Page last updated: 2024-08-25

n-acetylglutamic acid and urea

n-acetylglutamic acid has been researched along with urea in 53 studies

Research

Studies (53)

TimeframeStudies, this research(%)All Research%
pre-199026 (49.06)18.7374
1990's12 (22.64)18.2507
2000's10 (18.87)29.6817
2010's5 (9.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hayase, K; Yonekawa, G; Yoshida, A2
Brini, CM; Cyr, DM; Egan, SG; Tremblay, GC1
Felipo, V; Grisolía, S; Miñana, MD2
Barber, T; García de la Asunción, J; Puertes, IR; Viña, JR1
Cabo, J; Jimenez-Nacher, I; Jorda, A; Marti, J; Portoles, M1
Lund, P; Wiggins, D2
Bourdel, G; Champigny, O; Hitier, Y1
Alonso, E; Aniento, F; Cabo, JR; Garcia-España, A; Portolés, M1
Costell, M; Grisolía, S; O'Connor, JE1
Zollner, H2
Anderson, PM1
Stewart, PM; Walser, M2
Costell, M; Grisolía, S; Míguez, MP; O'Connor, JE1
Coude, FX; Grimber, G; Parvy, P; Petit, F; Rabier, D1
Meijer, AJ; Verhoeven, AJ1
Coude, FX; Grimber, G; Parvy, P; Rabier, D1
Coude, FX; Grimber, G1
Cathelineau, L; Coudé, FX; Grimber, G; Kamoun, P; Parvy, P; Rabier, D1
Cabo, J; Gomez, M; Grisolía, S; Jordá, A1
Bibb, PC; Kadowaki, H; Knox, WE1
Cohen, PP1
Colombo, JP1
Kawamoto, S; Mori, M; Sonoda, T; Tatibana, M1
Cathelineau, L; Coudé, FX; Rabier, D1
Fujinami, S; Hosoya, M; Katsunuma, T; Saheki, T1
Hayase, K; Yoshida, A2
Beliveau Carey, G; Brusilow, S; Cheung, CW; Cohen, NS; Raijman, L1
Brosnan, JT; Nissim, I; Yudkoff, M1
Anderson, PM; Julsrud, EA; Walsh, PJ1
Hayase, K; Koie, M; Naganuma, Y; Yoshida, A1
Brosnan, JT; Brosnan, ME; Nissim, I; Yudkoff, M1
Bush, JA; Davis, TA; Nguyen, HV; Suryawan, A; Wu, G1
Daikhin, Y; Horyn, O; Lazarow, A; Nissim, I; Yudkoff, M1
Hayase, K; Hirano, E; Lyou, S; Sano, A; Tujioka, K; Yokogoshi, H; Yoshida, A1
Horiuchi, M; Jalil, A; Kobayashi, K; Li, XX; Saheki, T; Yoshida, G1
Daikhin, Y; Horyn, O; Lazarow, A; Luhovyy, B; Nissim, I; Yudkoff, M1
Caldovic, L; Lopez, GY; Morizono, H; Panglao, MG; Shi, D; Summar, ML; Tuchman, M1
Fukaya, Y; Hayase, K; Sano, A; Tujioka, K; Yokogoshi, H1
Burton, B; Caldovic, L; Daikhin, Y; Horyn, O; Korson, M; Nissim, I; Tuchman, M; Yudkoff, M1
Barcelona, B; Bendala, E; Cervera, J; Gallego, J; Martínez, AI; Pekkala, S; Rubio, V; Yefimenko, I1
Hayase, K; Ohsumi, M; Shi, X; Tuchiya, T; Tujioka, K; Yokogoshi, H1
Aires, CC; de Almeida, IT; Duran, M; Ijlst, L; Silva, MF; van Cruchten, A; Wanders, RJ1
Hayase, K; Ohsumi, M; Tujioka, K; Yokogoshi, H1
Barcelona, B; Caldovic, L; Cervera, J; Daikhin, Y; Horyn, O; Nissim, I; Tuchman, M; Yudkoff, M1
Cervera, J; Díez-Fernández, C; Gallego, J; Häberle, J; Rubio, V1
Cervera, J; de Cima, S; Díez-Fernández, C; Fita, I; Martínez, AI; Polo, LM; Rubio, V1

