n-(4-(n-((2,4-diaminofuro(2,3-d)pyrimidin-5-yl)methyl)amino)benzoyl)glutamic acid has been researched along with aminopterin in 3 studies
| Studies (n-(4-(n-((2,4-diaminofuro(2,3-d)pyrimidin-5-yl)methyl)amino)benzoyl)glutamic acid) | Trials (n-(4-(n-((2,4-diaminofuro(2,3-d)pyrimidin-5-yl)methyl)amino)benzoyl)glutamic acid) | Recent Studies (post-2010) (n-(4-(n-((2,4-diaminofuro(2,3-d)pyrimidin-5-yl)methyl)amino)benzoyl)glutamic acid) | Studies (aminopterin) | Trials (aminopterin) | Recent Studies (post-2010) (aminopterin) |
|---|---|---|---|---|---|
| 5 | 0 | 0 | 1,389 | 73 | 109 |
| Protein | Taxonomy | n-(4-(n-((2,4-diaminofuro(2,3-d)pyrimidin-5-yl)methyl)amino)benzoyl)glutamic acid (IC50) | aminopterin (IC50) |
|---|---|---|---|
| Dihydrofolate reductase | Homo sapiens (human) | 0.0201 | |
| Dihydrofolate reductase | Mus musculus (house mouse) | 0.0253 | |
| Dihydrofolate reductase | Lacticaseibacillus casei | 0.005 | |
| Dihydrofolate reductase | Escherichia coli K-12 | 0.011 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Devraj, R; Gangjee, A; Kisliuk, RL; McGuire, JJ | 1 |
| Gangjee, A; Kisliuk, RL; McGuire, JJ; Zeng, Y | 1 |
| Cody, V; Galitsky, N; Gangjee, A; Kisliuk, RL; McGuire, JJ; Queener, SF; Yu, J | 1 |
3 other study(ies) available for n-(4-(n-((2,4-diaminofuro(2,3-d)pyrimidin-5-yl)methyl)amino)benzoyl)glutamic acid and aminopterin
| Article | Year |
|---|---|
Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
Topics: Antineoplastic Agents; Cell Division; Folic Acid; Folic Acid Antagonists; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Lacticaseibacillus casei; Leucovorin; Methotrexate; Molecular Structure; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Recombinant Proteins; Structure-Activity Relationship; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1995 |
Effect of C9-methyl substitution and C8-C9 conformational restriction on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Escherichia coli; Folic Acid; Folic Acid Antagonists; Humans; Lacticaseibacillus casei; Rats; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Toxoplasma; Tumor Cells, Cultured | 2000 |
Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent.
Topics: Animals; Antineoplastic Agents; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Escherichia coli; Folic Acid Antagonists; Glutamic Acid; Humans; Lacticaseibacillus casei; Models, Molecular; Pneumocystis; Pyrimidines; Rats; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Toxoplasma; Tumor Cells, Cultured | 2000 |