n-(4,4-diphenyl-3-butenyl)nipecotic acid has been researched along with gamma-aminobutyric acid in 79 studies
*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]
*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 17 (21.52) | 18.7374 |
1990's | 38 (48.10) | 18.2507 |
2000's | 14 (17.72) | 29.6817 |
2010's | 10 (12.66) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Brahce, L; Gregor, VE; Lobbestael, SJ; Mayhugh, DR; Nugiel, D; Pavia, MR; Schwarz, RD; Taylor, CP; Vartanian, MG | 1 |
Ali, FE; Bondinell, WE; Dandridge, PA; Frazee, JS; Garvey, E; Girard, GR; Kaiser, C; Ku, TW; Lafferty, JJ; Moonsammy, GI | 1 |
Lutz, TA; Petrera, M; Sindelar, M; Wanner, KT | 1 |
Kern, F; Wanner, KT | 1 |
Cunningham, JR; Hutson, PH; Neal, MJ; Semark, JE | 1 |
Beani, L; Bianchi, C; Ferraro, L; Tanganelli, S | 2 |
Davidson, K; Gillies, G | 1 |
Lewin, L; Mattsson, MO; Rassin, DK; Sellström, A | 1 |
Feldtrauer, JJ; Stöcklin, K; Waldmeier, PC | 1 |
Masland, RH; O'Malley, DM; Sandell, JH | 1 |
Lewin, L; Mattsson, MO; Sellström, A | 1 |
Enna, SJ; Ferkany, JW; Karbon, EW | 1 |
Bonanno, G; Fedele, E; Fontana, G; Gemignani, A; Raiteri, M | 2 |
Rassin, D; Sellström, A | 1 |
Dunlop, J; Grieve, A; Griffiths, R; Schousboe, A | 1 |
Huisman, E; Kamphuis, W; Lopes da Silva, FH; Veerman, MJ | 1 |
Gordon-Weeks, PR; Taylor, J | 1 |
Andrioli, GC; Bonanno, G; Raiteri, M; Ruelle, A | 1 |
Bonanno, G; Giralt, MT; Raiteri, M | 1 |
Falch, E; Krogsgaard-Larsen, P | 1 |
Andrioli, GC; Asaro, D; Bonanno, G; Cavazzani, P; Pellegrini, G; Raiteri, M | 1 |
Bonanno, G; Fedele, E; Fontana, G; Raiteri, M; Robino, G | 1 |
Baumann, PA; Feldtrauer, JJ; Waldmeier, PC; Wicki, P | 2 |
Asaro, D; Pellegrini, G; Pittaluga, A; Raiteri, M | 1 |
Haluska, M; Schwark, WS | 2 |
Bonanno, G; Raiteri, M | 4 |
Falch, E; Krogsgaard-Larsen, P; Larsson, OM; Schousboe, A | 1 |
Löscher, W | 1 |
Löscher, W; Schwark, WS | 1 |
Enna, SJ; Zorn, SH | 1 |
Copenhagen, DR; Kaneko, A; Miyoshi, S; Takahashi, K | 1 |
Isaacson, JS; Nicoll, RA; Solís, JM | 1 |
Davidson, N; Labarca, C; Lester, HA; Mager, S; Naeve, J; Quick, M | 1 |
Grahn, B; Lewin, L; Mattsson, MO; Sellström, A | 1 |
Belhage, B; Hansen, GH; Schousboe, A | 1 |
Baumann, PA; Grunenwald, C; Hertz, C; Waldmeier, PC; Wicki, P | 1 |
Cammack, JN; Schwartz, EA | 1 |
Antonelli, T; Ferraro, L; Fuxe, K; O'Connor, WT; Rambert, F; Tanganelli, S | 1 |
Ghijsen, WE; Lopes da Silva, FH; Veenstra, E; Zuiderwijk, M | 1 |
Nicklas, WJ; Zeevalk, GD | 2 |
Chebib, M; Johnston, GA | 1 |
Ghijsen, WE; Zuiderwijk, M | 1 |
Morimoto, K; Sato, H; Suwaki, H; Watanabe, T; Yamamoto, Y | 1 |
Gaspary, HL; Richerson, GB; Wang, W | 1 |
Chandy, G; Hirayama, BA; Loo, DD; Meinild, AK; Wright, EM; Zeuthen, T | 1 |
Bonanno, G; Fassio, A; Raiteri, M; Rossi, F | 1 |
Oliveira, CR; Rego, AC | 1 |
Arias-Montaño, JA; Bahena-Trujillo, R | 1 |
Hiemke, C; Schmitt, U | 1 |
Catsicas, M; Mobbs, P | 1 |
Bernard, LP; Nicklas, WJ; Stokes, AH; Zeevalk, GD | 1 |
Richerson, GB; Wang, W; Wu, Y | 2 |
Aribi, AM; Stringer, JL | 1 |
Chatton, JY; Magistretti, PJ; Pellerin, L | 1 |
Canas, N; Pereira, IT; Ribeiro, JA; Sebastião, AM | 1 |
Bossi, E; Giovannardi, S; Peres, A; Pisani, R; Soragna, A | 1 |
Ackerson, LC; Galvan, A; Maidment, NT; Smith, Y; Villalba, RM; West, SM; Wichmann, T | 1 |
Kullmann, DM; Scimemi, A; Semyanov, A; Sperk, G; Walker, MC | 1 |
