Compounds > n-acetylglutamic acid
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n-acetylglutamic acid and ammonium hydroxide

n-acetylglutamic acid has been researched along with ammonium hydroxide in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199012 (46.15)18.7374
1990's7 (26.92)18.2507
2000's4 (15.38)29.6817
2010's3 (11.54)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lin, CY; Lin, SP; Seashore, MR; Tuchman, M; Vockley, CM; Vockley, J; Wu, TC1
Felipo, V; Grisolía, S; Miñana, MD1
Costell, M; Grisolía, S; O'Connor, JE2
Holzknecht, RA; Tuchman, M1
Cabo, J; Jimenez-Nacher, I; Jorda, A; Marti, J; Portoles, M1
Kobayashi, Y; Nishida, N; Sugimoto, T; Takeuchi, T1
Grisolía, S; Guerri, C; Jordá, A; O'Connor, JE1
Zollner, H1
Costell, M; Grisolía, S; Míguez, MP; O'Connor, JE1
Stewart, PM; Walser, M3
Cathelineau, L; Coudé, FX; Grimber, G; Kamoun, P; Parvy, P; Rabier, D1
Cohen, PP1
Colombo, JP1
Beliveau Carey, G; Brusilow, S; Cheung, CW; Cohen, NS; Raijman, L1
Brosnan, JT; Nissim, I; Yudkoff, M1
Brosnan, JT; Brosnan, ME; Nissim, I; Yudkoff, M1
Bush, JA; Davis, TA; Nguyen, HV; Suryawan, A; Wu, G1
Horiuchi, M; Jalil, A; Kobayashi, K; Li, XX; Saheki, T; Yoshida, G1
Daikhin, Y; Horyn, O; Lazarow, A; Luhovyy, B; Nissim, I; Yudkoff, M1
Burton, B; Caldovic, L; Daikhin, Y; Horyn, O; Korson, M; Nissim, I; Tuchman, M; Yudkoff, M1
Aires, CC; de Almeida, IT; Duran, M; Ijlst, L; Silva, MF; van Cruchten, A; Wanders, RJ1
Cervera, J; Díez-Fernández, C; Gallego, J; Häberle, J; Rubio, V1
Cervera, J; de Cima, S; Díez-Fernández, C; Fita, I; Martínez, AI; Polo, LM; Rubio, V1

Reviews

2 review(s) available for n-acetylglutamic acid and ammonium hydroxide

ArticleYear
The ornithine-urea cycle: biosynthesis and regulation of carbamyl phosphate synthetase I and ornithine transcarbamylase.
    Current topics in cellular regulation, 1981, Volume: 18

    Topics: Ammonia; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Citrulline; Dietary Proteins; Glutamates; Kinetics; Ligases; Mitochondria, Liver; Ornithine; Ornithine Carbamoyltransferase; Urea

1981
Some regulatory aspects of urea synthesis.
    Enzyme, 1981, Volume: 26, Issue:5

    Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; Carbamyl Phosphate; Citric Acid Cycle; Dietary Proteins; Female; Glutamates; Humans; Male; Ornithine; Proteins; Urea

1981

Trials

1 trial(s) available for n-acetylglutamic acid and ammonium hydroxide

ArticleYear
N-carbamylglutamate markedly enhances ureagenesis in N-acetylglutamate deficiency and propionic acidemia as measured by isotopic incorporation and blood biomarkers.
    Pediatric research, 2008, Volume: 64, Issue:2

    Topics: Acetyl Coenzyme A; Adult; Amino Acids; Ammonia; Biomarkers; Carbon Dioxide; Carbon Isotopes; Child; Feasibility Studies; Female; Glutamates; Humans; Male; Metabolic Diseases; Middle Aged; Propionates; Urea

2008

Other Studies

23 other study(ies) available for n-acetylglutamic acid and ammonium hydroxide

ArticleYear
Normal N-acetylglutamate concentration measured in liver from a new patient with N-acetylglutamate synthetase deficiency: physiologic and biochemical implications.
    Biochemical medicine and metabolic biology, 1992, Volume: 47, Issue:1

    Topics: Acetyltransferases; Amino Acids; Amino-Acid N-Acetyltransferase; Ammonia; Child, Preschool; Crystallization; Glutamates; Humans; Liver; Male; Microscopy, Electron; Mitochondria, Liver; Orotic Acid

1992
Control of urea synthesis and ammonia utilization in protein deprivation and refeeding.
    Archives of biochemistry and biophysics, 1991, Volume: 285, Issue:2

