n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine has been researched along with leucine in 56 studies
| Studies (n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine) | Trials (n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine) | Recent Studies (post-2010) (n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine) | Studies (leucine) | Trials (leucine) | Recent Studies (post-2010) (leucine) |
|---|---|---|---|---|---|
| 79 | 1 | 16 | 28,515 | 744 | 4,178 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (33.93) | 18.7374 |
| 1990's | 18 (32.14) | 18.2507 |
| 2000's | 14 (25.00) | 29.6817 |
| 2010's | 4 (7.14) | 24.3611 |
| 2020's | 1 (1.79) | 2.80 |
| Authors | Studies |
|---|---|
| Ivy, GO | 1 |
| Katunuma, N; Nikawa, T; Ohshita, T; Towatari, T | 1 |
| Fagan, JM; Waxman, L | 1 |
| Detwiler, TC; Huang, Z; McGowan, EB | 1 |
| Inuzuka, T; Kirino, T; Miyatake, T; Sato, S; Tamura, A; Toyoshima, I | 1 |
| Barrett, AJ; Buttle, DJ; Saklatvala, J; Tamai, M | 1 |
| Inoue, M; Ishida, T; Yamamoto, D | 1 |
| Ivy, GO; Kanai, S; Kitani, K; Nokubo, M; Ohta, M; Otsubo, K; Sato, Y | 1 |
| Blest, AD; Farber, DB; Moldrawski, MR; Shuster, TA; Williams, DS | 1 |
| Kakkar, VV; Krishnamurthi, S; Patel, Y; Sadowska, K; Wheeler-Jones, CP | 1 |
| Fujihara, M; Hoshino, N; Kimura, I; Kimura, M; Kobayashi, S | 1 |
| Mazda, T; Ogasawara, K | 1 |
| Inoue, M; Ishida, T; Kitamura, K; Matsumoto, K; Mizuno, H; Ohishi, H; Sadatome, T; Tomoo, K; Yamamoto, D | 1 |
| Kosaki, G; Suzuki, K; Tanoue, K; Yamamoto, K; Yamazaki, H | 1 |
| Kadkhodayan, S; McDonald, JK | 1 |
| Kelly, RA; May, RC; Mitch, WE | 1 |
| Kurita, Y; Nakao, H; Ogawa, H; Takamori, K; Tsuboi, R | 1 |
| Bando, Y; Katunuma, N; Kominami, E; Tsukahara, T | 1 |
| Ishiura, S; Kamakura, K; Sano, M; Sugita, H | 1 |
| Hanada, K; Ishiura, S; Kashiwagi, K; Sugita, H; Tamai, M | 1 |
| Aoyagi, T; Kojima, F; Nagai, M; Umezawa, H; Umezawa, K; Wada, T | 1 |
| Goldberg, AL; Gronostajski, RM; Pardee, AB | 1 |
| Ishiura, S; Nakase, H; Nonaka, I; Sugita, H; Tada, A | 1 |
| Ishiura, S; Nonaka, I; Sugita, H | 1 |
| Heffner, RR; Hudecki, MS; Pollina, CM | 1 |
| Isogai, K; Katunuma, N; Noda, T; Ohzeki, M; Tarumoto, Y | 1 |
| Nakagawa, Y; Niibayashi, H; Shimizu, K; Yamamoto, S; Yamamuro, T; Yasuda, T | 1 |
| Kakiuchi, T; Kasai, M; Kominami, E; Mizuochi, T; Muno, D; Yee, ST | 1 |
| Anandaraj, MP; Devi, CV | 1 |
| Akedo, H; Mukai, M; Shinkai, K; Yoshioka, K | 1 |
| Kai, M; Nohta, H; Ohkura, Y; Takano, C | 1 |
| Barrett, AJ; Buttle, DJ; Saklatvala, J | 1 |
| Arthur, GD; Belcastro, AN | 1 |
| Belcastro, AN; Booker, TS; Raj, DA | 1 |
| Beertsen, W; Buttle, DJ; Creemers, LB; Everts, V; Hoeben, KA; Jansen, DC | 1 |
| Kohda, Y; Kominami, E; Tsuchiya, K; Ueno, T; Yamashima, T; Yamashita, J; Yoshida, M; Yoshioka, T; Zhao, L | 1 |
| Brush, M; Moretti-Rojas, I; Rojas, FJ | 1 |
