Compounds > n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide

n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and dinoprostone

n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide has been researched along with dinoprostone in 423 studies

Research

Studies (423)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's70 (16.55)18.2507
2000's272 (64.30)29.6817
2010's77 (18.20)24.3611
2020's4 (0.95)2.80

Authors

AuthorsStudies
Elagib, KE; Goldfarb, AN; Munson, KM; Peterson, RT; Sweetser, DA; Yeh, JR1
Endo, T; Hayashi, Y; Ogura, T; Ogushi, F; Sone, S; Taketani, Y; Ueda, N; Yamamoto, S1
Arai, I; Futaki, N; Hamasaka, Y; Higuchi, S; Otomo, S; Takahashi, S1
Cipollone, F; Cuccurullo, F; di Giamberardino, M; Greco, A; Padovano, R; Panara, MR; Patrono, C; Rotondo, MT; Santini, G; Sciulli, MG1
Harada, Y; Hatanaka, K; Katori, M; Kawamura, M; Majima, M; Ogino, K; Ogino, M; Ohno, T; Saito, M; Taketani, Y; Yamamoto, K; Yamamoto, S1
Arai, Y; Ishihara, O; Kinoshita, K; Kitagawa, H; Numari, H; Saitoh, M; Takanashi, H2
Kudo, I; Matsumoto, H; Murakami, M; Naraba, H; Oh-ishi, S; Ueno, A; Yamaki, K1
Kniss, DA; Perkins, DJ1
Mue, S; Niki, H; Ohuchi, K; Tominaga, Y; Watanabe-Kobayashi, M1
Bayly, C; Mancini, JA; Riendeau, D; Waterman, HL; Wong, E1
Cao, C; Matsumura, K; Watanabe, Y1
Kawaguchi, H; Koishihara, Y; Kubodera, N; Miyaura, C; Ohsugi, Y; Pilbeam, CC; Raisz, LG; Suda, T; Tai, H; Tamura, T1
Eidson, TH; Leffler, CW; Parfenova, H1
Bell, RL; Hulkower, KI; Otis, ER; Wernimont, AK1
Fujii, E; Irie, K; Muraki, T; Ogawa, A; Ohba, K; Yamakawa, M; Yoshioka, T1
Hirata, T; Kato, S; Takeuchi, K; Ukawa, H; Yamakuni, H1
Hirata, T; Kitamura, M; Takeuchi, K; Ukawa, H1
de Brum-Fernandes, AJ; Dumais, R; Lora, M; Maciel, FM; Morisset, S; Patry, C; Sarrazin, P1
Balabanova, L; Leffler, CW; Parfenova, H1
Huber, E; Leis, HJ; Windischhofer, W; Zach, D1
Doshi, V; Gropper, MA; Kudoh, I; Kurahashi, K; Ohara, M; Sawa, T; Wiener-Kronish, JP1
Kennedy, BP; Pruzanski, W; Stefanski, E; Vadas, P; van den Bosch, H1
Appleton, I; Bryant, CE; Mitchell, JA1
de Brum-Fernandes, AJ; Lora, M; Morisset, S; Patry, C1
Flanagan, AM; Lader, CS1
Harada, Y; Hatanaka, K; Kawamura, M; Ogino, K; Ogino, M; Ohno, T; Saito, M; Yang, Q1
Amann, R; Peskar, BA; Prenn, C; Schuligoi, R1
Abiko, Y; Goseki, T; Ohzeki, K; Ozawa, Y; Shimizu, N; Yamaguchi, M1
Cryer, HG; Fu, M; Lo, CJ; Lo, FR1
Epstein, SE; Ferrans, VJ; Huang, ES; Speir, E; Yu, ZX1
Gunawan, ES; Hori, M; Kawano, S; Nagano, K; Sawaoka, H; Takei, Y; Tsuji, S; Tsujii, M1
Holland, E; Knox, AJ; Pang, L2
Gamelli, R; He, LK; Liu, H; Shankar, R; Shoup, M1
Okabe, S; Shigeta, J; Takahashi, S1
Kato, S; Takeuchi, K; Ukawa, H; Yamakuni, H1
Kita, T; Nakashima, T; Shimada, K; Suzumura, A; Takayanagi, T; Yonetani, Y2
Catalioto, RM; Criscuoli, M; Cucchi, P; Lecci, A; Maggi, CA; Meini, S1
Dyer, RD; Gilbertsen, RB; Guglietta, A; Kraus, ER; Lesch, CA; Sanchez, B; Schrier, D; Song, Y1
Hara, K; Kong, DL; Sharp, FR; Weinstein, PR1
Brian, JE; Faraci, FM; Moore, SA1
Castonguay, A; Rioux, N1
Fujita, N; Fujita, T; Kage, K; Ogata, E; Oh-hara, T; Tsuruo, T1
Ciabattoni, G; Currò, D; Montuschi, P; Preziosi, P; Ragazzoni, E1
Kaminski, DL; Longo, WE; Mazuski, J; Panesar, N1
Abbracchio, MP; Bonazzi, A; Brambilla, R; Burnstock, G; Cattabeni, F; Ceruti, S1
Ahola, H; Carlstedt-Duke, J; Modéer, T; Yucel-Lindberg, T1
Gillespie, MT; Inoue, K; Ishiyama, S; Itoh, K; Kamatani, N; Kotake, S; Martin, TJ; Matsuzaki, K; Saito, S; Suda, T; Takahashi, N; Udagawa, N1