    Topics: Ammonia; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Dietary Proteins; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Liver; Male; Protein Deficiency; Rats; Rats, Inbred Strains; Urea

1991
A smaller initial dose protects mice against several lethal doses of ammonium acetate.
    Biochemical and biophysical research communications, 1990, Mar-30, Volume: 167, Issue:3

    Topics: Acetates; Ammonia; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Glutamates; Male; Mice; Mitochondria, Liver

1990
N-acetylglutamate content in liver and gut of normal and fasted mice, normal human livers, and livers of individuals with carbamyl phosphate synthetase or ornithine transcarbamylase deficiency.
    Pediatric research, 1990, Volume: 27, Issue:4 Pt 1

    Topics: Ammonia; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Fasting; Female; Glutamates; Humans; Intestine, Small; Liver; Liver Cirrhosis; Mice; Mice, Inbred Strains; Ornithine Carbamoyltransferase Deficiency Disease

1990
Effect of thyroid hormones on urea biosynthesis and related processes in rat liver.
    Endocrinology, 1988, Volume: 123, Issue:5

    Topics: Amino Acids; Ammonia; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Cyclic AMP; Glucagon; Glutamates; Hyperthyroidism; Hypothyroidism; Iodide Peroxidase; Liver; Male; Ornithine Carbamoyltransferase; Rats; Rats, Inbred Strains; Thyroid Hormones; Thyroxine; Triiodothyronine; Urea

1988
Protective effect of D,L-carnitine on valproate-induced hyperammonemia and hypoketonemia in primary cultured rat hepatocytes.
    Biochemical pharmacology, 1988, Jun-01, Volume: 37, Issue:11

    Topics: Ammonia; Animals; Carnitine; Cells, Cultured; Glutamates; Ketone Bodies; Liver; Male; Rats; Rats, Inbred Strains; Valproic Acid

1988
The potentiation of ammonia toxicity by sodium benzoate is prevented by L-carnitine.
    Biochemical and biophysical research communications, 1987, Jun-15, Volume: 145, Issue:2

    Topics: Ammonia; Animals; Benzoates; Benzoic Acid; Carnitine; Drug Synergism; Glutamates; Male; Mice; Mitochondria, Liver; Urea

1987
On the mechanism of the protective effect of ethanol against ammonia intoxication in mice.
    Biochemical and biophysical research communications, 1982, Aug-31, Volume: 107, Issue:4

    Topics: Acetates; Ammonia; Animals; Brain; Ethanol; Glutamates; Glutamic Acid; Glutamine; Ketoglutaric Acids; Liver; Male; Mice

1982
Regulation of the n-acetylglutamate content of rat hepatocytes by the glutamate concentration.
    Advances in experimental medicine and biology, 1982, Volume: 153

    Topics: Ammonia; Animals; Aspartic Acid; Citrulline; Diet; Glutamates; Glutamic Acid; Liver; Ornithine; Rats; Urea

1982
Effects of L-carnitine on urea synthesis following acute ammonia intoxication in mice.
    Biochemical and biophysical research communications, 1984, May-16, Volume: 120, Issue:3

    Topics: Ammonia; Animals; Bicarbonates; Carnitine; Glutamates; Male; Mice; Mitochondria, Liver; Sodium Bicarbonate; Urea

1984
Organic acidaemia and Hyperammonaemia: review.
    Journal of inherited metabolic disease, 1981, Volume: 4, Issue:4

    Topics: Acetyl Coenzyme A; Ammonia; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Carboxylic Acids; Coenzyme A; Glutamates; Humans; Metabolism, Inborn Errors; Mitochondria, Liver; Rats

1981
A mechanism for valproate-induced hyperammonemia.
    Advances in experimental medicine and biology, 1982, Volume: 153

    Topics: Ammonia; Animals; Citrulline; Glutamates; Male; Mitochondria, Liver; Oxidation-Reduction; Rats; Rats, Inbred Strains; Urea; Valproic Acid

1982
Low dose ethanol prevents propionate induced hyperammonemia.
    Biochemical and biophysical research communications, 1981, Volume: 100, Issue:4

    Topics: Acetyl Coenzyme A; Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Ethanol; Female; Glutamates; Liver; Propionates; Rats

1981
Failure of the normal ureagenic response to amino acids in organic acid-loaded rats. Proposed mechanism for the hyperammonemia of propionic and methylmalonic acidemia.
    The Journal of clinical investigation, 1980, Volume: 66, Issue:3

    Topics: Acyl Coenzyme A; Adenosine Triphosphate; Ammonia; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Female; Glutamates; Kinetics; Liver; Malonates; Methylmalonic Acid; Ornithine Carbamoyltransferase; Propionates; Rats; Urea

