; Insulin-Like Growth Factor I; Kinetics; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Rats; Recombinant Proteins; Sphingosine; Transfection | 2002 |
Adaptive concentrations of hydrogen peroxide suppress cell death by blocking the activation of SAPK/JNK pathway.
Topics: Adaptation, Physiological; Apoptosis; Enzyme Activation; Humans; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Kinase 7; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Oxidants; Signal Transduction; Sphingosine; Time Factors; U937 Cells | 2001 |
Ceramide and glucosamine antagonism of alternate signaling pathways regulating insulin- and osmotic shock-induced glucose transporter 4 translocation.
Topics: 3T3 Cells; Animals; Biological Transport; Enzyme Inhibitors; Glucosamine; Glucose Transporter Type 4; Hexosamines; Insulin; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Osmotic Pressure; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Receptor, Insulin; Signal Transduction; Sphingosine; Viral Proteins | 2002 |
Synergistic effect of interleukin-1alpha and ceramide analogue on production of prostaglandin E2 and F2alpha by endometrial stromal cells.
Topics: Cells, Cultured; Ceramides; Dinoprost; Dinoprostone; Drug Synergism; Endometrium; Female; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sialoglycoproteins; Sphingosine; Stromal Cells | 2001 |
Ceramide does not act as a general second messenger for ultraviolet-induced apoptosis.
Topics: Adenovirus E1A Proteins; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Breast Neoplasms; Caspase 1; Caspase 3; Caspase Inhibitors; Caspases; Ceramides; Enzyme Inhibitors; Female; Humans; Melanoma, Experimental; Mice; Protein Structure, Tertiary; Radiation Tolerance; Recombinant Fusion Proteins; Second Messenger Systems; Sphingosine; Transfection; Tumor Cells, Cultured; Ultraviolet Rays | 2002 |
Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells.
Topics: Animals; Apoptosis; Calcium; Caspase 3; Caspases; Cells, Cultured; Ceramides; Culture Media, Serum-Free; Cytochrome c Group; Hippocampus; Membrane Potentials; Microscopy, Confocal; Mitochondria; Nerve Tissue Proteins; Neurons; Sphingosine | 2002 |
Increased reactive oxygen species production down-regulates peroxisome proliferator-activated alpha pathway in C2C12 skeletal muscle cells.
Topics: Animals; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Epoxy Compounds; Fatty Acids; Flavonoids; Flow Cytometry; Mice; Muscle, Skeletal; NF-kappa B; Polymerase Chain Reaction; Protein Binding; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; RNA; RNA, Messenger; Sphingosine; Thiocarbamates; Time Factors; Transcription Factors; Triazenes | 2002 |
Membrane restructuring via ceramide results in enhanced solute efflux.
Topics: Bacillus cereus; Biochemical Phenomena; Biochemistry; Cell Membrane; Ceramides; Cholesterol; Lipid Bilayers; Lipids; Protein Structure, Tertiary; Signal Transduction; Spectrophotometry; Sphingosine; Time Factors | 2002 |
Cell-permeable ceramides preferentially inhibit coated vesicle formation and exocytosis in Chinese hamster ovary compared with Madin-Darby canine kidney cells by preventing the membrane association of ADP-ribosylation factor.
Topics: ADP-Ribosylation Factors; Animals; Capsid; Cell Line; Cell Membrane; CHO Cells; Cricetinae; Cytosol; Dogs; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Exocytosis; Golgi Apparatus; Immunoblotting; Phospholipase D; Protein Binding; Protein Kinase C; Rubella virus; Sphingosine; Time Factors | 2002 |
Transient relaxation of rat mesenteric microvessels by ceramides.
Topics: Animals; Ceramides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Mesentery; Microcirculation; Potassium Channel Blockers; Rats; Rats, Wistar; Sphingosine; Splanchnic Circulation; Vasodilation; Vasodilator Agents | 2002 |
Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D.
Topics: Cell Degranulation; Dose-Response Relationship, Drug; Humans; Lysophosphatidylcholines; Neutrophil Activation; Neutrophils; Oxidants; Phospholipase D; Phosphorylation; Protein Transport; Secretory Vesicles; Sphingosine; Superoxides | 2002 |
Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA.
Topics: Alkylation; Antineoplastic Agents, Alkylating; Apoptosis; bcl-2-Associated X Protein; Brain Neoplasms; DNA Damage; DNA, Neoplasm; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Genes, p53; Glioblastoma; Humans; Hydrogen Peroxide; Intercellular Signaling Peptides and Proteins; Neoplasm Proteins; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Sphingosine; Telomere; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ultraviolet Rays; Wnt Proteins; Zebrafish Proteins | 2002 |
Vesnarinone causes oxidative damage by inhibiting catalase function through ceramide action in myeloid cell apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Catalase; Cell Division; Ceramides; Drug Synergism; Enzyme Inhibitors; HL-60 Cells; Humans; Lipid Peroxidation; Oxidative Stress; Pyrazines; Quinolines; Sphingosine | 2002 |
C(2)-ceramide influences the expression and insulin-mediated regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 adipocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3T3 Cells; Adipocytes; Animals; Blotting, Western; Chromans; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Drug Interactions; Enzyme Inhibitors; Insulin; Insulin Resistance; Isoquinolines; Lipolysis; Mice; Receptors, Cytoplasmic and Nuclear; Sphingosine; Sulfonamides; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 2002 |
Ceramide and sphingosine rapidly induce apoptosis of murine mast cells supported by interleukin-3 and stem cell factor.
Topics: Animals; Apoptosis; Bone Marrow Cells; Carboxylic Acids; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Fumonisins; Interleukin-3; Male; Mast Cells; Mice; Mice, Inbred C57BL; Recombinant Proteins; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Stem Cell Factor | 2002 |
Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A.
Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Lithium; Neuroprotective Agents; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Sphingosine | 2002 |
Tumor necrosis factor-alpha, sphingomyelinase and ceramides activate tyrosine kinase, p21Ras and phosphatidylinositol 3-kinase: implications for glucose transport and insulin resistance.
Topics: Animals; Biological Transport; Ceramides; Enzyme Activation; Fibroblasts; Glucose; Insulin Resistance; Kinetics; Phosphatidylinositol 3-Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Rats; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Necrosis Factor-alpha | 2001 |
Heat shock and ceramide have different apoptotic pathways in radiation induced fibrosarcoma (RIF) cells.
Topics: Apoptosis; Cell Membrane; Fibrosarcoma; Heat-Shock Proteins; Heat-Shock Response; Kinetics; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Neoplasms, Radiation-Induced; Protein Biosynthesis; Proteins; Signal Transduction; Sphingosine | 2002 |
Involvement of phosphatidylinositol 3-kinase in nuclear translocation of protein kinase C zeta induced by C2-ceramide in rat hepatocytes.
Topics: Active Transport, Cell Nucleus; Androstadienes; Animals; Cell Membrane; Cell Nucleus; Cell Separation; Chromones; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hepatocytes; Isoenzymes; Male; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Rats; Rats, Wistar; Sphingosine; Subcellular Fractions; Wortmannin | 2002 |
HSP27 phosphorylation and interaction with actin-myosin in smooth muscle contraction.
Topics: Actins; Animals; Colon; Enzyme Inhibitors; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Myosins; Naphthalenes; Neoplasm Proteins; Phosphorylation; Precipitin Tests; Protein Kinase C; Rabbits; Sphingosine; Tropomyosin | 2002 |
Sphingoid bases and ceramide induce apoptosis in HT-29 and HCT-116 human colon cancer cells.
Topics: Apoptosis; Cell Cycle; Cell Division; Ceramides; Colonic Neoplasms; DNA Fragmentation; Dose-Response Relationship, Drug; Flow Cytometry; HT29 Cells; Humans; Microscopy, Fluorescence; Sphingosine; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins.
Topics: Adenylate Kinase; Animals; Apoptosis; Cell Membrane; Ceramides; Cytochrome c Group; Detergents; Electrophoresis, Polyacrylamide Gel; Electrophysiology; Fumarate Hydratase; Male; Mitochondria; Mitochondria, Liver; Permeability; Rats; Rats, Sprague-Dawley; Sphingosine; Time Factors | 2002 |
t-SNARE phosphorylation regulates endocytosis in yeast.
Topics: Endocytosis; Fungal Proteins; Ligands; Macromolecular Substances; Membrane Proteins; Membrane Transport Proteins; Phosphoprotein Phosphatases; Phosphorylation; Phosphotransferases; Pyridinium Compounds; Qa-SNARE Proteins; Quaternary Ammonium Compounds; R-SNARE Proteins; Receptors, Mating Factor; Receptors, Peptide; Saccharomyces cerevisiae Proteins; Sphingosine; Transcription Factors; Transport Vesicles; Yeasts | 2002 |
Control of ceramide-induced apoptosis by IGF-1: involvement of PI-3 kinase, caspase-3 and catalase.
Topics: Androstadienes; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Catalase; Enzyme Activation; Enzyme Inhibitors; HL-60 Cells; Humans; Insulin-Like Growth Factor I; Intracellular Membranes; Lipid Metabolism; Lipid Peroxidation; Membrane Potentials; Mitochondria; Oligopeptides; Oxidation-Reduction; Phosphatidylinositol 3-Kinases; Sphingosine; Wortmannin | 2002 |
Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes.
Topics: Adolescent; Cells, Cultured; Chromones; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Kinetics; Lysophospholipids; Melanins; Melanocytes; Microphthalmia-Associated Transcription Factor; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Monophenol Monooxygenase; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrones; Sphingosine; Transcription Factors | 2002 |
Decreased activity and enhanced nuclear export of CCAAT-enhancer-binding protein beta during inhibition of adipogenesis by ceramide.
Topics: 3T3 Cells; Active Transport, Cell Nucleus; Adipocytes; Animals; CCAAT-Enhancer-Binding Protein-alpha; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Cell Line; DNA; Humans; Mice; Receptors, Cytoplasmic and Nuclear; Sphingosine; Stem Cells; Transcription Factors; Transcriptional Activation | 2002 |
A non-IGF binding mutant of IGFBP-3 modulates cell function in breast epithelial cells.
Topics: Apoptosis; Breast; Cell Division; Cell Line; Dose-Response Relationship, Drug; Epithelial Cells; Female; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Mutation; Somatomedins; Sphingosine; Tumor Cells, Cultured | 2002 |
Effects of a non-IGF binding mutant of IGFBP-5 on cell death in human breast cancer cells.
Topics: Apoptosis; Breast Neoplasms; Cell Division; Cell Line; Dose-Response Relationship, Drug; Female; Humans; Insulin-Like Growth Factor Binding Protein 5; Insulin-Like Growth Factor I; Mutation; Somatomedins; Sphingosine; Tumor Cells, Cultured | 2002 |
Granulocyte colony-stimulating factor primes NADPH oxidase in neutrophils through translocation of cytochrome b(558) by gelatinase-granule release.
Topics: Cell Membrane; Cytochrome b Group; Cytosol; Dose-Response Relationship, Drug; Filgrastim; Gelatinases; Granulocyte Colony-Stimulating Factor; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Phospholipase D; Protein Transport; Recombinant Proteins; Secretory Vesicles; Sphingosine; Superoxides | 2002 |
Human placental lipid induces mitogenesis and melanogenesis in B16F10 melanoma cells.
Topics: Animals; Cell Division; Cell Size; Cell Survival; Humans; Lipids; Lysophospholipids; Melanins; Melanoma; Mice; Placental Extracts; Sphingolipids; Sphingosine; Tumor Cells, Cultured | 2002 |
Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis.
