n-acetylglucosaminono-1,5-lactone o-(phenylcarbamoyl)oxime has been researched along with acetylglucosamine in 80 studies
| Studies (n-acetylglucosaminono-1,5-lactone o-(phenylcarbamoyl)oxime) | Trials (n-acetylglucosaminono-1,5-lactone o-(phenylcarbamoyl)oxime) | Recent Studies (post-2010) (n-acetylglucosaminono-1,5-lactone o-(phenylcarbamoyl)oxime) | Studies (acetylglucosamine) | Trials (acetylglucosamine) | Recent Studies (post-2010) (acetylglucosamine) |
|---|---|---|---|---|---|
| 88 | 0 | 36 | 5,674 | 31 | 2,001 |
| Protein | Taxonomy | n-acetylglucosaminono-1,5-lactone o-(phenylcarbamoyl)oxime (IC50) | acetylglucosamine (IC50) |
|---|---|---|---|
| Cytochrome P450 3A4 | Homo sapiens (human) | 1.9953 | |
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | 2.5119 | |
| Killer cell lectin-like receptor subfamily B member 1A | Rattus norvegicus (Norway rat) | 2.2536 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (5.00) | 18.2507 |
| 2000's | 33 (41.25) | 29.6817 |
| 2010's | 40 (50.00) | 24.3611 |
| 2020's | 3 (3.75) | 2.80 |
| Authors | Studies |
|---|---|
| Hoesch, L; Horsch, M; Rast, DM; Vasella, A | 1 |
| Aoki, H; Hatanaka, Y; Kikuchi, K; Nagai, T; Nakano, M; Noguchi, S; Takada, M; Yonezawa, N; Yoshizawa, M | 1 |
| Alexander, IJ; Gooday, GW; Hodge, A | 1 |
| Grove, K; Haltiwanger, RS; Philipsberg, GA | 1 |
| Gao, Y; Hart, GW; Parker, GJ | 1 |
| Griffith, LS; Rex-Mathes, M; Schmitz, B; Strutas, D; Thelen, K; Viebahn, C; Werner, S | 1 |
| Okuyama, R; Yachi, M | 1 |
| Hart, GW; Lane, MD; Vosseller, K; Wells, L | 1 |
| Arias, EB; Cartee, GD; Kim, J | 1 |
| Kneass, ZT; Marchase, RB | 1 |
| Arias, EB; Cartee, GD | 1 |
| Acevedo-Duncan, M; Matthews, JA; Potter, RL | 1 |
| Lee, W; Park, SY; Ryu, J | 1 |
| Hanover, JA; Kim, EJ; Perreira, M; Thomas, CJ | 2 |
| Stubbs, KA; Vocadlo, DJ; Zhang, N | 1 |
| Allwood, M; Dorfmueller, HC; Eggleston, IM; Rao, FV; van Aalten, DM; Villa, F | 1 |
| Bijur, GN; Gandy, JC; Rountree, AE | 1 |
| Davies, GJ; Debowski, AW; Dennis, RJ; Shanmugasundaram, B; Vasella, A; Vocadlo, DJ | 1 |
| Acevedo-Duncan, M; Belof, JL; Matthews, JA; Potter, RL | 1 |
| Davies, GJ; Dennis, RJ; Greig, IR; Macauley, MS; Stubbs, KA; Taylor, EJ; Vocadlo, DJ; Whitworth, GE | 1 |
| Chatham, JC; Chaudry, IH; Hu, S; Marchase, RB; Yang, S; Zou, L | 1 |
| Chatham, JC; Liu, J; Marchase, RB | 1 |
| Zachara, NE | 1 |
| An, SH; Byun, HY; Heo, K; Kim, SH; Kim, YH; Lim, S; Oh, YS; Ryu, SH; Song, M; Suh, PG | 1 |
| Kang, Y; Kim, Y; Kwon, H; Park, J | 1 |
| Christeff, N; Gangneux, N; Issad, T; Kuo, M; Zilberfarb, V | 1 |
| Chatham, JC; Chen, YF; Feng, W; Majid-Hassan, E; Miller, AP; Nöt, LG; Oparil, S; Xing, D; Zhang, Y | 1 |
| Scaffidi, A; Stick, RV; Stubbs, KA; Vocadlo, DJ | 1 |
| Alves, CN; Kanaan, N; Lameira, J; Martí, S; Moliner, V; Tuñón, I | 1 |
| Dillmann, W; Facundo, HT; Hamid, T; Jones, SP; Ngoh, GA; Zachara, NE | 1 |
| Cohen, MV; Downey, JM | 1 |
| Asgarali, A; Mark, BL; Oliver, A; Stubbs, KA; Vocadlo, DJ | 1 |
| Balcewich, MD; Davies, GJ; He, Y; James, TW; Mark, BL; Stubbs, KA; Vocadlo, DJ | 1 |
| Cho, JW; Choi, YR; Joo, HJ; Kang, JG; Kim, HS; Moon, WK; Park, SY | 1 |
| Yanagisawa, M; Yu, RK | 1 |
| Macauley, MS; Vocadlo, DJ | 1 |
| Hamid, T; Jones, SP; Ngoh, GA; Prabhu, SD | 1 |
| Balasa, A; Bogner, P; Frank, D; Kotek, G; Kovács, GL; Magyarlaki, T; Miseta, A; Nagy, T; Rab, A; Rideg, O | 1 |
| Chen, WH; Ho, CW; Ho, MJ; Lin, CH; Liu, TW; Popat, SD; Tsai, KC; Yang, AS | 1 |
| Alves, CN; Castillo, R; Lameira, J; Martí, S; Moliner, V; Tuñón, I | 1 |
| Goddard-Borger, ED; Stubbs, KA | 1 |
| Asahi, M; Miyoshi, E; Otsu, K; Suzuki, K; Takeda, T; Taniguchi, N; Yokoe, S | 1 |
| Ku, NO; Omary, MB; Strnad, P; Toivola, DM | 1 |
| Coulombe, PA; Hart, GW; Rotty, JD | 1 |
