n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and rofecoxib

n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide has been researched along with rofecoxib in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (6.67)18.2507
2000's13 (86.67)29.6817
2010's1 (6.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barbey, S; Charlier, C; Choesmel, V; Cornet, J; Gimeno, G; Goossens, L; Hénichart, JP; Houssin, R; Michaux, C; Rouaud, C; Taverne, T; Yannic-Arnoult, S1
Bohlin, L; Huss, U; Perera, P; Ringbom, T; Vasänge, M1
Backlund, A; Bohlin, L; Gottfries, J; Larsson, J1
Basset, J; Casula, G; Cusimano, MG; Harrak, Y; Plescia, S; Pouplana, R; Pujol, MD; Raffa, D; Rosell, G1
Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Pajdo, R; Sliwowski, Z; Stachura, J1
Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Nakamura, T; Pajdo, R; Pawlik, M; Ptak, A; Schuppan, D1
Bielański, W; Bonior, J; Jachimczak, B; Jaworek, J; Konturek, PC; Konturek, SJ; Kot, M; Pawlik, WW; Sendur, R; Stachura, J; Tomaszewska, R1
Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Pajdo, R; Ptak, A; Sliwowski, Z1
Chen, C; Hsu, A; Johnson, AJ; song, X1
Cordasic, N; Goppelt-Struebe, M; Hartner, A; Hilgers, KF; Veelken, R1
LaPointe, MC; Leung, A; Mendez, M; Tao, Z; Yang, XP1
Jackson, BJ; McFadden, DW; Riggs, DR; Vona-Davis, L1
Babaev, VR; Burleigh, ME; Fazio, S; Linton, MF; Major, AS; McCaleb, JL; Morrow, JD; Oates, JA; Yancey, PG1
Beaulieu, P; De Léan, A; Guindon, J; LoVerme, J; Piomelli, D1
Cheng, Y; Ding, G; Huang, H; Sun, W; Tao, J; Zhang, Y1

Other Studies

15 other study(ies) available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and rofecoxib

ArticleYear
Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.
    Bioorganic & medicinal chemistry letters, 2002, Mar-11, Volume: 12, Issue:5

    Topics: Animals; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Granulocytes; Inhibitory Concentration 50; Isoenzymes; Lipoxygenase Inhibitors; Male; Monocytes; Osteosarcoma; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Structure-Activity Relationship; Sulfones

2002
Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.
    Journal of natural products, 2002, Volume: 65, Issue:11

    Topics: Acrolein; Alkaloids; Animals; Anthraquinones; Aspirin; Biological Assay; Catalysis; Cinnamomum zeylanicum; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Eugenol; Flavonoids; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Kinetics; Lactones; Models, Molecular; Nitrobenzenes; Oleanolic Acid; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Pyrogallol; Steroids; Sulfonamides; Sulfones; Syzygium; Terpenes; Triterpenes; Ursolic Acid

2002
Expanding the ChemGPS chemical space with natural products.
    Journal of natural products, 2005, Volume: 68, Issue:7

    Topics: Biological Products; Combinatorial Chemistry Techniques; Computer Graphics; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship

2005
Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones.
    Journal of medicinal chemistry, 2010, Sep-23, Volume: 53, Issue:18

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Screening Assays, Antitumor; Humans; Hydrophobic and Hydrophilic Interactions; Indoles; Models, Molecular; Rats; Stereoisomerism; Structure-Activity Relationship; Sulfones; Thermodynamics

2010
Role of prostaglandins generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia-reperfusion-induced gastric lesions.
    European journal of pharmacology, 1999, Nov-26, Volume: 385, Issue:1

    Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Gastric Mucosa; Gastrins; Gene Expression Regulation, Enzymologic; Indomethacin; Interleukin-1; Isoenzymes; Lactones; Meloxicam; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Regional Blood Flow; Reperfusion Injury; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stilbenes; Stomach Ulcer; Sulfonamides; Sulfones; Thiazines; Thiazoles; Time Factors

1999
Involvement of cyclooxygenase (COX)-2 products in acceleration of ulcer healing by gastrin and hepatocyte growth factor.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2000, Volume: 51, Issue:4 Pt 1

    Topics: Animals; Antibodies; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Gastric Mucosa; Gastrins; Hepatocyte Growth Factor; Indomethacin; Isoenzymes; Lactones; Male; Membrane Proteins; Nitrobenzenes; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Sulfones