Gilbertsen, R; Guglietta, A; Kraus, ER; Lesch, CA; Sanchez, B1
Kaminski, D; Longo, WE; Mazuski, JE; Panesar, N1
Cao, HJ; Jennings, TA; Sciaky, D; Smith, TJ1
Chivers, J; Colville-Nash, PR; Gilroy, DW; Paul-Clark, MJ; Willis, D; Willoughby, DA1
Lorenz, RG; Newberry, RD; Stenson, WF1
Langenbach, R; Morham, SG; Young, DA; Zhang, X1
An, SJ; Ferreri, NR; McGiff, JC1
Balboa, MA; Balsinde, J; Dennis, EA; Johnson, CA1
Franzese, O; Mancuso, C; Navarra, P; Pistritto, G; Pozzoli, G; Preziosi, P; Tringali, G1
Kawai, M; Kawai, Y; Mashima, Y; Yamada, M1
Escalante, B; Ferreri, NR; Salgado, LM; Sanchez, PL1
Gleason, CE; Poitout, V; Robertson, RP; Tran, PO1
Ferguson, S; Hébert, RL; Laneuville, O1
Dwyer, JE; Gross, JM; Knox, FG1
Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Pajdo, R; Sliwowski, Z; Stachura, J1
Crew, TE; Elder, DJ; Paraskeva, C1
Barnard, DS; Billings, SD; Cheng, L; Crowell, PL; Heilman, DK; Lin, A; Marshall, MS; Marshall, SJ; Sweeney, CJ; Yip-Schneider, MT1
Fernández, AG; Godessart, N; Palacios, JM; Salcedo, C1
Poyser, NL1
Hirata, T; Kato, S; Kunikata, T; Takeuchi, K; Tanaka, A; Yamamoto, H1
Araki, H; Mizoguchi, H; Sugamoto, S; Suzuki, K; Takeuchi, K; Umdeda, M1
Kuroda, E; Sugiura, T; Yamashita, U; Yoshida, Y; Zeki, K1
Dieleman, LA; Langenbach, R; Morham, SG; Morteau, O; Sartor, RB; Sellon, R; Smithies, O1
Gross, GA; Harris, KC; Koki, A; Masferrer, JL; Muglia, LJ; Nelson, DM; Olson, LM; Sadovsky, Y1
Johnson, FC; Miller, MR; Poyser, NL1
Bartrons, R; Castaño, E; Gil, J1
Furuyama, S; Modéer, T; Nakao, S; Ogata, Y; Sugiya, H1
Diaz, FJ; Pyeon, D; Splitter, GA1
Cohn, S; Riehl, T; Schloemann, S; Stenson, WF; Tessner, T1
Chemtob, S; Clyman, RI; Heymann, MA; Lin, E; Roman, C; Takahashi, Y; Tse, MM1
Floyd, RA; Jacob, JM; Kotake, Y; Tabatabaie, T; Waldon, AM1
Claffey, K; Holland, JF; Kirschenbaum, A; Levine, AC; Liu, XH; Stearns, ME; Yao, S1
LaPointe, MC; Schuette, R1
Berl, T; Briggs, JP; Heasley, LE; Huang, Y; Schnermann, JB; Yang, T1
Elvin, JA; Matzuk, MM; Yan, C1
Beierwaltes, WH; Carretero, OA; Harding, P1
Attiga, FA; Fernandez, PM; Manyak, MJ; Patierno, SR; Weeraratna, AT1
Armstrong, J; French, JN; Gibbs, I; Knox, SJ; Ning, S; Steinauer, KK1
Hudetz, AG; Kampine, JP; Okamoto, H; Roman, RJ1
Fujita, T; Takahashi, S; Yamamoto, A2
Bahouth, SW; Fain, JN; Leffler, CW1
Concannon, EM; Daly, JM; Mackrell, PJ; Naama, HA; Schaefer, PA; Shaftan, GW; Stapleton, PP; Strong, VE1
Gunawan, ES; Hori, M; Iijima, H; Kakiuchi, Y; Kawai, N; Kawano, S; Kimura, A; Okuda, Y; Sasaki, Y; Sun, WH; Tsuji, S; Tsujii, M; Yasumaru, M1
Ghosh, AK; Hirasawa, N; Niki, H; Ohuchi, K1
Bahouth, SW; Fain, JN; Leffler, CW; Rice, AM; Rivkees, SA1
Daly, JM; Eisengart, CA; Mackrell, PJ; Mestre, JR; Murphy, EM; Naama, HA; Rivadeneira, DE; Stapleton, PP1
Harada, Y; Hatanaka, K; Kawamura, M; Ogino, K; Ohno, T1
Chang, HC; Chuang, LY; Hung, WC; Lee, TH; Pan, MR1
Brune, K; Hinz, B; Pahl, A1
Fazleabas, AT; Srisuparp, S; Strakova, Z1
Acquaviva, AM; Apicella, A; di Palma, A; Di Popolo, A; Memoli, A; Ricchi, P; Tuccillo, C; Zarrilli, R1
Hatori, M; Kamijo, R; Nagumo, M; Nakanishi, Y; Sumitani, K; Takizawa, K; Toyoshima, T1
Brzozowski, T; Drozdowicz, D; Hahn, E; Konturek, PC; Konturek, SJ; Kwiecień, S; Pajdo, R; Pawlik, M; Ptak, A; Sliwowski, Z1
Danon, A; Rimon, G; Rosenstock, M; Rubin, M1
Beneytout, JL; Le Bail, JC; Liagre, B; Moalic, S1
Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Nakamura, T; Pajdo, R; Pawlik, M; Ptak, A; Schuppan, D1
Beubler, E; Schuligoi, R1
Berger, S; Denkert, C; Hauptmann, S; Köbel, M; Leclere, A; Siegert, A; Trefzer, U1
