n-acetyl-4-benzoquinoneimine and cysteine

n-acetyl-4-benzoquinoneimine has been researched along with cysteine in 13 studies

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (15.38)	18.7374
1990's	4 (30.77)	18.2507
2000's	4 (30.77)	29.6817
2010's	3 (23.08)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Benson, RW; Hinson, JA; Pumford, NR; Roberts, DW	1
Chen, NQ; Goon, DJ; Holtzman, JL; Liu, YX; Prasad, JS	1
Baillie, TA; Dahlin, DC; Nelson, SD; Streeter, AJ	1
Corcoran, GB; Horning, EC; Mitchell, JR; Vaishnav, YN	1
Rommelspacher, H; Włodek, L	1
Chen, W; Gartner, C; Hunter, A; Nelson, SD; Shockcor, JP; Tonge, R	1
Commandeur, JN; Damsten, MC; Fidder, A; Hulst, AG; Noort, D; Touw, D; Vermeulen, NP	1
Boos, J; Hempel, G; Koling, S; Lanvers, C; Würthwein, G	1
Commandeur, JN; Damsten, MC; de Vlieger, JS; Hoos, JS; Irth, H; Lingeman, H; Niessen, WM; Vermeulen, NP	1
Boerma, JS; Dowdall, SM; Goldring, CE; Hamlett, J; Jenkins, RE; Kitteringham, NR; Lane, CS; Park, BK; Vermeulen, NP	1
Goto, T; Lee, SH; Oe, T; Osaki, F	1
de la Roche, J; Eberhardt, EM; Eberhardt, MJ; Echtermeyer, F; Herzog, C; Leffler, A; Risser, L; Schillers, F	1
Kubo, T; Lee, SH; Oe, T; Ozawa, M	1

Trials

1 trial(s) available for n-acetyl-4-benzoquinoneimine and cysteine

Article	Year
Monitoring paracetamol metabolism after single and repeated administration in pediatric patients with neoplastic diseases. International journal of clinical pharmacology and therapeutics, 2007, Volume: 45, Issue:9 Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Antineoplastic Agents; Benzoquinones; Child; Child, Preschool; Cysteine; Drug Administration Schedule; Drug Interactions; Humans; Imines; Infant; Neoplasms; Oxidation-Reduction	2007

Article

Year

Monitoring paracetamol metabolism after single and repeated administration in pediatric patients with neoplastic diseases.

International journal of clinical pharmacology and therapeutics, 2007, Volume: 45, Issue:9

Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Antineoplastic Agents; Benzoquinones; Child; Child, Preschool; Cysteine; Drug Administration Schedule; Drug Interactions; Humans; Imines; Infant; Neoplasms; Oxidation-Reduction

