n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide has been researched along with indomethacin in 267 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 76 (28.46) | 18.2507 |
| 2000's | 161 (60.30) | 29.6817 |
| 2010's | 29 (10.86) | 24.3611 |
| 2020's | 1 (0.37) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, GD; Burton, EG; Cogburn, JN; Collins, JT; Garland, DJ; Gregory, SA; Huang, HC; Isakson, PC; Koboldt, CM; Li, JJ | 1 |
| Anderson, GD; Collins, JT; Gregory, SA; Koboldt, CM; Li, JJ; Norton, MB; Perkins, WE; Reinhard, EJ; Reitz, DB; Seibert, K | 1 |
| Bohlin, L; Danielson, H; Noreen, Y; Perera, P; Ringbom, T | 1 |
| Bohlin, L; Noreen, Y; Perera, P; Ringbom, T; Segura, L | 1 |
| Bornemeier, DA; Chan, K; Connor, DT; Doubleday, R; Dyer, RD; Gilbertsen, RB; Guglietta, A; Roth, BD; Schrier, DJ; Sercel, AD; Song, Y; Sorenson, RJ; Unangst, PC | 1 |
| Beylin, VG; Bornemeier, DA; Chan, K; Connor, DT; Doubleday, R; Dyer, RD; Gilbertsen, RB; Guglietta, A; Roth, BD; Schrier, DJ; Sercel, AD; Song, Y; Sorenson, RJ; Unangst, PC | 1 |
| Alcaraz, MJ; González, LM; Peinador, C; Quintela, JM; Riguera, R; Rioja, I; Terencio, MC; Ubeda, A | 1 |
| Arimura, A; Hori, Y; Inagaki, M; Jyoyama, H; Kakudo, S; Kato, M; Kawai, S; Kobayashi, M; Koizumi, K; Matsumoto, S; Ohno, K; Ono, T; Suzuki, R; Tsuri, T; Yamada, K; Yasui, K | 1 |
| Bohlin, L; Huss, U; Perera, P; Ringbom, T; Vasänge, M | 1 |
| Backlund, A; Bohlin, L; Gottfries, J; Larsson, J | 1 |
| Elagib, KE; Goldfarb, AN; Munson, KM; Peterson, RT; Sweetser, DA; Yeh, JR | 1 |
| Adams, M; Bauer, R; Bodensieck, A; Haslinger, E; Hüfner, A; Kunert, O; Oluwemimo, A; Pferschy-Wenzig, EM; Prettner, E; Schühly, W | 1 |
| Balkan, A; Ozden, K; Rauk, A; Unsal-Tan, O | 1 |
| Bauer, R; Blunder, M; Fabian, WM; Hüfner, A; Kunert, O; Pferschy-Wenzig, EM; Saf, R; Schühly, W | 1 |
| Atanasov, AG; Bauer, J; Bauer, R; Baumgartner, L; Bodensieck, A; Dirsch, VM; Fakhrudin, N; Favero, GD; Heiss, EH; Ladurner, A; Loggia, RD; Ponti, C; Rollinger, JM; Schwaiger, S; Sosa, S; Stuppner, H; Tubaro, A; Werz, O; Widowitz, U | 1 |
| Balkan, A; Ozadali, K; Piskin, K; Unsal-Tan, O | 1 |
| Abdel-Aziz, M; Abdel-Rahman, IM; Aly, OM; Beshr, EA; Ozadali, K; Tan, OU | 1 |
| Ahangar, N; Ahmadnejad, M; Dadashpour, S; Emami, S; Irannejad, H; Ozadali, K; Tuylu Kucukkilinc, T; Unsal Tan, O | 1 |
| Ertan, M; Kazkayasi, I; Okay, G; Ozadali-Sari, K; Sarigol, D; Somuncuoglu, EI; Tel, BC; Tozkoparan, B; Unsal-Tan, O; Uzgoren-Baran, A | 1 |
| Bauer, R; Faist, J; Kaserer, T; Ortmann, S; Otto, N; Presser, A; Saf, R; Schuster, D; Seebacher, W; Temml, V; Weis, R | 1 |
| Abonia, R; Marín-Ocampo, L; Sepúlveda-Arias, JC; Veloza, LA | 1 |
| Creely, DP; Gierse, JK; Hauser, SD; Isakson, PC; Koboldt, C; Rangwala, SH; Seibert, K | 1 |
| Ouellet, M; Percival, MD | 1 |
| Endo, T; Hayashi, Y; Ogura, T; Ogushi, F; Sone, S; Taketani, Y; Ueda, N; Yamamoto, S | 1 |
| Hauser, SD; Isakson, PC; Leahy, KM; Manning, PT; Masferrer, JL; Seibert, K; Smith, WG; Zweifel, BS | 1 |
| Arai, I; Futaki, N; Hamasaka, Y; Higuchi, S; Otomo, S; Takahashi, S | 1 |
| Arai, I; Futaki, N; Hamasaka, Y; Higuchi, S; Otomo, S; Takahashi, S; Yoshikawa, K | 1 |
| Arai, I; Futaki, N; Hamasaka, Y; Higuchi, S; Iizuka, H; Otomo, S; Yoshikawa, K | 1 |
| Cartwright, M; Charleson, S; Evans, J; Frank, J; Kargman, S; Mancini, J; O'Neill, G; Riendeau, D | 1 |
| Barrios-Rodiles, M; Belley, A; Chadee, K; Keller, K | 1 |
| Charette, L; Guay, J; Jones, TR; Misquitta, C; Reindeau, D | 1 |
| Fusamoto, H; Kamada, T; Kawano, S; Kobayashi, I; Nagano, K; Sawaoka, H; Takei, Y; Tsuji, S | 1 |
| Butcher, S; Coroneos, E; Dwivedi, R; Kester, M; Statt, C; Walenga, RW | 1 |
| Nozaki-Taguchi, N; Yamamoto, T | 1 |
| Naderali, EK; Poyser, NL | 1 |
| Kudo, I; Matsumoto, H; Murakami, M; Naraba, H; Oh-ishi, S; Ueno, A; Yamaki, K | 1 |
| Chulada, PC; Langenbach, R | 1 |
| Mue, S; Niki, H; Ohuchi, K; Tominaga, Y; Watanabe-Kobayashi, M | 1 |
| Kawaguchi, H; Koishihara, Y; Kubodera, N; Miyaura, C; Ohsugi, Y; Pilbeam, CC; Raisz, LG; Suda, T; Tai, H; Tamura, T | 1 |
| Harada, N; Murakami, K; Okabe, H; Okajima, K; Takatsuki, K; Tanaka, K; Uchiba, M | 1 |
| Béa, ML; Berdeaux, A; Beverelli, F; Giudicelli, JF; Puybasset, L | 1 |
| Fürstenberger, G; Hanke, B; Marks, F | 1 |
| Hara, A; Ino, N; Mori, H; Niwa, M; Yoshimi, N | 1 |
| Bell, RL; Hulkower, KI; Otis, ER; Wernimont, AK | 1 |
| Harada, Y; Hatanaka, K; Katori, M; Kawamura, M; Ogino, K | 1 |
| Claus, R; Deigner, HP; Fyrnys, B; Wolf, G | 1 |
| Fujii, E; Irie, K; Muraki, T; Ogawa, A; Ohba, K; Yamakawa, M; Yoshioka, T | 1 |
| Hirata, T; Kato, S; Takeuchi, K; Ukawa, H; Yamakuni, H | 1 |
| Hirata, T; Kitamura, M; Takeuchi, K; Ukawa, H | 1 |
| Iwata, K; Murakami, N; Naruse, T; Saito, T; Takase, H | 1 |
| Gunawan, ES; Hori, M; Kawano, S; Matsui, H; Nagano, K; Nakama, A; Sawaoka, H; Takei, Y; Tsuji, S; Tsujii, M | 1 |
| Lau, HY; Stenton, GR | 1 |
| Appleton, I; Bryant, CE; Mitchell, JA | 1 |
| Flanagan, AM; Lader, CS | 1 |
| Harada, Y; Hatanaka, K; Kawamura, M; Ogino, K; Ogino, M; Ohno, T; Saito, M; Yang, Q | 1 |
| Amann, R; Peskar, BA; Prenn, C; Schuligoi, R | 1 |
| Epstein, SE; Ferrans, VJ; Huang, ES; Speir, E; Yu, ZX | 1 |
| Barragán, M; Bellosillo, B; Castaño, E; Colomer, D; Gil, J; Montserrat, E; Piqué, M; Pons, G; Villamor, N | 1 |
| Gunawan, ES; Hori, M; Kawano, S; Nagano, K; Sawaoka, H; Takei, Y; Tsuji, S; Tsujii, M | 1 |
| Holland, E; Knox, AJ; Pang, L | 2 |
| Fujiyoshi, T; Kudo, I; Matsumoto, H; Murakami, M; Naraba, H; Oh-ishi, S; Ueno, A | 1 |
| Okabe, S; Shigeta, J; Takahashi, S | 1 |
| Kato, S; Takeuchi, K; Ukawa, H; Yamakuni, H | 1 |
| de Brum-Fernandes, AJ; Denault, JB; Leduc, R; Lora, M | 1 |
| Kita, T; Nakashima, T; Shimada, K; Suzumura, A; Takayanagi, T; Yonetani, Y | 1 |
| Dyer, RD; Gilbertsen, RB; Guglietta, A; Kraus, ER; Lesch, CA; Sanchez, B; Schrier, D; Song, Y | 1 |
| Brännström, M; Hedin, L; Hellberg, P; Mikuni, M; Pall, M; Peterson, CA; Peterson, CM; Richards, JS | 1 |
| Hori, M; Kawano, S; Murata, H; Sawaoka, H; Tsuji, S; Tsujii, M | 1 |
| Sakashita, Y; Yamamoto, T | 1 |
| Ciabattoni, G; Currò, D; Montuschi, P; Preziosi, P; Ragazzoni, E | 1 |
| Gillespie, MT; Inoue, K; Ishiyama, S; Itoh, K; Kamatani, N; Kotake, S; Martin, TJ; Matsuzaki, K; Saito, S; Suda, T; Takahashi, N; Udagawa, N | 1 |
| Koide, M; Murase, Y; Nishihara, T; Noguchi, T; Okahashi, N; Yamato, K | 1 |
| Chivers, J; Colville-Nash, PR; Gilroy, DW; Paul-Clark, MJ; Willis, D; Willoughby, DA | 1 |
| Hashizume, M; Kawanaka, H; Kishihara, F; Migou, S; Sugimachi, K; Tomikawa, M; Tsugawa, K | 1 |
| Langenbach, R; Morham, SG; Young, DA; Zhang, X | 1 |
| Danon, A; Rimon, G; Rosenstock, M | 1 |
| Kawai, M; Kawai, Y; Mashima, Y; Yamada, M | 1 |
| Escalante, B; Ferreri, NR; Salgado, LM; Sanchez, PL | 1 |
| Baik, EJ; Kim, EJ; Lee, SH; Moon, C | 1 |
| Itani, RM; Jones, MK; Levin, E; Peskar, BM; Sarfeh, IJ; Tarnawski, AS; Wang, H | 1 |
| Ehrlich, K; Gretzer, B; Maricic, N; Peskar, BM; Respondek, M; Schuligoi, R | 1 |
| Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Pajdo, R; Sliwowski, Z; Stachura, J | 1 |
| Gunawan, ES; Hori, M; Kawano, S; Sasaki, Y; Sawaoka, H; Tsuji, S; Tsujii, M | 1 |
| Wallace, JL | 1 |
| Bjorling, DE; Jerde, TJ; Nakada, SY; Saban, R | 1 |
| Boyan, BD; Dean, DD; Del Toro, F; Hardin, RR; Schwartz, Z; Sylvia, VL | 2 |
| Barnard, DS; Billings, SD; Cheng, L; Crowell, PL; Heilman, DK; Lin, A; Marshall, MS; Marshall, SJ; Sweeney, CJ; Yip-Schneider, MT | 1 |
| Fernández, AG; Godessart, N; Palacios, JM; Salcedo, C | 1 |
| Poyser, NL | 1 |
| Hirata, T; Kato, S; Kunikata, T; Takeuchi, K; Tanaka, A; Yamamoto, H | 1 |
| Araki, H; Mizoguchi, H; Sugamoto, S; Suzuki, K; Takeuchi, K; Umdeda, M | 1 |
| Davidson, ME; Lang, RJ | 1 |
| Gross, GA; Harris, KC; Koki, A; Masferrer, JL; Muglia, LJ; Nelson, DM; Olson, LM; Sadovsky, Y | 1 |
| Johnson, FC; Miller, MR; Poyser, NL | 1 |
| Goto, T; Motoyama, Y; Ochi, T | 1 |
| Hawcroft, G; Hull, MA; Smith, ML | 1 |
| Chikazu, D; Hakeda, Y; Kawaguchi, H; Kumegawa, M; Nakamura, K | 1 |
| Fujii, Y; Kai, M; Kawasaki, H; Matsui, H; Matsura, T; Yamada, K | 1 |
| Cohn, S; Riehl, T; Schloemann, S; Stenson, WF; Tessner, T | 1 |
| Chemtob, S; Clyman, RI; Heymann, MA; Lin, E; Roman, C; Takahashi, Y; Tse, MM | 1 |
| Tavares, IA | 1 |
| Floyd, RA; Jacob, JM; Kotake, Y; Tabatabaie, T; Waldon, AM | 1 |
| LaPointe, MC; Schuette, R | 1 |
| Gunawan, ES; Hori, M; Iijima, H; Kakiuchi, Y; Kawai, N; Kawano, S; Kimura, A; Sasaki, Y; Sawaoka, H; Sun, WH; Tsuji, S; Tsujii, M; Yasumaru, M | 1 |
| Elvin, JA; Matzuk, MM; Yan, C | 1 |
| Dunn, AJ; Swiergiel, AH | 1 |
| McIntire, LV; Menter, DG; Papadimitriou, MN | 1 |
| Fujita, T; Takahashi, S; Yamamoto, A | 2 |
| Ghosh, AK; Hirasawa, N; Niki, H; Ohuchi, K | 1 |
| Blum, A; Bohle, RM; Buerke, M; Fink, L; Grandel, U; Grimminger, F; Heep, M; Kraemer, HJ; Mayer, K; Seeger, W; Sibelius, U | 1 |
| Chou, R; Chou, YY; Hsu, MM; Tung, CS; Wong, CS | 1 |
| Fyhrquist, F; Kosonen, R; Nyman, T; Saijonmaa, O | 1 |
| Aitken, H; Poyser, NL | 1 |
| Danon, A; Rimon, G; Rosenstock, M; Rubin, M | 1 |
| Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Nakamura, T; Pajdo, R; Pawlik, M; Ptak, A; Schuppan, D | 1 |
| Abboud, HE; Bonacchi, A; Efsen, E; Gentilini, P; Laffi, G; Marra, F; Pastacaldi, S; Pinzani, M; Tosti-Guerra, C; Valente, AJ; Wenzel, UO | 1 |
| Amann, R; Peskar, BA; Schuligoi, R | 1 |
| Donahue, A; Lindström, CL; Luo, J; Miller, MW | 1 |
| Boyan, BD; Cochran, DL; Dean, DD; Liu, Y; Lohmann, CH; Schwartz, Z; Sisk, M; Sylvia, VL | 1 |
| Abid, A; Cipolletta, C; Jouzeau, J; Nédélec, E; Netter, P; Presle, N; Terlain, B | 1 |
| Malek, A; Sager, R; Schneider, H | 1 |
| Bielański, W; Bonior, J; Jachimczak, B; Jaworek, J; Konturek, PC; Konturek, SJ; Kot, M; Pawlik, WW; Sendur, R; Stachura, J; Tomaszewska, R | 1 |
| Endo, H; Ishikawa, I; Izumi, Y; Kondo, H; Nitta, H; Noguchi, K; Shitashige, M; Yotsumoto, Y | 1 |
| Mark, KS; Miller, DW; Trickler, WJ | 1 |
| Araki, H; Komoike, Y; Suzuki, K; Takeuchi, K; Umeda, M | 1 |
| Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Pajdo, R; Ptak, A; Sliwowski, Z | 1 |
| Gilroy, DW; Saunders, MA; Wu, KK | 1 |
| Grosset, C; Gualde, N; Harizi, H; Juzan, M; Rashedi, M | 1 |
| Chon, CY; Han, JH; Kang, JK; Kim, TI; Lee, KH; Lee, YC; Moon, YM; Park, IS | 1 |
| Alcaraz, MJ; Guillén, MI; Vicente, AM | 1 |
| Chakraborty, C; Lala, PK; Rozic, JG | 1 |
| Dorsey, R; Fulton, AM; Kundu, N; Yang, Q | 1 |
| Choudhry, MA; Fazal, N; Haque, F; Namak, SY; Ravindranath, T; Sayeed, MM | 1 |
| Calabrese, R; del Basso, P; Fabi, F; Stati, T | 1 |
| Corbett, L; Holland, E; Knox, AJ; Pang, L; Stocks, J; Zhu, YM | 1 |
| Di Rosa, M; Ialenti, A; Ianaro, A; Maffia, P; Pisano, B | 1 |
| Bari, F; Busija, DW; Domoki, F; Perciaccante, JV; Puskar, M | 1 |
| Albanese, C; D'Amico, M; Hawcroft, G; Hull, MA; Markham, AF; Pestell, RG | 1 |
| Ayoub, M; Panzer, U; Reinking, R; Shankland, SJ; Stahl, RA; Wolf, G; Zahner, G | 1 |
| Husain, SS; Jones, MK; Pai, R; Soreghan, B; Szabo, IL; Tarnawski, AS | 1 |
| Giap, AQ; Kawanaka, H; Pai, R; Szabo, IL; Tarnawski, AS | 1 |
| Husain, SS; Jones, MK; Kawanaka, H; Szabó, IL; Tarnawski, AS | 1 |
| Lozano, JJ; Pouplana, R; Ruiz, J | 1 |
| Hirsch-Ernst, KI; Kahl, GF; Rüdell, G; Schäfer, D; Ziemann, C | 1 |
| Henrion, D; Lévy, BI; Loufrani, L; Matrougui, K | 1 |
| Akamatsu, T; Futagami, S; Hiratsuka, T; Iizumi, T; Kobayashi, M; Miyake, K; Sakamoto, C; Shinoki, K; Tatsuguchi, A; Tsukui, T; Wada, K | 1 |
| Andrews, P; Djakiew, D; Krygier, S | 1 |
| Argenzio, RA; Blikslager, AT; Campbell, NB; Little, D; Young, KM; Zimmel, DN | 1 |
| Kuroda, E; Matsumoto, S; Matsumoto, T; Yamada, H; Yamada, T; Yamashita, U | 1 |
