n-acetylneuraminic acid has been researched along with 2-deoxy-2,3-dehydro-n-acetylneuraminic acid in 109 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (9.17) | 18.7374 |
| 1990's | 32 (29.36) | 18.2507 |
| 2000's | 36 (33.03) | 29.6817 |
| 2010's | 26 (23.85) | 24.3611 |
| 2020's | 5 (4.59) | 2.80 |
| Authors | Studies |
|---|---|
| Bethell, R; Cherry, PC; Cleasby, A; Colman, P; Howes, PD; Singh, O; Skarzynski, T; Smith, PW; Sollis, SL; Taylor, NR; Varghese, J; Wonacott, AJ | 1 |
| Bourguet, E; Figurska, S; Fra Czek, MM | 1 |
| Cairo, CW; Guo, T; Hunter, CD; Richards, MR | 1 |
| Caldwell, JB; Colman, PM; Kortt, AA; McKimm-Breschkin, JL; Varghese, JN | 1 |
| Cabezas, JA; Cobaleda, C; García Sastre, A; Villar, E | 1 |
| Louie, A; Potier, M; Ribeiro, A; Warner, TG | 1 |
| Kleineidam, RG; Schauer, R; Schreiner, E; Zbiral, E | 1 |
| Becker, PJ; du Plessis, DJ; van Aswegen, CH; van Rensburg, HG; Wittliff, JL | 1 |
| el-Fakahany, EE; Fryer, AD; Jacoby, DB | 1 |
| Saito, M; Yu, RK | 2 |
| Bratt, MA; Glickman, RL; Iorio, RM; Riel, AM; Sheehan, JP; Syddall, RJ | 1 |
| Sweeley, CC; Usuki, S | 1 |
| Hoops, P; Sweeley, CC; Usuki, S | 1 |
| Air, GM; Baker, AT; Colman, PM; Laver, WG; Metzger, DW; Varghese, JN; Webster, RG | 1 |
| Waxham, MN; Wolinsky, JS | 1 |
| Rosenberg, A; Saito, M | 1 |
| Schauer, R; Tschesche, H; Wember, M | 1 |
| Michalski, JC; Montreuil, J; Strecker, G | 1 |
| Beau, JM; Nöhle, U; Schauer, R | 1 |
| Kawaoka, Y; Kobayashi, M; Suzuki, T; Suzuki, Y; Tsukimoto, M; Webster, RG; Yamada, A | 1 |
| Air, GM; Brouillette, WJ; Jedrzejas, MJ; Laver, WG; Luo, M; Singh, S | 2 |
| Mononen, I; Romppanen, J | 1 |
| Bellini, T; Dallocchio, F; Tomasi, M | 1 |
| Air, GM; Janakiraman, MN; Laver, WG; Luo, M; White, CL | 1 |
| Bosso, C; Burmeister, WP; Cusack, S; Henrissat, B; Ruigrok, RW | 1 |
| Cantz, M; Kopitz, J; Mühl, C; von Reitzenstein, C | 1 |
| Corfield, T | 1 |
| Bennett, G; Burnier, J; Chang, J; Ferrari, J; Harris, R; McNerney, T; Sliwkowski, MB; Warner, TG | 1 |
| Holzer, CT; Jin, B; Pegg, MS; Stewart, WP; von Itzstein, M; Wu, WY | 1 |
| Air, GM; Babu, YS; Bossart-Whitaker, P; Carson, M; Laver, WG; Smith, CD | 1 |
| Taylor, G | 1 |
| Achiwa, K; Ikeda, K; Murakami, M | 1 |
| Crennell, SJ; Garman, EF; Laver, WG; Philippon, C; Taylor, GL; Vasella, A; Vimr, ER | 1 |
| Hasan, MK; Hu, H; Miyake, K; Moriya, C; Nagai, Y; Shimada, T; Shioda, T; Xin, X | 1 |
| Inoue, S; Inoue, Y; Kitajima, K; Kong, DC; Norton, AK; Terada, T; Thomson, RJ; von Itzstein, M; Wilson, JC | 1 |
| Cantz, M; Ehemann, V; Kopitz, J; Lehmann, C; Mühl, C | 1 |
| Bethell, RC; Blick, TJ; Colman, PM; Hart, GJ; McDonald, M; McKimm-Breschkin, JL; Sahasrabudhe, A; Varghese, JN | 1 |
| Barnett, JM; Hiscox, SA; Morris, SJ; Price, GE; Smith, H; Sweet, C | 1 |
| Beighton, D; Byers, HL; Homer, KA; Tarelli, E | 1 |
| Kajihara, Y; Kamei, H; Nishi, Y | 1 |
| Abo, S; Alafaci, A; Florio, P; Thomson, RJ; von Itzstein, M | 1 |
| Brossmer, R; Greengard, O; Jordan, M; Levin Perlman, S; Moscona, A | 1 |
| Barbosa, JA; Brossmer, R; Campi, EM; DeGori, R; Jackson, WR; Lawrence, MC; Marcuccio, SM; Ooi, HC; Smith, BJ; Sommer, M | 1 |
| Crennell, S; Portner, A; Takimoto, T; Taylor, G | 1 |
| Hidari, K; Ikeda, K; Ito, M; Saito, M; Sano, K; Suzuki, T; Suzuki, Y; Tanaka, K | 1 |
| Azuma, Y; Matsumoto, K; Taniguchi, A | 1 |
| Colman, PM; Danylec, B; Smith, BJ; Varghese, JN; Von Itzstein, M | 1 |
| Bellini, T; Dallocchio, F; Manfrinato, MC; Masserini, M; Tomasi, M | 1 |
| Kamei, H; Nishi, Y; Shimazaki, K | 1 |
| Hosokawa, C; Ikeda, K; Jwa Hidari, KI; Kogure, T; Koyama, N; Miyamoto, D; Suzuki, T; Suzuki, Y; Takahashi, T; Tanaka, K | 1 |
| Arai, M; Honda, T; Kobayashi, Y; Masuda, T; Yamashita, M; Yoshida, S | 1 |
| Arai, M; Honda, T; Masuda, T; Yamashita, M; Yoshida, S | 1 |
| Codd, R; Lay, PA | 1 |
| Fujii, S; Hidari, KI; Li, YT; Miyamoto, D; Murakami, M; Nishinaka, D; Suzuki, T; Suzuki, Y; Takahashi, T | 1 |
| Coppel, RL; Haselhorst, T; McAtamney, S; Menting, JG; Thomson, RJ; von Itzstein, M; Wilson, JC | 1 |
| Connaris, H; Kiefel, MJ; Moustafa, I; Taylor, G; Taylor, M; von Itzstein, M; Wilson, JC; Zaitsev, V | 1 |
| Doi, N; Fujii, M; Kijimoto-Ochiai, S; Matsukawa, H; Tomobe, K | 1 |
| Bharara, R; Chitnis, CE; Pattnaik, P; Sharma, A; Singh, S | 1 |
| Chavas, LM; Fusi, P; Kato, R; Monti, E; Tettamanti, G; Tringali, C; Venerando, B; Wakatsuki, S | 1 |
| Alzari, PM; Amaya, MF; Frasch, AC; Nguyen, T; Paris, G; Ratier, L | 1 |
