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n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine and calpain

n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine has been researched along with calpain in 16 studies

Compound Research Comparison

Studies
(n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine)
Trials
(n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine)
Recent Studies (post-2010)
(n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine)
Studies
(calpain)
Trials
(calpain)
Recent Studies (post-2010) (calpain)
791167,019252,422

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19904 (25.00)18.7374
1990's7 (43.75)18.2507
2000's5 (31.25)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Detwiler, TC; Huang, Z; McGowan, EB1
Inuzuka, T; Kirino, T; Miyatake, T; Sato, S; Tamura, A; Toyoshima, I1
Kakkar, VV; Krishnamurthi, S; Patel, Y; Sadowska, K; Wheeler-Jones, CP1
Fujihara, M; Hoshino, N; Kimura, I; Kimura, M; Kobayashi, S1
Kosaki, G; Suzuki, K; Tanoue, K; Yamamoto, K; Yamazaki, H1
Hanada, K; Ishiura, S; Kashiwagi, K; Sugita, H; Tamai, M1
Nakagawa, Y; Niibayashi, H; Shimizu, K; Yamamoto, S; Yamamuro, T; Yasuda, T1
Anandaraj, MP; Devi, CV1
Arthur, GD; Belcastro, AN1
Belcastro, AN; Booker, TS; Raj, DA1
Brush, M; Moretti-Rojas, I; Rojas, FJ1
Kohda, Y; Kominami, E; Matsuda, M; Tonchev, AB; Tsuchiya, K; Yamashima, T; Yoshida, M; Zhao, L1
Pollack, JR; Sugimoto, JT; Witt, RC1
Campbell, RL; Cuerrier, D; Davies, PL; Moldoveanu, T1
Hayashi, M; Inomata, M; Ishibashi, H; Kawashima, S; Koshihara, Y; Saido, TC; Tsubuki, S; Yamamoto, S1
Aganna, E; Burrin, JM; Hitman, GA; Turner, MD1

Other Studies

16 other study(ies) available for n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine and calpain

ArticleYear
Ester and amide derivatives of E64c as inhibitors of platelet calpains.
    Journal of medicinal chemistry, 1992, May-29, Volume: 35, Issue:11

    Topics: Adult; Blood Platelets; Calcimycin; Calcium; Calpain; Cysteine Proteinase Inhibitors; Esters; Humans; Leucine; Serotonin; Structure-Activity Relationship

1992
Suppressive effect of E-64c on ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats.
    Brain research, 1990, Aug-27, Volume: 526, Issue:1

    Topics: Animals; Calpain; Cerebral Arteries; Immunoblotting; Ischemic Attack, Transient; Leucine; Male; Microtubule-Associated Proteins; Myelin Proteins; Myelin-Associated Glycoprotein; Rats; Rats, Inbred Strains

1990
Effects of the calpain inhibitor E64-d on platelet activation responses.
    British journal of pharmacology, 1989, Volume: 98 Suppl

    Topics: Calpain; Cysteine Proteinase Inhibitors; Humans; In Vitro Techniques; Leucine; Platelet Activation

1989
Diabetic state-induced activation of calcium-activated neutral proteinase in mouse skeletal muscle.
    Endocrinologia japonica, 1989, Volume: 36, Issue:6

    Topics: Actinin; Animals; Calcium; Calpain; Cell Membrane; Creatine Kinase; Cysteine Proteinase Inhibitors; Diabetes Mellitus, Experimental; Edetic Acid; Egtazic Acid; Electrophoresis; Enzyme Activation; Leucine; Male; Mice; Muscles

1989
Cleavage site of calcium-dependent protease in human platelet membrane glycoprotein Ib.
    Thrombosis research, 1986, Jul-01, Volume: 43, Issue:1

    Topics: Animals; Calcimycin; Calcium; Calpain; Chickens; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Humans; Isoelectric Point; Leucine; Leupeptins; Membrane Proteins; Molecular Weight; Phenotype; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Platelet Membrane Glycoproteins

1986
The effect of an in vivo-injected thiol protease inhibitor, E-64-c, on the calcium-induced degeneration of myofilaments.
    Journal of biochemistry, 1981, Volume: 90, Issue:5

    Topics: Actinin; Animals; Calcium; Calpain; Cathepsin B; Cathepsins; Cytosol; Endopeptidases; Leucine; Muscles; Protease Inhibitors; Rats