| Davies, GJ; Gloster, TM; He, Y; Macauley, MS; Stubbs, KA; Vocadlo, DJ | 1 |
| Eguchi, H; Fujiwara, N; Noguchi, T; Sakiyama, H; Suzuki, K; Uyeda, K; Yoshihara, D | 1 |
| Iverfeldt, K; Jacobsen, KT | 1 |
| Jóźwiak, P; Krześlak, A; Lipińska, A | 1 |
| Chen, L; Liu, F; Liu, T; Shen, X; Yang, Q; Zhang, H | 1 |
| Chatham, JC; Chen, YF; Feng, W; Gong, K; Nozell, SE; Oparil, S; Xing, D | 1 |
| Douglas, CW; Honma, K; Phansopa, C; Roy, S; Sharma, A; Stafford, GP; Stafford, P | 1 |
| Duvet, S; Foulquier, F; Lefebvre, T; Legrand, D; Mehdy, A; Morelle, W; Rosnoblet, C | 1 |
| Guo, L; Li, J; Li, T; Li, Z; Lin, L; Wang, P; Xu, Y; Zhang, Y; Zhao, W | 1 |
| Chen, CL; Chen, JT; Chen, YH; Liang, CM; Lu, DW; Tai, MC | 1 |
| Ghosh, S; Hanover, JA; Hart, GW; Lewis, BA; Ranuncolo, SM | 1 |
| Alves, CN; de Alencar, NA; Lameira, J; Martí, S; Moliner, V; Silva, JR; Sousa, PR | 1 |
| Jin, FZ; Wu, MJ; Yang, Z; Yu, C; Zhao, DZ | 1 |
| Ding, F; Fu, G; Wang, M; Xia, Q; Xu, S; Yu, L | 1 |
| Alarcón, L; Giannakouros, T; González-Mariscal, L; Ponce, A; Quiros, M | 1 |
| Fardini, Y; Hampe, C; Issad, T; Kanwal, S; Masson, E; N'tumba-Byn, T; Pagesy, P; Pierre-Eugène, C | 1 |
| Baek, MC; Lee, JE; Moon, PG; Park, JH | 2 |
| Dehennaut, V; Lefebvre, T | 1 |
| Bernier, J; Johnson, B; Opimba, M | 1 |
| Goodwin, OY; Lin, AJ; Macnaughtan, MA; Sweeney, MM; Thomasson, MS | 1 |
| Choi, JH; Han, HJ; Kim, DI; Lim, SK; Park, MJ; Park, SH; Yoon, KC | 1 |
| Endo, T; Hiraoka, W; Miura, Y; Sakai, R; Sakurai, Y; Sato, T | 1 |
| Filgueira, FP; Giachini, FR; Lima, VV; Lobato, NS; Tostes, RC; Webb, RC | 1 |
| Chun, YS; Chung, S; Kim, TW; Oh, HG; Park, MK; Park, Y; Yang, HO | 1 |
| Bai, B; Jiang, K; Ta, Y; Wang, PG; Xiao, Z; Zhang, L; Zhang, T | 1 |
| El-Karim, EG; Teo, CF; Wells, L | 1 |
| Bae, DJ; Chang, JH; Cho, DH; Jo, DS; Jo, YK; Kim, BG; Kim, JC; Kim, SY; Lee, EK; Park, NY; Park, SJ; Shin, JH; Suh, YA | 1 |
| Blazquez, J; Chu, M; Hamou-Segarra, M; Hattie, M; Juan, C; Mark, BL; Oliver, A; Sanchez-Diener, I; Stubbs, KA; Vadlamani, G; Zamorano, L | 1 |
| Blériot, Y; Désiré, J; Mark, BL; Stubbs, KA; Vadlamani, G; Vocadlo, DJ | 1 |
| Okuda, T | 1 |
| Chan, JY; Han, JW; Ho, DV; Huang, L; Kim, HM; Lee, CS; Valdez, JL; Wang, X | 1 |
| Hwang, JS; Shin, YJ; Yoon, CK; Yoon, SY | 1 |
| Cho, H; Han, IO; Jung, EH; Kim, SM; Lee, Y; Park, J | 1 |
| Aydogdu, G; Sermikli, BP; Yilmaz, E | 1 |
1 review(s) available for n-acetylglucosaminono-1,5-lactone o-(phenylcarbamoyl)oxime and acetylglucosamine
| Article | Year |
|---|---|
Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase.
Topics: Acetylglucosamine; Acetylglucosaminidase; Animals; Catalytic Domain; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; N-Acetylglucosaminyltransferases; Oximes; Phenylcarbamates; Pyrazoles; Pyridines; Streptozocin; Thiazoles; Uridine Diphosphate N-Acetylglucosamine | 2010 |
79 other study(ies) available for n-acetylglucosaminono-1,5-lactone o-(phenylcarbamoyl)oxime and acetylglucosamine
| Article | Year |
|---|---|
N-acetylglucosaminono-1,5-lactone oxime and the corresponding (phenylcarbamoyl)oxime. Novel and potent inhibitors of beta-N-acetylglucosaminidase.
Topics: Acetylglucosamine; Acetylglucosaminidase; Animals; Cattle; Fungi; Kinetics; Lactones; Oximes; Phenylcarbamates | 1991 |
pH-sensitive dissociation and association of beta-N-acetylhexosaminidase from boar sperm acrosome.
Topics: Acetylglucosamine; Acrosome; Animals; beta-N-Acetylhexosaminidases; Calcimycin; Chromatography, Gel; Chromatography, Ion Exchange; Enzyme Stability; Female; Fertilization in Vitro; Hydrogen-Ion Concentration; Kinetics; Male; Molecular Weight; Oximes; Phenylcarbamates; Sperm-Ovum Interactions; Swine | 1994 |
Inhibition of chitinolytic activities from tree species and associated fungi.