| Franke, D; Hong, Z; Hsu, CC; Wada, M; Wong, CH | 1 |
| Jakubczak, A; Rudaś, P; Wolska, K | 1 |
| Alymova, I; Dyason, JC; Portner, A; Ryan, C; Taylor, G; Thomson, RJ; Tindal, DJ; von Itzstein, M; Zaitsev, V | 1 |
| Chou, KC; Du, QS; Sun, H; Wei, DQ | 1 |
| Ikeda, K; Mori, H; Sato, M | 1 |
| Ikeda, K; Kitani, S; Maki, N; Sato, K; Sato, M; Suzuki, T; Suzuki, Y | 1 |
| Blanchard, H; Coulson, BS; Dyason, JC; Fleming, F; Frank, M; Haselhorst, T; Holloway, G; Kiefel, MJ; Kraschnefski, MJ; Szyczew, AJ; von Itzstein, M | 1 |
| Brown, DR; Hunt, ME | 1 |
| Brown, DR; Kleven, SH; May, M | 1 |
| Gervay-Hague, J; Horn, EJ; Saludes, JP | 1 |
| Ando, M; Furuhata, K; Kannappan, R; Uda, Y | 1 |
| Chang, YC; Ha, KT; Jin, UH; Kim, CH; Kim, KW; Ko, JH; Lee, YC | 1 |
| Aoyama, S; Ikeda, K; Nishino, R; Sato, K; Sato, M; Suzuki, T | 1 |
| Andrew, PW; Li, X; Taylor, GL; Xu, G | 1 |
| Andrew, PW; Oggioni, MR; Potter, JA; Russell, RJ; Taylor, GL; Xu, G | 1 |
| Andrew, PW; Carter, M; Hayre, J; Iannelli, F; Kadioglu, A; Oggioni, MR; Pozzi, G; Trappetti, C | 1 |
| Gervay-Hague, J; Horn, EJ | 1 |
| Banerjee, A; Carlin, AF; Doran, KS; Hightower, G; Khosravi, A; Mitchell, TJ; Nizet, V; Quach, D; Uchiyama, S; Weiman, S | 1 |
| Isaev, DS; Isaeva, EV; Kostyuk, PG; Lushnikova, IV; Savrasova, AV; Skibo, GG | 1 |
| Holmes, GL; Isaev, D; Isaeva, E; Lushnikova, I; Savrasova, A; Skibo, G | 1 |
| Fukushima, K; Hayakawa, T; Hosokawa, C; Ikeda, K; Itoh, K; Suzuki, T; Takaguchi, M; Takahashi, T; Ueyama, H | 1 |
| Hayakawa, T; Ikeda, K; Nishino, R; Sato, M; Suzuki, T; Takahashi, T | 2 |
| Alymova, IV; Freiden, P; McCullers, JA; Mishin, VP; Portner, A; Taylor, GL | 1 |
| Barrett, S; McKimm-Breschkin, JL; Mohr, PG; Schmidt, PM | 1 |
| Atamas, SP; Cross, AS; Feng, C; Goldblum, SE; Guang, W; Huang, W; Hyun, SW; Lillehoj, EP; Liu, A; Luzina, IG; Miranda-Ribera, A; Nguyen, C; Passaniti, A; Puché, AC; Twaddell, WS; Wang, LX; Zhang, L | 1 |
| Alencar, N; Alves, CN; Govender, T; Kruger, HG; Lameira, J; Lima, AH; Maguire, GE; Souza, PR | 1 |
| Dyason, JC; Kerry, PS; Maggioni, A; Naffakh, N; Rameix-Welti, MA; Rose, FJ; Rudrawar, S; Russell, RJ; Thomson, RJ; van der Werf, S; von Itzstein, M | 1 |
| Bhatt, B; Smee, DF; Tarbet, EB; von Itzstein, M | 1 |
| Cavasotto, CN; Durland, RH; Elizondo-Riojas, MA; Englehardt, J; Gorenstein, DG; He, W; Li, X; Lokesh, GL; Somasunderam, A; Thiviyanathan, V; Volk, DE | 1 |
| Benčina, D; Benčina, M; Berčič, RL; Bisgaard, M; Christensen, H; Cizelj, I; Kastelic, S; Makrai, L; Narat, M; Zorman-Rojs, O | 1 |
| Albohy, A; Cairo, CW; Pshezhetsky, AV; Smutova, V; Zhang, Y; Zou, Y | 1 |
| Ahn, HJ; Kim, JH; Kim, MG; Kim, YW; Lee, DH; Park, KH; Woo, EJ | 1 |
| Dyason, JC; Maggioni, A; Rudrawar, S; Thomson, RJ; von Itzstein, M | 1 |
| Baud, S; Blaise, S; Dauchez, M; Debelle, L; Duca, L; Durlach, V; Garbar, C; Ghirardi, M; Heinz, A; Kawecki, C; Martiny, L; Maurice, P; Rabenoelina, F; Romier, B; Schmelzer, CE; Tarpin, M | 1 |
| Madge, PD; Pascolutti, M; Thomson, RJ; von Itzstein, M | 1 |
| Hikita, T; Ieno, D; Ikeda, K; Mamada, S; Minami, A; Otsubo, T; Saito, M; Suzuki, T; Takahashi, T | 1 |
| Araki, K; Chigwechokha, PK; Kamada, Y; Komatsu, M; Matsusaki, K; Shinyoshi, S; Shiozaki, K; Tepparin, S | 1 |
| Li, S; Ma, F; Mo, JM; Su, DM; Xiong, Y; Zhang, JG | 1 |
| Allen, WJ; Balius, TE; Fochtman, BC; Rizzo, RC | 1 |
| Liu, GJ; Wang, B; Wang, S; Xing, GW; Yang, X; Zhang, Y | 1 |
| Xiong, J; Xu, D; Zhang, C | 1 |
| Bailly, B; Chibanga, VP; Dirr, L; El-Deeb, IM; Guillon, P; Thomson, RJ; von Itzstein, M | 1 |
| Iwaki, Y; Kitajima, K; Matsunaga, E; Sato, C; Takegawa, K | 1 |
| Fujita, Y; Ikeda, K; Ishikawa, T; Kanazawa, H; Kaneko, YK; Kurebayashi, Y; Mikami, Y; Minami, A; Miyagi, T; Otsubo, T; Sawatani, T; Sekita, R; Shimba, S; Shiratori, M; Suzuki, T; Takahashi, T | 1 |
| Atamas, SP; Cairo, CW; Goldblum, SE; Hyun, SW; Imamura, A; Ishida, H; Lillehoj, EP; Lockatell, V; Lugkey, KN; Luzina, IG | 1 |
| Gomer, RH; Karhadkar, TR; Pilling, D | 1 |
2 review(s) available for n-acetylneuraminic acid and 2-deoxy-2,3-dehydro-n-acetylneuraminic acid
| Article | Year |
|---|---|
Human Neuraminidases: Structures and Stereoselective Inhibitors.
Topics: Amino Acid Sequence; Enzyme Inhibitors; Humans; Models, Molecular; Neuraminidase; Stereoisomerism; Structure-Activity Relationship | 2022 |
New antiviral approaches for human parainfluenza: Inhibiting the haemagglutinin-neuraminidase.
