Compounds > n-acetylneuraminic acid

n-acetylneuraminic acid and n-acetylmannosamine

n-acetylneuraminic acid has been researched along with n-acetylmannosamine in 76 studies

Research

Studies (76)

TimeframeStudies, this research(%)All Research%
pre-199017 (22.37)18.7374
1990's12 (15.79)18.2507
2000's19 (25.00)29.6817
2010's24 (31.58)24.3611
2020's4 (5.26)2.80

Authors

AuthorsStudies
Bauer, C; Danneschewski, S; Giannis, A; Henk, E; Henk, T; Reutter, W; Sandhoff, K; Zeitler, R1
Banzer, JP; Bauer, C; Reutter, W; Zeitler, R1
Chen, T; Gesundheit, N; Magner, JA; Weintraub, BD1
Cherian, L; Klemm, WR; Mathew, J1
Diaz, S; Milewski, M; Muchmore, EA; Varki, A1
Durrie, R; Rosenberg, A1
Ashwell, G; Gahl, WA; Seppala, R; Tietze, F; Weiss, P1
Schauer, R; Shaw, L1
Scocca, JR1
Bauer, C; Reutter, W1
Dahlin, CE; Sherblom, AP1
Aula, P; Ehnholm, C; Gahmberg, CG; Kovanen, PT; Raivio, KO; Renlund, M1
Gahl, WA; Renlund, M; Tietze, F1
Miller, CS; Reynolds, LW; Scocca, J; Thomas, GH1
Rosenberg, A; Saito, M1
Dawson, G; Hancock, LW; Horwitz, AL1
Blok, CM; Ferwerda, W; Van Rinsum, J1
Ferrero, MA; Reglero, A; Rodríguez-Aparicio, LB1
Ghosh, P; Lakshman, MR; Liu, QH; Okoh, C1
Beighton, D; Byers, HL; Homer, KA2
Dawson, MJ; Drake, CS; Mahmoudian, M; Middleton, RF; Montgomery, DS; Noble, D; Piercey, JE; Ramlakhan, D; Todd, M1
Bertozzi, CR; Mahal, LK; Yarema, KJ1
Ender, I; Ghosh, P; Hale, EA1
Plumbridge, J; Vimr, E1
Dutina, G; Etcheverry, T; Gunson, J; Ryll, T; Santell, L; Santoris, M; Wang, A; Warner, TG1
Beighton, D; Byers, HL; Homer, KA; Tarelli, E1
Bertozzi, CR; Charters, NW; Jacobs, CL; Mahal, LK; Nauman, DA; Yarema, KJ1
Baker, KN; Freedman, RB; Hills, AE; Hoare, M; James, DC; Rendall, MH1
Berger, M; Hinderlich, S; Keppler, OT; Pawlita, M; Reutter, W1
Bertozzi, CR; Chai, DH; Goon, S; Hang, HC; Hinderlich, S; Jacobs, CL; Yarema, KJ1
Berry, A; Nelson, A; Suryanti, V1
FELSENFELD, H; WARREN, L1
CARROLL, PM; CORNFORTH, JW1
Hong, Y; Stanley, P1
Ringenberg, MA; Steenbergen, SM; Vimr, ER1
Betenbaugh, MJ; Hinderlich, S; Lawrence, S; Lee, YC; Viswanathan, K; Yarema, KJ1
Baskaran, G; Goon, S; Jones, MB; Kim, EJ; Rhee, JK; Sampathkumar, SG; Yarema, KJ1
Jones, MB; Li, AV; Sampathkumar, SG; Sun, Z; Yarema, KJ1
Howarth, M; Ting, AY1
Ikeda, K; Mori, H; Sato, M1
Gagiannis, D; Gossrau, R; Horstkorte, R; Reutter, W; Zimmermann-Kordmann, M1
Hanson, SR; Hsu, TL; Kishikawa, K; Sawa, M; Wang, SK; Wong, CH1
Quaggin, SE1
Ciccone, C; Darvish, D; Gahl, WA; Galeano, B; Hoffmann, VJ; Hoogstraten-Miller, S; Huizing, M; Klootwijk, R; Krasnewich, DM; Manoli, I; Starost, MF; Sun, M; Zerfas, PM1
Ezquerro-Sáenz, C; Ferrero, MA; Lopez-Velasco, FF; Lozano, S; Martínez-Blanco, H; Navasa, N; Rodríguez-Aparicio, LB1
Kamiura, R1
Hrabárová, E; Nahálka, J; Vikartovská, A1
Bai, H; Chen, J; Hu, S; Jiang, W; Luo, J; Shao, L; Yang, Y; Yang, Z1
Horstkorte, R; Klein, A; Klukas, C; Schreiber, F; Simm, A; Weidemann, W1
Malicdan, MC; Nishino, I; Noguchi, S1
Bond, MR; Kim, J; Kohler, JJ; Patrie, SM; Yang, F; Yu, SH; Zhang, H1
Goto, Y; Hayashi, YK; Malicdan, MC; Nishino, I; Noguchi, S; Nonaka, I; Tokutomi, T1
Ciccone, C; Darvish, D; Gahl, WA; Hoogstraten-Miller, S; Huizing, M; Kakani, S; Klootwijk, ED; Kopp, JB; Manoli, I; Niethamer, T; Poling, J; Ten Hagen, KG; Tian, E; Yardeni, T; Zerfas, P1
Fan, H; Hinderlich, S; Martinez, J; Moniot, S; Nguyen, LD; Reutter, W; Saenger, W; Tauberger, E; Zimmer, R1
Chen, L; Liang, JF1
Andrew, P; Bidossi, A; Colomba, L; Docquier, JD; Gerlini, A; Gualdi, L; Hayre, JK; Oggioni, MR; Pozzi, G; Ricci, S; Trappetti, C1
Geisler, C; Jarvis, DL; Khoo, KH; Kuo, CW; Mabashi-Asazuma, H; Shi, X1
Blatchford, PA; Hooks, DO; Rehm, BH1
Alonzi, DS; Blériot, Y; Butters, TD; Dorward, H; Gahl, WA; Huizing, M; Kukushkin, NV; Le Poëc-Celic, E; Leoyklang, P; Patzel, KA; Sollogoub, M; Xu, B; Yardeni, T; Zhang, Y1
Jiao, W; Joseph, DD; Kessans, SA; Parker, EJ1
Cho, A; Hayashi, YK; Malicdan, MC; Mine, T; Nishino, I; Noguchi, S; Nonaka, I; Yamamoto, T; Yonekawa, T1
Giannis, A; Kannicht, C; Kohla, G; Nguyen, LD; Reutter, W; Rigol, S; Solecka, B; Wratil, PR1
Feng, J; Gu, Z; Ji, W; Ouyang, P; Song, T; Sun, W; Xie, J; Zhang, D1
Amara, K; Bang, H; Baum, W; Dietel, K; Frühbeißer, S; Gröhn, F; Harre, U; Herrmann, M; Klareskog, L; Kocijan, R; Koeleman, CA; Krönke, G; Lang, SC; Lux, A; Malmström, V; Nimmerjahn, F; Pfeifle, R; Rombouts, Y; Scherer, HU; Schett, G; Toes, RE1
Carrillo-Carrasco, N; Fang, M; Gahl, WA; Gillespie, B; Huizing, M; Li, Y; McKew, JC; Shi, Y; Wang, AQ; Xu, X; Yang, N; Yorke, S; Zhang, M1
Betenbaugh, MJ; Bhattacharya, R; Chung, CY; Ren, X; Tang, J; Wang, Q; Yarema, KJ; Yin, B1
Carrillo, N; Celeste, F; Ciccone, C; Cradock, J; Gahl, WA; Goldspiel, B; Huizing, M; Latham, LL; Malicdan, MC; McKew, JC; Terse, P; Wang, AQ; Xu, X; Yang, N; Yorke, S1
Babu, M; Emili, A; Goodacre, N; Rodionova, IA; Saier, MH; Uetz, P1
Fujiyama, K; Misaki, R; Ohashi, T; Thi Sam, N1
Austin, M; Clarke, A; Dharmarha, V; Douville, C; Galizzi, M; Gowda, P; Moremen, KW; Nairn, AV; Park, M; Saeui, CT; Shah, SR; Yarema, KJ1
Adema, GJ; Boltje, TJ; Büll, C; Derks, MT; Moons, SJ1
Dold, JEGA; Funke, M; Helfrich, S; Holzer, AK; Karreman, C; Klima, S; Kranaster, P; Krebs, A; Leist, M; Nyffeler, J; Wittmann, V1
Chen, H; Guo, K; Lu, J; Ma, Y; Pan, P; Wu, M1
Agatemor, C; Bhattacharya, R; Du, J; Jia, X; Saeui, CT; Yarema, KJ1
Bayman, L; Berry, SM; Bradley, K; Carrillo, N; Ciccone, C; Class, B; Coffey, CS; Driscoll, C; Gahl, WA; Heiss, JD; Huizing, M; Jodarski, C; Joe, G; Leoyklang, P; Liu, CY; Malicdan, MC; Parks, R; Perreault, J; Quintana, M; Shrader, JA; Slota, C; Van Wart, S1

