Compounds > n-(4-(2-chloroethylmethylamino)-2-butynyl)-2-pyrrolidone
Page last updated: 2024-09-05

n-(4-(2-chloroethylmethylamino)-2-butynyl)-2-pyrrolidone and atropine

n-(4-(2-chloroethylmethylamino)-2-butynyl)-2-pyrrolidone has been researched along with atropine in 5 studies

Compound Research Comparison

Studies
(n-(4-(2-chloroethylmethylamino)-2-butynyl)-2-pyrrolidone)		Trials
(n-(4-(2-chloroethylmethylamino)-2-butynyl)-2-pyrrolidone)		Recent Studies (post-2010)
(n-(4-(2-chloroethylmethylamino)-2-butynyl)-2-pyrrolidone)		Studies
(atropine)		Trials
(atropine)		Recent Studies (post-2010) (atropine)
150026,7111,2591,697

Protein Interaction Comparison

ProteinTaxonomyn-(4-(2-chloroethylmethylamino)-2-butynyl)-2-pyrrolidone (IC50)atropine (IC50)
cystic fibrosis transmembrane conductance regulatorHomo sapiens (human)21.41
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)1.012
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.0067
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.0007
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)0.001
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)0.001
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)0.001
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)0.001
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.0009
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)0.001
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.0015
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.0021
Alpha-1D adrenergic receptorHomo sapiens (human)1.354
5-hydroxytryptamine receptor 2CHomo sapiens (human)1.012

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19905 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Booth, RA; Jenden, DJ; Overstreet, DH1
Booth, RA; Jenden, DJ; Overstreet, DH; Russell, RW1
Jenden, DJ; Ringdahl, B1
Ehlert, FJ; Jenden, DJ1
Booth, RA; Jenden, DJ; Overstreet, DH; Rice, KM; Russell, RW1

Other Studies

5 other study(ies) available for n-(4-(2-chloroethylmethylamino)-2-butynyl)-2-pyrrolidone and atropine

ArticleYear
Effects of an irreversible muscarinic agonist (BM123) on avoidance and spontaneous alternation performance.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 31, Issue:2

    Topics: Animals; Atropine; Atropine Derivatives; Avoidance Learning; Behavior, Animal; Body Temperature; Dose-Response Relationship, Drug; Male; Oxotremorine; Parasympatholytics; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Muscarinic

1988
Influence of atropine and N-methyl atropine pretreatments on behavioral and physiological effects of the irreversible muscarinic agonist, BM123.
    Pharmacology, biochemistry, and behavior, 1987, Volume: 26, Issue:3

    Topics: Animals; Atropine; Atropine Derivatives; Behavior, Animal; Body Temperature; Habituation, Psychophysiologic; Motor Activity; Pain; Parasympatholytics; Pyrrolidinones; Rats; Rats, Inbred Strains; Sensory Thresholds; Time Factors

1987
Muscarinic actions of an N-methyl-N-2-bromoethylamino analog of oxotremorine (BR 401) in the mouse.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:2

    Topics: Analgesics; Animals; Atropine; Body Temperature Regulation; Male; Mice; Oxotremorine; Parasympathomimetics; Pyrrolidinones; Salivation; Structure-Activity Relationship; Tremor

1987
The binding of a 2-chloroethylamine derivative of oxotremorine (BM 123) to muscarinic receptors in the rat cerebral cortex.
    Molecular pharmacology, 1985, Volume: 28, Issue:2

    Topics: Alkylation; Animals; Atropine; Benzodiazepinones; Binding Sites; Binding, Competitive; Cerebral Cortex; Gallamine Triethiodide; Kinetics; N-Methylscopolamine; Oxotremorine; Pirenzepine; Pyrrolidinones; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Structure-Activity Relationship; Thiosulfates

1985
Unexpected synergism between an alkylating analog of oxotremorine and soman.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1985, Volume: 5, Issue:6 Pt 2

    Topics: Acetylcholinesterase; Animals; Atropine; Atropine Derivatives; Body Temperature; Brain; Carboxylesterase; Carboxylic Ester Hydrolases; Cholinesterase Inhibitors; Drug Synergism; Oxotremorine; Parasympatholytics; Pyrrolidinones; Rats; Rats, Inbred Strains; Soman

1985