Topics: Antiviral Agents; Child; Child, Preschool; Drug Delivery Systems; Drug Design; Drug Resistance, Viral; Enzyme Inhibitors; Genome, Viral; HN Protein; Humans; Immunocompromised Host; N-Acetylneuraminic Acid; Neuraminidase; Parainfluenza Virus 1, Human; Parainfluenza Virus 3, Human; Paramyxoviridae Infections; Viral Proteins; Virus Internalization | 2019 |
107 other study(ies) available for n-acetylneuraminic acid and 2-deoxy-2,3-dehydro-n-acetylneuraminic acid
| Article | Year |
|---|---|
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.
Topics: Acetamides; Antiviral Agents; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Guanidines; Influenza A virus; Influenza B virus; Models, Molecular; Neuraminidase; Protein Conformation; Pyrans; Sialic Acids; Zanamivir | 1998 |
Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivity.
Topics: Amino Acid Sequence; Antiviral Agents; Binding Sites; Catalytic Domain; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Isoenzymes; Kinetics; Molecular Dynamics Simulation; Neuraminidase; Sequence Alignment; Viral Proteins; Zanamivir | 2018 |
The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor.
Topics: Fourier Analysis; Macromolecular Substances; N-Acetylneuraminic Acid; Neuraminidase; Orthomyxoviridae; Protein Conformation; Receptors, Virus; Sialic Acids; X-Ray Diffraction | 1992 |
On the inhibition mechanism of the sialidase activity from Newcastle disease virus.
Topics: Hemagglutination Inhibition Tests; Hemagglutination, Viral; HN Protein; Kinetics; N-Acetylneuraminic Acid; Neuraminic Acids; Neuraminidase; Newcastle disease virus; Sialic Acids | 1991 |
Distinguishing mammalian sialidases by inhibition kinetics with novel derivatives of 5-acetamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enonic acid, an unsaturated derivative of N-acetylneuraminic acid.
Topics: Adenoviridae; Animals; Cell Line, Transformed; Cell Membrane; Cell Transformation, Neoplastic; Fibroblasts; Humans; Kinetics; Lysosomes; Microsomes; Muscles; N-Acetylneuraminic Acid; Neuraminidase; Rats; Sialic Acids | 1991 |
2,3-Didehydro-2-deoxysialic acids structurally varied at C-5 and their behaviour towards the sialidase from Vibrio cholerae.
Topics: Kinetics; N-Acetylneuraminic Acid; Neuraminidase; Sialic Acids; Structure-Activity Relationship; Vibrio cholerae | 1991 |
Influence of sialic acid on the binding activity of estrogen receptors.
Topics: Animals; Aspirin; beta-D-Galactoside alpha 2-6-Sialyltransferase; Cytosol; Estradiol; Female; Molybdenum; N-Acetylneuraminic Acid; Neuraminidase; Papio; Receptors, Estrogen; Sialic Acids; Sialyltransferases; Uterus | 1990 |
Parainfluenza virus type 1 reduces the affinity of agonists for muscarinic receptors in guinea-pig lung and heart.
Topics: Animals; Carbachol; Cells, Cultured; Guinea Pigs; Hemagglutinins, Viral; In Vitro Techniques; Kinetics; Lung; Myocardium; N-Acetylneuraminic Acid; Neuraminidase; Parainfluenza Virus 1, Human; Paramyxoviridae Infections; Quinuclidinyl Benzilate; Receptors, Muscarinic; Sialic Acids | 1990 |
Further characterization of a myelin-associated neuraminidase: properties and substrate specificity.
Topics: alpha-Fetoproteins; Animals; Brain; Female; Gangliosides; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Lipids; Microsomes; Myelin Sheath; N-Acetylneuraminic Acid; Neuraminidase; Protein Denaturation; Rats; Rats, Inbred Strains; Sialic Acids; Substrate Specificity | 1986 |
Identification of amino acid residues important to the neuraminidase activity of the HN glycoprotein of Newcastle disease virus.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antigens, Viral; Base Sequence; Binding, Competitive; Chick Embryo; Epitopes; HN Protein; Molecular Sequence Data; N-Acetylneuraminic Acid; Neuraminidase; Newcastle disease virus; Sialic Acids | 1989 |
[Secretary sialidase activity and GM3 ganglioside].
Topics: Cell Cycle; Cells, Cultured; Fibroblasts; G(M3) Ganglioside; Hydrogen-Ion Concentration; Hydrolysis; Lactose; N-Acetylneuraminic Acid; Neuraminidase; Sialic Acids; Substrate Specificity | 1989 |
Growth control of human foreskin fibroblasts and inhibition of extracellular sialidase activity by 2-deoxy-2,3-dehydro-N-acetylneuraminic acid.
Topics: Cell Division; Cells, Cultured; DNA Replication; Fibroblasts; Humans; Kinetics; Male; N-Acetylneuraminic Acid; Neuraminidase; Sialic Acids; Skin | 1988 |
Antigenic structure and variation in an influenza virus N9 neuraminidase.
Topics: Antibodies, Monoclonal; Base Sequence; Binding Sites; Cross Reactions; Influenza A virus; Molecular Weight; N-Acetylneuraminic Acid; Neuraminidase; Protein Conformation; Sialic Acids | 1987 |
A fusing mumps virus variant selected from a nonfusing parent with the neuraminidase inhibitor 2-deoxy-2,3-dehydro-N-acetylneuraminic acid.
Topics: Animals; Cell Fusion; Cell Line; Cytopathogenic Effect, Viral; Genetic Variation; Hemagglutination, Viral; HN Protein; Molecular Weight; Mumps virus; N-Acetylneuraminic Acid; Neuraminidase; Sialic Acids; Viral Envelope Proteins; Viral Fusion Proteins; Viral Plaque Assay | 1986 |
Identification and characterization of N-acetyl-2,3-didehydro-2-deoxyneuraminic acid as a metabolite in mammalian brain.
Topics: Animals; Brain; Brain Chemistry; Cattle; Chromatography, Thin Layer; Gas Chromatography-Mass Spectrometry; Hexosamines; Hydrogenation; N-Acetylneuraminic Acid; Rats; Rats, Inbred Strains; Sialic Acids | 1984 |
Isolation and characterization of an oligosaccharide- and glycoprotein-specific sialidase from human leucocytes.
Topics: Blood Proteins; Chromatography; Electrophoresis, Disc; Glycoproteins; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Leukocytes; Molecular Weight; N-Acetylneuraminic Acid; Neuraminic Acids; Neuraminidase; Oligosaccharides; Sialic Acids; Substrate Specificity | 1984 |
A thin layer chromatographic technique for screening for sialuria.
Topics: Chromatography, Thin Layer; Humans; N-Acetylneuraminic Acid; Sialic Acids | 1983 |
Uptake, metabolism and excretion of orally and intravenously administered, double-labeled N-glycoloylneuraminic acid and single-labeled 2-deoxy-2,3-dehydro-N-acetylneuraminic acid in mouse and rat.
Topics: Administration, Oral; Animals; Injections, Intravenous; Intestinal Absorption; Kidney; Liver; Metabolic Clearance Rate; Mice; N-Acetylneuraminic Acid; Neuraminic Acids; Rats; Sialic Acids; Spleen | 1982 |
Sialoglycoproteins that bind influenza A virus and resist viral neuraminidase in different animal sera.
Topics: alpha-Fetoproteins; Animals; Antiviral Agents; Blotting, Western; Carbohydrate Sequence; Glycophorins; Humans; Influenza A virus; Molecular Sequence Data; N-Acetylneuraminic Acid; Neuraminidase; Protein Binding; Sensitivity and Specificity; Sialic Acids; Sialoglycoproteins | 1994 |
Structure-based inhibitors of influenza virus sialidase. A benzoic acid lead with novel interaction.