Reviews

2 review(s) available for n-acetylneuraminic acid and n-acetylmannosamine

ArticleYear
[Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2007, Volume: 52, Issue:13 Suppl

    Topics: Cell Membrane; Chemistry, Organic; Hexosamines; Histocytochemistry; Molecular Probe Techniques; Molecular Probes; N-Acetylneuraminic Acid; Oligosaccharides

2007
[Animal model of distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy and preclinical trial with sugar compounds].
    Brain and nerve = Shinkei kenkyu no shinpo, 2010, Volume: 62, Issue:6

    Topics: Administration, Oral; Animals; Disease Models, Animal; Distal Myopathies; Drug Evaluation, Preclinical; Hexosamines; Humans; Inclusion Bodies; Lactose; Mice; Mice, Transgenic; N-Acetylneuraminic Acid; Sialic Acids; Vacuoles

2010

Trials

2 trial(s) available for n-acetylneuraminic acid and n-acetylmannosamine

ArticleYear
Safety, pharmacokinetics and sialic acid production after oral administration of N-acetylmannosamine (ManNAc) to subjects with GNE myopathy.
    Molecular genetics and metabolism, 2017, Volume: 122, Issue:1-2

    Topics: Administration, Oral; Adult; Aged; Alleles; Animals; Distal Myopathies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Hexosamines; Homozygote; Humans; Male; Middle Aged; Muscles; Mutation; N-Acetylneuraminic Acid; Phosphotransferases (Alcohol Group Acceptor)

2017
Safety and efficacy of N-acetylmannosamine (ManNAc) in patients with GNE myopathy: an open-label phase 2 study.
    Genetics in medicine : official journal of the American College of Medical Genetics, 2021, Volume: 23, Issue:11

    Topics: Adult; Distal Myopathies; Hexosamines; Humans; Muscular Diseases; N-Acetylneuraminic Acid

2021

Other Studies

72 other study(ies) available for n-acetylneuraminic acid and n-acetylmannosamine

ArticleYear
Inhibition of N-acetylglucosamine kinase and N-acetylmannosamine kinase by 3-O-methyl-N-acetyl-D-glucosamine in vitro.
    European journal of biochemistry, 1992, Mar-15, Volume: 204, Issue:3

    Topics: Acetylglucosamine; Animals; Binding, Competitive; Cell Survival; Glycoproteins; Hexosamines; Humans; Liver; N-Acetylneuraminic Acid; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Inbred Strains; Sialic Acids; Tumor Cells, Cultured

1992
Inhibition of the biosynthesis of N-acetylneuraminic acid by metal ions and selenium in vitro.
    Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 1992,Summer, Volume: 5, Issue:2

