n-(3-((2-hydroxynaphthalen-1-ylmethylene)amino)phenyl)-2-phenylpropionamide has been researched along with sirtinol* in 1 studies
1 other study(ies) available for n-(3-((2-hydroxynaphthalen-1-ylmethylene)amino)phenyl)-2-phenylpropionamide and sirtinol
| Article | Year |
|---|---|
Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues.
In oculopharyngeal muscular dystrophy (OPMD), a disease caused by polyalanine expansion in the nuclear protein PABPN1, the genetic inhibition of sirtuins and treatment with sirtuin inhibitors protect from mutant PABPN1 toxicity in transgenic nematodes. Here, we tested the SIRT1/2 inhibitors 1-12, bearing different degrees of inhibition, for protection against mutant PABPN1 toxicity in Caenorhabditis elegans. Compounds 2, 4, and 11 were the most efficient, revealing a potential therapeutic application for muscle cell protection in OPMD. Topics: Animals; Animals, Genetically Modified; Benzamides; Caenorhabditis elegans; Cell Movement; Green Fluorescent Proteins; Histone Deacetylase Inhibitors; Muscle Cells; Muscular Dystrophy, Oculopharyngeal; Naphthols; Poly(A)-Binding Protein I; Sirtuins | 2010 |