Barstead, RJ; Fields, SD; Mathews, EA; McManus, JR; Moulder, G; Mullen, GP; Quick, MW; Rand, JB; Saxena, P | 1 |
Ben-Ari, Y; Chiron, C; Gozlan, H; Quilichini, PP | 1 |
Ghijsen, WE; Lopes da Silva, FH; Zuiderwijk, M | 1 |
Ritta, MN; Tartaglione, CM | 1 |
Gardner, EL; Peng, XQ; Xi, ZX | 1 |
Bonanno, G; Bonifacino, T; Cervetto, C; Jacchetti, E; Milanese, M; Usai, C; Zappettini, S | 1 |
Castagna, M; Sacchi, VF; Santacroce, M | 1 |
Babot, Z; Cristòfol, R; Schousboe, A; Sonnewald, U; Suñol, C; Waagepetersen, HS | 1 |
Balana, B; Dolev, I; Laviv, T; Riven, I; Slesinger, PA; Slutsky, I; Vertkin, I | 1 |
Brugarolas, M; Casadó, V; Conti, F; Cristóvão-Ferreira, S; Fattorini, G; Franco, R; Lluis, C; McCormick, PJ; Navarro, G; Pérez-Capote, K; Ribeiro, JA; Sebastião, AM; Vaz, SH | 1 |
Binda, NS; Costa, FL; Diniz, PH; Gomez, MV; Gomez, RS; Guatimosim, C | 1 |
Milanese, M; Oliveri, M; Raiteri, L; Romei, C; Usai, C | 1 |
79 other study(ies) available for n-(4,4-diphenyl-3-butenyl)nipecotic acid and gamma-aminobutyric acid
Article | Year |
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Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptake.
Topics: Administration, Oral; Animals; Anticonvulsants; Benzhydryl Compounds; Blood-Brain Barrier; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Mice; Neurotransmitter Uptake Inhibitors; Nicotinic Acids; Nipecotic Acids; Proline; Rats; Structure-Activity Relationship | 1992 |
Orally active and potent inhibitors of gamma-aminobutyric acid uptake.
Topics: 4-Aminobutyrate Transaminase; Administration, Oral; Alkylation; Amino Acids; Animals; Brain; Carboxylic Acids; gamma-Aminobutyric Acid; Glutamate Decarboxylase; In Vitro Techniques; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Neurotransmitter; Stereoisomerism; Synaptosomes | 1985 |
Focused pseudostatic hydrazone libraries screened by mass spectrometry binding assay: optimizing affinities toward γ-aminobutyric acid transporter 1.
Topics: GABA Plasma Membrane Transport Proteins; Hydrazones; Mass Spectrometry | 2013 |
Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors γ-aminobutyric acid transporter 1.
Topics: Binding Sites; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; HEK293 Cells; Humans; Mass Spectrometry; Molecular Structure; N-Acetylglucosaminyltransferases; Oximes; Small Molecule Libraries; Structure-Activity Relationship | 2019 |
Calcium dependent release of acetylcholine and gamma-aminobutyric acid from the rabbit retina.
Topics: Acetylcholine; Animals; Anticonvulsants; Bicuculline; Calcium; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Magnesium; Nipecotic Acids; Photic Stimulation; Physostigmine; Potassium; Rabbits; Retina | 1992 |
Changes in gamma-aminobutyric acid release induced by topical administration of drugs affecting its metabolism and receptors: studies in freely moving guinea pigs with epidural cups.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Baclofen; beta-Alanine; Calcium; Cerebral Cortex; Epidural Space; Ethanolamines; Feedback; Female; gamma-Aminobutyric Acid; Guinea Pigs; Kinetics; Male; Nipecotic Acids; Norepinephrine; Receptors, GABA-A; Sodium; Tetrodotoxin | 1992 |
GABAergic influences on somatostatin secretion from hypothalamic neurons cultured in defined medium.