Topics: Animals; Animals, Newborn; Apoptosis; Brain; Cell Differentiation; Cell Membrane; Cell Survival; Cells, Cultured; Ceramides; Cerebellar Cortex; Cerebral Cortex; Dose-Response Relationship, Drug; Etoposide; Nerve Growth Factors; Neurons; Nucleic Acid Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Stress, Physiological; Up-Regulation | 2002 |
High levels of exogenous C2-ceramide promote morphological and biochemical evidences of necrotic features in thyroid follicular cells.
Topics: Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Cell Membrane Permeability; Cells, Cultured; Dose-Response Relationship, Drug; fas Receptor; Humans; Membrane Potentials; Membrane Proteins; Microscopy, Electron; Mitochondria; Necrosis; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Sphingosine; Thyroid Gland | 2002 |
Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway.
Topics: Adenoviridae; Animals; Apoptosis; Astrocytes; Cannabinoids; Cell Survival; Ceramides; Glioma; Immunohistochemistry; Male; Mitogen-Activated Protein Kinases; Neurons; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases; Sphingosine; Time Factors; Tumor Cells, Cultured | 2002 |
Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Caspase 3; Caspases; Chromosomal Proteins, Non-Histone; Cytochrome c Group; Embryo Loss; fas Receptor; Female; Hepatocytes; Inhibitor of Apoptosis Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Mitochondria; Neoplasm Proteins; Oxidative Phosphorylation; Pregnancy; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Sphingosine; Survivin; Transcription, Genetic; Up-Regulation | 2002 |
Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression.
Topics: Apoptosis; bcl-X Protein; Calpain; Caspases; Cell Death; Ceramides; Chromatin; DNA, Mitochondrial; Electron Transport; Electron Transport Complex II; Electron Transport Complex IV; Enzyme Activation; Enzyme Inhibitors; Glucose; Humans; Medulloblastoma; Mitochondria; Multienzyme Complexes; Oxidoreductases; Proto-Oncogene Proteins c-bcl-2; Pyruvic Acid; Sphingosine; Succinate Dehydrogenase; Transfection; Tumor Cells, Cultured | 2002 |
Phosphorylation of cardiac protein kinase B is regulated by palmitate.
Topics: Animals; Cells, Cultured; Fatty Acids; Glucose; Hypoglycemic Agents; In Vitro Techniques; Insulin; Muscle Fibers, Skeletal; Myocardial Contraction; Myocardium; Oxidation-Reduction; Palmitates; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Sphingosine | 2002 |
Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays.
Topics: Animals; Apoptosis; Cell Differentiation; Gene Expression Profiling; Genes; Neurons; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; PC12 Cells; Rats; Signal Transduction; Sphingosine | 2002 |
Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2.
Topics: Apoptosis; Cells, Cultured; Cytochalasin D; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation, Enzymologic; Hepatocytes; Humans; Imidazoles; Matrix Metalloproteinase 2; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Mitogen-Activated Protein Kinases; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; Sphingosine | 2002 |
Mitochondrial cytochrome c release precedes transmembrane depolarisation and caspase-3 activation during ceramide-induced apoptosis of Jurkat T cells.
Topics: Annexin A5; Apoptosis; Caspase 3; Caspases; Ceramides; Cytochrome c Group; Eukaryotic Cells; Fluorescein-5-isothiocyanate; Humans; Intracellular Membranes; Jurkat Cells; Membrane Potentials; Mitochondria; Phosphatidylserines; Sphingosine | 2002 |
C(2)-ceramide-induced circular smooth muscle cell contraction involves PKC-epsilon and p44/p42 MAPK activation in cat oesophagus. Mitogen-activated protein kinase.
Topics: Animals; Antibodies; Cats; Cells, Cultured; Dose-Response Relationship, Drug; Esophagus; Isoenzymes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle Contraction; Myocytes, Smooth Muscle; Peptides; Protein Kinase C; Protein Kinase C-epsilon; Signal Transduction; Sphingosine | 2002 |
Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells.
Topics: Amide Synthases; Apoptosis; Caspase Inhibitors; Caspases; Cathepsin D; Ceramides; Cytochrome c Group; DNA Fragmentation; Enzyme Inhibitors; Flow Cytometry; HT29 Cells; Humans; Immunoblotting; Lysosomes; Mitochondria; Morpholines; Nucleosomes; Sphingosine | 2002 |
Effects of C2-ceramide on the Malme-3M melanoma cell line.
Topics: Cell Cycle; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; HSP70 Heat-Shock Proteins; Humans; Melanins; Melanoma; Monophenol Monooxygenase; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Skin Neoplasms; Sphingosine; Tumor Cells, Cultured | 2002 |
Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts: role of ceramide.
Topics: Amidohydrolases; Animals; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Cell Line; Ceramidases; Ceramides; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Lysophospholipids; Mice; Mitogen-Activated Protein Kinases; Myristates; Osteoblasts; Osteocalcin; Phosphorylation; Propanolamines; Smad Proteins; Smad1 Protein; Sphingomyelin Phosphodiesterase; Sphingosine; Trans-Activators | 2002 |
Inhibition of CTP:phosphocholine cytidylyltransferase by C(2)-ceramide and its relationship to apoptosis.
Topics: Animals; Apoptosis; Choline-Phosphate Cytidylyltransferase; COS Cells; Enzyme Inhibitors; Haplorhini; Microscopy, Electron; Sphingosine | 2002 |
Synthetic ceramides induce growth arrest or apoptosis by altering cellular redox status.
Topics: Apoptosis; Buthionine Sulfoximine; Cell Division; Cells, Cultured; Ceramides; Dose-Response Relationship, Drug; Glutathione; Humans; Jurkat Cells; Leukemia, T-Cell; Mitochondria; Monocytes; Oxidation-Reduction; Peroxides; Reactive Oxygen Species; Rotenone; Sphingosine | 2002 |
Identification of platelet-activating factor acetylhydrolase II in human skin.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Apoptosis; Biological Transport; Cells, Cultured; Fluorescent Antibody Technique; Humans; Phospholipases A; Phospholipases A2; Phospholipids; Skin; Sphingosine; tert-Butylhydroperoxide; Ultraviolet Rays | 2002 |
Slight impairment of Na+,K+-ATPase synergistically aggravates ceramide- and beta-amyloid-induced apoptosis in cortical neurons.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Cell Death; Cells, Cultured; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Fetus; Intracellular Fluid; Mice; Neocortex; Neurons; Peptide Fragments; Sodium-Potassium-Exchanging ATPase; Sphingosine | 2002 |
Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway.
Topics: Animals; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Caspases; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Humans; Kinetics; Mutation; Neurons; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingosine; Tumor Cells, Cultured | 2002 |
Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calcium; Cells, Cultured; Endoplasmic Reticulum; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; HeLa Cells; Homeostasis; Humans; Ion Channels; Ion Transport; Mitochondria; Muscle Fibers, Skeletal; Porins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Recombinant Fusion Proteins; Sphingosine; Voltage-Dependent Anion Channels | 2002 |
Gold sodium thiomalate (GSTM) inhibits lipopolysaccharide stimulated tumor necrosis factor-alpha through ceramide pathway.
Topics: Adult; Antirheumatic Agents; Cells, Cultured; Ceramides; Female; Gold Sodium Thiomalate; Humans; Leukocytes, Mononuclear; Lipopolysaccharides; Male; NF-kappa B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sphingosine; Tumor Necrosis Factor-alpha | 2002 |
Altered sphingolipid metabolism in N-(4-hydroxyphenyl)-retinamide-resistant A2780 human ovarian carcinoma cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Drug Resistance, Neoplasm; Female; Fenretinide; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Ovarian Neoplasms; Sphingolipids; Sphingosine; Tumor Cells, Cultured | 2003 |
Signaling events mediating activation of brain ethanolamine plasmalogen hydrolysis by ceramide.
Topics: Animals; Brain; Caspase 3; Caspase Inhibitors; Caspases; Ceramides; Endothelin-1; Enzyme Inhibitors; Flavonoids; Hydrolysis; Male; Okadaic Acid; Phospholipases A; Phospholipases A2; Phospholipid Ethers; Phosphoprotein Phosphatases; Plasmalogens; Protein Phosphatase 2; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine | 2003 |
Cellular regulation of sodium-calcium exchange.
Topics: Animals; Axons; Calcium; Calcium Channels; CHO Cells; Cricetinae; Cytosol; Decapodiformes; Depsipeptides; Heart; Marine Toxins; Mitochondria; Mutagenesis, Site-Directed; Myocardial Contraction; Oxazoles; Peptides, Cyclic; Recombinant Proteins; Sodium; Sodium Channels; Sodium-Calcium Exchanger; Sphingosine; Transfection | 2002 |
Ceramide increases oxidative damage due to inhibition of catalase by caspase-3-dependent proteolysis in HL-60 cell apoptosis.
Topics: Apoptosis; Blotting, Northern; Blotting, Western; Caspase 3; Caspase 6; Caspase 8; Caspase 9; Caspases; Catalase; Ceramides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Gene Deletion; HL-60 Cells; Humans; Hydrogen Peroxide; Oxidative Stress; Oxygen; Peroxidase; Precipitin Tests; Reactive Oxygen Species; RNA; RNA, Messenger; Sphingosine; Thiobarbituric Acid Reactive Substances; Time Factors | 2003 |
Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Cell Line; Cell Separation; Ceramides; DNA, Complementary; Dose-Response Relationship, Drug; Doxycycline; Drug Resistance, Neoplasm; Enzyme Activation; Flow Cytometry; Glucosyltransferases; HL-60 Cells; Humans; Leukemia; Middle Aged; Neoplasms; Propidium; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Transfection; Transferases (Other Substituted Phosphate Groups) | 2003 |
Ceramide increases mitochondrial free calcium levels via caspase 8 and Bid: role in initiation of cell death.
Topics: Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Calcium; Carrier Proteins; Caspase 8; Caspase 9; Caspases; Cell Differentiation; Ceramides; Cytochrome c Group; Endoplasmic Reticulum; Mitochondria; Nerve Growth Factor; Neurons; PC12 Cells; Rats; Reactive Oxygen Species; Sphingosine | 2003 |
Insulin or bFGF and C2 ceramide increase newborn rat retinal ganglion cell survival rate.
Topics: Animals; Animals, Newborn; Carbazoles; Cell Separation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblast Growth Factor 2; Indole Alkaloids; Insulin; Okadaic Acid; Rats; Retinal Ganglion Cells; Signal Transduction; Sphingosine | 2003 |
Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function.
Topics: Adult; Aged; Apoptosis; Cell Division; Cells, Cultured; Cytochrome c Group; Cytosol; DNA Fragmentation; Fatty Acids, Monounsaturated; Fumonisins; Gene Expression; Genes, bcl-2; Glucose; Humans; In Situ Nick-End Labeling; Insulin; Insulin Secretion; Islets of Langerhans; Middle Aged; Mitochondria; Oleic Acid; Palmitic Acid; Sphingosine | 2003 |
Potentiation of lipopolysaccharide-inducible cyclooxygenase 2 expression by C2-ceramide via c-Jun N-terminal kinase-mediated activation of CCAAT/enhancer binding protein beta in macrophages.
Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Protein-delta; CCAAT-Enhancer-Binding Proteins; Cell Nucleus; Cells, Cultured; Collagen Type I; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; DNA; Drug Synergism; Enzyme Inhibitors; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Signal Transduction; Sphingosine; Transcription Factor AP-1; Transcription Factors; Transfection; Tumor Necrosis Factor-alpha | 2003 |
Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis.
