Page last updated: 2024-08-25

n-acetylcysteinamide and acetylcysteine

n-acetylcysteinamide has been researched along with acetylcysteine in 62 studies

Research

Studies (62)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	18 (29.03)	29.6817
2010's	35 (56.45)	24.3611
2020's	9 (14.52)	2.80

Authors

Authors	Studies
Atlas, D; Barhum, Y; Benhar, M; Gilgun-Sherki, Y; Grinberg, L; Melamed, E; Offen, D; Reich, R	1
Amer, J; Atlas, D; Fibach, E; Grinberg, L	1
Galdor, M; Maayan, R; Ram, E; Touati-Werner, D; Weizman, A	1
Atlas, D; Barhum, Y; Gilgun-Sherki, Y; Melamed, E; Offen, D	1
Banks, WA; Ercal, N; Goldstein, G; Mare, S; Penugonda, S	1
Atlas, D; Bartov, O; Butterfield, DA; Sultana, R	1
Banks, WA; Ercal, N; Price, TO; Uras, F	1
Banks, WA; Ercal, N; Lutz, P; Mare, S; Penugonda, S	1
Bujo, H; Imaizumi, T; Saito, Y; Takeuchi, M; Unoki, H; Yamagishi, S	1
Dithmar, S; Schütt, F; Völcker, HE	1
Amer, J; Atlas, D; Fibach, E	1
Atlas, D; Choe, YH; Han, HJ; Hong, SH; Kim, JS; Kim, SR; Lee, KS; Lee, KY; Lee, YC; Lee, YR; Min, KH; Park, HS; Park, SJ	1
Abraham, L; Ates, B; Ercal, N	1
Abraham, L; Ercal, N; Goldstein, G; Matthews, R; Ogony, J; Wu, W	1
Adeeb, S; Ahlers, ST; Chavko, M; McCarron, RM	1
Knight, JW; Whitaker, BD	1
Aronstam, RS; Ercal, N; Huang, CC; Huang, YW; Martin, A; Shi, R	1
Banerjee, A; Banks, WA; Ercal, N; Zhang, X	1
Banerjee, A; Ercal, N; Hagen, DE; Lobo, P; Manda, KR; Trueblood, MB; Whitefield, PD; Zhang, X	1
Carlsson, K; Celsi, G; Chen, M; Gong, X; Norgren, S	1
Banerjee, A; Banks, WA; Ercal, N; Manda, KR; Zhang, X	1
Campbell, KS; Ferreira, LF; Reid, MB	1
Ercal, N; Penugonda, S	1
Carey, JW; Ercal, N; Karacal, H; Penugonda, S; Pinarci, EY	1
Banerjee, A; Banks, WA; Ercal, N; Manda, KR	1
Abraham, L; Apte, RS; Cox, D; Dace, DS; Ercal, N; Kraus, C; Schimel, AM; Sene, A	1
Chen, W; Chusuei, CC; Ercal, N; Huynh, T; Volkov, A	1
Ercal, N; Tobwala, S; Zhang, X	1
Carlsson, K; Celsi, G; Gong, X; Norgren, S	1
Girish, KS; Hemshekhar, M; Kemparaju, K; Santhosh, MS; Sunitha, K; Thushara, RM; Yariswamy, M	1
Ercal, N; Fan, W; Stoeger, T; Tobwala, S	1
Ahmed, AU; Auffinger, B; Kim, CK; Lesniak, MS; Moon, KS; Tobias, AL; Ulasov, IV	1
Atabek Yigit, E; Ercal, N	1
Congdon, KL; Sampson, JH	1
Goldstein, GA; Pandya, JD; Patel, SP; Pauly, JR; Rabchevsky, AG; Readnower, RD; Sullivan, PG; Yonutas, HM	1
Eldahan, KC; Goldstein, GA; Magnuson, DS; Morehouse, J; Pandya, JD; Patel, SP; Rabchevsky, AG; Sullivan, PG; VanRooyen, JL; Yonutas, HM	1
Buck, LT; Dukoff, DJ; Hawrysh, PJ; Hogg, DW	1
Ercal, N; Fan, W; Khayyat, A; Tobwala, S	1
Devaraja, S; Girish, KS; Hemshekhar, M; Kemparaju, K; Nagaraju, G; Naveen, S; NaveenKumar, SK; Nayaka, SC; Paul, M; Rangappa, KS; Somyajit, K; Sundaram, MS; Thushara, RM; West, R; Zakai, UI	1
Davidsson, J; Günther, M; Mathiesen, T; Norgren, S; Plantman, S; Risling, M	1
Arimon, M; Berezovska, O; Hyman, BT; Post, KL; Svirsky, S; Takeda, S	1
Ercal, N; Hart, M; Khayyat, A; Tobwala, S	1
Carver, KA; Yang, D	1
Alhan, E; Cekic, AB; Ercin, C; Kural, BV; Turkyilmaz, S; Usta, A	1
Atlas, D; Filip, M; Frankowska, M; Jastrzębska, J	1
Ahmed, MS; Alfaro-Cervello, C; Baumbusch, LO; Benterud, T; Bjørås, M; Florholmen, G; Manueldas, S; Norgren, S; Pankratov, L; Sandvik, L; Saugstad, OD; Solberg, R; Ystgaard, MB	1
Best, R; Bews, H; Bhindi, R; Chaudhary, R; Cheung, D; Goyal, V; Jassal, DS; Mandal, S; Niraula, S; Premecz, S; Ravandi, A; Shaikh, B; Singal, PK; Thliveris, J	1
Duan, Y; Gong, X; Hei, TK; Norgren, S; Wang, G; Wang, Y; Zheng, J	1
Ercal, N; Karacal, H; Maddirala, Y; Tobwala, S	1
Baumbusch, LO; Benterud, T; Henckel, E; Løberg, EM; Manueldas, S; Norgren, S; Rivera, S; Saugstad, OD; Solberg, R	1
Huang, J; Li, J; Li, Q; Li, SB; Li, Z; Lu, G; Sham, PC; Wong, N; Yang, G; Zeng, XF	1
King, B; Shoup, R; Vance, J; Wall, GM	1
Aridon, P; Casari, G; Cittaro, D; De Fusco, M; Fischer, B; Guerrini, R; Lee, WT; Lubarr, N; Lüthy, K; Mackenzie, KM; Mei, D; Meijer, IA; Paesmans, J; Parrini, E; Schoovaerts, N; Swerts, J; Versées, W; Verstreken, P	1
Ginman, T; Hassan, M; He, R; Norgren, S; Ottosson, H; Zhao, Y; Zheng, W	1
Benvenutti, R; Elisabetsky, E; Herrmann, AP; Marcon, M; Mocelin, R; Piato, A; Reis, CG; Sachett, A	1
Bindoff, LA; Chen, A; Glover, JC; Ievglevskyi, O; Kondratskaya, E; Kristiansen, CK; Liang, KX; Sullivan, GJ; Vatne, GH	1
Benčina, M; Bergant, V; Govednik, T; Grass, V; Hafner-Bratkovič, I; Jazbec, V; Jerala, R; Lainšček, D; Manček-Keber, M; Orehek, S; Pichlmair, A; Plaper, T	1
Herland, A; Matthiesen, I; Nikolakopoulou, P; Voulgaris, D; Winkler, TE	1
Atlas, D	1
Kim, UJ; Lee, KH	1
Alkandari, AF; Madhyastha, S; Rao, MS	1
Abgharmi, BA; Charkhian, H; Ebrahimi, V; Fayyazi, F; Gholinejad, Z; Mamaghani, MM; Mosarrezaii, A; Zarrini, G	1