| Chang, HW; Han, CK; Kang, SS; Kim, HP; Kwak, WJ; Park, BK; Son, KH | 1 |
| Kolaczkowska, E; Plytycz, B; Seljelid, R; Shahzidi, S; van Rooijen, N | 1 |
| Burr, DB; Li, J; Turner, CH | 1 |
| Harada, N; Katsuragi, T; Okajima, K; Uchiba, M | 1 |
| Izon, DJ; Loftin, C; Spain, LM; Xu, H | 1 |
| Eriksson, E; Hellstrand, M; Nilsson, CL | 1 |
| Akotia, V; Giap, AQ; Hoa, NT; Ma, TY; Tarnawski, A | 1 |
| Corbett, L; Holland, E; Knox, AJ; Pang, L; Range, S; Rodgers, HC | 1 |
| Alonso, MJ; Briones, AM; Hernanz, R; Salaices, M; Tovar, S; Vila, E | 1 |
| Enomoto, U; Kanda, N; Nakai, K; Tani, K; Watanabe, S | 1 |
| Gunther, WM; Leffler, CW; Levine, V; Parfenova, H; Pourcyrous, M | 1 |
| Armstead, WM; Kulkarni, M | 1 |
| Higashi, M; Hiroki, J; Kunihiro, I; Matoba, T; Morikawa, K; Mukai, Y; Shimokawa, H; Takeshita, A; Talukder, HM | 1 |
| Bugajski, AJ; Bugajski, J; Gadek-Michalska, A | 1 |
| Burde, T; Rimon, G | 1 |
| Fukuda, Y; Futagami, A; Ishizaki, M; Kawana, S; Yamanaka, N | 1 |
| Barrachina, MD; Calatayud, S; Esplugues, JV; Felipo, V; García-Zaragozá, E; Hernández, C; Quintana, E | 1 |
| Campell, WB; Isbell, MA; Kajdacsy-Balla, A; Kaul, S; Lindholm, PF; Nithipatikom, K | 1 |
| Calixto, JB; El Sayah, M | 1 |
| Begay, CK; Gandolfi, AJ | 1 |
| Corbett, L; Knox, AJ; Nie, M; Pang, L | 1 |
| Andriantsitohaina, R; Chasserot, S; Mitolo-Chieppa, D; Potenza, MA; Randriamboavonjy, V; Schneider, F; Stoclet, JC; Tabernero, A; Wolf, P | 1 |
| Fischer, MB; Gruber, R; Karreth, F; Schöfnagl, M; Watzek, G | 1 |
| Moon, Y; Pestka, JJ | 1 |
| Bradbury, DA; Knox, AJ; Pang, L; Sánchez-Alcázar, JA | 1 |
| Bissonnette, EY; Castonguay, A; Proulx, LI; Therriault, MJ | 1 |
| Hori, M; Kitagawa, K; Matsumoto, M; Okano, H; Omura-Matsuoka, E; Sasaki, T; Sugiura, S; Tanaka, S; Yagita, Y | 1 |
| Kim, HJ; Kim, MH; Lee, SK; Min, YI; Seo, DW | 1 |
| Armstead, WM | 1 |
| Halter, F; Hoa, N; Ma, TY; Nakamura, T; Netzer, P; Nguyen, N; Tarnawski, AS | 1 |
| Alexander, JS; Itoh, M; Joh, T; Nomura, T; Ohara, H; Oshima, T; Sasaki, M; Seno, K; Takezono, Y; Yokoyama, Y | 1 |
| Bortz, E; Cole, S; Herschman, H; Jia, Q; Martinez-Guzman, D; Rudra-Ganguly, N; Sun, R; Symensma, TL; Wu, TT | 1 |
| Kennedy, JH; Korn, N; Thurston, RJ | 1 |
| Ishii, K; Kubota, Y; Nakahara, T; Saito, M; Sakamoto, K | 1 |
| Bugajski, AJ; Bugajski, J; Gadek-Michalska, A; Głód, R; Thor, P | 1 |
| Abe, M; Baranowska-Kortylewicz, J; Enke, CA; Kurizaki, T; Sanderson, SD | 1 |
| Chai, J; Chu, EC; Tarnawski, AS | 1 |
| Bagnato, A; Di Castro, V; Natali, PG; Nicotra, MR; Rosanò, L; Spinella, F | 1 |
| Jin, DZ; Yang, XN; Zhang, WY; Zhu, XZ | 1 |
| Inoue, A; Nakata, Y; Oshita, K; Tang, HB | 1 |
| Bugajski, J; Gadek-Michalska, A | 1 |
| Ishikawa, I; Noguchi, K; Ruwanpura, SM; Yan, M; Yoshida, N | 1 |
| Bjorling, DE; Calamon-Dixon, JL; Jerde, TJ; Nakada, SY | 1 |
| Aoki, A; Ishikawa, I; Noguchi, K; Pourzarandian, A; Ruwanpura, SM; Watanabe, H | 1 |
| Adeagbo, AS; Igbo, IN; Joshua, IG; Oriowo, MA; Patel, D; Sun, X; Wang, Y; Zhang, X | 1 |
| Bari, F; Domoki, F; Nagy, K; Temesvári, P | 1 |
| Bradbury, D; Corbett, L; Knox, AJ; Pang, L; Stocks, J | 1 |
| Jiang, X; Nakajima, Y; Ohno, K; Sato, S; Shi, E; Yue, H | 1 |
| Ishikawa, I; Noguchi, K; Ruwanpura, SM; Yan, M | 1 |
| Boltz-Nitulescu, G; Jensen-Jarolim, E; Matejka, M; Rausch, WD; Rausch-Fan, X; Schedle, A; Ulm, C | 1 |
| Babaev, VR; Burleigh, ME; Fazio, S; Linton, MF; Major, AS; McCaleb, JL; Morrow, JD; Oates, JA; Yancey, PG | 1 |
| Iwagaki, H; Jikuhara, A; Mori, S; Nishibori, M; Takahashi, HK; Tanaka, N; Yoshii, M | 1 |
| Feletou, M; Gluais, P; Lonchampt, M; Morrow, JD; Vanhoutte, PM | 1 |
| Arias, C; Ferrera, P | 1 |
| Briones, AM; Giraldo, J; Montoya, N; Vila, E | 1 |
| Claassen, N; Coetzee, M; Haag, M; Kruger, MC | 1 |
| Cullen, DM; Genrich, MA; Killpack, B; Lee, Y; Marx, DB; Narayana, N; Reinhardt, RA; Schmid, MJ; Stein, D | 1 |
| Blais, V; Rivest, S; Turrin, NP | 1 |
| Iwagaki, H; Katsuno, G; Mizuno, K; Mori, S; Nishibori, M; Saito, S; Takahashi, HK; Tanaka, N; Yagi, T; Yoshino, T | 1 |
| Bernstein, SH; Chiorazzi, N; Felgar, RE; Kaur, K; Phipps, RP; Pollock, SJ; Ryan, EP | 1 |
| Battastini, AM; Bernardi, A; Delgado-Cañedo, A; Jacques-Silva, MC; Lenz, G | 1 |
| Graves, E; McCarthy, DO; Ramsay, E | 1 |
| Edwards, RM; Evans, C; Hieble, JP; McCafferty, GP; Wibberley, A | 1 |
| Bartuzi, Z; McCallum, R; Poplawski, C; Sarosiek, J; Sosnowski, D; Szaflarska-Popławska, A | 1 |
| Harada, N; Okajima, K; Uchiba, M | 1 |
| Ford, GD; Vaughan, JE; Walsh, SW | 1 |
| Chandran, B; Naranatt, PP; Raghu, H; Sadagopan, S; Sharma-Walia, N; Sivakumar, R; Smith, MM; Veettil, MV | 1 |
| Katsu, K; Kubota, T; Mori, H; Nakahari, T; Nakanishi, Y; Nakano, T; Shimamoto, C | 1 |
| Bellido, C; Gaytán, F; Gaytán, M; Morales, C; Sánchez-Criado, JE | 1 |
| Ito, S; Ito, Y; Kondo, M; Kume, H; Naruse, K; Oguma, T; Shimokata, K; Suki, B | 1 |
| Chai, J; Huang, RH; Tarnawski, AS | 1 |
| Baumann, K; Haass, C; Narlawar, R; Pérez Revuelta, BI; Schmidt, B; Steiner, H | 1 |
| Harada, N; Okajima, K; Taoka, Y | 1 |
| Haneji, T; Nagata, T; Shinohara, H; Yoshida, K | 1 |
| Fukutake, M; Iizuka, S; Imamura, S; Ishige, A; Ishimatsu, M; Kase, Y; Miura, N; Nakamura, Y; Ohtake, N; Takeda, S; Tsuchiya, N; Watanabe, K; Yamamoto, M | 1 |
| Aras-López, R; Arroyo-Villa, I; Balfagón, G; Blanco-Rivero, J; Ferrer, M; Márquez-Rodas, I; Xavier, FE | 1 |
| Arai, I; Futaki, N; Hashimoto, Y; Honma, Y; Nakaike, S; Sakurai, T; Sugimoto, M | 1 |
| Freeman, LC; Ganta, S; Gilmour, RF; Hunter, R; Koch, D; Lillich, JD; McCoy, A; Narvaez, DF; Silver, K; von Stein, FB; Young, S | 1 |
| Hentunen, T; Kellinsalmi, M; Lehenkari, P; Lehtonen, S; Leskelä, HV; Parikka, V; Risteli, J; Selander, K; Väänänen, K | 1 |
| Birkenmeier, K; Felix, SB; Janke, I; Krieg, T; Labitzke, C; Landsberger, M; Prange, T; Schunck, WH; Stangl, V; Staudt, A; Trimpert, C | 1 |
| Bari, F; Berczi, S; Farkas, E; Institoris, A; Sule, Z | 1 |
| Hirate, K; Irifune, M; Ishida, T; Nakamura, N; Nishikawa, T; Sato, T; Tanaka, K | 1 |
| Ge, Y; Kohan, DE; Strait, KA; Stricklett, PK; Yang, T | 1 |
| Ansari, HR; Mustafa, SJ; Nadeem, A; Tilley, SL | 1 |
| Bagchi, IC; Bagchi, MK; Demayo, FJ; Kim, J; Li, Q; Lydon, JP; Sato, M | 1 |
| Helmer, KS; Mercer, DW; Suliburk, JW; West, SD | 1 |
| Freeman, LC; Ganta, S; Lillich, JD; Narvaez, D; Raveendran, NN; Silver, K; Weng, K | 1 |
| Cuzzocrea, S; Di Paola, R; Esposito, E; Matuschak, GM; Mazzon, E; Ndengele, MM; Salvemini, D | 1 |
| Adleff, V; Barna, G; Budai, B; Jeney, A; Kralovánszky, J; L Komlósi, V; Pap, E; Réti, A | 1 |
| Kokoska, L; Landa, P; Marsik, P; Pribylova, M; Vanek, T | 1 |
| Clapper, ML; Foreman, JE; Gonzalez, FJ; McGinnis, KS; Peters, JM; Rigas, B; Sorg, JM; Williams, JL | 1 |
| Cascioferro, S; Cusimano, MG; Maggio, B; Plescia, F; Plescia, S; Raffa, D; Raimondi, MV | 1 |
| Budai, B; Jeney, A; Kralovánszky, J; Pap, E; Réti, A; Zalatnai, A | 1 |
| Adleff, V; Budai, B; Jeney, A; Kralovánszky, J; Pap, E; Réti, A | 1 |
| Adachi, S; Akema, T; Fujioka, H; Kakehashi, C; Matsuwaki, T; Nishihara, M | 1 |
| Belin de Chantemèle, EJ; Guihot, AL; Henrion, D; Loufrani, L; Toutain, B; Vessières, E | 1 |
| Asbun-Bojalil, J; Castillo, EF; Castillo-Henkel, C; Castillo-Hernandez, MC; Guevara-Balcazar, G; Lopez, RM; Lopez-Sanchez, P | 1 |
| Brownrigg, M; Gledhill, K; Haylett, AK; Masoodi, M; Nicolaou, A; Rhodes, LE; Thody, AJ; Tobin, DJ | 1 |
| Anantharamaiah, GM; Dai, L; Datta, G; Gupta, H; Honavar, J; Modi, S; Palgunachari, M; Patel, R; White, CR; Wyss, JM; Zhang, Z | 1 |
| Freeman, LC; Leloup, L; Lillich, JD; Silver, K; Wells, A | 1 |
| Fu, SM; Guan, SM; He, JJ; Zhang, M | 1 |
| Réti, A | 1 |
| Akaogi, J; Ito, H; Kanaji, T; Komagata, T; Maruyama, T; Mitomi, H; Mori, T; Nomoto, S; Ozaki, S; Shibata-Nozaki, T; Yamada, H | 1 |
| Bandyopadhyay, SK; Chatterjee, A; Chatterjee, S; Chattopadhyay, S; Das, S; Saha, A | 1 |
| Desormaux, A; Freeman, LC; Lillich, JD; Silver, K | 1 |
| Asano, K; Ito, Y; Kim, S; Matsukawa, N; Yamamoto, K; Yamatodani, A | 1 |
| Banat, GA; Dahlem, G; Eul, B; Fink, L; Goldmann, T; Grandel, U; Grimminger, F; Hattar, K; Lang, DS; Savai, R; Schermuly, RT; Schmall, A; Seeger, W; Sibelius, U; Subtil, FS; Vollmer, E; Wilhelm, J | 1 |
| de Queiroz, DB; Duarte, GP; Ramos-Alves, FE; Santos-Rocha, J; Xavier, FE | 1 |
| Ma, Y; Matsuwaki, T; Nishihara, M; Yamanouchi, K | 1 |
| Auricchio, S; Bergamo, P; Bozzella, G; David, C; Luongo, D; Maurano, F; Mazzarella, G; Palmieri, G; Rossi, M; Rotondi Aufiero, V; Troncone, R | 1 |
| Cruz, M; García-Macedo, R; Gómez-Zamudio, JH; Ibarra-Barajas, M; Kumate, J; Lázaro-Suárez, M | 1 |
| Botelho, T; de Batista, PR; Padilha, AS; Ribeiro-Júnior, RF; Simões, FV; Vassallo, DV | 1 |
| Bawa, B; Lillich, JD; Littlejohn, A; Silver, K; Thomas, L | 1 |
| Kawaguchi-Ihara, N; Murohashi, I; Nakamura, S; Suzuki, K; Tohda, S; Zhang, YI; Zhao, Y | 1 |
| Cushen, SC; Goulopoulou, S; Osikoya, O; Ricci, CA | 1 |
2 review(s) available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and indomethacin
| Article | Year |
|---|---|
Anti-inflammatory activity of triazine derivatives: A systematic review.
Topics: Animals; Anti-Inflammatory Agents; Humans; Inflammation; Structure-Activity Relationship; Triazines | 2019 |
Distribution and expression of cyclooxygenase (COX) isoenzymes, their physiological roles, and the categorization of nonsteroidal anti-inflammatory drugs (NSAIDs).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Controlled Clinical Trials as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etodolac; Gene Expression; Humans; Ibuprofen; Indomethacin; Isoenzymes; Meloxicam; Membrane Proteins; Naproxen; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thiazines; Thiazoles | 1999 |
265 other study(ies) available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and indomethacin
| Article | Year |
|---|---|
1,2-Diarylcyclopentenes as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase Inhibitors; Cyclopentanes; Dose-Response Relationship, Drug; Edema; Indomethacin; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Structure; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Sulfonamides; Sulfones | 1995 |
Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally active COX-2 inhibitors.
Topics: Administration, Oral; Animals; Arthritis, Experimental; Cyclooxygenase Inhibitors; Cyclopentanes; Mice; Rats | 1994 |
Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis.
Topics: Animals; Biological Assay; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Isoenzymes; Kinetics; Placenta; Prostaglandin Antagonists; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sheep | 1998 |
Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis.
Topics: Animals; Cattle; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; In Vitro Techniques; Isoenzymes; Plantago; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sheep; Triterpenes; Ursolic Acid | 1998 |
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Edema; Gastric Mucosa; Humans; Hyperalgesia; Isoenzymes; Male; Membrane Proteins; Mice; Oxazoles; Phenols; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Structure-Activity Relationship; Thiazoles | 1999 |
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Carrageenan; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Edema; Gastric Mucosa; Humans; Hyperalgesia; In Vitro Techniques; Isoenzymes; Male; Membrane Proteins; Mice; Phenols; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sheep; Stomach Ulcer; Structure-Activity Relationship; Thiadiazoles | 1999 |
Synthesis and pharmacological evaluation of some 8-cyanopyrido[3', 2':4,5]thieno[3,2-d]triazine derivatives as inhibitors of nitric oxide and eicosanoid biosynthesis.