Topics: Animals; Apoptosis; Carcinogens; Cell Communication; Cell Line; Cell Transformation, Neoplastic; Ceramides; Dose-Response Relationship, Drug; Epithelial Cells; Gap Junctions; Liver; Molecular Structure; Rats; Rats, Inbred F344; Sphingosine; Structure-Activity Relationship | 2003 |
Hippocampal programmed cell death after status epilepticus: evidence for NMDA-receptor and ceramide-mediated mechanisms.
Topics: Age Factors; Animals; Apoptosis; Ceramides; Disease Models, Animal; Dizocilpine Maleate; DNA Fragmentation; Dose-Response Relationship, Drug; Hippocampus; Injections, Intraperitoneal; Kainic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sphingosine; Status Epilepticus | 2003 |
BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis.
Topics: Animals; Apoptosis; Arachidonic Acid; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Calcium; Calcium Signaling; Calcium-Transporting ATPases; Cell Fractionation; Cell Line, Transformed; Cells, Cultured; Endoplasmic Reticulum; Histamine; Hydrogen Peroxide; Ionomycin; Membrane Proteins; Mice; Mice, Knockout; Microscopy, Confocal; Microscopy, Immunoelectron; Mitochondria; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sphingosine | 2003 |
Synthesis of non-natural C2-homo-ceramide and its apoptotic activity against HL-60 cells.
Topics: Antineoplastic Agents; Apoptosis; Enzyme Inhibitors; HL-60 Cells; Humans; Sphingosine; Stereoisomerism; Structure-Activity Relationship | 2003 |
Ceramide attenuates high glucose-induced cardiac contractile abnormalities in cultured adult rat ventricular myocytes.
Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Enzyme Inhibitors; Glucose; Heart Ventricles; Male; Morpholines; Muscle Cells; Myocardial Contraction; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Sphingosine | 2002 |
Mitochondrial effects with ceramide-induced cardiac apoptosis are different from those of palmitate.
Topics: Animals; Antimycin A; Apoptosis; Cells, Cultured; Chick Embryo; Cyclosporine; Electron Transport; Fluorescent Dyes; Heart; Membrane Potentials; Mitochondria, Heart; Myocardium; Organic Chemicals; Palmitic Acid; Rotenone; Sphingosine | 2003 |
Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Apoptosis; Blotting, Western; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; Intracellular Membranes; Membrane Potentials; Mice; Microscopy, Confocal; Mitochondria; Neurons; Oxidative Stress; Phosphorylation; Precipitin Tests; Pyruvic Acid; Reactive Oxygen Species; Sodium-Potassium-Exchanging ATPase; Sphingosine; Staurosporine; Succinic Acid; Time Factors | 2003 |
Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3beta, and induction of the mitochondrial-dependent intrinsic caspase pathway.
Topics: Animals; Apoptosis; bcl-Associated Death Protein; Carrier Proteins; Caspases; Cells, Cultured; Cerebral Cortex; DNA-Binding Proteins; Enzyme Inhibitors; Forkhead Transcription Factors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Mitochondria; Nerve Tissue Proteins; Neurons; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Sphingosine; Transcription Factors | 2003 |
Positive inotropic effect of ceramide in adult ventricular myocytes: mechanisms dissociated from its reduction in Ca2+ influx.
Topics: Age Factors; Animals; Caffeine; Calcium; Cardiotonic Agents; Enzyme Inhibitors; Heart Ventricles; Male; Myocardial Contraction; Myocytes, Cardiac; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum; Sphingosine; Ventricular Function, Left | 2003 |
Characterization of C2-ceramide-resistant HL-60 subline (HL-CR): involvement of PKC delta in C2-ceramide resistance.
Topics: Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Division; Cell Membrane; Cholecalciferol; Drug Resistance; Eukaryotic Cells; Gene Expression Regulation, Enzymologic; HL-60 Cells; Humans; Isoenzymes; Protein Kinase C; Protein Kinase C-delta; Protein Transport; Sphingosine; Tetradecanoylphorbol Acetate; Tretinoin | 2003 |
Mechanisms involved in exogenous C2- and C6-ceramide-induced cancer cell toxicity.
Topics: Apoptosis; Caspase 3; Caspases; Cell Survival; Ceramides; Cytochrome c Group; Enzyme Activation; Enzyme Inhibitors; Humans; NF-kappa B; Poly(ADP-ribose) Polymerases; Sphingosine; Tumor Cells, Cultured | 2003 |
C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis.
Topics: Animals; Apoptosis; Blotting, Western; Cell Survival; Ceramides; Cerebral Cortex; Culture Media, Serum-Free; Culture Techniques; DNA-Binding Proteins; Early Growth Response Protein 1; Embryo, Mammalian; Enzyme Inhibitors; Female; Gene Expression Regulation; Green Fluorescent Proteins; Imidazoles; Immediate-Early Proteins; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Luminescent Proteins; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pregnancy; Proteins; Proto-Oncogene Proteins c-jun; Pyridines; Sphingosine; Subcellular Fractions; Time Factors; Transcription Factors; Transfection | 2003 |
Caspase-3-dependent reactivation of latent herpes simplex virus type 1 in sensory neuronal cultures.
Topics: Adenoviridae; Animals; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Colforsin; Cysteine Proteinase Inhibitors; Enzyme Activation; Ganglia, Spinal; Genetic Vectors; Herpesvirus 1, Human; Nerve Growth Factors; Nerve Tissue Proteins; Neurons, Afferent; Oligopeptides; Rats; Recombinant Fusion Proteins; Sphingosine; Tetradecanoylphorbol Acetate; Virus Activation; Virus Latency | 2003 |
Apoptotic activities of C2-ceramide and C2-dihydroceramide homologues against HL-60 cells.
Topics: Apoptosis; Caspase 3; Caspases; Ceramides; DNA Fragmentation; Dose-Response Relationship, Drug; HL-60 Cells; Humans; Kinetics; Poly Adenosine Diphosphate Ribose; Sphingosine; Structure-Activity Relationship | 2003 |
C2-ceramide inhibits LPS-induced nitric oxide production in RAW 264.7 macrophage cells through down-regulating the activation of Akt.
Topics: Animals; Cell Line; Down-Regulation; Enzyme Inhibitors; Escherichia coli; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sphingosine; Transfection | 2003 |
Prevalence of necrosis in C2-ceramide-induced cytotoxicity in NB16 neuroblastoma cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Survival; Enzyme Inhibitors; Humans; Necrosis; Neuroblastoma; Sphingosine; Tumor Cells, Cultured | 2003 |
Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1.
Topics: Animals; Apolipoprotein A-I; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Biological Transport, Active; Cell Line; Cell Membrane; Cells, Cultured; CHO Cells; Cholesterol; Cricetinae; HeLa Cells; Humans; Mice; Muscle, Smooth, Vascular; Recombinant Fusion Proteins; Sphingosine | 2003 |
p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD.
Topics: Animals; Apoptosis; Camptothecin; cdc42 GTP-Binding Protein; Cell Survival; CHO Cells; COS Cells; Cricetinae; Cyclic AMP-Dependent Protein Kinases; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Galactose; Genetic Complementation Test; Glutathione Transferase; Immunoblotting; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase Kinases; Microscopy, Fluorescence; Mitochondria; Models, Biological; Mutation; p21-Activated Kinases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Serine-Threonine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sphingosine; Subcellular Fractions; Transfection | 2003 |
Analysis of intracellular distribution and apoptosis involvement of the Ufd1l gene product by over-expression studies.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Apoptosis; Chlorocebus aethiops; Cloning, Molecular; COS Cells; Gene Expression Regulation; Genetic Vectors; Green Fluorescent Proteins; Humans; Inhibitor of Apoptosis Proteins; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Intracellular Space; Luminescent Proteins; Mice; Microscopy, Fluorescence; NIH 3T3 Cells; Proteins; Recombinant Fusion Proteins; Sphingosine; Transfection; Tumor Cells, Cultured; Viral Proteins | 2003 |
Enlargement and contracture of C2-ceramide channels.
Topics: Biophysical Phenomena; Biophysics; Cytochromes c; Edetic Acid; Electrophysiology; Ion Channels; Ions; Kinetics; Lanthanum; Lipids; Membrane Potentials; Membranes, Artificial; Models, Molecular; Sphingosine; Time Factors | 2003 |
Decreased c-Myc expression and its involvement in X-ray-induced apoptotic cell death of human T-cell leukaemia cell line MOLT-4.
Topics: Anisomycin; Apoptosis; Cell Line, Tumor; Cell Survival; Humans; Leukemia, T-Cell; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-myc; RNA, Messenger; Sphingosine; Tumor Suppressor Protein p53; X-Rays | 2003 |
Ceramide inhibition of phospholipase D and its relationship to RhoA and ARF1 translocation in GTP gamma S-stimulated polymorphonuclear leukocytes.
Topics: ADP-Ribosylation Factor 1; Bacterial Proteins; Cell Membrane; Cytosol; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Lactoferrin; Neutrophils; Phospholipase D; Phosphorylation; rhoA GTP-Binding Protein; Sphingosine; Streptolysins | 2004 |
Prolactin acts as a potent survival factor against C2-ceramide-induced apoptosis in human granulosa cells.
Topics: Apoptosis; Cell Count; Cell Survival; Cells, Cultured; Corpus Luteum; Dose-Response Relationship, Drug; Female; Flow Cytometry; Granulosa Cells; Humans; Progesterone; Prolactin; Sphingosine | 2003 |
Commitment to apoptosis by ceramides depends on mitochondrial respiratory function, cytochrome c release and caspase-3 activation in Hep-G2 cells.
Topics: Apoptosis; Caspase 3; Caspases; Cell Line; Cell Line, Tumor; Cell Nucleus; Cell Survival; Ceramides; Coloring Agents; Cytochromes c; DNA; DNA Fragmentation; Dose-Response Relationship, Drug; Electron Transport; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Flow Cytometry; Humans; Microscopy, Fluorescence; Mitochondria; Reactive Oxygen Species; Sphingosine; Tetrazolium Salts; Thiazoles; Time Factors | 2003 |
(3Z)-2-Acetylamino-3-octadecen-1-ol as a potent apoptotic agent against HL-60 cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Death; HL-60 Cells; Humans; Oleic Acids; Sphingosine; Stereoisomerism | 2004 |
Ceramide pathways modulate ethanol-induced cell death in astrocytes.
Topics: Amidohydrolases; Animals; Animals, Newborn; Astrocytes; Brain; Carrier Proteins; Caspase 3; Caspases; Cell Death; Cells, Cultured; Central Nervous System Depressants; Ceramidases; Chromatography, High Pressure Liquid; Coatomer Protein; Colorimetry; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Ethanol; Immunoblotting; In Vitro Techniques; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Myelin Basic Protein; p38 Mitogen-Activated Protein Kinases; Palmitates; Precipitin Tests; Proto-Oncogene Proteins c-jun; rab5 GTP-Binding Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingomyelin Phosphodiesterase; Sphingosine; Time Factors | 2003 |
Inhibition of IL-10 receptor function in alveolar macrophages by Toll-like receptor agonists.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antigens, Differentiation; Bronchoalveolar Lavage Fluid; CpG Islands; DNA-Binding Proteins; Dose-Response Relationship, Immunologic; Down-Regulation; Immunosuppressive Agents; Interleukin-10; Ligands; Lipopolysaccharides; Macrophage Activation; Macrophages, Alveolar; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88; Oligodeoxyribonucleotides; Receptors, Cell Surface; Receptors, Immunologic; Receptors, Interleukin; Receptors, Interleukin-10; Signal Transduction; Sphingosine; STAT3 Transcription Factor; Teichoic Acids; Toll-Like Receptor 2; Toll-Like Receptor 4; Toll-Like Receptors; Trans-Activators | 2004 |
Ceramide influences neurite outgrowth and neuroblastoma cell apoptosis regulated by novel protein kinase C isoforms.