    Topics: Acetylglucosamine; Animals; Enzyme Inhibitors; Hexosamines; Metals; N-Acetylneuraminic Acid; Protein Precursors; Rats; Rats, Inbred Strains; Selenium; Sialic Acids; Sulfhydryl Compounds; Uridine Diphosphate N-Acetylglucosamine

1992
Differential sulfation and sialylation of secreted mouse thyrotropin (TSH) subunits: regulation by TSH-releasing hormone.
    Endocrinology, 1986, Volume: 119, Issue:2

    Topics: Animals; Glycoprotein Hormones, alpha Subunit; Hexosamines; Hexosaminidases; Hypothyroidism; Macromolecular Substances; Methionine; Mice; N-Acetylneuraminic Acid; Peptide Fragments; Pituitary Gland; Pituitary Hormones, Anterior; Pituitary Neoplasms; Sialic Acids; Sulfates; Thyrotropin; Thyrotropin-Releasing Hormone

1986
Ethanol-induced hydrolysis of brain sialoglycoconjugates in the rat: effect of sialic acid in antagonizing ethanol intoxication.
    Alcoholism, clinical and experimental research, 1989, Volume: 13, Issue:3

    Topics: Alcoholic Intoxication; Animals; Brain; Gangliosides; Glycolipids; Hexosamines; Male; Motor Skills; N-Acetylneuraminic Acid; Neuraminidase; Pentobarbital; Rats; Sialic Acids; Sleep Stages

1989
Biosynthesis of N-glycolyneuraminic acid. The primary site of hydroxylation of N-acetylneuraminic acid is the cytosolic sugar nucleotide pool.
    The Journal of biological chemistry, 1989, Dec-05, Volume: 264, Issue:34

    Topics: Animals; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Cytidine Monophosphate N-Acetylneuraminic Acid; Cytosol; Hexosamines; Hydroxylation; Kinetics; Mice; Mixed Function Oxygenases; N-Acetylneuraminic Acid; Neuraminic Acids; Plasmacytoma; Radioisotope Dilution Technique; Sialic Acids; Tumor Cells, Cultured

1989
Anabolic sialosylation of gangliosides in situ in rat brain cortical slices.
    Journal of lipid research, 1989, Volume: 30, Issue:8

    Topics: Animals; Cell Membrane; Cerebral Cortex; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Culture Techniques; Cytidine Monophosphate N-Acetylneuraminic Acid; Gangliosides; Golgi Apparatus; Hexosamines; Monensin; N-Acetylneuraminic Acid; Rats; Rats, Inbred Strains; Sialic Acids; Sialyltransferases

1989
Identification of the metabolic defect in sialuria.
    The Journal of biological chemistry, 1989, Oct-25, Volume: 264, Issue:30

    Topics: Carbohydrate Epimerases; Carbohydrate Metabolism, Inborn Errors; Carrier Proteins; Cells, Cultured; Feedback; Fibroblasts; Hexosamines; Humans; Kinetics; N-Acetylneuraminic Acid; Reference Values; Sialic Acids; Skin

1989
The biosynthesis of N-glycoloylneuraminic acid occurs by hydroxylation of the CMP-glycoside of N-acetylneuraminic acid.
    Biological chemistry Hoppe-Seyler, 1988, Volume: 369, Issue:6

    Topics: Animals; Carbon Radioisotopes; Cytidine Monophosphate N-Acetylneuraminic Acid; Cytochrome P-450 Enzyme System; Hexosamines; Hydroxylation; Mixed Function Oxygenases; Mucins; N-Acetylneuraminic Acid; Neuraminic Acids; Sialic Acids; Sialyltransferases; Steroid Hydroxylases; Subcellular Fractions; Submandibular Gland; Swine; Tritium

1988
Identification of N-acetylhexosamines produced by enzymes of the N-acetylneuraminic acid metabolic pathway by borate complex anion-exchange chromatography of the corresponding N-acetylhexosaminitols.
    Analytical biochemistry, 1986, Volume: 156, Issue:1

    Topics: Borates; Carbohydrate Epimerases; Carrier Proteins; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Fibroblasts; Hexosamines; Humans; N-Acetylneuraminic Acid; Oxo-Acid-Lyases; Sialic Acids; Skin; Sugar Alcohols

1986
Inhibitors of glycoprotein biosynthesis.
    Advances in enzyme regulation, 1985, Volume: 24

    Topics: Animals; Carbohydrates; Fucose; Galactose; Glucose; Glycoproteins; Hexosamines; In Vitro Techniques; Liver; N-Acetylneuraminic Acid; Rats; Rats, Inbred Strains; Sialic Acids

1985
N-Acetylneuraminic acid and N-glycolylneuraminic acid in the O-linked oligosaccharides of a tumor cell glycoprotein. Incorporation and distribution.
    The Journal of biological chemistry, 1985, Feb-10, Volume: 260, Issue:3

    Topics: Adenocarcinoma; Animals; beta-Galactosidase; Carbohydrate Conformation; Cell Line; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Female; Hexosamines; Mammary Neoplasms, Experimental; Mucin-4; N-Acetylneuraminic Acid; N-Acylneuraminate Cytidylyltransferase; Neuraminic Acids; Oligosaccharides; Rats; Sialic Acids; Sialoglycoproteins

1985
Studies on the defect underlying the lysosomal storage of sialic acid in Salla disease. Lysosomal accumulation of sialic acid formed from N-acetyl-mannosamine or derived from low density lipoprotein in cultured mutant fibroblasts.
    The Journal of clinical investigation, 1986, Volume: 77, Issue:2

    Topics: Cells, Cultured; Fibroblasts; Hexosamines; Humans; Lipoproteins, LDL; Lysosomes; Metabolism, Inborn Errors; N-Acetylneuraminic Acid; Sialic Acids; Tritium