Caughey, GE; Cleland, LG; Demasi, M; James, MJ1
Fresno, M; Grau, R; Hernández, GL; Iñiguez, MA; Lorenzo, E; Martínez-Martínez, S; Redondo, JM; Volpert, OV1
Donahue, A; Lindström, CL; Luo, J; Miller, MW1
Boyan, BD; Cochran, DL; Dean, DD; Liu, Y; Lohmann, CH; Schwartz, Z; Sisk, M; Sylvia, VL1
Jung, HC; Kim, CY; Kim, JM; Kim, JS; Song, IS1
Di Battista, JA; Fahmi, H; He, Y; Martel-Pelletier, J; Pelletier, JP; Zhang, M1
Kim, H; Kim, KH; Lim, JW1
Bielański, W; Bonior, J; Jachimczak, B; Jaworek, J; Konturek, PC; Konturek, SJ; Kot, M; Pawlik, WW; Sendur, R; Stachura, J; Tomaszewska, R1
Bellot, JL; Castillo, M; García-Cabanes, C; Orts, A; Palmero, M1
Endo, H; Ishikawa, I; Izumi, Y; Kondo, H; Nitta, H; Noguchi, K; Shitashige, M; Yotsumoto, Y1
Hains, BC; Hulsebosch, CE; Yucra, JA1
Dongari-Bagtzoglou, AI; Morton, RS1
Miyahara, T; Miyajima, S; Nemoto, N; Okajima, A; Sakuma, T; Takayama, K; Tonoyama, H; Watanabe, M1
Beubler, E; Chopra, AK; Peskar, BA; Ribardo, DA; Schuligoi, R1
Mark, KS; Miller, DW; Trickler, WJ1
Araki, H; Komoike, Y; Suzuki, K; Takeuchi, K; Umeda, M1
Concannon, EM; Daly, JM; Mack Strong, VE; Mackrell, PJ; Mestre, JR; Schaefer, PA; Smyth, GP; Stapleton, PP1
Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Pajdo, R; Ptak, A; Sliwowski, Z1
Ferguson, S; Hébert, RL; Laneuville, O; Nasrallah, R1
Gilroy, DW; Saunders, MA; Wu, KK1
Li, M; Wu, X; Xu, XC1
Grosset, C; Gualde, N; Harizi, H; Juzan, M; Rashedi, M1
Kim, JM; Manchanda, R; Tsang, BK1
Bahouth, SW; Ballou, LR; Fain, JN1
Chon, CY; Han, JH; Kang, JK; Kim, TI; Lee, KH; Lee, YC; Moon, YM; Park, IS1
Alcaraz, MJ; Guillén, MI; Vicente, AM1
Boyan, BD; Dean, DD; Del Toro, F; Hardin, RR; Schwartz, Z; Sylvia, VL1
Andurén, I; Brunius, G; Modéer, T; Wondimu, B; Yucel-Lindberg, T1
Bahouth, SW; Buffington, C; Cowan, GS; Fain, JN; Leffler, CW; Pouncey, L1
Chakraborty, C; Lala, PK; Rozic, JG1
Dorsey, R; Fulton, AM; Kundu, N; Yang, Q1
Barrera, N; Hermoso, M; Morales, B; Pérez, S; Villalón, M1
Daly, JM; Maddali, S; Mestre, JR; Schaefer, PA; Smyth, GP; Stapleton, PP; Strong, VE; Winter, J; Yan, Z; Yurt, RW1
Chen, GH; Mancuso, P; Peters-Golden, M; Phare, SM; Reddy, RC; Standiford, TJ; Tateda, K; Tsai, WC1
Church, T; Lahiri, T; Laporte, JD; Moore, PE; Panettieri, RA; Shore, SA1
Choudhry, MA; Fazal, N; Haque, F; Namak, SY; Ravindranath, T; Sayeed, MM1
Dormond, O; Foletti, A; Paroz, C; Rüegg, C1
An, SJ; Ferreri, NR; McGiff, JC; Wang, D; Wang, WH1
Araki, E; Dubinsky, JM; Forster, C; Iadecola, C; Ross, ME1
Fermor, B; Fink, C; Guilak, F; LeGrand, A; Pisetsky, DS; Vail, TP; Weinberg, JB1
Abe, M; Hori, T; Oka, T; Takahashi, S1
Alattar, MH; Choudhry, MA; Dallal, O; Muraskas, JK; Namak, SY; Ravindranath, TM; Sayeed, MM1
Higashio, K; Nakagawa, N; Tsuda, E; Yano, K; Yasuda, H1
Corbett, L; Holland, E; Knox, AJ; Pang, L; Stocks, J; Zhu, YM1
Ghosh, DK; Misukonis, MA; Pisetsky, DS; Reich, C; Weinberg, JB1
Chuang, LY; Hung, WC; Pan, MR1
Inoue, H; Mori, N; Tanabe, T; Yamamoto, N; Yoshida, T1
Bland, KI; Chaudry, IH; Cioffi, WG; Diodato, MD; Knöferl, MW; Schwacha, MG1
Arm, JP; Diaz, BL; Fujishima, H; Kanaoka, Y; Urade, Y1
Marathe, GK; McIntyre, TM; Pontsler, AV; St Hilaire, A; Zimmerman, GA1
Hirsch-Ernst, KI; Kahl, GF; Rüdell, G; Schäfer, D; Ziemann, C1
Barrett, KE; Resta-Lenert, S1
Shen, X1
Gan, H; Ouyang, Q; Zhang, Z1
Kuroda, E; Matsumoto, S; Matsumoto, T; Yamada, H; Yamada, T; Yamashita, U1
Chang, HW; Han, CK; Kang, SS; Kim, HP; Kwak, WJ; Park, BK; Son, KH1
Bazan, NG; Chen, C; Magee, JC1
