n-(4,4-diphenyl-3-butenyl)nipecotic acid has been researched along with nipecotic acid in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.00) | 18.7374 |
| 1990's | 8 (40.00) | 18.2507 |
| 2000's | 3 (15.00) | 29.6817 |
| 2010's | 6 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ali, FE; Bondinell, WE; Dandridge, PA; Frazee, JS; Garvey, E; Girard, GR; Kaiser, C; Ku, TW; Lafferty, JJ; Moonsammy, GI | 1 |
| Kehler, J; Krogsgaard-Larsen, P; Stensbøl, TB | 1 |
| Höfner, G; Kragler, A; Wanner, KT | 1 |
| Faust, MR; Höfner, G; Pabel, J; Wanner, KT | 1 |
| Lutz, TA; Petrera, M; Sindelar, M; Wanner, KT | 1 |
| Allmendinger, L; Fülep, G; Höfner, G; Sitka, I; Wanner, KT | 1 |
| Hellenbrand, T; Höfner, G; Wanner, KT; Wein, T | 1 |
| Kern, F; Wanner, KT | 1 |
| Masland, RH; O'Malley, DM; Sandell, JH | 1 |
| Gordon-Weeks, PR; Taylor, J | 1 |
| Andrioli, GC; Bonanno, G; Raiteri, M; Ruelle, A | 1 |
| Bonanno, G; Fedele, E; Fontana, G; Raiteri, M; Robino, G | 1 |
| Falch, E; Krogsgaard-Larsen, P; Larsson, OM; Schousboe, A | 1 |
| Copenhagen, DR; Kaneko, A; Miyoshi, S; Takahashi, K | 1 |
| Nicklas, WJ; Zeevalk, GD | 1 |
| Arias-Montaño, JA; Bahena-Trujillo, R | 1 |
| Bernard, LP; Nicklas, WJ; Stokes, AH; Zeevalk, GD | 1 |
| Richerson, GB; Wang, W; Wu, Y | 1 |
| Allen, CN; Cravetchi, O; Moldavan, M | 1 |
| Brahce, L; Gregor, VE; Lobbestael, SJ; Mayhugh, DR; Nugiel, D; Pavia, MR; Schwarz, RD; Taylor, CP; Vartanian, MG | 1 |
20 other study(ies) available for n-(4,4-diphenyl-3-butenyl)nipecotic acid and nipecotic acid
| Article | Year |
|---|---|
Orally active and potent inhibitors of gamma-aminobutyric acid uptake.
Topics: 4-Aminobutyrate Transaminase; Administration, Oral; Alkylation; Amino Acids; Animals; Brain; Carboxylic Acids; gamma-Aminobutyric Acid; Glutamate Decarboxylase; In Vitro Techniques; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Neurotransmitter; Stereoisomerism; Synaptosomes | 1985 |
Piperidinyl-3-phosphinic acids as novel uptake inhibitors of the neurotransmitter gamma-aminobutyric acid (GABA).
Topics: Animals; Brain; GABA Antagonists; Inhibitory Concentration 50; Models, Chemical; Neurotransmitter Uptake Inhibitors; Phosphinic Acids; Piperidines; Rats; Synaptosomes | 1999 |
Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4.
Topics: Animals; Benzylamines; Cell Line; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Humans; Methylation; Mice; Molecular Structure; Structure-Activity Relationship | 2008 |
Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship.
Topics: Animals; Azetidines; Biological Transport; Cattle; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Inhibitory Concentration 50; Structure-Activity Relationship | 2010 |
Focused pseudostatic hydrazone libraries screened by mass spectrometry binding assay: optimizing affinities toward γ-aminobutyric acid transporter 1.
Topics: GABA Plasma Membrane Transport Proteins; Hydrazones; Mass Spectrometry | 2013 |
Synthesis of N-substituted acyclic β-amino acids and their investigation as GABA uptake inhibitors.
Topics: Amino Acids; Animals; Brain; GABA Plasma Membrane Transport Proteins; HEK293 Cells; Humans; Molecular Structure; Swine | 2013 |
Synthesis of 4-substituted nipecotic acid derivatives and their evaluation as potential GABA uptake inhibitors.
Topics: Drug Evaluation, Preclinical; GABA Uptake Inhibitors; Nipecotic Acids | 2016 |
Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors γ-aminobutyric acid transporter 1.
Topics: Binding Sites; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; HEK293 Cells; Humans; Mass Spectrometry; Molecular Structure; N-Acetylglucosaminyltransferases; Oximes; Small Molecule Libraries; Structure-Activity Relationship | 2019 |
Co-release of acetylcholine and GABA by the starburst amacrine cells.