Topics: Acetylglucosamine; Carbohydrate Sequence; Chitinases; Enzyme Inhibitors; Eucalyptus; Fungi; Kinetics; Molecular Sequence Data; Oligosaccharides; Oximes; Phenylcarbamates; Plants, Medicinal; Species Specificity; Substrate Specificity; Trees; Trisaccharides | 1996 |
Modulation of O-linked N-acetylglucosamine levels on nuclear and cytoplasmic proteins in vivo using the peptide O-GlcNAc-beta-N-acetylglucosaminidase inhibitor O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate.
Topics: Acetylglucosamine; Acetylglucosaminidase; beta-N-Acetylhexosaminidases; Cell Line; Cell Nucleus; Cytoplasm; Enzyme Inhibitors; Glycosylation; HeLa Cells; Histone Acetyltransferases; Humans; Multienzyme Complexes; Oximes; Phenylcarbamates | 1998 |
Streptozotocin-induced beta-cell death is independent of its inhibition of O-GlcNAcase in pancreatic Min6 cells.
Topics: Acetylglucosamine; Acetylglucosaminidase; Animals; Apoptosis; Benzamides; beta-N-Acetylhexosaminidases; Blotting, Western; Brain; Cattle; Cell Death; Cell Line; Cell Nucleus; DNA Fragmentation; Dose-Response Relationship, Drug; Histone Acetyltransferases; Immunoblotting; Insulin; Islets of Langerhans; Mice; Multienzyme Complexes; Oximes; Pancreas; Phenylcarbamates; Poly(ADP-ribose) Polymerases; Streptozocin; Time Factors | 2000 |
O-GlcNAc expression in developing and ageing mouse brain.
Topics: Acetylgalactosamine; Acetylglucosamine; Aging; Animals; Antibodies, Monoclonal; Blotting, Western; Brain; Cells, Cultured; Cerebellum; Embryo, Mammalian; Enzyme Inhibitors; Fluorescent Antibody Technique, Direct; Gene Expression; Immunohistochemistry; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Neurons; Oximes; Phenylcarbamates; Protein Binding; Substrate Specificity | 2001 |
Cytosolic O-GlcNAc accumulation is not involved in beta-cell death in HIT-T15 or Min6.
Topics: Acetylglucosamine; Acetylglucosaminidase; Animals; beta-N-Acetylhexosaminidases; Cell Death; Cells, Cultured; Cricetinae; Cytosol; Energy Metabolism; Glucosamine; Histone Acetyltransferases; Islets of Langerhans; Multienzyme Complexes; Oximes; Phenylcarbamates | 2001 |
Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Acetylglucosamine; Adipocytes; Animals; beta Catenin; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Catalysis; Cell Line; Cell Nucleus; Cytoplasm; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Glucosamine; Glucose; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Glycosylation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Oximes; Phenylcarbamates; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Time Factors; Trans-Activators; Tyrosine | 2002 |
Prolonged incubation in PUGNAc results in increased protein O-Linked glycosylation and insulin resistance in rat skeletal muscle.
Topics: Acetylglucosamine; Animals; Biological Transport; Glucose; Glycosylation; Insulin; Insulin Resistance; Kinetics; Male; Muscle Proteins; Muscle, Skeletal; Oximes; Phenylcarbamates; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Rats; Rats, Wistar | 2004 |
Protein O-GlcNAc modulates motility-associated signaling intermediates in neutrophils.
Topics: Acetylglucosamine; Androstadienes; Cell Movement; Chemotaxis; Enzyme Activation; Enzyme Inhibitors; Guanosine Triphosphate; Humans; Immunoblotting; Leukocytes, Mononuclear; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oximes; p38 Mitogen-Activated Protein Kinases; Phenylcarbamates; Phosphatidylinositol 3-Kinases; rac GTP-Binding Proteins; Signal Transduction; Time Factors; Wortmannin | 2005 |
Relationship between protein O-linked glycosylation and insulin-stimulated glucose transport in rat skeletal muscle following calorie restriction or exposure to O-(2-acetamido-2-deoxy-d-glucopyranosylidene)amino-N-phenylcarbamate.
Topics: Acetylglucosamine; Animals; beta-N-Acetylhexosaminidases; Biological Transport, Active; Caloric Restriction; Electrophoresis, Polyacrylamide Gel; Glucose; Glycosylation; Insulin; Insulin Resistance; Liver; Male; Muscle Proteins; Muscle, Skeletal; Oximes; Phenylcarbamates; Rats; Rats, Inbred F344; Tissue Culture Techniques | 2005 |
Selective decrease of membrane-associated PKC-alpha and PKC-epsilon in response to elevated intracellular O-GlcNAc levels in transformed human glial cells.
Topics: Acetylglucosamine; Cell Line, Transformed; Cell Membrane; Cytosol; Electrophoresis, Polyacrylamide Gel; Glucosamine; Humans; Immunoblotting; N-Acetylglucosaminyltransferases; Neuroglia; Oximes; Phenylcarbamates; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Streptozocin | 2005 |
O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes.
Topics: Acetylglucosamine; Adipocytes; Animals; beta-N-Acetylhexosaminidases; Deoxyglucose; Glucose Transporter Type 5; Glycosylation; Immunoprecipitation; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Monosaccharide Transport Proteins; Oximes; Phenylcarbamates; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Subcellular Fractions | 2005 |
Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry.
Topics: Acetylglucosamine; Acetylglucosaminidase; beta-N-Acetylhexosaminidases; Cell Line; Enzyme Inhibitors; HeLa Cells; Histone Acetyltransferases; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Multienzyme Complexes; Oximes; Phenylcarbamates; Recombinant Proteins; Stereoisomerism | 2006 |
A divergent synthesis of 2-acyl derivatives of PUGNAc yields selective inhibitors of O-GlcNAcase.
Topics: Acetylglucosamine; beta-N-Acetylhexosaminidases; Biochemistry; Enzyme Inhibitors; Humans; Oximes; Phenylcarbamates; Structure-Activity Relationship | 2006 |
Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis.