Reviews

2 review(s) available for n-acetylglutamic acid and urea

ArticleYear
The ornithine-urea cycle: biosynthesis and regulation of carbamyl phosphate synthetase I and ornithine transcarbamylase.
    Current topics in cellular regulation, 1981, Volume: 18

    Topics: Ammonia; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Citrulline; Dietary Proteins; Glutamates; Kinetics; Ligases; Mitochondria, Liver; Ornithine; Ornithine Carbamoyltransferase; Urea

1981
Some regulatory aspects of urea synthesis.
    Enzyme, 1981, Volume: 26, Issue:5

    Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; Carbamyl Phosphate; Citric Acid Cycle; Dietary Proteins; Female; Glutamates; Humans; Male; Ornithine; Proteins; Urea

1981

Trials

1 trial(s) available for n-acetylglutamic acid and urea

ArticleYear
N-carbamylglutamate markedly enhances ureagenesis in N-acetylglutamate deficiency and propionic acidemia as measured by isotopic incorporation and blood biomarkers.
    Pediatric research, 2008, Volume: 64, Issue:2

    Topics: Acetyl Coenzyme A; Adult; Amino Acids; Ammonia; Biomarkers; Carbon Dioxide; Carbon Isotopes; Child; Feasibility Studies; Female; Glutamates; Humans; Male; Metabolic Diseases; Middle Aged; Propionates; Urea

2008

Other Studies

50 other study(ies) available for n-acetylglutamic acid and urea

ArticleYear
Changes in liver concentration of N-acetylglutamate and ornithine are involved in regulating urea synthesis in rats treated with thyroid hormone.
    The Journal of nutrition, 1992, Volume: 122, Issue:5

    Topics: Animals; Body Weight; Glutamates; Liver; Male; Organ Size; Ornithine; Ornithine Decarboxylase; Ornithine-Oxo-Acid Transaminase; Rats; Rats, Inbred Strains; Thyroid Hormones; Urea

1992
On the mechanism of inhibition of gluconeogenesis and ureagenesis by sodium benzoate.
    Biochemical pharmacology, 1991, Jul-15, Volume: 42, Issue:3

    Topics: Acetyl Coenzyme A; Adenine Nucleotides; Animals; Aspartic Acid; Benzoates; Benzoic Acid; Bicarbonates; Carbamoyl-Phosphate Synthase (Ammonia); Cells, Cultured; Enzyme Activation; Gluconeogenesis; Glutamates; Glutamic Acid; Kinetics; Liver; Male; Mitochondria, Liver; Orotic Acid; Pyruvate Carboxylase; Rats; Sodium; Sodium Bicarbonate; Urea

1991
Control of urea synthesis and ammonia utilization in protein deprivation and refeeding.
    Archives of biochemistry and biophysics, 1991, Volume: 285, Issue:2

    Topics: Ammonia; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Dietary Proteins; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Liver; Male; Protein Deficiency; Rats; Rats, Inbred Strains; Urea

1991
Amino acid metabolism and protein synthesis in lactating rats fed on a liquid diet.
    The Biochemical journal, 1990, Aug-15, Volume: 270, Issue:1

    Topics: Amino Acids; Animals; Biological Transport; Body Weight; Dietary Proteins; Eating; Glutamates; Jejunum; Lactation; Liver; Mammary Glands, Animal; Muscles; Nitrogen; Protein Biosynthesis; Rats; Rats, Inbred Strains; Urea

1990
Effect of thyroid hormones on urea biosynthesis and related processes in rat liver.
    Endocrinology, 1988, Volume: 123, Issue:5