Topics: Acetylcholine; Animals; Autoradiography; Drug Carriers; GABA Antagonists; gamma-Aminobutyric Acid; Nipecotic Acids; Proline; Retina | 1992 |
Calcium-independent gamma-aminobutyric acid release from growth cones: role of gamma-aminobutyric acid transport.
Topics: Animals; Biological Transport; Calcium; Carrier Proteins; Cell Membrane; Diencephalon; Female; gamma-Aminobutyric Acid; Male; Neurons; Nipecotic Acids; Potassium; Proline; Rats; Rats, Inbred Strains; Synaptosomes; Telencephalon | 1991 |
Cholinergic nerve terminals of human cerebral cortex possess a GABA transporter whose activation induces release of acetylcholine.
Topics: Acetylcholine; Anticonvulsants; Baclofen; Bicuculline; Biotransformation; Carrier Proteins; Cerebral Cortex; Choline; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Male; Membrane Proteins; Membrane Transport Proteins; Middle Aged; Muscimol; Nerve Endings; Nerve Tissue Proteins; Nipecotic Acids; Organic Anion Transporters; Parasympathetic Nervous System; Proline; Synaptosomes | 1991 |
Presynaptic mechanisms underlying the gamma-aminobutyric acid-evoked receptor-independent release of [3H]norepinephrine in rat hippocampus.
Topics: Animals; Biomechanical Phenomena; gamma-Aminobutyric Acid; Hippocampus; Male; Nipecotic Acids; Norepinephrine; Proline; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Sodium; Synapses; Tetrodotoxin; Tritium | 1989 |
Kinetic characterization of inhibition of gamma-aminobutyric acid uptake into cultured neurons and astrocytes by 4,4-diphenyl-3-butenyl derivatives of nipecotic acid and guvacine.
Topics: Animals; Anticonvulsants; Astrocytes; Cells, Cultured; Cerebral Cortex; Chemical Phenomena; Chemistry; GABA Antagonists; gamma-Aminobutyric Acid; Mice; Mice, Inbred Strains; Neurons; Nicotinic Acids; Nipecotic Acids; Proline | 1988 |
Actions of nipecotic acid and SKF89976A on GABA transporter in cone-driven horizontal cells dissociated from the catfish retina.
Topics: Animals; Anticonvulsants; Carrier Proteins; Catfishes; Dose-Response Relationship, Drug; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Membrane Proteins; Membrane Transport Proteins; Nipecotic Acids; Organic Anion Transporters; Patch-Clamp Techniques; Proline; Retina | 1995 |
Activity at the GABA transporter contributes to acute cellular swelling produced by metabolic impairment in retina.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Carrier Proteins; Chick Embryo; Culture Techniques; GABA Agonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glycolysis; Iodoacetates; Ischemia; Isoxazoles; Membrane Proteins; Membrane Transport Proteins; Muscimol; Nipecotic Acids; Organic Anion Transporters; Oximes; Proline; Retina | 1997 |
[3H] gamma-aminobutyric acid transport in rat substantia nigra pars reticulata synaptosomes: pharmacological characterization and phorbol ester-induced inhibition.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Basal Ganglia; beta-Alanine; Biological Transport; Carcinogens; Colforsin; Enzyme Inhibitors; GABA Agents; gamma-Aminobutyric Acid; Nipecotic Acids; Proline; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Substantia Nigra; Synaptosomes; Tetradecanoylphorbol Acetate; Tritium | 1999 |
Attenuation of malonate toxicity in primary mesencephalic cultures using the GABA transport blocker, NO-711.
Topics: Animals; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Malonates; Mesencephalon; Muscimol; Neurons; Nipecotic Acids; Oximes; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2001 |
GABA transaminase inhibition induces spontaneous and enhances depolarization-evoked GABA efflux via reversal of the GABA transporter.
Topics: 4-Aminobutyrate Transaminase; Animals; Calcium; Carrier Proteins; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Membrane Proteins; Membrane Transport Proteins; Neural Inhibition; Neurons; Nipecotic Acids; Organic Anion Transporters; Patch-Clamp Techniques; Potassium; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Vigabatrin | 2001 |
GABA transporters regulate tonic and synaptic GABA
Topics: Animals; Anisoles; GABA Antagonists; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; Male; Neurons; Nipecotic Acids; Oximes; Period Circadian Proteins; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Suprachiasmatic Nucleus; Synaptic Potentials | 2017 |
Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptake.
Topics: Administration, Oral; Animals; Anticonvulsants; Benzhydryl Compounds; Blood-Brain Barrier; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Mice; Neurotransmitter Uptake Inhibitors; Nicotinic Acids; Nipecotic Acids; Proline; Rats; Structure-Activity Relationship | 1992 |