Izon, DJ; Loftin, C; Spain, LM; Xu, H1
Eriksson, E; Hellstrand, M; Nilsson, CL1
Nishikawa, M; Saeki, Y; Yamaguchi, Y; Yoshitake, K1
Amuro, Y; Cheng, J; Hada, T; Imanishi, H1
Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Massicotte, F; Paredes, Y; Pelletier, JP1
Demetris, AJ; Han, C; Lunz, JG; Michalopoulos, G; Shelhamer, JH; Wu, T1
Corbett, L; Holland, E; Knox, AJ; Pang, L; Range, S; Rodgers, HC1
Aller, S; Briggs, J; Castrop, H; Endo, Y; Forrest, JN; Forrest, SJ; Pasumarthy, A; Schnermann, J; Stine, N; Yang, T1
Rana, B; Song, DH; Wolfe, MM; Yao, M1
Enomoto, U; Kanda, N; Nakai, K; Tani, K; Watanabe, S1
Arbab, F; Goldsby, JS; Huang, JC; Matijevic-Aleksic, N; Tumbusch, KJ; Wu, KK1
Daeschner, JC; Hansen, JT; Kerry O'Banion, M; Kyrkanides, S; Moore, AH; Olschowka, JA; Williams, JP1
Hrupka, BJ; Langhans, W; Lugarini, F; Plata-Salaman, CR; Schwartz, GJ1
Cheng, J; Hada, T; Imanishi, H; Iwasaki, A; Liu, W; Nakamura, H; Ueki, N1
Bolli, R; Kodani, E; Shinmura, K; Takano, H; Tang, XL; Xuan, YT1
Higashiyama, S; Hori, M; Kakiuchi, Y; Kawai, N; Kawano, S; Kimura, A; Komori, M; Sasaki, Y; Sun, WH; Tsuji, S; Tsujii, M; Yasumaru, M1
Bozza, PT; Pacheco, P; Weller, PF; Yu, W1
Dosoretz, A; Holland, JF; Kirschenbaum, A; Levine, AC; Liu, XH; Lu, M; Yao, S1
Half, E; Kuo, MT; Sinicrope, FA; Sun, Y; Tang, XM1
Humphrey, J; Mullan, M; Obregon, DF; Paris, D; Townsend, KP1
Fukuda, Y; Futagami, A; Ishizaki, M; Kawana, S; Yamanaka, N1
Bohlin, L; Huss, U; Perera, P; Ringbom, T; Vasänge, M1
Kanda, N; Watanabe, S1
Figueroa, JP; Liu, J; Mertz, HL; Rose, JC; Stallings, SP; Valego, NK1
Campell, WB; Isbell, MA; Kajdacsy-Balla, A; Kaul, S; Lindholm, PF; Nithipatikom, K1
Corbett, L; Knox, AJ; Nie, M; Pang, L1
Breuiller-Fouche, M; Cabrol, D; Dallot, E; Ferre, F; Leroy, MJ; Schmitz, T1
Chu, J; Knapp, B; Lloyd, FL; Rizzo, MT; Trifan, OC1
Hasan, M; Hillebrand, DJ; Hu, KQ; McCracken, JD; Mineyama, Y; Yu, CH1
Bradbury, DA; Knox, AJ; Pang, L; Sánchez-Alcázar, JA1
Alattar, MH; Choudhry, MA; Dallal, O; Kohn, A; Muraskas, JK; Namak, SY; Ravindranath, TM; Sayeed, MM1
Borgeat, P; Gilbert, C; Naccache, PH; Poubelle, PE; Pouliot, M1
Bissonnette, EY; Castonguay, A; Proulx, LI; Therriault, MJ1
Harada, R; Kobayashi, M; Nakata, H; Taguchi, H; Uemura, Y1
Elder, DJ; Eveson, JW; Hague, A; Huntley, S; Minter, HA1
Kim, HJ; Kim, MH; Lee, SK; Min, YI; Seo, DW1
Bakker, AD; Burger, EH; Klein-Nulend, J1
Wölfle, D1
Brittian, KR; Fan, Q; Gozal, D; Gozal, E; Guo, SZ; Kheirandish, L; Li, RC; Row, BW; Sachleben, LR1
Boscá, L; Fernández, AP; Leza, JC; Lizasoain, I; Lorenzo, P; Madrigal, JL; Moro, MA; Rodrigo, J1
Ibuki, T; Kobayashi, S; Matsumura, K; Nozaki, T; Tanaka, Y; Yamazaki, Y1
Alexander, JS; Itoh, M; Joh, T; Nomura, T; Ohara, H; Oshima, T; Sasaki, M; Seno, K; Takezono, Y; Yokoyama, Y1
Ito, D; Iwase, M; Kimura, T; Kondo, G; Nagumo, M; Ohashi, M; Watanabe, H1
Jänicke, RU; Schulze-Osthoff, K; Totzke, G1
Azemovic, D; Massoumi, R; Nielsen, CK; Sjölander, A1
Fortier, MA; Parent, J; Villeneuve, C1
Lorenz, RG; Newberry, RD; Riehl, TE; Stenson, WF1
Agostinis, P; de Witte, P; Hendrickx, N; Moens, U; Piette, J; Seternes, OM; Vandenheede, JR; Volanti, C1
Bortz, E; Cole, S; Herschman, H; Jia, Q; Martinez-Guzman, D; Rudra-Ganguly, N; Sun, R; Symensma, TL; Wu, TT1
Kennedy, JH; Korn, N; Thurston, RJ1
Crawford, F; Crescentini, R; Mullan, M; Paris, D; Patel, N; Quadros, A1
Daniel, PT; Denkert, C; Fürstenberg, A; Hauptmann, S; Köbel, M; Koch, I; Siegert, A; Weichert, W1
LaPointe, MC; Leung, A; Mendez, M; Tao, Z; Yang, XP1