| Hara, T; In, Y; Ishida, T; Kitamura, K; Matsugi, K; Murata, M; Tomoo, K; Yamamoto, A | 1 |
| Kohda, Y; Kominami, E; Matsuda, M; Tonchev, AB; Tsuchiya, K; Yamashima, T; Yoshida, M; Zhao, L | 1 |
| Pollack, JR; Sugimoto, JT; Witt, RC | 1 |
| Hook, VY; Reisine, TD | 1 |
| Campbell, RL; Cuerrier, D; Davies, PL; Moldoveanu, T | 1 |
| Hayashi, M; Inomata, M; Ishibashi, H; Kawashima, S; Koshihara, Y; Saido, TC; Tsubuki, S; Yamamoto, S | 1 |
| Kaledin, VI; Khoshchenko, OM; Korolenko, TA; Nikolin, VP; Spiridonov, VK; Zhanaeva, SY | 1 |
| Häggström, L; Lindskog, E; Svensson, I | 1 |
| Bräuer, R; Christiansen, C; Danielsen, I; Henriksen, K; Karsdal, MA; Oestergaard, S; Qvist, P; Schurigt, U; Sondergaard, BC; Wulf, H | 1 |
| Hiroi, Y; Ohshita, T | 1 |
| Aganna, E; Burrin, JM; Hitman, GA; Turner, MD | 1 |
| Alberti-Navarro, A; Alcala-Canto, Y; Gracia-Mora, J; Ibarra-Velarde, F; Sumano-Lopez, H | 1 |
| Moreira, R; Santos, MM | 1 |
| Arnone, M; Engels, B; Fink, RF; Mladenovic, M | 1 |
| Higuchi, T; Hillmer, S; Inoue, Y; Moriyasu, Y; Robinson, DG; Takatsuka, C | 1 |
| Grundhuber, M; Klimpel, D; Radzey, H; Rethmeier, M; Schaschke, N; Sommerhoff, CP | 1 |
| Inoue, Y; Moriyasu, Y; Mukae, K; Niwa, Y; Yanagisawa, T; Yano, K | 1 |
| Inoue-Aono, Y; Moriyasu, Y; Takatsuka, C | 1 |
| Rethmeier, M; Schaschke, N; Sommerhoff, CP; Tromsdorf, N; Ullrich, FTH | 1 |
1 review(s) available for n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine and leucine
| Article | Year |
|---|---|
Michael acceptors as cysteine protease inhibitors.
Topics: Animals; Cysteine Proteinase Inhibitors; Drug Design; Humans; Isoxazoles; Leucine; Molecular Structure; Oxazoles; Peptides; Phenylalanine; Pyrrolidines; Pyrrolidinones; Structure-Activity Relationship; Sulfones; Valine | 2007 |
1 trial(s) available for n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine and leucine
| Article | Year |
|---|---|
Effect of a cysteine protease inhibitor on Fasciola hepatica (liver fluke) fecundity, egg viability, parasite burden, and size in experimentally infected sheep.
Topics: Animals; Cysteine Proteinase Inhibitors; Fasciola hepatica; Fascioliasis; Fertility; Leucine; Ovum; Sheep; Sheep Diseases | 2007 |
54 other study(ies) available for n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine and leucine
| Article | Year |
|---|---|
Protease inhibition causes some manifestations of aging and Alzheimer's disease in rodent and primate brain.
Topics: Aging; Alzheimer Disease; Animals; Brain; Dolichols; Endopeptidases; Humans; Immunologic Techniques; Intermediate Filaments; Leucine; Leupeptins; Lipofuscin; Macaca fascicularis; Male; Protease Inhibitors; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Ubiquitins | 1992 |
Effects of selective inhibition of cathepsin B and general inhibition of cysteine proteinases on lysosomal proteolysis in rat liver in vivo and in vitro.