Topics: Animals; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Isoenzymes; Macrophages, Peritoneal; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship; Thiophenes; Triazines | 1999 |
Novel antiarthritic agents with 1,2-isothiazolidine-1,1-dioxide (gamma-sultam) skeleton: cytokine suppressive dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Blood Platelets; Cyclic S-Oxides; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Edema; Female; Gastric Mucosa; Humans; Interleukin-1; Isoenzymes; Leukotriene B4; Lipoxygenase Inhibitors; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Lew; Structure-Activity Relationship; Synovial Membrane; Thiazoles | 2000 |
Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.
Topics: Acrolein; Alkaloids; Animals; Anthraquinones; Aspirin; Biological Assay; Catalysis; Cinnamomum zeylanicum; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Eugenol; Flavonoids; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Kinetics; Lactones; Models, Molecular; Nitrobenzenes; Oleanolic Acid; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Pyrogallol; Steroids; Sulfonamides; Sulfones; Syzygium; Terpenes; Triterpenes; Ursolic Acid | 2002 |
Expanding the ChemGPS chemical space with natural products.
Topics: Biological Products; Combinatorial Chemistry Techniques; Computer Graphics; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship | 2005 |
Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation.
Topics: Animals; Animals, Genetically Modified; beta Catenin; Cell Differentiation; Dinoprostone; Gene Expression Regulation; Humans; K562 Cells; Nitrobenzenes; Oncogene Proteins; Small Molecule Libraries; Sulfonamides; Transcription Factors; Zebrafish; Zebrafish Proteins | 2009 |
Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation.
Topics: Arachidonate 5-Lipoxygenase; Biphenyl Compounds; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Humans; Leukocytes; Leukotriene B4; Lignans; Magnolia; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship | 2009 |
Synthesis and cyclooxygenase inhibitory activities of some N-acylhydrazone derivatives of isoxazolo[4,5-d]pyridazin-4(5H)-ones.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Humans; Hydrazones; Models, Molecular; Molecular Conformation; Prostaglandin-Endoperoxide Synthases; Pyridazines | 2010 |
Derivatives of schisandrin with increased inhibitory potential on prostaglandin E(2) and leukotriene B(4) formation in vitro.
Topics: Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Circular Dichroism; Cyclooctanes; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Indicators and Reagents; Leukotriene B4; Lignans; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Polycyclic Compounds; Schisandra; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship | 2010 |
Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Austria; Benzofurans; Cyclooxygenase 1; Edema; Intramolecular Oxidoreductases; Krameriaceae; Lignans; Male; Mice; NF-kappa B; Plant Roots; Prostaglandin-E Synthases | 2011 |
Molecular modeling, synthesis and screening of some new 4-thiazolidinone derivatives with promising selective COX-2 inhibitory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Indomethacin; Magnetic Resonance Spectroscopy; Molecular Docking Simulation; Nitrobenzenes; Recombinant Proteins; Sheep; Structure-Activity Relationship; Sulfonamides; Thiazolidines | 2012 |
1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamides: synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity.
Topics: Animals; Anisoles; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Hydrazines; Male; Models, Molecular; Molecular Structure; Rats; Stomach Ulcer; Structure-Activity Relationship; Triazoles | 2014 |
1,2-Diaryl-2-hydroxyiminoethanones as dual COX-1 and β-amyloid aggregation inhibitors: biological evaluation and in silico study.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Design; Humans; Ketones; Male; Mice; Molecular Dynamics Simulation; Peptide Fragments; Protein Aggregates; Protein Aggregation, Pathological; Sheep | 2015 |
Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Drug Design; Edema; Humans; Inflammation; Mice; Molecular Docking Simulation; Molecular Dynamics Simulation; Naproxen; Nociception; Pain; Pain Measurement; Structure-Activity Relationship; Thiazoles; Thiones; Triazoles | 2015 |
Synthesis of new 4-phenylpyrimidine-2(1H)-thiones and their potency to inhibit COX-1 and COX-2.
Topics: Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Thiones | 2015 |
Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase.
Topics: Animals; Arachidonic Acid; Baculoviridae; Cloning, Molecular; Cyclooxygenase Inhibitors; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation, Enzymologic; Humans; Indomethacin; Nitrobenzenes; Oxygen Consumption; Prostaglandin-Endoperoxide Synthases; Recombinant Proteins; Spodoptera; Sulfonamides; Thiophenes; Time Factors | 1995 |
Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms.
Topics: Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Flurbiprofen; Humans; Indomethacin; Isoenzymes; Kinetics; Meclofenamic Acid; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Recombinant Proteins; Sulfonamides | 1995 |
Induction of cyclooxygenase-2 is responsible for interleukin-1 beta-dependent prostaglandin E2 synthesis by human lung fibroblasts.
Topics: Base Sequence; Cells, Cultured; Cycloheximide; Dactinomycin; Dexamethasone; Dinoprostone; DNA Primers; Enzyme Induction; Fibroblasts; Gene Expression; Humans; In Vitro Techniques; Indomethacin; Interleukin-1; Interleukin-4; Lung; Molecular Sequence Data; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides | 1995 |
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.
Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase Inhibitors; Dexamethasone; Gastric Mucosa; Indomethacin; Inflammation; Isoenzymes; Male; Molecular Sequence Data; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Inbred Lew; Sulfonamides | 1994 |
Selective inhibition of NS-398 on prostanoid production in inflamed tissue in rat carrageenan-air-pouch inflammation.
Topics: 6-Ketoprostaglandin F1 alpha; Air Sacs; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dinoprostone; Exudates and Transudates; Gastric Mucosa; Indomethacin; Inflammation; Kidney; Nitrobenzenes; Prostaglandins; Rats; Respiratory Tract Diseases; Sulfonamides; Thromboxane B2 | 1993 |
Effect of NS-398, a new nonsteroidal anti-inflammatory agent, on gastric ulceration and acid secretion in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Indomethacin; Male; Nitrobenzenes; Peptic Ulcer; Rats; Rats, Wistar; Stress, Physiological; Sulfonamides | 1993 |
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygenase Inhibitors; Diclofenac; Edema; Fever; Ibuprofen; In Vitro Techniques; Indomethacin; Male; Nitrobenzenes; Pain; Phenylpropionates; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach Ulcer; Sulfonamides | 1993 |
Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts.
Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Digestive System; Dogs; Endothelium; Humans; Immunoblotting; Immunohistochemistry; Indomethacin; Isoenzymes; Macaca mulatta; Macrophages; Microsomes; Molecular Sequence Data; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Saimiri; Sulfonamides | 1996 |
Nonsteroidal antiinflammatory drugs inhibit cyclooxygenase-2 enzyme activity but not mRNA expression in human macrophages.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gene Expression; Humans; Indomethacin; Isoenzymes; Lipopolysaccharides; Macrophages; Membrane Proteins; Naproxen; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides | 1996 |
Involvement of cyclooxygenase 2 (COX-2) in intrinsic tone of isolated guinea pig trachea.
Topics: Animals; Cartilage; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Electric Stimulation; Electrophoresis, Polyacrylamide Gel; Guinea Pigs; Histamine; Immunoblotting; In Vitro Techniques; Indomethacin; Isoenzymes; Lipoxygenase Inhibitors; Muscle Tonus; Muscle, Smooth; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Trachea | 1995 |
Evidences for involvement of cyclooxygenase-2 in proliferation of two gastrointestinal cancer cell lines.
Topics: Cell Division; Cell Line; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gastrointestinal Neoplasms; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Isoenzymes; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Stomach Neoplasms; Sulfonamides; Tumor Cells, Cultured | 1996 |
Constitutive expression of prostaglandin endoperoxide G/H synthetase (PGHS)-2 but not PGHS-1 in hum an tracheal epithelial cells in vitro.
Topics: Adrenal Cortex Hormones; Blotting, Northern; Cells, Cultured; Culture Media, Serum-Free; Cycloheximide; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Epithelial Cells; Epithelium; Growth Substances; Humans; Immunoblotting; Indomethacin; Isoenzymes; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Trachea | 1996 |
Analysis of the effects of cyclooxygenase (COX)-1 and COX-2 in spinal nociceptive transmission using indomethacin, a non-selective COX inhibitor, and NS-398, a COX-2 selective inhibitor.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Indomethacin; Injections, Spinal; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfonamides | 1996 |
Effect of a selective prostaglandin H synthase-2 inhibitor (NS-398) on prostaglandin production by the guinea-pig uterus.
Topics: Animals; Cells, Cultured; Culture Techniques; Cyclooxygenase Inhibitors; Endometrium; Epithelium; Female; Guinea Pigs; Indomethacin; Myometrium; Nitrobenzenes; Prostaglandin H2; Prostaglandins; Prostaglandins H; Radioimmunoassay; Sulfonamides; Uterus | 1996 |
Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages.
Topics: Animals; Cells, Cultured; Cycloheximide; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dactinomycin; Dinoprostone; Enzyme Induction; Indomethacin; Intramolecular Oxidoreductases; Isoenzymes; Isomerases; Kinetics; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Male; Nitrobenzenes; Prostaglandin D2; Prostaglandin-E Synthases; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfonamides; Thromboxane B2 | 1997 |
Differential inhibition of murine prostaglandin synthase-1 and -2 by nonsteroidal anti-inflammatory drugs using exogenous and endogenous sources of arachidonic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Calcimycin; Cell Line; Cell Survival; CHO Cells; Cricetinae; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Indomethacin; Isoenzymes; Kinetics; Membrane Proteins; Mice; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 1997 |
Possible participation of cyclooxygenase-2 in the recurrence of allergic inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Exudates and Transudates; Granulation Tissue; Hypersensitivity; Indomethacin; Inflammation; Isoenzymes; Leukocytes; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors | 1997 |
Transcriptional induction of cyclooxygenase-2 in osteoblasts is involved in interleukin-6-induced osteoclast formation.
Topics: Aging; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Blotting, Northern; Bone Marrow Cells; Cells, Cultured; Coculture Techniques; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; DNA Primers; Enzyme Induction; Indomethacin; Interleukin-1; Interleukin-6; Isoenzymes; Male; Mice; Mice, Inbred Strains; Nitrobenzenes; Osteoblasts; Osteoclasts; Polymerase Chain Reaction; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Receptors, Interleukin; Receptors, Interleukin-6; Sulfonamides; Transcription, Genetic | 1997 |
Novel role of prostacyclin in stress-induced gastric mucosal lesion formation in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Epoprostenol; Gastric Mucosa; Iloprost; Indomethacin; Isoenzymes; Leukopenia; Male; Mechlorethamine; Nitrobenzenes; Peroxidase; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Restraint, Physical; Stress, Psychological; Sulfonamides; Time Factors | 1997 |
Chronic inhibition of NO synthase enhances the production of prostacyclin in coronary arteries through upregulation of the cyclooxygenase type 1 isoform.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Bradykinin; Coronary Vessels; Cyclooxygenase 1; Dogs; Enzyme Induction; Enzyme Inhibitors; Epoprostenol; In Vitro Techniques; Indans; Indomethacin; Isoenzymes; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Nitrobenzenes; omega-N-Methylarginine; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Up-Regulation | 1997 |
Relationship between TGF alpha-induced DNA synthesis and prostaglandin synthesis in human HaCaT keratinocytes.
Topics: Arachidonic Acid; Cell Division; Cell Line; Cyclooxygenase Inhibitors; DNA; Humans; Indomethacin; Keratinocytes; Nitrobenzenes; Prostaglandins; Sulfonamides; Time Factors; Transforming Growth Factor alpha | 1996 |
Apoptosis induced by NS-398, a selective cyclooxygenase-2 inhibitor, in human colorectal cancer cell lines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Division; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; DNA Fragmentation; Dose-Response Relationship, Drug; Humans; Ibuprofen; Indomethacin; Isoenzymes; Membrane Proteins; Nitrobenzenes; Piroxicam; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Tumor Cells, Cultured | 1997 |
Stimulus dependence of non-steroidal antiinflammatory drug potency in a cellular assay of prostaglandin H synthase-2.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Drug Interactions; Humans; Ibuprofen; Indans; Indomethacin; Interleukin-1; Meclofenamic Acid; Nitrobenzenes; Okadaic Acid; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides; Tumor Necrosis Factor-alpha | 1997 |
Evaluation of pharmacological profile of meloxicam as an anti-inflammatory agent, with particular reference to its relative selectivity for cyclooxygenase-2 over cyclooxygenase-1.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Gastric Mucosa; In Vitro Techniques; Indomethacin; Isoenzymes; Male; Meloxicam; Membrane Proteins; Nitrobenzenes; Piroxicam; Pleurisy; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfonamides; Therapeutic Equivalency; Thiazines; Thiazoles | 1997 |
Oxidized low density lipoprotein stimulates protein kinase C (PKC) activity and expression of PKC-isotypes via prostaglandin-H-synthase in P388D1 cells.
Topics: Acetates; Animals; Cyclooxygenase Inhibitors; Cytosol; Enzyme Activation; Enzyme Induction; Indomethacin; Isoenzymes; Leukemia P388; Lipoproteins, LDL; Lipoxygenase Inhibitors; Macrophages; Masoprocol; Mice; Neoplasm Proteins; Nitrobenzenes; Oxidation-Reduction; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Processing, Post-Translational; Pyrroles; Serum Albumin, Bovine; Sulfonamides | 1997 |
Role of nitric oxide, prostaglandins and tyrosine kinase in vascular endothelial growth factor-induced increase in vascular permeability in mouse skin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Cycloheximide; Dinoprostone; Endothelial Growth Factors; Enzyme Inhibitors; Extravasation of Diagnostic and Therapeutic Materials; Genistein; Guanidines; Indomethacin; Lymphokines; Male; meta-Aminobenzoates; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrobenzenes; Phenols; Prostaglandins; Protein-Tyrosine Kinases; Salicylates; Skin; Stereoisomerism; Sulfonamides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1997 |
Cyclo-oxygenase isozymes in mucosal ulcergenic and functional responses following barrier disruption in rat stomachs.
Topics: Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Edema; Gastric Acid; Gastric Mucosa; Indomethacin; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Rats; Stomach; Stomach Ulcer; Sulfonamides; Taurocholic Acid | 1997 |
Effects of selective cyclooxygenase-2 inhibitors on alkaline secretory and mucosal ulcerogenic responses in rat duodenum.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bicarbonates; Cyclooxygenase Inhibitors; Dinoprostone; Duodenal Ulcer; Duodenum; Gastric Acid; Histamine; Hydrogen-Ion Concentration; Indomethacin; Intestinal Mucosa; Male; Nitrobenzenes; Rats; Rats, Sprague-Dawley; Sulfonamides | 1997 |
Comparative study of the effects of indomethacin and NS-398, a selective cyclooxygenase 2 inhibitor, on duodenal bicarbonate secretion induced by luminal acidification in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bicarbonates; Cyclooxygenase 2; Duodenum; Gastric Acid; Gastric Mucosa; In Vitro Techniques; Indomethacin; Isoenzymes; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfonamides | 1997 |
Expression of the cyclooxygenase-2 gene in gastric epithelium.
Topics: Animals; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gastric Mucosa; Gene Expression; Hydrochloric Acid; Indomethacin; Isoenzymes; Male; Nitrobenzenes; Peroxidases; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfonamides; Time Factors | 1997 |
Effects of non-steroidal anti-inflammatory drugs and cyclooxygenase-2 specific inhibitors on mediator release from rat peritoneal mast cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Activation; Flurbiprofen; Histamine Release; Ibuprofen; Immunoglobulin E; Indans; Indomethacin; Isoenzymes; Male; Mast Cells; Naphthaleneacetic Acids; Nitrobenzenes; Peritoneal Cavity; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfonamides | 1998 |
Vascular endothelial growth factor upregulates constitutive cyclooxygenase 1 in primary bovine and human endothelial cells.
Topics: Animals; Blotting, Western; Cattle; Cell Division; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Endothelial Growth Factors; Endothelium, Vascular; Humans; Indomethacin; Isoenzymes; Lymphokines; Membrane Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Prostaglandin E2, interleukin 1alpha, and tumor necrosis factor-alpha increase human osteoclast formation and bone resorption in vitro.
Topics: Antibodies, Monoclonal; Bone Marrow Cells; Bone Resorption; Cell Count; Cell Division; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Humans; Indomethacin; Interleukin-1; Macrophage Colony-Stimulating Factor; Macrophages; Nitrobenzenes; Osteoclasts; Sulfonamides; Tumor Necrosis Factor-alpha | 1998 |
Differing profiles of prostaglandin formation inhibition between selective prostaglandin H synthase-2 inhibitors and conventional NSAIDs in inflammatory and non-inflammatory sites of the rat.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Gastric Juice; Indomethacin; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Pleurisy; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Sodium Chloride; Sulfonamides; Thromboxane B2 | 1998 |
Effects of the cyclooxygenase-2 inhibitor NS-398 on thromboxane and leukotriene synthesis in rat peritoneal cells.
Topics: Animals; Cyclooxygenase Inhibitors; Dinoprostone; Indomethacin; Leukotriene B4; Leukotriene C4; Lipopolysaccharides; Nitrobenzenes; Peritoneal Cavity; Peritoneal Lavage; Rats; Rats, Sprague-Dawley; Sulfonamides; Thromboxane B2 | 1998 |
Aspirin attenuates cytomegalovirus infectivity and gene expression mediated by cyclooxygenase-2 in coronary artery smooth muscle cells.
Topics: Antiviral Agents; Aspirin; Cells, Cultured; Coronary Vessels; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytomegalovirus; Cytopathogenic Effect, Viral; Dexamethasone; Dinoprostone; Free Radical Scavengers; Gene Expression Regulation, Viral; Humans; Immediate-Early Proteins; Indomethacin; Isoenzymes; Membrane Proteins; Muscle Proteins; Muscle, Smooth, Vascular; NF-kappa B; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Reactive Oxygen Species; Sodium Salicylate; Sulfonamides; Transcriptional Activation; Viral Proteins; Virus Replication | 1998 |
Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells.