Topics: Animals; Baclofen; Bicuculline; Cells, Cultured; Culture Media; GABA Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Muscimol; Neurons; Nipecotic Acids; Rats; Receptors, GABA-A; Somatostatin | 1992 |
On the activity of gamma-aminobutyric acid and glutamate transporters in chick embryonic neurons and rat synaptosomes.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport; Carrier Proteins; Cells, Cultured; Chick Embryo; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glycoproteins; Membrane Proteins; Membrane Transport Proteins; Neurons; Nipecotic Acids; Organic Anion Transporters; Rats; Rats, Inbred Strains; Synaptosomes | 1992 |
Weak effects of local and systemic administration of the GABA uptake inhibitor, SK&F 89976, on extracellular GABA in the rat striatum.
Topics: Animals; Anticonvulsants; Brain Chemistry; Chromatography, High Pressure Liquid; Corpus Striatum; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Male; Nipecotic Acids; Perfusion; Potassium; Rats; Rats, Inbred Strains | 1992 |
Co-release of acetylcholine and GABA by the starburst amacrine cells.
Topics: Acetylcholine; Animals; Autoradiography; Drug Carriers; GABA Antagonists; gamma-Aminobutyric Acid; Nipecotic Acids; Proline; Retina | 1992 |
Inhibition of transporter mediated gamma-aminobutyric acid (GABA) release by SKF 89976-A, a GABA uptake inhibitor, studied in a primary neuronal culture from chicken.
Topics: Animals; Aspartic Acid; Cells, Cultured; Chick Embryo; gamma-Aminobutyric Acid; Neurons; Nipecotic Acids; Potassium; Regression Analysis | 1992 |
Biochemical and behavioral studies following subchronic administration of GABA uptake inhibitors in mice.
Topics: Animals; Anticonvulsants; Catalepsy; Epilepsy, Tonic-Clonic; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Molecular Structure; Nicotinic Acids; Nipecotic Acids; Pentylenetetrazole; Receptors, Dopamine; Receptors, GABA-A; Time Factors | 1991 |
gamma-Aminobutyric acid (GABA) stimulates somatostatin release following activation of a GABA uptake carrier located on somatostatin nerve endings of rat cerebral cortex.
Topics: Amino Acids; Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Culture Media; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Nerve Endings; Nipecotic Acids; Picrotoxin; Rats; Rats, Inbred Strains; Somatostatin; Synaptosomes | 1991 |
On the inhibition of GABA release from a preparation of rat brain nerve-endings by SKF 89976-A, a GABA uptake inhibitor.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Calcium Chloride; Female; GABA Antagonists; gamma-Aminobutyric Acid; Nerve Endings; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Potassium Chloride; Rats; Rats, Inbred Strains | 1991 |
Stimulation of gamma-[3H]aminobutyric acid release from cultured mouse cerebral cortex neurons by sulphur-containing excitatory amino acid transmitter candidates: receptor activation mediates two distinct mechanisms of release.
Topics: Amino Acids; Animals; Calcium; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Mice; Neurons; Neurotransmitter Agents; Nipecotic Acids; Sodium; Sulfur; Tritium | 1991 |
gamma-Aminobutyric acidB receptors mediate inhibition of somatostatin release from cerebrocortex nerve terminals.
Topics: Animals; Baclofen; Cerebral Cortex; gamma-Aminobutyric Acid; Kinetics; Male; Nerve Endings; Nipecotic Acids; Potassium; Rats; Rats, Inbred Strains; Receptors, GABA-A; Somatostatin; Synaptosomes | 1991 |
Development of changes in endogenous GABA release during kindling epileptogenesis in rat hippocampus.
Topics: Animals; Anticonvulsants; Calcium; Electric Stimulation; Epilepsy; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kindling, Neurologic; Male; Nipecotic Acids; Potassium; Pyramidal Tracts; Rats; Rats, Inbred Strains; Reference Values | 1991 |
Calcium-independent gamma-aminobutyric acid release from growth cones: role of gamma-aminobutyric acid transport.
Topics: Animals; Biological Transport; Calcium; Carrier Proteins; Cell Membrane; Diencephalon; Female; gamma-Aminobutyric Acid; Male; Neurons; Nipecotic Acids; Potassium; Proline; Rats; Rats, Inbred Strains; Synaptosomes; Telencephalon | 1991 |
Cholinergic nerve terminals of human cerebral cortex possess a GABA transporter whose activation induces release of acetylcholine.
Topics: Acetylcholine; Anticonvulsants; Baclofen; Bicuculline; Biotransformation; Carrier Proteins; Cerebral Cortex; Choline; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Male; Membrane Proteins; Membrane Transport Proteins; Middle Aged; Muscimol; Nerve Endings; Nerve Tissue Proteins; Nipecotic Acids; Organic Anion Transporters; Parasympathetic Nervous System; Proline; Synaptosomes | 1991 |
GABA terminal autoreceptors in the pars compacta and in the pars reticulata of the rat substantia nigra are GABAB.