Bradbury, D; Clayton, A; El-Haroun, H; Knox, AJ1
Ishii, K; Kubota, Y; Nakahara, T; Saito, M; Sakamoto, K1
Schmidt, CM; Wang, Y; Wiesenauer, C1
Arakawa, T; Fujiwara, Y; Higuchi, K; Matsumoto, T; Oshitani, N; Sasaki, E; Tarnawski, AS; Tominaga, K; Watanabe, T1
Akahoshi, M; Arinobu, Y; Harada, M; Inoue, Y; Miyake, K; Nagano, S; Nakashima, H; Niiro, H; Ninomiya, I; Ogami, E; Otsuka, T; Shimizu, S1
Hwang, SM; Lin, CH; Lin, CY; Shen, YH; Tsai, YC; Wu, SH1
Hamasaki, Y; Ishii, K; Matsuo, M; Yoshida, N; Zaitsu, M1
Alcaraz, MJ; Devesa, I; Ferrándiz, ML; Riguera, R1
Asselin, E; Gagnon, V; Mathieu, I; Parent, S; St-Germain, ME1
Cho, KH; Chung, JH; Eun, HC; Han, JH; Kim, KH; Park, CH; Park, KC; Roh, MS1
Brötzmann, K; Kahlke, V; Schafmayer, C; Schröder, J; Seidel, M; Stapela, S1
Horiuchi, Y; Mano, Y; Morita, I; Muneta, T; Nakahama, K; Onodera, M1
Holzer, RG; Jorcyk, CL; Ryan, RE; Schlekeway, E; Tommack, M1
Peters, MW; Pursley, JR; Smith, GW1
Harizi, H; Hedi, H; Norbert, G1
Arikawa, T; Morita, I; Omura, K1
Bagnato, A; Di Castro, V; Natali, PG; Nicotra, MR; Rosanò, L; Spinella, F1
Baumert, J; Prager, K; Prochnau, D; Rödel, J; Schmidt, KH; Straube, E1
Baek, SH; Choi, YA; Jeong, JH; Kang, SS; Lee, DJ; Lim, HK; Sonn, JK1
Bader, M; Cahová, M; Cervenka, L; Ganten, D; Husková, Z; Komers, R; Kramer, HJ; Skaroupková, P; Vanecková, I1
Dannenberg, AJ; Du, B; Friedman, SL; Hui, AY; Olinga, P; Subbaramaiah, K; Sung, JJ1
Gan, HT; Ouyang, Q; Zhang, ZH1
Futagami, S; Gudis, K; Hiratsuka, T; Kusunoki, M; Miyake, K; Sakamoto, C; Shinji, Y; Shinoki, K; Suzuki, K; Tatsuguchi, A; Tsukui, T; Wada, K1
Jiang, H; McIntyre, TM; Weyrich, AS; Zimmerman, GA1
Akaike, A; Banno, Y; Fushimi, K; Nakashima, S; Shimizu, K; Takigawa, M1
Fujii, K; Saito, M; Soshi, S; Tanaka, T1
Ishikawa, I; Noguchi, K; Ruwanpura, SM; Yan, M; Yoshida, N1
Busija, DW; Kis, B; Simandle, SA; Snipes, JA1
Bjorling, DE; Calamon-Dixon, JL; Jerde, TJ; Nakada, SY1
Anuar, F; Lu, J; Md, S; Mok, P; Moochhala, SM; Ng, KC; Siew Yang, KL1
Aoki, A; Ishikawa, I; Noguchi, K; Pourzarandian, A; Ruwanpura, SM; Watanabe, H1
Kim, H; Kokkotou, E; LaMont, JT; Moyer, MP; Na, X; Pothoulakis, C; Rhee, SH; Savidge, T1
Denkins, Y; Ferniz, M; Kempf, D; Marchetti, D; Nileshwar, S1
Abu-Soud, HM; Diamond, MP; Munkarah, AR; Saed, GM1
Bradbury, D; Corbett, L; Knox, AJ; Pang, L; Stocks, J1
Hsieh, CY; Huang, SP; Kuo, ML; Lin, JT; Shun, CT; Wang, HP; Wu, MS1
Jiang, X; Nakajima, Y; Ohno, K; Sato, S; Shi, E; Yue, H1
Barry, JM; Beer, TM; Corless, CL; Gantner, M; Garzotto, M; Loos, J; Wagner, M; Weksler, N1
Neufeld, AH; Zhang, X1
Kogo, H; Sakurai, T; Tamura, K1
Ishikawa, I; Noguchi, K; Ruwanpura, SM; Yan, M1
Siddiqui, A; Waris, G1
Boltz-Nitulescu, G; Jensen-Jarolim, E; Matejka, M; Rausch, WD; Rausch-Fan, X; Schedle, A; Ulm, C1
Iwagaki, H; Jikuhara, A; Mori, S; Nishibori, M; Takahashi, HK; Tanaka, N; Yoshii, M1
Iwai, K; Kanda, T; Morimoto, S; Nakahashi, T; Saegusa, S; Sumino, H; Takahashi, T; Zhu, SJ1
Ashkenazi, S; Vanichkin, A; Weizman, A; Yuhas, Y1
Kobayashi, Y; Kurihara, S; Ochi, T; Okafuji, N; Takahashi, N; Take, I; Tsuboi, H; Udagawa, N; Uematsu, S; Yamamoto, Y1
Claassen, N; Coetzee, M; Haag, M; Kruger, MC1
Cho, KH; Han, IO; Hwang, SY; Ji, KA; Joe, EH; Jung, JS; Kim, JY; Kim, TH; Lim, SJ; Oh, ES1
Arayankalayil, MJ; Coleman, CN; Palayoor, ST; Shoaibi, A1
Ferrario, A; Fisher, AM; Gomer, CJ; Rucker, N1
Attuwaybi, B; Kozar, RA; Moore, FA; Moore-Olufemi, SD; Sato, N; Weatherall, JM; Weisbrodt, NW; Zou, L1
Blais, V; Rivest, S; Turrin, NP1
Jiang, X; Nakajima, Y; Sato, S; Shi, E1