Topics: Aged; Amino Acid Chloromethyl Ketones; Annexins; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; B-Lymphocytes; Cell Survival; Cyclooxygenase Inhibitors; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Fragmentation; Enzyme Activation; Female; Humans; Indomethacin; Ketorolac; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Neoplasm Proteins; Nitrobenzenes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Salicylates; Salicylic Acid; Sulfonamides; Tolmetin; Tumor Cells, Cultured | 1998 |
Cyclooxygenase-2 inhibitors suppress the growth of gastric cancer xenografts via induction of apoptosis in nude mice.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Apoptosis; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; Indomethacin; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron; Neoplasm Transplantation; Nitrobenzenes; Stomach Neoplasms; Sulfonamides; Transplantation, Heterologous; Tumor Cells, Cultured | 1998 |
Impaired cAMP production in human airway smooth muscle cells by bradykinin: role of cyclooxygenase products.
Topics: Adult; Bradykinin; Calcimycin; Cells, Cultured; Cyclic AMP; Cycloheximide; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dactinomycin; Dexamethasone; Dinoprostone; Enzyme Induction; Female; Humans; Indomethacin; Isoenzymes; Isoproterenol; Male; Membrane Proteins; Middle Aged; Muscle, Smooth; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Receptor, Bradykinin B2; Receptors, Bradykinin; Sulfonamides; Trachea | 1998 |
Induction of cyclooxygenase-2 causes an enhancement of writhing response in mice.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Induction; Exudates and Transudates; Indans; Indomethacin; Isoenzymes; Male; Mice; Mice, Inbred ICR; Nitrobenzenes; Pain; Pain Measurement; Peritoneum; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 1998 |
Role of cyclooxygenase-2 in the healing of gastric ulcers in rats.
Topics: Animals; Cyclooxygenase 2; Dinoprostone; Indomethacin; Isoenzymes; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; RNA, Messenger; Stomach Ulcer; Sulfonamides | 1998 |
Effects of cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal antiinflammatory drugs on mucosal ulcerogenic and healing responses of the stomach.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Mucosa; Hypothermia, Induced; Indomethacin; Isoenzymes; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Nitric Oxide; Nitrobenzenes; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stomach Ulcer; Sulfonamides; Wound Healing | 1998 |
Systematic pharmacological approach to the characterization of NSAIDs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cells, Cultured; COS Cells; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Activation; Genetic Vectors; Humans; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Mefenamic Acid; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Time Factors; Transfection | 1998 |
Cyclooxygenase 2 expression by endothelin-1-stimulated mouse resident peritoneal macrophages in vitro.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Indomethacin; Isoenzymes; Macrophages, Peritoneal; Mice; Nitrobenzenes; Oligopeptides; Peptides, Cyclic; Piperidines; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 1998 |
Effects of novel anti-inflammatory compounds on healing of acetic acid-induced gastric ulcer in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Mucosa; Indomethacin; Isoenzymes; Lipoxygenase Inhibitors; Male; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stomach Ulcer; Sulfonamides | 1998 |
The selective prostaglandin endoperoxide synthase-2 inhibitor, NS-398, reduces prostaglandin production and ovulation in vivo and in vitro in the rat.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chorionic Gonadotropin; Cyclooxygenase Inhibitors; Female; In Vitro Techniques; Indomethacin; Luteinizing Hormone; Nitrobenzenes; Ovarian Follicle; Ovulation; Prostaglandins; Rats; Rats, Sprague-Dawley; Sulfonamides | 1998 |
Role of cyclo-oxygenase-2 induction in interleukin-1beta induced attenuation of cultured human airway smooth muscle cell cyclic AMP generation in response to isoprenaline.
Topics: Adrenergic beta-Agonists; Adult; Arachidonic Acid; Cell Survival; Cells, Cultured; Cyclic AMP; Cycloheximide; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dactinomycin; Dexamethasone; Dinoprostone; Enzyme Induction; Female; Glucocorticoids; Humans; Indomethacin; Interferon-gamma; Interleukin-1; Isoenzymes; Isoproterenol; Male; Membrane Proteins; Middle Aged; Muscle, Smooth; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein Synthesis Inhibitors; Sulfonamides; Trachea; Tumor Necrosis Factor-alpha | 1998 |
Effects of NSAIDs on proliferation of gastric cancer cells in vitro: possible implication of cyclooxygenase-2 in cancer development.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Blotting, Northern; Blotting, Western; Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Isoenzymes; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Stomach Neoplasms; Sulfonamides; Tumor Cells, Cultured | 1998 |
COX-2 inhibitor prevents the development of hyperalgesia induced by intrathecal NMDA or AMPA.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Hyperalgesia; Indomethacin; Injections, Spinal; Isoenzymes; Male; N-Methylaspartate; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfonamides | 1998 |
Anaphylaxis increases 8-iso-prostaglandin F2alpha release from guinea-pig lung in vitro.
Topics: Anaphylaxis; Animals; Bronchoconstriction; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; F2-Isoprostanes; Guinea Pigs; In Vitro Techniques; Indomethacin; Lung; Male; Nitrobenzenes; Ovalbumin; Sulfonamides; Thromboxane B2 | 1999 |
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis.
Topics: Animals; Antigens, CD; Arthritis, Rheumatoid; Bone Marrow Cells; Carrier Proteins; Cell Division; Coculture Techniques; Cyclooxygenase Inhibitors; Dinoprostone; Gene Expression Regulation; Humans; Indomethacin; Interleukin-17; Male; Membrane Glycoproteins; Mice; Nitrobenzenes; Osteoclasts; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Sulfonamides; Synovial Fluid | 1999 |
Bone morphogenetic protein-2 enhances osteoclast formation mediated by interleukin-1alpha through upregulation of osteoclast differentiation factor and cyclooxygenase-2.
Topics: Activins; Animals; Bone Development; Bone Marrow Cells; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Carrier Proteins; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gene Expression Regulation, Developmental; Indomethacin; Inhibins; Interleukin-1; Isoenzymes; Membrane Glycoproteins; Mice; Mice, Inbred Strains; Nitrobenzenes; Osteoclasts; Prostaglandin-Endoperoxide Synthases; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; RNA, Messenger; Sulfonamides; Transforming Growth Factor beta; Up-Regulation | 1999 |
Inducible cyclooxygenase may have anti-inflammatory properties.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Inflammation; Isoenzymes; Male; Membrane Proteins; Monocytes; Neutrophils; Nitrobenzenes; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfonamides | 1999 |
A selective cyclo-oxygenase-2 inhibitor, NS-398, may improve portal hypertension without inducing gastric mucosal injury.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ethanol; Gastric Mucosa; Hemodynamics; Hypertension, Portal; Indomethacin; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Portal Pressure; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sulfonamides; Thromboxane B2; Time | 1999 |
Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Arachidonic Acid; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Embryo, Mammalian; Fibroblasts; Ibuprofen; Indomethacin; Isoenzymes; Membrane Proteins; Mice; Mice, Knockout; Nitrobenzenes; Oncogene Proteins, Viral; Piroxicam; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins p21(ras); RNA, Messenger; Simian virus 40; Sulfonamides; Sulindac | 1999 |
PGHS-2 inhibitors, NS-398 and DuP-697, attenuate the inhibition of PGHS-1 by aspirin and indomethacin without altering its activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cattle; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Fibroblasts; Humans; Indomethacin; Isoenzymes; Male; Membrane Proteins; Microsomes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sheep; Sulfonamides; Thiophenes | 1999 |
The effect of selective cyclooxygenase-2 inhibitor on corneal angiogenesis in the rat.
Topics: Administration, Topical; Animals; Cornea; Corneal Neovascularization; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Indomethacin; Isoenzymes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfonamides | 1999 |
Effect of cyclooxygenase-2 inhibition on renal function after renal ablation.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Indomethacin; Isoenzymes; Kidney Function Tests; Male; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Renal Insufficiency; Sulfonamides | 1999 |
Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus.
Topics: Animals; Aspirin; Cell Death; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Synergism; Hippocampus; Indomethacin; Isoenzymes; Kainic Acid; Male; Mice; Neurons; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Seizures; Sulfonamides; Time Factors | 1999 |
Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Endothelium, Vascular; Flavonoids; Humans; Indomethacin; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Neoplasms; Neovascularization, Pathologic; Nitrobenzenes; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Rats; Sulfonamides; Wound Healing | 1999 |
Selective cyclo-oxygenase-2 inhibitors aggravate ischaemia-reperfusion injury in the rat stomach.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Furans; Gastric Mucosa; Indomethacin; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Wistar; Reperfusion Injury; RNA, Messenger; Sulfonamides | 1999 |
Role of prostaglandins generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia-reperfusion-induced gastric lesions.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Gastric Mucosa; Gastrins; Gene Expression Regulation, Enzymologic; Indomethacin; Interleukin-1; Isoenzymes; Lactones; Meloxicam; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Regional Blood Flow; Reperfusion Injury; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stilbenes; Stomach Ulcer; Sulfonamides; Sulfones; Thiazines; Thiazoles; Time Factors | 1999 |
Cyclooxygenase inhibitors suppress angiogenesis and reduce tumor growth in vivo.
Topics: Animals; Apoptosis; Cell Division; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Endothelial Growth Factors; Female; Fibroblast Growth Factor 2; Humans; Indomethacin; Isoenzymes; Lymphokines; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron; Neoplasm Transplantation; Neoplasms, Experimental; Neovascularization, Pathologic; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1999 |
Selective cyclooxygenase-2 inhibitors reduce ureteral contraction in vitro: a better alternative for renal colic?
Topics: Animals; Colic; Cyclooxygenase Inhibitors; Dimethyl Sulfoxide; Humans; In Vitro Techniques; Indomethacin; Kidney Diseases; Muscle Contraction; Nitrobenzenes; Sulfonamides; Swine; Time Factors; Ureter | 2000 |
24R,25-(OH)(2)D(3) mediates its membrane receptor-dependent effects on protein kinase C and alkaline phosphatase via phospholipase A(2) and cyclooxygenase-1 but not cyclooxygenase-2 in growth plate chondrocytes.
Topics: 24,25-Dihydroxyvitamin D 3; Alkaline Phosphatase; Animals; Antioxidants; Cells, Cultured; Chondrocytes; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Growth Plate; Indomethacin; Isoenzymes; Lipoxygenase; Lipoxygenase Inhibitors; Male; Masoprocol; Membrane Proteins; Nitrobenzenes; Phospholipases A; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Steroid Hydroxylases; Sulfonamides; Sulfur Radioisotopes; Thymidine; Transcription, Genetic; Tritium; Umbelliferones; Vitamin D3 24-Hydroxylase | 2000 |
Cyclooxygenase-2 expression in human pancreatic adenocarcinomas.
Topics: Adenocarcinoma; Animals; Cell Line, Transformed; Codon; Cricetinae; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Induction; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Indomethacin; Isoenzymes; Membrane Proteins; Mesocricetus; Neoplasm Proteins; Nitrobenzenes; Pancreas; Pancreatic Neoplasms; Point Mutation; Prostaglandin-Endoperoxide Synthases; Signal Transduction; Sulfonamides; Sulindac | 2000 |
Role of COX-2 inhibition on the formation and healing of gastric ulcers induced by indomethacin in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Indomethacin; Isoenzymes; Ketorolac; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach Ulcer; Sulfonamides; Time Factors; Wound Healing | 1999 |
A comparison of the effects of indomethacin and NS-398 (a selective prostaglandin H synthase-2 inhibitor) on implantation in the rat.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Embryo Implantation; Female; In Vitro Techniques; Indomethacin; Isoenzymes; Nitrobenzenes; Pregnancy; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfonamides; Uterus | 1999 |
Inducible types of cyclooxygenase and nitric oxide synthase in adaptive cytoprotection in rat stomachs.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cytoprotection; Dinoprostone; Enzyme Induction; Gastric Mucosa; Gastrointestinal Contents; Gene Expression Regulation, Enzymologic; Hydrochloric Acid; Indomethacin; Isoenzymes; Male; Membrane Proteins; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfonamides; Taurocholic Acid; Transcription, Genetic | 1999 |
Roles of endogenous prostaglandins and nitric oxide in gastroduodenal ulcerogenic responses induced in rats by hypothermic stress.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Aspirin; Atropine; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Acid; Gastric Mucosa; Hypothermia; Indomethacin; Intestinal Mucosa; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrobenzenes; Peptic Ulcer; Prostaglandins; Rats; Rats, Sprague-Dawley; Stress, Physiological; Sulfonamides; Vagotomy | 1999 |
Effects of selective inhibitors of cyclo-oxygenase-1 (COX-1) and cyclo-oxygenase-2 (COX-2) on the spontaneous myogenic contractions in the upper urinary tract of the guinea-pig and rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Guinea Pigs; Indomethacin; Isoenzymes; Kidney Pelvis; Male; Membrane Proteins; Muscle Contraction; Muscle, Smooth; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Salicylates; Sulfonamides; Ureter | 2000 |
Effective diminution of amniotic prostaglandin production by selective inhibitors of cyclooxygenase type 2.
Topics: Amnion; Blotting, Western; Chorion; Cyclooxygenase Inhibitors; Decidua; Dinoprostone; Electrophoresis, Polyacrylamide Gel; Female; Gene Expression Regulation; Humans; Immunoenzyme Techniques; Indomethacin; Isoenzymes; Labor, Obstetric; Myometrium; Nitrobenzenes; Pregnancy; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Tocolytic Agents | 2000 |
Endogenous prostaglandin formation in the field-stimulated guinea-pig vas deferens: comparison of the inhibitory effects of indomethacin and NS-398.
Topics: Animals; Arachidonic Acid; Cyclooxygenase Inhibitors; Dinoprostone; Electric Stimulation; Guinea Pigs; Indomethacin; Isoenzymes; Male; Muscle Contraction; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfonamides; Vas Deferens | 1999 |
The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive models.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Formaldehyde; Humans; Indomethacin; Isoenzymes; Male; Membrane Proteins; Mice; Nitrobenzenes; Pain Measurement; Piperazines; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiazoles | 2000 |
The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; beta Catenin; Cell Division; Colorectal Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cytoskeletal Proteins; Drug Screening Assays, Antitumor; Humans; Immunoblotting; Indomethacin; Isoenzymes; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Trans-Activators; Tumor Cells, Cultured | 2000 |
Direct and indirect actions of fibroblast growth factor 2 on osteoclastic bone resorption in cultures.
Topics: Acid Phosphatase; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Bone Marrow Cells; Bone Resorption; Calcium; Cells, Cultured; Coculture Techniques; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dentin; Dose-Response Relationship, Drug; Enzyme Induction; Etodolac; Fibroblast Growth Factor 2; Flurbiprofen; Humans; Indomethacin; Isoenzymes; Membrane Proteins; Mice; Nitrobenzenes; Osteoblasts; Osteoclasts; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rabbits; RNA, Messenger; Skull; Sulfonamides; Tartrate-Resistant Acid Phosphatase | 2000 |
Mitochondrial cytochrome c release and caspase-3-like protease activation during indomethacin-induced apoptosis in rat gastric mucosal cells.
Topics: Amino Acid Chloromethyl Ketones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspase 3; Caspases; Cell Line; Cyclooxygenase Inhibitors; Cysteine Proteinase Inhibitors; Cytochrome c Group; Dose-Response Relationship, Drug; Enzyme Activation; Gastric Mucosa; Indomethacin; Mitochondria; Nitrobenzenes; Peptide Hydrolases; Rats; Sulfonamides; Time Factors | 2000 |
Lipopolysaccharide is radioprotective in the mouse intestine through a prostaglandin-mediated mechanism.
Topics: Animals; Blotting, Western; Body Temperature; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Epithelial Cells; Female; Genotype; Indomethacin; Intestine, Small; Isoenzymes; Lipopolysaccharides; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Radiation Injuries, Experimental; Radiation-Protective Agents; Sulfonamides | 2000 |
Cyclooxygenase-2 inhibitors constrict the fetal lamb ductus arteriosus both in vitro and in vivo.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Ductus Arteriosus; Epoprostenol; Female; Hemodynamics; In Vitro Techniques; Indomethacin; Isoenzymes; Nitrobenzenes; Nitroprusside; Oxygen; Pregnancy; Prostaglandin-Endoperoxide Synthases; Pulmonary Artery; Pyrazoles; Sheep; Sulfonamides; Vasoconstriction; Vasodilator Agents | 2000 |
The effects of meloxicam, indomethacin or NS-398 on eicosanoid synthesis by fresh human gastric mucosa.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Culture Techniques; Cyclooxygenase 1; Eicosanoids; Humans; Indomethacin; Intestinal Mucosa; Isoenzymes; Meloxicam; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfonamides; Thiazines; Thiazoles | 2000 |
COX-2 inhibition prevents insulin-dependent diabetes in low-dose streptozotocin-treated mice.
Topics: Animals; Blood Glucose; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dinoprostone; Glycated Hemoglobin; Indomethacin; Isoenzymes; Male; Mice; Mice, Inbred BALB C; Nitrobenzenes; Pancreas; Prostaglandin-Endoperoxide Synthases; Streptozocin; Sulfonamides; Time Factors | 2000 |
Phorbol ester stimulates cyclooxygenase-2 expression and prostanoid production in cardiac myocytes.
Topics: Animals; Animals, Newborn; Cell Division; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Gene Expression Regulation, Enzymologic; Indomethacin; Interleukin-1; Isoenzymes; Leucine; Mitogen-Activated Protein Kinases; Myocardium; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetradecanoylphorbol Acetate | 2000 |
Cyclo-oxygenase-2 inhibitors suppress epithelial cell kinetics and delay gastric wound healing in rats.