2000
Involvement of cyclooxygenase-derived prostaglandin E2 and nitric oxide in the protection of rat pancreas afforded by low dose of lipopolysaccharide.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2001, Volume: 52, Issue:1

    Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ceruletide; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Indomethacin; Isoenzymes; Lactones; Lipopolysaccharides; Male; Membrane Proteins; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nitrobenzenes; Organ Size; Pancreas; Pancreatitis; Penicillamine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Resveratrol; S-Nitroso-N-Acetylpenicillamine; Stilbenes; Sulfonamides; Sulfones

2001
Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers.
    Microscopy research and technique, 2001, Jun-01, Volume: 53, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Mucosa; Gastrins; Indomethacin; Interleukin-1; Isoenzymes; Lactones; Male; Meloxicam; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Rats; Rats, Wistar; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stilbenes; Stomach Ulcer; Sulfonamides; Sulfones; Thiazines; Thiazoles; Tumor Necrosis Factor-alpha

2001
Apoptosis signaling pathways mediated by cyclooxygenase-2 inhibitors in prostate cancer cells.
    Advances in enzyme regulation, 2001, Volume: 41

    Topics: Apoptosis; Calcium; Celecoxib; Cell Cycle; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Models, Chemical; Nitrobenzenes; Phosphatidylinositol 3-Kinases; Prostaglandin-Endoperoxide Synthases; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Pyrazoles; Signal Transduction; Sulfonamides; Sulfones; Thiophenes; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2001
Role of macula densa cyclooxygenase-2 in renovascular hypertension.
    American journal of physiology. Renal physiology, 2003, Volume: 284, Issue:3

    Topics: Animals; Blood Pressure; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Hypertension, Renovascular; Immunohistochemistry; Isoenzymes; Lactones; Loop of Henle; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Renin; Sodium, Dietary; Sulfonamides; Sulfones

2003
Inhibition of cyclooxygenase-2 improves cardiac function after myocardial infarction in the mouse.
    American journal of physiology. Heart and circulatory physiology, 2004, Volume: 286, Issue:4

    Topics: Animals; Cardiomegaly; Collagen; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Echocardiography; Fibrosis; Heart; Immunohistochemistry; Isoenzymes; Lactones; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; Natriuretic Peptide, Brain; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Sulfones; Transforming Growth Factor beta

2004
Antiproliferative and apoptotic effects of rofecoxib on esophageal cancer in vitro(1).
    The Journal of surgical research, 2004, Jun-15, Volume: 119, Issue:2

    Topics: Adenocarcinoma; Apoptosis; Cell Division; Cell Line, Tumor; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Esophageal Neoplasms; Humans; In Vitro Techniques; Isoenzymes; Lactones; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Sulfones

2004
Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice.
    Journal of molecular and cellular cardiology, 2005, Volume: 39, Issue:3

    Topics: Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Cells, Cultured; Chemokine CCL2; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Immunohistochemistry; Indomethacin; Lactones; Lipopolysaccharides; Liver Transplantation; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Sulfones; Transplantation, Heterologous; Tumor Necrosis Factor-alpha

2005
Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides?
    European journal of pharmacology, 2006, Nov-21, Volume: 550, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Capsaicin; Chromatography, High Pressure Liquid; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Edema; Endocannabinoids; Formaldehyde; Ibuprofen; Lactones; Male; Mass Spectrometry; Nitrobenzenes; Pain Measurement; Peripheral Nervous System; Polyunsaturated Alkamides; Rats; Rats, Wistar; Sulfonamides; Sulfones; TRPV Cation Channels

2006
Effects of celecoxib on voltage-gated calcium channel currents in rat pheochromocytoma (PC12) cells.
    Pharmacological research, 2007, Volume: 56, Issue:3

    Topics: Adrenal Gland Neoplasms; Animals; Antineoplastic Agents; Barium; Calcium Channel Blockers; Calcium Channels, L-Type; Celecoxib; Cell Proliferation; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Isoquinolines; Lactones; Membrane Potentials; Nifedipine; Nitrobenzenes; omega-Agatoxin IVA; omega-Conotoxin GVIA; PC12 Cells; Pheochromocytoma; Protein Kinase Inhibitors; Pyrazoles; Rats; Spider Venoms; Sulfonamides; Sulfones

2007