Reviews

2 review(s) available for n-acetylcysteinamide and acetylcysteine

Article	Year
N-Acetylcysteine amide: a derivative to fulfill the promises of N-Acetylcysteine. Free radical research, 2013, Volume: 47, Issue:5 Topics: Acetylcysteine; Antioxidants; Apoptosis; Cell Survival; Drug Therapy; Glutathione; Humans; Oxidative Stress; Reactive Oxygen Species	2013
Emerging therapeutic opportunities of novel thiol-amides, NAC-amide (AD4/NACA) and thioredoxin mimetics (TXM-Peptides) for neurodegenerative-related disorders. Free radical biology & medicine, 2021, 11-20, Volume: 176 Topics: Acetylcysteine; Amides; Humans; Neurodegenerative Diseases; Peptides; Sulfhydryl Compounds; Thioredoxins	2021

Trials

2 trial(s) available for n-acetylcysteinamide and acetylcysteine

Article	Year
N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI. Experimental neurology, 2014, Volume: 257 Topics: Acetylcysteine; Aldehydes; Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Double-Blind Method; Energy Metabolism; Glutathione; Male; Maze Learning; Mitochondria; Neuroprotective Agents; Oxidative Stress; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine	2014
N-acetylcysteine amide preserves mitochondrial bioenergetics and improves functional recovery following spinal trauma. Experimental neurology, 2014, Volume: 257 Topics: Acetylcysteine; Animals; Disease Models, Animal; Double-Blind Method; Drug Delivery Systems; Electron Transport Chain Complex Proteins; Energy Metabolism; Female; Ganglia, Spinal; Lameness, Animal; Mitochondria; Motor Activity; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord; Spinal Cord Injuries; Synapses; Time Factors	2014

Article

Year

N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI.