Topics: Animals; Cell Division; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Epithelial Cells; Gastric Mucosa; Indomethacin; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Stomach; Sulfonamides; Wound Healing | 2000 |
Growth differentiation factor-9 stimulates progesterone synthesis in granulosa cells via a prostaglandin E2/EP2 receptor pathway.
Topics: Alprostadil; Animals; Bone Morphogenetic Protein 15; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Female; Granulosa Cells; Growth Differentiation Factor 9; Growth Substances; Indomethacin; Intercellular Signaling Peptides and Proteins; Isoenzymes; Kinetics; Male; Mice; Mice, Inbred ICR; Models, Biological; Nitrobenzenes; Progesterone; Prostaglandin-Endoperoxide Synthases; Prostaglandins E, Synthetic; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Transcription, Genetic | 2000 |
The role of cyclooxygenases in endotoxin- and interleukin-1-induced hypophagia.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Drinking; Endotoxins; Feeding and Eating Disorders; Indomethacin; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Lipopolysaccharides; Male; Mice; Milk; Nitrobenzenes; Piroxicam; Prostaglandin-Endoperoxide Synthases; Sialoglycoproteins; Sulfonamides | 2000 |
Effect of cyclooxygenase inhibitors in the adhesion of tumor cells to endothelial cells.
Topics: Animals; Cell Adhesion; Cyclooxygenase Inhibitors; Endothelium; Indomethacin; Integrins; Lymphoma; Mice; Nitrobenzenes; Sulfonamides; Sulindac; Tumor Cells, Cultured; Vascular Cell Adhesion Molecule-1 | 2000 |
Role of cyclooxygenase-2 in Helicobacter pylori- induced gastritis in Mongolian gerbils.
Topics: Animals; Chemokines; Chemotactic Factors; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Mucosa; Gastritis; Gastrointestinal Hemorrhage; Gerbillinae; Growth Inhibitors; Growth Substances; Helicobacter Infections; Helicobacter pylori; Indomethacin; Interferon-gamma; Interleukin-10; Isoenzymes; Male; Neutrophils; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 2000 |
Nonsteroidal anti-inflammatory drug-induced acute gastric injury in Helicobacter pylori gastritis in Mongolian gerbils.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Dinoprostone; Gastric Mucosa; Gastritis; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Indomethacin; Isoenzymes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 2000 |
Cyclooxygenase-2-mediated angiogenesis in carrageenin-induced granulation tissue in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Growth Factors; Granulation Tissue; Indomethacin; Inflammation; Isoenzymes; Leukocytes; Lymphokines; Male; Membrane Proteins; Neovascularization, Physiologic; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfonamides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Endotoxin-induced myocardial tumor necrosis factor-alpha synthesis depresses contractility of isolated rat hearts: evidence for a role of sphingosine and cyclooxygenase-2-derived thromboxane production.
Topics: Animals; Capillary Permeability; Creatine Kinase; Cyclooxygenase 2; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Epoprostenol; Ethanolamines; Gene Expression Regulation; Heart; Immune Sera; In Vitro Techniques; Indomethacin; Isoenzymes; L-Lactate Dehydrogenase; Lipopolysaccharides; Myocardial Contraction; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrobenzenes; Oleic Acids; Phenylacetates; Prostaglandin-Endoperoxide Synthases; Rats; RNA, Messenger; Sphingosine; Sulfonamides; Thromboxane A2; Thromboxanes; Tumor Necrosis Factor-alpha | 2000 |
Intrathecal cyclooxygenase inhibitor administration attenuates morphine antinociceptive tolerance in rats.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Indomethacin; Injections, Spinal; Male; Morphine; Nitrobenzenes; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Sulfonamides | 2000 |
Upregulation of angiotensin-converting enzyme by vascular endothelial growth factor.
Topics: Benzoquinones; Cell Division; Cells, Cultured; Cyclic GMP; Cyclooxygenase Inhibitors; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Gene Expression Regulation, Enzymologic; Humans; Indoles; Indomethacin; Lactams, Macrocyclic; Lymphokines; Maleimides; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrobenzenes; Peptidyl-Dipeptidase A; Phosphodiesterase Inhibitors; Protein Kinase C; Protein-Tyrosine Kinases; Purinones; Quinones; Rifabutin; RNA, Messenger; Signal Transduction; Sulfonamides; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Effects of indomethacin, NS-398 (a selective prostaglandin H synthase-2 inhibitor) and protein synthesis inhibitors on prostaglandin production by the guinea-pig placenta.
Topics: Animals; Cell Culture Techniques; Cyclooxygenase Inhibitors; Female; Guinea Pigs; Indomethacin; Isoenzymes; Nitrobenzenes; Placenta; Pregnancy; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Synthesis Inhibitors; Sulfonamides | 2001 |
Prostaglandin H synthase-2 inhibitors interfere with prostaglandin H synthase-1 inhibition by nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Cattle; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Ibuprofen; Indomethacin; Isoenzymes; Male; Microsomes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sulfonamides; Thiophenes | 2001 |
Involvement of cyclooxygenase (COX)-2 products in acceleration of ulcer healing by gastrin and hepatocyte growth factor.
Topics: Animals; Antibodies; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Gastric Mucosa; Gastrins; Hepatocyte Growth Factor; Indomethacin; Isoenzymes; Lactones; Male; Membrane Proteins; Nitrobenzenes; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Sulfones | 2000 |
Agonist-specific regulation of monocyte chemoattractant protein-1 expression by cyclooxygenase metabolites in hepatic stellate cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Cells, Cultured; Chemokine CCL2; Cyclic AMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gene Expression; Humans; Ibuprofen; Indomethacin; Interleukin-1; Isoenzymes; Liver; Membrane Proteins; NF-kappa B; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2001 |
Effects of COX-1 and COX-2 inhibitors on eicosanoid biosynthesis and the release of substance P from the guinea-pig isolated perfused lung.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Bradykinin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cysteine; Eicosanoids; Female; Guinea Pigs; Indomethacin; Inflammation Mediators; Isoenzymes; Leukotriene C4; Leukotrienes; Lung; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Substance P; Sulfonamides | 2001 |
Differential effects of ethanol on the expression of cyclo-oxygenase in cultured cortical astrocytes and neurons.
Topics: Animals; Animals, Newborn; Arachidonic Acid; Astrocytes; Cells, Cultured; Cerebral Cortex; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Ethanol; Indomethacin; Isoenzymes; Kinetics; Membrane Proteins; Neurons; Nitrobenzenes; Phospholipases A; Prostaglandin-Endoperoxide Synthases; Rats; Sulfonamides | 2001 |
Both cyclooxygenase-1 and cyclooxygenase-2 mediate osteoblast response to titanium surface roughness.
Topics: Alkaline Phosphatase; Biocompatible Materials; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Indomethacin; Isoenzymes; Materials Testing; Membrane Proteins; Nitrobenzenes; Osteoblasts; Osteocalcin; Phenotype; Prostaglandin-Endoperoxide Synthases; Resveratrol; Stilbenes; Sulfonamides; Surface Properties; Titanium; Transforming Growth Factor beta | 2001 |
Stimulation of cyclooxygenase-2-activity by nitric oxide-derived species in rat chondrocyte: lack of contribution to loss of cartilage anabolism.
Topics: Animals; Cartilage; Chondrocytes; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Indomethacin; Interleukin-1; Isoenzymes; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitrobenzenes; omega-N-Methylarginine; Prostaglandin-Endoperoxide Synthases; Proteoglycans; Rats; Rats, Wistar; Sulfonamides; Thiourea | 2001 |
Effect of hypoxia, oxidative stress and lipopolysaccharides on the release of prostaglandins and cytokines from human term placental explants.
Topics: Adult; Cell Hypoxia; Chorionic Villi; Culture Techniques; Cyclooxygenase Inhibitors; Cytokines; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hypoxia; Indomethacin; Lipopolysaccharides; Nitrobenzenes; Oxidative Stress; Oxygen; Pregnancy; Prostaglandins; Sulfonamides; Xanthine; Xanthine Oxidase | 2001 |
Involvement of cyclooxygenase-derived prostaglandin E2 and nitric oxide in the protection of rat pancreas afforded by low dose of lipopolysaccharide.
Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ceruletide; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Indomethacin; Isoenzymes; Lactones; Lipopolysaccharides; Male; Membrane Proteins; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nitrobenzenes; Organ Size; Pancreas; Pancreatitis; Penicillamine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Resveratrol; S-Nitroso-N-Acetylpenicillamine; Stilbenes; Sulfonamides; Sulfones | 2001 |
Involvement of cyclooxygenase-2 in serum-induced prostaglandin production by human oral gingival epithelial cells.
Topics: Analysis of Variance; Blood; Blotting, Western; Cells, Cultured; Culture Media; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Epithelial Cells; Gene Expression; Gingiva; Humans; Indomethacin; Inflammation Mediators; Interleukin-1; Isoenzymes; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Statistics as Topic; Sulfonamides; Time Factors; Tumor Necrosis Factor-alpha | 2001 |
Tumor necrosis factor-alpha induces cyclooxygenase-2 expression and prostaglandin release in brain microvessel endothelial cells.
Topics: Animals; Blood-Brain Barrier; Blotting, Western; Brain; Cattle; Cell Membrane Permeability; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytoskeleton; Dinoprost; Dinoprostone; Endothelium, Vascular; Indomethacin; Isoenzymes; Microcirculation; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfonamides; Tumor Necrosis Factor-alpha | 2001 |
Adaptive gastric cytoprotection is mediated by prostaglandin EP1 receptors: a study using rats and knockout mice.
Topics: Adaptation, Physiological; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cytoprotection; Dinoprostone; Dose-Response Relationship, Drug; Ethanol; Gastric Mucosa; Hydrochloric Acid; Indomethacin; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Stomach Ulcer; Sulfonamides; Taurocholic Acid | 2001 |
Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Mucosa; Gastrins; Indomethacin; Interleukin-1; Isoenzymes; Lactones; Male; Meloxicam; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Rats; Rats, Wistar; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stilbenes; Stomach Ulcer; Sulfonamides; Sulfones; Thiazines; Thiazoles; Tumor Necrosis Factor-alpha | 2001 |
COX-2 expression and cell cycle progression in human fibroblasts.
Topics: Apoptosis; Aspirin; Cell Cycle; Cells, Cultured; Culture Media, Serum-Free; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Fibroblasts; Humans; Indomethacin; Interleukin-1; Isoenzymes; Membrane Proteins; Nitrobenzenes; Platelet-Derived Growth Factor; Prostaglandin-Endoperoxide Synthases; Protein Isoforms; Sulfonamides | 2001 |
Dendritic cells issued in vitro from bone marrow produce PGE(2) that contributes to the immunomodulation induced by antigen-presenting cells.
Topics: Adjuvants, Immunologic; Animals; Antigen-Presenting Cells; Bone Marrow Cells; Cell Lineage; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dendritic Cells; Dinoprostone; Female; Indomethacin; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred BALB C; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 2001 |
Effects of nonsteroidal anti-inflammatory drugs on Helicobacter pylori-infected gastric mucosae of mice: apoptosis, cell proliferation, and inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Division; Chronic Disease; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Epithelial Cells; Female; Gastric Mucosa; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Indomethacin; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred C57BL; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 2001 |
Modulation of haem oxygenase-1 expression by nitric oxide and leukotrienes in zymosan-activated macrophages.
Topics: Amidines; Animals; Benzylamines; Cell Line; Chick Embryo; Cyclooxygenase 2; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Eicosanoids; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hydroxyurea; Indomethacin; Isoenzymes; Leukotriene B4; Leukotriene C4; Leukotrienes; Macrophage Activation; Macrophages; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein Binding; Pyrans; Quinolones; Sulfonamides; Time Factors; Transcription Factor AP-1; Zymosan | 2001 |
Effects of 1alpha,25-(OH)(2)D(3) on rat growth zone chondrocytes are mediated via cyclooxygenase-1 and phospholipase A(2).
Topics: Alkaline Phosphatase; Animals; Arachidonic Acid; Blotting, Northern; Calcitriol; Cells, Cultured; Chondrocytes; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Growth Plate; Indomethacin; Isoenzymes; Lipoxygenase; Lipoxygenase Inhibitors; Masoprocol; Membrane Proteins; Nitrobenzenes; Phospholipases A; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Proteoglycans; Rats; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; Stilbenes; Sulfonamides; Thymidine; Umbelliferones | 2001 |
Cyclooxygenase inhibitors retard murine mammary tumor progression by reducing tumor cell migration, invasiveness and angiogenesis.
Topics: Animals; Cell Division; Cell Movement; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Female; Indomethacin; Isoenzymes; Mammary Neoplasms, Experimental; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Membrane Proteins; Mice; Mice, Inbred C3H; Neovascularization, Pathologic; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides | 2001 |
Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer.
Topics: Animals; Breast Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Female; Indomethacin; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasm Transplantation; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Tumor Cells, Cultured | 2001 |
PGE2 suppresses intestinal T cell function in thermal injury: a cause of enhanced bacterial translocation.
Topics: Animals; Bacterial Translocation; Burns; Cyclooxygenase Inhibitors; Dinoprostone; Indomethacin; Intestines; Lymph Nodes; Male; Nitrobenzenes; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Rats; Rats, Sprague-Dawley; Sulfonamides; T-Lymphocytes | 2001 |
Nitric oxide (NO) modulation of PAF-induced cardiopulmonary action: interaction between NO synthase and cyclo-oxygenase-2 pathways.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Airway Resistance; Animals; Arginine; Blood Pressure; Cardiac Output; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Heart; Heart Rate; Histamine; Indomethacin; Isoenzymes; Lung; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitrobenzenes; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Pulmonary Ventilation; Serotonin; Signal Transduction; Sulfonamides | 2001 |
Human airway smooth muscle cells secrete vascular endothelial growth factor: up-regulation by bradykinin via a protein kinase C and prostanoid-dependent mechanism.
Topics: Adult; Arachidonic Acid; Bradykinin; Bradykinin Receptor Antagonists; Cell Survival; Cells, Cultured; Cyclic AMP; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Growth Factors; Enzyme Inhibitors; Female; Gene Expression; Humans; Indomethacin; Lymphokines; Male; Middle Aged; Muscle, Smooth, Vascular; Naphthalenes; Nitrobenzenes; Prostaglandins; Protein Isoforms; Protein Kinase C; Receptor, Bradykinin B2; Receptors, Bradykinin; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sulfonamides; Time Factors; Trachea; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Role of cyclopentenone prostaglandins in rat carrageenin pleurisy.
Topics: Active Transport, Cell Nucleus; Animals; Carrageenan; Cyclooxygenase Inhibitors; Disease Models, Animal; DNA-Binding Proteins; Drug Combinations; Exudates and Transudates; Heat Shock Transcription Factors; Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Humans; Indomethacin; Male; NF-kappa B; NF-kappa B p50 Subunit; Nitrobenzenes; Pleura; Pleurisy; Prostaglandin D2; Prostaglandins; Rats; Rats, Wistar; Sulfonamides; Transcription Factor RelA; Transcription Factors | 2001 |
Cyclooxygenase-2 inhibitor NS398 preserves neuronal function after hypoxia/ischemia in piglets.
Topics: Animals; Animals, Newborn; Blood Pressure; Cerebrovascular Circulation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Excitatory Amino Acid Agonists; Female; Hypoxia-Ischemia, Brain; Indomethacin; Isoenzymes; Male; N-Methylaspartate; Neurons; Nitrobenzenes; Pia Mater; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Swine; Thromboxane B2; Vasodilation | 2001 |
Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells.
Topics: Acetylcysteine; beta Catenin; Blotting, Western; Colorectal Neoplasms; Cyclin D1; Cytoskeletal Proteins; Desmoplakins; DNA; Dose-Response Relationship, Drug; Down-Regulation; Electrophoretic Mobility Shift Assay; gamma Catenin; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Interleukin-2; Isoenzymes; Nitrobenzenes; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase C beta; Proto-Oncogene Proteins c-myc; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Sulfonamides; Trans-Activators; Transcription Factors; Tumor Cells, Cultured | 2002 |
Cyclooxygenase-2 overexpression inhibits platelet-derived growth factor-induced mesangial cell proliferation through induction of the tumor suppressor gene p53 and the cyclin-dependent kinase inhibitors p21waf-1/cip-1 and p27kip-1.
Topics: Animals; Blotting, Western; Cell Cycle Proteins; Cell Division; Cell Line; Cell Separation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Desmin; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Genes, p53; Glomerular Mesangium; Indomethacin; Isoenzymes; Male; Nitrobenzenes; Plasmids; Platelet-Derived Growth Factor; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors; Transcriptional Activation; Transfection; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2002 |
MAPK (ERK2) kinase--a key target for NSAIDs-induced inhibition of gastric cancer cell proliferation and growth.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Division; Cyclooxygenase Inhibitors; DNA; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; In Situ Nick-End Labeling; Indomethacin; Mitogen-Activated Protein Kinase 1; Nitrobenzenes; ras Proteins; Stomach Neoplasms; Sulfonamides; Thymidine; Tumor Cells, Cultured | 2001 |
Nonsteroidal anti-inflammatory drugs inhibit re-epithelialization of wounded gastric monolayers by interfering with actin, Src, FAK, and tensin signaling.
