Page last updated: 2024-08-23

n'-nitrosonornicotine and nicotine

n'-nitrosonornicotine has been researched along with nicotine in 81 studies

Research

Studies (81)

Timeframe	Studies, this research(%)	All Research%
pre-1990	31 (38.27)	18.7374
1990's	16 (19.75)	18.2507
2000's	10 (12.35)	29.6817
2010's	18 (22.22)	24.3611
2020's	6 (7.41)	2.80

Authors

Authors	Studies
Hecht, SS; Hoffmann, D; Ornaf, RM	1
Castonguay, A; Van Vunakins, H	1
Chen, CH; Fung, PT; Hecht, SS	1
Chen, CB; Hecht, SS; Hirota, N; Hoffmann, D; Ornaf, RM; Tso, TC	1
Hecht, SS; Hilfrich, J; Hoffmann, D	1
Dong, M; Hecht, SS; Hoffmann, D	1
Singer, GM; Taylor, HW	1
Gronowitz, JS; Hirsch, JM; Larsson, PA; Vahlne, A	1
Cherrick, HM; Dokko, H; Min, PS; Park, NH	1
Fischer, S; Preussmann, R; Spiegelhalder, B	1
Heiblum, R; Murphy, SE	1
Castonguay, A; Fischer, S; Kaiserman, M; Preussmann, R; Spiegelhalder, B	1
Osterdahl, BG	1
Eisenbarth, J; Fischer, S; Preussmann, R; Spiegelhalder, B	1
Castonguay, A; Desnoyers, S; Talbot, B	1
Adams, JD; Hoffmann, D; O'Mara-Adams, KJ	1
Adams, JD; Hoffmann, D; LaVoie, EJ; Prokopczyk, G	1
Squier, CA	1
Hecht, SS; Hoffmann, D; Lavoie, EJ	1
Crooks, PA; Olson, JW	1
Andersen, RA; Kemp, TR	1
Barry, BK; Gruetter, CA; Ignarro, LJ; Kadowitz, PJ; McNamara, DB	1
Brittebo, E; Tjälve, H	1
Marlowe, C; Waddell, WJ	1
Brittebo, EB; Löfberg, B; Tjälve, H	1
Hecht, SS; Lin, D; Reiss, B; Williams, GM	1
Castonguay, A; Van Vunakis, H	1
Keeney, AH; Perraut, TC; Waddell, WJ	1
Adams, JD; Hoffmann, D	1
Chen, CB; Hecht, SS; Hoffmann, D; McCoy, GD	1
Chen, CB; Hecht, SS; Hoffmann, D; Lin, D; Young, R	1
Castonguay, A; Hecht, SS; Hoffmann, D; Rivenson, A	1
Hecht, SS; Katayama, S; McCoy, GD; Wynder, EL	1
Brittebo, EB; Tjälve, H	1
Chen, CB; Hecht, SS; Lin, D	1
Chen, CB; Hecht, SS; Hoffmann, D; Ohmori, T	1
Arcos, JC; Argus, MF; Lai, DY	1
Hecht, SS; McCoy, GD; Wynder, EL	1
Chen, CB; Hecht, SS; Hoffmann, D	1
Chen, YP; Johnson, GK; Squier, CA	1
Andersson, G; Björnberg, G; Curvall, M	1
Corvese, D; Weitberg, AB	1
Caldwell, WS; deBethizy, JD; Dobson, GP; Greene, JM	1
Bombick, BR; Doolittle, DJ; Fulp, C; Lee, CK	1
Borukhova, A; Carmella, SG; Desai, D; Hecht, SS	1
Hasséus, B; Hirsch, JM; Jontell, M; Osterdahl, BG; Wallström, M	1
Hecht, SS; Trushin, N	1
Du, X; Kremer, MJ; Squier, CA; Wertz, PW	1
Hee, SS; Yim, SH	1
Minna, JD	1
Barley, RD; Lam, EW; Peters, E; Pollock, S; Shallow, MC	1
Gupta, PC; Hecht, SS; Ramakrishnan, S; Stepanov, I	1
Brown, KM; Murphy, SE; Raulinaitis, V	1
Gonta, M; Hecht, SS; Li, ZZ; Porubin, D; Stepanov, I	1
Hecht, SS; Stepanov, I	1
Carmella, SG; Han, S; Hecht, SS; Lerman, C; Pinto, A; Stepanov, I; Strasser, AA	1
Briggs, A; Carmella, SG; Hatsukami, D; Hecht, SS; Hertsgaard, L; Lindgren, B; Stepanov, I	1
Bowen, SW; Dewey, RE; Keogh, MR; Lewis, RS	1
Hatsukami, DK; Hecht, SS; Knezevich, A; Muzic, J; Stepanov, I	1
Ashley, DL; Ding, YS; Hearn, BA; Polzin, GM; Renner, CC; Stanfill, SB; Vaughan-Watson, C; Watson, CH; Zhang, L	1
Balmes, J; Farraro, KF; Hammond, SK; Jenkins, BM; Perrino, C; Schick, SF; Sleiman, M; Trinh, MP; van de Vossenberg, G	1
Gao, YT; Hecht, SS; Sebero, E; Stepanov, I; Wang, R; Yuan, JM	1
Dhumal, G; Gupta, PC; Hatsukami, D; Parascandola, M; Stepanov, I; Toscano, W; Yershova, K	1
Hecht, SS; Upadhyaya, P	1
Chen, B; Hu, B; Li, XF; Qian, Y; Wu, M; Zhu, L	1
Anderson, A; Broadbent, B; Carmella, S; Hatsukami, DK; Hecht, SS; Jensen, J; Murphy, SE; Severson, H; Vogel, RI	1
Bush, LP; Cai, B; Fannin, FF; Ji, H	1
Cabot, PJ; Moghbel, N; Ryu, B; Steadman, KJ	1
Liu, W; Liu, X; Wang, L; Yang, B; Zhang, C; Zhang, J; Zhou, J	1
Bakaher, N; Bovet, L; Goepfert, S; Lang, G; Laparra, H; Liedschulte, V; Philippon, B; Schwaar, JD; Sierro, N; Vuarnoz, A	1
Lipowicz, PJ; Seeman, JI	1
Adams, A; Danielson, T; Gadani, F; Gunduz, I; Jaccard, G; Kondylis, A; Lion, K; Lusso, M; Morris, W; Ruffieux, L; Strickland, J; Warek, U	1
Daniels, YC; Holman, MR; Johnson, TL; Lane, B; Lang, BE; Lee, GE; Lisko, JG; Phillips, T; Pritchett, JS; Sander, LC; Valentin-Blasini, L; Walters, MJ; Watson, C; Wise, SA; Wood, LJ; Yen, JH	1
da Costa, GG; Loukotková, L; Vanlandingham, M; VonTungeln, LS	1
Chen, H; Hou, H; Hu, Q; Liu, Y; Wang, A; Zhang, S	1
Arnold, LL; Cohen, SM; Kato, H; Naiki, T; Naiki-Ito, A; Pennington, KL; Suzuki, S; Takahashi, S; Yamashita, Y	1
Gao, Y; Li, F; Li, M; Li, W; Liu, C; Song, Z; Sui, X; Wang, B; Yao, X; Zhao, L	1
Chen, G; Lazarus, P; Nasrin, S; Watson, CJW	1
Begou, O; Fatouros, DG; Gika, H; Kontogiannidou, E; Meikopoulos, T; Miller, JH; Panagoulis, T; Theodoridis, G	1
Bitzer, ZT; Mocniak, LE; Prabhu, P; Richie, JP; Trushin, N	1
Battu, JR; Karthik, S; Keerthana, A; Kumar, MPS; Reddy, MSS; Thakur, H; Yashaswini, G	1

