n-(2-methylbenzyl)linoleamide and simvastatin-acid

n-(2-methylbenzyl)linoleamide has been researched along with simvastatin-acid* in 1 studies

Other Studies

1 other study(ies) available for n-(2-methylbenzyl)linoleamide and simvastatin-acid

Article	Year
Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochemical pharmacology, 1993, Jul-20, Volume: 46, Issue:2 Caco-2 cells grown on membrane filters were used as a model to study the effects of NB-598, an inhibitor of squalene epoxidase, on cholesterol absorption from the intestinal epithelia. NB-598 (10 microM) inhibited the synthesis of sterol and sterol ester from [14C]acetate without affecting the synthesis of other lipids such as phospholipids (PL), free fatty acids (FFA) and triacylglycerol (TG). When labeled lipid was apically loaded as a micellar lipid solution into Caco-2 cell cultures, NB-598 reduced basolaterally secreted radioactivity in cholesterol, cholesterol ester, PL and TG. Furthermore, NB-598 suppressed the basolateral secretion of apolipoprotein (apo) B. When microsomes prepared from control Caco-2 cells were incubated with 10 microM NB-598, acyl CoA:cholesterol acyltransferase (ACAT) activity was inhibited slightly. After incubating Caco-2 cells with 10 microM NB-598, a slight reduction in cellular ACAT activity was also observed. These results suggest that suppression of the secretion of particles containing apo B and reduction of cellular ACAT activity in the intestinal epithelia are part of the mechanism of the cholesterol-lowering effect of NB-598. Topics: Anticholesteremic Agents; Apolipoprotein A-I; Apolipoproteins B; Benzylamines; Cell Line; Cell Membrane; Cholesterol; Cholesterol Esters; Enzyme Activation; Humans; Linoleic Acids; Lipids; Lovastatin; Microsomes; Oleic Acid; Oleic Acids; Oxygenases; Polyunsaturated Alkamides; Simvastatin; Squalene Monooxygenase; Sterol O-Acyltransferase; Thiophenes; Tritium; Tumor Cells, Cultured	1993

Article

Year

Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells.

Biochemical pharmacology, 1993, Jul-20, Volume: 46, Issue:2

Caco-2 cells grown on membrane filters were used as a model to study the effects of NB-598, an inhibitor of squalene epoxidase, on cholesterol absorption from the intestinal epithelia. NB-598 (10 microM) inhibited the synthesis of sterol and sterol ester from [14C]acetate without affecting the synthesis of other lipids such as phospholipids (PL), free fatty acids (FFA) and triacylglycerol (TG). When labeled lipid was apically loaded as a micellar lipid solution into Caco-2 cell cultures, NB-598 reduced basolaterally secreted radioactivity in cholesterol, cholesterol ester, PL and TG. Furthermore, NB-598 suppressed the basolateral secretion of apolipoprotein (apo) B. When microsomes prepared from control Caco-2 cells were incubated with 10 microM NB-598, acyl CoA:cholesterol acyltransferase (ACAT) activity was inhibited slightly. After incubating Caco-2 cells with 10 microM NB-598, a slight reduction in cellular ACAT activity was also observed. These results suggest that suppression of the secretion of particles containing apo B and reduction of cellular ACAT activity in the intestinal epithelia are part of the mechanism of the cholesterol-lowering effect of NB-598.

Topics: Anticholesteremic Agents; Apolipoprotein A-I; Apolipoproteins B; Benzylamines; Cell Line; Cell Membrane; Cholesterol; Cholesterol Esters; Enzyme Activation; Humans; Linoleic Acids; Lipids; Lovastatin; Microsomes; Oleic Acid; Oleic Acids; Oxygenases; Polyunsaturated Alkamides; Simvastatin; Squalene Monooxygenase; Sterol O-Acyltransferase; Thiophenes; Tritium; Tumor Cells, Cultured

1993