2007

Other Studies

12 other study(ies) available for n-acetyl-4-benzoquinoneimine and cysteine

Article	Year
Immunochemical quantitation of 3-(cystein-S-yl)acetaminophen protein adducts in subcellular liver fractions following a hepatotoxic dose of acetaminophen. Biochemical pharmacology, 1990, Aug-01, Volume: 40, Issue:3 Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Cell Membrane; Cell Nucleus; Chemical and Drug Induced Liver Injury; Cysteine; Cytosol; Fluorescent Antibody Technique; Imines; Kinetics; Liver; Male; Mice; Microsomes, Liver; Mitochondria, Liver; Quinones	1990
Effects of ethanol and inhibitors on the binding and metabolism of acetaminophen and N-acetyl-p-benzoquinone imine by hepatic microsomes from control and ethanol-treated rats. Biochemical pharmacology, 1990, Nov-01, Volume: 40, Issue:9 Topics: Acetaminophen; Alcoholism; Animals; Benzoquinones; Cysteine; Ethanol; Imines; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Inbred Strains	1990
The covalent binding of acetaminophen to protein. Evidence for cysteine residues as major sites of arylation in vitro. Chemico-biological interactions, 1984, Volume: 48, Issue:3 Topics: Acetaminophen; Amino Acids; Animals; Benzoquinones; Caseins; Cysteine; Glutathione; Imines; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; NADP; Phenobarbital; Proteins; Serum Albumin, Bovine	1984
Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine. Molecular pharmacology, 1980, Volume: 18, Issue:3 Topics: Acetaminophen; Animals; Ascorbic Acid; Benzoquinones; Cysteine; Imines; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Rats	1980
2-Methyl-thiazolidine-2,4-dicarboxylic acid protects against paracetamol induced toxicity in human liver derived HepG2 cells. Acta biochimica Polonica, 1997, Volume: 44, Issue:4 Topics: Acetaminophen; Antidotes; Benzoquinones; Cell Line; Cysteine; Glutathione; Humans; Imines; Liver; Malondialdehyde; Oxidation-Reduction; Prodrugs; Reactive Oxygen Species; Thiazoles; Thiazolidines	1997
Protein and nonprotein cysteinyl thiol modification by N-acetyl-p-benzoquinone imine via a novel ipso adduct. Biochemistry, 1999, Jun-22, Volume: 38, Issue:25 Topics: Acetaminophen; Ascorbic Acid; Benzoquinones; Cysteine; Glutathione; Half-Life; Imines; Macromolecular Substances; Papain; Proteins; Sulfhydryl Compounds	1999
Liquid chromatography/tandem mass spectrometry detection of covalent binding of acetaminophen to human serum albumin. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:8 Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Chromatography, Liquid; Cysteine; Humans; Imines; Microsomes, Liver; Models, Biological; Molecular Structure; Oligopeptides; Protein Binding; Rats; Reproducibility of Results; Serum Albumin; Tandem Mass Spectrometry	2007
Automated detection of covalent adducts to human serum albumin by immunoaffinity chromatography, on-line solution phase digestion and liquid chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Nov-15, Volume: 859, Issue:2 Topics: Automation; Benzoquinones; Chromatography, Affinity; Chromatography, Liquid; Cysteine; Dinitrochlorobenzene; Humans; Imines; Mass Spectrometry; Online Systems; Pronase; Serum Albumin	2007
Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites. Proteomics, 2008, Volume: 8, Issue:2 Topics: Acetaminophen; Amino Acid Sequence; Benzoquinones; Cells, Cultured; Cysteine; Glutathione S-Transferase pi; Humans; Imines; Models, Molecular; Molecular Sequence Data; Proteomics	2008
Predicted multiple selected reaction monitoring to screen activated drug-mediated modifications on human serum albumin. Analytical biochemistry, 2014, Mar-15, Volume: 449 Topics: Amino Acid Sequence; Benzoquinones; Binding Sites; Cysteine; Humans; Imines; Ketoprofen; Lysine; Mass Spectrometry; Molecular Sequence Data; Pharmaceutical Preparations; Protein Binding; Serum Albumin	2014
Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1. Scientific reports, 2017, 10-06, Volume: 7, Issue:1 Topics: Acetaminophen; Animals; Benzoquinones; Calcium; Capsaicin; Cell Death; Cysteine; Ganglia, Spinal; HEK293 Cells; Hepatocytes; Humans; Imines; Intracellular Space; Ion Channel Gating; Male; Metabolome; Mice, Inbred C57BL; Pain; Phosphorylation; Reducing Agents; Reflex; Regional Blood Flow; Skin; TRPV Cation Channels	2017
LC-MS analyses of N-acetyl-p-benzoquinone imine-adducts of glutathione, cysteine, N-acetylcysteine, and albumin in a plasma sample: A case study from a patient with a rare acetaminophen-induced acute swelling rash. The Journal of toxicological sciences, 2019, Volume: 44, Issue:8 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Benzoquinones; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cysteine; Edema; Exanthema; Glutathione; Humans; Imines; Male; Protein Binding; Serum Albumin; Skin Diseases; Tandem Mass Spectrometry	2019