    Topics: Amino Acids; Ammonia; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Cyclic AMP; Glucagon; Glutamates; Hyperthyroidism; Hypothyroidism; Iodide Peroxidase; Liver; Male; Ornithine Carbamoyltransferase; Rats; Rats, Inbred Strains; Thyroid Hormones; Thyroxine; Triiodothyronine; Urea

1988
The ornithine requirement of urea synthesis. Formation of ornithine from glutamine in hepatocytes.
    The Biochemical journal, 1986, Nov-01, Volume: 239, Issue:3

    Topics: Ammonium Chloride; Animals; Bucladesine; Female; Glutamates; Glutamine; In Vitro Techniques; Liver; Ornithine; Rats; Rats, Inbred Strains; Urea

1986
Urea concentration and ornithine decarboxylase in liver of female rats.
    The American journal of physiology, 1986, Volume: 250, Issue:4 Pt 1

    Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Eflornithine; Female; Glutamates; Kinetics; Liver; Ornithine; Ornithine Decarboxylase; Pregnancy; Rats; Rats, Inbred Strains; Thioacetamide; Urea

1986
Long-term ingestion of ammonium increases acetylglutamate and urea levels without affecting the amount of carbamoyl-phosphate synthase.
    European journal of biochemistry, 1988, Oct-01, Volume: 176, Issue:3

    Topics: Acetyltransferases; Amino-Acid N-Acetyltransferase; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Diet; Dietary Proteins; Glutamates; Male; Mitochondria, Liver; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Time Factors; Urea

1988
Effects of inhibition of ornithine aminotransferase or of general aminotransferases on urea and citrulline synthesis and on the levels of acetylglutamate in isolated rat hepatocytes.
    Molecular and cellular biochemistry, 1988, Volume: 79, Issue:2

    Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Citrulline; Cyclohexanecarboxylic Acids; Glutamates; Liver; Male; Ornithine-Oxo-Acid Transaminase; Rats; Rats, Inbred Strains; Transaminases; Urea

1988
The potentiation of ammonia toxicity by sodium benzoate is prevented by L-carnitine.
    Biochemical and biophysical research communications, 1987, Jun-15, Volume: 145, Issue:2

    Topics: Ammonia; Animals; Benzoates; Benzoic Acid; Carnitine; Drug Synergism; Glutamates; Male; Mice; Mitochondria, Liver; Urea

1987
Regulation of the n-acetylglutamate content of rat hepatocytes by the glutamate concentration.
    Advances in experimental medicine and biology, 1982, Volume: 153

    Topics: Ammonia; Animals; Aspartic Acid; Citrulline; Diet; Glutamates; Glutamic Acid; Liver; Ornithine; Rats; Urea

1982
Glutamine- and N-acetylglutamate-dependent carbamoyl phosphate synthetase in elasmobranchs.
    Science (New York, N.Y.), 1980, Apr-18, Volume: 208, Issue:4441

    Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Fishes; Glutamates; Liver; Phosphotransferases; Species Specificity; Urea

1980
Short term regulation of ureagenesis.
    The Journal of biological chemistry, 1980, Jun-10, Volume: 255, Issue:11

    Topics: Acetyltransferases; Amino Acids; Amino-Acid N-Acetyltransferase; Animals; Arginine; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Female; Glutamates; Kinetics; Liver; Mitochondria, Liver; Ornithine; Phosphotransferases; Rats; Urea

1980
Effects of L-carnitine on urea synthesis following acute ammonia intoxication in mice.
    Biochemical and biophysical research communications, 1984, May-16, Volume: 120, Issue:3

    Topics: Ammonia; Animals; Bicarbonates; Carnitine; Glutamates; Male; Mice; Mitochondria, Liver; Sodium Bicarbonate; Urea

1984
Inhibition of ureagenesis by valproate in rat hepatocytes. Role of N-acetylglutamate and acetyl-CoA.
    The Biochemical journal, 1983, Oct-15, Volume: 216, Issue:1