Topics: Apoptosis; Cell Count; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Isoenzymes; Neurites; Neuroblastoma; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Transport; rho-Associated Kinases; Sphingosine; Transfection; Tretinoin | 2004 |
Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell death.
Topics: Antineoplastic Agents; beta-D-Galactoside alpha 2-6-Sialyltransferase; Caspase 3; Caspases; Cell Death; Cell Line, Tumor; Cell Membrane; Cell Survival; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Glioma; Glycoconjugates; Glycosylation; Humans; Morpholines; N-Acetylglucosaminyltransferases; Oligosaccharides; Sialyltransferases; Sphingosine; Staurosporine; Transfection | 2004 |
Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells.
Topics: Autophagy; Cell Death; Cell Line, Tumor; G2 Phase; Glioma; Humans; Intracellular Membranes; Membrane Potentials; Membrane Proteins; Mitochondria; Mitosis; Proto-Oncogene Proteins; Sphingosine; Transfection | 2004 |
Prolactin acts as a potent survival factor for human breast cancer cell lines.
Topics: Apoptosis; Breast Neoplasms; Cell Survival; Combined Modality Therapy; Enzyme Inhibitors; Female; Humans; Prolactin; Sphingosine; Tumor Cells, Cultured | 2004 |
Enhancement of C2-ceramide antitumor activity by small interfering RNA on X chromosome-linked inhibitor of apoptosis protein in resistant human glioma cells.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Inducing Factor; Cell Culture Techniques; Cell Line, Tumor; Chromosomes, Human, X; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Flavoproteins; Glioma; Humans; Membrane Proteins; Proteins; RNA, Small Interfering; Sphingosine; X-Linked Inhibitor of Apoptosis Protein | 2004 |
Reduced levels of the adenomatous polyposis coli (APC) protein are associated with ceramide-induced apoptosis of colon cancer cells.
Topics: Adenomatous Polyposis Coli Protein; Apoptosis; Cell Cycle; Cell Proliferation; Ceramides; Chlorides; Colonic Neoplasms; Genes, p53; Humans; Sphingosine; Tumor Cells, Cultured; Zinc Compounds | 2004 |
Nitric oxide acts on the mitochondria and protects human endothelial cells from apoptosis.
Topics: Apoptosis; Arthritis, Rheumatoid; Caspases; Cell Division; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Etoposide; Humans; Leupeptins; Mitochondria; Nitric Oxide; Nitric Oxide Donors; S-Nitroso-N-Acetylpenicillamine; Sphingosine | 2004 |
Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert.
Topics: 3T3 Cells; Animals; Apoptosis; Cell Line, Transformed; Cell Survival; HL-60 Cells; Humans; Mice; Models, Biological; Sphingosine; U937 Cells | 2004 |
Synergistic effect of interleukin (IL)-1alpha and ceramide analogue on the production of IL-6, IL-8, and macrophage colony-stimulating factor by endometrial stromal cells.
Topics: Adult; Cells, Cultured; Ceramides; Endometrium; Female; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Interleukin-6; Interleukin-8; Macrophage Colony-Stimulating Factor; Sialoglycoproteins; Sphingosine; Stromal Cells | 2004 |
Volume-sensitive chloride channels (ICl,vol) mediate doxorubicin-induced apoptosis through apoptotic volume decrease in cardiomyocytes.
Topics: Animals; Annexin A5; Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Cell Size; Cells, Cultured; Chloride Channels; Doxorubicin; Heart Ventricles; Male; Myocytes, Cardiac; Osmotic Pressure; Patch-Clamp Techniques; Rabbits; Sphingosine; Time Factors | 2004 |
Mitochondrial dysfunction is a primary event in renal cell oxalate toxicity.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Caspases; Cell Line; Dogs; Enzyme Activation; Enzyme Inhibitors; Intracellular Membranes; Kidney; Lipid Peroxidation; Lysophosphatidylcholines; Membrane Potentials; Mitochondria; Oxalates; Phospholipases A; Phospholipases A2; Reactive Oxygen Species; Sphingosine | 2004 |
The mitochondrion--an organelle commonly involved in programmed cell death in Arabidopsis thaliana.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Arabidopsis; Arabidopsis Proteins; Flow Cytometry; Gene Expression Regulation, Plant; Light; Membrane Potentials; Mitochondria; Oxidoreductases; Plant Leaves; Protoplasts; Protoporphyrins; Sphingosine | 2004 |
High sensitivity of fibroblast cell lines derived from LEC rats to heat treatment.
Topics: Animals; Anthracenes; Apoptosis; Cell Line; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Fibroblasts; Flow Cytometry; Hot Temperature; HSP70 Heat-Shock Proteins; Imidazoles; Immunoblotting; Pyridines; Rats; Rats, Inbred LEC; Sphingosine; Time Factors | 2004 |
Enhancement of radiosensitivity by combined ceramide and dimethylsphingosine treatment in lung cancer cells.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Carcinoma, Lewis Lung; Caspases; Cell Line, Tumor; Cell Survival; Gene Expression; Lung Neoplasms; Mice; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Radiation Tolerance; Radiation-Sensitizing Agents; Sphingosine | 2004 |
Opposite regulation of the mitochondrial apoptotic pathway by C2-ceramide and PACAP through a MAP-kinase-dependent mechanism in cerebellar granule cells.
Topics: Animals; Animals, Newborn; bcl-2-Associated X Protein; Benzimidazoles; Blotting, Western; Carbocyanines; Caspase 3; Caspase 9; Caspases; Cells, Cultured; Cerebellum; Cytochromes c; Cytosol; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Fluorescent Antibody Technique; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Membrane Potentials; Mice; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Neurological; Nerve Growth Factors; Neurons; Neuropeptides; Neurotransmitter Agents; Pituitary Adenylate Cyclase-Activating Polypeptide; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sphingosine; Time Factors | 2004 |
Ceramide enhances acrosomal exocytosis triggered by calcium and the calcium ionophore A23187 in boar spermatozoa.
Topics: Acrosome; Acrosome Reaction; Amidohydrolases; Animals; Calcimycin; Calcium; Cell Survival; Ceramidases; Ceramides; Culture Media; Dose-Response Relationship, Drug; Embryo, Mammalian; Exocytosis; Ionophores; Male; Specimen Handling; Sperm Motility; Spermatozoa; Sphingosine; Swine; Temperature; Time Factors | 2004 |
Pituitary adenylate cyclase-activating polypeptide prevents the effects of ceramides on migration, neurite outgrowth, and cytoskeleton remodeling.
Topics: Amino Acid Chloromethyl Ketones; Animals; Cell Movement; Cells, Cultured; Cerebellum; Cysteine Proteinase Inhibitors; Cytoskeleton; Microscopy, Video; Nerve Growth Factors; Nerve Tissue Proteins; Neurites; Neurons; Neuropeptides; Neurotransmitter Agents; Phosphoproteins; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Sphingosine; tau Proteins | 2005 |
Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate.
Topics: Angiogenesis Inhibitors; Animals; DNA, Complementary; Embryo, Nonmammalian; Endothelium, Vascular; Eye Abnormalities; Humans; Lysophospholipids; Magnesium; Neuropilin-1; Oligonucleotides, Antisense; Sphingomyelin Phosphodiesterase; Sphingosine; Thalidomide; Umbilical Veins; Vascular Endothelial Growth Factor Receptor-2; Zebrafish | 2005 |
The 70 kilodalton heat shock protein is an inhibitor of apoptosis in prostate cancer.
Topics: Animals; Apoptosis; Caspase Inhibitors; Cell Line, Tumor; Cell Survival; Cell-Free System; DNA Fragmentation; DNA, Antisense; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heat-Shock Proteins; Heat-Shock Response; Hot Temperature; HSP70 Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Humans; In Situ Nick-End Labeling; Male; Mice; Prostatic Neoplasms; Quercetin; Serpins; Sphingosine; Viral Proteins | 2004 |
Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cells.
Topics: ADAM Proteins; ADAM17 Protein; Amyloid Precursor Protein Secretases; Animals; Apoptosis; Ascitic Fluid; Aspartic Acid Endopeptidases; Binding, Competitive; Cell Hypoxia; Cell Line, Tumor; Cell Movement; CHO Cells; Cricetinae; Cricetulus; Cytoplasmic Vesicles; Endopeptidases; Extracellular Signal-Regulated MAP Kinases; Female; HeLa Cells; Humans; Metalloendopeptidases; Neural Cell Adhesion Molecule L1; Ovarian Neoplasms; Phosphorylation; Solubility; Sphingosine | 2005 |
Ceramides induce programmed cell death in Arabidopsis cells in a calcium-dependent manner.
Topics: Apoptosis; Arabidopsis; Calcium; Calcium Signaling; Cells, Cultured; Ceramides; In Situ Nick-End Labeling; Reactive Oxygen Species; Sphingosine | 2005 |
Induction of apoptosis in chicken oviduct cells by C2-ceramide.
Topics: Animals; Annexin A5; Apoptosis; bcl-X Protein; Caspases; Chickens; Enzyme Inhibitors; Female; Oviducts; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Sphingosine | 2005 |
Molecular associations and surface-active properties of short- and long-N-acyl chain ceramides.
Topics: Ceramides; Phospholipids; Sphingosine; Surface-Active Agents; Time Factors; Water | 2005 |
Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines.
Topics: Androstadienes; Animals; Apoptosis; Brain Neoplasms; Caspase 3; Caspase 8; Caspases; Cell Division; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Humans; Membrane Microdomains; Oligodendroglioma; PC12 Cells; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Protein Kinase Inhibitors; PTEN Phosphohydrolase; Rats; Sphingosine; Staurosporine; Transfection; Tumor Suppressor Proteins; Wortmannin | 2005 |
Metabolic activity: a novel indicator of neuronal survival in the murine dopaminergic cell line CAD.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase Inhibitors; Caspases; Cell Line; Cell Survival; Cysteine Proteinase Inhibitors; Dopamine; Energy Metabolism; Mice; Neurons; Neuroprotective Agents; Neurotrophin 3; Sphingosine | 2005 |
Death or survival: membrane ceramide controls the fate and activation of antigen-specific T-cells depending on signal strength and duration.
Topics: Animals; Apoptosis; B-Lymphocytes; Caspase 3; Caspases; Cell Membrane; Cell Survival; DNA Fragmentation; fas Receptor; Humans; Interleukin-2; Kv1.3 Potassium Channel; Lymphocyte Activation; Membrane Potentials; Mice; Receptors, Antigen, T-Cell; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; T-Lymphocytes, Helper-Inducer; Time Factors | 2006 |
Ceramide- and ERK-dependent pathway for the activation of CCAAT/enhancer binding protein by interleukin-1beta in hepatocytes.
Topics: Active Transport, Cell Nucleus; Acute-Phase Proteins; Animals; Biological Transport; CCAAT-Enhancer-Binding Proteins; Cell Nucleus; Ceramides; Collagen; Cytosol; DNA; Dose-Response Relationship, Drug; Drug Combinations; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hepatocytes; Immunoblotting; Inflammation; Interleukin-1; Laminin; Liver; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Oligonucleotides; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Protein Transport; Proteoglycans; Rats; Rats, Inbred F344; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine | 2005 |
Ceramide decreases surfactant protein B gene expression via downregulation of TTF-1 DNA binding activity.