Topics: Animals; Anticonvulsants; Baclofen; gamma-Aminobutyric Acid; Male; Muscimol; Nipecotic Acids; Potassium; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra; Synaptosomes; Tritium | 1990 |
GABA uptake inhibitors containing mono- and diarylmethoxyalkyl N-substituents.
Topics: Anticonvulsants; gamma-Aminobutyric Acid; Neurotransmitter Uptake Inhibitors; Nicotinic Acids; Nipecotic Acids; Structure-Activity Relationship; Synaptosomes | 1989 |
Release-regulating autoreceptors of the GABAB-type in human cerebral cortex.
Topics: Aged; Aminooxyacetic Acid; Anticonvulsants; Baclofen; Cerebral Cortex; Female; GABA Antagonists; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Male; Middle Aged; Muscimol; Nipecotic Acids; Receptors, GABA-A; Synaptosomes | 1989 |
Presynaptic mechanisms underlying the gamma-aminobutyric acid-evoked receptor-independent release of [3H]norepinephrine in rat hippocampus.
Topics: Animals; Biomechanical Phenomena; gamma-Aminobutyric Acid; Hippocampus; Male; Nipecotic Acids; Norepinephrine; Proline; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Sodium; Synapses; Tetrodotoxin; Tritium | 1989 |
Release of endogenous GABA from the substantia nigra is not controlled by GABA autoreceptors.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Cerebral Cortex; Electric Stimulation; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Muscimol; Nipecotic Acids; Potassium; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra; Tetrodotoxin | 1989 |
Studies on [3H]GABA and endogenous GABA release in rat cerebral cortex suggest the presence of autoreceptors of the GABAB type.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Cerebral Cortex; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Median Eminence; Nipecotic Acids; Picrotoxin; Potassium; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptosomes | 1987 |
Prophylaxis of amygdala kindling-induced epileptogenesis: comparison of a GABA uptake inhibitor and diazepam.
Topics: Amygdala; Animals; Diazepam; Electric Stimulation; Female; gamma-Aminobutyric Acid; Kindling, Neurologic; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Rats; Rats, Inbred Strains | 1987 |
Prevention of amygdala kindling with an inhibitor of gamma-aminobutyric acid uptake.
Topics: Action Potentials; Amygdala; Animals; Anticonvulsants; Depression, Chemical; Female; gamma-Aminobutyric Acid; Kindling, Neurologic; Nipecotic Acids; Rats; Rats, Inbred Strains; Synaptic Transmission | 1986 |
GABA enhances acetylcholine release from hippocampal nerve endings through a mechanism blocked by a GABA uptake inhibitor.
Topics: Acetylcholine; Animals; Bicuculline; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Male; Nerve Endings; Nipecotic Acids; Rats; Receptors, GABA-A; Synaptosomes | 1986 |
Carriers for GABA and noradrenaline uptake coexist on the same nerve terminal in rat hippocampus.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Nerve Endings; Nipecotic Acids; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptosomes | 1987 |
Kinetic characterization of inhibition of gamma-aminobutyric acid uptake into cultured neurons and astrocytes by 4,4-diphenyl-3-butenyl derivatives of nipecotic acid and guvacine.
Topics: Animals; Anticonvulsants; Astrocytes; Cells, Cultured; Cerebral Cortex; Chemical Phenomena; Chemistry; GABA Antagonists; gamma-Aminobutyric Acid; Mice; Mice, Inbred Strains; Neurons; Nicotinic Acids; Nipecotic Acids; Proline | 1988 |
The measurement of the release of endogenous GABA from rat brain slices by liquid chromatography with electrochemical detection.
Topics: Amino Acids; Animals; Brain; Calcium; Chromatography, High Pressure Liquid; Electric Stimulation; Electrochemistry; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Nipecotic Acids; Perfusion; Rats; Rats, Inbred Strains | 1988 |
Coexistence of carriers for dopamine and GABA uptake on a same nerve terminal in the rat brain.
Topics: Aminobutyrates; Animals; Anticonvulsants; Brain Chemistry; Dopamine; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Nerve Endings; Nicotinic Acids; Nipecotic Acids; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Synaptosomes | 1987 |
Presence of a gamma-aminobutyric acid (GABA) uptake system on cholinergic terminals of rat hippocampus: evidence for neuronal coexistence of acetylcholine and GABA?