Experimental neurology, 2014, Volume: 257

Topics: Acetylcysteine; Aldehydes; Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Double-Blind Method; Energy Metabolism; Glutathione; Male; Maze Learning; Mitochondria; Neuroprotective Agents; Oxidative Stress; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine

2014

N-acetylcysteine amide preserves mitochondrial bioenergetics and improves functional recovery following spinal trauma.

Experimental neurology, 2014, Volume: 257

Topics: Acetylcysteine; Animals; Disease Models, Animal; Double-Blind Method; Drug Delivery Systems; Electron Transport Chain Complex Proteins; Energy Metabolism; Female; Ganglia, Spinal; Lameness, Animal; Mitochondria; Motor Activity; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord; Spinal Cord Injuries; Synapses; Time Factors

2014

Other Studies

58 other study(ies) available for n-acetylcysteinamide and acetylcysteine

Article	Year
A low molecular weight copper chelator crosses the blood-brain barrier and attenuates experimental autoimmune encephalomyelitis. Journal of neurochemistry, 2004, Volume: 89, Issue:5 Topics: Acetylcysteine; Administration, Oral; Animals; Antimetabolites, Antineoplastic; Biological Transport; Blood-Brain Barrier; Cell Line; Cell Membrane Permeability; Chelating Agents; Copper; Disease Models, Animal; Drug Evaluation, Preclinical; Encephalomyelitis, Autoimmune, Experimental; Erythrocytes; Female; Humans; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinases; Molecular Weight; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Reactive Oxygen Species; Sulfhydryl Compounds; Treatment Outcome	2004
N-acetylcysteine amide, a novel cell-permeating thiol, restores cellular glutathione and protects human red blood cells from oxidative stress. Free radical biology & medicine, 2005, Jan-01, Volume: 38, Issue:1 Topics: Acetylcysteine; Cell Membrane; Cell Membrane Permeability; Erythrocytes; Glutathione; Hemoglobins; Humans; Oxidation-Reduction; Oxidative Stress; tert-Butylhydroperoxide	2005
Is brain dehydroepiandrosterone synthesis modulated by free radicals in mice? Neuroscience letters, 2005, Mar-29, Volume: 377, Issue:2 Topics: Acetylcysteine; Animals; Brain; Dehydroepiandrosterone; Free Radicals; Male; Mice; Mice, Inbred ICR; Orchiectomy	2005
Analysis of gene expression in MOG-induced experimental autoimmune encephalomyelitis after treatment with a novel brain-penetrating antioxidant. Journal of molecular neuroscience : MN, 2005, Volume: 27, Issue:1 Topics: Acetylcysteine; Animals; Antioxidants; Brain; Encephalomyelitis, Autoimmune, Experimental; Gene Expression; Gene Expression Profiling; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Proteins; Myelin-Associated Glycoprotein; Myelin-Oligodendrocyte Glycoprotein; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Reactive Oxygen Species; Spinal Cord	2005
Effects of N-acetylcysteine amide (NACA), a novel thiol antioxidant against glutamate-induced cytotoxicity in neuronal cell line PC12. Brain research, 2005, Sep-21, Volume: 1056, Issue:2 Topics: Acetylcysteine; Animals; Antioxidants; Cell Survival; Drug Interactions; Glutamic Acid; L-Lactate Dehydrogenase; Lipid Peroxidation; Malondialdehyde; PC12 Cells; Rats; Reactive Oxygen Species; Tetrazolium Salts	2005
Low molecular weight thiol amides attenuate MAPK activity and protect primary neurons from Abeta(1-42) toxicity. Brain research, 2006, Jan-19, Volume: 1069, Issue:1 Topics: Acetylcysteine; Amides; Amyloid beta-Peptides; Animals; Animals, Newborn; Blotting, Western; Cells, Cultured; Cerebral Cortex; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Free Radical Scavengers; Glutathione; Lipid Peroxidation; Mice; Mitogen-Activated Protein Kinase Kinases; Molecular Weight; Neurons; Oligopeptides; Oxidation-Reduction; Peptide Fragments; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles; Tyrosine	2006
A novel antioxidant N-acetylcysteine amide prevents gp120- and Tat-induced oxidative stress in brain endothelial cells. Experimental neurology, 2006, Volume: 201, Issue:1 Topics: Acetylcysteine; Animals; Brain; Caspase 3; Caspases; Catalase; Cell Line; Cell Survival; Endothelial Cells; Gene Products, tat; Glutathione; Glutathione Disulfide; Glutathione Reductase; HIV Envelope Protein gp120; Intracellular Fluid; Malondialdehyde; Molecular Structure; Oxidative Stress; Rats; Reactive Oxygen Species	2006
