Page last updated: 2024-09-03

n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine and ponatinib

n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine has been researched along with ponatinib in 3 studies

Compound Research Comparison

Studies
(n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine)
Trials
(n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine)
Recent Studies (post-2010)
(n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine)
Studies
(ponatinib)
Trials
(ponatinib)
Recent Studies (post-2010) (ponatinib)
7911653834519

Protein Interaction Comparison

ProteinTaxonomyn-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine (IC50)ponatinib (IC50)
Receptor-interacting serine/threonine-protein kinase 2Homo sapiens (human)0.0038
Tyrosine-protein kinase JAK2Homo sapiens (human)0.169
Tyrosine-protein kinase ABL1Homo sapiens (human)0.0037
Proto-oncogene tyrosine-protein kinase SrcGallus gallus (chicken)0.0009
High affinity nerve growth factor receptorHomo sapiens (human)0.0114
Tyrosine-protein kinase LckHomo sapiens (human)0.0003
Tyrosine-protein kinase FynHomo sapiens (human)0.0004
Macrophage colony-stimulating factor 1 receptorHomo sapiens (human)0.0086
Tyrosine-protein kinase YesHomo sapiens (human)0.0009
Tyrosine-protein kinase LynHomo sapiens (human)0.0008
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)0.0357
Hepatocyte growth factor receptorHomo sapiens (human)0.0017
Tyrosine-protein kinase HCKHomo sapiens (human)0.0001
Platelet-derived growth factor receptor betaHomo sapiens (human)0.0012
Mast/stem cell growth factor receptor KitHomo sapiens (human)0.0271
Breakpoint cluster region proteinHomo sapiens (human)0.0008
Fibroblast growth factor receptor 1Homo sapiens (human)0.0016
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)0.0053
Platelet-derived growth factor receptor alphaHomo sapiens (human)0.0016
cAMP-dependent protein kinase catalytic subunit alphaHomo sapiens (human)0.613
Vascular endothelial growth factor receptor 1 Homo sapiens (human)0.0123
Ephrin type-A receptor 1Homo sapiens (human)0.143
Fibroblast growth factor receptor 2Homo sapiens (human)0.0018
Fibroblast growth factor receptor 4Homo sapiens (human)0.0058
Fibroblast growth factor receptor 3Homo sapiens (human)0.0099
Tyrosine-protein kinase JAK1Homo sapiens (human)0.0322
Ephrin type-A receptor 2Homo sapiens (human)0.0013
Vascular endothelial growth factor receptor 2Homo sapiens (human)0.0053
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)0.0086
Tyrosine-protein kinase CSKHomo sapiens (human)0.0127
Tyrosine-protein kinase FRKHomo sapiens (human)0.0013
Glycogen synthase kinase-3 betaHomo sapiens (human)2.8
Epithelial discoidin domain-containing receptor 1Homo sapiens (human)0.0094
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)4.385
Receptor-interacting serine/threonine-protein kinase 1Homo sapiens (human)0.012
Coiled-coil domain-containing protein 6Homo sapiens (human)0.1804
Mitogen-activated protein kinase 14Homo sapiens (human)0.01
Leucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)0.48
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)0.04
Receptor-interacting serine/threonine-protein kinase 3Homo sapiens (human)0.0016

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Jadhav, A; Kerns, E; Nguyen, K; Shah, P; Sun, H; Xu, X; Yan, Z; Yu, KR1
Kabir, M; Kerns, E; Nguyen, K; Shah, P; Sun, H; Wang, Y; Xu, X; Yu, KR1
Kabir, M; Kerns, E; Neyra, J; Nguyen, K; Nguyễn, ÐT; Shah, P; Siramshetty, VB; Southall, N; Williams, J; Xu, X; Yu, KR1

Other Studies

3 other study(ies) available for n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine and ponatinib

ArticleYear
Highly predictive and interpretable models for PAMPA permeability.
    Bioorganic & medicinal chemistry, 2017, 02-01, Volume: 25, Issue:3

    Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Humans; Models, Biological; Organic Chemicals; Regression Analysis; Support Vector Machine

2017
Predictive models of aqueous solubility of organic compounds built on A large dataset of high integrity.
    Bioorganic & medicinal chemistry, 2019, 07-15, Volume: 27, Issue:14

    Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility

2019
Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models.
    Scientific reports, 2020, 11-26, Volume: 10, Issue:1

    Topics: Animals; Computer Simulation; Databases, Factual; Drug Discovery; High-Throughput Screening Assays; Liver; Machine Learning; Male; Microsomes, Liver; National Center for Advancing Translational Sciences (U.S.); Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Retrospective Studies; United States

2020