    Topics: Acetyl Coenzyme A; Animals; Glutamates; In Vitro Techniques; Liver; Male; Rats; Rats, Inbred Strains; Urea; Valproic Acid

1983
N-acetylglutamate and urea synthesis.
    The Biochemical journal, 1984, Oct-15, Volume: 223, Issue:2

    Topics: Glutamates; Urea

1984
Role of N-acetylglutamate and acetyl-CoA in the inhibition of ureagenesis by isovaleric acid in isolated rat hepatocytes.
    Biochimica et biophysica acta, 1983, Nov-22, Volume: 761, Issue:1

    Topics: Acetyl Coenzyme A; Alanine; Animals; Glutamates; Hemiterpenes; In Vitro Techniques; Liver; Male; Ornithine; Pentanoic Acids; Rats; Rats, Inbred Strains; Urea; Valerates

1983
Inhibition of urea synthesis by pent-4-enoic acid: potentiation by ammonia.
    Biochemical and biophysical research communications, 1984, Jan-13, Volume: 118, Issue:1

    Topics: Ammonium Chloride; Animals; Citrulline; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Glutamates; In Vitro Techniques; Kinetics; Liver; Male; Rats; Rats, Inbred Strains; Urea

1984
Is N-acetylglutamate a short-term regulator of urea synthesis?
    The Biochemical journal, 1984, Mar-15, Volume: 218, Issue:3

    Topics: Animals; Female; Glutamates; Glutamine; In Vitro Techniques; Liver; Methods; Rats; Rats, Inbred Strains; Urea

1984
A mechanism for valproate-induced hyperammonemia.
    Advances in experimental medicine and biology, 1982, Volume: 153

    Topics: Ammonia; Animals; Citrulline; Glutamates; Male; Mitochondria, Liver; Oxidation-Reduction; Rats; Rats, Inbred Strains; Urea; Valproic Acid

1982
Effect of starvation on the N-acetylglutamate system of rat liver.
    FEBS letters, 1983, May-30, Volume: 156, Issue:1

    Topics: Acetyltransferases; Amidohydrolases; Amino-Acid N-Acetyltransferase; Animals; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cytosol; Glutamates; Liver; Male; Mitochondria, Liver; Ornithine Carbamoyltransferase; Rats; Rats, Inbred Strains; Starvation; Urea

1983
Capacity of cyclic urea synthesis in neonatal rat liver.
    Biology of the neonate, 1983, Volume: 44, Issue:1

    Topics: Age Factors; Ammonium Chloride; Animals; Animals, Newborn; Argininosuccinate Synthase; Aspartic Acid; Female; Fetus; Glutamates; In Vitro Techniques; Kinetics; Liver; Male; Ornithine; Rats; Rats, Inbred Strains; Urea

1983
Enzyme regulation of n-acetylglutamate synthesis in mouse and rat liver.
    Advances in experimental medicine and biology, 1982, Volume: 153

    Topics: Acetyltransferases; Amino-Acid N-Acetyltransferase; Animals; Arginine; Cycloheximide; Diet; Eating; Enzyme Activation; Fasting; Glutamates; Liver; Mice; Mitochondria, Liver; Rats; Rats, Inbred Strains; Urea

1982
Acute glucagon treatment in rats fed various protein diets effect on n-acetyl glutamate concentration.
    Advances in experimental medicine and biology, 1982, Volume: 153

    Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Citrulline; Dietary Proteins; Enzyme Activation; Glucagon; Glutamates; Mitochondria, Liver; Rats; Rats, Inbred Strains; Urea

1982
Regulation of urea synthesis: changes in the concentration of ornithine in the liver corresponding to changes in urea synthesis.
    Advances in experimental medicine and biology, 1982, Volume: 153

    Topics: Ammonium Chloride; Animals; Arginine; Citrulline; Dietary Proteins; Glutamates; Liver; Male; Ornithine; Rats; Rats, Inbred Strains; Stimulation, Chemical; Urea