Topics: 3T3 Cells; Acetylglucosamine; Acetylglucosaminidase; Amino Acid Sequence; Animals; beta-N-Acetylhexosaminidases; Binding Sites; Catalysis; Clostridium perfringens; Crystallography, X-Ray; Glycosylation; Histone Acetyltransferases; Humans; Hydrolysis; Mice; Models, Molecular; Molecular Sequence Data; Multienzyme Complexes; Mutation; Oximes; Phenylcarbamates; Phosphorylation; Protein Conformation; Sequence Homology, Amino Acid; Streptozocin; Substrate Specificity | 2006 |
An O-GlcNAcase-specific inhibitor and substrate engineered by the extension of the N-acetyl moiety.
Topics: Acetylglucosamine; Acetylglucosaminidase; beta-N-Acetylhexosaminidases; Drug Design; Enzyme Inhibitors; Histone Acetyltransferases; Multienzyme Complexes; Oximes; Phenylcarbamates; Substrate Specificity | 2006 |
Akt1 is dynamically modified with O-GlcNAc following treatments with PUGNAc and insulin-like growth factor-1.
Topics: Acetylglucosamine; Cell Line, Tumor; Cell Nucleus; Cytosol; Glycoproteins; Humans; Insulin-Like Growth Factor I; Oximes; Phenylcarbamates; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt | 2006 |
Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor.
Topics: Acetylglucosamine; beta-N-Acetylhexosaminidases; Enzyme Inhibitors; Histone Acetyltransferases; Humans; Imidazoles; Models, Chemical; Molecular Structure; Oximes; Phenylcarbamates; Pyrazoles; Pyridines; Stereoisomerism | 2006 |
Glucosamine-induced increase in Akt phosphorylation corresponds to increased endoplasmic reticulum stress in astroglial cells.
Topics: Acetylcysteine; Acetylglucosamine; Astrocytes; Cell Line; Cell Membrane; Cytosol; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Enzyme Induction; Galactosamine; Glucosamine; Heat-Shock Proteins; Humans; Molecular Chaperones; Osmotic Pressure; Oxidative Stress; Oximes; Phenylcarbamates; Phosphorylation; Protein Processing, Post-Translational; Protein Transport; Proto-Oncogene Proteins c-akt; Streptozocin | 2007 |
Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise.
Topics: Acetylglucosamine; beta-N-Acetylhexosaminidases; Catalysis; Crystallography, X-Ray; Enzyme Activation; Enzyme Inhibitors; Glycosylation; Humans; Models, Molecular; Oximes; Phenylcarbamates; Substrate Specificity; Thermodynamics; Thiazoles | 2007 |
The protective effects of PUGNAc on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levels.
Topics: Acetylglucosamine; Animals; Glycoproteins; Glycosylation; Heart; Heart Injuries; Hemorrhage; Male; N-Acetylglucosaminyltransferases; Oximes; Phenylcarbamates; Rats; Rats, Sprague-Dawley | 2007 |
Increased O-GlcNAc levels during reperfusion lead to improved functional recovery and reduced calpain proteolysis.
Topics: Acetylglucosamine; Adenosine Triphosphate; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calpain; Carrier Proteins; Glucosamine; Microfilament Proteins; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Oximes; Phenylcarbamates; Rats | 2007 |
The sweet nature of cardioprotection.
Topics: Acetylglucosamine; Animals; beta-N-Acetylhexosaminidases; Glucosamine; Myocardial Reperfusion Injury; Myocardium; Oximes; Phenylcarbamates; Rats | 2007 |
O-GlcNAc modification modulates the expression of osteocalcin via OSE2 and Runx2.
Topics: 3T3 Cells; Acetylglucosamine; Animals; Ascorbic Acid; beta-N-Acetylhexosaminidases; Binding Sites; Blotting, Western; Cell Differentiation; Chlorocebus aethiops; Core Binding Factor Alpha 1 Subunit; COS Cells; Gene Expression Regulation; Luciferases; Mice; Osteoblasts; Osteocalcin; Oximes; Phenylcarbamates; Promoter Regions, Genetic; Protein Binding; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection | 2007 |
Proteomic analysis of O-GlcNAc modifications derived from streptozotocin and glucosamine induced beta-cell apoptosis.
Topics: Acetylglucosamine; Animals; Apoptosis; Cell Line; Diabetes Mellitus, Type 2; Glucosamine; Glycosylation; Insulin; Insulin Secretion; Insulin-Secreting Cells; Models, Biological; Oximes; Phenylcarbamates; Proteomics; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Streptozocin | 2007 |
O-glycosylation of FoxO1 increases its transcriptional activity towards the glucose 6-phosphatase gene.
Topics: Acetylglucosamine; Cell Line; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation, Enzymologic; Genes, Reporter; Glucosamine; Glucose-6-Phosphatase; Glycosylation; Humans; Luciferases; Oximes; Phenylcarbamates; Promoter Regions, Genetic; Transcription, Genetic | 2008 |
Increased protein O-GlcNAc modification inhibits inflammatory and neointimal responses to acute endoluminal arterial injury.
Topics: Acetylglucosamine; Animals; Anti-Inflammatory Agents; Carotid Arteries; Carotid Artery Injuries; Disease Models, Animal; Female; Glucosamine; Glycosylation; Inflammation Mediators; Monocytes; Neutrophil Infiltration; Ovariectomy; Oximes; Phenylcarbamates; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
The synthesis and biological evaluation of some carbocyclic analogues of PUGNAc.
Topics: Acetylglucosamine; Enzyme Inhibitors; Models, Molecular; Molecular Structure; N-Acetylglucosaminyltransferases; Oximes; Phenylcarbamates; Structure-Activity Relationship | 2008 |
A quantum mechanics/molecular mechanics study of the protein-ligand interaction of two potent inhibitors of human O-GlcNAcase: PUGNAc and NAG-thiazoline.
Topics: Acetylglucosamine; beta-N-Acetylhexosaminidases; Binding Sites; Biocatalysis; Drug Design; Enzyme Inhibitors; Humans; Ligands; Models, Molecular; Molecular Conformation; Oximes; Phenylcarbamates; Protein Binding; Protons; Quantum Theory; Static Electricity; Thermodynamics; Thiazoles | 2008 |
Unique hexosaminidase reduces metabolic survival signal and sensitizes cardiac myocytes to hypoxia/reoxygenation injury.