Topics: DNA; Down-Regulation; Gene Expression Regulation; Hepatocyte Nuclear Factor 3-alpha; Humans; Lung Neoplasms; Lysophospholipids; Nuclear Proteins; Promoter Regions, Genetic; Protein Kinases; Pulmonary Surfactant-Associated Protein B; RNA, Messenger; Signal Transduction; Sphingosine; Thyroid Nuclear Factor 1; Transcription Factors; Tumor Cells, Cultured | 2006 |
C2-ceramide exhibits antiproliferative activity and potently induces apoptosis in endometrial carcinoma.
Topics: Apoptosis; Carcinoma; Cell Cycle; Cell Proliferation; Cell Transformation, Neoplastic; Endometrial Neoplasms; Enzyme Inhibitors; Female; Humans; Phenotype; Sphingosine; Tumor Cells, Cultured | 2005 |
C2-ceramide induces vasodilation in phenylephrine-induced pre-contracted rat thoracic aorta: role of RhoA/Rho-kinase and intracellular Ca2+ concentration.
Topics: Animals; Aorta, Thoracic; Calcium; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Muscle, Smooth, Vascular; Phenylephrine; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; rho-Associated Kinases; Sphingosine; Tumor Necrosis Factor-alpha; Vasoconstriction; Vasodilation | 2005 |
Regulation of Ca2+ signalling and Ca2+-mediated cell death by the transcriptional coactivator PGC-1alpha.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Apoptosis; Calcium; Calcium Channels; Calcium Signaling; Enzyme Inhibitors; Heat-Shock Proteins; HeLa Cells; Histamine; Homeostasis; Humans; Inositol 1,4,5-Trisphosphate Receptors; Ion Channels; Membrane Transport Proteins; Mitochondria, Muscle; Mitochondrial Proteins; Mitochondrial Swelling; Muscle Fibers, Skeletal; Nuclear Respiratory Factor 1; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Receptors, Cytoplasmic and Nuclear; Sphingosine; Transcription Factors; Transfection; Uncoupling Protein 2 | 2006 |
Involvement of the ubiquitin-mediated proteolytic system in the signaling pathway induced by ceramide in primary astrocyte cultures.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Astrocytes; Cell Nucleus; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; I-kappa B Proteins; NF-kappa B; Proteasome Endopeptidase Complex; Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; RNA, Messenger; Signal Transduction; Sphingosine; Ubiquitin; Up-Regulation | 2005 |
Ceramide-induced preconditioning involves reactive oxygen species.
Topics: Animals; Antioxidants; Catalase; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Rats; Rats, Long-Evans; Reactive Oxygen Species; Sphingosine; Superoxide Dismutase; Tiopronin | 2006 |
Bcl-2 but not clusterin/apolipoprotein J protected human diploid fibroblasts and immortalized keratinocytes from ceramide-induced apoptosis: role of p53 in the ceramide response.
Topics: Apoptosis; Cell Line, Transformed; Clusterin; Cyclin-Dependent Kinase Inhibitor p21; Diploidy; Down-Regulation; Fibroblasts; Humans; Keratinocytes; Mutation; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sphingosine; Tumor Suppressor Protein p53 | 2006 |
9-O-acetyl GD3 protects tumor cells from apoptosis.
Topics: Acetylation; Antibiotics, Antineoplastic; Apoptosis; Cell Line, Tumor; Daunorubicin; Enzyme Inhibitors; Gangliosides; Humans; Jurkat Cells; Leukemia, T-Cell; Melanoma; Sphingosine; Time Factors | 2006 |
Amyloid beta peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes.
Topics: Amyloid beta-Peptides; Animals; Apoptosis Regulatory Proteins; Blotting, Western; Brain; Cell Death; Cell Fractionation; Cell Nucleus; Cytosol; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; MAP Kinase Kinase 4; Neuropeptides; Oligodendroglia; Phosphorylation; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Sphingomyelin Phosphodiesterase; Sphingosine; Tetrazolium Salts; Thiazoles; Time Factors; Transcription Factor AP-1 | 2006 |
Ceramide is a mediator of apoptosis in retina photoreceptors.
Topics: Animals; Apoptosis; Ceramides; Cycloserine; Docosahexaenoic Acids; Enzyme Inhibitors; Fumonisins; Glucosyltransferases; Immunohistochemistry; Membrane Potentials; Mitochondria; Oxidative Stress; Paraquat; Photoreceptor Cells, Vertebrate; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Sphingosine | 2006 |
Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation.
Topics: Antigens, Polyomavirus Transforming; Apoptosis; bcl-2-Associated X Protein; Catalytic Domain; Cell Line, Tumor; Enzyme Inhibitors; Humans; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Binding; Protein Conformation; Protein Phosphatase 2; Sphingosine; Structure-Activity Relationship | 2006 |
Apoptosis of human colon carcinoma HT-29 cells induced by ceramide.
Topics: Apoptosis; Cell Line, Tumor; Colonic Neoplasms; DNA Fragmentation; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Humans; Mitochondria; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine | 2006 |
Interleukin-1beta induces hyperpolarization and modulates synaptic inhibition in preoptic and anterior hypothalamic neurons.
Topics: Analysis of Variance; Animals; Bicuculline; Cells, Cultured; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA Antagonists; Hypothalamus; Interleukin-1beta; Membrane Potentials; Mice; Mice, Knockout; Myeloid Differentiation Factor 88; Neural Inhibition; Neurons; Patch-Clamp Techniques; Potassium Channel Blockers; Receptors, Interleukin-1; Sodium Channel Blockers; Sphingosine; Synapses; Tetrodotoxin | 2006 |
C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts.
Topics: Animals; Anisomycin; Cell Differentiation; Cell Line; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Humans; Inflammation; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; JNK Mitogen-Activated Protein Kinases; Kinetics; Mice; Myoblasts; Myogenin; Phosphoproteins; Phosphorylation; Receptor, IGF Type 1; Recombinant Proteins; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Necrosis Factor-alpha; Tyrosine | 2006 |
Thrombospondin-1 C-terminal-derived peptide protects thyroid cells from ceramide-induced apoptosis through the adenylyl cyclase pathway.
Topics: Adenylyl Cyclases; Animals; Apoptosis; Caspase 3; Cells, Cultured; Ceramides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Gene Expression Regulation; Peptides; RNA, Messenger; Sphingosine; Swine; Thrombospondin 1; Thyroid Gland | 2006 |
Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I.
Topics: Animals; Apolipoprotein A-I; Apoptosis; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Biological Transport, Active; Ceramides; CHO Cells; Cholesterol; Cricetinae; Molecular Structure; Signal Transduction; Sphingosine; Stereoisomerism | 2006 |
PACAP and C2-ceramide generate different AP-1 complexes through a MAP-kinase-dependent pathway: involvement of c-Fos in PACAP-induced Bcl-2 expression.
Topics: Animals; Animals, Newborn; Apoptosis; Cell Survival; Cells, Cultured; Cerebellar Cortex; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation; MAP Kinase Signaling System; Neurons; Phosphoprotein Phosphatases; Phosphorylation; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Phosphatase 2; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; Sphingosine; Transcription Factor AP-1; Transcriptional Activation | 2006 |
L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells.
Topics: Animals; Apoptosis; Cell Line; Cell Line, Tumor; CHO Cells; Cisplatin; Cricetinae; Cricetulus; Female; Humans; Neural Cell Adhesion Molecule L1; Ovarian Neoplasms; Sphingosine; Staurosporine; Transfection | 2007 |
Ceramide induces apoptosis via a peroxisome proliferator-activated receptor gamma-dependent pathway.
Topics: Anilides; Apoptosis; Caspases; Colonic Neoplasms; HT29 Cells; Humans; PPAR gamma; Sphingosine | 2006 |
[Effect of ceramide on apoptosis of human colon cancer HT-29 cells].
Topics: Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Down-Regulation; Enzyme Inhibitors; Gene Expression; Humans; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; Sphingosine; Up-Regulation | 2006 |
Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent.
Topics: Animals; Apoptosis; Biomarkers; Blotting, Western; Bone Development; Cell Differentiation; Cell Line; Cells, Cultured; Chondrocytes; Collagen Type II; Collagen Type X; Cytokines; Dose-Response Relationship, Drug; Growth Plate; High Mobility Group Proteins; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Metatarsal Bones; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinase 3; Oncogene Protein v-akt; Organ Culture Techniques; Phosphoproteins; Phosphorylation; SOX9 Transcription Factor; Sphingosine; Transcription Factors; Tyrphostins | 2006 |
Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells.
Topics: Actins; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Glucose Oxidase; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Muscle Fibers, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Transport; Proto-Oncogene Proteins c-akt; rac GTP-Binding Proteins; Receptor, Insulin; Sphingosine | 2007 |
Ceramide induces apoptosis in human lung adenocarcinoma A549 cells through mitogen-activated protein kinases.
Topics: Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Humans; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Sphingosine | 2007 |
On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase.
Topics: Animals; Ceramides; CHO Cells; Cricetinae; Cricetulus; Mice; Phospholipid Ethers; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Platelet Activating Factor; Sphingosine | 2007 |
Impaired Fas-induced apoptosis of T lymphocytes in patients with abdominal aortic aneurysms.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Aortic Aneurysm, Abdominal; Apoptosis; Atherosclerosis; Autoimmunity; Down-Regulation; fas Receptor; Female; Glucocorticoids; Humans; Male; Methylprednisolone; Middle Aged; Sphingosine; T-Lymphocytes | 2007 |
Mechanisms involved in ceramide-induced cell cycle arrest in human hepatocarcinoma cells.
Topics: Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Humans; Liver Neoplasms; PPAR gamma; Signal Transduction; Sphingosine | 2007 |
Membrane microdomain formation is crucial in epiboly during gastrulation of medaka.
Topics: Animals; beta-Cyclodextrins; Blastoderm; Cell Adhesion; Cell Membrane; Cholesterol; Detergents; Gastrula; Lewis X Antigen; Lipids; Membrane Microdomains; Oryzias; Sphingosine; Temperature | 2007 |
Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells.
Topics: Animals; Apoptosis; Brain; Cell Differentiation; Cell Line, Tumor; Dopamine; Dose-Response Relationship, Drug; Down-Regulation; Energy Metabolism; Glycolysis; Insulin-Like Growth Factor I; Membrane Potential, Mitochondrial; Mesencephalon; Mice; Nerve Degeneration; Neurons; Parkinson Disease; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Sphingosine | 2007 |
Inhibition of caspases but not of calpains temporarily protect against C2-ceramide-induced death of CAD cells.
Topics: Analysis of Variance; Animals; Calpain; Caspases; Cell Death; Cell Line; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Mice; Neurons; Neuroprotective Agents; Sphingosine; Tetrazolium Salts; Thiazoles; Time Factors | 2007 |
The acylation of lipophilic alcohols by lysosomal phospholipase A2.
Topics: Acyltransferases; Alcohols; Animals; Cell Line; Dogs; Endosomes; Ethanol; Lysosomes; Models, Biological; Models, Chemical; Monoglycerides; Phosphatidylcholines; Phospholipases A2; Sphingosine; Time Factors | 2007 |
Ceramide-induced cell death in lens epithelial cells.
Topics: Animals; Apoptosis; Caspases; Cattle; Cell Survival; Cells, Cultured; Ceramides; Dose-Response Relationship, Drug; Enzyme Activation; Epithelial Cells; Humans; Lens, Crystalline; Oxidative Stress; Reactive Oxygen Species; Sphingosine; Time Factors | 2007 |
Ceramide inhibits development and cytokinesis and induces apoptosis in preimplantation bovine embryos.