Topics: alpha-Fetoproteins; Animals; Asialoglycoproteins; Cathepsin B; Chromatography, Gel; Cysteine Proteinase Inhibitors; Dipeptides; Fetuins; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Leucine; Liver; Lysosomes; Male; Rats; Rats, Wistar | 1992 |
The ATP-independent pathway in red blood cells that degrades oxidant-damaged hemoglobin.
Topics: Adenosine Triphosphate; Animals; Azides; Calcimycin; Cations, Divalent; Cysteine Proteinase Inhibitors; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Hemoglobins; Hydrogen Peroxide; Ionomycin; Kinetics; Leucine; Male; Oxidants; Phenylhydrazines; Pyrimidinones; Rabbits; Rats | 1992 |
Ester and amide derivatives of E64c as inhibitors of platelet calpains.
Topics: Adult; Blood Platelets; Calcimycin; Calcium; Calpain; Cysteine Proteinase Inhibitors; Esters; Humans; Leucine; Serotonin; Structure-Activity Relationship | 1992 |
Suppressive effect of E-64c on ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats.
Topics: Animals; Calpain; Cerebral Arteries; Immunoblotting; Ischemic Attack, Transient; Leucine; Male; Microtubule-Associated Proteins; Myelin Proteins; Myelin-Associated Glycoprotein; Rats; Rats, Inbred Strains | 1990 |
Inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by a lipophilic inactivator of cysteine endopeptidases.
Topics: Animals; Cartilage; Cattle; Cysteine Proteinase Inhibitors; Interleukin-1; Iodoacetates; Iodoacetic Acid; Leucine; Proteoglycans; Recombinant Proteins | 1992 |
A comparison between the binding modes of a substrate and inhibitor to papain as observed in complex crystal structures.
Topics: Amino Acid Chloromethyl Ketones; Binding Sites; Crystallization; Cysteine Proteinase Inhibitors; Leucine; Models, Molecular; Papain; Protein Binding; Protein Conformation; X-Ray Diffraction | 1990 |
Morphological, physiological and biochemical alterations in livers of rodents induced by protease inhibitors: a comparison with old livers.
Topics: Aging; Animals; Biological Transport; Dolichols; Leucine; Leupeptins; Liver; Male; Mice; Mice, Inbred C57BL; Ouabain; Protease Inhibitors; Rats; Rats, Inbred F344; Rats, Inbred Strains; Sulfobromophthalein | 1989 |
Isolation of rod outer segments on Percoll gradients: effect of specific protease inhibition.
Topics: Animals; Centrifugation, Density Gradient; Leucine; Photoreceptor Cells; Povidone; Protease Inhibitors; Rats; Rod Cell Outer Segment; Silicon Dioxide | 1989 |
Effects of the calpain inhibitor E64-d on platelet activation responses.
Topics: Calpain; Cysteine Proteinase Inhibitors; Humans; In Vitro Techniques; Leucine; Platelet Activation | 1989 |
Diabetic state-induced activation of calcium-activated neutral proteinase in mouse skeletal muscle.
Topics: Actinin; Animals; Calcium; Calpain; Cell Membrane; Creatine Kinase; Cysteine Proteinase Inhibitors; Diabetes Mellitus, Experimental; Edetic Acid; Egtazic Acid; Electrophoresis; Enzyme Activation; Leucine; Male; Mice; Muscles | 1989 |
Differences in substrate specificities for cysteine proteinases used in blood group serology, and the use of bromelain in a two-phase inhibitor technique.
Topics: Albumins; Blood Grouping and Crossmatching; Bromelains; Caseins; Cysteine Endopeptidases; Evaluation Studies as Topic; Ficain; Immunoenzyme Techniques; Leucine; Papain; Substrate Specificity | 1989 |
Mode of binding of E-64-c, a potent thiol protease inhibitor, to papain as determined by X-ray crystal analysis of the complex.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Computer Graphics; Hydrogen Bonding; Leucine; Papain; Protease Inhibitors; Protein Conformation; Software; X-Ray Diffraction | 1989 |
Cleavage site of calcium-dependent protease in human platelet membrane glycoprotein Ib.