Topics: Acetylglucosamine; Animals; Animals, Newborn; beta-N-Acetylhexosaminidases; Calcium; Cardiotonic Agents; Cell Hypoxia; Cell Survival; Cells, Cultured; Glycosylation; Ischemic Preconditioning, Myocardial; Membrane Potential, Mitochondrial; Mice; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Ischemia; Myocytes, Cardiac; Oximes; Phenylcarbamates; Protein Biosynthesis; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; RNA Interference; RNA, Small Interfering | 2009 |
O-linked beta-N-acetylglucosamine: a new piece of the cardioprotection puzzle?
Topics: Acetylglucosamine; Animals; beta-N-Acetylhexosaminidases; Carbohydrate Conformation; Cardiotonic Agents; Cells, Cultured; Glycosylation; Humans; Ischemic Preconditioning, Myocardial; Mice; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Ischemia; Myocytes, Cardiac; N-Acetylglucosaminyltransferases; Oximes; Phenylcarbamates; Protein Processing, Post-Translational; Rats; Voltage-Dependent Anion Channels | 2009 |
Inactivation of the glycoside hydrolase NagZ attenuates antipseudomonal beta-lactam resistance in Pseudomonas aeruginosa.
Topics: Acetylglucosamine; Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; Glycoside Hydrolases; Microbial Sensitivity Tests; Oximes; Phenylcarbamates; Pseudomonas aeruginosa | 2009 |
Insight into a strategy for attenuating AmpC-mediated beta-lactam resistance: structural basis for selective inhibition of the glycoside hydrolase NagZ.
Topics: Acetylglucosamine; Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; beta-N-Acetylhexosaminidases; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Oximes; Phenylcarbamates; Protein Binding; Protein Conformation; Recombinant Fusion Proteins | 2009 |
Excessive O-GlcNAcylation of proteins suppresses spontaneous cardiogenesis in ES cells.
Topics: Acetylglucosamine; Acetylglucosaminidase; Animals; Cell Differentiation; Cell Line; Embryonic Stem Cells; Female; Gene Knock-In Techniques; Heart; Humans; Infant; Mice; Myocardium; Oximes; Phenylcarbamates; Streptozocin | 2009 |
O-linked beta-N-acetylglucosaminylation in mouse embryonic neural precursor cells.
Topics: Acetylglucosamine; Alloxan; Animals; Blotting, Western; Butadienes; Caspase 3; Cell Count; Cell Death; Cells, Cultured; Chromones; Embryonic Stem Cells; Extracellular Signal-Regulated MAP Kinases; Immunohistochemistry; MAP Kinase Kinase Kinases; Mice; Morpholines; N-Acetylglucosaminyltransferases; Neurons; Nitriles; Oximes; Phenylcarbamates; Phosphatidylinositol 3-Kinases; Protein Processing, Post-Translational; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sp1 Transcription Factor; Streptozocin; Tunicamycin | 2009 |
O-GlcNAc signaling attenuates ER stress-induced cardiomyocyte death.
Topics: Acetylglucosamine; Adaptation, Physiological; Animals; Animals, Newborn; beta-N-Acetylhexosaminidases; Brefeldin A; Cell Death; Cell Hypoxia; Cells, Cultured; Cytoprotection; Endoplasmic Reticulum; Enzyme Inhibitors; Myocardial Reperfusion Injury; Myocytes, Cardiac; N-Acetylglucosaminyltransferases; Oximes; Phenylcarbamates; Rats; Rats, Sprague-Dawley; Signal Transduction; Stress, Physiological; Transcription Factor CHOP; Transfection; Tunicamycin | 2009 |
O-GlcNAc modification of proteins affects volume regulation in Jurkat cells.
Topics: Acetylglucosamine; Apoptosis; Blotting, Western; Cell Cycle; Cell Membrane; Cell Size; Diffusion; Enzyme Inhibitors; Fluorescence; Glucose; Glycosylation; Humans; Intracellular Space; Jurkat Cells; Nuclear Magnetic Resonance, Biomolecular; Oximes; Phenylcarbamates; Stress, Physiological; Time Factors; Water | 2010 |
Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.
Topics: Acetylglucosamine; Animals; beta-N-Acetylhexosaminidases; Blotting, Western; Cell Line; Enzyme Inhibitors; Fluorescent Antibody Technique; G(M2) Ganglioside; Glycosphingolipids; Humans; Immunohistochemistry; Kinetics; Mice; Microglia; Models, Molecular; Oximes; Phenylcarbamates; Streptozocin | 2010 |
Quantum mechanical/molecular mechanical molecular dynamics simulation of wild-type and seven mutants of CpNagJ in complex with PUGNAc.
Topics: Acetylglucosamine; Amino Acid Substitution; beta-N-Acetylhexosaminidases; Clostridium perfringens; Crystallography, X-Ray; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Oximes; Phenylcarbamates; Protein Binding; Quantum Theory; Static Electricity; Thermodynamics | 2010 |
An improved route to PUGNAc and its galacto-configured congener.
Topics: Acetylglucosamine; Galactose; Glycosylation; Methods; Oximes; Phenylcarbamates | 2010 |
Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy.
Topics: Acetylglucosamine; Acylation; Animals; beta-N-Acetylhexosaminidases; Blotting, Western; Calcium; Calcium-Binding Proteins; Catecholamines; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; HeLa Cells; Humans; Immunoprecipitation; Male; Mutagenesis, Site-Directed; Mutation; Myocytes, Cardiac; N-Acetylglucosaminyltransferases; Oximes; Phenylcarbamates; Phosphorylation; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2010 |
Cytoskeletal keratin glycosylation protects epithelial tissue from injury.