Topics: Animals; Apoptosis; Blastocyst; Caspase 8; Caspase 9; Cattle; Cytokinesis; Embryonic Development; Female; Heat-Shock Response; In Vitro Techniques; Pregnancy; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine | 2008 |
[Association between murine double minute 2 expression and AngII and ceramide induced endothelial cells apoptosis].
Topics: Angiotensin II; Apoptosis; Cells, Cultured; Endothelial Cells; Gene Expression; Humans; Imidazoles; Proto-Oncogene Proteins c-mdm2; Pyridines; RNA, Messenger; Sphingosine; Umbilical Veins | 2007 |
C2-ceramide mediates cerebellar granule cells apoptosis by activation of caspases-2, -9, and -3.
Topics: Animals; Apoptosis; Caspase 2; Caspase 3; Caspase 9; Caspase Inhibitors; Cell Survival; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Rats; Sphingosine | 2008 |
Bax siRNA promotes survival of cultured and allografted granule cell precursors through blockade of caspase-3 cleavage.
Topics: Animals; bcl-2-Associated X Protein; Caspase 3; Caspase Inhibitors; Cell Survival; Cells, Cultured; Cerebellum; Neurons; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Rats, Wistar; RNA Interference; RNA, Small Interfering; Sphingosine; Stem Cell Transplantation; Stem Cells; Transplantation, Homologous | 2008 |
Investigation on C2-ceramide complexes with transition metal ions using electrospray ionization tandem mass spectrometry.
Topics: Cell Membrane; Cobalt; Iron; Manganese; Metals; Nickel; Signal Transduction; Spectrometry, Mass, Electrospray Ionization; Sphingosine | 2008 |
A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides.
Topics: Animals; Benzothiazoles; Bridged-Ring Compounds; Cell Death; Cell Line; Ceramides; Chlorocebus aethiops; COS Cells; Humans; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Sphingosine; Transfection | 2009 |
Activation of telomerase and cyclooxygenase-2 in PDGF and FGF inhibition of C2-ceramide-induced apoptosis.
Topics: Animals; Apoptosis; Cell Survival; Ceramides; Cyclooxygenase 2; Cytoprotection; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 2; JNK Mitogen-Activated Protein Kinases; Lysophospholipids; Mice; NIH 3T3 Cells; Phosphorylation; Platelet-Derived Growth Factor; Sphingosine; Telomerase | 2009 |
Nerve growth factor, sphingomyelins, and sensitization in sensory neurons.
Topics: Action Potentials; Animals; Cells, Cultured; Ceramides; Lysophospholipids; Nerve Growth Factor; Patch-Clamp Techniques; Phosphotransferases (Alcohol Group Acceptor); Sensory Receptor Cells; Signal Transduction; Sphingomyelins; Sphingosine | 2008 |
BM88/Cend1 regulates stimuli-induced intracellular calcium mobilization.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Apoptosis; Calcium; Calcium Signaling; Cell Differentiation; Cell Proliferation; Intracellular Fluid; Membrane Proteins; Mice; Molecular Sequence Data; Nerve Tissue Proteins; Neurogenesis; Neurons; Receptors, Purinergic P2; Sequence Alignment; Sphingosine; Transfection; Tumor Cells, Cultured | 2009 |
[Mitochondrial changes in apoptosis of HT-29 cells induced by C2-ceramide].
Topics: Apoptosis; Enzyme Inhibitors; HT29 Cells; Humans; Membrane Potential, Mitochondrial; Mitochondria; Sphingosine | 2008 |
Lipid droplet biogenesis induced by stress involves triacylglycerol synthesis that depends on group VIA phospholipase A2.
Topics: Animals; Anti-Bacterial Agents; Calcium; CHO Cells; Cricetinae; Cricetulus; Enzyme Inhibitors; Fatty Acid Synthases; Fatty Acids; Flow Cytometry; Fluorescence; Glucose; Group VI Phospholipases A2; Lipid Metabolism; Oxidative Stress; Phosphorylation; RNA, Small Interfering; Sphingosine; Triglycerides; Tunicamycin; Type C Phospholipases | 2009 |
Retinal flavoprotein autofluorescence as a measure of retinal health.
Topics: Acetylcysteine; Adult; Aged; Antioxidants; Apoptosis; Cells, Cultured; Ceramides; Flavin-Adenine Dinucleotide; Fluorescence; Humans; Hydrogen Peroxide; Middle Aged; Mitochondria; Photography; Retina; Retinal Diseases; Retinal Pigment Epithelium; Sphingosine | 2008 |
Docosahexaenoic acid down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the sphingomyelinase/ceramide pathway.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cells, Cultured; Ceramides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytochrome P-450 CYP2B1; Docosahexaenoic Acids; Down-Regulation; Hepatocytes; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Time Factors; Transcriptional Activation | 2010 |
Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons.
Topics: Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Humans; Indazoles; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Pyrazoles; Sphingosine; Structure-Activity Relationship | 2009 |
Potential mechanisms involved in ceramide-induced apoptosis in human colon cancer HT29 cells.
Topics: Apoptosis; Caspases; Flow Cytometry; HT29 Cells; Humans; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Sphingosine | 2009 |
Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
Topics: Animals; Cell Line; Gene Expression Regulation, Enzymologic; Glucaric Acid; Humans; Insulin; Insulin-Secreting Cells; Islets of Langerhans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Palmitates; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Rats; RNA Precursors; RNA, Messenger; Sphingosine | 2009 |
Alpha A-crystallin and alpha B-crystallin, newly identified interaction proteins of protease-activated receptor-2, rescue astrocytes from C2-ceramide- and staurosporine-induced cell death.
Topics: alpha-Crystallin A Chain; alpha-Crystallin B Chain; Animals; Astrocytes; Cell Death; Cell Line; Cells, Cultured; Humans; Immunoprecipitation; Insecta; Protein Binding; Rats; Receptor, PAR-2; Sphingosine; Staurosporine | 2009 |
Cell-permeable ceramides act as novel regulators of U937 cell-cell adhesion mediated by CD29, CD98, and CD147.
Topics: Basigin; Cell Adhesion; Ceramides; Down-Regulation; Fibronectins; Fusion Regulatory Protein-1; Humans; Integrin alpha4; Integrin beta1; Phosphorylation; Sphingosine; U937 Cells | 2010 |
Apoptotic inducers activate the release of D-aspartate through a hypotonic stimulus-triggered mechanism in PC12 cells.
Topics: Animals; Apoptosis; Aspartic Acid; Calcimycin; Hydrogen Peroxide; Hypotonic Solutions; Ion Channels; Ionophores; Nitrobenzoates; PC12 Cells; Rats; Sphingosine; Staurosporine; Stereoisomerism; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Uric Acid | 2009 |
Synthesis of sphingosine is essential for oxidative stress-induced apoptosis of photoreceptors.
Topics: Animals; Apoptosis; Cells, Cultured; Cytochromes c; Docosahexaenoic Acids; Enzyme Inhibitors; In Situ Nick-End Labeling; Lysophospholipids; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Oxidants; Oxidative Stress; Palmitic Acid; Paraquat; Phosphotransferases (Alcohol Group Acceptor); Photoreceptor Cells, Vertebrate; Rats; Rats, Wistar; Reactive Oxygen Species; Sphingosine | 2010 |
Chemotherapy induces ATP release from tumor cells.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; Cadmium; Cell Line, Tumor; Cisplatin; Etoposide; Flow Cytometry; Fluorescent Antibody Technique; Mice; Mitomycin; Mitoxantrone; Neoplasms; Organoplatinum Compounds; Oxaliplatin; Sphingosine; Thapsigargin | 2009 |
Functional modulation of mitochondria by eicosapentaenoic acid provides protection against ceramide toxicity to C6 glioma cells.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Caspase 3; Cell Line, Tumor; Cell Survival; Ceramides; Eicosapentaenoic Acid; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Proteins; Neurons; Neuroprotective Agents; Rats; Sphingosine; Transcription Factors | 2009 |
Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C2-ceramide and CD95/APO-1/FAS receptor stimulation.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Calcium; Caspase Inhibitors; Chelating Agents; Cysteine Proteinase Inhibitors; Egtazic Acid; Endoplasmic Reticulum; fas Receptor; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Mitochondria; Sphingosine | 2010 |
Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes.
Topics: Animals; Antioxidants; Azoles; Cells, Cultured; Chloride Channels; Chlorides; Cyclopentanes; Estrogen Antagonists; Heart Ventricles; Indans; Isoindoles; Membrane Potentials; Myocytes, Cardiac; Organoselenium Compounds; Osmotic Pressure; Patch-Clamp Techniques; Rabbits; Reactive Oxygen Species; Sphingomyelin Phosphodiesterase; Sphingosine; Tamoxifen | 2010 |
miR-181a and miR-630 regulate cisplatin-induced cancer cell death.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cadmium Chloride; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Cycle; Cell Line, Tumor; Cisplatin; DNA Damage; HeLa Cells; Humans; Lung Neoplasms; MicroRNAs; Oligonucleotide Array Sequence Analysis; Phosphorylation; Sphingosine; Tumor Suppressor Protein p53; Up-Regulation | 2010 |
Optimal suppression of protein phosphatase 2A activity is critical for maintenance of human embryonic stem cell self-renewal.
Topics: Biomarkers; Cell Differentiation; Cell Division; Cell Line; Culture Media, Conditioned; Down-Regulation; Embryonic Stem Cells; Enzyme Activation; Enzyme Inhibitors; Humans; Okadaic Acid; Pluripotent Stem Cells; Protein Phosphatase 2; Signal Transduction; Sphingosine | 2010 |
C2-ceramide inhibits the prostaglandin E2-induced accumulation of cAMP in human gingival fibroblasts.
Topics: Arthritis, Rheumatoid; Cell Differentiation; Ceramides; Colforsin; Dinoprostone; Fibroblasts; Gingiva; Humans; Methyl Ethers; Prostaglandins E; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; RNA, Messenger; Signal Transduction; Sphingomyelins; Sphingosine | 2010 |
Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis.
Topics: 14-3-3 Proteins; Apoptosis; Blotting, Western; Caspase 8; Cell Line, Tumor; Enzyme Inhibitors; Gene Expression Regulation; Gene Knockdown Techniques; Green Fluorescent Proteins; HeLa Cells; Humans; Mitochondria; Protein Binding; Proteomics; Reproducibility of Results; RNA, Small Interfering; Sphingosine | 2010 |
Additive effects of C(2)-ceramide on paclitaxel-induced premature senescence of human lung cancer cells.
Topics: Apoptosis; Baculoviral IAP Repeat-Containing 3 Protein; beta-Galactosidase; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; DNA Fragmentation; Extracellular Signal-Regulated MAP Kinases; G2 Phase; Gene Expression; GTP-Binding Proteins; Humans; Inhibitor of Apoptosis Proteins; JNK Mitogen-Activated Protein Kinases; Microfilament Proteins; Muscle Proteins; Osteonectin; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphorylation; Plasminogen Activator Inhibitor 1; Protein Glutamine gamma Glutamyltransferase 2; Proto-Oncogene Proteins c-bcl-2; Sphingosine; Transglutaminases; Ubiquitin-Protein Ligases | 2010 |
Induction of apoptosis by sphingosine, sphinganine, and C(2)-ceramide in human colon cancer cells, but not by C(2)-dihydroceramide.
Topics: Apoptosis; Cell Cycle; Cell Division; Ceramides; Colonic Neoplasms; G2 Phase; HCT116 Cells; HT29 Cells; Humans; Sphingosine | 2010 |
Differential regulation of AKT, MAPK and GSK3β during C2-ceramide-induced neuronal death.