Potentiation of lead-induced cell death in PC12 cells by glutamate: protection by N-acetylcysteine amide (NACA), a novel thiol antioxidant. Toxicology and applied pharmacology, 2006, Oct-15, Volume: 216, Issue:2 Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Calcium Channel Blockers; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Environmental Pollutants; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutathione; Lead; Lead Poisoning; Oxidative Stress; PC12 Cells; Phospholipases A; Protein Kinase C; Rats; Reactive Oxygen Species	2006
Advanced glycation end products attenuate cellular insulin sensitivity by increasing the generation of intracellular reactive oxygen species in adipocytes. Diabetes research and clinical practice, 2007, Volume: 76, Issue:2 Topics: 3T3-L1 Cells; Acetylcysteine; Adipocytes; Animals; Biological Transport; Blotting, Western; Cell Differentiation; Chemokine CCL2; Deoxyglucose; Dose-Response Relationship, Drug; Gene Expression; Glucose; Glycation End Products, Advanced; Glyceraldehyde; Insulin; Mice; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; Time Factors	2007
[N-acetylcysteine improves lysosomal function and enhances the degradation of photoreceptor outer segments in cultured RPE cells]. Klinische Monatsblatter fur Augenheilkunde, 2007, Volume: 224, Issue:7 Topics: Acetylcysteine; Antioxidants; Cells, Cultured; Fluorescence; Humans; Lipid Peroxidation; Lipofuscin; Lysosomes; Methylamines; Pigment Epithelium of Eye; Proteins; Proteomics; Rod Cell Outer Segment	2007
N-acetylcysteine amide (AD4) attenuates oxidative stress in beta-thalassemia blood cells. Biochimica et biophysica acta, 2008, Volume: 1780, Issue:2 Topics: Acetylcysteine; Animals; beta-Thalassemia; Blood Cells; Female; Free Radical Scavengers; Glutathione; Hemolysis; Humans; Male; Mice; Oxidative Stress; Phagocytosis	2008
A novel thiol compound, N-acetylcysteine amide, attenuates allergic airway disease by regulating activation of NF-kappaB and hypoxia-inducible factor-1alpha. Experimental & molecular medicine, 2007, Dec-31, Volume: 39, Issue:6 Topics: Acetylcysteine; Animals; Asthma; Bronchial Hyperreactivity; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; NF-kappa B; Ovalbumin; Reactive Oxygen Species; Vascular Endothelial Growth Factor A	2007
Antioxidant and free radical scavenging properties of N-acetylcysteine amide (NACA) and comparison with N-acetylcysteine (NAC). Free radical research, 2008, Volume: 42, Issue:4 Topics: Acetylcysteine; Antioxidants; beta Carotene; Biphenyl Compounds; Chelating Agents; Dose-Response Relationship, Drug; Edetic Acid; Free Radical Scavengers; Free Radicals; Humans; Hydrazines; Hydrogen Peroxide; Linoleic Acid; Metals; Picrates; Sulfhydryl Compounds	2008
Effects of N-acetylcysteine amide (NACA), a thiol antioxidant on radiation-induced cytotoxicity in Chinese hamster ovary cells. Life sciences, 2008, May-23, Volume: 82, Issue:21-22 Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Caspase 3; Catalase; Cell Proliferation; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Cysteine; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Malondialdehyde; Oxidative Stress; Radiation-Protective Agents	2008
Attenuation of pulmonary inflammation after exposure to blast overpressure by N-acetylcysteine amide. Shock (Augusta, Ga.), 2009, Volume: 32, Issue:3 Topics: Acetylcysteine; Animals; Antioxidants; CD11b Antigen; Chemokine CCL2; Chemokine CXCL1; Glutathione Reductase; Heme Oxygenase-1; Lung Injury; Macrophage Inflammatory Proteins; Male; Neutrophil Infiltration; Peroxidase; Pneumonia; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Superoxide Dismutase	2009
Effects of N-acetyl-cysteine and N-acetyl-cysteine-amide supplementation on in vitro matured porcine oocytes. Reproduction in domestic animals = Zuchthygiene, 2010, Volume: 45, Issue:5 Topics: Acetylcysteine; Animals; Culture Media; Dose-Response Relationship, Drug; Embryo Culture Techniques; Embryonic Development; Female; Fertilization in Vitro; Oocytes; Swine	2010
N-acetylcysteine amide decreases oxidative stress but not cell death induced by doxorubicin in H9c2 cardiomyocytes. BMC pharmacology, 2009, Apr-15, Volume: 9 Topics: Acetylcysteine; Animals; Antibiotics, Antineoplastic; Catalase; Cell Line; Cell Survival; Cysteine; Dose-Response Relationship, Drug; Doxorubicin; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Reductase; Lipid Peroxidation; Myocytes, Cardiac; Oxidative Stress; Reactive Oxygen Species; Time Factors	2009