1981
m-calpain in rat growth plate chondrocyte cultures: its involvement in the matrix mineralization process.
    Developmental biology, 1995, Volume: 170, Issue:1

    Topics: Alkaline Phosphatase; Animals; Calcification, Physiologic; Calcium; Calcium-Binding Proteins; Calpain; Cell Differentiation; Cells, Cultured; Cysteine Proteinase Inhibitors; DNA; Extracellular Matrix; Growth Plate; Leucine; Male; Proteoglycans; Rats; Rats, Wistar; Uronic Acids

1995
Effect of Ep475 on changes induced by calcium activated neutral protease on erythrocyte membrane.
    Indian journal of experimental biology, 1994, Volume: 32, Issue:7

    Topics: Calpain; Cysteine Proteinase Inhibitors; Erythrocyte Membrane; Humans; Leucine

1994
A calcium stimulated cysteine protease involved in isoproterenol induced cardiac hypertrophy.
    Molecular and cellular biochemistry, 1997, Volume: 176, Issue:1-2

    Topics: Adrenergic beta-Agonists; Animals; Calcium; Calpain; Cardiomegaly; Cyclic AMP; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Isoproterenol; Leucine; Male; Rats; Rats, Wistar; RNA; Ventricular Function, Left

1997
Striated muscle calcium-stimulated cysteine protease (calpain-like) activity promotes myeloperoxidase activity with exercise.
    Pflugers Archiv : European journal of physiology, 1998, Volume: 435, Issue:6

    Topics: Animals; Calpain; Creatine Kinase; Cysteine Proteinase Inhibitors; Leucine; Male; Muscle, Skeletal; Myocardium; Neutrophils; Peroxidase; Physical Exertion; Rats; Rats, Wistar

1998
Calpain-calpastatin: a novel, complete calcium-dependent protease system in human spermatozoa.
    Molecular human reproduction, 1999, Volume: 5, Issue:6

    Topics: Calcium; Calcium-Binding Proteins; Calpain; Cysteine Proteinase Inhibitors; Cytosol; Humans; Hydrogen-Ion Concentration; Immunoblotting; Leucine; Male; Semen; Spermatozoa; Time Factors

1999
Primate neurons show different vulnerability to transient ischemia and response to cathepsin inhibition.
    Acta neuropathologica, 2002, Volume: 104, Issue:3

    Topics: Animals; Calpain; Cathepsin B; Cell Survival; Cysteine Proteinase Inhibitors; Dipeptides; Ischemic Attack, Transient; Leucine; Macaca; Necrosis; Nerve Degeneration; Neuroprotective Agents

2002
Differential effects of calpain inhibitors on hypertrophy of cardiomyocytes.
    Molecular and cellular biochemistry, 2003, Volume: 251, Issue:1-2

    Topics: Acrylates; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Calpain; Cardiomegaly; Cells, Cultured; Cysteine Proteinase Inhibitors; Glycoproteins; Heart Ventricles; Leucine; Myocytes, Cardiac; Phenylephrine; Rats; Time Factors; Ventricular Function, Left

2003
Crystal structures of calpain-E64 and -leupeptin inhibitor complexes reveal mobile loops gating the active site.
    Journal of molecular biology, 2004, Nov-05, Volume: 343, Issue:5

    Topics: Amino Acid Sequence; Animals; Calpain; Catalytic Domain; Cathepsin K; Cathepsins; Crystallization; Crystallography, X-Ray; Cysteine Proteinase Inhibitors; Glycoproteins; Leucine; Leupeptins; Molecular Sequence Data; Papain; Protein Structure, Tertiary; Rats

2004
Involvement of calpain in osteoclastic bone resorption.
    Journal of biochemistry, 2005, Volume: 137, Issue:3

    Topics: Actins; Aged; Bone and Bones; Bone Resorption; Calpain; Cells, Cultured; Dipeptides; Humans; Leucine; Osteoclasts; Recombinant Fusion Proteins; Talin

2005
Involvement of calpain and synaptotagmin Ca2+ sensors in hormone secretion from excitable endocrine cells.
    The Journal of endocrinology, 2006, Volume: 190, Issue:3

    Topics: Adrenocorticotropic Hormone; Analysis of Variance; Apoptosis; Blotting, Western; Calcium; Calcium Signaling; Calpain; Cell Line; Cysteine Proteinase Inhibitors; Endocrine Glands; Flow Cytometry; Growth Hormone; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Pituitary Gland; Stimulation, Chemical; Synaptotagmins

2006