Topics: Acetylcholine; Animals; Choline; Cholinergic Fibers; gamma-Aminobutyric Acid; Hemicholinium 3; Hippocampus; Male; Neurons; Nicotinic Acids; Nipecotic Acids; Rats; Rats, Inbred Strains | 1987 |
Anticonvulsant action in the epileptic gerbil of novel inhibitors of GABA uptake.
Topics: Animals; Anticonvulsants; Depression, Chemical; Epilepsy; Female; gamma-Aminobutyric Acid; Gerbillinae; Male; Nicotinic Acids; Nipecotic Acids | 1985 |
Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and diazepam in amygdaloid kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Kindling, Neurologic; Nicotinic Acids; Nipecotic Acids; Rats; Rats, Inbred Strains; Seizures | 1985 |
GABA uptake inhibitors produce a greater antinociceptive response in the mouse tail-immersion assay than other types of GABAergic drugs.
Topics: Analgesics; Animals; Biological Transport; Brain; Corpus Striatum; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Nicotinic Acids; Nipecotic Acids; Oxotremorine; Pain; Tail | 1985 |
Actions of nipecotic acid and SKF89976A on GABA transporter in cone-driven horizontal cells dissociated from the catfish retina.
Topics: Animals; Anticonvulsants; Carrier Proteins; Catfishes; Dose-Response Relationship, Drug; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Membrane Proteins; Membrane Transport Proteins; Nipecotic Acids; Organic Anion Transporters; Patch-Clamp Techniques; Proline; Retina | 1995 |
Local and diffuse synaptic actions of GABA in the hippocampus.
Topics: Animals; Electric Stimulation; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; GTP-Binding Proteins; Guinea Pigs; Hippocampus; Ion Channels; Kinetics; Nipecotic Acids; Organophosphorus Compounds; Receptors, GABA-A; Synapses; Synaptic Transmission; Temperature | 1993 |
Steady states, charge movements, and rates for a cloned GABA transporter expressed in Xenopus oocytes.
Topics: Animals; Carrier Proteins; Cell Membrane; Chlorides; Cloning, Molecular; Electric Conductivity; Electrophysiology; Female; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Expression; Kinetics; Membrane Proteins; Membrane Transport Proteins; Nipecotic Acids; Oocytes; Organic Anion Transporters; RNA; RNA, Complementary; Sodium; Transfection; Xenopus | 1993 |
Inhibition of SKF 89976-A of the gamma-aminobutyric acid release from primary neuronal chick cultures.
Topics: Analysis of Variance; Animals; Anticonvulsants; Calcium; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Kinetics; Neurons; Nipecotic Acids; Potassium; Telencephalon | 1994 |
Depolarization by K+ and glutamate activates different neurotransmitter release mechanisms in GABAergic neurons: vesicular versus non-vesicular release of GABA.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Calcium; Cells, Cultured; Cobalt; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Mice; Neuromuscular Depolarizing Agents; Neurons; Neurotransmitter Agents; Nipecotic Acids; Nocodazole; Potassium; Pregnancy; Quinoxalines; Receptors, GABA-A; Synaptic Vesicles; Verapamil | 1993 |
Autoreceptor-mediated regulation of GABA release: role of uptake inhibition and effects of novel GABAB antagonists.
Topics: Animals; Bicuculline; Brain; Electric Stimulation; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Muscimol; Nipecotic Acids; Organophosphorus Compounds; Rats; Receptors, GABA-A | 1993 |
Channel behavior in a gamma-aminobutyrate transporter.
Topics: Biological Transport; Carrier Proteins; Cations; Cells, Cultured; Chlorides; Electric Conductivity; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gluconates; Ion Channel Gating; Ion Channels; Membrane Proteins; Membrane Transport Proteins; Nipecotic Acids; Organic Anion Transporters; Patch-Clamp Techniques; Recombinant Proteins; Sodium; Transfection | 1996 |
The vigilance promoting drug modafinil increases dopamine release in the rat nucleus accumbens via the involvement of a local GABAergic mechanism.
Topics: Analysis of Variance; Animals; Baclofen; Benzhydryl Compounds; Central Nervous System Stimulants; Dopamine; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Male; Modafinil; Muscimol; Nipecotic Acids; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1996 |
Effects of uptake carrier blockers SK & F 89976-A and L-trans-PDC on in vivo release of amino acids in rat hippocampus.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Dicarboxylic Acids; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Microdialysis; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Potassium; Pyrrolidines; Rats; Rats, Wistar; Taurine | 1996 |
Attenuation of excitotoxic cell swelling and GABA release by the GABA transport inhibitor SKF 89976A.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biological Transport; Chick Embryo; Chromatography, High Pressure Liquid; GABA Agents; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Kinetics; Neurotoxins; Nipecotic Acids; Retina; Sodium | 1996 |
Stimulation of [3H] GABA and beta-[3H] alanine release from rat brain slices by cis-4-aminocrotonic acid.