N-Acetylcysteine amide protects against methamphetamine-induced oxidative stress and neurotoxicity in immortalized human brain endothelial cells. Brain research, 2009, Jun-12, Volume: 1275 Topics: Acetylcysteine; Brain; Cell Line, Transformed; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Humans; Methamphetamine; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species	2009
N-acetylcysteineamide (NACA) prevents inflammation and oxidative stress in animals exposed to diesel engine exhaust. Toxicology letters, 2009, Jun-22, Volume: 187, Issue:3 Topics: Acetylcysteine; Animals; Antioxidants; Catalase; Cysteine; Glutathione; Histocytochemistry; L-Lactate Dehydrogenase; Macrophages, Alveolar; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Oxidative Stress; Pneumonia; Vehicle Emissions	2009
N-acetylcysteine amide protects renal proximal tubular epithelial cells against iohexol-induced apoptosis by blocking p38 MAPK and iNOS signaling. American journal of nephrology, 2010, Volume: 31, Issue:2 Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Cell Separation; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression Regulation; Humans; Iohexol; Kidney; Kidney Tubules; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Swine	2010
HIV proteins (gp120 and Tat) and methamphetamine in oxidative stress-induced damage in the brain: potential role of the thiol antioxidant N-acetylcysteine amide. Free radical biology & medicine, 2010, May-15, Volume: 48, Issue:10 Topics: Acetylcysteine; AIDS Dementia Complex; Animals; Antioxidants; Blood-Brain Barrier; Brain; Glutathione Disulfide; HIV Envelope Protein gp120; HIV Infections; HIV-1; Humans; Illicit Drugs; Malondialdehyde; Methamphetamine; Mice; Mice, Inbred Strains; Oxidative Stress; Risk Factors; tat Gene Products, Human Immunodeficiency Virus; Tight Junctions	2010
Effectiveness of sulfur-containing antioxidants in delaying skeletal muscle fatigue. Medicine and science in sports and exercise, 2011, Volume: 43, Issue:6 Topics: Acetylcysteine; Animals; Antioxidants; Diaphragm; Ergothioneine; Mice; Mice, Inbred C57BL; Muscle Fatigue; Muscle Relaxation	2011
Comparative evaluation of N-acetylcysteine (NAC) and N-acetylcysteine amide (NACA) on glutamate and lead-induced toxicity in CD-1 mice. Toxicology letters, 2011, Feb-25, Volume: 201, Issue:1 Topics: Acetylcysteine; Animals; Antioxidants; Chelating Agents; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Glutathione; Glutathione Disulfide; Lead; Male; Malondialdehyde; Mice; Phospholipases A2; Reactive Oxygen Species	2011
In vivo inhibition of l-buthionine-(S,R)-sulfoximine-induced cataracts by a novel antioxidant, N-acetylcysteine amide. Free radical biology & medicine, 2011, Mar-15, Volume: 50, Issue:6 Topics: Acetylcysteine; Animals; Antioxidants; Buthionine Sulfoximine; Catalase; Cataract; Female; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Lens, Crystalline; Male; Malondialdehyde; Oxidative Stress; Protein Carbonylation; Rats; Rats, Wistar	2011
Highly active antiretroviral therapy drug combination induces oxidative stress and mitochondrial dysfunction in immortalized human blood-brain barrier endothelial cells. Free radical biology & medicine, 2011, Apr-01, Volume: 50, Issue:7 Topics: Acetylcysteine; Adenosine Triphosphate; Antiretroviral Therapy, Highly Active; Apoptosis; Blood-Brain Barrier; Caspase 3; Cell Line, Transformed; Cytochromes c; Endothelial Cells; Glutathione; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Malondialdehyde; Membrane Potential, Mitochondrial; Mitochondria; Oxidative Stress; Reactive Oxygen Species; Zidovudine	2011
N-acetylcysteine amide (NACA) prevents retinal degeneration by up-regulating reduced glutathione production and reversing lipid peroxidation. The American journal of pathology, 2011, Volume: 178, Issue:5 Topics: Acetylcysteine; Animals; Antioxidants; Cells, Cultured; Free Radical Scavengers; Glutathione; Humans; Lipid Peroxidation; Mice; Oxidative Stress; Retinal Degeneration; Retinal Pigment Epithelium	2011