Topics: Actins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Movement; Cyclooxygenase Inhibitors; Cytoskeleton; Dose-Response Relationship, Drug; Drug Interactions; Epidermal Growth Factor; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gastric Mucosa; Indomethacin; Microfilament Proteins; Nitrobenzenes; Protein-Tyrosine Kinases; Rats; Signal Transduction; src-Family Kinases; Sulfonamides; Tensins; Wound Healing | 2001 |
von Hippel Lindau tumor suppressor and HIF-1alpha: new targets of NSAIDs inhibition of hypoxia-induced angiogenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Hypoxia; Cell Line; Endothelial Growth Factors; Endothelium, Vascular; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indomethacin; Ligases; Lymphokines; Neovascularization, Pathologic; Nitrobenzenes; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; RNA, Messenger; Sulfonamides; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin; Ubiquitin-Protein Ligases; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factors; Von Hippel-Lindau Tumor Suppressor Protein | 2002 |
Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Computer Graphics; Computer Simulation; Crystallography, X-Ray; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Energy Transfer; Flurbiprofen; Humans; Indomethacin; Isoenzymes; Ketoprofen; Meclofenamic Acid; Mefenamic Acid; Membrane Proteins; Models, Molecular; Naproxen; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides | 2002 |
The cyclooxygenase system participates in functional mdr1b overexpression in primary rat hepatocyte cultures.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Epidermal Growth Factor; Gene Expression Regulation; Hepatocytes; Indomethacin; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; RNA, Messenger; Sulfonamides; Transcriptional Activation | 2002 |
High NaCl intake decreases both flow-induced dilation and pressure-induced myogenic tone in resistance arteries from normotensive rats: involvement of cyclooxygenase-2.
Topics: Animals; Arginine; Blood Pressure; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Endothelium, Vascular; Indomethacin; Isoenzymes; Mesenteric Arteries; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred WKY; Regional Blood Flow; Sodium Chloride, Dietary; Sulfonamides; Vasodilation | 2001 |
Irritant-induced cyclooxygenase-2 is involved in the defense mechanism of the gastric mucosa in mice.
Topics: Animals; Central Nervous System Depressants; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytoprotection; Ethanol; Gastric Mucosa; Immunohistochemistry; Indomethacin; Irritants; Isoenzymes; Male; Membrane Proteins; Mice; Models, Animal; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Stomach Ulcer; Sulfonamides | 2002 |
Dihydrotestosterone (DHT) modulates the ability of NSAIDs to induce apoptosis of prostate cancer cells.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dihydrotestosterone; Humans; Indomethacin; Isoenzymes; Male; Membrane Proteins; Microscopy, Electron; Microscopy, Electron, Scanning; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostatic Neoplasms; Sulfonamides; Tumor Cells, Cultured | 2002 |
Recovery of ischaemic injured porcine ileum: evidence for a contributory role of COX-1 and COX-2.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Eicosanoids; Female; Ileum; Indomethacin; Intestinal Mucosa; Ischemia; Isoenzymes; Male; Nitrobenzenes; Permeability; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Swine | 2002 |
Prostaglandin E2 down-regulates viable Bacille Calmette-Guérin-induced macrophage cytotoxicity against murine bladder cancer cell MBT-2 in vitro.
Topics: Animals; Antibodies; BCG Vaccine; Cells, Cultured; Cyclooxygenase Inhibitors; Cytokines; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic; Dinoprostone; Down-Regulation; Female; Indomethacin; Interferon-gamma; Macrophages; Macrophages, Peritoneal; Mice; Mice, Inbred C3H; Nitrobenzenes; Sulfonamides; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Urinary Bladder Neoplasms | 2002 |
Effects of Ginkgetin from Ginkgo biloba Leaves on cyclooxygenases and in vivo skin inflammation.
Topics: Animals; Biflavonoids; Blotting, Western; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Flavonoids; Ginkgo biloba; Indomethacin; Inflammation; Isoenzymes; Macrophages; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Monocytes; Nitrobenzenes; Phospholipases; Plant Extracts; Plant Leaves; Prostaglandin-Endoperoxide Synthases; Skin; Sulfonamides | 2002 |
Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Capillary Leak Syndrome; Capillary Permeability; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cysteine; Diterpenes; Eicosanoids; Enzyme Induction; Ginkgolides; Histamine Release; Indoles; Indomethacin; Isoenzymes; Lactones; Leukotriene C4; Leukotrienes; Lipoxygenase Inhibitors; Macrophages, Peritoneal; Male; Mast Cells; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Nitrobenzenes; Peritonitis; Phospholipid Ethers; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Quinolines; Sulfonamides; Thioglycolates; Zymosan | 2002 |
Suppression of prostaglandin synthesis with NS-398 has different effects on endocortical and periosteal bone formation induced by mechanical loading.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Indomethacin; Isoenzymes; Nitrobenzenes; Physical Stimulation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Sulfonamides; Tibia; Ulna | 2002 |
Ischemia/reperfusion-induced increase in the hepatic level of prostacyclin is mainly mediated by activation of capsaicin-sensitive sensory neurons in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Epoprostenol; Guanidines; Indomethacin; Isoenzymes; Liver; Liver Circulation; Male; Membrane Proteins; Miotics; Neurons, Afferent; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrobenzenes; Peptide Fragments; Peroxidase; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Reperfusion Injury; Specific Pathogen-Free Organisms; Sulfonamides; Transaminases; Tumor Necrosis Factor-alpha | 2002 |
The COX-2 inhibitor NS-398 causes T-cell developmental disruptions independent of COX-2 enzyme inhibition.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Immunologic Deficiency Syndromes; Indomethacin; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Nitrobenzenes; Organ Culture Techniques; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Sulfonamides; T-Lymphocytes; Thiophenes; Thymus Gland | 2001 |
Dopamine D(2) receptor-induced COX-2-mediated production of prostaglandin E(2) in D(2)-transfected Chinese hamster ovary cells without simultaneous administration of a Ca(2+)-mobilizing agent.
Topics: Animals; Arachidonic Acids; Calcium; Calcium Channel Blockers; CHO Cells; Cricetinae; Cyclooxygenase 2; Dinoprostone; Dopamine; Dopamine Antagonists; Drug Interactions; Enzyme Inhibitors; Gallic Acid; Indomethacin; Isoenzymes; Naphthalenes; Nitrobenzenes; Phosphatidylcholines; Prostaglandin-Endoperoxide Synthases; Pyrones; Quinacrine; Receptors, Dopamine D2; Salicylamides; Salicylates; Sulfonamides; Tetradecanoylphorbol Acetate; Transfection | 2002 |
NSAID inhibition of RGM1 gastric monolayer wound re-epithelialization: comparison of selective Cox-2 versus non-selective Cox inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Epithelial Cells; Fibroblast Growth Factor 2; Gastric Mucosa; Indomethacin; Isoenzymes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Sulfonamides | 2002 |
Bradykinin increases IL-8 generation in airway epithelial cells via COX-2-derived prostanoids.
Topics: Arachidonic Acid; Bradykinin; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cystic Fibrosis; Dinoprostone; Epithelial Cells; Humans; Indomethacin; Interleukin-8; Isoenzymes; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfonamides; Trachea | 2002 |
Hypertension alters the participation of contractile prostanoids and superoxide anions in lipopolysaccharide effects on small mesenteric arteries.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 2; Dexamethasone; Dose-Response Relationship, Drug; Drug Combinations; Fatty Acids, Unsaturated; Hydrazines; Hypertension; In Vitro Techniques; Indomethacin; Isoenzymes; Lipopolysaccharides; Male; Mesenteric Arteries; Mice; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrobenzenes; Norepinephrine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Thromboxane; Sulfonamides; Superoxide Dismutase; Thromboxane A2 | 2002 |
The skin fungus-induced Th1- and Th2-related cytokine, chemokine and prostaglandin E2 production in peripheral blood mononuclear cells from patients with atopic dermatitis and psoriasis vulgaris.
Topics: Adult; Antigens, Fungal; Candida albicans; Case-Control Studies; Chemokine CCL22; Chemokine CXCL10; Chemokines, CC; Chemokines, CXC; Cyclooxygenase Inhibitors; Dermatitis, Atopic; Dermatomycoses; Dinoprostone; Female; Humans; Indomethacin; Interferon-gamma; Interleukin-4; Leukocytes, Mononuclear; Malassezia; Male; Nitrobenzenes; Psoriasis; Pyrazoles; Sulfonamides; Th1 Cells; Th2 Cells; Trichophyton | 2002 |
COX-1 and COX-2 contributions to basal and IL-1 beta-stimulated prostanoid synthesis in human neonatal cerebral microvascular endothelial cells.
Topics: Animals; Cells, Cultured; Cerebrovascular Circulation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Endothelium, Vascular; Fetal Death; Fetus; Humans; Indomethacin; Infant, Newborn; Infant, Premature; Interleukin-1; Isoenzymes; Membrane Proteins; Microcirculation; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfonamides; Tyrphostins | 2002 |
Relationship between NOC/oFQ, dynorphin, and COX-2 activation in impaired NMDA cerebrovasodilation after brain injury.
Topics: Animals; Animals, Newborn; Brain Injuries; Cyclooxygenase 2; Dynorphins; Enzyme Activation; Female; Glutamic Acid; Indomethacin; Isoenzymes; Male; N-Methylaspartate; Naltrexone; Nitrobenzenes; Nociceptin; Opioid Peptides; Pia Mater; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Superoxides; Swine; Vasodilation | 2002 |
Inhibition of renin-angiotensin system ameliorates endothelial dysfunction associated with aging in rats.
Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 2; Drug Administration Schedule; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Imidazoles; Indomethacin; Isoenzymes; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrobenzenes; Olmesartan Medoxomil; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred WKY; Renin-Angiotensin System; Sulfonamides; Superoxides; Tetrazoles; Thiazepines | 2002 |
Effect of constitutive- and inducible-cyclooxygenase in the carbachol-induced pituitary-adrenocortical response during social stress.
Topics: Adrenal Cortex; Animals; Carbachol; Cholinergic Agonists; Crowding; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Hypothalamo-Hypophyseal System; Indomethacin; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Piroxicam; Pituitary-Adrenal System; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Receptors, Muscarinic; Stress, Psychological; Sulfonamides | 2002 |
On the interaction of specific prostaglandin H synthase-2 inhibitors with prostaglandin H synthase-1.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Binding, Competitive; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ibuprofen; In Vitro Techniques; Indomethacin; Isoenzymes; Male; Microsomes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sheep; Sulfonamides | 2002 |
Wound healing involves induction of cyclooxygenase-2 expression in rat skin.
Topics: Animals; Blotting, Western; Capillaries; Cyclooxygenase 2; Dinoprostone; Endothelial Growth Factors; Enzyme Induction; Fibroblast Growth Factor 2; Immunohistochemistry; In Situ Hybridization; Indomethacin; Intercellular Signaling Peptides and Proteins; Isoenzymes; Lymphokines; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Skin; Sulfonamides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wound Healing | 2002 |
Downregulation of nNOS and synthesis of PGs associated with endotoxin-induced delay in gastric emptying.
Topics: Animals; Arachidonic Acid; Cyclooxygenase Inhibitors; Endotoxins; Enzyme Inhibitors; Food; Gastric Emptying; Indazoles; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitrobenzenes; Phospholipases A; Prostaglandins; Pyloric Antrum; Quinacrine; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides | 2002 |
Requirement of cyclooxygenase-2 expression and prostaglandins for human prostate cancer cell invasion.
Topics: 6-Ketoprostaglandin F1 alpha; Adenocarcinoma; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Humans; Indomethacin; Isoenzymes; Male; Membrane Proteins; Neoplasm Invasiveness; Nitrobenzenes; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Prostatic Neoplasms; Sulfonamides; Tumor Cells, Cultured | 2002 |
Study of the mechanisms involved in the bradykinin-induced contraction of the pig iris sphincter muscle in vitro.
Topics: Animals; Atropine; Bradykinin; Bradykinin Receptor Antagonists; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanethidine; Ibuprofen; Imidazoles; In Vitro Techniques; Indomethacin; Iris; Kallidin; Muscle Contraction; Muscle, Smooth; Nitrobenzenes; Propionates; Quinolines; Salicylates; Sulfonamides; Swine; Tetrodotoxin; Thromboxane-A Synthase | 2003 |
Late administration of COX-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chloroform; Cyclooxygenase Inhibitors; Cytoprotection; Disease Models, Animal; Hepatocytes; Indomethacin; Male; Necrosis; Nitrobenzenes; Rats; Rats, Sprague-Dawley; Sulfonamides | 2003 |
Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors.
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Cyclooxygenase 2; Dexamethasone; Dinoprostone; Flurbiprofen; Humans; Indomethacin; Isoenzymes; Lung; Membrane Proteins; Muscle, Smooth; NF-kappa B; Nitrobenzenes; Promoter Regions, Genetic; Prostaglandin Antagonists; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Transport; Receptors, Cytoplasmic and Nuclear; Response Elements; Sulfonamides; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation | 2003 |
Cyclooxygenase-2 and inducible nitric oxide synthase in omental arteries harvested from patients with severe liver diseases: immuno-localization and influence on vascular tone.
Topics: Adult; Arteries; Blotting, Western; Carcinoma, Hepatocellular; Case-Control Studies; Cyclooxygenase 2; Dilatation, Pathologic; Female; Hepatitis, Viral, Human; Humans; Immunohistochemistry; Indomethacin; Isoenzymes; Liver Failure; Liver Neoplasms; Liver Transplantation; Male; Membrane Proteins; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrobenzenes; Norepinephrine; Omentum; Prostaglandin-Endoperoxide Synthases; Severity of Illness Index; Sulfonamides; Up-Regulation | 2003 |
The stable analog carbocyclic TXA2 but not platelet-released TXA2 induces osteoclast-like cell formation.
Topics: Acid Phosphatase; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Bone Marrow Cells; Bridged Bicyclo Compounds, Heterocyclic; Carrier Proteins; Cell Nucleus; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydrazines; Indomethacin; Membrane Glycoproteins; Mice; Nitrobenzenes; Osteoclasts; Prostaglandin-Endoperoxide Synthases; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Stromal Cells; Sulfonamides; Tartrates; Thromboxane A2 | 2003 |
Cyclooxygenase-2 mediates interleukin-6 upregulation by vomitoxin (deoxynivalenol) in vitro and in vivo.
Topics: Animals; Crosses, Genetic; Cyclooxygenase 2; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Enzymologic; Indomethacin; Interleukin-6; Isoenzymes; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Nitrobenzenes; Peyer's Patches; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spleen; Sulfonamides; Trichothecenes; Up-Regulation | 2003 |
Cyclooxygenase (COX) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxygenase independent pathways.
Topics: Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytochrome c Group; Dinoprostone; Flavoproteins; Humans; Immunoenzyme Techniques; Indomethacin; Isoenzymes; Lung Neoplasms; Membrane Proteins; Microscopy, Fluorescence; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Proteins; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sulfonamides; Tumor Cells, Cultured | 2003 |
Immunomodulatory effects of the tobacco-specific carcinogen, NNK, on alveolar macrophages.
Topics: Animals; Antibodies, Monoclonal; Carcinogens; Cell Line; Chemokine CCL3; Chemokine CCL4; Cyclooxygenase Inhibitors; Depression, Chemical; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Interleukin-10; Interleukin-12; Lipopolysaccharides; Macrophage Inflammatory Proteins; Macrophages, Alveolar; Nitric Oxide; Nitrobenzenes; Nitrosamines; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Smoking; Sulfonamides; Time Factors; Tumor Necrosis Factor-alpha | 2003 |
Implication of cyclooxygenase-2 on enhanced proliferation of neural progenitor cells in the adult mouse hippocampus after ischemia.
Topics: Animals; Astrocytes; Brain Ischemia; Cell Differentiation; Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Hippocampus; Immunohistochemistry; Indomethacin; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Stem Cells; Sulfonamides | 2003 |
Cyclooxygenase-2 mediates mucin secretion from epithelial cells of lipopolysaccharide-treated canine gallbladder.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cells, Cultured; Cholelithiasis; Cyclic AMP; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dogs; Epithelial Cells; Gallbladder; In Vitro Techniques; Indomethacin; Isoenzymes; Lipopolysaccharides; Mucins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 2003 |
Cyclooxygenase-2-dependent superoxide generation contributes to age-dependent impairment of G protein-mediated cerebrovasodilation.
Topics: Aging; Animals; Animals, Newborn; Arteries; Blood Chemical Analysis; Brain Injuries; Catalase; Cerebrovascular Circulation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Free Radical Scavengers; GTP-Binding Proteins; Indomethacin; Intercellular Signaling Peptides and Proteins; Isoenzymes; Male; Nitrobenzenes; Peptides; Pertussis Toxin; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Superoxide Dismutase; Superoxides; Swine; Vasodilation; Wasp Venoms | 2003 |
Interaction of hepatocyte growth factor and non-steroidal anti-inflammatory drugs during gastric epithelial wound healing.
Topics: Actins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Culture Techniques; Cell Division; Cell Survival; Gastric Mucosa; Growth Substances; Hepatocyte Growth Factor; Indomethacin; Models, Animal; Nitrobenzenes; Rats; Stomach Ulcer; Sulfonamides; Wound Healing | 2003 |
The protective effect of rebamipide on paracellular permeability of rat gastric epithelial cells.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inhibitors; Dinoprostone; Epithelial Cells; Gastric Mucosa; Indomethacin; Nitrobenzenes; Permeability; Quinolones; Rats; Sulfonamides | 2003 |
COX-2 induction during murine gammaherpesvirus 68 infection leads to enhancement of viral gene expression.
Topics: Animals; Cell Line; Cricetinae; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Gammaherpesvirinae; Gene Expression Regulation, Viral; Genes, Viral; Herpesviridae Infections; Indomethacin; Isoenzymes; Mice; Nitrobenzenes; Oligonucleotide Array Sequence Analysis; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 2003 |
Prostaglandin levels in seminal plasma and sperm extracts of the domestic turkey, and the effects of cyclooxygenase inhibitors on sperm mobility.
Topics: Alprostadil; Animals; Aspirin; Cell Membrane; Cryopreservation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Isoenzymes; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Resveratrol; Semen; Semen Preservation; Sperm Motility; Spermatozoa; Stilbenes; Sulfonamides; Tolmetin; Turkeys | 2003 |
Protease-activated receptor-2-mediated contraction of urinary bladder is enhanced in cyclophosphamide-treated rats.