Topics: Animals; Calcimycin; Calcium; Calpain; Chickens; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Humans; Isoelectric Point; Leucine; Leupeptins; Membrane Proteins; Molecular Weight; Phenotype; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Platelet Membrane Glycoproteins | 1986 |
Cathepsin L--a latent proteinase in guinea pig sperm.
Topics: Animals; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Dithiothreitol; Endopeptidases; Guinea Pigs; Hydrogen-Ion Concentration; Kinetics; Leucine; Leupeptins; Male; Mercuric Chloride; Protease Inhibitors; Spermatozoa | 1988 |
Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid-dependent mechanism.
Topics: Acidosis; Adrenalectomy; Ammonium Chloride; Animals; Body Weight; Dexamethasone; Hydrogen-Ion Concentration; In Vitro Techniques; Indomethacin; Insulin; Leucine; Male; Muscle Proteins; Muscles; Nitrogen; Protease Inhibitors; Rats; Rats, Inbred Strains | 1986 |
Induction and inhibition of cathepsin B and hemoglobin-hydrolase activity in murine B16 melanoma by thiol protease inhibitors.
Topics: Animals; Antipain; Cathepsin B; Kinetics; Leucine; Leupeptins; Melanoma, Experimental; Mice; Oligopeptides; Peptide Hydrolases; Protease Inhibitors | 1986 |
Autodegradation of lysosomal cysteine proteinases.
Topics: Animals; Cathepsins; Cysteine Endopeptidases; Endopeptidases; Hydrolases; Kinetics; Leucine; Liver; Lysosomes; Male; Protease Inhibitors; Rats; Rats, Inbred Strains | 1987 |
Isolation of two forms of the high-molecular-mass serine protease, ingensin, from porcine skeletal muscle.
Topics: Animals; Antipain; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, High Pressure Liquid; Coumarins; Cysteine Endopeptidases; Endopeptidases; Isoenzymes; Leucine; Leupeptins; Multienzyme Complexes; Muscles; Oligopeptides; Pepstatins; Proteasome Endopeptidase Complex; Sodium Dodecyl Sulfate; Swine | 1985 |
The effect of an in vivo-injected thiol protease inhibitor, E-64-c, on the calcium-induced degeneration of myofilaments.
Topics: Actinin; Animals; Calcium; Calpain; Cathepsin B; Cathepsins; Cytosol; Endopeptidases; Leucine; Muscles; Protease Inhibitors; Rats | 1981 |
Relation between in vivo effects and in vitro effects of serine and thiol proteinase inhibitors.
Topics: Animals; Endopeptidases; In Vitro Techniques; Kidney; Leucine; Leupeptins; Liver; Male; Mice; Mice, Inbred ICR; Muscles; Myocardium; Protease Inhibitors; Spleen | 1983 |
The role of increased proteolysis in the atrophy and arrest of proliferation in serum-deprived fibroblasts.
Topics: Animals; Cell Cycle; Cells, Cultured; Culture Media; Fibroblasts; Growth Substances; Leucine; Lysosomes; Mice; Mice, Inbred BALB C; Nucleic Acids; Peptide Hydrolases; Proteins | 1984 |
Two-step mechanism of myofibrillar protein degradation in acute plasmocid-induced muscle necrosis.
Topics: Actinin; Aminoquinolines; Animals; Egtazic Acid; Leucine; Lysosomes; Male; Muscle Proteins; Muscles; Necrosis; Phagocytosis; Protease Inhibitors; Rats; Rats, Inbred Strains | 1984 |
Suppression of calcium-induced removal of the Z-line by a thiol-protease inhibitor, E-64-c.
Topics: Animals; Calcimycin; Calcium; Leucine; Muscles; Myofibrils; Rats | 1981 |
Limited benefit to genetically dystrophic chickens from a synthetic proteinase inhibitor: Ep475.