1986
Defective sialic acid egress from isolated fibroblast lysosomes of patients with Salla disease.
    Science (New York, N.Y.), 1986, May-09, Volume: 232, Issue:4751

    Topics: Cell Fractionation; Fibroblasts; Hexosamines; Humans; Lysosomes; Metabolism, Inborn Errors; N-Acetylneuraminic Acid; Sialic Acids; Subcellular Fractions

1986
Accumulation of N-acetylneuraminic acid (sialic acid) in human fibroblasts cultured in the presence of N-acetylmannosamine.
    Biochimica et biophysica acta, 1985, Jul-30, Volume: 846, Issue:1

    Topics: Biological Transport, Active; Biotransformation; Cells, Cultured; Cytidine Monophosphate N-Acetylneuraminic Acid; Fibroblasts; Hexosamines; Humans; N-Acetylneuraminic Acid; Sialic Acids

1985
Identification and characterization of N-acetyl-2,3-didehydro-2-deoxyneuraminic acid as a metabolite in mammalian brain.
    Biochemistry, 1984, Jul-31, Volume: 23, Issue:16

    Topics: Animals; Brain; Brain Chemistry; Cattle; Chromatography, Thin Layer; Gas Chromatography-Mass Spectrometry; Hexosamines; Hydrogenation; N-Acetylneuraminic Acid; Rats; Rats, Inbred Strains; Sialic Acids

1984
N-acetylneuraminic acid and sialoglycoconjugate metabolism in fibroblasts from a patient with generalized N-acetylneuraminic acid storage disease.
    Biochimica et biophysica acta, 1983, Oct-04, Volume: 760, Issue:1

    Topics: Carbohydrate Metabolism, Inborn Errors; Cells, Cultured; Fibroblasts; Gangliosides; Glucosamine; Hexosamines; Humans; N-Acetylneuraminic Acid; Reference Values; Sialic Acids; Sialoglycoproteins; Skin; Tritium

1983
Synthesis of N-acetylneuraminic acid and of CMP-N-acetylneuraminic acid in the rat liver cell.
    The Biochemical journal, 1983, Oct-15, Volume: 216, Issue:1

    Topics: Animals; Cytidine Monophosphate N-Acetylneuraminic Acid; Hexosamines; Liver; Male; N-Acetylneuraminic Acid; Rats; Rats, Inbred Strains; Sialic Acids; Sialoglycoproteins; Time Factors

1983
N-acetyl-D-neuraminic acid synthesis in Escherichia coli K1 occurs through condensation of N-acetyl-D-mannosamine and pyruvate.
    The Biochemical journal, 1995, Jun-01, Volume: 308 ( Pt 2)

    Topics: Escherichia coli; Hexosamines; N-Acetylneuraminic Acid; Oxo-Acid-Lyases; Phosphoenolpyruvate; Pyruvates; Sialic Acids

1995
Effects of chronic ethanol on enzymes regulating sialylation and desialylation of transferrin in rats.
    Alcoholism, clinical and experimental research, 1993, Volume: 17, Issue:3

    Topics: Alcoholism; Animals; beta-D-Galactoside alpha 2-6-Sialyltransferase; Glycosylation; Hexosamines; Leucine; Liver; Male; N-Acetylneuraminic Acid; Neuraminidase; Rats; Rats, Wistar; Sialic Acids; Sialyltransferases; Transferrin

1993
Utilization of sialic acid by viridans streptococci.
    Journal of dental research, 1996, Volume: 75, Issue:8

    Topics: Acetylglucosamine; Aldose-Ketose Isomerases; Amidohydrolases; Carbohydrate Epimerases; Culture Media; Deamination; Glucose; Hexosamines; Isomerism; Lactates; N-Acetylneuraminic Acid; Neuraminidase; Oxo-Acid-Lyases; Phosphorylation; Pyruvates; Streptococcus; Streptococcus oralis; Streptococcus sanguis

1996
An efficient process for production of N-acetylneuraminic acid using N-acetylneuraminic acid aldolase.
    Enzyme and microbial technology, 1997, Volume: 20, Issue:5

    Topics: 1-Propanol; Acetylglucosamine; Base Sequence; Biotransformation; Crystallization; DNA Primers; Enzymes, Immobilized; Escherichia coli; Hexosamines; N-Acetylneuraminic Acid; Oxo-Acid-Lyases; Pyruvic Acid; Recombinant Proteins; Solvents; Time Factors

1997
Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis.
    Science (New York, N.Y.), 1997, May-16, Volume: 276, Issue:5315

    Topics: Avidin; Biotin; Cell Membrane; Flow Cytometry; Glycoconjugates; HeLa Cells; Hexosamines; HL-60 Cells; Humans; Jurkat Cells; Ketones; N-Acetylneuraminic Acid; Neuraminidase; Oligosaccharides; Ricin; Tunicamycin

1997
Sialic acid utilisation by viridans streptococci.
    Advances in experimental medicine and biology, 1997, Volume: 418

    Topics: Glucose; Hexosamines; Humans; Isomerism; N-Acetylneuraminic Acid; Neuraminidase; Phosphorylation; Species Specificity; Streptococcal Infections; Streptococcus; Virulence

1997
Long-term ethanol consumption selectively impairs ganglioside pathway in rat brain.
    Alcoholism, clinical and experimental research, 1998, Volume: 22, Issue:6

    Topics: Alcoholism; Animals; Brain; Ethanol; Gangliosides; Glycosylation; Hexosamines; Male; N-Acetylneuraminic Acid; Neuraminidase; Rats; Rats, Wistar; Sialyltransferases; Subcellular Fractions

1998
Convergent pathways for utilization of the amino sugars N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminic acid by Escherichia coli.
    Journal of bacteriology, 1999, Volume: 181, Issue:1

    Topics: Acetylglucosamine; Aldose-Ketose Isomerases; Bacterial Proteins; Biological Transport, Active; Chromosome Mapping; Escherichia coli; Escherichia coli Proteins; Genes, Bacterial; Hexosamines; Membrane Proteins; Membrane Transport Proteins; Mutation; N-Acetylneuraminic Acid; Operon; Phosphoenolpyruvate Sugar Phosphotransferase System; Phosphorylation