Characterizing N-acetylcysteine (NAC) and N-acetylcysteine amide (NACA) binding for lead poisoning treatment. Journal of colloid and interface science, 2012, Apr-01, Volume: 371, Issue:1 Topics: Acetylcysteine; Chromatography, High Pressure Liquid; Free Radical Scavengers; Lead; Lead Poisoning; Photoelectron Spectroscopy; Spectrometry, Mass, Electrospray Ionization	2012
N-acetylcysteine amide protects against methamphetamine-induced tissue damage in CD-1 mice. Human & experimental toxicology, 2012, Volume: 31, Issue:9 Topics: Acetylcysteine; Animals; Antioxidants; Brain; Catalase; Central Nervous System Stimulants; Glutathione; Glutathione Peroxidase; Kidney; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methamphetamine; Mice; Oxidative Stress; Protein Carbonylation	2012
Protective effects of N-acetylcysteine amide (NACA) on gentamicin-induced apoptosis in LLC-PK1 cells. Renal failure, 2012, Volume: 34, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cell Survival; Cells, Cultured; Disease Models, Animal; DNA; Flow Cytometry; Free Radical Scavengers; Gene Expression Regulation; Gentamicins; LLC-PK1 Cells; NF-kappa B; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Polymerase Chain Reaction; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Swine	2012
N-acetylcysteine amide, a thiol antioxidant, prevents bleomycin-induced toxicity in human alveolar basal epithelial cells (A549). Free radical research, 2013, Volume: 47, Issue:9 Topics: Acetylcysteine; Alveolar Epithelial Cells; Antioxidants; Bleomycin; Cell Line; Cell Survival; Epithelial Cells; Glutathione; Humans; Lipid Peroxidation; Lung; Oxidative Stress; Reactive Oxygen Species	2013
N-acetylcysteine amide augments the therapeutic effect of neural stem cell-based antiglioma oncolytic virotherapy. Molecular therapy : the journal of the American Society of Gene Therapy, 2013, Volume: 21, Issue:11 Topics: Acetylcysteine; Adenoviridae; Animals; Cell Line, Tumor; Glioma; Mice; Mice, Nude; Molecular Targeted Therapy; Neoplasms, Experimental; Neural Stem Cells; Oncolytic Virotherapy; Oncolytic Viruses; Virus Replication; Xenograft Model Antitumor Assays	2013
Release of N-acetylcysteine and N-acetylcysteine amide from contact lenses. Eye & contact lens, 2013, Volume: 39, Issue:5 Topics: Acetylcysteine; Antioxidants; Chromatography, High Pressure Liquid; Contact Lenses, Hydrophilic; Drug Delivery Systems; Free Radical Scavengers	2013
Enhanced oncolytic virotherapy through oxidative stress inhibition. Molecular therapy : the journal of the American Society of Gene Therapy, 2013, Volume: 21, Issue:11 Topics: Acetylcysteine; Adenoviridae; Animals; Glioma; Neural Stem Cells; Oncolytic Virotherapy	2013
Scavenging ROS dramatically increase NMDA receptor whole-cell currents in painted turtle cortical neurons. The Journal of experimental biology, 2014, Sep-15, Volume: 217, Issue:Pt 18 Topics: Acetylcysteine; Animals; Calcium; Cerebral Cortex; Female; Free Radical Scavengers; Hydrogen Peroxide; Membrane Potentials; Mitochondria; Neurons; Oxygen; Patch-Clamp Techniques; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Rotenone; Tiopronin; Turtles	2014
Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells. Experimental biology and medicine (Maywood, N.J.), 2015, Volume: 240, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Overdose; Free Radical Scavengers; Humans; Lipid Peroxidation; Liver Neoplasms; Mitochondria, Liver; Oxidative Stress; Reactive Oxygen Species	2015
Methotrexate Promotes Platelet Apoptosis via JNK-Mediated Mitochondrial Damage: Alleviation by N-Acetylcysteine and N-Acetylcysteine Amide. PloS one, 2015, Volume: 10, Issue:6 Topics: Acetylcysteine; Antimetabolites, Antineoplastic; Antioxidants; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; BH3 Interacting Domain Death Agonist Protein; Blood Platelets; Gene Expression Regulation; Humans; MAP Kinase Kinase 4; Membrane Potential, Mitochondrial; Methotrexate; Mitochondria; Oxidation-Reduction; Oxidative Stress; Phosphorylation; Primary Cell Culture; Signal Transduction	2015
Neuroprotective effects of N-acetylcysteine amide on experimental focal penetrating brain injury in rats. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2015, Volume: 22, Issue:9 Topics: Acetylcysteine; Animals; Apoptosis; Brain; Brain Injuries; Head Injuries, Penetrating; In Situ Nick-End Labeling; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley	2015