Reviews

1 review(s) available for n'-nitrosonornicotine and nicotine

Article	Year
Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer. The Journal of clinical investigation, 2003, Volume: 111, Issue:1 Topics: Animals; Apoptosis; Bronchi; Carcinogens; Enzyme Activation; Epithelial Cells; Humans; Lung Neoplasms; Nicotine; Nitrosamines; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Nicotinic	2003

Article

Year

Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer.

The Journal of clinical investigation, 2003, Volume: 111, Issue:1

Topics: Animals; Apoptosis; Bronchi; Carcinogens; Enzyme Activation; Epithelial Cells; Humans; Lung Neoplasms; Nicotine; Nitrosamines; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Nicotinic

2003

Trials

2 trial(s) available for n'-nitrosonornicotine and nicotine

Article	Year
Evidence for endogenous formation of N'-nitrosonornicotine in some long-term nicotine patch users. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2009, Volume: 11, Issue:1 Topics: Administration, Cutaneous; Adult; Biomarkers; Carcinogens; Female; Humans; Male; Middle Aged; Nicotine; Nitrosamines; Smoking; Smoking Prevention; Time Factors; Tobacco, Smokeless	2009
Randomised clinical trial of snus versus medicinal nicotine among smokers interested in product switching. Tobacco control, 2016, Volume: 25, Issue:3 Topics: Administration, Oral; Adult; Biomarkers; Chewing Gum; Consumer Behavior; Cotinine; Female; Glucuronides; Humans; Male; Middle Aged; Minnesota; Nicotine; Nicotinic Agonists; Nitrosamines; Oregon; Pyridines; Smoking; Smoking Cessation; Smoking Prevention; Time Factors; Tobacco Use Cessation Devices; Tobacco Use Disorder; Tobacco, Smokeless; Treatment Outcome; Urinalysis	2016

Article

Year

Evidence for endogenous formation of N'-nitrosonornicotine in some long-term nicotine patch users.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2009, Volume: 11, Issue:1

Topics: Administration, Cutaneous; Adult; Biomarkers; Carcinogens; Female; Humans; Male; Middle Aged; Nicotine; Nitrosamines; Smoking; Smoking Prevention; Time Factors; Tobacco, Smokeless

2009

Randomised clinical trial of snus versus medicinal nicotine among smokers interested in product switching.