Topics: Alanine; Animals; Aspartic Acid; Biological Transport; Biomarkers; Carrier Proteins; Cerebellum; Cerebral Cortex; Crotonates; Dose-Response Relationship, Drug; GABA Agents; gamma-Aminobutyric Acid; Glutamine; Male; Nipecotic Acids; Organ Culture Techniques; Potassium Chloride; Rats; Rats, Sprague-Dawley; Retina; Spinal Cord; Taurine; Tritium | 1997 |
Monitoring amino acid neurotransmitter release in the brain by in vivo microdialysis.
Topics: Animals; Biosensing Techniques; Brain; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Microdialysis; Neurotransmitter Agents; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Pyrrolidines; Rats | 1997 |
Inhibitory cholinergic control of endogenous GABA release from electrically stimulated cortical slices and K(+)-depolarized synaptosomes.
Topics: Acetylcholine; Animals; Baclofen; Calcium; Cerebral Cortex; Culture Media; Electric Stimulation; Enzyme Inhibitors; Ethanolamines; Female; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Nipecotic Acids; Potassium; Synaptosomes; Tetrodotoxin | 1997 |
Activity at the GABA transporter contributes to acute cellular swelling produced by metabolic impairment in retina.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Carrier Proteins; Chick Embryo; Culture Techniques; GABA Agonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glycolysis; Iodoacetates; Ischemia; Isoxazoles; Membrane Proteins; Membrane Transport Proteins; Muscimol; Nipecotic Acids; Organic Anion Transporters; Oximes; Proline; Retina | 1997 |
Antiepileptic effects of tiagabine, a selective GABA uptake inhibitor, in the rat kindling model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Picrotoxin; Rats; Rats, Sprague-Dawley; Tiagabine; Valproic Acid | 1997 |
Carrier-mediated GABA release activates GABA receptors on hippocampal neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Carrier Proteins; Cells, Cultured; Fetus; GABA Agents; GABA Antagonists; GABA Plasma Membrane Transport Proteins; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Neurons; Nipecotic Acids; Organic Anion Transporters; Oximes; Patch-Clamp Techniques; Picrotoxin; Potassium; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sodium; Tetrodotoxin | 1998 |
Passive water and ion transport by cotransporters.
Topics: Animals; Carrier Proteins; GABA Agents; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glucose; Humans; Ion Transport; Kinetics; Membrane Glycoproteins; Membrane Proteins; Membrane Transport Proteins; Monosaccharide Transport Proteins; Nipecotic Acids; Oocytes; Organic Anion Transporters; Permeability; Phlorhizin; Rabbits; Sodium; Sodium-Glucose Transporter 1; Water; Xenopus laevis | 1999 |
GABA induces norepinephrine exocytosis from hippocampal noradrenergic axon terminals by a dual mechanism involving different voltage-sensitive calcium channels.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Exocytosis; GABA Agents; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hippocampus; Male; Membrane Potentials; Nifedipine; Nipecotic Acids; Norepinephrine; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic | 1999 |
Influence of gamma-aminobutyric acid on retinal cells excitotoxicity upon glucose deprivation.
Topics: Animals; Bicuculline; Cells, Cultured; Chick Embryo; Coloring Agents; Dose-Response Relationship, Drug; GABA Agents; GABA Antagonists; gamma-Aminobutyric Acid; Glucose; Neurons; Nipecotic Acids; Retina; Tetrazolium Salts; Thiazoles | 1999 |
[3H] gamma-aminobutyric acid transport in rat substantia nigra pars reticulata synaptosomes: pharmacological characterization and phorbol ester-induced inhibition.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Basal Ganglia; beta-Alanine; Biological Transport; Carcinogens; Colforsin; Enzyme Inhibitors; GABA Agents; gamma-Aminobutyric Acid; Nipecotic Acids; Proline; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Substantia Nigra; Synaptosomes; Tetradecanoylphorbol Acetate; Tritium | 1999 |
Effects of GABA-transporter (GAT) inhibitors on rat behaviour in open-field and elevated plus-maze.
