n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine has been researched along with aloxistatin in 10 studies
| Studies (n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine) | Trials (n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine) | Recent Studies (post-2010) (n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine) | Studies (aloxistatin) | Trials (aloxistatin) | Recent Studies (post-2010) (aloxistatin) |
|---|---|---|---|---|---|
| 79 | 1 | 16 | 153 | 1 | 38 |
| Protein | Taxonomy | n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine (IC50) | aloxistatin (IC50) |
|---|---|---|---|
| calpain II, partial | Sus scrofa (pig) | 1.7742 | |
| Calpain-1 catalytic subunit | Homo sapiens (human) | 4 | |
| Procathepsin L | Homo sapiens (human) | 2.41 | |
| Cathepsin G | Homo sapiens (human) | 1.1 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Detwiler, TC; Huang, Z; McGowan, EB | 1 |
| Meara, JP; Rich, DH | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Kabir, M; Kerns, E; Nguyen, K; Shah, P; Sun, H; Wang, Y; Xu, X; Yu, KR | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Barrett, AJ; Buttle, DJ; Saklatvala, J; Tamai, M | 1 |
| Barrett, AJ; Buttle, DJ; Saklatvala, J | 1 |
| Beertsen, W; Buttle, DJ; Creemers, LB; Everts, V; Hoeben, KA; Jansen, DC | 1 |
| Arnone, M; Engels, B; Fink, RF; Mladenovic, M | 1 |
10 other study(ies) available for n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine and aloxistatin
| Article | Year |
|---|---|
Ester and amide derivatives of E64c as inhibitors of platelet calpains.
Topics: Adult; Blood Platelets; Calcimycin; Calcium; Calpain; Cysteine Proteinase Inhibitors; Esters; Humans; Leucine; Serotonin; Structure-Activity Relationship | 1992 |
Mechanistic studies on the inactivation of papain by epoxysuccinyl inhibitors.
Topics: Cysteine Proteinase Inhibitors; Epoxy Compounds; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Molecular Structure; Papain; Structure-Activity Relationship; Succinates | 1996 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Predictive models of aqueous solubility of organic compounds built on A large dataset of high integrity.
Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility | 2019 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by a lipophilic inactivator of cysteine endopeptidases.
Topics: Animals; Cartilage; Cattle; Cysteine Proteinase Inhibitors; Interleukin-1; Iodoacetates; Iodoacetic Acid; Leucine; Proteoglycans; Recombinant Proteins | 1992 |
The inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by cysteine endopeptidase inactivators.
Topics: Animals; Cartilage; Cathepsins; Cattle; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dinoprostone; Humans; Interleukin-1; Interleukin-6; Leucine; Nasal Septum; Proteoglycans; Signal Transduction | 1993 |
Participation of intracellular cysteine proteinases, in particular cathepsin B, in degradation of collagen in periosteal tissue explants.
Topics: Animals; Cathepsin B; Cathepsin L; Cathepsins; Collagen; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Hydroxyproline; Leucine; Organ Culture Techniques; Periosteum; Phagocytosis; Rabbits; Skull; Substrate Specificity; Vacuoles | 1998 |
Environmental effects on charge densities of biologically active molecules: do molecule crystal environments indeed approximate protein surroundings?
Topics: Computer Simulation; Crystallization; Crystallography, X-Ray; Cysteine Endopeptidases; Humans; Kringles; Leucine; Ligands; Models, Chemical; Models, Molecular; Molecular Conformation; Plasminogen; Quantum Theory; Static Electricity; Tranexamic Acid | 2009 |