1999
Aberrant metabolic sialylation of recombinant proteins expressed in Chinese hamster ovary cells in high productivity cultures.
    Biochemical and biophysical research communications, 1999, Apr-29, Volume: 258, Issue:1

    Topics: Animals; Cell Culture Techniques; CHO Cells; Chromatography, Affinity; Chromatography, High Pressure Liquid; Cricetinae; Hexosamines; N-Acetylneuraminic Acid; Recombinant Proteins

1999
N-acetylneuraminic acid transport by Streptococcus oralis strain AR3.
    Journal of medical microbiology, 1999, Volume: 48, Issue:4

    Topics: 2,4-Dinitrophenol; Acetylglucosamine; Anti-Bacterial Agents; Arsenates; Biological Transport; Chlorhexidine; Endocarditis, Bacterial; Hexosamines; Humans; Kinetics; Monosaccharides; N-Acetylneuraminic Acid; Proton-Motive Force; Reproducibility of Results; Sodium Azide; Sodium Fluoride; Streptococcal Infections; Streptococcus oralis; Uncoupling Agents

1999
Metabolic labeling of glycoproteins with chemical tags through unnatural sialic acid biosynthesis.
    Methods in enzymology, 2000, Volume: 327

    Topics: Animals; Biochemistry; Cell Line; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Flow Cytometry; Glycoproteins; HeLa Cells; Hexosamines; Humans; Jurkat Cells; Ketones; Microscopy, Fluorescence; Models, Biological; N-Acetylneuraminic Acid; Substrate Specificity; Time Factors

2000
Metabolic control of recombinant protein N-glycan processing in NS0 and CHO cells.
    Biotechnology and bioengineering, 2001, May-05, Volume: 73, Issue:3

    Topics: Animals; Bioreactors; Cell Division; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Galactose; Glucosamine; Glycosylation; Hexosamines; Mice; N-Acetylneuraminic Acid; Nucleotides; Polysaccharides; Recombinant Proteins; Sialyltransferases; Tissue Inhibitor of Metalloproteinase-1; Tumor Cells, Cultured

2001
Biosynthesis of N-acetylneuraminic acid in cells lacking UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase.
    Biological chemistry, 2001, Volume: 382, Issue:2

    Topics: Acetylgalactosamine; Acetylglucosamine; Carbohydrate Epimerases; Cells, Cultured; Clone Cells; Cytidine Monophosphate N-Acetylneuraminic Acid; Escherichia coli Proteins; Hexosamines; Humans; Lymphoma, B-Cell; N-Acetylneuraminic Acid; Phosphotransferases (Alcohol Group Acceptor)

2001
Substrate specificity of the sialic acid biosynthetic pathway.
    Biochemistry, 2001, Oct-30, Volume: 40, Issue:43

    Topics: Carbon; Cell Nucleus; Cytosol; Dose-Response Relationship, Drug; HeLa Cells; Hexosamines; HL-60 Cells; Humans; Jurkat Cells; Ketones; Mass Spectrometry; Models, Biological; Models, Chemical; N-Acetylneuraminic Acid; Phosphorylation; Protein Binding; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Time Factors

2001
Cloning, over-expression, purification, and characterisation of N-acetylneuraminate synthase from Streptococcus agalactiae.
    Protein expression and purification, 2003, Volume: 27, Issue:2

    Topics: Ammonium Sulfate; Bacillus subtilis; Catalysis; Chromatography; Chromatography, Gel; Cloning, Molecular; Databases as Topic; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Hexosamines; Hydrogen-Ion Concentration; Ions; Metals; N-Acetylneuraminic Acid; Oxo-Acid-Lyases; Phenylglyoxal; Phosphoenolpyruvate; Plasmids; Protein Binding; Protein Structure, Tertiary; Spectrometry, Mass, Electrospray Ionization; Streptococcus agalactiae; Substrate Specificity; Temperature; Thiobarbituric Acid Reactive Substances; Time Factors

2003
N-Acetylmannosamine-6-phosphate and N-acetylneuraminic acid-9-phosphate as intermediates in sialic acid biosynthesis.
    Biochemical and biophysical research communications, 1961, Jun-28, Volume: 5

    Topics: Hexosamines; Hexosephosphates; N-Acetylneuraminic Acid; Neuraminic Acids; Phosphates; Sialic Acids; Sugar Phosphates

1961
Preparation of N-acetyl-neuraminic acid from N-acetyl-D-mannosamine.
    Biochimica et biophysica acta, 1960, Mar-25, Volume: 39

    Topics: Amino Sugars; Hexosamines; N-Acetylneuraminic Acid; Neuraminic Acids

1960
Lec3 Chinese hamster ovary mutants lack UDP-N-acetylglucosamine 2-epimerase activity because of mutations in the epimerase domain of the Gne gene.
    The Journal of biological chemistry, 2003, Dec-26, Volume: 278, Issue:52

    Topics: Amino Acid Sequence; Animals; Blotting, Northern; Blotting, Western; Carbohydrate Epimerases; Cell Adhesion; Cell Line; Cell Separation; CHO Cells; Cricetinae; Culture Media, Serum-Free; DNA, Complementary; Flow Cytometry; Genetic Complementation Test; Glycosylation; Hexosamines; Humans; Lectins; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Mutation, Missense; N-Acetylneuraminic Acid; Phenotype; Plasmids; Point Mutation; Protein Structure, Tertiary; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sequence Homology, Amino Acid; Transfection

2003
The first committed step in the biosynthesis of sialic acid by Escherichia coli K1 does not involve a phosphorylated N-acetylmannosamine intermediate.
    Molecular microbiology, 2003, Volume: 50, Issue:3