1982
Regulation of urea synthesis. The effect of ammonia on the N-acetylglutamate content of isolated rat liver cells.
    Biochimica et biophysica acta, 1981, Aug-17, Volume: 676, Issue:2

    Topics: Ammonium Chloride; Animals; Dietary Carbohydrates; Glutamates; Kinetics; Liver; Male; Mitochondria, Liver; Ornithine; Rats; Starvation; Urea

1981
Short-term regulation of urea synthesis.
    Nutrition reviews, 1981, Volume: 39, Issue:5

    Topics: Amino Acids; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Female; Glucagon; Glutamates; Ligases; Liver; Rats; Urea

1981
Failure of the normal ureagenic response to amino acids in organic acid-loaded rats. Proposed mechanism for the hyperammonemia of propionic and methylmalonic acidemia.
    The Journal of clinical investigation, 1980, Volume: 66, Issue:3

    Topics: Acyl Coenzyme A; Adenosine Triphosphate; Ammonia; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Female; Glutamates; Kinetics; Liver; Malonates; Methylmalonic Acid; Ornithine Carbamoyltransferase; Propionates; Rats; Urea

1980
Role of ornithine in urea synthesis in rats treated with thyroid hormone.
    Bioscience, biotechnology, and biochemistry, 1995, Volume: 59, Issue:5

    Topics: Animals; Glutamates; Liver; Male; Ornithine; Propylthiouracil; Rats; Rats, Wistar; Triiodothyronine; Urea

1995
Arginine affects urea synthesis in rats treated with thyroid hormone.
    The Journal of nutrition, 1993, Volume: 123, Issue:2

    Topics: Animals; Arginine; Glutamates; Glutamic Acid; Liver; Male; Propylthiouracil; Rats; Rats, Wistar; Triiodothyronine; Urea

1993
Regulation of urea and citrulline synthesis under physiological conditions.
    The Biochemical journal, 1993, May-15, Volume: 292 ( Pt 1)

    Topics: Amino Acids; Ammonia; Animals; Citrulline; Glutamates; Male; Mitochondria, Liver; Nitrogen; Ornithine; Rats; Rats, Sprague-Dawley; Urea

1993
Regulation of [15N]urea synthesis from [5-15N]glutamine. Role of pH, hormones, and pyruvate.
    The Journal of biological chemistry, 1996, Dec-06, Volume: 271, Issue:49

    Topics: Amino Acids; Ammonia; Animals; Citric Acid Cycle; Citrulline; Gas Chromatography-Mass Spectrometry; Glucagon; Glutamates; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Insulin; Liver; Male; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Urea

1996
N-acetyl-L-glutamate and the urea cycle in gulf toadfish (Opsanus beta) and other fish.
    Archives of biochemistry and biophysics, 1998, Feb-01, Volume: 350, Issue:1

    Topics: Animals; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Dogfish; Fishes; Glutamates; Liver; Muscles; Species Specificity; Urea; Water-Electrolyte Balance

1998
Role of N-acetylglutamate turnover in urea synthesis by rats treated with the thyroid hormone.
    Bioscience, biotechnology, and biochemistry, 1998, Volume: 62, Issue:3

    Topics: Animals; Glutamates; Liver; Male; Propylthiouracil; Rats; Rats, Wistar; Thyroid Gland; Triiodothyronine; Urea

1998
Role of ornithine in the N-acetylglutamate turnover in the liver of rats.
    Bioscience, biotechnology, and biochemistry, 1999, Volume: 63, Issue:3

    Topics: Animals; Body Weight; Diet; Glutamates; Half-Life; Liver; Male; Organ Size; Ornithine; Rats; Rats, Wistar; Urea

1999
Studies of hepatic glutamine metabolism in the perfused rat liver with (15)N-labeled glutamine.
    The Journal of biological chemistry, 1999, Oct-08, Volume: 274, Issue:41