Tobacco control, 2016, Volume: 25, Issue:3

Topics: Administration, Oral; Adult; Biomarkers; Chewing Gum; Consumer Behavior; Cotinine; Female; Glucuronides; Humans; Male; Middle Aged; Minnesota; Nicotine; Nicotinic Agonists; Nitrosamines; Oregon; Pyridines; Smoking; Smoking Cessation; Smoking Prevention; Time Factors; Tobacco Use Cessation Devices; Tobacco Use Disorder; Tobacco, Smokeless; Treatment Outcome; Urinalysis

2016

Other Studies

78 other study(ies) available for n'-nitrosonornicotine and nicotine

Article	Year
Chemical studies on tobacco smoke. XXXIII. N' -nitrosonornicotine in tobacco: analysis of possible contributing factors and biologic implications. Journal of the National Cancer Institute, 1975, Volume: 54, Issue:5 Topics: Alkaloids; Anabasine; Carboxylic Acids; Chromatography, Gas; Hydrogen-Ion Concentration; Mass Spectrometry; Methyl Ethers; Nicotiana; Nicotine; Nitrates; Nitrites; Nitrosamines; Piperidines; Plants, Toxic; Pyridines; Pyrrolidines	1975
Radioimmunoassay of N'-nitrosonornicotine. Analytical biochemistry, 1979, Volume: 95, Issue:2 Topics: Anabasine; Animals; Antibody Specificity; Humans; Nicotine; Nitrosamines; Rabbits; Radioimmunoassay	1979
Assay for microsomal alpha-hydroxylation of N'-nitrosonornicotine and determination of the deuterium isotope effect for alpha-hydroxylation. Cancer research, 1979, Volume: 39, Issue:12 Topics: Animals; Aroclors; Deuterium; Hydroxylation; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Nicotine; Nitrosamines; Rats	1979
Tobacco-specific nitrosamines: formation from nicotine in vitro and during tobacco curing and carcinogenicity in strain A mice. Journal of the National Cancer Institute, 1978, Volume: 60, Issue:4 Topics: Adenoma; Animals; Female; In Vitro Techniques; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasms, Experimental; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Pyridines	1978
A study of tobacco carcinogenesis. XV. Effects of N'-nitrosonornicotine and N'-nitrosoanabasine in Syrian golden hamsters. Cancer letters, 1977, Volume: 2, Issue:3 Topics: Anabasine; Animals; Cricetinae; Female; Male; Mesocricetus; Neoplasms, Experimental; Nicotiana; Nicotine; Nitrosamines; Nose Neoplasms; Piperidines; Plants, Toxic; Smoking; Tracheal Neoplasms	1977
Origin in tobacco smoke of N'-nitrosonornicotine, a tobacco-specific carcinogen. Journal of the National Cancer Institute, 1977, Volume: 58, Issue:6 Topics: Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Smoking	1977
Carcinogenicity of N'-nitrosonornicotine in Sprague-Dawley rats. Journal of the National Cancer Institute, 1976, Volume: 57, Issue:6 Topics: Adenocarcinoma; Animals; Carcinogens; Female; Nasal Cavity; Neoplasms, Experimental; Nicotine; Nitrosamines; Nose Neoplasms; Papilloma; Rats; Smoking; Stomach Neoplasms	1976
Inhibition of herpes simplex virus replication and protein synthesis by non-smoked tobacco, tobacco alkaloids and nitrosamines. Archives of oral biology, 1992, Volume: 37, Issue:11 Topics: Alkaloids; Anabasine; Animals; Carcinogens; Cells, Cultured; Diethylnitrosamine; DNA-Directed DNA Polymerase; Humans; Nicotiana; Nicotine; Nitrosamines; Plant Extracts; Plants, Toxic; Simplexvirus; Thymidine Kinase; Tobacco, Smokeless; Tumor Cells, Cultured; Viral Proteins; Virus Replication	1992
Effect of smokeless tobacco and tobacco-related chemical carcinogens on survival of ultraviolet light-inactivated herpes simplex virus. Oral surgery, oral medicine, and oral pathology, 1991, Volume: 71, Issue:4 Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Line; Chlorocebus aethiops; Kidney; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Simplexvirus; Tobacco, Smokeless; Ultraviolet Rays; Virus Activation	1991
Tobacco-specific nitrosamines in commercial cigarettes: possibilities for reducing exposure. IARC scientific publications, 1991, Issue:105 Topics: Carcinogens; Humans; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Smoke	1991
Effect of nicotine and tobacco-specific nitrosamines on the metabolism of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by rat oral tissue. Carcinogenesis, 1990, Volume: 11, Issue:9 Topics: Animals; Biotransformation; Carcinogens; Cells, Cultured; Chromatography, High Pressure Liquid; Mouth; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Radioisotope Dilution Technique; Rats; Rats, Inbred F344; Tritium	1990
Tobacco-specific nitrosamines in Canadian cigarettes. Journal of cancer research and clinical oncology, 1990, Volume: 116, Issue:6 Topics: Canada; Carcinogens; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic	1990
