Compounds > n-(4-(2-chloroethylmethylamino)-2-butynyl)-2-pyrrolidone
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n-(4-(2-chloroethylmethylamino)-2-butynyl)-2-pyrrolidone and oxotremorine

n-(4-(2-chloroethylmethylamino)-2-butynyl)-2-pyrrolidone has been researched along with oxotremorine in 9 studies

Compound Research Comparison

Studies
(n-(4-(2-chloroethylmethylamino)-2-butynyl)-2-pyrrolidone)		Trials
(n-(4-(2-chloroethylmethylamino)-2-butynyl)-2-pyrrolidone)		Recent Studies (post-2010)
(n-(4-(2-chloroethylmethylamino)-2-butynyl)-2-pyrrolidone)		Studies
(oxotremorine)		Trials
(oxotremorine)		Recent Studies (post-2010) (oxotremorine)
15001,930699

Protein Interaction Comparison

ProteinTaxonomyn-(4-(2-chloroethylmethylamino)-2-butynyl)-2-pyrrolidone (IC50)oxotremorine (IC50)
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.4
Muscarinic acetylcholine receptor M4Homo sapiens (human)5
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)2.321
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)2.7261
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)2.7261
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)2.7261
Muscarinic acetylcholine receptor M5Homo sapiens (human)8
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)2.7261
Muscarinic acetylcholine receptor M1Homo sapiens (human)4.5012

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19908 (88.89)18.7374
1990's1 (11.11)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hyslop, DK; Sethy, VH1
Booth, RA; Jenden, DJ; Russell, RW; Smith, CA; Waite, JJ1
Booth, RA; Jenden, DJ; Overstreet, DH1
Francis, JW; Sethy, VH1
Ehlert, FJ1
Jenden, DJ; Ringdahl, B1
Ehlert, FJ; Jenden, DJ1
Booth, RA; Jenden, DJ; Overstreet, DH; Rice, KM; Russell, RW1
Dahlbom, R; Ehlert, FJ; Jenden, DJ; Resul, B; Ringdahl, B1

Other Studies

9 other study(ies) available for n-(4-(2-chloroethylmethylamino)-2-butynyl)-2-pyrrolidone and oxotremorine

ArticleYear
Effect of irreversible loss of muscarinic receptors on (3H)-acetylcholine release from the hippocampus.
    Neuropharmacology, 1990, Volume: 29, Issue:2

    Topics: Acetylcholine; Animals; Hippocampus; Male; Oxotremorine; Parasympatholytics; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Muscarinic

1990
Behavioral and physiological effects associated with changes in muscarinic receptors following administration of an irreversible cholinergic agonist (BM 123).
    Psychopharmacology, 1986, Volume: 90, Issue:3

    Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Conditioning, Operant; Male; Motor Activity; Nociceptors; Oxotremorine; Parasympathomimetics; Pyrrolidinones; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic

1986
Effects of an irreversible muscarinic agonist (BM123) on avoidance and spontaneous alternation performance.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 31, Issue:2

    Topics: Animals; Atropine; Atropine Derivatives; Avoidance Learning; Behavior, Animal; Body Temperature; Dose-Response Relationship, Drug; Male; Oxotremorine; Parasympatholytics; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Muscarinic

1988
Regulation of brain acetylcholine concentration by muscarinic receptors.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:1

    Topics: Acetylcholine; Animals; Arecoline; Brain; Homeostasis; Male; Mice; Microwaves; Oxotremorine; Pyrrolidinones; Receptors, Muscarinic; Time Factors

1988
Effects of an alkylating derivative of oxotremorine (BM 123A) on heart rate, muscarinic receptors and adenylate cyclase activity in the rabbit myocardium.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:3

    Topics: Adenylyl Cyclases; Animals; Aziridines; Azirines; Guanosine Triphosphate; Heart Rate; Male; Mathematics; Myocardium; N-Methylscopolamine; Oxotremorine; Pyrrolidinones; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives

1987
Muscarinic actions of an N-methyl-N-2-bromoethylamino analog of oxotremorine (BR 401) in the mouse.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:2

    Topics: Analgesics; Animals; Atropine; Body Temperature Regulation; Male; Mice; Oxotremorine; Parasympathomimetics; Pyrrolidinones; Salivation; Structure-Activity Relationship; Tremor

1987
The binding of a 2-chloroethylamine derivative of oxotremorine (BM 123) to muscarinic receptors in the rat cerebral cortex.
    Molecular pharmacology, 1985, Volume: 28, Issue:2

    Topics: Alkylation; Animals; Atropine; Benzodiazepinones; Binding Sites; Binding, Competitive; Cerebral Cortex; Gallamine Triethiodide; Kinetics; N-Methylscopolamine; Oxotremorine; Pirenzepine; Pyrrolidinones; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Structure-Activity Relationship; Thiosulfates

1985
Unexpected synergism between an alkylating analog of oxotremorine and soman.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1985, Volume: 5, Issue:6 Pt 2

    Topics: Acetylcholinesterase; Animals; Atropine; Atropine Derivatives; Body Temperature; Brain; Carboxylesterase; Carboxylic Ester Hydrolases; Cholinesterase Inhibitors; Drug Synergism; Oxotremorine; Parasympatholytics; Pyrrolidinones; Rats; Rats, Inbred Strains; Soman

1985
The conversion of 2-chloroalkylamine analogues of oxotremorine to aziridinium ions and their interactions with muscarinic receptors in the guinea pig ileum.
    Molecular pharmacology, 1984, Volume: 26, Issue:2

    Topics: Alkylation; Animals; Aziridines; Azirines; Binding, Competitive; Carbachol; Chlorides; Guinea Pigs; Hydrolysis; Ileum; Indicators and Reagents; Kinetics; Muscle Contraction; Oxotremorine; Pyrrolidinones; Quinuclidinyl Benzilate; Rana pipiens; Receptors, Muscarinic

1984