    Topics: Ammonia; Animals; Aspartic Acid; Carbamyl Phosphate; Citrulline; Glucagon; Glutamates; Glutaminase; Glutamine; Insulin; Liver; Male; Nitrogen Isotopes; Oxygen Consumption; Perfusion; Rats; Rats, Sprague-Dawley; Urea

1999
Somatotropin-induced amino acid conservation in pigs involves differential regulation of liver and gut urea cycle enzyme activity.
    The Journal of nutrition, 2002, Volume: 132, Issue:1

    Topics: Amino Acids; Ammonia; Animals; Bicarbonates; Blood Urea Nitrogen; Body Weight; Breath Tests; Carbamyl Phosphate; Carbon Isotopes; Female; Glutamates; Growth Hormone; Jejunum; Liver; Nitrogen; Oxidation-Reduction; Phenylalanine; Random Allocation; Substrate Specificity; Swine; Urea

2002
Regulation of urea synthesis by agmatine in the perfused liver: studies with 15N.
    American journal of physiology. Endocrinology and metabolism, 2002, Volume: 283, Issue:6

    Topics: Agmatine; Ammonium Chloride; Animals; Arginine; Cytosol; Dose-Response Relationship, Drug; Glutamates; Glutamine; In Vitro Techniques; Liver; Male; Mitochondria, Liver; Nitric Oxide; Nitric Oxide Donors; Nitrogen Isotopes; Oxygen Consumption; Perfusion; Rats; Rats, Sprague-Dawley; Urea

2002
Role of N-acetylglutamate concentration and ornithine transport into mitochondria in urea synthesis of rats given proteins of different quality.
    Journal of agricultural and food chemistry, 2002, Dec-04, Volume: 50, Issue:25

    Topics: Animals; Biological Transport; Caseins; Dietary Proteins; Egg Proteins; Glutamates; Glutens; Liver; Male; Mitochondria, Liver; Ornithine; Rats; Rats, Wistar; Urea

2002
Hyperammonemia in carnitine-deficient adult JVS mice used by starvation.
    Metabolic brain disease, 2002, Volume: 17, Issue:4

    Topics: Aging; Amino Acids; Ammonia; Animals; Animals, Newborn; Carbamoyl-Phosphate Synthase (Ammonia); Carnitine; Glutamates; Hyperammonemia; Liver; Mice; Mice, Mutant Strains; Starvation; Time Factors; Urea

2002
Role of the glutamate dehydrogenase reaction in furnishing aspartate nitrogen for urea synthesis: studies in perfused rat liver with 15N.
    The Biochemical journal, 2003, Nov-15, Volume: 376, Issue:Pt 1

    Topics: Amino Acids; Ammonia; Animals; Aspartic Acid; Constriction; Freezing; Glutamate Dehydrogenase; Glutamates; Glutamine; Liver; Male; Nitrogen; Nitrogen Isotopes; Perfusion; Rats; Rats, Sprague-Dawley; Urea

2003
Late onset N-acetylglutamate synthase deficiency caused by hypomorphic alleles.
    Human mutation, 2005, Volume: 25, Issue:3

    Topics: Adult; Age of Onset; Alleles; Amino Acid Sequence; Amino Acid Substitution; Amino-Acid N-Acetyltransferase; Animals; Brain Death; Catalysis; Child; Consensus Sequence; Dietary Proteins; DNA Mutational Analysis; Fatal Outcome; Female; Glutamates; Glutamic Acid; Humans; Hyperammonemia; Infant, Newborn; Learning Disabilities; Male; Molecular Sequence Data; Multiple Trauma; Mutagenesis, Site-Directed; Mutation, Missense; Point Mutation; Postoperative Complications; Recombinant Fusion Proteins; RNA Splice Sites; Substrate Specificity; Urea; Vertebrates

2005
Role of N-acetylglutamate turnover in urea synthesis of rats given proteins of different quality.
    Journal of nutritional science and vitaminology, 2005, Volume: 51, Issue:2