The migration of tobacco-specific nitrosamines into the saliva of chewers of nicotine-containing chewing gum. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1990, Volume: 28, Issue:9 Topics: Adult; Carcinogens; Chromatography, Gas; Female; Humans; Male; Middle Aged; Nicotine; Nitrosamines; Polymethacrylic Acids; Polyvinyls; Saliva; Tobacco Use Cessation Devices	1990
Investigations on the origin of tobacco-specific nitrosamines in mainstream smoke of cigarettes. Carcinogenesis, 1990, Volume: 11, Issue:5 Topics: Carcinogens; Nicotiana; Nicotine; Nitrates; Nitrosamines; Plants, Toxic; Smoke	1990
Immunoassays for proteins alkylated by nicotine-derived N-nitrosamines. Archives of toxicology, 1990, Volume: 64, Issue:5 Topics: Animals; Carcinogens; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Hydrolysis; Immunoassay; Immunoblotting; Isoelectric Focusing; Killer Cells, Natural; Nicotine; Nitrosamines; Proteins	1990
Toxic and carcinogenic agents in undiluted mainstream smoke and sidestream smoke of different types of cigarettes. Carcinogenesis, 1987, Volume: 8, Issue:5 Topics: Ammonia; Benzo(a)pyrene; Carbon Monoxide; Carcinogens; Hydrogen-Ion Concentration; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Smoke; Tars	1987
Effect of snuff and nicotine on DNA methylation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis, 1987, Volume: 8, Issue:10 Topics: Animals; DNA; Guanine; Liver; Lung; Male; Mathematics; Methylation; Mouth; Nasal Mucosa; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Rats; Rats, Inbred F344; Tobacco, Smokeless	1987
Penetration of nicotine and nitrosonornicotine across porcine oral mucosa. Journal of applied toxicology : JAT, 1986, Volume: 6, Issue:2 Topics: Animals; In Vitro Techniques; Mouth Mucosa; Mouth Neoplasms; Nicotiana; Nicotine; Nitrosamines; Permeability; Plants, Toxic; Swine	1986
Nicotine: a precursor for carcinogens. Cancer letters, 1985, Volume: 26, Issue:1 Topics: Animals; Biotransformation; Carcinogens; Cotinine; Humans; Lung Neoplasms; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Rats; Smoking	1985
Effect of nicotine and N'-nitrosonornicotine on rat lung and trachea ornithine decarboxylase activity. Carcinogenesis, 1985, Volume: 6, Issue:10 Topics: Animals; Dose-Response Relationship, Drug; Enzyme Induction; Lung; Male; Nicotine; Nitrosamines; Ornithine Decarboxylase; Rats; Trachea	1985
Accumulation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone in alkaloid genotypes of burley tobacco during postharvest processing: comparisons with N'-nitrosonornicotine and probable nitrosamine precursors. Cancer research, 1985, Volume: 45, Issue:11 Pt 1 Topics: Alkaloids; Carcinogens; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Time Factors	1985
Coronary arterial relaxation and guanylate cyclase activation by cigarette smoke, N'-nitrosonornicotine and nitric oxide. The Journal of pharmacology and experimental therapeutics, 1980, Volume: 214, Issue:1 Topics: Animals; Arteries; Blood Proteins; Cattle; Coronary Vessels; Dose-Response Relationship, Drug; Enzyme Activation; Ferrocyanides; Guanylate Cyclase; Heme; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nicotine; Nitric Oxide; Nitrosamines; Smoking	1980
Autoradiographic observations on the distribution and metabolism of N'-/14C/nitrosonornicotine in mice. Journal of cancer research and clinical oncology, 1980, Volume: 98, Issue:3 Topics: Animals; Autoradiography; Carbon Radioisotopes; Carcinogens; Ditiocarb; Female; Melanins; Mice; Nialamide; Nicotine; Nitrosamines; Tissue Distribution	1980
Localization of [14C]nitrosonornicotine in tissues of the mouse. Cancer research, 1980, Volume: 40, Issue:10 Topics: Animals; Autoradiography; Carcinogens; Histological Techniques; Injections, Intravenous; Male; Mice; Mice, Inbred C57BL; Nicotine; Nitrosamines; Time Factors; Tissue Distribution	1980
Localization and binding of N'-nitrosonornicotine metabolites in the nasal region and in some other tissues of Sprague-Dawley rats. Cancer research, 1982, Volume: 42, Issue:7 Topics: Animals; Autoradiography; Esophagus; Histocytochemistry; Kidney; Liver; Nasal Mucosa; Nicotine; Nitrosamines; Rats; Rats, Inbred Strains; Respiratory System	1982
Metabolism of N'-nitrosonornicotine by cultured rat esophagus. Carcinogenesis, 1982, Volume: 3, Issue:4 Topics: Animals; Biotransformation; Carcinogens; Esophagus; Liver; Male; Nicotine; Nitrosamines; Organ Culture Techniques; Rats; Rats, Inbred F344	1982