Topics: Animals; Calcium; Chickens; Creatine Kinase; Leucine; Motor Activity; Muscle Proteins; Muscles; Muscular Dystrophy, Animal; Pectoralis Muscles; Protease Inhibitors | 1983 |
Effects of cathepsin B, H, and D in pectoral muscle of dystrophic chickens (line 413) of in vivo administration of E-64-c (N-[N-(L-3-transcarboxyoxirane-2-carbonyl)-L-leucyl]-3-methyl-butylamine).
Topics: Animals; Cathepsin B; Cathepsin D; Cathepsin H; Cathepsins; Chickens; Cysteine Endopeptidases; Leucine; Muscles; Muscular Dystrophy, Animal; Protease Inhibitors | 1981 |
m-calpain in rat growth plate chondrocyte cultures: its involvement in the matrix mineralization process.
Topics: Alkaline Phosphatase; Animals; Calcification, Physiologic; Calcium; Calcium-Binding Proteins; Calpain; Cell Differentiation; Cells, Cultured; Cysteine Proteinase Inhibitors; DNA; Extracellular Matrix; Growth Plate; Leucine; Male; Proteoglycans; Rats; Rats, Wistar; Uronic Acids | 1995 |
Both cathepsin B and cathepsin D are necessary for processing of ovalbumin as well as for degradation of class II MHC invariant chain.
Topics: Animals; Antigen Presentation; Antigen-Presenting Cells; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Cathepsin B; Cathepsin D; Cell Line; Cysteine Proteinase Inhibitors; Dipeptides; Histocompatibility Antigens Class II; Humans; Interleukin-2; Leucine; Major Histocompatibility Complex; Mice; Ovalbumin; Pepstatins; T-Lymphocytes, Helper-Inducer; Tumor Cells, Cultured | 1994 |
Effect of Ep475 on changes induced by calcium activated neutral protease on erythrocyte membrane.
Topics: Calpain; Cysteine Proteinase Inhibitors; Erythrocyte Membrane; Humans; Leucine | 1994 |
Retraction of cultured endothelial cell monolayer by human breast cancer cells, MCF-7.
Topics: Breast Neoplasms; Cell Adhesion; Cell Communication; Cell Line; Culture Media, Conditioned; Endothelium, Vascular; Estradiol; Glycopeptides; Glycoproteins; Humans; Leucine; Medroxyprogesterone Acetate; Metalloendopeptidases; Microscopy, Phase-Contrast; Progesterone; Protease Inhibitors; Receptors, Progesterone; Tamoxifen; Tissue Inhibitor of Metalloproteinases; Trypsin; Tumor Cells, Cultured | 1993 |
Determination of a cysteine protease inhibitor and its ethyl ester in mouse serum and muscle by liquid chromatography-mass spectrometry.
Topics: Animals; Atmospheric Pressure; Chromatography, High Pressure Liquid; Cysteine Proteinase Inhibitors; Esters; Leucine; Male; Mass Spectrometry; Methanol; Mice; Mice, Inbred C57BL; Muscles; Trichloroacetic Acid | 1993 |
The inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by cysteine endopeptidase inactivators.
Topics: Animals; Cartilage; Cathepsins; Cattle; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dinoprostone; Humans; Interleukin-1; Interleukin-6; Leucine; Nasal Septum; Proteoglycans; Signal Transduction | 1993 |
A calcium stimulated cysteine protease involved in isoproterenol induced cardiac hypertrophy.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Calpain; Cardiomegaly; Cyclic AMP; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Isoproterenol; Leucine; Male; Rats; Rats, Wistar; RNA; Ventricular Function, Left | 1997 |
Striated muscle calcium-stimulated cysteine protease (calpain-like) activity promotes myeloperoxidase activity with exercise.
Topics: Animals; Calpain; Creatine Kinase; Cysteine Proteinase Inhibitors; Leucine; Male; Muscle, Skeletal; Myocardium; Neutrophils; Peroxidase; Physical Exertion; Rats; Rats, Wistar | 1998 |
Participation of intracellular cysteine proteinases, in particular cathepsin B, in degradation of collagen in periosteal tissue explants.