Topics: Animals; Anticonvulsants; Anxiety; Behavior, Animal; Carrier Proteins; Dose-Response Relationship, Drug; Environment; Exploratory Behavior; GABA Agents; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Male; Membrane Proteins; Membrane Transport Proteins; Motor Activity; Nipecotic Acids; Organic Anion Transporters; Rats; Tiagabine | 1999 |
GABAb receptors regulate chick retinal calcium waves.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Carrier Proteins; Chick Embryo; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Fluorescent Dyes; GABA Agents; GABA Agonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Proteins; Membrane Transport Proteins; Nipecotic Acids; Organic Anion Transporters; Organic Chemicals; Patch-Clamp Techniques; Receptors, GABA-A; Receptors, GABA-B; Retina; Retinal Ganglion Cells; Signal Transduction | 2001 |
Attenuation of malonate toxicity in primary mesencephalic cultures using the GABA transport blocker, NO-711.
Topics: Animals; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Malonates; Mesencephalon; Muscimol; Neurons; Nipecotic Acids; Oximes; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2001 |
GABA transaminase inhibition induces spontaneous and enhances depolarization-evoked GABA efflux via reversal of the GABA transporter.
Topics: 4-Aminobutyrate Transaminase; Animals; Calcium; Carrier Proteins; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Membrane Proteins; Membrane Transport Proteins; Neural Inhibition; Neurons; Nipecotic Acids; Organic Anion Transporters; Patch-Clamp Techniques; Potassium; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Vigabatrin | 2001 |
Modulation of the in vivo effects of gabapentin by vigabatrin and SKF89976A.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Dentate Gyrus; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Evoked Potentials; Gabapentin; gamma-Aminobutyric Acid; Male; Neural Inhibition; Nipecotic Acids; Rats; Rats, Sprague-Dawley; Reaction Time; Vigabatrin | 2002 |
Vigabatrin induces tonic inhibition via GABA transporter reversal without increasing vesicular GABA release.
Topics: Animals; Anticonvulsants; Carrier Proteins; Cells, Cultured; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Hippocampus; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Neural Inhibition; Neurons; Nipecotic Acids; Organic Anion Transporters; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, GABA; Sodium; Synaptic Vesicles; Tetanus Toxin; Vigabatrin | 2003 |
GABA uptake into astrocytes is not associated with significant metabolic cost: implications for brain imaging of inhibitory transmission.
Topics: Animals; Astrocytes; Biological Transport, Active; Brain; Cells, Cultured; Deoxyglucose; gamma-Aminobutyric Acid; Glutamic Acid; Intracellular Fluid; Lactic Acid; Magnesium; Mice; Nipecotic Acids; Pyridines; Sodium; Sodium-Potassium-Exchanging ATPase; Synaptic Transmission | 2003 |
Brain-derived neurotrophic factor facilitates glutamate and inhibits GABA release from hippocampal synaptosomes through different mechanisms.
Topics: Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Cadmium Chloride; Calcium; Calcium Channel Blockers; Carbazoles; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; GABA Agents; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Indole Alkaloids; Male; Neurons; Nipecotic Acids; Potassium; Rats; Rats, Wistar; Synaptosomes; Tritium | 2004 |
Relations between substrate affinities and charge equilibration rates in the rat GABA cotransporter GAT1.
Topics: Animals; DNA, Complementary; Electrophysiology; GABA Agents; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Membrane Potentials; Membrane Transport Proteins; Nipecotic Acids; Patch-Clamp Techniques; Point Mutation; Rats; Recombinant Proteins; RNA, Messenger; Sodium; Solutions; Valproic Acid; Xenopus laevis | 2005 |
GABAergic modulation of the activity of globus pallidus neurons in primates: in vivo analysis of the functions of GABA receptors and GABA transporters.
Topics: Action Potentials; Animals; Anisoles; Baclofen; Brain Mapping; Enzyme Inhibitors; GABA Agonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Globus Pallidus; Immunohistochemistry; Macaca mulatta; Membrane Transport Modulators; Membrane Transport Proteins; Microdialysis; Microscopy, Immunoelectron; Muscimol; Neurons; Nipecotic Acids; Phosphinic Acids; Propanolamines; Pyridazines; Receptors, GABA | 2005 |
Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Drug Interactions; Epilepsy; GABA Agents; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Imidazoles; Immunohistochemistry; In Vitro Techniques; Male; Membrane Potentials; Neural Inhibition; Neuronal Plasticity; Neurons; Nipecotic Acids; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tetrodotoxin | 2005 |
The Caenorhabditis elegans snf-11 gene encodes a sodium-dependent GABA transporter required for clearance of synaptic GABA.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; GABA Agents; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Genes, Helminth; Mutation; Nipecotic Acids; Phenotype; Phylogeny; Sodium; Synapses; Synaptic Transmission | 2006 |
Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels.