Radioimmunoassays for N'-nitrosonornicotine and N'-acylnornicotine analogs. Methods in enzymology, 1982, Volume: 84 Topics: Animals; Chemical Phenomena; Chemistry; Nicotine; Nitrosamines; Rabbits; Radioimmunoassay	1982
Carcinogenesis and nicotine in malignant melanoma of the choroid. Transactions of the American Ophthalmological Society, 1982, Volume: 80 Topics: Adolescent; Adult; Aged; Autoradiography; Choroid Neoplasms; Female; Humans; Male; Melanoma; Middle Aged; Nicotine; Nitrosamines	1982
Carcinogenic tobacco-specific N-nitrosamines in snuff and in the saliva of snuff dippers. Cancer research, 1981, Volume: 41, Issue:11 Pt 1 Topics: Adult; Alkaloids; Denmark; Germany, West; Humans; Male; Middle Aged; Mouth Neoplasms; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Pyridines; Saliva; Sweden; Tobacco, Smokeless; United States	1981
Assays for metabolic alpha-hydroxylation of N'-nitrosonornicotine and N-nitrosopyrrolidine and the influence of modifying factors. IARC scientific publications, 1980, Issue:31 Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Cricetinae; Ethanol; Hydroxylation; Mesocricetus; Methylcholanthrene; Microsomes, Liver; N-Nitrosopyrrolidine; Nicotine; Nitrosamines; Phenobarbital; Rats	1980
Metabolism of the tobacco specific nitrosamines, N'-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. IARC scientific publications, 1980, Issue:31 Topics: Animals; Biotransformation; Hydroxylation; Liver; Microsomes; Nicotiana; Nicotine; Nitrosamines; Oxidation-Reduction; Plants, Toxic; Pyridines; Rats	1980
Comparative carcinogenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine in Syrian golden hamsters. Cancer research, 1981, Volume: 41, Issue:6 Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cricetinae; Feces; Female; Injections, Subcutaneous; Lung Neoplasms; Male; Mesocricetus; Nasal Cavity; Neoplasms, Experimental; Nicotiana; Nicotine; Nitrosamines; Nose Neoplasms; Plants, Toxic; Pyridines	1981
Differential effect of chronic ethanol consumption on the carcinogenicity of N-nitrosopyrrolidine and N'-nitrosonornicotine in male Syrian golden hamsters. Cancer research, 1981, Volume: 41, Issue:7 Topics: Alcohol Drinking; Animals; Biotransformation; Carcinogens; Cricetinae; Injections, Intraperitoneal; Male; Mesocricetus; N-Nitrosopyrrolidine; Nasal Cavity; Nicotine; Nitrosamines; Nose Neoplasms; Tracheal Neoplasms	1981
Formation of tissue-bound N'-nitrosonornicotine metabolites by the target tissues of Sprague-Dawley and Fisher rats. Carcinogenesis, 1981, Volume: 2, Issue:10 Topics: Animals; Autoradiography; Biotransformation; Carcinogens; Nicotine; Nitrosamines; Rats; Rats, Inbred F344; Rats, Inbred Strains; Species Specificity	1981
Comprehensive analysis of urinary metabolites of N'-nitrosonornicotine. Carcinogenesis, 1981, Volume: 2, Issue:9 Topics: Animals; Biotransformation; Carcinogens; Chromatography, High Pressure Liquid; Cricetinae; Male; Mesocricetus; Mice; Mice, Inbred A; Nicotine; Nitrosamines; Rats; Rats, Inbred F344; Species Specificity	1981
Comparative carcinogenicity in F344 rats of the tobacco-specific nitrosamines, N'-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. Cancer research, 1980, Volume: 40, Issue:2 Topics: Animals; Carcinogens; Female; Liver Neoplasms; Lung Neoplasms; Male; Nasal Cavity; Neoplasms, Experimental; Nicotiana; Nicotine; Nitrosamines; Nose Neoplasms; Plants, Toxic; Pyridines; Rats; Rats, Inbred F344	1980
Interaction of the tobacco-specific nitrosamines, methylethylnitrosamine and N-nitrosonornicotine, with DNA and guanosine. Research communications in chemical pathology and pharmacology, 1980, Volume: 28, Issue:1 Topics: Animals; Benzylamines; Dimethylnitrosamine; DNA; Guanosine; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; Nicotiana; Nicotine; Nitrosamines; Phenobarbital; Plants, Toxic; Rats	1980
The roles of tobacco, alcohol, and diet in the etiology of upper alimentary and respiratory tract cancers. Preventive medicine, 1980, Volume: 9, Issue:5 Topics: Alcohol Drinking; Animals; Cricetinae; Diet; Esophageal Neoplasms; Humans; Laryngeal Neoplasms; Liver; Mouth Neoplasms; N-Nitrosopyrrolidine; Nicotine; Nitrosamines; Risk; Smoking	1980
Metabolic beta-hydroxylation and N-oxidation of N'-nitrosonornicotine. Journal of medicinal chemistry, 1980, Volume: 23, Issue:11 Topics: Animals; Carcinogens; Hydroxylation; In Vitro Techniques; Microsomes, Liver; Nicotine; Nitrosamines; Oxidation-Reduction; Rats	1980
Effects of nicotine and tobacco-specific nitrosamines on hamster cheek pouch and gastric mucosa. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1994, Volume: 23, Issue:6 Topics: Animals; Carcinogens; Cheek; Cricetinae; Drug Synergism; Epithelium; Gastric Mucosa; Hyperplasia; Keratosis; Leukoplakia, Oral; Male; Mesocricetus; Mouth Mucosa; Nicotine; Nitrosamines; Papilloma; Plants, Toxic; Tobacco, Smokeless	1994