Topics: Animals; Cathepsin B; Cathepsin L; Cathepsins; Collagen; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Hydroxyproline; Leucine; Organ Culture Techniques; Periosteum; Phagocytosis; Rabbits; Skull; Substrate Specificity; Vacuoles | 1998 |
Postictal blockade of ischemic hippocampal neuronal death in primates using selective cathepsin inhibitors.
Topics: Animals; Brain Ischemia; Cathepsin B; Cathepsin L; Cathepsins; Cell Count; Cell Death; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; Endopeptidases; Hippocampus; Immunohistochemistry; Leucine; Macaca | 1999 |
Calpain-calpastatin: a novel, complete calcium-dependent protease system in human spermatozoa.
Topics: Calcium; Calcium-Binding Proteins; Calpain; Cysteine Proteinase Inhibitors; Cytosol; Humans; Hydrogen-Ion Concentration; Immunoblotting; Leucine; Male; Semen; Spermatozoa; Time Factors | 1999 |
Structural basis for development of cathepsin B-specific noncovalent-type inhibitor: crystal structure of cathepsin B-E64c complex.
Topics: Animals; Cathepsin B; Cattle; Crystallography, X-Ray; Cysteine Proteinase Inhibitors; Dipeptides; Drug Design; In Vitro Techniques; Leucine; Macromolecular Substances; Models, Molecular; Protein Conformation; Static Electricity; Substrate Specificity; Thermodynamics | 2002 |
Primate neurons show different vulnerability to transient ischemia and response to cathepsin inhibition.
Topics: Animals; Calpain; Cathepsin B; Cell Survival; Cysteine Proteinase Inhibitors; Dipeptides; Ischemic Attack, Transient; Leucine; Macaca; Necrosis; Nerve Degeneration; Neuroprotective Agents | 2002 |
Differential effects of calpain inhibitors on hypertrophy of cardiomyocytes.
Topics: Acrylates; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Calpain; Cardiomegaly; Cells, Cultured; Cysteine Proteinase Inhibitors; Glycoproteins; Heart Ventricles; Leucine; Myocytes, Cardiac; Phenylephrine; Rats; Time Factors; Ventricular Function, Left | 2003 |
Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cells, Cultured; Chromaffin Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dithiothreitol; Endopeptidases; Extracellular Space; Glutathione; Leucine; Mice; Mice, Knockout; Mutation; Neurons; Nicotine; Nicotinic Agonists; Peptide Fragments; Potassium Chloride; Secretory Vesicles; Substrate Specificity; Time Factors | 2003 |
Crystal structures of calpain-E64 and -leupeptin inhibitor complexes reveal mobile loops gating the active site.
Topics: Amino Acid Sequence; Animals; Calpain; Catalytic Domain; Cathepsin K; Cathepsins; Crystallization; Crystallography, X-Ray; Cysteine Proteinase Inhibitors; Glycoproteins; Leucine; Leupeptins; Molecular Sequence Data; Papain; Protein Structure, Tertiary; Rats | 2004 |
Involvement of calpain in osteoclastic bone resorption.
Topics: Actins; Aged; Bone and Bones; Bone Resorption; Calpain; Cells, Cultured; Dipeptides; Humans; Leucine; Osteoclasts; Recombinant Fusion Proteins; Talin | 2005 |
Effect of cysteine protease inhibitor Ep-475 on TNF-alpha-independent cyclophosphamide-induced apoptosis in mouse lymphosarcoma LS cells.
Topics: Animals; Apoptosis; Cathepsin B; Cathepsin L; Cathepsins; Cyclophosphamide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Leucine; Lymphoma, Non-Hodgkin; Male; Mice; Mice, Inbred CBA; Tumor Necrosis Factor-alpha | 2005 |
A homologue of cathepsin L identified in conditioned medium from Sf9 insect cells.
Topics: Animals; Cathepsin L; Cathepsins; Cells, Cultured; Culture Media, Conditioned; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Gelatin; Hydrogen-Ion Concentration; Leucine; Spodoptera | 2006 |
Relative contribution of matrix metalloprotease and cysteine protease activities to cytokine-stimulated articular cartilage degradation.