Oxidative stress and lipid peroxidation are upstream of amyloid pathology. Neurobiology of disease, 2015, Volume: 84 Topics: Acetylcysteine; Aldehydes; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Antioxidants; Brain; Disulfides; Lipid Peroxidation; Membrane Glycoproteins; Mice; Oxidative Stress; Peptide Fragments; Presenilin-1; Pyridines	2015
N-acetylcysteine amide, a promising antidote for acetaminophen toxicity. Toxicology letters, 2016, Jan-22, Volume: 241 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antidotes; Antioxidants; Chemical and Drug Induced Liver Injury; Glutamate Dehydrogenase; Glutathione; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Oxidative Stress; Survival Analysis	2016
N-Acetylcysteine Amide Protects Against Oxidative Stress-Induced Microparticle Release From Human Retinal Pigment Epithelial Cells. Investigative ophthalmology & visual science, 2016, Volume: 57, Issue:2 Topics: Acetylcysteine; Blotting, Western; CD55 Antigens; CD59 Antigens; Cell-Derived Microparticles; Cells, Cultured; Flow Cytometry; Humans; Hydrogen Peroxide; Male; Membrane Cofactor Protein; Microscopy, Confocal; Microscopy, Electron, Transmission; Middle Aged; Oxidants; Oxidative Stress; Retinal Pigment Epithelium	2016
N-acetylcysteine amid reduces pancreatic damage in a rat model of acute necrotizing pancreatitis. The Journal of surgical research, 2016, 06-15, Volume: 203, Issue:2 Topics: Acetylcysteine; Animals; Antioxidants; Biomarkers; Ceruletide; Hemodynamics; Kidney; Liver; Male; Pancreas; Pancreatitis, Acute Necrotizing; Random Allocation; Rats; Rats, Sprague-Dawley; Treatment Outcome	2016
N-acetylcysteine amide (AD4) reduces cocaine-induced reinstatement. Psychopharmacology, 2016, Volume: 233, Issue:18 Topics: Acetylcysteine; Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Cues; Depression; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Extinction, Psychological; Male; Olfactory Bulb; Rats; Rats, Wistar; Reward; Self Administration	2016
N-Acetylcysteine Amide Exerts Possible Neuroprotective Effects in Newborn Pigs after Perinatal Asphyxia. Neonatology, 2017, Volume: 111, Issue:1 Topics: Acetylcysteine; Animals; Animals, Newborn; Asphyxia Neonatorum; Biomarkers; Brain; Female; Hypoxia; Interleukin-1beta; Male; Neuroprotective Agents; NF-kappa B; Oxygen; Swine; Time Factors; Tumor Necrosis Factor-alpha	2017
The Cardioprotective Role of N-Acetyl Cysteine Amide in the Prevention of Doxorubicin and Trastuzumab-Mediated Cardiac Dysfunction. The Canadian journal of cardiology, 2016, Volume: 32, Issue:12 Topics: Acetylcysteine; Animals; Antineoplastic Agents; Antioxidants; Cardiotonic Agents; Cardiotoxicity; Disease Models, Animal; Doxorubicin; Drug Monitoring; Echocardiography; Female; Mice; Oxidative Stress; Trastuzumab; Treatment Outcome	2016
Nephroprotective Effects of N-Acetylcysteine Amide against Contrast-Induced Nephropathy through Upregulating Thioredoxin-1, Inhibiting ASK1/p38MAPK Pathway, and Suppressing Oxidative Stress and Apoptosis in Rats. Oxidative medicine and cellular longevity, 2016, Volume: 2016 Topics: Acetylcysteine; Acute Kidney Injury; Animals; Apoptosis; Contrast Media; Kidney; Male; MAP Kinase Kinase Kinase 5; Microscopy, Electron, Transmission; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protective Agents; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxide Dismutase; Thioredoxins; Up-Regulation	2016
Prevention and reversal of selenite-induced cataracts by N-acetylcysteine amide in Wistar rats. BMC ophthalmology, 2017, Apr-26, Volume: 17, Issue:1 Topics: Acetylcysteine; Animals; Blotting, Western; Cataract; Disease Models, Animal; Lens, Crystalline; Male; Ophthalmic Solutions; Oxidative Stress; Rats; Rats, Wistar; Selenious Acid	2017
Cerebellum Susceptibility to Neonatal Asphyxia: Possible Protective Effects of N-Acetylcysteine Amide. Disease markers, 2018, Volume: 2018 Topics: Acetylcysteine; Animals; Asphyxia Neonatorum; Disease Models, Animal; DNA, Mitochondrial; Humans; Infant, Newborn; Mutation Rate; Neuroprotective Agents; Proteolysis; Purkinje Cells; Swine	2018
HIV-1 Tat and methamphetamine co-induced oxidative cellular injury is mitigated by N-acetylcysteine amide (NACA) through rectifying mTOR signaling. Toxicology letters, 2018, Dec-15, Volume: 299 Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Cell Line, Tumor; Cell Survival; Corpus Striatum; Dose-Response Relationship, Drug; Drug Synergism; Humans; Male; Methamphetamine; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction; tat Gene Products, Human Immunodeficiency Virus; TOR Serine-Threonine Kinases	2018