Oral mucosal changes and nicotine disposition in users of Swedish smokeless tobacco products: a comparative study. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1994, Volume: 23, Issue:4 Topics: Adult; Cotinine; Glucuronates; Glucuronic Acid; Humans; Leukoedema, Oral; Male; Middle Aged; Mouth Diseases; Mouth Mucosa; Nicotine; Nitrosamines; Plants, Toxic; Saliva; Sweden; Tobacco, Smokeless	1994
Oxygen radicals potentiate the genetic toxicity of tobacco-specific nitrosamines. Clinical genetics, 1993, Volume: 43, Issue:2 Topics: Carcinogens; Cells, Cultured; DNA Damage; DNA, Single-Stranded; Drug Synergism; Fetus; Fibroblasts; Free Radical Scavengers; Free Radicals; Humans; Lung; Mutagens; Nicotiana; Nicotine; Nitrosamines; Nucleic Acid Denaturation; Plants, Toxic; Reactive Oxygen Species	1993
Intragastric nitrosation of nicotine is not a significant contributor to nitrosamine exposure. Annals of the New York Academy of Sciences, 1993, May-28, Volume: 686 Topics: Butanones; Carcinogens; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Models, Biological; Nicotine; Nitrosamines; Nitrosation; Sodium Nitrite; Stomach	1993
Inhibition of mutagenicity of N-nitrosamines by tobacco smoke and its constituents. Mutation research, 1996, Volume: 367, Issue:2 Topics: Animals; Antimutagenic Agents; CHO Cells; Cotinine; Cricetinae; Dimethylnitrosamine; Dose-Response Relationship, Drug; Nicotine; Nitrosamines	1996
Evidence for endogenous formation of tobacco-specific nitrosamines in rats treated with tobacco alkaloids and sodium nitrite. Carcinogenesis, 1997, Volume: 18, Issue:3 Topics: Alkaloids; Animals; Biotransformation; Drug Synergism; Glucuronates; Male; Nicotiana; Nicotine; Nitrosamines; Plant Extracts; Plants, Toxic; Rats; Rats, Inbred F344; Sodium Nitrite	1997
Immunotoxic effects of smokeless tobacco on the accessory cell function of rat oral epithelium. European journal of oral sciences, 1997, Volume: 105, Issue:1 Topics: Alkaloids; Anabasine; Animals; Antigen-Presenting Cells; Carcinogens; Cell Division; Concanavalin A; Epithelial Cells; Epithelium; Immunosuppressive Agents; Langerhans Cells; Lymphocyte Activation; Mitogens; Mouth Mucosa; Nicotine; Nitrosamines; Nitroso Compounds; Plant Extracts; Plant Lectins; Plants, Toxic; Rats; Rats, Inbred Lew; Spleen; T-Lymphocytes; Tobacco, Smokeless	1997
Stereoselective metabolism of nicotine and tobacco-specific N-nitrosamines to 4-hydroxy-4-(3-pyridyl)butanoic acid in rats. Chemical research in toxicology, 1999, Volume: 12, Issue:2 Topics: Animals; Biotransformation; Carcinogens; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Humans; Hydroxybutyrates; Hydroxylation; Male; Microsomes, Liver; Nicotine; Nitrosamines; Pyridines; Rats; Rats, Inbred F344; Stereoisomerism	1999
Penetration of N-nitrosonornicotine (NNN) across oral mucosa in the presence of ethanol and nicotine. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2000, Volume: 29, Issue:2 Topics: Analysis of Variance; Animals; Carcinogens; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Mouth Mucosa; Mouth Neoplasms; Nicotine; Nicotinic Agonists; Nitrosamines; Permeability; Plants, Toxic; Smoking; Swine; Tobacco, Smokeless	2000
Bacterial mutagenicity of some tobacco aromatic nitrogen bases and their mixtures. Mutation research, 2001, May-31, Volume: 492, Issue:1-2 Topics: Animals; Carcinogens; Cotinine; Cricetinae; Dose-Response Relationship, Drug; Drug Interactions; Microsomes, Liver; Mutagenicity Tests; Mutagens; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Vibrio	2001
Tobacco-related-compound-induced nitrosative stress injury in the hamster cheek pouch. Journal of dental research, 2004, Volume: 83, Issue:12 Topics: Animals; Carcinogens; Cell Survival; Cells, Cultured; Chromatin; Cricetinae; DNA Damage; DNA, Single-Stranded; Dose-Response Relationship, Drug; Mesocricetus; Mouth Mucosa; Nicotine; Nitrosamines; Oxidative Stress; Peroxynitrous Acid; Tobacco, Smokeless; Tyrosine	2004
Tobacco-specific nitrosamines in smokeless tobacco products marketed in India. International journal of cancer, 2005, Aug-10, Volume: 116, Issue:1 Topics: Carcinogens; Humans; India; Nicotine; Nitrates; Nitrites; Nitrosamines; Tobacco, Smokeless	2005