Topics: Acetylglucosamine; Amino Acid Substitution; Animals; Antibodies, Monoclonal; Apoptosis; beta-N-Acetylhexosaminidases; Caspase 3; Chemical and Drug Induced Liver Injury; Cytoskeleton; Cytosol; Enzyme Inhibitors; fas Receptor; Glycogen Synthase Kinase 3; Glycosylation; Hepatocytes; HSP70 Heat-Shock Proteins; Humans; Keratin-18; Keratin-8; Keratins; Liver; Mice; Mice, Inbred Strains; Mice, Knockout; Mice, Transgenic; Models, Biological; Oximes; Pancreas; Phenylcarbamates; Phosphorylation; Protein Binding; Protein Kinase C-delta; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Streptozocin | 2010 |
Stressing the role of O-GlcNAc: linking cell survival to keratin modification.
Topics: Acetylglucosamine; Animals; Apoptosis; beta-N-Acetylhexosaminidases; Cell Survival; Chemical and Drug Induced Liver Injury; fas Receptor; Glycosylation; Humans; Keratin-18; Keratin-8; Keratins; Models, Biological; Oximes; Phenylcarbamates; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Streptozocin | 2010 |
Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Acetylglucosamine; Adipocytes; Animals; beta-N-Acetylhexosaminidases; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Deoxyglucose; Enzyme Inhibitors; Humans; Indolizines; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Oximes; Phenylcarbamates; Phosphorylation; Proto-Oncogene Proteins c-akt | 2010 |
The role of O-linked GlcNAc modification on the glucose response of ChREBP.
Topics: Acetylglucosamine; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; beta-N-Acetylhexosaminidases; Cell Line; Glucose; Glycosylation; Humans; Mutation; Oximes; Phenylcarbamates; Transcription, Genetic | 2010 |
O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-β precursor protein (APP).
Topics: Acetylglucosamine; Acylation; Alzheimer Disease; Amyloid beta-Protein Precursor; beta-N-Acetylhexosaminidases; Cell Line, Tumor; Gene Knockdown Techniques; Humans; N-Acetylglucosaminyltransferases; Oximes; Phenylcarbamates; RNA, Small Interfering | 2011 |
Down-regulation of β-N-acetyl-D-glucosaminidase increases Akt1 activity in thyroid anaplastic cancer cells.
Topics: Acetylglucosamine; beta-N-Acetylhexosaminidases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; Down-Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Insulin-Like Growth Factor I; Oximes; Phenylcarbamates; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA Interference; Thyroid Neoplasms | 2011 |
Active-pocket size differentiating insectile from bacterial chitinolytic β-N-acetyl-D-hexosaminidases.
Topics: Acetylglucosamine; Animals; beta-N-Acetylhexosaminidases; Catalytic Domain; Chitin; Lepidoptera; Models, Molecular; Oximes; Phenylcarbamates; Protein Conformation | 2011 |
O-GlcNAc modification of NFκB p65 inhibits TNF-α-induced inflammatory mediator expression in rat aortic smooth muscle cells.
Topics: Acetylglucosamine; Animals; Aorta; Blotting, Western; Cells, Cultured; Immunoprecipitation; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oximes; Phenylcarbamates; Phosphorylation; Rats; Real-Time Polymerase Chain Reaction; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2011 |
Beta-hexosaminidase activity of the oral pathogen Tannerella forsythia influences biofilm formation on glycoprotein substrates.
Topics: Acetylglucosamine; Bacteroidetes; beta-N-Acetylhexosaminidases; Biofilms; Galactosamine; Glucosamine; Glycoproteins; Humans; Oximes; Phenylcarbamates | 2012 |
PUGNAc treatment leads to an unusual accumulation of free oligosaccharides in CHO cells.
Topics: Acetylglucosamine; Animals; beta-N-Acetylhexosaminidases; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; CHO Cells; Cricetinae; Cytosol; Glycoproteins; Glycosylation; Oligosaccharides; Oximes; Phenylcarbamates; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2012 |
Identification of a specific inhibitor of nOGA - a caspase-3 cleaved O-GlcNAcase variant during apoptosis.
Topics: Acetylglucosamine; Apoptosis; beta-N-Acetylhexosaminidases; Binding Sites; Caspase 3; Catalytic Domain; Enzyme Inhibitors; Hexosaminidase A; Hexosaminidase B; Humans; Kinetics; Oximes; Phenylcarbamates; Protein Isoforms; Recombinant Proteins; Substrate Specificity; Triazoles | 2012 |
Glucosamine modulates TNF-α-induced ICAM-1 expression and function through O-linked and N-linked glycosylation in human retinal pigment epithelial cells.
Topics: Acetylglucosamine; Alloxan; beta-N-Acetylhexosaminidases; Blotting, Western; Cell Adhesion; Cell Line; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Flow Cytometry; Glucosamine; Glycosylation; Humans; Intercellular Adhesion Molecule-1; Microscopy, Fluorescence; N-Acetylglucosaminyltransferases; NF-kappa B; Oximes; Phenylcarbamates; Retinal Pigment Epithelium; Signal Transduction; Tumor Necrosis Factor-alpha | 2012 |
Evidence of the involvement of O-GlcNAc-modified human RNA polymerase II CTD in transcription in vitro and in vivo.
Topics: Acetylglucosamine; Acetylglucosaminidase; Binding Sites; Blotting, Western; Cell Line, Tumor; Chromatin Immunoprecipitation; Enzyme Inhibitors; Gene Expression Regulation; HeLa Cells; Humans; N-Acetylglucosaminyltransferases; Oximes; Phenylcarbamates; Promoter Regions, Genetic; Protein Binding; Protein Processing, Post-Translational; Protein Subunits; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA Polymerase II; Serine; Transcription, Genetic | 2012 |
Computational analysis of human OGA structure in complex with PUGNAc and NAG-thiazoline derivatives.
Topics: Acetylglucosamine; Bacterial Proteins; Bacteroides; beta-N-Acetylhexosaminidases; Binding Sites; Clostridium perfringens; Crystallography, X-Ray; Humans; Isoenzymes; Kinetics; Ligands; Molecular Docking Simulation; Oximes; Phenylcarbamates; Protein Binding; Protein Conformation; Structural Homology, Protein; Thermodynamics; Thiazoles | 2012 |
A correlation between altered O-GlcNAcylation, migration and with changes in E-cadherin levels in ovarian cancer cells.