Brune, K; Hinz, B; Ramer, R; Rösch, S1
Kim, CM; Lee, CW; Lee, JA; Park, JE; Park, JW1
Ding, F; Liu, Z; Luo, A; Wang, L; Wu, M; Zhan, Q; Zhang, J; Zhi, H; Zhou, C1
Ha, H; Kim, HH; Kim, HM; Kim, HN; Kwak, HB; Lee, JH; Lee, S; Lee, ZH1
Iwase, M; Kondo, G; Nagumo, M; Ohashi, M; Takaoka, S; Uchida, M; Watanabe, H1
Iwagaki, H; Katsuno, G; Mizuno, K; Mori, S; Nishibori, M; Saito, S; Takahashi, HK; Tanaka, N; Yagi, T; Yoshino, T1
Bernstein, SH; Chiorazzi, N; Felgar, RE; Kaur, K; Phipps, RP; Pollock, SJ; Ryan, EP1
Brueggemeier, RW; Diaz-Cruz, ES; Landini, S; Su, B1
Boucher-Kovalik, S; Caron, N; Chapdelaine, P; Fortier, MA; Kang, J; Tremblay, JP1
Bonnans, C; Fukunaga, K; Levy, BD; Levy, MA1
Balasubramanian, L; Glass, WF; Harding, P; Stevens, A; Swegan, J1
Bartuzi, Z; McCallum, R; Poplawski, C; Sarosiek, J; Sosnowski, D; Szaflarska-Popławska, A1
Kasai, K; Kojima, T; Yamaguchi, M1
Duan, W; Zhang, L1
Arnold, B; Chadzinska, M; Kolaczkowska, E; Opdenakker, G; Plytycz, B; Scislowska-Czarnecka, A; van Rooijen, N1
Chandran, B; Naranatt, PP; Raghu, H; Sadagopan, S; Sharma-Walia, N; Sivakumar, R; Smith, MM; Veettil, MV1
Maehara, M; Matsumura, K; Sugiura, H; Takemiya, T; Yamagata, K; Yasuda, S1
Katsu, K; Kubota, T; Mori, H; Nakahari, T; Nakanishi, Y; Nakano, T; Shimamoto, C1
Hatano, Y; Jisaka, M; Miyata, N; Nagaya, T; Nishimura, K; Setoyama, T; Tsumagari, H; Xu, L; Yokota, K1
Barnes, AP; Kucera, GL; Miller, BE1
Ito, M; Iwamoto, J; Matsuoka, T; Miura, S; Mizokami, Y; Narasaka, T; Omata, T; Ootubo, T; Shimokobe, K; Takahashi, K; Takehara, H; Takeyama, H1
Hart, IR; Marshall, JF; McCulloch, D; Nystrom, ML; Speight, PM; Thomas, GJ; Violette, SM; Weinreb, PH1
Grubb, BD; Izydorczyk, I; Mayer, S; Reeh, PW1
Haneji, T; Nagata, T; Shinohara, H; Yoshida, K1
Fukutake, M; Iizuka, S; Imamura, S; Ishige, A; Ishimatsu, M; Kase, Y; Miura, N; Nakamura, Y; Ohtake, N; Takeda, S; Tsuchiya, N; Watanabe, K; Yamamoto, M1
Duan, WG; Jiang, ZZ; Liu, DQ; Yan, M; Yao, JC; Yun, Y; Zhang, LY1
Chang, HW; Kim, HP; Kim, YH; Park, H1
DeCoster, VA; Gay, DC; Tipton, DA1
Bushinsky, DA; Frick, KK; Krieger, NS; LaPlante Strutz, K; Michalenka, A1
Alander, C; Choudhary, S; Halbout, P; Pilbeam, C; Raisz, L1
Caso, JR; Hurtado, O; Lizasoain, I; Lorenzo, P; Moro, MA; Pradillo, JM1
Aras-López, R; Arroyo-Villa, I; Balfagón, G; Blanco-Rivero, J; Ferrer, M; Márquez-Rodas, I; Xavier, FE1
Abbadie, C; Bernard, D; Chelli, F; Debacq-Chainiaux, F; Gosselin, K; Martien, S; Toussaint, O; Vercamer, C; Zdanov, S1
Behar, J; Biancani, P; Cong, P; Pricolo, V1
Deasy, BM; McKenna, SL; O'Donovan, TR; O'Sullivan, GC; O'Sullivan-Coyne, G1
Aguejouf, O; Belon, P; Desplat, V; Doutremepuich, C; Eizayaga, FX1
Banu, N; Buda, A; Chell, S; Elder, D; Moorghen, M; Paraskeva, C; Pignatelli, M; Qualtrough, D1
Ge, Y; Kohan, DE; Strait, KA; Stricklett, PK; Yang, T1
Choe, M; Choi, EM; Ha, KS; Han, JA; Kim, H; Kim, JI; Kim, SR; Kim, SS; Kim, YM; Lee, EJ; Park, JH1
Distler, JH; Distler, O; Gay, S; Ha, HR; Huber, LC; Jüngel, A; Kalden, JR; Pisetsky, DS; Schulze-Horsel, U; Simmen, B1
Fujishiro, T; Hashimoto, S; Hasuda, K; Hayashi, S; Kurosaka, M; Niikura, T; Nishiyama, T; Suzuki, Y1
Glass, M; Keelan, JA; Mitchell, MD; Ponnampalam, AP; Sato, TA; Wang, A1
Fujii, Y; Okamoto, K; Sato, M; Takahashi, E; Tsurumi, K1
Akira, S; Kito, T; Kuroda, E; Nakano, Y; Nishizawa, S; Uematsu, S; Yamashita, U; Yokota, A1
Bai, Z; Wang, S; Ye, Y; Zhang, H1
Bagnoli, P; Cammalleri, M; Casini, G; Cervia, D; Martini, D; Pavan, B; Ristori, C1
Bhave, VS; Donthamsetty, S; Latendresse, JR; Mehendale, HM1