Nicotine 5'-oxidation and methyl oxidation by P450 2A enzymes. Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:8 Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cotinine; Cytochrome P-450 CYP2A6; Humans; In Vitro Techniques; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Nicotine; Nitrosamines; Smoking; Steroid Hydroxylases; Tritium	2005
Endogenous formation of N'-nitrosonornicotine in F344 rats in the presence of some antioxidants and grape seed extract. Journal of agricultural and food chemistry, 2007, Aug-22, Volume: 55, Issue:17 Topics: Animals; Antioxidants; Carcinogens; Male; Nicotine; Nitrosamines; Plant Extracts; Rats; Rats, Inbred F344; Seeds; Sodium Nitrite; Vitis	2007
Detection and quantitation of N'-nitrosonornicotine in human toenails by liquid chromatography-electrospray ionization-tandem mass spectrometry. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008, Volume: 17, Issue:4 Topics: Biomarkers; Carcinogens; Chromatography, Liquid; Humans; Nails; Nicotine; Nitrosamines; Pyridines; Tandem Mass Spectrometry	2008
Presence of the carcinogen N'-nitrosonornicotine in the urine of some users of oral nicotine replacement therapy products. Cancer research, 2009, Nov-01, Volume: 69, Issue:21 Topics: Biomarkers; Carcinogens; Humans; Nicotine; Nitrosamines; Smoking; Smoking Cessation; Smoking Prevention; Tobacco, Smokeless	2009
Three nicotine demethylase genes mediate nornicotine biosynthesis in Nicotiana tabacum L.: functional characterization of the CYP82E10 gene. Phytochemistry, 2010, Volume: 71, Issue:17-18 Topics: Carcinogens; Cytochrome P-450 Enzyme System; Molecular Structure; Nicotiana; Nicotine; Nitrosamines; Plant Leaves; Plant Proteins	2010
Nornicotine nitrosation in saliva and its relation to endogenous synthesis of N'-nitrosonornicotine in humans. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2013, Volume: 15, Issue:2 Topics: Humans; Nicotine; Nitrosamines; Nitrosation; Saliva; Smoking; Smoking Cessation	2013
Chemical analysis of Alaskan Iq'mik smokeless tobacco. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2013, Volume: 15, Issue:7 Topics: Alaska; Benzo(a)pyrene; Humans; Hydrogen-Ion Concentration; Inuit; Nicotine; Nitrosamines; Polycyclic Aromatic Hydrocarbons; Tobacco, Smokeless	2013
Thirdhand cigarette smoke in an experimental chamber: evidence of surface deposition of nicotine, nitrosamines and polycyclic aromatic hydrocarbons and de novo formation of NNK. Tobacco control, 2014, Volume: 23, Issue:2 Topics: Administration, Inhalation; Carcinogens; Cotinine; Dust; Environmental Exposure; Humans; Nicotiana; Nicotine; Nitrosamines; Polycyclic Aromatic Hydrocarbons; Skin Absorption; Smoking; Tobacco Smoke Pollution	2014
Tobacco-specific N-nitrosamine exposures and cancer risk in the Shanghai Cohort Study: remarkable coherence with rat tumor sites. International journal of cancer, 2014, May-15, Volume: 134, Issue:10 Topics: Animals; Asian People; Case-Control Studies; China; Cohort Studies; Humans; Logistic Models; Lung Neoplasms; Male; Middle Aged; Molecular Structure; Multivariate Analysis; Nicotiana; Nicotine; Nitrosamines; Phenanthrenes; Rats; Risk Factors; Smoking	2014
High levels of tobacco-specific N-nitrosamines and nicotine in Chaini Khaini, a product marketed as snus. Tobacco control, 2015, Volume: 24, Issue:e4 Topics: Carcinogens; Humans; India; Inhalation Exposure; Nicotine; Nitrates; Nitrites; Nitrosamines; Tobacco, Smokeless	2015
Quantitative analysis of 3'-hydroxynorcotinine in human urine. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2015, Volume: 17, Issue:5 Topics: Adult; Biomarkers; Carcinogens; Chromatography, Liquid; Female; Humans; Male; Middle Aged; Nicotine; Nitrosamines; Reproducibility of Results; Smoking; Smoking Cessation; Spectrometry, Mass, Electrospray Ionization	2015
Identification of precursors and mechanisms of tobacco-specific nitrosamine formation in water during chloramination. Environmental science & technology, 2015, Jan-06, Volume: 49, Issue:1 Topics: Alkaloids; Chloramines; Chromatography, Liquid; Drinking Water; Halogenation; Mass Spectrometry; Nicotiana; Nicotine; Nitrosamines; Pyridines; Solid Phase Extraction; Tandem Mass Spectrometry; Water Pollutants, Chemical	2015
Contribution of Nicotine and Nornicotine toward the Production of N'-Nitrosonornicotine in Air-Cured Tobacco (Nicotiana tabacum). Journal of natural products, 2016, Apr-22, Volume: 79, Issue:4 Topics: Alkaloids; Carcinogens; Molecular Structure; Nicotiana; Nicotine; Nitrosamines; North Carolina; Plant Leaves; Stereoisomerism	2016