Topics: Animals; Cyclooxygenase 2; Cyclophosphamide; Cystitis; Dinoprostone; In Vitro Techniques; Indomethacin; Isoenzymes; Male; Mucous Membrane; Muscle Contraction; Muscle, Smooth; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Receptor, PAR-2; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Trypsin; Urinary Bladder | 2004 |
Influence of cyclooxygenase inhibitors on the central histaminergic stimulations of hypothalamic - pituitary - adrenal axis.
Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Administration Schedule; Histamine; Histamine Agonists; Hypothalamo-Hypophyseal System; Indomethacin; Injections, Intraperitoneal; Injections, Intraventricular; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Piroxicam; Pituitary-Adrenal System; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfonamides; Thiazoles | 2003 |
Role of polymorphonuclear leukocytes, nitric oxide synthase, and cyclooxygenase in vascular permeability changes induced by C5a agonist peptides.
Topics: Animals; Antibodies, Monoclonal; Binding, Competitive; Capillary Permeability; Cell Line, Tumor; CHO Cells; Complement C5a; Cricetinae; Cricetulus; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female; Granulocytes; Guanidines; Humans; Indomethacin; Mice; Mice, Nude; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitrobenzenes; Oligopeptides; P-Selectin; Prostaglandin-Endoperoxide Synthases; Protein Binding; Receptor, Anaphylatoxin C5a; Sulfonamides; Xenograft Model Antitumor Assays | 2004 |
NSAIDs activate PTEN and other phosphatases in human colon cancer cells: novel mechanism for chemopreventive action of NSAIDs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Caco-2 Cells; Chemoprevention; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Nitrobenzenes; Phosphoric Monoester Hydrolases; Platelet-Derived Growth Factor; PTEN Phosphohydrolase; Signal Transduction; Sulfonamides; Tissue Distribution; Tumor Suppressor Proteins | 2004 |
Inhibition of cyclooxygenase-1 and -2 expression by targeting the endothelin a receptor in human ovarian carcinoma cells.
Topics: Animals; Atrasentan; Blotting, Northern; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Endothelin A Receptor Antagonists; Endothelin-1; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Isoenzymes; Luciferases; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Nude; Nitrobenzenes; Ovarian Neoplasms; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyrrolidines; Receptor, Endothelin A; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Transfection; Up-Regulation; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2004 |
Expression and enzyme activity determination of human cyclooxygenase-1 and -2 in a baculovirus-insect cell system.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Baculoviridae; Cell Line, Tumor; Cells, Cultured; Cloning, Molecular; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Indomethacin; Isoenzymes; Leukemia, Myeloid; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Recombinant Proteins; Spodoptera; Sulfonamides | 2004 |
Sensitization of vanilloid receptor 1 induced by bradykinin via the activation of second messenger signaling cascades in rat primary afferent neurons.
Topics: Animals; Arachidonic Acids; Bradykinin; Calcium; Calcium Radioisotopes; Capsaicin; Cells, Cultured; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Estrenes; Ganglia, Spinal; Indomethacin; Inositol Phosphates; Ion Channels; Neurons, Afferent; Nitrobenzenes; Phosphodiesterase Inhibitors; Phospholipases A; Phospholipases A2; Pyrazoles; Pyrrolidinones; Rats; Rats, Wistar; Second Messenger Systems; Signal Transduction; Sulfonamides; TRPV Cation Channels; Type C Phospholipases | 2004 |
Role of prostaglandins and nitric oxide in the lipopolysaccharide-induced ACTH and corticosterone response.
Topics: Adrenocorticotropic Hormone; Animals; Arginine; Corticosterone; Cyclooxygenase Inhibitors; Guanidines; Hypothalamo-Hypophyseal System; Indomethacin; Lipopolysaccharides; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrobenzenes; Piroxicam; Pituitary-Adrenal System; Prostaglandins; Rats; Rats, Wistar; Sulfonamides | 2004 |
Down-regulation of interleukin-1alpha-induced matrix metalloproteinase-13 expression via EP1 receptors by prostaglandin E2 in human periodontal ligament cells.
Topics: Collagenases; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Humans; Indomethacin; Interleukin-1; Matrix Metalloproteinase 13; Nitrobenzenes; Periodontal Ligament; Receptors, Prostaglandin E; Sulfonamides | 2005 |
Celecoxib inhibits ureteral contractility and prostanoid release.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Celecoxib; Cyclooxygenase Inhibitors; Depression, Chemical; Dimethyl Sulfoxide; Dinoprost; Dinoprostone; Gas Chromatography-Mass Spectrometry; Humans; Indomethacin; Muscle Contraction; Nitrobenzenes; Prostaglandin Antagonists; Prostaglandin D2; Prostaglandins; Pyrazoles; Secretory Rate; Sulfonamides; Sus scrofa; Thromboxane A2; Tumor Necrosis Factor-alpha; Ureter; Ureteral Obstruction | 2005 |
Er:YAG laser irradiation increases prostaglandin E production via the induction of cyclooxygenase-2 mRNA in human gingival fibroblasts.
Topics: Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Induction; Fibroblasts; Gingiva; Humans; Indomethacin; Laser Therapy; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Wound Healing | 2005 |
Cyclo-oxygenase-2, endothelium and aortic reactivity during deoxycorticosterone acetate salt-induced hypertension.
Topics: Animals; Aorta; Cyclooxygenase 2; Desoxycorticosterone; Endothelium, Vascular; Hypertension; Indomethacin; Male; Nitrobenzenes; Oxidative Stress; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfonamides; Vasoconstriction | 2005 |
Selective inhibitors differentially affect cyclooxygenase-dependent pial arteriolar responses in newborn pigs.
Topics: Acetaminophen; Animals; Animals, Newborn; Arterioles; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Hypercapnia; Hypotension; Ibuprofen; Indomethacin; Male; Methacholine Chloride; Nitrobenzenes; Pia Mater; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Swine; Vasoconstriction; Vasodilation | 2005 |
Cytokines upregulate vascular endothelial growth factor secretion by human airway smooth muscle cells: Role of endogenous prostanoids.
Topics: Blotting, Western; Cell Survival; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytokines; Dactinomycin; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Humans; Indomethacin; Interleukin-1; Kinetics; Luciferases; Membrane Proteins; Muscle, Smooth; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides; Trachea; Transforming Growth Factor beta; Up-Regulation; Vascular Endothelial Growth Factor A | 2005 |
Cyclooxygenase-1 mediates the final stage of morphine-induced delayed cardioprotection in concert with cyclooxygenase-2.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cardiotonic Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Indomethacin; Ischemic Preconditioning, Myocardial; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Morphine; Myocardial Infarction; Myocardium; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Time Factors; Up-Regulation | 2005 |
Cyclooxygenase-2-dependent prostaglandin (PG) E2 downregulates matrix metalloproteinase-3 production via EP2/EP4 subtypes of PGE2 receptors in human periodontal ligament cells stimulated with interleukin-1alpha.
Topics: Analysis of Variance; Bucladesine; Cell Culture Techniques; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Down-Regulation; Humans; Indomethacin; Interleukin-1; Matrix Metalloproteinase 3; Membrane Proteins; Nitrobenzenes; Periodontal Ligament; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin E; Sulfonamides | 2005 |
Interleukin-1beta-induced prostaglandin E2 production by human gingival fibroblasts is upregulated by glycine.
Topics: Analysis of Variance; Cell Proliferation; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Fibroblasts; Gingiva; Glycine; Humans; Indomethacin; Interleukin-1; Interleukin-10; Membrane Proteins; Nitrobenzenes; Periodontal Diseases; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Up-Regulation | 2005 |
Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice.
Topics: Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Cells, Cultured; Chemokine CCL2; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Immunohistochemistry; Indomethacin; Lactones; Lipopolysaccharides; Liver Transplantation; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Sulfones; Transplantation, Heterologous; Tumor Necrosis Factor-alpha | 2005 |
Mast cell tryptase stimulates DLD-1 carcinoma through prostaglandin- and MAP kinase-dependent manners.
Topics: Benzamidines; Calcium; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase Inhibitors; Cytosol; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Guanidines; Humans; Immunohistochemistry; Indomethacin; Mast Cells; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitrobenzenes; Phosphorylation; Prostaglandins; Receptor, PAR-2; Serine Endopeptidases; Sulfonamides; Tryptases | 2005 |
Acetylcholine-induced endothelium-dependent contractions in the SHR aorta: the Janus face of prostacyclin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Aorta, Thoracic; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Imidazoles; In Vitro Techniques; Indomethacin; Nitrobenzenes; Prostaglandins; Prostaglandins I; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Salicylates; Sulfonamides; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents | 2005 |
Differential effects of COX inhibitors against beta-amyloid-induced neurotoxicity in human neuroblastoma cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cell Line, Tumor; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Indomethacin; Lipoxygenase Inhibitors; Membrane Proteins; Neuroblastoma; Neurons; Neuroprotective Agents; Nitrobenzenes; Peptide Fragments; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Signal Transduction; Sulfonamides | 2005 |
Ageing affects nitric oxide synthase, cyclooxygenase and oxidative stress enzymes expression differently in mesenteric resistance arteries.
Topics: Acetylcholine; Aging; Animals; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitrobenzenes; Oxidative Stress; Phenylephrine; Rats; Rats, Sprague-Dawley; Sulfonamides; Up-Regulation; Vascular Resistance; Vasoconstrictor Agents; Vasodilator Agents | 2005 |
Stimulation of prostaglandin E2 (PGE2) production by arachidonic acid, oestrogen and parathyroid hormone in MG-63 and MC3T3-E1 osteoblast-like cells.
Topics: Animals; Arachidonic Acid; Cell Line; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Estradiol; Humans; Indomethacin; Mice; Nitrobenzenes; Osteoblasts; Osteosarcoma; Parathyroid Hormone; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 2005 |
Local simvastatin effects on mandibular bone growth and inflammation.
Topics: Animals; Collagenases; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Fibronectins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indomethacin; Inflammation Mediators; Lactic Acid; Mandible; Matrix Metalloproteinase 13; Membranes, Artificial; Methylcellulose; Mice; Nitrobenzenes; Osteogenesis; Pharmaceutical Vehicles; Polyesters; Polymers; Procollagen; Rats; Simvastatin; Skull; Sulfonamides; Up-Regulation | 2005 |
Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli.
Topics: Animals; Blood-Brain Barrier; Brain; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gene Expression; In Situ Hybridization; Indomethacin; Inflammation; Intramolecular Oxidoreductases; Ketorolac; Lipopolysaccharides; Male; Mice; Nitrobenzenes; Plasmids; Prostaglandin-E Synthases; Pyrazoles; Sulfonamides | 2005 |
The immunosuppressive effects of ciprofloxacin during human mixed lymphocyte reaction.
Topics: B7-1 Antigen; B7-2 Antigen; CD40 Antigens; CD40 Ligand; Cell Proliferation; Ciprofloxacin; Coculture Techniques; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Immunosuppressive Agents; Indomethacin; Intercellular Adhesion Molecule-1; Interferon-gamma; Interleukin-12; Interleukin-18; Isoquinolines; Leukocytes, Mononuclear; Lymphocyte Culture Test, Mixed; Lymphocytes; Monocytes; Nitrobenzenes; Protein Kinase Inhibitors; Sulfonamides; T-Lymphocytes | 2006 |
Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells.
Topics: B-Lymphocytes; Cell Growth Processes; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprost; Dinoprostone; Enzyme Activation; Humans; Immunoglobulin Heavy Chains; Immunohistochemistry; Indomethacin; Isoxazoles; Leukemia, Lymphocytic, Chronic, B-Cell; Nitrobenzenes; Pyrazoles; Sulfonamides; Sulfones; Thromboxane A2 | 2006 |
Nonsteroidal anti-inflammatory drugs inhibit the growth of C6 and U138-MG glioma cell lines.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Flavonoids; Glioma; Humans; Indomethacin; Mitogen-Activated Protein Kinase Kinases; Nitrobenzenes; Protein Kinase Inhibitors; Pyrimidines; Rats; src-Family Kinases; Sulfonamides; Time Factors | 2006 |
Inhibitors of COX activity preserve muscle mass in mice bearing the Lewis lung carcinoma, but not the B16 melanoma.
Topics: Analysis of Variance; Animals; Cachexia; Carcinoma, Lewis Lung; Cyclooxygenase Inhibitors; Female; Indomethacin; Interleukin-6; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Neoplasms; Nitrobenzenes; RNA, Messenger; RNA, Neoplasm; Sulfonamides; Tumor Necrosis Factor-alpha | 2006 |
Dual, but not selective, COX-1 and COX-2 inhibitors, attenuate acetic acid-evoked bladder irritation in the anaesthetised female cat.
Topics: Acetic Acid; Anesthesia; Animals; Cats; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Indomethacin; Ketoprofen; Male; Nitrobenzenes; Piperazines; Reflex, Abnormal; Sodium Chloride; Sulfonamides; Thiazoles; Urinary Bladder Diseases | 2006 |
Role of bile acids, prostaglandins and COX inhibitors in chronic esophagitis in a mouse model.
Topics: Animals; Bile Acids and Salts; Chronic Disease; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Esophagitis, Peptic; Esophagus; Hydrochloric Acid; Indomethacin; Male; Mice; Mice, Inbred Strains; Mucous Membrane; Nitrobenzenes; Pepsin A; Prostaglandins; Radioimmunoassay; Severity of Illness Index; Sulfonamides | 2006 |
Dalteparin, a low molecular weight heparin, attenuates inflammatory responses and reduces ischemia-reperfusion-induced liver injury in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anticoagulants; Calcium; Cyclooxygenase 2 Inhibitors; Dalteparin; Edema; Endothelium; Epoprostenol; Fibrin Fibrinogen Degradation Products; Heparin; In Vitro Techniques; Indomethacin; Inflammation; Interleukin-12; Leukocytes; Liver; Liver Diseases; Male; Monocytes; Naphthalenes; Nitrobenzenes; Peroxidase; Propionates; Prospective Studies; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Sulfonamides; Transaminases; Tumor Necrosis Factor-alpha | 2006 |
Thromboxane mediates neutrophil superoxide production in pregnancy.
Topics: Arachidonic Acid; Aspirin; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female; Humans; Indomethacin; Neutrophils; Nitrobenzenes; Phospholipases A; Phospholipases A2; Pregnancy; Sulfonamides; Superoxides; Thromboxane-A Synthase; Thromboxanes | 2006 |
Cyclooxygenase 2 induced by Kaposi's sarcoma-associated herpesvirus early during in vitro infection of target cells plays a role in the maintenance of latent viral gene expression.
Topics: Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Endothelial Cells; Fibroblasts; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Viral; Herpesviridae Infections; Herpesvirus 8, Human; Humans; Indomethacin; Inflammation; Membrane Proteins; Nitrobenzenes; Open Reading Frames; Promoter Regions, Genetic; Sulfonamides; Transcription, Genetic; Ultraviolet Rays; Up-Regulation; Viral Envelope Proteins; Virus Latency; Virus Replication | 2006 |
Prostaglandin E2 release in gastric antral mucosa of guinea-pigs: basal PGE2 release by cyclo-oxygenase 2 and ACh-stimulated PGE2 release by cyclo-oxygenase 1.
Topics: Acetylcholine; Animals; Arachidonic Acid; Aspirin; Calcium; Cinnamates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Mucosa; Guinea Pigs; Indomethacin; Ionomycin; Male; Nitrobenzenes; ortho-Aminobenzoates; Phospholipases A; Pyloric Antrum; Pyrazoles; Sulfonamides | 2006 |
Effects of selective inhibition of cyclooxygenase and lipooxygenase pathways in follicle rupture and ovulation in the rat.
Topics: Animals; Chorionic Gonadotropin; Corpus Luteum; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Gonadotropins, Equine; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Nitrobenzenes; Ovarian Follicle; Ovulation; Pyrazoles; Rats; Rats, Wistar; Staining and Labeling; Sulfonamides | 2006 |
Roles of stretch-activated cation channel and Rho-kinase in the spontaneous contraction of airway smooth muscle.
Topics: Amides; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cations; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Gadolinium; Guinea Pigs; Imidazoles; In Vitro Techniques; Indomethacin; Intracellular Signaling Peptides and Proteins; Ion Channels; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Nifedipine; Nitrobenzenes; Protein Serine-Threonine Kinases; Pyrazoles; Pyridines; rho-Associated Kinases; Simvastatin; Stress, Mechanical; Sulfonamides; Trachea | 2006 |
Identification of specific genes and pathways involved in NSAIDs-induced apoptosis of human colon cancer cells.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caco-2 Cells; Caspases; Colonic Neoplasms; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Nitrobenzenes; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins c-bcl-2; Receptors, Tumor Necrosis Factor; Sulfonamides | 2006 |
Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer gamma-secretase modulators.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Indomethacin; Nitrobenzenes; Peptide Fragments; Sulfonamides | 2006 |
Role of prostacyclin in the development of compression trauma-induced spinal cord injury in rats.
Topics: Animals; Cyclooxygenase Inhibitors; Epoprostenol; Iloprost; Indomethacin; Male; Motor Activity; Neutrophil Infiltration; Nitrobenzenes; Rats; Rats, Wistar; RNA, Messenger; Spinal Cord Injuries; Sulfonamides; Thoracic Vertebrae; Tumor Necrosis Factor-alpha | 2006 |
Arachidonic acid inhibits osteoblast differentiation through cytosolic phospholipase A2-dependent pathway.