Kadonosono, K; Kamei, J; Ohnaka, K; Tanaka, S; Utsunomiya, H; Yamakawa, T1
Giles, JR; Johnson, PA; Urick, ME1
Chen, N; Du, Y; Luan, M; Wang, Z; Yang, X; Zhang, S; Zhou, W1
Clarkin, CE; Garonna, E; Pitsillides, AA; Wheeler-Jones, CP1
Ahmadi, M; Emery, DC; Morgan, DJ1
Chang, KC; Choi, HC; Kang, YJ; Kim, HS; Lee, KY1
Fabian, J1
Katono, T; Kawato, T; Kitami, S; Maeno, M; Morita, T; Motohashi, M; Suzuki, N; Tanabe, N; Tanaka, H1
Breyer, RM; Chen, C; Yang, H; Zhang, J1
Eichele, K; Hinz, B; Ramer, R1
Dercho, RA; Di Francesco, A; Di Francesco, L; Dovizio, M; Evangelista, V; Pandolfi, A; Patrignani, P; Piccoli, A; Salvatore, T; Seta, F; Totani, L1
Kokoska, L; Landa, P; Marsik, P; Pribylova, M; Vanek, T1
Chang, KC; Kim, HJ; Lee, JH; Nizamutdinova, IT; Seo, HG1
Hoecker, M; Juettner, S; Meyer, TF; Naumann, M; Stolte, M; Vieth, M; Walduck, AK; Weber, M; Wiedenmann, B; Wunder, C1
Alander, CB; Breyer, MD; Gao, Q; Hao, C; Kream, BE; Pilbeam, CC; Raisz, LG; Zhan, P1
Grammas, P; Rao, HV; Thirumangalakudi, L1
Abdelrazik, H; Becchetti, F; Moretta, L; Spaggiari, GM1
Destache, CJ; Ohia, SE; Opere, CA; Zhao, M1
Aras-López, R; Balfagón, G; Ferrer, M; Martorell, A; Sagredo, A1
Ganesan, A; Haglund, C; Hemmes, A; Junnila, S; Kokkola, A; Monni, O; Mrena, J; Nykänen, A; Petrova, TV; Ristimäki, A; Tai, HH; Thiel, A1
Fouladi-Nashta, AA; Marei, WF; Wathes, DC1
Harada, T; Miyakoda, H; Takai, E; Takenaka, Y; Taniguchi, F; Terakawa, N1
Adleff, V; Budai, B; Jeney, A; Kralovánszky, J; Pap, E; Réti, A1
Bak, EJ; Cha, JH; Chung, WY; Jang, S; Kim, JM; Kim, M; Yoo, YJ1
Calixto, JB; Duarte, FS; Figueiredo, CP; Medeiros, R; Pandolfo, P; Passos, GF; Prediger, RD1
Dumont, Y; Ma, W; Quirion, R; Vercauteren, F1
Yasuda, T1
Brownrigg, M; Gledhill, K; Haylett, AK; Masoodi, M; Nicolaou, A; Rhodes, LE; Thody, AJ; Tobin, DJ1
Chotjumlong, P; Khongkhunthian, S; Krisanaprakornkit, S; Ongchai, S; Reutrakul, V1
An, RH; Bai, YF; Ding, Q; Wang, YQ1
Chang, HW; Hung, SL; Lai, YL; Lee, YY; Liu, TY; Wu, CY1
Chan, MM; Moore, AR1
Kondo, A; Matsuda, T; Togari, A; Tsunashima, Y1
Fang, JF; Guo, WP; Liu, JP; Wei, HB; Zheng, ZH2
Ferrario, A; Gomer, CJ1
Adhyapak, AA; Ashfaque, SM; Benade, VS; Hebballi, V; Khan, FR; Kulkarni, NM; Mahat, MY; Patil, BM; Thippeswamy, BS; Tubachi, S; Vishwakarma, SL1
Guo, C; Guo, RW; Liu, H; Qi, F; Wang, XM; Yang, LX; Ye, JS1
Kuo, CD; Lin, IC1
Goldmann, O; Hecht, A; Hertzén, E; Lehne, S; Medina, E; Norrby-Teglund, A; Schmidt, H1
Alvarez, S; Blanco, A; Fresno, M; Muñoz-Fernández, MÁ1
Holopainen, IE; Järvelä, JT; Kukko-Lukjanov, TK; Lopez-Picon, FR; Plysjuk, A; Ruohonen, S1
Lin, YM; Powell, DW; Sarna, SK; Shi, XZ1
Fu, SM; Guan, SM; He, JJ; Zhang, M1
He, L; Li, W; Zhang, Y; Zhou, P1
Liu, J; Qian, X; Zhang, J1
Kumar, M; Nerurkar, VR; Verma, S1
Bae, S; Cho, BJ; Hwang, YI; Kang, JS; Kim, H; Kim, HN; Kim, HR; Kim, YS; Kong, JM; Lee, N; Lee, SK; Lee, WJ1
Ma, W; St-Jacques, B1
Honda, K1
Asarian, L; Geary, N; Hrupka, B; Kopf, BS; Langhans, W1
Gunji, Y; Hishinuma, M; Kawashima, I; Nishimura, R; Okamoto, M; Okazaki, T; Shimada, M; Yamashita, Y1
Cerella, C; Dicato, M; Diederich, M; Sobolewski, C1
Akaogi, J; Ito, H; Kanaji, T; Komagata, T; Maruyama, T; Mitomi, H; Mori, T; Nomoto, S; Ozaki, S; Shibata-Nozaki, T; Yamada, H1
Diaz, BL; Gentile, LB; Piva, B1
Lin, YM; Sarna, SK; Shi, XZ1
Li, Y; Wang, H; Wei, X; Wu, Y; Xu, Z; Yang, P; Zhao, L; Zhao, Z1
Chen, L; Gao, C; Zhang, G; Zhang, X; Zhong, W; Zhu, Y1
Cruz Duarte, P; Ma, W; St-Jacques, B1