Topics: Animals; Cell Death; Cell Survival; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Insulin-Like Growth Factor I; Mice; Mitogen-Activated Protein Kinases; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Sphingosine | 2010 |
Regulation of autophagic activity by 14-3-3ζ proteins associated with class III phosphatidylinositol-3-kinase.
Topics: 14-3-3 Proteins; Autophagy; Cell Extracts; Cell Line, Tumor; Chromatography, Affinity; Class III Phosphatidylinositol 3-Kinases; Down-Regulation; Enzyme Activation; HEK293 Cells; Humans; Phorbol Esters; Phosphorylation; Protein Binding; RNA, Small Interfering; Signal Transduction; Sphingosine | 2011 |
Regulation of Sertoli cell activin A and inhibin B by tumour necrosis factor α and interleukin 1α: interaction with follicle-stimulating hormone/adenosine 3',5'-cyclic phosphate signalling.
Topics: Animals; Bucladesine; Cells, Cultured; Cyclic AMP; Down-Regulation; Follicle Stimulating Hormone; Inhibin-beta Subunits; Inhibins; Interleukin-1alpha; Male; Phosphodiesterase Inhibitors; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, FSH; Recombinant Proteins; Sertoli Cells; Signal Transduction; Sphingosine; Stem Cell Factor; Transcription, Genetic; Tumor Necrosis Factor-alpha; Up-Regulation | 2011 |
Friendly, and not so friendly, roles of Rac1 in islet β-cell function: lessons learnt from pharmacological and molecular biological approaches.
Topics: Animals; Apoptosis; Cell Line; Cytokines; Glucose; Guanine Nucleotide Exchange Factors; Insulin; Insulin Secretion; Insulin-Secreting Cells; Membrane Potential, Mitochondrial; NADPH Oxidases; Neoplasm Proteins; Oxidative Stress; Palmitates; rac1 GTP-Binding Protein; Rats; Reactive Oxygen Species; RNA, Small Interfering; Sphingosine; T-Lymphoma Invasion and Metastasis-inducing Protein 1; Transfection | 2011 |
Role of JNK/ATF-2 pathway in inhibition of thrombospondin-1 (TSP-1) expression and apoptosis mediated by doxorubicin and camptothecin in FTC-133 cells.
Topics: Activating Transcription Factor 2; Anthracenes; Apoptosis; Camptothecin; Caspase 3; Cell Line, Tumor; Cell Survival; Doxorubicin; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; Sphingosine; Thrombospondin 1; Thyroid Neoplasms | 2011 |
Phosphorylation of Ser45 and Ser59 of αB-crystallin and p38/extracellular regulated kinase activity determine αB-crystallin-mediated protection of rat brain astrocytes from C2-ceramide- and staurosporine-induced cell death.
Topics: alpha-Crystallin B Chain; Animals; Astrocytes; Blotting, Western; Cell Death; Cell Survival; Cells, Cultured; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; JNK Mitogen-Activated Protein Kinases; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Receptor, PAR-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Sphingosine; Staurosporine | 2011 |
Involvement of the sphingolipid ceramide in heat-shock-induced apoptosis of bovine oocytes.
Topics: Animals; Apoptosis; Blastocyst; Cattle; Cell Membrane; Ceramides; Cumulus Cells; DNA Fragmentation; Ectogenesis; Enzyme Inhibitors; Female; Fumonisins; Heat-Shock Response; Hot Temperature; Oocytes; Oogenesis; Osmolar Concentration; Oxidoreductases; Phosphatidylserines; Sphingolipids; Sphingosine; Time Factors | 2011 |
Versican G3 domain modulates breast cancer cell apoptosis: a mechanism for breast cancer cell response to chemotherapy and EGFR therapy.
Topics: Animals; Anthracenes; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Survival; Docetaxel; Doxorubicin; Epirubicin; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Green Fluorescent Proteins; Humans; Mice; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sphingosine; Taxoids; Tyrphostins; Versicans | 2011 |
C6-ceramide enhances Interleukin-12-mediated T helper type 1 cell responses through a cyclooxygenase-2-dependent pathway.
Topics: Animals; Cell Differentiation; Cell Membrane Permeability; Cells, Cultured; Ceramides; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Female; Gene Expression; Interferon-gamma; Interleukin-12; Mice; Mice, Inbred C57BL; Nitrobenzenes; Signal Transduction; Sphingosine; Sulfonamides; T-Box Domain Proteins; Th1 Cells | 2012 |
PINK1 overexpression protects against C2-ceramide-induced CAD cell death through the PI3K/AKT pathway.
Topics: Cell Death; Cell Line; Cell Survival; Humans; Mitochondrial Membranes; Parkinson Disease; Phosphatidylinositol 3-Kinases; Protein Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Sphingosine | 2012 |
Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis.
Topics: Animals; Apoptosis; Cerebral Cortex; Dose-Response Relationship, Drug; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; Pentacyclic Triterpenes; Primary Cell Culture; Rats; Reactive Oxygen Species; Signal Transduction; Sphingosine | 2012 |
Specific phosphorylation of αA-crystallin is required for the αA-crystallin-induced protection of astrocytes against staurosporine and C2-ceramide toxicity.
Topics: alpha-Crystallin A Chain; Animals; Astrocytes; Cell Survival; Phosphorylation; Primary Cell Culture; Rats; Rats, Wistar; Sphingosine; Staurosporine | 2012 |
Regulation of interleukin-1alpha and tumor necrosis factor-alpha-induced interleukin-8 production by amnion-derived (WISH) cells.
Topics: Amnion; Butadienes; Cell Line; Enzyme Inhibitors; Fumonisins; Humans; Imidazoles; Interleukin 1 Receptor Antagonist Protein; Interleukin-1alpha; Interleukin-8; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Pyridines; Sphingosine; Tumor Necrosis Factor-alpha | 2012 |
Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Etoposide; Gene Expression Regulation; Green Fluorescent Proteins; HSP70 Heat-Shock Proteins; Humans; Immunoprecipitation; Neural Inhibition; Neuroblastoma; Neurons; Peptide Fragments; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Binding; Rats; Signal Transduction; Sphingosine; Staurosporine; Transfection | 2012 |
[Effect of ceramide on GSTA1 in Caco-2 cells].
Topics: Caco-2 Cells; Enzyme Activation; Glutathione Transferase; Humans; RNA, Messenger; Sphingosine; Transcriptional Activation; Up-Regulation | 2012 |
Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia.
Topics: Alternative Splicing; Analysis of Variance; Animals; Animals, Newborn; Apoptosis; bcl-X Protein; Brain Injuries; CELF1 Protein; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Female; Functional Laterality; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Hypoxia-Ischemia, Brain; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Male; Mice; Neurons; Pregnancy; Rats; RNA Precursors; RNA-Binding Proteins; RNA, Small Interfering; Sphingosine; Staurosporine; Time Factors; Transfection | 2012 |
Regulation of autophagy and its associated cell death by "sphingolipid rheostat": reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway.
Topics: Animals; Autophagy; Ceramides; CHO Cells; Cricetinae; Cricetulus; Gene Knockdown Techniques; HL-60 Cells; Humans; Lysophospholipids; Phosphoprotein Phosphatases; Phosphorylation; Receptors, Lysosphingolipid; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; TOR Serine-Threonine Kinases | 2012 |
Platelet protease-activated receptor (PAR)4, but not PAR1, associated with neutral sphingomyelinase responsible for thrombin-stimulated ceramide-NF-κB signaling in human platelets.
Topics: Blood Platelets; Ceramides; Humans; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Platelet Activation; Platelet Aggregation; Protein Binding; Receptors, Thrombin; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Tandem Mass Spectrometry; Thrombin | 2013 |
Palmitate induces RIP1-dependent necrosis in RAW 264.7 cells.
Topics: Animals; Antioxidants; Apoptosis; Cell Line; Cell Shape; Cell Survival; Cyclic N-Oxides; Dose-Response Relationship, Drug; GTPase-Activating Proteins; Imidazoles; Indoles; Macrophages; Metalloporphyrins; Mice; Microscopy, Electron, Transmission; Necrosis; Oxidative Stress; Palmitic Acid; Protein Kinase Inhibitors; Reactive Oxygen Species; RNA Interference; Sphingosine; Spin Labels; Transfection | 2012 |
Neurotrophins regulate cholinergic synaptic transmission in cultured rat sympathetic neurons through a p75-dependent mechanism.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cholinergic Neurons; Coculture Techniques; Excitatory Postsynaptic Potentials; Fumonisins; Myocytes, Cardiac; Nerve Growth Factor; Rats; Receptor, Nerve Growth Factor; Sphingosine; Superior Cervical Ganglion | 2013 |
Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction.
Topics: Animal Feed; Animals; Apolipoprotein B-100; Cricetinae; Dietary Fats; Disease Models, Animal; Dyslipidemias; Fatty Acids, Monounsaturated; Fructose; Glucose Intolerance; Hepatitis; Immunosuppressive Agents; Insulin Resistance; Lipoproteins, VLDL; Liver; Male; Mesocricetus; Signal Transduction; Sphingolipids; Sphingosine | 2013 |
Role of mitochondrial Bax, caspases, and MAPKs for ceramide-induced apoptosis in renal proximal tubular cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Caspase Inhibitors; Caspases; Cell Line; Enzyme Activation; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Kidney Tubules, Proximal; Mitochondria; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Sphingosine | 2013 |
Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance.
Topics: Animals; Cell Line; Cell Membrane; Cell Polarity; Enzyme Activation; Glucose Transporter Type 4; Guanine Nucleotide Exchange Factors; Humans; Insulin; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Neoplasm Proteins; Phosphatidylinositols; Phosphorylation; Protein Multimerization; Protein Processing, Post-Translational; Protein Transport; Proto-Oncogene Proteins c-akt; rac1 GTP-Binding Protein; Rats; Signal Transduction; Sphingosine; T-Lymphoma Invasion and Metastasis-inducing Protein 1 | 2013 |
Homocysteine induces cerebral endothelial cell death by activating the acid sphingomyelinase ceramide pathway.
Topics: Amitriptyline; Animals; Cell Death; Cell Survival; Cerebral Cortex; Dose-Response Relationship, Drug; Endothelial Cells; Homocysteine; Mice; Primary Cell Culture; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Time Factors | 2013 |
Correlation between potassium channel expression and sensitivity to drug-induced cell death in tumor cell lines.
Topics: Antineoplastic Agents; Apoptosis; Cell Death; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Cisplatin; Gene Expression Regulation, Neoplastic; Humans; Kv1.1 Potassium Channel; Kv1.3 Potassium Channel; Mitochondria; Neoplasms; Potassium Channel Blockers; RNA, Messenger; Sphingosine; Staurosporine; Tumor Burden | 2014 |
Sphingosine-1-phosphate inhibits ceramide-induced apoptosis during murine preimplantation embryonic development.
Topics: Animals; Apoptosis; Blastocyst; Caspases; Embryo Culture Techniques; Embryonic Development; Female; Gene Expression Regulation, Developmental; Lysophospholipids; Mice; Pregnancy; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Tumor Suppressor Protein p53 | 2013 |
C2-phytoceramide perturbs lipid rafts and cell integrity in Saccharomyces cerevisiae in a sterol-dependent manner.
Topics: Cell Death; Cell Survival; Cell Wall; Ergosterol; G2 Phase Cell Cycle Checkpoints; Gene Expression; Humans; Membrane Microdomains; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Signal Transduction; Sphingosine | 2013 |
Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway.