Quantitation of free and total N-acetylcysteine amide and its metabolite N-acetylcysteine in human plasma using derivatization and electrospray LC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2019, Mar-01, Volume: 1109 Topics: Acetylcysteine; Chromatography, High Pressure Liquid; Drug Stability; Humans; Limit of Detection; Linear Models; Reproducibility of Results; Tandem Mass Spectrometry	2019
TBC1D24-TLDc-related epilepsy exercise-induced dystonia: rescue by antioxidants in a disease model. Brain : a journal of neurology, 2019, 08-01, Volume: 142, Issue:8 Topics: Acetylcysteine; Adolescent; alpha-Tocopherol; Amino Acid Motifs; Amino Acid Sequence; Animals; Animals, Genetically Modified; Antioxidants; Biological Transport; Catalytic Domain; Child; Child, Preschool; Crystallography, X-Ray; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Dystonia; Epilepsy, Rolandic; Female; GTPase-Activating Proteins; Humans; Infant; Locomotion; Male; Models, Molecular; Mutation, Missense; Neurons; Oxidative Stress; Pedigree; Physical Exertion; Protein Conformation; rab GTP-Binding Proteins; Reactive Oxygen Species; Recombinant Proteins; Sequence Alignment; Sequence Deletion; Sequence Homology, Amino Acid; Synaptic Vesicles	2019
Pharmacokinetic profile of N-acetylcysteine amide and its main metabolite in mice using new analytical method. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2020, Feb-15, Volume: 143 Topics: Acetylcysteine; Animals; Biological Availability; Female; Glutathione; Humans; Mice, Inbred BALB C; Prodrugs; Sulfhydryl Compounds	2020
Effects of N-acetylcysteine amide on anxiety and stress behavior in zebrafish. Naunyn-Schmiedeberg's archives of pharmacology, 2020, Volume: 393, Issue:4 Topics: Acetylcysteine; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Female; Male; Oxidative Stress; Stress, Psychological; Zebrafish	2020
N-acetylcysteine amide ameliorates mitochondrial dysfunction and reduces oxidative stress in hiPSC-derived dopaminergic neurons with POLG mutation. Experimental neurology, 2021, Volume: 337 Topics: Acetylcysteine; Action Potentials; Antioxidants; Cellular Senescence; DNA Polymerase gamma; DNA, Mitochondrial; Dopaminergic Neurons; Electron Transport Complex I; Excitatory Postsynaptic Potentials; Humans; Induced Pluripotent Stem Cells; Membrane Potential, Mitochondrial; Mitochondrial Diseases; Oxidative Stress; Sodium Channels	2021
Disruption of disulfides within RBD of SARS-CoV-2 spike protein prevents fusion and represents a target for viral entry inhibition by registered drugs. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:6 Topics: Acetylcysteine; Amides; Ascorbic Acid; Auranofin; COVID-19; COVID-19 Drug Treatment; Disulfides; Esters; HEK293 Cells; Humans; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Sulfhydryl Compounds; Virus Internalization	2021
Continuous Monitoring Reveals Protective Effects of N-Acetylcysteine Amide on an Isogenic Microphysiological Model of the Neurovascular Unit. Small (Weinheim an der Bergstrasse, Germany), 2021, Volume: 17, Issue:32 Topics: Acetylcysteine; Blood-Brain Barrier; Cells, Cultured; Coculture Techniques; Humans; Induced Pluripotent Stem Cells	2021
Neuroprotective effects of N-acetylcysteine amide against oxidative injury in an aging model of organotypic hippocampal slice cultures. Neuroreport, 2022, 03-02, Volume: 33, Issue:4 Topics: Acetylcysteine; Aging; Animals; Hippocampus; Neuroprotective Agents; Oxidative Stress; Rats	2022
N-Acetylcysteine Amide against Aβ-Induced Alzheimer's-like Pathology in Rats. International journal of molecular sciences, 2023, Aug-12, Volume: 24, Issue:16 Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Gliosis; Glutathione; Male; Neuroprotective Agents; Rats; Rats, Wistar; Synaptophysin	2023
N-Acetyl cysteine amide and cerium oxide nanoparticles as a drug delivery for ischemic stroke treatment: Inflammation and oxidative stress crosstalk. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2023, Volume: 80 Topics: Acetylcysteine; Amides; Animals; Anti-Bacterial Agents; Antioxidants; Cerium; Chitinase-3-Like Protein 1; Drug Delivery Systems; Humans; Inflammation; Ischemic Stroke; Nanoparticles; Olive Oil; Oxidative Stress; Rats; Urea	2023