Topics: Anti-Infective Agents; Benzoates; Benzoic Acid; Crystallography, X-Ray; Influenza A virus; Influenza B virus; Magnetic Resonance Spectroscopy; N-Acetylneuraminic Acid; Neuraminidase; Sialic Acids; Structure-Activity Relationship | 1995 |
Age-related reference values for urinary excretion of sialic acid and deoxysialic acid: application to diagnosis of storage disorders of free sialic acid.
Topics: Adolescent; Adult; Aging; Carbohydrate Metabolism, Inborn Errors; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Infant; Middle Aged; N-Acetylneuraminic Acid; Reference Values; Sialic Acids | 1995 |
Structures of aromatic inhibitors of influenza virus neuraminidase.
Topics: Aminobenzoates; Animals; Binding Sites; Electrochemistry; Models, Molecular; Molecular Structure; N-Acetylneuraminic Acid; Neuraminidase; Nitrobenzoates; Orthomyxoviridae; Protein Conformation; Sialic Acids; Structure-Activity Relationship | 1995 |
Activation of the Sendai virus fusion protein by receptor binding.
Topics: Allantois; Animals; Chick Embryo; Erythrocytes; Hemolysis; Humans; Kinetics; N-Acetylneuraminic Acid; Neuraminidase; Parainfluenza Virus 1, Human; Receptors, Cell Surface; Sialic Acids; Viral Fusion Proteins | 1995 |
Structure of influenza virus neuraminidase B/Lee/40 complexed with sialic acid and a dehydro analog at 1.8-A resolution: implications for the catalytic mechanism.
Topics: Binding Sites; Catalysis; Crystallization; Crystallography, X-Ray; Influenza B virus; Lactose; Macromolecular Substances; Models, Molecular; Molecular Structure; N-Acetylneuraminic Acid; Neuraminidase; Protein Structure, Secondary; Sialic Acids | 1994 |
Influenza B virus neuraminidase can synthesize its own inhibitor.
Topics: Crystallography, X-Ray; Gas Chromatography-Mass Spectrometry; Influenza B virus; Models, Molecular; Molecular Conformation; N-Acetylneuraminic Acid; Neuraminidase; Protein Structure, Secondary; Sialic Acids | 1993 |
Role of plasma membrane ganglioside sialidase of human neuroblastoma cells in growth control and differentiation.
Topics: Acetylcholinesterase; Cell Differentiation; Cell Division; Cell Line; Cell Membrane; Glycodeoxycholic Acid; Humans; Kinetics; Lysosomes; N-Acetylneuraminic Acid; Neuraminidase; Neuroblastoma; Octoxynol; Ornithine Decarboxylase; Sialic Acids; Substrate Specificity; Tumor Cells, Cultured | 1994 |
Possible role of myelin-associated neuraminidase in membrane adhesion.
Topics: Animals; Cell Adhesion; Cell Membrane; Chromatography, Affinity; Chromium Radioisotopes; G(M1) Ganglioside; Glycolipids; Kinetics; Myelin Sheath; N-Acetylneuraminic Acid; Neuraminidase; Oligodendroglia; Rats; Rats, Sprague-Dawley; Sialic Acids | 1993 |
Tailor made sialidase inhibitors home in on influenza virus.
Topics: Antiviral Agents; Drug Design; Humans; Influenza, Human; N-Acetylneuraminic Acid; Neuraminidase; Orthomyxoviridae; Sialic Acids | 1993 |
Isolation and properties of a soluble sialidase from the culture fluid of Chinese hamster ovary cells.
Topics: Amino Acid Sequence; Animals; Carbohydrate Sequence; CHO Cells; Cricetinae; Enzyme Stability; Glycoconjugates; Hydrogen-Ion Concentration; Immunoblotting; Isoelectric Point; Kinetics; Molecular Sequence Data; Molecular Weight; N-Acetylneuraminic Acid; Neuraminidase; Peptide Fragments; Sialic Acids; Substrate Specificity | 1993 |
Inhibition of sialidases from viral, bacterial and mammalian sources by analogues of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid modified at the C-4 position.
Topics: Animals; Bacteria; Binding Sites; Influenza A virus; Influenza B virus; Molecular Structure; N-Acetylneuraminic Acid; Neuraminidase; Sheep; Sialic Acids | 1993 |
Three-dimensional structure of influenza A N9 neuraminidase and its complex with the inhibitor 2-deoxy 2,3-dehydro-N-acetyl neuraminic acid.
Topics: Binding Sites; Influenza A virus; Influenza B virus; Mercury; Models, Molecular; Molecular Conformation; N-Acetylneuraminic Acid; Neuraminidase; Platinum; Protein Conformation; Sialic Acids; X-Ray Diffraction | 1993 |
Drug design. A rational attack on influenza.
Topics: Antiviral Agents; Disease Outbreaks; Drug Design; Humans; Influenza, Human; N-Acetylneuraminic Acid; Neuraminidase; Sialic Acids | 1993 |
Chemoenzymatic synthesis of neuraminic acid analogs structurally varied at C-5 and C-9 as potential inhibitors of the sialidase from influenza virus.
Topics: Enzyme Inhibitors; Influenza A virus; Magnetic Resonance Spectroscopy; Mannose; Molecular Structure; N-Acetylneuraminic Acid; Neuraminidase; Oxo-Acid-Lyases; Pyruvates; Pyruvic Acid; Sialic Acids | 1996 |
The structures of Salmonella typhimurium LT2 neuraminidase and its complexes with three inhibitors at high resolution.
Topics: Binding Sites; Catalysis; Enzyme Inhibitors; Models, Molecular; N-Acetylneuraminic Acid; Neuraminidase; Protein Conformation; Salmonella typhimurium; Sialic Acids | 1996 |
Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface.
Topics: 1-Deoxynojirimycin; Animals; Cell Line; Enzyme Inhibitors; Glycoside Hydrolases; HeLa Cells; HIV-1; HIV-2; Humans; Lentivirus; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; N-Acetylneuraminic Acid; Neuraminidase; Simian Immunodeficiency Virus; Virion; Virus Replication | 1996 |
Catalysis by a new sialidase, deaminoneuraminic acid residue-cleaving enzyme (KDNase Sm), initially forms a less stable alpha-anomer of 3-deoxy-D-glycero-D-galacto-nonulosonic acid and is strongly inhibited by the transition state analogue, 2-deoxy-2, 3-d
Topics: Flavobacterium; Glycoside Hydrolases; Hydrolysis; Kinetics; Magnetic Resonance Spectroscopy; N-Acetylneuraminic Acid; Neuraminidase; Protein Conformation; Sialic Acids; Structure-Activity Relationship; Sugar Acids | 1997 |
Effects of cell surface ganglioside sialidase inhibition on growth control and differentiation of human neuroblastoma cells.
Topics: Antigens, Differentiation; Antigens, Surface; Cell Differentiation; Cell Division; Gangliosides; Heparin; Heparitin Sulfate; Humans; N-Acetylneuraminic Acid; Neuraminidase; Neuroblastoma; Tumor Cells, Cultured | 1997 |
Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors.