Topics: Aged; Antibodies, Monoclonal; Apoptosis; Arginine; Case-Control Studies; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Culture Media, Serum-Free; Doxorubicin; Enzyme Activation; fas Receptor; Female; Fibroblasts; Humans; JNK Mitogen-Activated Protein Kinases; Male; Middle Aged; Signal Transduction; Sphingosine | 2013 |
Protein tyrosine phosphatase 1B inhibition ameliorates palmitate-induced mitochondrial dysfunction and apoptosis in skeletal muscle cells.
Topics: Active Transport, Cell Nucleus; Adenosine Triphosphate; Apoptosis; Caspase 3; Caspase 9; Cell Line; Cell Survival; DNA-Binding Proteins; Forkhead Box Protein O1; Forkhead Transcription Factors; Humans; Insulin; JNK Mitogen-Activated Protein Kinases; Mitochondria; Mitochondrial Proteins; Muscle Fibers, Skeletal; Muscle, Skeletal; Nuclear Respiratory Factor 1; Palmitates; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Sirtuin 1; Sphingosine; Transcription Factor RelA; Transcription Factors | 2013 |
Liposomal codelivery of a synergistic combination of bioactive lipids in the treatment of acute myeloid leukemia.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Ceramides; Cholesterol; Chromatography, Liquid; Drug Delivery Systems; Female; Humans; Inhibitory Concentration 50; Leukemia, Myeloid, Acute; Lipids; Liposomes; Mice; Mice, Inbred BALB C; Mice, SCID; Phosphatidylcholines; Sphingosine; Tandem Mass Spectrometry; U937 Cells; Xenograft Model Antitumor Assays | 2014 |
Hypermethylation contributes to down-regulation of lysosomal β-hexosaminidase α subunit in prostate cancer cells.
Topics: beta-Hexosaminidase alpha Chain; Cell Line, Tumor; DNA Methylation; Down-Regulation; Enzyme Repression; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Male; Promoter Regions, Genetic; Prostatic Neoplasms; Sphingosine | 2014 |
C2-ceramide induces cell death and protective autophagy in head and neck squamous cell carcinoma cells.
Topics: Apoptosis; Autophagy; Carcinoma, Squamous Cell; Caspase 3; Cell Line, Tumor; DNA Fragmentation; Head and Neck Neoplasms; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Necrosis; Phosphorylation; Signal Transduction; Sphingosine; TOR Serine-Threonine Kinases | 2014 |
Ceramide inhibits insulin-stimulated Akt phosphorylation through activation of Rheb/mTORC1/S6K signaling in skeletal muscle.
Topics: Animals; Cell Line; Enzyme Activation; Glucose; HEK293 Cells; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Luciferases; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Monomeric GTP-Binding Proteins; Multiprotein Complexes; Muscle Fibers, Skeletal; Neuropeptides; Phosphorylation; Protein Kinase C-delta; Proto-Oncogene Proteins c-akt; Ras Homolog Enriched in Brain Protein; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; RNA Interference; RNA, Small Interfering; Signal Transduction; Sirolimus; Sphingosine; TOR Serine-Threonine Kinases | 2014 |
Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells.
Topics: Animals; Apoptosis; Cell Line, Tumor; Dopaminergic Neurons; Down-Regulation; Gene Knockdown Techniques; Humans; Mice; Mitochondria; Mitochondrial Proteins; Protein Kinases; Rotenone; Sphingosine | 2014 |
Ceramide changes the mediator of flow-induced vasodilation from nitric oxide to hydrogen peroxide in the human microcirculation.
Topics: Adipose Tissue; Adult; Aged; Antioxidants; Arterioles; Case-Control Studies; Coronary Artery Disease; Coronary Circulation; Coronary Vessels; Enzyme Inhibitors; Female; Humans; Hydrogen Peroxide; Male; Microcirculation; Microscopy, Video; Middle Aged; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Regional Blood Flow; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingosine; Time Factors; Vasodilation | 2014 |
Ceramide signaling in the coronary microcirculation: a double-edged sword?
Topics: Adipose Tissue; Coronary Artery Disease; Coronary Circulation; Coronary Vessels; Female; Humans; Hydrogen Peroxide; Male; Microcirculation; Nitric Oxide; Sphingosine; Vasodilation | 2014 |
Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells.
Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Caveolin 1; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Free Radical Scavengers; Hydrogen Peroxide; Insulin-Secreting Cells; Male; Membrane Potential, Mitochondrial; Mice, Inbred C57BL; Microscopy, Confocal; Oxidants; Palmitates; Phosphorylation; Pyrimidines; Reactive Oxygen Species; Sphingosine; src-Family Kinases; Tyrosine | 2015 |
Differential apoptotic effect and metabolism of N-acetylsphingosine and N-hexanoylsphingosine in CHP-100 human neurotumor cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Ceramides; Humans; Neoplasms, Neuroepithelial; Neuroepithelial Cells; Sphingosine | 2015 |
Extracellular α-crystallin protects astrocytes from cell death through activation of MAPK, PI3K/Akt signaling pathway and blockade of ROS release from mitochondria.
Topics: alpha-Crystallins; Animals; Antimycin A; Astrocytes; Brain; Cell Death; Cell Survival; Cells, Cultured; Escherichia coli; Extracellular Space; MAP Kinase Signaling System; Mitochondria; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Sphingosine; Staurosporine; TOR Serine-Threonine Kinases | 2015 |
Analysis of lipid-composition changes in plasma membrane microdomains.
Topics: Animals; Cell Line; Gene Knockout Techniques; Lipid Metabolism; Lipids; Membrane Microdomains; Mice; Silicon Dioxide; Sphingosine; Transferases (Other Substituted Phosphate Groups) | 2015 |
Overexpression of DJ-1 protects against C2-ceramide-induced neuronal death through activation of the PI3K/AKT pathway and inhibition of autophagy.
Topics: Animals; Autophagy; Cell Line; Cell Survival; Mice; Neurons; Oncogene Proteins; Peroxiredoxins; Phosphatidylinositol 3-Kinases; Protein Deglycase DJ-1; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Sphingosine; TOR Serine-Threonine Kinases | 2015 |
[Ceramide participates in cell programmed death induced by Type II anti-CD20 mAb].
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Cell Line, Tumor; Humans; Lymphoma, Non-Hodgkin; Rituximab; Sphingosine | 2015 |
Direct regulation of IGF-binding protein 1 promoter by interleukin-1β via an insulin- and FoxO-1-independent mechanism.
Topics: Animals; Blotting, Western; Extracellular Signal-Regulated MAP Kinases; Forkhead Box Protein O1; Gene Expression Regulation; Glucose; Hep G2 Cells; Hepatocytes; Humans; Insulin; Insulin-Like Growth Factor Binding Protein 1; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred F344; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sphingomyelin Phosphodiesterase; Sphingosine | 2016 |
Acid sphingomyelinase mediates 50-Hz magnetic field-induced EGF receptor clustering on lipid raft.
Topics: Amnion; Epithelial Cells; ErbB Receptors; Humans; Imipramine; Magnetic Fields; Membrane Microdomains; Phosphorylation; Sphingomyelin Phosphodiesterase; Sphingosine | 2016 |
C2-ceramide enhances sorafenib-induced caspase-dependent apoptosis via PI3K/AKT/mTOR and Erk signaling pathways in HCC cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Flow Cytometry; Humans; Niacinamide; Phenylurea Compounds; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Sorafenib; Sphingosine; TOR Serine-Threonine Kinases | 2017 |
The TrkA receptor mediates experimental thermal hyperalgesia produced by nerve growth factor: Modulation by the p75 neurotrophin receptor.
Topics: Analgesics; Aniline Compounds; Animals; Antibodies; Benzylidene Compounds; Carbazoles; Disease Models, Animal; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Indole Alkaloids; Male; Nerve Growth Factor; Nerve Tissue Proteins; Protein Kinase C; Rats, Sprague-Dawley; Receptor, trkA; Receptors, Growth Factor; Receptors, Nerve Growth Factor; Sphingosine; Touch; TRPV Cation Channels | 2017 |
Preferential hydrolysis of truncated oxidized glycerophospholipids by lysosomal phospholipase A2.
Topics: Acylation; Amiodarone; Animals; CHO Cells; Cricetulus; Fatty Acids; Glycerophospholipids; Hydrogen-Ion Concentration; Hydrolysis; Liposomes; Lysosomes; Oxidation-Reduction; Phosphatidylcholines; Phospholipases A2; Sphingosine | 2017 |
C2-ceramide influences alveolar epithelial barrier function by downregulating Zo-1, occludin and claudin-4 expression.
Topics: Alveolar Epithelial Cells; Animals; Apoptosis; Cell Survival; Claudin-4; Dose-Response Relationship, Drug; Down-Regulation; Mice; Mice, Inbred ICR; Occludin; Permeability; Primary Cell Culture; Pulmonary Edema; Sphingosine; Zonula Occludens-1 Protein | 2017 |
Autophagy inhibits C2-ceramide-mediated cell death by decreasing the reactive oxygen species levels in SH-SY5Y cells.
Topics: Autophagy; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Sphingosine | 2017 |
Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Gene Expression Regulation; Mice; Phosphoproteins; Phosphorylation; Piperazines; Protein Phosphatase 2; Proteomics; Signal Transduction; Sphingolipids; Sphingosine | 2019 |
Evaluation of chemotherapeutic and cancer-protective properties of sphingosine and C2-ceramide in a human breast stem cell derived carcinogenesis model.
Topics: Breast; Breast Neoplasms; Carcinogenesis; Cell Differentiation; Cell Transformation, Neoplastic; Epithelial Cells; Female; Humans; MCF-7 Cells; Neoplastic Stem Cells; Sphingosine; Stem Cells | 2019 |
Acetaminophen-induced hepatocyte injury: C2-ceramide and oltipraz intervention, hepatocyte nuclear factor 1 and glutathione S-transferase A1 changes.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Cell Culture Techniques; Cell Proliferation; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Gene Expression; Glutathione Transferase; Hep G2 Cells; Hepatocyte Nuclear Factor 1; Hepatocytes; Humans; Pyrazines; Sphingosine; Thiones; Thiophenes | 2019 |
Ceramide: a novel inducer for neural tube defects.
Topics: Animals; Cell Line; Ceramides; Chick Embryo; Glutathione; Mice; Neural Tube Defects; Neurulation; Oxidation-Reduction; Oxidative Stress; PAX3 Transcription Factor; Reactive Oxygen Species; Sphingosine | 2019 |
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease.
Topics: Acetyl Coenzyme A; Acetylation; Alzheimer Disease; Animals; Anti-Inflammatory Agents; Brain; Cell Line; Cyclooxygenase 2; Disease Models, Animal; Humans; Male; Memory; Mice; Mice, Transgenic; Microglia; Mutagenesis; Neurons; Phagocytosis; Phosphotransferases (Alcohol Group Acceptor); Presenilin-1; Primary Cell Culture; Recombinant Proteins; Serine; Sphingosine | 2020 |
Esterification of side-chain oxysterols by lysosomal phospholipase A2.
Topics: Animals; Catalysis; Cholesterol; Esterification; Humans; Hydroxycholesterols; Lysosomes; Macrophages; Mice; Oxysterols; Phosphatidylcholine-Sterol O-Acyltransferase; Phospholipases A2; Sphingosine | 2020 |
Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway.
Topics: Chemical and Drug Induced Liver Injury; Glutathione Transferase; Hep G2 Cells; Hepatocyte Nuclear Factor 1-alpha; Humans; MAP Kinase Signaling System; Pyrazines; Sphingosine; Thiones; Thiophenes | 2021 |