n-(phenylsulfonyl)benzamide and ajoene

n-(phenylsulfonyl)benzamide has been researched along with ajoene* in 1 studies

*ajoene: major antiplatelet compound in methanol extract of garlic; also inhibits trypanothione reductase. [MeSH]

Other Studies

1 other study(ies) available for n-(phenylsulfonyl)benzamide and ajoene

Article	Year
Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa. Journal of medicinal chemistry, 2017, 01-12, Volume: 60, Issue:1 Since its discovery 22 years ago, the bacterial cell-to-cell communication system, termed quorum sensing (QS), has shown potential as antipathogenic target. Previous studies reported that ajoene from garlic inhibits QS in opportunistic human pathogen Pseudomonas aeruginosa. In this study, screening of an in-house compound library revealed two sulfur-containing compounds which possess structural resemblance with ajoene and inhibit QS in bioreporter assay. Following a quantitative structure-activity relationship (SAR) study, 25 disulfide bond-containing analogues were synthesized and tested for QS inhibition activities. SAR study indicated that the allyl group could be replaced with other substituents, with the most active being benzothiazole derivative (IC Topics: Animals; Anti-Bacterial Agents; Cell Line; Disulfides; Female; Mice; Mice, Inbred BALB C; Pseudomonas aeruginosa; Quorum Sensing; Structure-Activity Relationship; Sulfoxides; Virulence	2017

Article

Year

Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa.

Journal of medicinal chemistry, 2017, 01-12, Volume: 60, Issue:1

Since its discovery 22 years ago, the bacterial cell-to-cell communication system, termed quorum sensing (QS), has shown potential as antipathogenic target. Previous studies reported that ajoene from garlic inhibits QS in opportunistic human pathogen Pseudomonas aeruginosa. In this study, screening of an in-house compound library revealed two sulfur-containing compounds which possess structural resemblance with ajoene and inhibit QS in bioreporter assay. Following a quantitative structure-activity relationship (SAR) study, 25 disulfide bond-containing analogues were synthesized and tested for QS inhibition activities. SAR study indicated that the allyl group could be replaced with other substituents, with the most active being benzothiazole derivative (IC

Topics: Animals; Anti-Bacterial Agents; Cell Line; Disulfides; Female; Mice; Mice, Inbred BALB C; Pseudomonas aeruginosa; Quorum Sensing; Structure-Activity Relationship; Sulfoxides; Virulence

2017