In vitro cytotoxicity of Nicotiana gossei leaves, used in the Australian Aboriginal smokeless tobacco known as pituri or mingkulpa. Toxicology letters, 2016, 07-08, Volume: 254 Topics: Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Lung; Nicotiana; Nicotine; Nitrosamines; Plant Extracts; Plant Leaves; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry; Tobacco, Smokeless	2016
In vitro metabolism of N'-Nitrosonornicotine catalyzed by cytochrome P450 2A13 and its inhibition by nicotine, N'-Nitrosoanatabine and N'-Nitrosoanabasine. Chemico-biological interactions, 2016, Dec-25, Volume: 260 Topics: Aryl Hydrocarbon Hydroxylases; Biocatalysis; Butanones; Humans; Kinetics; Metabolic Networks and Pathways; Metabolome; Nicotine; Nitrosamines; Pyridines	2016
Identification of CYP82E21 as a functional nicotine N-demethylase in tobacco flowers. Phytochemistry, 2016, Volume: 131 Topics: Cytochrome P-450 Enzyme System; Flowers; Nicotiana; Nicotine; Nitrosamines; Oxidoreductases, N-Demethylating; Plant Leaves; Plant Proteins; RNA Interference	2016
A Model To Estimate the Sources of Tobacco-Specific Nitrosamines in Cigarette Smoke. Chemical research in toxicology, 2017, 08-21, Volume: 30, Issue:8 Topics: Carcinogenesis; Gases; Humans; Models, Chemical; Nicotiana; Nicotine; Nitrosamines; Smoking; Temperature	2017
Novel approach for selective reduction of NNN in cigarette tobacco filler and mainstream smoke. Regulatory toxicology and pharmacology : RTP, 2017, Volume: 89 Topics: Alleles; Cytochrome P-450 Enzyme System; Nicotiana; Nicotine; Nitrosamines; Seeds; Smoke; Tobacco Products	2017
Development of a Cigarette Tobacco Filler Standard Reference Material. Analytical chemistry, 2017, 10-03, Volume: 89, Issue:19 Topics: Chromatography, High Pressure Liquid; Freezing; Gas Chromatography-Mass Spectrometry; Nicotine; Nitrosamines; Phase Transition; Reference Standards; Tandem Mass Spectrometry; Tobacco Products; Volatile Organic Compounds	2017
A simple and highly sensitive UPLC-ESI-MS/MS method for the simultaneous quantification of nicotine, cotinine, and the tobacco-specific carcinogens N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in serum samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018, Jan-01, Volume: 1072 Topics: Carcinogens; Chromatography, High Pressure Liquid; Cotinine; Drug Stability; Humans; Limit of Detection; Linear Models; Nicotine; Nitrosamines; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2018
Genotoxicity analysis of five particle matter toxicants from cigarette smoke based on γH2AX assay combined with Hill/Two-component model. Environmental toxicology and pharmacology, 2018, Volume: 58 Topics: A549 Cells; Benzo(a)pyrene; Biological Assay; Cell Survival; Histones; Humans; Models, Biological; Nicotine; Nitrosamines; Smoke; Tobacco Products	2018
Cotinine, a major nicotine metabolite, induces cell proliferation on urothelium in vitro and in vivo. Toxicology, 2020, 01-15, Volume: 429 Topics: Animals; Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cotinine; Humans; Male; Nicotine; Nitrosamines; Rats; Rats, Inbred F344; Urinary Bladder; Urinary Bladder Neoplasms; Urothelium	2020
Development of a nornicotine-reduced flue-cured tobacco line via EMS mutagenesis of nicotine N-demethylase genes. Plant signaling & behavior, 2020, Volume: 15, Issue:2 Topics: Cytochrome P-450 Enzyme System; Ethyl Methanesulfonate; Nicotiana; Nicotine; Nitrosamines; Plant Leaves; Plant Proteins; RNA Interference	2020
Comparison of tobacco-specific nitrosamine levels in smokeless tobacco products: High levels in products from Bangladesh. PloS one, 2020, Volume: 15, Issue:5 Topics: Bangladesh; Chromatography, Liquid; Nicotiana; Nicotine; Nitrosamines; Tandem Mass Spectrometry; Tobacco Products; Tobacco, Smokeless	2020
UHPLC-MS/MS method for the simultaneous determination of nicotine and tobacco-specific nitrosamines NNN and NNK for use in preclinical studies. Analytical and bioanalytical chemistry, 2022, Volume: 414, Issue:27 Topics: Carcinogens; Chromatography, High Pressure Liquid; Nicotiana; Nicotine; Nitrosamines; Phosphates; Plant Extracts; Tandem Mass Spectrometry	2022
Tobacco Nitrate and Free Radical Levels in the Mainstream Smoke of US Cigarette Brands. Chemical research in toxicology, 2023, 04-17, Volume: 36, Issue:4 Topics: Carcinogens; Free Radicals; Nicotiana; Nicotine; Nitrates; Nitrosamines; Smoke; Tobacco Products	2023
LC-MS/MS analysis of carcinogenic tobacco-specific nitrosamines in Spodoptera litura using the QuEChERS method. Scientific reports, 2023, 07-27, Volume: 13, Issue:1 Topics: Alkaloids; Animals; Biomarkers; Carcinogenesis; Carcinogens; Chromatography, Liquid; Humans; Nicotiana; Nicotine; Nitrosamines; Rats; Spodoptera; Tandem Mass Spectrometry	2023