Topics: Acetamides; Adsorption; Animals; Binding Sites; Birds; Cell Line; Conserved Sequence; Dogs; Drug Resistance, Microbial; Enzyme Inhibitors; Guanidines; Heating; Hemagglutinin Glycoproteins, Influenza Virus; Humans; Influenza A virus; Kinetics; Molecular Structure; Mutation; N-Acetylneuraminic Acid; Neuraminidase; Oseltamivir; Phenotype; Pyrans; Sialic Acids; Substrate Specificity; Viral Plaque Assay; Virus Replication; Zanamivir | 1998 |
Role of neuraminidase in influenza virus-induced apoptosis.
Topics: alpha-Fetoproteins; Amantadine; Amino Acid Sequence; Ammonium Chloride; Animals; Antiviral Agents; Apoptosis; Base Sequence; Cell Line; DNA, Viral; Dogs; Enzyme Inhibitors; Guanidines; Humans; Influenza A virus; Molecular Sequence Data; N-Acetylneuraminic Acid; Neuraminidase; Pyrans; Sialic Acids; Substrate Specificity; Time Factors; Ultraviolet Rays; Zanamivir | 1999 |
Sequential deglycosylation and utilization of the N-linked, complex-type glycans of human alpha1-acid glycoprotein mediates growth of Streptococcus oralis.
Topics: Carbohydrate Sequence; Chromatography, Ion Exchange; Enzyme Inhibitors; Glycoside Hydrolases; Glycosylation; Humans; In Vitro Techniques; Molecular Sequence Data; Monosaccharides; N-Acetylneuraminic Acid; Neuraminidase; Orosomucoid; Polysaccharides; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Streptococcus oralis | 1999 |
Synthesis of a Neu2en5Ac analog hapten and isolation of monoclonal antibody to Neu2en5Ac.
Topics: Animals; Antibodies, Monoclonal; Carbohydrate Sequence; Dose-Response Relationship, Drug; Dose-Response Relationship, Immunologic; Haptens; Humans; Hybridomas; Magnetic Resonance Spectroscopy; Mice; Molecular Sequence Data; N-Acetylneuraminic Acid; Spleen | 1999 |
Synthesis of delta4-beta-D-glucopyranosiduronic acids as mimetics of 2,3-unsaturated sialic acids for sialidase inhibition.
Topics: Animals; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glucuronates; Influenza A virus; Molecular Mimicry; N-Acetylneuraminic Acid; Neuraminidase; Ostreidae; Salmonella typhimurium; Sialic Acids; Structure-Activity Relationship; Vibrio cholerae | 1999 |
The use of a quantitative fusion assay to evaluate HN-receptor interaction for human parainfluenza virus type 3.
Topics: Animals; Antibodies, Viral; Cell Fusion; Cell Line; Chlorocebus aethiops; Enzyme Inhibitors; HeLa Cells; Hemadsorption; Humans; N-Acetylneuraminic Acid; Neuraminidase; Parainfluenza Virus 3, Human; Receptors, Cell Surface; Receptors, Virus; Recombinant Fusion Proteins; Viral Plaque Assay | 1999 |
Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme.
Topics: Amino Acid Sequence; Binding Sites; Catalysis; Conserved Sequence; Crystallization; Crystallography, X-Ray; Enzyme Inhibitors; Haemophilus influenzae; Hydrogen Bonding; Models, Chemical; Models, Molecular; Molecular Sequence Data; N-Acetylneuraminic Acid; Oxo-Acid-Lyases; Protein Conformation; Sequence Alignment; Static Electricity; Structure-Activity Relationship; Sugar Alcohols; Tyrosine | 2000 |
Crystal structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase.
Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; HN Protein; Hydrogen-Ion Concentration; Hydrolysis; Lactose; Ligands; Models, Molecular; Molecular Sequence Data; Multienzyme Complexes; Mutation; N-Acetylneuraminic Acid; Newcastle disease virus; Protein Structure, Quaternary; Receptors, Virus; Sequence Alignment; Sialic Acids; Structure-Activity Relationship | 2000 |
Synthesis of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid analogues modified at the C-4 and C-9 positions and their behaviour towards sialidase from influenza virus and pig liver membrane.
Topics: Animals; Cell Membrane; Enzyme Inhibitors; Liver; N-Acetylneuraminic Acid; Neuraminidase; Orthomyxoviridae; Structure-Activity Relationship; Swine | 2001 |
Decrease in cell surface sialic acid in etoposide-treated Jurkat cells and the role of cell surface sialidase.
Topics: Apoptosis; Blotting, Northern; Cell Membrane; Enzyme Inhibitors; Etoposide; Flow Cytometry; Galactose; Humans; Jurkat Cells; N-Acetylneuraminic Acid; Neuraminidase; Sialic Acids; Sialyltransferases; Topoisomerase II Inhibitors | 2000 |
Analysis of inhibitor binding in influenza virus neuraminidase.
Topics: Antiviral Agents; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Models, Molecular; N-Acetylneuraminic Acid; Neuraminidase; Numerical Analysis, Computer-Assisted; Orthomyxoviridae; Sialic Acids; Solvents; Static Electricity | 2001 |
Thermal stability of the hemagglutinin-neuraminidase from Sendai virus evidences two folding domains.
Topics: Calorimetry; Enzyme Stability; Fluorescence; HN Protein; N-Acetylneuraminic Acid; Peptide Hydrolases; Protein Denaturation; Protein Folding; Protein Structure, Tertiary; Respirovirus; Temperature; Thermodynamics | 2001 |
Computational 3-D modeling and site-directed mutation of an antibody that binds Neu2en5Ac, a transition state analogue of a sialic acid.
Topics: Amino Acid Substitution; Antibodies; Antibodies, Catalytic; Base Sequence; Epitopes; Immunoglobulin Variable Region; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Acetylneuraminic Acid; Neuraminidase; Sequence Analysis, DNA | 2001 |
Inhibition of human parainfluenza virus type 1 sialidase by analogs of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid.
Topics: Animals; Antiviral Agents; Haplorhini; Humans; Kinetics; Magnetic Resonance Spectroscopy; N-Acetylneuraminic Acid; Neuraminidase; Parainfluenza Virus 1, Human; Structure-Activity Relationship; Tumor Cells, Cultured | 2001 |
Synthesis and anti-influenza virus activity of 4-guanidino-7-substituted Neu5Ac2en derivatives.
Topics: Antiviral Agents; Enzyme Inhibitors; Guanidine; Influenza A virus; Influenza B virus; Inhibitory Concentration 50; N-Acetylneuraminic Acid; Neuraminidase; Structure-Activity Relationship; Viral Plaque Assay | 2002 |
Synthesis and anti-influenza evaluation of polyvalent sialidase inhibitors bearing 4-guanidino-Neu5Ac2en derivatives.
Topics: Animals; Antiviral Agents; Enzyme Inhibitors; Glutamic Acid; Glyceryl Ethers; Guanidine; Guanidines; Influenza A virus; Inhibitory Concentration 50; Mice; N-Acetylneuraminic Acid; Neuraminidase; Orthomyxoviridae Infections; Pyrans; Sialic Acids; Structure-Activity Relationship; Viral Plaque Assay; Zanamivir | 2002 |
Oxochromium(V) species formed with 2,3-dehydro-2-deoxy-N-acetylneuraminic or N-acetylneuraminic (sialic) acids: an in vitro model system of oxochromium(V) species potentially stabilized in the respiratory tract upon inhalation of carcinogenic chromium(VI)
Topics: Carcinogens, Environmental; Chromium; Electron Spin Resonance Spectroscopy; Glutathione; In Vitro Techniques; N-Acetylneuraminic Acid; Organometallic Compounds; Oxidation-Reduction; Oxygen; Respiratory System | 2003 |
Inhibition of influenza A virus sialidase activity by sulfatide.