    Topics: Bacterial Proteins; Carbohydrate Epimerases; Carrier Proteins; Cloning, Molecular; Escherichia coli; Escherichia coli Proteins; Hexosamines; Histidine; Magnetic Resonance Spectroscopy; Mutation; N-Acetylneuraminic Acid; Oxo-Acid-Lyases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Sialyltransferases

2003
Engineering sialic acid synthetic ability into insect cells: identifying metabolic bottlenecks and devising strategies to overcome them.
    Biochemistry, 2003, Dec-30, Volume: 42, Issue:51

    Topics: Acetylglucosamine; Animals; Carbohydrate Epimerases; Carbohydrate Sequence; Cells, Cultured; Culture Media, Conditioned; Hexosamines; Humans; Molecular Sequence Data; Moths; N-Acetylneuraminic Acid; Nucleopolyhedroviruses; Phosphotransferases (Alcohol Group Acceptor); Protein Engineering; Spodoptera; Sugar Acids; Transfection

2003
Characterization of the metabolic flux and apoptotic effects of O-hydroxyl- and N-acyl-modified N-acetylmannosamine analogs in Jurkat cells.
    The Journal of biological chemistry, 2004, Apr-30, Volume: 279, Issue:18

    Topics: Apoptosis; Cell Division; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; Hexosamines; Humans; Jurkat Cells; Metabolism; N-Acetylneuraminic Acid; Structure-Activity Relationship

2004
Metabolic installation of thiols into sialic acid modulates adhesion and stem cell biology.
    Nature chemical biology, 2006, Volume: 2, Issue:3

    Topics: beta Catenin; Cell Adhesion; Cell Differentiation; Cell Membrane; Gold; Hexosamines; Humans; Jurkat Cells; Ligands; Molecular Conformation; N-Acetylneuraminic Acid; Stem Cells; Sulfhydryl Compounds; Surface Properties; Up-Regulation

2006
Giving cells a new sugar-coating.
    Nature chemical biology, 2006, Volume: 2, Issue:3

    Topics: Cell Membrane; Cells; Hexosamines; Humans; Ligands; Molecular Structure; N-Acetylneuraminic Acid; Receptors, Cell Surface; Sulfhydryl Compounds

2006
Preparation of a fluorous protecting group and its application to the chemoenzymatic synthesis of sialidase inhibitor.
    Chemical communications (Cambridge, England), 2006, Aug-07, Issue:29

    Topics: Enzyme Inhibitors; Hexosamines; Molecular Structure; N-Acetylneuraminic Acid; Neuraminidase; Oxo-Acid-Lyases

2006
Engineering the sialic acid in organs of mice using N-propanoylmannosamine.
    Biochimica et biophysica acta, 2007, Volume: 1770, Issue:2

    Topics: Animals; Brain; Cell Membrane; Flow Cytometry; Genetic Engineering; Hexosamines; Liver; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Myocardium; N-Acetylneuraminic Acid; Organ Specificity; Subcellular Fractions

2007
Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Feb-20, Volume: 104, Issue:8

    Topics: Alkynes; Azides; Biotinylation; Cell Extracts; Cell Line, Tumor; Fluorescent Dyes; Fucose; Glycoconjugates; Hexosamines; Humans; Jurkat Cells; Molecular Probes; N-Acetylneuraminic Acid

2007
Sizing up sialic acid in glomerular disease.
    The Journal of clinical investigation, 2007, Volume: 117, Issue:6

    Topics: Animals; Disease Models, Animal; Female; Hexosamines; Humans; Kidney Diseases; Kidney Glomerulus; Mice; Mice, Mutant Strains; Models, Biological; Multienzyme Complexes; N-Acetylneuraminic Acid; Pregnancy

2007
Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine.
    The Journal of clinical investigation, 2007, Volume: 117, Issue:6

    Topics: Animals; Base Sequence; Disease Models, Animal; DNA Primers; Female; Hexosamines; Humans; Kidney Diseases; Kidney Glomerulus; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mice, Transgenic; Microscopy, Electron; Models, Biological; Multienzyme Complexes; N-Acetylneuraminic Acid; Pregnancy; Proteinuria

2007
Purification and characterization of GlcNAc-6-P 2-epimerase from Escherichia coli K92.
    Acta biochimica Polonica, 2007, Volume: 54, Issue:2

    Topics: Amino Acid Sequence; Bacteria; Base Sequence; Carbohydrate Epimerases; Cations; DNA, Bacterial; Escherichia coli; Hexosamines; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Molecular Weight; N-Acetylneuraminic Acid; Peptide Fragments; Sequence Homology, Amino Acid; Substrate Specificity

2007
A crosslinked inclusion body process for sialic acid synthesis.
    Journal of biotechnology, 2008, Mar-20, Volume: 134, Issue:1-2

    Topics: Biosensing Techniques; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Enzymes, Immobilized; Flow Cytometry; Glutaral; Hexosamines; Inclusion Bodies; N-Acetylneuraminic Acid; Oxo-Acid-Lyases; Substrate Specificity

2008
Coupled bioconversion for preparation of N-acetyl-D: -neuraminic acid using immobilized N-acetyl-D: -glucosamine-2-epimerase and N-acetyl-D: -neuraminic acid lyase.
    Applied microbiology and biotechnology, 2010, Volume: 85, Issue:5

    Topics: Acetylglucosamine; Bioreactors; Carbohydrate Epimerases; Carrier Proteins; Catalysis; Cloning, Molecular; DNA, Bacterial; Enzymes, Immobilized; Escherichia coli; Hexosamines; Hydrogen-Ion Concentration; Kinetics; N-Acetylneuraminic Acid; Oxo-Acid-Lyases; Pyruvic Acid; Recombinant Proteins

2010
Lessons from GNE-deficient embryonic stem cells: sialic acid biosynthesis is involved in proliferation and gene expression.
    Glycobiology, 2010, Volume: 20, Issue:1