Topics: Acetylglucosamine; Antigens, CD; beta Catenin; Blotting, Western; Cadherins; Catenins; Cell Adhesion; Cell Line, Tumor; Cell Movement; Delta Catenin; Female; Gene Silencing; Glycosylation; Humans; Multiprotein Complexes; N-Acetylglucosaminyltransferases; Ovarian Neoplasms; Oximes; Phenylcarbamates; Pyrans; RNA, Messenger; RNA, Small Interfering; Thiazoles; Transfection | 2013 |
O-GlcNAcylation involvement in high glucose-induced cardiac hypertrophy via ERK1/2 and cyclin D2.
Topics: Acetylglucosamine; Acetylglucosaminidase; Animals; Cardiomegaly; Cyclin D2; Diabetes Mellitus, Experimental; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glucose; Glycosylation; Heart; JNK Mitogen-Activated Protein Kinases; Male; Myocardium; Myocytes, Cardiac; N-Acetylglucosaminyltransferases; Oximes; p38 Mitogen-Activated Protein Kinases; Phenylcarbamates; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Signal Transduction; Streptozocin | 2013 |
The intracellular fate of zonula occludens 2 is regulated by the phosphorylation of SR repeats and the phosphorylation/O-GlcNAcylation of S257.
Topics: Acetylglucosamine; Active Transport, Cell Nucleus; Animals; beta-N-Acetylhexosaminidases; Cell Line; Cell Membrane; Cell Nucleus; Cell Proliferation; Dogs; Epidermal Growth Factor; Glycosylation; Madin Darby Canine Kidney Cells; Mitogen-Activated Protein Kinase Kinases; Nuclear Export Signals; Nuclear Localization Signals; Oximes; Phenylcarbamates; Phosphorylation; Protein Kinase C-delta; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Tight Junctions; Zonula Occludens-2 Protein | 2013 |
O-GlcNAcylation-inducing treatments inhibit estrogen receptor α expression and confer resistance to 4-OH-tamoxifen in human breast cancer-derived MCF-7 cells.
Topics: Acetylglucosamine; Antineoplastic Agents, Hormonal; Biosynthetic Pathways; Breast Neoplasms; Cell Death; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Hexosamines; Humans; Insulin-Like Growth Factor I; MCF-7 Cells; Oximes; Phenylcarbamates; Phosphatidylinositol 3-Kinases; Promoter Regions, Genetic; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Selective Estrogen Receptor Modulators; Signal Transduction; Tamoxifen | 2013 |
Identification of differentially expressed proteins by treatment with PUGNAc in 3T3-L1 adipocytes through analysis of ATP-binding proteome.
Topics: 3T3-L1 Cells; Acetylglucosamine; Adenosine Triphosphate; Adipocytes; Animals; Chromatography, Affinity; Down-Regulation; Glycosylation; HSP90 Heat-Shock Proteins; Mice; Muscle Fibers, Skeletal; Oximes; Phenylcarbamates; Phosphorylation; Protein Binding; Protein Interaction Maps; Proteome; Proteomics; Proto-Oncogene Proteins c-akt; Reproducibility of Results; RNA, Small Interfering; Ubiquitination | 2013 |
Proteomics and PUGNAcity will overcome questioning of insulin resistance induction by nonselective inhibition of O-GlcNAcase.
Topics: 3T3-L1 Cells; Acetylglucosamine; Animals; beta-N-Acetylhexosaminidases; Chromatography, Affinity; Glycosylation; Hep G2 Cells; Humans; Insulin Resistance; Mice; Oximes; Phenylcarbamates; Proteomics | 2013 |
Implications of the O-GlcNAc modification in the regulation of nuclear apoptosis in T cells.
Topics: Acetylglucosamine; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Cell Cycle; Cell Nucleus; Electrophoresis, Gel, Two-Dimensional; Glycosylation; Humans; Immunoprecipitation; Leukemia-Lymphoma, Adult T-Cell; Myocytes, Cardiac; N-Acetylglucosaminyltransferases; Oximes; Phenylcarbamates; Protein Processing, Post-Translational; Proteins; Signal Transduction; Trialkyltin Compounds | 2014 |
E. coli sabotages the in vivo production of O-linked β-N-acetylglucosamine-modified proteins.
Topics: Acetylglucosamine; Acetylglucosaminidase; Cell Nucleus; Cyclic AMP Response Element-Binding Protein; Cytosol; Escherichia coli; Gene Expression Regulation, Bacterial; Glycosylation; Humans; N-Acetylglucosaminyltransferases; Oximes; Peptides; Phenylcarbamates; Protein Processing, Post-Translational; Protein-Tyrosine Kinases | 2013 |
High glucose-induced O-GlcNAcylated carbohydrate response element-binding protein (ChREBP) mediates mesangial cell lipogenesis and fibrosis: the possible role in the development of diabetic nephropathy.
Topics: Acetylglucosamine; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; beta-N-Acetylhexosaminidases; Cholesterol; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fibrosis; Gene Expression Regulation, Enzymologic; Glucose; HEK293 Cells; Humans; Lipogenesis; Mesangial Cells; Oximes; Phenylcarbamates; Rats; Sweetening Agents; Triglycerides | 2014 |
Hyper-O-GlcNAcylation inhibits the induction of heat shock protein 70 (Hsp 70) by sodium arsenite in HeLa cells.
Topics: Acetylglucosamine; Acylation; Arsenites; DNA-Binding Proteins; Glucosamine; Heat Shock Transcription Factors; HeLa Cells; HSP70 Heat-Shock Proteins; Humans; N-Acetylglucosaminyltransferases; Oxidative Stress; Oximes; Phenylcarbamates; Protein Processing, Post-Translational; RNA, Messenger; RNA, Small Interfering; Sodium Compounds; Transcription Factors | 2014 |
Vascular O-GlcNAcylation augments reactivity to constrictor stimuli by prolonging phosphorylated levels of the myosin light chain.