1980
Regulation of urea and citrulline synthesis under physiological conditions.
    The Biochemical journal, 1993, May-15, Volume: 292 ( Pt 1)

    Topics: Amino Acids; Ammonia; Animals; Citrulline; Glutamates; Male; Mitochondria, Liver; Nitrogen; Ornithine; Rats; Rats, Sprague-Dawley; Urea

1993
Regulation of [15N]urea synthesis from [5-15N]glutamine. Role of pH, hormones, and pyruvate.
    The Journal of biological chemistry, 1996, Dec-06, Volume: 271, Issue:49

    Topics: Amino Acids; Ammonia; Animals; Citric Acid Cycle; Citrulline; Gas Chromatography-Mass Spectrometry; Glucagon; Glutamates; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Insulin; Liver; Male; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Urea

1996
Studies of hepatic glutamine metabolism in the perfused rat liver with (15)N-labeled glutamine.
    The Journal of biological chemistry, 1999, Oct-08, Volume: 274, Issue:41

    Topics: Ammonia; Animals; Aspartic Acid; Carbamyl Phosphate; Citrulline; Glucagon; Glutamates; Glutaminase; Glutamine; Insulin; Liver; Male; Nitrogen Isotopes; Oxygen Consumption; Perfusion; Rats; Rats, Sprague-Dawley; Urea

1999
Somatotropin-induced amino acid conservation in pigs involves differential regulation of liver and gut urea cycle enzyme activity.
    The Journal of nutrition, 2002, Volume: 132, Issue:1

    Topics: Amino Acids; Ammonia; Animals; Bicarbonates; Blood Urea Nitrogen; Body Weight; Breath Tests; Carbamyl Phosphate; Carbon Isotopes; Female; Glutamates; Growth Hormone; Jejunum; Liver; Nitrogen; Oxidation-Reduction; Phenylalanine; Random Allocation; Substrate Specificity; Swine; Urea

2002
Hyperammonemia in carnitine-deficient adult JVS mice used by starvation.
    Metabolic brain disease, 2002, Volume: 17, Issue:4

    Topics: Aging; Amino Acids; Ammonia; Animals; Animals, Newborn; Carbamoyl-Phosphate Synthase (Ammonia); Carnitine; Glutamates; Hyperammonemia; Liver; Mice; Mice, Mutant Strains; Starvation; Time Factors; Urea

2002
Role of the glutamate dehydrogenase reaction in furnishing aspartate nitrogen for urea synthesis: studies in perfused rat liver with 15N.
    The Biochemical journal, 2003, Nov-15, Volume: 376, Issue:Pt 1

    Topics: Amino Acids; Ammonia; Animals; Aspartic Acid; Constriction; Freezing; Glutamate Dehydrogenase; Glutamates; Glutamine; Liver; Male; Nitrogen; Nitrogen Isotopes; Perfusion; Rats; Rats, Sprague-Dawley; Urea

2003
New insights on the mechanisms of valproate-induced hyperammonemia: inhibition of hepatic N-acetylglutamate synthase activity by valproyl-CoA.
    Journal of hepatology, 2011, Volume: 55, Issue:2

    Topics: Acyl Coenzyme A; Amino-Acid N-Acetyltransferase; Ammonia; Animals; Anticonvulsants; Citrulline; Disease Models, Animal; Glutamates; Glutamine; Humans; Hyperammonemia; In Vitro Techniques; Liver; Male; Mice; Mice, Inbred C57BL; Models, Biological; Rats; Rats, Wistar; Urea; Valproic Acid

2011
The Study of Carbamoyl Phosphate Synthetase 1 Deficiency Sheds Light on the Mechanism for Switching On/Off the Urea Cycle.
    Journal of genetics and genomics = Yi chuan xue bao, 2015, May-20, Volume: 42, Issue:5

    Topics: Ammonia; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase I Deficiency Disease; Enzyme Stability; Glutamates; Humans; Kinetics; Molecular Dynamics Simulation; Mutation; Protein Structure, Tertiary; Signal Transduction; Urea

2015
Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis.
    Scientific reports, 2015, Nov-23, Volume: 5

    Topics: Amino Acid Motifs; Ammonia; Animals; Baculoviridae; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase I Deficiency Disease; Carbamyl Phosphate; Cloning, Molecular; Crystallography, X-Ray; Gene Expression; Glutamates; Humans; Models, Molecular; Molecular Sequence Data; Mutation; Phosphorylation; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Sf9 Cells; Spodoptera; Substrate Specificity; Urea

2015