    Topics: Alleles; Animals; Cell Proliferation; Embryonic Stem Cells; Gene Expression; Gene Expression Regulation, Developmental; Genotype; Hexosamines; Mice; N-Acetylneuraminic Acid; Oligonucleotide Array Sequence Analysis; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction

2010
Metabolism of diazirine-modified N-acetylmannosamine analogues to photo-cross-linking sialosides.
    Bioconjugate chemistry, 2011, Sep-21, Volume: 22, Issue:9

    Topics: Carbohydrate Conformation; Cell Membrane; Cholera Toxin; Cross-Linking Reagents; Cytosol; Diazomethane; G(M1) Ganglioside; Gangliosides; Glycoconjugates; Glycolipids; Glycoproteins; Hexosamines; Humans; Jurkat Cells; N-Acetylneuraminic Acid; Sialic Acid Binding Ig-like Lectin 2; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship; Ultraviolet Rays

2011
Peracetylated N-acetylmannosamine, a synthetic sugar molecule, efficiently rescues muscle phenotype and biochemical defects in mouse model of sialic acid-deficient myopathy.
    The Journal of biological chemistry, 2012, Jan-20, Volume: 287, Issue:4

    Topics: Animals; Disease Models, Animal; Distal Myopathies; Hexosamines; Humans; Mice; Mice, Transgenic; Muscle, Skeletal; N-Acetylneuraminic Acid

2012
The Gne M712T mouse as a model for human glomerulopathy.
    The American journal of pathology, 2012, Volume: 180, Issue:4

    Topics: Animals; Biomarkers; Carbohydrate Epimerases; Carrier Proteins; Dietary Supplements; Disease Models, Animal; Drug Evaluation, Preclinical; Hexosamines; Humans; Kidney Diseases; Kidney Glomerulus; Membrane Proteins; Mice; Mice, Mutant Strains; Microscopy, Electron; Mutation; N-Acetylneuraminic Acid; Podocytes; Real-Time Polymerase Chain Reaction; Sialoglycoproteins

2012
Crystal structures of N-acetylmannosamine kinase provide insights into enzyme activity and inhibition.
    The Journal of biological chemistry, 2012, Apr-20, Volume: 287, Issue:17

    Topics: Aspartic Acid; Binding Sites; Cell Membrane; Crystallography, X-Ray; Dimerization; Enzyme Inhibitors; Escherichia coli; Glycoconjugates; Glycoproteins; Hexosamines; Humans; N-Acetylneuraminic Acid; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Folding; Protein Structure, Secondary; Recombinant Proteins; Zinc

2012
Metabolic monosaccharides altered cell responses to anticancer drugs.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2012, Volume: 81, Issue:2

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Cell Communication; Cell Line, Tumor; CHO Cells; Cricetinae; Daunorubicin; Drug Resistance, Neoplasm; Fluorouracil; Hexosamines; Mice; Monosaccharides; N-Acetylneuraminic Acid; NIH 3T3 Cells; Polysaccharides; Signal Transduction

2012
Regulation of neuraminidase expression in Streptococcus pneumoniae.
    BMC microbiology, 2012, Sep-11, Volume: 12

    Topics: Gene Expression Profiling; Gene Expression Regulation, Bacterial; Hexosamines; Humans; N-Acetylneuraminic Acid; Neuraminidase; Operon; Streptococcus pneumoniae

2012
Impact of a human CMP-sialic acid transporter on recombinant glycoprotein sialylation in glycoengineered insect cells.
    Glycobiology, 2013, Volume: 23, Issue:2

    Topics: Animals; Cell Line; Cytidine Monophosphate N-Acetylneuraminic Acid; Genetic Vectors; Glycoproteins; Glycosylation; Hexosamines; Humans; Insecta; N-Acetylneuraminic Acid; Nucleotide Transport Proteins; Organic Anion Transporters; Protein Processing, Post-Translational; Recombinant Proteins; Spodoptera; Symporters

2013
Bioengineering of bacterial polymer inclusions catalyzing the synthesis of N-acetylneuraminic acid.
    Applied and environmental microbiology, 2013, Volume: 79, Issue:9

    Topics: Bacterial Proteins; Biocatalysis; Bioengineering; Carbohydrate Epimerases; Carrier Proteins; Escherichia coli; Gene Expression; Hexosamines; Hydrogen-Ion Concentration; Microspheres; N-Acetylneuraminic Acid; Oxo-Acid-Lyases; Polyhydroxyalkanoates; Polymers; Pyruvic Acid; Recombinant Fusion Proteins; Synechocystis

2013
Non-specific accumulation of glycosphingolipids in GNE myopathy.
    Journal of inherited metabolic disease, 2014, Volume: 37, Issue:2

    Topics: Animals; Case-Control Studies; Cells, Cultured; Female; Fibroblasts; Glycosphingolipids; Hexosamines; Humans; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Muscles; Muscular Diseases; Mutation; N-Acetylneuraminic Acid

2014
Substrate-mediated control of the conformation of an ancillary domain delivers a competent catalytic site for N-acetylneuraminic acid synthase.
    Proteins, 2014, Volume: 82, Issue:9

    Topics: Binding Sites; Catalytic Domain; Chromatography, Gel; Crystallography, X-Ray; Hexosamines; Hydrogen Bonding; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; N-Acetylneuraminic Acid; Neisseria meningitidis; Oxo-Acid-Lyases; Phosphoenolpyruvate; Protein Structure, Quaternary

2014
Sialyllactose ameliorates myopathic phenotypes in symptomatic GNE myopathy model mice.
    Brain : a journal of neurology, 2014, Volume: 137, Issue:Pt 10

    Topics: Aging; Amyloid beta-Peptides; Animals; Body Weight; Cells, Cultured; Creatine Kinase; Disease Models, Animal; Distal Myopathies; Enzyme-Linked Immunosorbent Assay; Hexosamines; Lactose; Mice; Muscle Contraction; Muscle, Skeletal; Mutation; Myoblasts; N-Acetylneuraminic Acid; Peptide Fragments; Phenotype

