n-(4-isothiocyanatophenethyl)spiperone has been researched along with spiperone in 6 studies
*Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA. [MeSH]
*Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA. [MeSH]
| Studies (n-(4-isothiocyanatophenethyl)spiperone) | Trials (n-(4-isothiocyanatophenethyl)spiperone) | Recent Studies (post-2010) (n-(4-isothiocyanatophenethyl)spiperone) | Studies (spiperone) | Trials (spiperone) | Recent Studies (post-2010) (spiperone) |
|---|---|---|---|---|---|
| 7 | 0 | 1 | 2,944 | 13 | 85 |
| Protein | Taxonomy | n-(4-isothiocyanatophenethyl)spiperone (IC50) | spiperone (IC50) |
|---|---|---|---|
| Bile salt export pump | Homo sapiens (human) | 10 | |
| D(2) dopamine receptor | Homo sapiens (human) | 0.0008 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.097 | |
| D(4) dopamine receptor | Homo sapiens (human) | 0.0005 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 0.097 | |
| Histamine H1 receptor | Cavia porcellus (domestic guinea pig) | 0.097 | |
| D(3) dopamine receptor | Homo sapiens (human) | 0.0635 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.097 | |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | 0.0001 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.955 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Black, LE; Creese, I; Hatada, Y; Sibley, DR; Xu, SX | 1 |
| Baldessarini, RJ; Kula, NS; Neumeyer, JL; Tarazi, FI; Zhang, K | 1 |
| Baldessarini, RJ; Kula, NS; Tarazi, FI; Weiss, NT; Zhang, K | 1 |
| Ferré, S; Finnman, UB; Fuxe, K; Owman, C; Rinken, A; Terasmaa, A | 1 |
| Bridges, SR; Thompson, TL; Weirs, WJ | 1 |
| Certain, ME; Thompson, TL | 1 |
6 other study(ies) available for n-(4-isothiocyanatophenethyl)spiperone and spiperone
| Article | Year |
|---|---|
N-(p-isothiocyanatophenethyl)spiperone, a selective and irreversible antagonist of D2 dopamine receptors in brain.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Cells, Cultured; Dopamine Antagonists; Injections, Subcutaneous; Male; Quinolines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1991 |
Selective alkylatation of dopamine D2 and D4 receptors in rat brain by N-(p-isothiocyanatophenethyl)spiperone.
Topics: Alkylation; Animals; Autoradiography; Brain Chemistry; Dopamine Antagonists; Male; Neostriatum; Nucleus Accumbens; Quinolines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4; Receptors, Serotonin; Spiperone | 1999 |
Effects of alkylating agents on dopamine D(3) receptors in rat brain: selective protection by dopamine.
Topics: Alkylating Agents; Animals; Brain; Dopamine; Dopamine Antagonists; Male; Neuroprotective Agents; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Spiperone | 1999 |
Modulation of [(35)S]GTPgammaS binding to chinese hamster ovary cell membranes by D(2(short)) dopamine receptors.
Topics: Animals; Binding, Competitive; Butaclamol; CHO Cells; Cricetinae; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Membranes; Raclopride; Radioligand Assay; Rats; Receptors, Dopamine D2; Spiperone; Sulfur Radioisotopes; Tritium | 2000 |
Alteration of dopamine transport in the striatum and nucleus accumbens of ovariectomized and estrogen-primed rats following N-(p-isothiocyanatophenethyl) spiperone (NIPS) treatment.
Topics: Animals; Carrier Proteins; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dopamine Plasma Membrane Transport Proteins; Drug Interactions; Estrogens; Estrus; Female; Guanosine 5'-O-(3-Thiotriphosphate); Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Nucleus Accumbens; Ovariectomy; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Spiperone; Sulfur Radioisotopes; Synaptosomes; Tritium | 2001 |
Estrogen mediated inhibition of dopamine transport in the striatum: regulation by G alpha i/o.
Topics: Adenosine Diphosphate Ribose; Animals; Biological Transport; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Estrogens; Female; GTP-Binding Protein alpha Subunits, Gi-Go; Ovariectomy; Pertussis Toxin; Phosphorus Radioisotopes; Rats; Rats, Sprague-Dawley; Spiperone; Synaptosomes | 2005 |