Topics: Acetylglucosamine; Acylation; Aminoimidazole Carboxamide; Animals; Aorta, Thoracic; Azepines; beta-N-Acetylhexosaminidases; Blotting, Western; Enzyme Inhibitors; Hypoglycemic Agents; Male; Marine Toxins; Muscle, Smooth, Vascular; Myosin Light Chains; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Oxazoles; Oximes; Phenylcarbamates; Phenylephrine; Phosphorylation; Protein Processing, Post-Translational; Rats, Wistar; Ribonucleotides; Vasoconstriction; Vasoconstrictor Agents | 2014 |
O-GlcNAcylation promotes non-amyloidogenic processing of amyloid-β protein precursor via inhibition of endocytosis from the plasma membrane.
Topics: Acetylglucosamine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Cell Membrane; CHO Cells; Clathrin; Cricetulus; Dose-Response Relationship, Drug; Endocytosis; HeLa Cells; Humans; Mutation; N-Acetylglucosaminyltransferases; Oximes; Phenylcarbamates; Protein Processing, Post-Translational; Protein Transport; Time Factors; Transfection | 2015 |
PUGNAc induces protein ubiquitination in C2C12 myotube cells.
Topics: Acetylglucosamine; Adenosine Triphosphate; Animals; Blotting, Western; Cell Line; Glucosides; Mice; Molecular Sequence Annotation; Muscle Fibers, Skeletal; Oximes; Phenylcarbamates; Protein Binding; Proteome; Proteomics; Staining and Labeling; Ubiquitin; Ubiquitination | 2015 |
O-GlcNAc regulates NEDD4-1 stability via caspase-mediated pathway.
Topics: Acetylglucosamine; Acylation; Caspases; Endosomal Sorting Complexes Required for Transport; Enzyme Stability; Gene Knockout Techniques; HEK293 Cells; Humans; MCF-7 Cells; Metabolic Networks and Pathways; Mutation; N-Acetylglucosaminyltransferases; Nedd4 Ubiquitin Protein Ligases; Oximes; Phenylcarbamates; Ubiquitin-Protein Ligases; Ubiquitination | 2016 |
Dissecting PUGNAc-mediated inhibition of the pro-survival action of insulin.
Topics: Acetylglucosamine; Animals; Apoptosis; beta-N-Acetylhexosaminidases; Cells, Cultured; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Enzyme Inhibitors; Insulin; Insulin Resistance; Oximes; Phenylcarbamates; Structure-Activity Relationship | 2016 |
O-GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity.
Topics: Acetylglucosamine; Animals; Autophagy; Autophagy-Related Proteins; beta-N-Acetylhexosaminidases; Cell Line, Tumor; Cysteine Endopeptidases; Down-Regulation; Fibroblasts; Fluorescent Dyes; Gene Expression Regulation, Enzymologic; Glucose; Humans; Immunoprecipitation; Luciferases; Mass Spectrometry; Mice; Mixed Function Oxygenases; N-Acetylglucosaminyltransferases; Oximes; Phenylcarbamates; Signal Transduction | 2016 |
Synergistic activity of fosfomycin, β-lactams and peptidoglycan recycling inhibition against Pseudomonas aeruginosa.
Topics: Acetylglucosamine; Anti-Bacterial Agents; Cell Wall; Drug Synergism; Fosfomycin; Gene Deletion; Imipenem; Microbial Sensitivity Tests; Oximes; Peptidoglycan; Phenylcarbamates; Pseudomonas aeruginosa | 2017 |
Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance.
Topics: Acetylglucosamine; beta-Lactam Resistance; Escherichia coli; Escherichia coli Proteins; Glycoside Hydrolases; Oximes; Phenylcarbamates; Protein Domains; Protein Structure, Secondary | 2017 |
PUGNAc treatment provokes globotetraosylceramide accumulation in human umbilical vein endothelial cells.
Topics: Acetylglucosamine; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Globosides; Humans; Mice; Mice, Inbred C3H; Oximes; Phenylcarbamates; Umbilical Veins; Up-Regulation | 2017 |
Nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) is regulated by O-GlcNAc transferase.
Topics: Acetylglucosamine; Amino Acid Sequence; Binding Sites; Cloning, Molecular; Gene Expression; Glycosylation; HEK293 Cells; Host Cell Factor C1; Humans; N-Acetylglucosaminyltransferases; Nuclear Respiratory Factor 1; Oximes; Phenylcarbamates; Plasmids; Protein Binding; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Protein Stability; Proteolysis; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Transcriptional Activation; Transfection; Ubiquitination | 2017 |
O-GlcNAc Signaling Augmentation Protects Human Corneal Endothelial Cells from Oxidative Stress via AKT Pathway Activation.
Topics: Acetylglucosamine; Apoptosis; Blotting, Western; Calcium; Cell Survival; Cells, Cultured; Cytoplasm; Cytoprotection; Endothelium, Corneal; Humans; Membrane Potential, Mitochondrial; Mitochondria; Oxidative Stress; Oximes; Phenylcarbamates; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; tert-Butylhydroperoxide | 2020 |
Glucosamine regulates hepatic lipid accumulation by sensing glucose levels or feeding states of normal and excess.
Topics: Acetylglucosamine; Alloxan; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Glucosamine; Glucose; Hep G2 Cells; Humans; Lipids; Lipogenesis; Liver; N-Acetylglucosaminyltransferases; Oximes; Phenylcarbamates; Phosphorylation; Protein Kinases; Ribonucleotides; Sterol Regulatory Element Binding Protein 1; Zebrafish; Zebrafish Proteins | 2020 |
Role of the O-GlcNAc modification on insulin resistance and endoplasmic reticulum stress in 3T3-L1 cells.
Topics: 3T3-L1 Cells; Acetylglucosamine; Adipocytes; Animals; beta-N-Acetylhexosaminidases; Drug Resistance; Endoplasmic Reticulum Stress; Glucosamine; Glycolysis; Hexosamines; Insulin Resistance; Mice; N-Acetylglucosaminyltransferases; Oximes; Phenylcarbamates; Protein Processing, Post-Translational; RNA Interference; RNA, Small Interfering; Signal Transduction; Tunicamycin; Unfolded Protein Response | 2020 |