Topics: Animals; Arthritis, Experimental; Biomarkers; Cartilage, Articular; Cathepsin K; Cathepsins; Cattle; Collagen Type I; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytokines; Dipeptides; Extracellular Matrix; Glycosaminoglycans; Hydroxyproline; Immunohistochemistry; Leucine; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Knockout; Oncostatin M; Osteoarthritis, Knee; Peptides; Stimulation, Chemical; Tissue Culture Techniques; Tumor Necrosis Factor-alpha | 2006 |
Cathepsin L plays an important role in the lysosomal degradation of L-lactate dehydrogenase.
Topics: Amino Acid Sequence; Animals; Cathepsin L; Cathepsins; Chromatography, Gel; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; L-Lactate Dehydrogenase; Leucine; Leupeptins; Lysosomes; Male; Molecular Sequence Data; Rats; Rats, Wistar; Sequence Alignment | 2006 |
Involvement of calpain and synaptotagmin Ca2+ sensors in hormone secretion from excitable endocrine cells.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Apoptosis; Blotting, Western; Calcium; Calcium Signaling; Calpain; Cell Line; Cysteine Proteinase Inhibitors; Endocrine Glands; Flow Cytometry; Growth Hormone; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Pituitary Gland; Stimulation, Chemical; Synaptotagmins | 2006 |
Environmental effects on charge densities of biologically active molecules: do molecule crystal environments indeed approximate protein surroundings?
Topics: Computer Simulation; Crystallization; Crystallography, X-Ray; Cysteine Endopeptidases; Humans; Kringles; Leucine; Ligands; Models, Chemical; Models, Molecular; Molecular Conformation; Plasminogen; Quantum Theory; Static Electricity; Tranexamic Acid | 2009 |
Autophagy in tobacco BY-2 cells cultured under sucrose starvation conditions: isolation of the autolysosome and its characterization.
Topics: Adenine; Autophagy; Blotting, Western; Cell Fractionation; Cells, Cultured; Cysteine Proteases; Endocytosis; Fluorescent Antibody Technique; Leucine; Lysosomes; Nicotiana; Plant Proteins; Staining and Labeling; Sucrose | 2011 |
E-64c-hydrazide: a lead structure for the development of irreversible cathepsin C inhibitors.
Topics: Binding Sites; Catalytic Domain; Cathepsin C; Crystallography, X-Ray; Hydrazines; Hydrophobic and Hydrophilic Interactions; Kinetics; Leucine; Protease Inhibitors; Structure-Activity Relationship | 2013 |
Dissection of autophagy in tobacco BY-2 cells under sucrose starvation conditions using the vacuolar H(+)-ATPase inhibitor concanamycin A and the autophagy-related protein Atg8.
Topics: Adenine; Autophagy; Cells, Cultured; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Fluorescence; Green Fluorescent Proteins; Hydrogen-Ion Concentration; Intracellular Membranes; Leucine; Lysosomes; Macrolides; Nicotiana; Phagosomes; Plant Proteins; Proteolysis; Recombinant Fusion Proteins; Sucrose; Vacuolar Proton-Translocating ATPases; Vacuoles | 2015 |
Isolation of Autolysosomes from Tobacco BY-2 Cells.
Topics: Acid Phosphatase; Autophagy; Biomarkers; Cell Culture Techniques; Cell Fractionation; Centrifugation, Density Gradient; Culture Media; Cysteine Proteinase Inhibitors; Leucine; Lysosomes; Mitochondria; Nicotiana; Peptide Hydrolases; Peroxisomes; Plant Cells; Plant Proteins; Proteolysis; Sucrose; Vacuolar Proton-Translocating ATPases; Vacuoles | 2017 |
E-64c-Hydrazide Based Cathepsin C Inhibitors: Optimizing the Interactions with the S1'-S2' Area.
Topics: Cathepsin C; Hydrazines; Leucine; Leukocyte Elastase; Serine Proteases | 2023 |