    Topics: Acetyltransferases; Amino-Acid N-Acetyltransferase; Animals; Caseins; Dietary Proteins; Egg Proteins; Glutamates; Glutamic Acid; Glutens; Kinetics; Liver; Male; Rats; Rats, Wistar; Urea

2005
Structural insight on the control of urea synthesis: identification of the binding site for N-acetyl-L-glutamate, the essential allosteric activator of mitochondrial carbamoyl phosphate synthetase.
    The Biochemical journal, 2009, Nov-11, Volume: 424, Issue:2

    Topics: Allosteric Regulation; Binding Sites; Carbon-Nitrogen Ligases; Crystallography, X-Ray; Glutamates; Humans; Mitochondria; Models, Molecular; Mutation; Protein Structure, Tertiary; Urea

2009
Changes in N-acetylglutamate are involved in regulating urea synthesis in rats given a low gluten diet supplemented with L-lysine, L-methinone and L-threonine.
    Journal of nutritional science and vitaminology, 2009, Volume: 55, Issue:5

    Topics: Amino Acids; Amino-Acid N-Acetyltransferase; Animals; Arginine; Diet, Gluten-Free; Dietary Supplements; Glutamates; Liver; Male; Rats; Rats, Wistar; Urea

2009
New insights on the mechanisms of valproate-induced hyperammonemia: inhibition of hepatic N-acetylglutamate synthase activity by valproyl-CoA.
    Journal of hepatology, 2011, Volume: 55, Issue:2

    Topics: Acyl Coenzyme A; Amino-Acid N-Acetyltransferase; Ammonia; Animals; Anticonvulsants; Citrulline; Disease Models, Animal; Glutamates; Glutamine; Humans; Hyperammonemia; In Vitro Techniques; Liver; Male; Mice; Mice, Inbred C57BL; Models, Biological; Rats; Rats, Wistar; Urea; Valproic Acid

2011
Effect of the quality of dietary amino acids composition on the urea synthesis in rats.
    Journal of nutritional science and vitaminology, 2011, Volume: 57, Issue:1

    Topics: Alanine; Amino Acids; Animals; Caseins; Dietary Proteins; Egg Proteins; Glutamates; Glutamic Acid; Glutens; Liver; Male; Methionine; Ornithine; Protein Biosynthesis; Rats; Rats, Wistar; Serine; Urea

2011
Down-regulation of hepatic urea synthesis by oxypurines: xanthine and uric acid inhibit N-acetylglutamate synthase.
    The Journal of biological chemistry, 2011, Jun-24, Volume: 286, Issue:25

    Topics: 1-Methyl-3-isobutylxanthine; Amino-Acid N-Acetyltransferase; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Citrulline; Dose-Response Relationship, Drug; Down-Regulation; Glutamates; Hepatocytes; Kinetics; Liver; Male; Mice; Mitochondria; Rats; Rats, Sprague-Dawley; Urea; Uric Acid; Xanthine

2011
The Study of Carbamoyl Phosphate Synthetase 1 Deficiency Sheds Light on the Mechanism for Switching On/Off the Urea Cycle.
    Journal of genetics and genomics = Yi chuan xue bao, 2015, May-20, Volume: 42, Issue:5

    Topics: Ammonia; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase I Deficiency Disease; Enzyme Stability; Glutamates; Humans; Kinetics; Molecular Dynamics Simulation; Mutation; Protein Structure, Tertiary; Signal Transduction; Urea

2015
Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis.
    Scientific reports, 2015, Nov-23, Volume: 5

    Topics: Amino Acid Motifs; Ammonia; Animals; Baculoviridae; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase I Deficiency Disease; Carbamyl Phosphate; Cloning, Molecular; Crystallography, X-Ray; Gene Expression; Glutamates; Humans; Models, Molecular; Molecular Sequence Data; Mutation; Phosphorylation; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Sf9 Cells; Spodoptera; Substrate Specificity; Urea

2015