Topics: 3T3 Cells; Alkaline Phosphatase; Animals; Arachidonic Acid; Arachidonic Acids; Cell Differentiation; Cell Shape; Clone Cells; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Dinoprostone; Enzyme Inhibitors; Fibroblasts; Indomethacin; Mice; Nitrobenzenes; Organophosphonates; Osteoblasts; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; RNA, Messenger; Sulfonamides | 2007 |
An herbal medicine orengedokuto prevents indomethacin-induced enteropathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Duodenal Ulcer; Female; Gastrointestinal Hemorrhage; Herbal Medicine; Indomethacin; Injections, Subcutaneous; Interleukin-10; Intestinal Mucosa; Intestine, Small; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Nitrobenzenes; Sulfonamides; Survival Analysis; Survival Rate; Treatment Outcome | 2007 |
Long-term fenofibrate treatment impairs endothelium-dependent dilation to acetylcholine by altering the cyclooxygenase pathway.
Topics: Acetylcholine; Animals; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Endothelium, Vascular; Fenofibrate; In Vitro Techniques; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins F; Rats; Rats, Wistar; Sulfonamides; Time Factors; Vasodilation; Vasodilator Agents | 2007 |
Cyclooxygenase-1 inhibition delays recovery of the cutaneous barrier disruption caused by mechanical scratching in mice.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dermatitis, Atopic; Edema; Immunohistochemistry; Indomethacin; Male; Mice; Mice, Inbred BALB C; Nitrobenzenes; Plasma; Prostaglandins; Pruritus; Pyrazoles; Recovery of Function; Sulfonamides | 2007 |
Depolarization and decreased surface expression of K+ channels contribute to NSAID-inhibition of intestinal restitution.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Membrane; Cell Movement; Chromatography, High Pressure Liquid; Humans; Indomethacin; Intestinal Mucosa; Membrane Potentials; Nitrobenzenes; Patch-Clamp Techniques; Phenylbutazone; Polyamines; Shaker Superfamily of Potassium Channels; Signal Transduction; Spectrometry, Mass, Electrospray Ionization; Sulfonamides; Wound Healing | 2007 |
Inhibition of cyclooxygenase-2 down-regulates osteoclast and osteoblast differentiation and favours adipocyte formation in vitro.
Topics: Adipocytes; Animals; Cattle; Cell Differentiation; Cell Lineage; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; In Vitro Techniques; Indomethacin; Isoxazoles; Male; Mesenchymal Stem Cells; Mice; Nitrobenzenes; Osteoblasts; Osteoclasts; Rats; Rats, Sprague-Dawley; Sulfonamides | 2007 |
COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia.
Topics: Adenosine Triphosphate; Animals; Calcium Signaling; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Depression, Chemical; Diastole; Diclofenac; Disease Models, Animal; Glyburide; In Vitro Techniques; Indomethacin; Myocardial Contraction; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Nitrobenzenes; Perfusion; Potassium Channel Blockers; Potassium Channels; Rats; Reperfusion Injury; Research Design; Sulfonamides; Systole; Time Factors | 2007 |
Effects of cyclooxygenase (COX) inhibition on memory impairment and hippocampal damage in the early period of cerebral hypoperfusion in rats.
Topics: Animals; Astrocytes; Brain Ischemia; Carotid Stenosis; Cyclooxygenase Inhibitors; Disease Models, Animal; Hippocampus; Indomethacin; Male; Maze Learning; Memory Disorders; Microglia; Neurons; Nitrobenzenes; Rats; Rats, Wistar; Sulfonamides; Survival Analysis | 2007 |
Inhibitory effect of cyclooxygenase inhibitors on the step-through passive avoidance performance in mice treated with NC-1900, an arginine-vasopressin fragment analog.
Topics: Animals; Arginine Vasopressin; Avoidance Learning; Behavior, Animal; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Indomethacin; Male; Memory; Mice; Mice, Inbred Strains; Nitrobenzenes; Oligopeptides; Piroxicam; Pyrrolidonecarboxylic Acid; Sulfonamides | 2007 |
Role of prostaglandins in collecting duct-derived endothelin-1 regulation of blood pressure and water excretion.
Topics: Animals; Blood Pressure; Blotting, Western; Cyclic AMP; Cyclooxygenase Inhibitors; Dinoprostone; Endothelin-1; Indomethacin; Kidney Medulla; Kidney Tubules, Collecting; Mice; Mice, Knockout; Mice, Transgenic; Nitrobenzenes; Osmolar Concentration; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Renal Agents; Sodium; Sulfonamides; Telemetry; Vasopressins; Water | 2007 |
Involvement of COX-1 in A3 adenosine receptor-mediated contraction through endothelium in mice aorta.
Topics: Adenosine; Animals; Aorta; Benzofurans; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Indomethacin; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Knockout; Nitrobenzenes; Polymerase Chain Reaction; Pyrazoles; Pyridines; Receptor, Adenosine A3; Receptors, Thromboxane; RNA, Messenger; Signal Transduction; Sulfonamides; Thromboxane B2; Thromboxane-A Synthase; Vasoconstriction; Vasoconstrictor Agents | 2007 |
Peroxisome proliferator-activated receptor gamma is a target of progesterone regulation in the preovulatory follicles and controls ovulation in mice.
Topics: Anilides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Colforsin; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Female; Gene Deletion; Gene Expression Profiling; Gonadotropins; Granulosa Cells; Hormone Antagonists; Immunohistochemistry; In Situ Hybridization; Indomethacin; Mice; Mice, Knockout; Mifepristone; Models, Genetic; Nitrobenzenes; Ovarian Follicle; Ovary; Ovulation; PPAR gamma; Progesterone; Receptors, Progesterone; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 2008 |
Cyclooxygenase-1 suppresses lipopolysaccharide-induced changes in rat gastric inducible nitric oxide synthase.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Escherichia coli; Female; Gastric Mucosa; Immunity, Mucosal; Indomethacin; Lipopolysaccharides; Nitric Oxide Synthase Type II; Nitrobenzenes; Pyrazoles; Rats; Rats, Sprague-Dawley; Salicylates; Sulfonamides | 2008 |
Drug-induced alterations to gene and protein expression in intestinal epithelial cell 6 cells suggest a role for calpains in the gastrointestinal toxicity of nonsteroidal anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calpain; Cell Line; Cell Movement; Cyclooxygenase Inhibitors; Epithelial Cells; Gene Expression; Indomethacin; Intestinal Mucosa; Nitrobenzenes; Oligonucleotide Array Sequence Analysis; Pyrazoles; Rats; RNA, Messenger; Sulfonamides | 2008 |
Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity.
Topics: Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Synergism; Edema; Hot Temperature; Hyperalgesia; Indomethacin; Male; Metalloporphyrins; NF-kappa B; Nitrobenzenes; Pain; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Sulfonamides | 2008 |
Enhancement of 5-fluorouracil efficacy on high COX-2 expressing HCA-7 cells by low dose indomethacin and NS-398 but not on low COX-2 expressing HT-29 cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Separation; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Fluorouracil; HT29 Cells; Humans; Indomethacin; Methylenetetrahydrofolate Dehydrogenase (NADP); Microscopy, Fluorescence; Nitrobenzenes; Polymorphism, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Thymidylate Synthase | 2009 |
In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E(2) biosynthesis.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cymenes; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Monoterpenes; Nitrobenzenes; Sheep; Sulfonamides | 2009 |
Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; beta Catenin; Blotting, Western; Celecoxib; Colonic Neoplasms; Colonic Polyps; Disease Models, Animal; Female; Genes, APC; Humans; Indomethacin; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrobenzenes; PPAR delta; PPAR-beta; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sulfonamides; Tumor Cells, Cultured | 2009 |
Pyrazolo[3,4-d]pyrimidine derivatives as COX-2 selective inhibitors: synthesis and molecular modelling studies.
Topics: Animals; Anti-Inflammatory Agents; Computer Simulation; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Humans; Indomethacin; Models, Molecular; Nitrobenzenes; Pyrazoles; Pyrimidines; Sheep; Structure-Activity Relationship; Sulfonamides | 2009 |
Co-inhibition of cyclooxygenase-2 and dihydropyrimidine dehydrogenase by non-steroidal anti-inflammatory drugs in tumor cells and xenografts.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Colonic Neoplasms; Cyclooxygenase 2; Dihydrouracil Dehydrogenase (NADP); Female; Fluorescent Antibody Technique; Humans; Immunoenzyme Techniques; Indomethacin; Mice; Mice, SCID; Nitrobenzenes; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Transplantation, Heterologous; Tumor Cells, Cultured | 2009 |
Enhanced 5-fluorouracil cytotoxicity in high cyclooxygenase-2 expressing colorectal cancer cells and xenografts induced by non-steroidal anti-inflammatory drugs via downregulation of dihydropyrimidine dehydrogenase.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Collagen; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dihydrouracil Dehydrogenase (NADP); Dinoprostone; Down-Regulation; Drug Interactions; Extracellular Matrix; Fluorescent Antibody Technique; Fluorouracil; HT29 Cells; Humans; Indomethacin; Nitrobenzenes; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Xenograft Model Antitumor Assays | 2010 |
Possible involvement of microglia containing cyclooxygenase-1 in the accumulation of gonadotrophin-releasing hormone in the preoptic area in female rats.
Topics: Animals; Astrocytes; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Estrogens; Female; Flurbiprofen; Gonadotropin-Releasing Hormone; Indomethacin; Luteinizing Hormone; Membrane Proteins; Microglia; Neurons; Nitrobenzenes; Ovariectomy; Preoptic Area; Progesterone; Rats; Rats, Wistar; Sulfonamides; Time Factors | 2009 |
Cyclooxygenase-2 preserves flow-mediated remodelling in old obese Zucker rat mesenteric arteries.
Topics: Acetylcholine; Age Factors; Animals; Blood Pressure; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Hypertrophy; Indomethacin; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Nitrobenzenes; Obesity; Rats; Rats, Zucker; Regional Blood Flow; Splanchnic Circulation; Sulfonamides; Time Factors; Vascular Resistance; Vasodilation; Vasodilator Agents | 2010 |
The influence of constitutive COX-2 in smooth muscle tissue on the contractile effect of phenylephrine in the rat abdominal aorta.
Topics: Animals; Aorta, Abdominal; Cycloheximide; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Gene Expression Regulation; Immunoblotting; Indomethacin; Muscle Contraction; Muscle, Smooth; Nitrobenzenes; Phenylephrine; Phospholipase A2 Inhibitors; Pyrazoles; Rats; Sulfonamides; Type C Phospholipases | 2010 |
Prostaglandin-E2 is produced by adult human epidermal melanocytes in response to UVB in a melanogenesis-independent manner.
Topics: Adult; Arachidonic Acid; Dinoprostone; Epidermal Cells; Female; Humans; Hydrogen Peroxide; Indomethacin; Intramolecular Oxidoreductases; Keratinocytes; Male; Melanins; Melanocytes; Membrane Glycoproteins; Monophenol Monooxygenase; Nitrobenzenes; Oxidoreductases; Sulfonamides; Ultraviolet Rays; Young Adult | 2010 |
The apolipoprotein A-I mimetic peptide 4F prevents defects in vascular function in endotoxemic rats.
Topics: Animals; Apolipoprotein A-I; Blood Pressure; Blood Vessels; Cholesterol, HDL; Cyclooxygenase Inhibitors; Endotoxemia; Hemodynamics; Humans; Indomethacin; Lipopolysaccharides; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrobenzenes; Peptides; Phenylephrine; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfonamides; Vasoconstrictor Agents | 2010 |
Non-steroidal anti-inflammatory drugs inhibit calpain activity and membrane localization of calpain 2 protease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calpain; Cell Membrane; Cell Movement; Humans; Indomethacin; Nitrobenzenes; Pyrazoles; Sulfonamides | 2010 |
Prevotella intermedia induces prostaglandin E2 via multiple signaling pathways.
Topics: Cell Culture Techniques; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Humans; Indomethacin; JNK Mitogen-Activated Protein Kinases; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Phosphoinositide-3 Kinase Inhibitors; Prevotella intermedia; Protein Kinase C; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; Sulfonamides; Time Factors | 2011 |
[Application of non-steroidal anti-inflammatory drugs to enhance 5-fluorouracil efficacy in experimental systems].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Synergism; Fluorouracil; Gene Expression Regulation, Enzymologic; Humans; Indomethacin; Neoplasms; Nitrobenzenes; Sulfonamides; Transplantation, Heterologous | 2010 |
Endogenous prostaglandin E2 inhibits aberrant overgrowth of rheumatoid synovial tissue and the development of osteoclast activity through EP4 receptor.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Humans; Indomethacin; Nitrobenzenes; Osteoclasts; Receptors, Prostaglandin E, EP4 Subtype; Sulfonamides; Synovial Membrane | 2011 |
Ellagic acid facilitates indomethacin-induced gastric ulcer healing via COX-2 up-regulation.
Topics: Animals; Blotting, Western; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cytokines; Dinoprostone; Dose-Response Relationship, Drug; Ellagic Acid; Enzyme-Linked Immunosorbent Assay; Gastric Mucosa; Indomethacin; Intercellular Signaling Peptides and Proteins; Male; Mice; Molecular Structure; Nitrobenzenes; Peroxidase; Pyrazoles; Stomach Ulcer; Sulfonamides; Time Factors; Up-Regulation; Wound Healing | 2012 |
Expression of pleiotrophin, an important regulator of cell migration, is inhibited in intestinal epithelial cells by treatment with non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone and Bones; Carrier Proteins; Cell Line; Cell Movement; Cytokines; Epithelial Cells; Horses; Indomethacin; Intestinal Mucosa; Neovascularization, Pathologic; Nitrobenzenes; Oligonucleotide Array Sequence Analysis; Phenylbutazone; Sulfonamides; Tissue Distribution | 2012 |
Involvement of hypothalamic cyclooxygenase-2, interleukin-1β and melanocortin in the development of docetaxel-induced anorexia in rats.
Topics: Animals; Anorexia; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Docetaxel; Hypothalamus; Indomethacin; Interleukin-1beta; Male; Neoplasms; Nitrobenzenes; Pro-Opiomelanocortin; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Taxoids | 2012 |
Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; ErbB Receptors; Humans; Indomethacin; Ki-67 Antigen; Lipopolysaccharide Receptors; Lipopolysaccharides; Lung Neoplasms; Membrane Proteins; Mice; Nitrobenzenes; Sulfonamides; Toll-Like Receptor 4 | 2013 |
Increased cyclooxygenase-2-derived prostanoids contributes to the hyperreactivity to noradrenaline in mesenteric resistance arteries from offspring of diabetic rats.
Topics: Animals; Cells, Cultured; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Dinoprost; Endothelial Cells; Female; Immunoenzyme Techniques; Indomethacin; Male; Mesenteric Arteries; Nitrobenzenes; Norepinephrine; Pregnancy; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats; Sulfonamides; Thromboxane A2; Xanthones | 2012 |
Cyclooxygenase-2-related signaling in the hypothalamus plays differential roles in response to various acute stresses.
Topics: Adrenalectomy; Animals; Corticotropin-Releasing Hormone; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Hypoglycemia; Hypothalamus; Indomethacin; Interleukin-1beta; Intramolecular Oxidoreductases; Lipopolysaccharides; Male; Nitrobenzenes; Prostaglandin-E Synthases; Prostaglandins; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Restraint, Physical; RNA, Messenger; Signal Transduction; Stress, Psychological; Sulfonamides | 2013 |
Gliadin intake alters the small intestinal mucosa in indomethacin-treated HLA-DQ8 transgenic mice.
Topics: Animals; Apoptosis; Caspase 3; Celiac Disease; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Gliadin; GTP-Binding Proteins; HLA-DQ Antigens; Humans; Immunoglobulin A; Immunoglobulin G; Indomethacin; Intestinal Mucosa; Intestine, Small; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Transgenic; Nitrobenzenes; Oxidative Stress; Protein Glutamine gamma Glutamyltransferase 2; Sulfonamides; Time Factors; Transglutaminases | 2014 |
Vascular endothelial function is improved by oral glycine treatment in aged rats.
Topics: Acetylcholine; Aging; Animals; Aorta; Cyclooxygenase 1; Cyclooxygenase 2; Endothelium, Vascular; Glycine; Humans; Indomethacin; Interleukin-1beta; Male; NADPH Oxidase 4; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrobenzenes; Phenylephrine; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Superoxide Dismutase; Superoxides; Tumor Necrosis Factor-alpha | 2015 |
Treatment with high dose of atorvastatin reduces vascular injury in diabetic rats.
Topics: Animals; Aorta; Atorvastatin; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Endothelium, Vascular; Indomethacin; Male; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitrobenzenes; Phenylephrine; Prostaglandins; Rats; Rats, Wistar; Streptozocin; Sulfonamides; Superoxides; Vascular System Injuries; Vasodilation; Vasodilator Agents | 2016 |
Suppression of calpain expression by NSAIDs is associated with inhibition of cell migration in rat duodenum.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calpain; Cell Line; Cell Movement; Duodenum; Epithelial Cells; Indomethacin; Intestinal Mucosa; Male; Nitrobenzenes; Rats, Wistar; RNA, Small Interfering; Sulfonamides | 2017 |
Chloroquine Inhibits Self-Renewal of Blast Progenitors Synergistically With Phytochemicals or Nonsteroidal Anti-inflammatory Drugs in Hematological Malignant Cell Lines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Ascorbic Acid; Blast Crisis; Cell Line, Tumor; Cell Self Renewal; Chloroquine; Hematologic Neoplasms; Humans; Indomethacin; Neoplastic Stem Cells; Nitrobenzenes; Phytochemicals; Resveratrol; Stem Cells; Sulfonamides; Tumor Stem Cell Assay | 2019 |
Cyclooxygenase-dependent mechanisms mediate in part the anti-dilatory effects of perivascular adipose tissue in uterine arteries from pregnant rats.
Topics: Acetylcholine; Adipose Tissue; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Female; Indomethacin; Male; Membrane Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitrobenzenes; Pregnancy; Pyrazoles; Rats, Sprague-Dawley; Sulfonamides; Uterine Artery; Vasodilation; Vasodilator Agents | 2021 |