Topics: Animals; Birds; Enzyme Inhibitors; Fluorometry; Horses; Humans; Hydrogen-Ion Concentration; Hymecromone; Influenza A virus; Inhibitory Concentration 50; Kinetics; Liposomes; N-Acetylneuraminic Acid; Neuraminidase; Sulfoglycosphingolipids; Swine | 2003 |
Saturation transfer difference (STD) 1H-NMR experiments and in silico docking experiments to probe the binding of N-acetylneuraminic acid and derivatives to Vibrio cholerae sialidase.
Topics: Acetamides; Bacterial Proteins; Binding Sites; Enzyme Inhibitors; Hydrophobic and Hydrophilic Interactions; Molecular Structure; N-Acetylneuraminic Acid; Neuraminidase; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Conformation; Solutions; Structure-Activity Relationship; Uronic Acids; Vibrio cholerae | 2004 |
Sialic acid recognition by Vibrio cholerae neuraminidase.
Topics: Binding Sites; Calcium; Carbohydrate Conformation; Carbohydrate Sequence; Catalysis; Cholera Toxin; Electrons; Escherichia coli; Hydrolysis; Ions; Kinetics; Lectins; Ligands; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Molecular Sequence Data; N-Acetylneuraminic Acid; Neuraminidase; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Vibrio cholerae | 2004 |
Localization of sialidase-positive cells expressing Mac-1 and immunoglobulin in the mouse thymus.
Topics: Animals; B-Lymphocytes; Cell Communication; Cell Lineage; Cell Membrane; Copper; Enzyme Inhibitors; Hydrogen-Ion Concentration; Immunoglobulins; Immunohistochemistry; Macrophage-1 Antigen; Mice; Mice, Inbred C3H; N-Acetylneuraminic Acid; Neuraminidase; Phosphates; Spleen; T-Lymphocytes; Thymus Gland; Time Factors | 2004 |
Structural analogs of sialic acid interfere with the binding of erythrocyte binding antigen-175 to glycophorin A, an interaction crucial for erythrocyte invasion by Plasmodium falciparum.
Topics: Animals; Antigens, Protozoan; Dimerization; Enzyme-Linked Immunosorbent Assay; Erythrocytes; Glycophorins; Humans; Malaria, Falciparum; N-Acetylneuraminic Acid; Plasmodium falciparum; Protozoan Proteins | 2004 |
Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition.
Topics: Animals; Catalytic Domain; Crystallography, X-Ray; Humans; Models, Molecular; Molecular Structure; N-Acetylneuraminic Acid; Neuraminidase; Protein Structure, Secondary; Static Electricity; Structure-Activity Relationship; Substrate Specificity | 2005 |
A sialidase mutant displaying trans-sialidase activity.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Crystallography, X-Ray; Enzyme Inhibitors; Glycoproteins; Glycosylation; Hydrolysis; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; N-Acetylneuraminic Acid; Neuraminidase; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Alignment; Trypanosoma | 2005 |
Directed evolution of D-sialic acid aldolase to L-3-deoxy-manno-2-octulosonic acid (L-KDO) aldolase.
Topics: Amino Acids; Binding Sites; Carbohydrate Sequence; Catalysis; Cell Membrane; Crystallography, X-Ray; Escherichia coli; Evolution, Molecular; Fructose-Bisphosphate Aldolase; Kinetics; Models, Chemical; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Mutagenesis; Mutation; N-Acetylneuraminic Acid; Oxo-Acid-Lyases; Peptides; Polymerase Chain Reaction; Protein Conformation; Protein Engineering; Protein Structure, Secondary; Substrate Specificity; Sugar Acids | 2005 |
Reduction in the adherence of Pseudomonas aeruginosa to human buccal epithelial cells with neuraminidase inhibition.
Topics: Animals; Bacterial Adhesion; Cats; Cattle; Cheek; Dogs; Enzyme Inhibitors; Epithelial Cells; Humans; N-Acetylneuraminic Acid; Neuraminidase; Pseudomonas aeruginosa; Pseudomonas Infections | 2005 |
Structural analysis of a designed inhibitor complexed with the hemagglutinin-neuraminidase of Newcastle disease virus.
Topics: Crystallography, X-Ray; Enzyme Inhibitors; HN Protein; Models, Molecular; N-Acetylneuraminic Acid; Neuraminidase; Newcastle disease virus; Protein Conformation | 2006 |
Insights from modeling the 3D structure of H5N1 influenza virus neuraminidase and its binding interactions with ligands.
Topics: Acetamides; Binding Sites; Computer Simulation; Enzyme Activation; Guanidines; Influenza A Virus, H5N1 Subtype; Models, Chemical; Models, Molecular; N-Acetylneuraminic Acid; Neuraminidase; Oseltamivir; Protein Binding; Protein Conformation; Pyrans; Sequence Analysis, Protein; Sialic Acids; Structure-Activity Relationship; Zanamivir | 2006 |
Preparation of a fluorous protecting group and its application to the chemoenzymatic synthesis of sialidase inhibitor.
Topics: Enzyme Inhibitors; Hexosamines; Molecular Structure; N-Acetylneuraminic Acid; Neuraminidase; Oxo-Acid-Lyases | 2006 |
2-Deoxy-2,3-didehydro-N-acetylneuraminic acid analogues structurally modified at the C-4 position: synthesis and biological evaluation as inhibitors of human parainfluenza virus type 1.
Topics: Antiviral Agents; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; N-Acetylneuraminic Acid; Neuraminidase; Parainfluenza Virus 1, Human; Respirovirus Infections; Structure-Activity Relationship | 2006 |
STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core.
Topics: Animals; Cells, Cultured; Chlorocebus aethiops; Computer Simulation; Disaccharides; Dose-Response Relationship, Drug; Magnetic Resonance Spectroscopy; Models, Biological; Models, Molecular; Molecular Conformation; N-Acetylneuraminic Acid; Protein Binding; RNA-Binding Proteins; Rotavirus; Sialic Acids; Structure-Activity Relationship; Viral Nonstructural Proteins | 2007 |
Role of sialidase in Mycoplasma alligatoris-induced pulmonary fibroblast apoptosis.
Topics: Alligators and Crocodiles; Animals; Apoptosis; Caspase 9; Enzyme Inhibitors; fas Receptor; Fibroblasts; Flow Cytometry; Hyaluronan Receptors; In Situ Nick-End Labeling; Mycoplasma; Mycoplasma Infections; N-Acetylneuraminic Acid; Neuraminidase; Respiratory Tract Diseases | 2007 |
Sialidase activity in Mycoplasma synoviae.
Topics: Hymecromone; Mycoplasma synoviae; N-Acetylneuraminic Acid; Neuraminidase; Time Factors | 2007 |
Investigation into an efficient synthesis of 2,3-dehydro-N-acetyl neuraminic acid leads to three decarboxylated sialic acid dimers.
Topics: Decarboxylation; Dimerization; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Chemical; Molecular Structure; N-Acetylneuraminic Acid; Neuraminic Acids; Sialic Acids | 2008 |
Photoaffinity labeling of sialidase with a biotin-conjugated phenylaminodiazirine derivative of 2,3-didehydro-2-deoxy-N-acetylneuraminic acid.