2014
A novel approach to decrease sialic acid expression in cells by a C-3-modified N-acetylmannosamine.
    The Journal of biological chemistry, 2014, Nov-14, Volume: 289, Issue:46

    Topics: Carbohydrate Epimerases; Carrier Proteins; Chromatography, High Pressure Liquid; Cloning, Molecular; Cytosol; Dose-Response Relationship, Drug; Flow Cytometry; Hexosamines; Humans; Jurkat Cells; Kinetics; Lectins; N-Acetylneuraminic Acid; Phosphotransferases (Alcohol Group Acceptor); Protein Binding; Scattering, Radiation; Substrate Specificity; Surface Plasmon Resonance

2014
Characterization of a novel N-acetylneuraminic acid lyase favoring industrial N-acetylneuraminic acid synthesis.
    Scientific reports, 2015, 03-23, Volume: 5

    Topics: Amino Acid Sequence; Bacterial Proteins; Biocatalysis; Cloning, Molecular; Corynebacterium glutamicum; Escherichia coli; Gene Expression; Hexosamines; Hydro-Lyases; Kinetics; Molecular Sequence Data; N-Acetylneuraminic Acid; Oxo-Acid-Lyases; Phylogeny; Pyruvic Acid; Recombinant Proteins; Sequence Alignment; Substrate Specificity

2015
Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss.
    Nature communications, 2015, Mar-31, Volume: 6

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bone and Bones; Bone Resorption; Cell Differentiation; Dynamic Light Scattering; Female; Galactose; Glycosylation; Hexosamines; Humans; Immunoglobulin Fc Fragments; Immunoglobulin G; Male; Mice; Middle Aged; N-Acetylneuraminic Acid; Osteoclasts; Receptors, Fc; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; X-Ray Microtomography

2015
Quantitative hydrophilic interaction chromatography-mass spectrometry analysis of N-acetylneuraminic acid and N-acetylmannosamine in human plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2015, Sep-01, Volume: 1000

    Topics: Chromatography, Liquid; Drug Stability; Hexosamines; Humans; Hydrophobic and Hydrophilic Interactions; N-Acetylneuraminic Acid; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry

2015
A novel sugar analog enhances sialic acid production and biotherapeutic sialylation in CHO cells.
    Biotechnology and bioengineering, 2017, Volume: 114, Issue:8

    Topics: Animals; CHO Cells; Cricetulus; Culture Media; Erythropoietin; Hexosamines; N-Acetylneuraminic Acid; Oligosaccharides; Protein Engineering; Recombinant Proteins

2017
The Nitrogen Regulatory PII Protein (GlnB) and
    Journal of bacteriology, 2018, 03-01, Volume: 200, Issue:5

    Topics: Acetylglucosamine; Aldose-Ketose Isomerases; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Glucosamine; Glucose-6-Phosphate; Hexosamines; N-Acetylneuraminic Acid; Nitrogen; Phosphorylation; PII Nitrogen Regulatory Proteins; Protein Interaction Mapping; Racemases and Epimerases; Signal Transduction; Transcription Factors

2018
Enhancement of glycosylation by stable co-expression of two sialylation-related enzymes on Chinese hamster ovary cells.
    Journal of bioscience and bioengineering, 2018, Volume: 126, Issue:1

    Topics: Animals; Carbohydrate Epimerases; CHO Cells; Cricetinae; Cricetulus; Gene Expression Regulation, Enzymologic; Genetic Vectors; Glycosylation; Hexosamines; N-Acetylneuraminic Acid; Polysaccharides; Protein Engineering; Protein Processing, Post-Translational; Recombinant Proteins; Sialyltransferases; Transfection

2018
Integration of genetic and metabolic features related to sialic acid metabolism distinguishes human breast cell subtypes.
    PloS one, 2018, Volume: 13, Issue:5

    Topics: Biomarkers, Tumor; Breast Neoplasms; Cell Proliferation; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glycosylation; Hexosamines; Humans; N-Acetylneuraminic Acid; Tumor Cells, Cultured

2018
Sialic acid glycoengineering using N-acetylmannosamine and sialic acid analogs.
    Glycobiology, 2019, 06-01, Volume: 29, Issue:6

    Topics: Animals; Carbohydrate Conformation; Hexosamines; Humans; Metabolic Engineering; N-Acetylneuraminic Acid

2019
Time and space-resolved quantification of plasma membrane sialylation for measurements of cell function and neurotoxicity.
    Archives of toxicology, 2020, Volume: 94, Issue:2

    Topics: Bortezomib; Cell Line; Cell Membrane; Drug Evaluation, Preclinical; Glycoconjugates; Green Fluorescent Proteins; Hexosamines; Humans; Molecular Biology; N-Acetylneuraminic Acid; Neurites; Neurons; Neurotoxicity Syndromes; Tunicamycin

2020
Hyposialylated angiopoietin-like-4 induces apoptosis of podocytes via β1 Integrin/FAK signaling in diabetic nephropathy.
    Molecular and cellular endocrinology, 2020, 04-05, Volume: 505

    Topics: Actin Cytoskeleton; Angiopoietin-Like Protein 4; Animals; Apoptosis; Cell Line; Cell Line, Transformed; Diabetic Nephropathies; Focal Adhesion Protein-Tyrosine Kinases; Glucose; Hexosamines; Humans; Hyperglycemia; Integrin beta1; Male; Mice, Inbred C57BL; N-Acetylneuraminic Acid; Podocytes; Rats, Sprague-Dawley; Signal Transduction; Up-Regulation

2020
Glycoengineering Human Neural and Adipose Stem Cells with Novel Thiol-Modified
    Cells, 2021, 02-12, Volume: 10, Issue:2

    Topics: Adipocytes; Cell Differentiation; Glycoconjugates; Hexosamines; Humans; N-Acetylneuraminic Acid; Stem Cells; Sulfhydryl Compounds

2021