Topics: Animals; Animals, Newborn; Anticonvulsants; Chloride Channels; Dioxolanes; Disease Models, Animal; Drug Interactions; Epilepsy; Excitatory Postsynaptic Potentials; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Neural Inhibition; Nipecotic Acids; Oximes; Patch-Clamp Techniques; Pentobarbital; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Transmission | 2006 |
Electrically evoked GABA release in rat hippocampus CA1 region and its changes during kindling epileptogenesis.
Topics: Animals; Anticonvulsants; Baclofen; Electric Stimulation; Epilepsy; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kindling, Neurologic; Male; Nipecotic Acids; Rats; Rats, Wistar | 2007 |
On the presence of 3H-GABA uptake mechanism in bovine spermatozoa.
Topics: Animals; Cattle; gamma-Aminobutyric Acid; Glutamic Acid; Male; Nipecotic Acids; Spermatozoa; Tritium | 2008 |
Gamma-vinyl GABA increases nonvesicular release of GABA and glutamate in the nucleus accumbens in rats via action on anion channels and GABA transporters.
Topics: Animals; Drug Interactions; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Ion Channels; Male; Microdialysis; Microinjections; Nipecotic Acids; Nitrobenzoates; Nucleus Accumbens; Rats; Rats, Long-Evans; Synaptic Transmission; Synaptic Vesicles; Tetrodotoxin; Vigabatrin | 2010 |
In vitro activation of GAT1 transporters expressed in spinal cord gliosomes stimulates glutamate release that is abnormally elevated in the SOD1/G93A(+) mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Calcium; Chelating Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Egtazic Acid; GABA Agents; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Expression Regulation; Gliosis; Glutamic Acid; Humans; L-Lactate Dehydrogenase; Mice; Mice, Transgenic; Nerve Tissue Proteins; Nipecotic Acids; Spinal Cord; Superoxide Dismutase | 2010 |
Passive water permeability of some wild type and mutagenized amino acid cotransporters of the SLC6/NSS family expressed in Xenopus laevis oocytes.
Topics: Amino Acid Transport Systems, Neutral; Amino Acids; Animals; Carrier Proteins; Cell Membrane; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Insect Proteins; Membrane Proteins; Mutagenesis, Site-Directed; Mutant Proteins; Nipecotic Acids; Oocytes; Osmotic Pressure; Permeability; Water; Xenopus laevis | 2010 |
A possible role of the non-GAT1 GABA transporters in transfer of GABA from GABAergic to glutamatergic neurons in mouse cerebellar neuronal cultures.
Topics: Animals; Betaine; Cells, Cultured; Cerebellum; GABA Agents; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Lipotropic Agents; Mice; Neurons; Nipecotic Acids; Tiagabine; Vesicular Glutamate Transport Protein 1 | 2010 |
Basal GABA regulates GABA(B)R conformation and release probability at single hippocampal synapses.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Animals, Newborn; Baclofen; CA1 Region, Hippocampal; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Egtazic Acid; Electric Stimulation; Excitatory Postsynaptic Potentials; GABA Agents; gamma-Aminobutyric Acid; In Vitro Techniques; Microscopy, Confocal; Neurons; Nipecotic Acids; Organophosphorus Compounds; Potassium Chloride; Presynaptic Terminals; Probability; Protein Conformation; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, GABA-B; Synapses; Tetrodotoxin | 2010 |
Modulation of GABA transport by adenosine A1R-A2AR heteromers, which are coupled to both Gs- and G(i/o)-proteins.
Topics: Analysis of Variance; Animals; Animals, Newborn; Astrocytes; Bacterial Proteins; Biotinylation; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; GABA Agents; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Luminescent Proteins; Models, Biological; Nipecotic Acids; Phenylisopropyladenosine; Protein Binding; Purinergic Agents; Rats; Rats, Wistar; Receptors, Adenosine A2; Recombinant Proteins; Time Factors; Transfection; Tritium | 2011 |
The effects of volatile anesthetics on the extracellular accumulation of [(3)H]GABA in rat brain cortical slices.
Topics: Anesthetics; Animals; beta-Alanine; Calcium; Cerebral Cortex; Cold Temperature; Extracellular Space; gamma-Aminobutyric Acid; Halothane; Methyl Ethers; Nipecotic Acids; Ouabain; Rats; Sevoflurane; Tetrodotoxin; Tritium; Volatilization | 2014 |
A new function for glycine GlyT2 transporters: Stimulation of γ-aminobutyric acid release from cerebellar nerve terminals through GAT1 transporter reversal and Ca(2+)-dependent anion channels.
Topics: Analysis of Variance; Animals; Calcium; Calcium Channel Blockers; Cerebellum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Agents; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Glycine Plasma Membrane Transport Proteins; Kynurenic Acid; Male; Mice; Nerve Tissue Proteins; Nipecotic Acids; Synaptosomes; Tritium | 2014 |