Topics: Animals; Biotin; Diazomethane; Electrophoresis, Polyacrylamide Gel; Female; Mass Spectrometry; N-Acetylneuraminic Acid; Neuraminidase; Ovary; Photoaffinity Labels; Spectroscopy, Fourier Transform Infrared; Starfish | 2008 |
Membrane type sialidase inhibits the megakaryocytic differentiation of human leukemia K562 cells.
Topics: Blotting, Northern; Blotting, Western; Cell Differentiation; Cell Membrane; Cell Shape; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; G(M3) Ganglioside; Gene Expression Regulation, Leukemic; Glucosyltransferases; Humans; Integrin alpha2; K562 Cells; Megakaryocytes; Models, Biological; Morpholines; N-Acetylneuraminic Acid; Neuraminidase; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; Sialyltransferases; Tetradecanoylphorbol Acetate; Transfection | 2008 |
2-Deoxy-2,3-didehydro-N-acetylneuraminic acid analogs structurally modified by thiocarbamoylalkyl groups at the C-4 position: Synthesis and biological evaluation as inhibitors of human parainfluenza virus type 1.
Topics: Antiviral Agents; Enzyme Inhibitors; Humans; N-Acetylneuraminic Acid; Neuraminidase; Parainfluenza Virus 1, Human; Structure-Activity Relationship; Thiocarbamates | 2008 |
Structure of the catalytic domain of Streptococcus pneumoniae sialidase NanA.
Topics: Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; N-Acetylneuraminic Acid; Neuraminidase; Protein Structure, Tertiary; Sialic Acids; Streptococcus pneumoniae; Virulence Factors | 2008 |
Crystal structure of the NanB sialidase from Streptococcus pneumoniae.
Topics: Amino Acid Sequence; Binding Sites; Carbohydrates; Conserved Sequence; Crystallography, X-Ray; Lectins; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; N-Acetylneuraminic Acid; Neuraminidase; Protein Structure, Tertiary; Sequence Alignment; Streptococcus pneumoniae; Substrate Specificity; Sulfonic Acids | 2008 |
Sialic acid: a preventable signal for pneumococcal biofilm formation, colonization, and invasion of the host.
Topics: Animals; Biofilms; DNA Primers; Gene Expression Regulation, Bacterial; Humans; Mice; N-Acetylneuraminic Acid; Neuraminidase; Pneumococcal Infections; Saliva; Streptococcus pneumoniae; Zanamivir | 2009 |
Efficient method for the preparation of peracetylated Neu5Ac2en by flash vacuum pyrolysis.
Topics: Acetylation; Antiviral Agents; Enzyme Inhibitors; Heating; Methods; N-Acetylneuraminic Acid; Neuraminidase; Organic Chemistry Phenomena; Vacuum; Zanamivir | 2009 |
The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion.
Topics: Animals; Blood-Brain Barrier; Cell Adhesion; DNA Primers; Endothelial Cells; Humans; Male; Meningitis, Bacterial; Mice; Mice, Inbred BALB C; N-Acetylneuraminic Acid; Neuraminidase; Plasmids; Streptococcus pneumoniae | 2009 |
The effect of neuraminidase blocker on gabazine-induced seizures in rat hippocampus.
Topics: Action Potentials; Animals; CA1 Region, Hippocampal; Enzyme Inhibitors; GABA Antagonists; In Vitro Techniques; N-Acetylneuraminic Acid; Neuraminidase; Pyridazines; Rats; Rats, Wistar; Seizures | 2010 |
Blockade of endogenous neuraminidase leads to an increase of neuronal excitability and activity-dependent synaptogenesis in the rat hippocampus.
Topics: Animals; Calcium; Electrophysiology; Hippocampus; N-Acetylneuraminic Acid; Neuraminic Acids; Neuraminidase; Neurons; Rats; Rats, Wistar; Synapses; Tissue Culture Techniques | 2010 |
A single amino acid mutation at position 170 of human parainfluenza virus type 1 fusion glycoprotein induces obvious syncytium formation and caspase-3-dependent cell death.
Topics: Amino Acid Sequence; Animals; Caspase 3; Cell Death; Cell Line; Cell Transformation, Viral; Giant Cells; HN Protein; Humans; Kinetics; Macaca mulatta; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; N-Acetylneuraminic Acid; Neuraminidase; Parainfluenza Virus 1, Human; Protein Binding; Viral Fusion Proteins; Virus Replication | 2011 |
Syntheses of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid analogues modified by N-sulfonylamidino groups at the C-4 position and biological evaluation as inhibitors of human parainfluenza virus type 1.
Topics: Antiviral Agents; Humans; N-Acetylneuraminic Acid; Neuraminidase; Parainfluenza Virus 1, Human; Structure-Activity Relationship | 2011 |
Receptor-binding specificity of the human parainfluenza virus type 1 hemagglutinin-neuraminidase glycoprotein.
Topics: Azides; Binding Sites; Enzyme Inhibitors; Hexuronic Acids; HN Protein; Humans; Mutation; N-Acetylneuraminic Acid; Neuraminidase; Oligosaccharides; Parainfluenza Virus 1, Human; Protein Binding; Receptors, Cell Surface; Sialyl Lewis X Antigen | 2012 |
Real time enzyme inhibition assays provide insights into differences in binding of neuraminidase inhibitors to wild type and mutant influenza viruses.
Topics: Acids, Carbocyclic; Binding, Competitive; Cyclopentanes; Enzyme Assays; Enzyme Inhibitors; Guanidines; Humans; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza A Virus, H5N1 Subtype; Inhibitory Concentration 50; Kinetics; Mutation; N-Acetylneuraminic Acid; Neuraminidase; Orthomyxoviridae; Oseltamivir; Protein Binding; Substrate Specificity; Time Factors; Viral Proteins; Zanamivir | 2011 |
NEU1 and NEU3 sialidase activity expressed in human lung microvascular endothelia: NEU1 restrains endothelial cell migration, whereas NEU3 does not.
Topics: Aorta; Carotid Arteries; Cell Line; Cell Membrane; Cell Movement; Cell Nucleus; Cerebral Arteries; Cytosol; Endothelial Cells; Flow Cytometry; Gene Expression Regulation, Enzymologic; Humans; Hymecromone; Immunoblotting; Kidney; Lung; Microscopy, Confocal; N-Acetylneuraminic Acid; Neuraminidase; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Substrate Specificity | 2012 |
Molecular modeling of T. rangeli, T. brucei gambiense, and T. evansi sialidases in complex with the DANA inhibitor.
Topics: Amino Acid Sequence; Binding Sites; Enzyme Inhibitors; Molecular Dynamics Simulation; Molecular Sequence Data; N-Acetylneuraminic Acid; Neuraminidase; Protein Structure, Tertiary; Quantum Theory; Trypanosoma; Trypanosoma brucei brucei; Trypanosoma cruzi | 2012 |
Synthesis and evaluation of novel 3-C-alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility.
Topics: Alkylation; Catalytic Domain; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Influenza A virus; Models, Molecular; Molecular Structure; N-Acetylneuraminic Acid; Neuraminidase; Pliability; Structure-Activity Relationship | 2012 |
Exacerbation of influenza virus infections in mice by intranasal treatments and implications for evaluation of antiviral drugs.
Topics: Administration, Intranasal; Animals; Antiviral Agents; Dose-Response Relationship, Drug; Female; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Lung; Mice; Mice, Inbred BALB C; N-Acetylneuraminic Acid; Virus Replication; Zanamivir | 2012 |
X-aptamers: a bead-based selection method for random incorporation of druglike moieties onto next-generation aptamers for enhanced binding.
Topics: Aptamers, Nucleotide; Base Sequence; Hyaluronan Receptors; Ligands; N-Acetylneuraminic Acid; Protein Binding; SELEX Aptamer Technique | 2012 |
Ornithobacterium rhinotracheale has neuraminidase activity causing desialylation of chicken and turkey serum and tracheal mucus glycoproteins.
Topics: Animals; Blood Proteins; Chickens; Flavobacteriaceae Infections; Glycated Serum Proteins; Glycoproteins; Hungary; Immunoglobulin G; Mucus; N-Acetylneuraminic Acid; Neuraminidase; Ornithobacterium; Poultry Diseases; Trachea; Transferrin; Turkeys | 2013 |
Syntheses of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid analogues modified by α-acylaminoamido groups at the C-4 position using isocyanide-based four-component coupling and biological evaluation as inhibitors of human parainfluenza virus type 1.
Topics: Antiviral Agents; Humans; N-Acetylneuraminic Acid; Neuraminidase; Parainfluenza Virus 1, Human; Respirovirus Infections; Structure-Activity Relationship | 2013 |
Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues.
Topics: Enzyme Inhibitors; Humans; Isoenzymes; Magnetic Resonance Spectroscopy; Models, Molecular; N-Acetylneuraminic Acid; Neuraminidase; Spectrometry, Mass, Electrospray Ionization | 2013 |
Structural and biochemical characterization of the broad substrate specificity of Bacteroides thetaiotaomicron commensal sialidase.
Topics: Amino Acid Sequence; Bacteroides; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Humans; Hydrolysis; Kinetics; Models, Molecular; Molecular Sequence Data; N-Acetylneuraminic Acid; Neuraminidase; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Substrate Specificity; Sulfonic Acids | 2013 |
Novel 3,4-disubstituted-Neu5Ac2en derivatives as probes to investigate flexibility of the influenza virus sialidase 150-loop.
Topics: Molecular Probes; N-Acetylneuraminic Acid; Neuraminidase; Orthomyxoviridae; Protein Binding; Protein Structure, Secondary; Sialic Acids | 2013 |
Elastin-derived peptides are new regulators of insulin resistance development in mice.
Topics: Animals; Elastin; Energy Metabolism; Hyperglycemia; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; N-Acetylneuraminic Acid; Neuraminidase; Oligopeptides; Peptide Fragments; Receptor, Insulin; Receptors, Cell Surface | 2013 |
Access to 3-O-Functionalized N-Acetylneuraminic Acid Scaffolds.
Topics: Glycosides; Magnetic Resonance Spectroscopy; N-Acetylneuraminic Acid; Sialic Acids; Stereoisomerism; Structure-Activity Relationship | 2015 |
Role of Sialidase in Long-Term Potentiation at Mossy Fiber-CA3 Synapses and Hippocampus-Dependent Spatial Memory.
Topics: Animals; Hippocampus; Isoenzymes; Long-Term Potentiation; Male; Maze Learning; N-Acetylneuraminic Acid; Neuraminidase; Rats; Rats, Wistar; RNA Interference; RNA, Small Interfering; Spatial Memory; Synapses | 2016 |
Naringenin suppresses Edwardsiella tarda infection in GAKS cells by NanA sialidase inhibition.
Topics: Animals; Cells, Cultured; Citrus; Edwardsiella tarda; Enterobacteriaceae Infections; Enzyme Inhibitors; Fish Diseases; Flavanones; Goldfish; N-Acetylneuraminic Acid; Neuraminidase | 2017 |
[Effects of Sialidase Inhibitor on Proliferation and Apoptosis of Endometrial Cancer Cells].
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Endometrial Neoplasms; Female; Humans; Matrix Metalloproteinases; N-Acetylneuraminic Acid; Neuraminidase; Proliferating Cell Nuclear Antigen | 2016 |
Customizable de novo design strategies for DOCK: Application to HIVgp41 and other therapeutic targets.
Topics: Databases, Chemical; Drug Design; HIV Envelope Protein gp41; Ligands; Molecular Docking Simulation; N-Acetylneuraminic Acid; Protein Binding; Protein Conformation | 2017 |
A tetravalent sialic acid-coated tetraphenylethene luminogen with aggregation-induced emission characteristics: design, synthesis and application for sialidase activity assay, high-throughput screening of sialidase inhibitors and diagnosis of bacterial va
Topics: Adult; Clostridium perfringens; Enzyme Inhibitors; Female; Fluorescence; Fluorescent Dyes; Fluorometry; High-Throughput Screening Assays; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Limit of Detection; Middle Aged; N-Acetylneuraminic Acid; Neuraminidase; Oseltamivir; Sialic Acids; Stilbenes; Vaginosis, Bacterial; Vibrio cholerae; Young Adult; Zanamivir | 2018 |
Catalytic mechanism of type C sialidase from Streptococcus pneumoniae: from covalent intermediate to final product.
Topics: Bacterial Proteins; Biocatalysis; Computational Biology; Molecular Dynamics Simulation; N-Acetylneuraminic Acid; Neuraminidase; Protein Conformation; Streptococcus pneumoniae | 2018 |
Identification and characterization of a novel, versatile sialidase from a Sphingobacterium that can hydrolyze the glycosides of any sialic acid species at neutral pH.
Topics: Amino Acid Motifs; Animals; Bacterial Proteins; CHO Cells; Cricetulus; Glycosides; Hydrogen-Ion Concentration; Hydrolysis; N-Acetylneuraminic Acid; Neuraminic Acids; Neuraminidase; Sialic Acids; Sphingobacterium; Substrate Specificity; Temperature | 2020 |
The sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetylneuraminic acid is a glucose-dependent potentiator of insulin secretion.
Topics: Animals; Benzothiazoles; Calcium Signaling; Coloring Agents; Drug Evaluation, Preclinical; Fasting; Glucose; Glucose Tolerance Test; Hypoglycemic Agents; Injections, Intravenous; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; N-Acetylneuraminic Acid; Neuraminidase; Sialic Acids | 2020 |
Therapeutic Effect of Neuraminidase-1-Selective Inhibition in Mouse Models of Bleomycin-Induced Pulmonary Inflammation and Fibrosis.
Topics: Animals; Bleomycin; Cells, Cultured; Enzyme Inhibitors; Female; Fibroblasts; Humans; Mice; Mice, Inbred C57BL; Mucin-1; N-Acetylneuraminic Acid; Neuraminidase; Pneumonia; Pulmonary Fibrosis | 2021 |
A CD209 ligand and a sialidase inhibitor differentially modulate adipose tissue and liver macrophage populations and steatosis in mice on the Methionine and Choline-Deficient (MCD) diet.
Topics: Adipose Tissue; Animals; Cell Adhesion Molecules; Choline Deficiency; Diabetes Mellitus, Type 2; Disease Models, Animal; Fatty Liver; Inflammation; Lectins, C-Type; Liver; Macrophages; Mice; N-Acetylneuraminic Acid; Neuraminidase; Non-alcoholic Fatty Liver Disease; Receptors, Cell Surface | 2020 |