Bayard, F; Chen, K; Chi, Y; Du, WT; Han, ZB; Han, ZC; Ji, YR; Liang, L; Wang, D; Yang, ZX1
Bandyopadhyay, SK; Chatterjee, A; Chatterjee, S; Chattopadhyay, S; Das, S; Saha, A1
Banat, GA; Dahlem, G; Eul, B; Fink, L; Goldmann, T; Grandel, U; Grimminger, F; Hattar, K; Lang, DS; Savai, R; Schermuly, RT; Schmall, A; Seeger, W; Sibelius, U; Subtil, FS; Vollmer, E; Wilhelm, J1
Bolscher, JG; Buranaphatthana, W; Chotjumlong, P; Krisanaprakornkit, S; Nazmi, K; Reutrakul, V; Supanchart, C1
Baek, YH; Choi, DY; Huh, JE; Kang, JW; Lee, JD; Nam, D; Park, DS1
Baliga, MS; Fayad, R; Fletcher, E; Graves, K; Greene, J; Jung, SH; Kaur, K; Nottingham, JM; Petroni, M; Ponemone, V; Saxena, A; Sheppe, JA1
Liang, Y; Wang, J; Wang, M; Wang, X1
Harris, HE; Idborg, H; Jakobsson, PJ; Korotkova, M; Leclerc, P; Wähämaa, H1
Li, X; Li, Y; Tan, L; Tang, T; Wang, J; Wu, Y; Xu, Z; Yang, P; Zhao, L; Zhao, Z1
Alimasi, W; Endo, K; Kosaka, T; Sawaji, Y; Shishido, T; Suzuki, H; Yamamoto, K; Yorifuji, M1
Jia, Y; Lin, J; Mi, Y; Zhang, C1
Cho, MS; Choi, JY; Kang, JL; Lee, YJ; Yoon, YS1
Cai, Y; Chen, S; Feng, X; Gao, S; Huang, X; Li, H; Li, Q; Liu, P; Liu, Z; Lu, J; Ye, J1
Chen, X; Fan, Y; Guo, N; Han, J; Yang, B; Zhang, L1
Nemoto, E; Shimauchi, H; Suzuki, R1
Chong, Y; Gao, Z; Gu, Y; Huang, Z; Tai, Q; Wang, F; Xie, C; Ye, Y; Zhang, M; Zhao, Q; Zheng, Y; Zhu, J1
Chang, HM; Cheng, JC; Leung, PC; Qiu, X1
Fu, X; Li, Q; Liu, N; Liu, X; Sui, H; Wang, Y; Wu, Q; Ye, N; Yu, NA; Zhou, L; Zhou, N1
Dahlem, G; Eul, B; Franz, K; Grandel, U; Grimminger, F; Hattar, K; Lohmeyer, J; Ludwig, M; Savai, R; Seeger, W; Sibelius, U; Subtil, FS; Wilhelm, J1
Andrade, BB; Araújo-Santos, T; Barral, A; Borges, VM; Bozza, PT; Brodskyn, CI; França-Costa, J; Luz, NF; Miranda, JC; Prates, DB1
Baranowska-Bosiacka, I; Chlubek, D; Gutowska, I; Korbecki, J; Kurzawski, M; Olszowski, T; Piotrowska, K1
Honda, KL; Lamon-Fava, S; Lichtenstein, AH; Matthan, NR; Wu, D1
Przygodzka, P; Przygodzki, T; Talar, M; Watala, C1
Bahia, MT; Diniz, LF; Moraes, KC1
Fan, X; Li, X; Ren, G; Ren, H; Sun, L; Wang, Y1
Aroonrerk, N; Niyomtham, N; Yingyoungnarongkul, BE1
Hao, XQ; Tian, YT; Zhang, LM; Zhang, YP1
Gao, B; Li, J; Li, Z; Wang, J; Wang, Y; Xu, H; You, K1
Guan, PP; Su, YN; Wang, P; Wang, ZY; Yu, X; Zhang, LC1
Choi, YH; Kang, JL; Lee, YJ; Park, YM; Yoon, YS1
Ou, HL; Peng, YC; Sun, D; Wu, YL1
Cheng, S; Gong, W; Huang, S; Jia, Z; Li, S; Mungun, HK; Sun, Z; Xia, W; Yu, J; Zhang, A; Zhang, Y1
Gren, ECK; Hayes, WK; Kelln, W; Kim, CH; Lekic, T; McBride, DW; Person, CE; Sherchan, P; Tang, J; Zhang, JH1
Chen, YH; Huang, CH; Lee, JC; Liaw, CC; Lin, CK; Lin, CY; Tseng, CK; Wu, YH1
Chen, P; Cheng, B; Ge, M; Hu, Y; Huang, L; Lai, D; Qiu, G; Shu, Q; Tong, H; Xu, J; Zheng, G1
Deng, X; Ding, G; Huang, S; Jia, Z; Liang, J; Zhang, A; Zhang, Y; Zhao, F; Zhuang, Y1
Bizzarri, M; Catizone, A; Coluccia, P; Cucina, A; de Toma, G; Dinicola, S; Fabrizi, G; Masiello, MG; Proietti, S; Ricci, G1
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Bouvet-Bouchard, L; Gauthier, MF; Julien, F; Labrecque, J; Michaud, A; Pelletier, M; Tchernof, A1
Fushiki, R; Matsuike, R; Mayahara, K; Shimizu, N; Takahashi, Y1
Caixeta, FMC; Dode, MAN; Franco, MM; Kawamoto, TS; Kussano, NR; Leme, LO; Pfeifer, LFM; Pontelo, TP; Rodrigues, SAD1
Cheng, F; Erxia, S; Juanjuan, T; Lan, C; Qi, Z; Ting, H; Xiaofang, J; Zi, L1
Al-Eidi, H; Alatar, G; AlGaith, N; Aljudayi, M; AlRoshody, R; El-Obeid, A; Hassib, A; Khan, AH; Maashi, Y; Matou-Nasri, S1
Arruda, SM; Carvalho, EM; Carvalho, LP; Nascimento, MT; Peixoto, FC; Viana, DL1

Other Studies

423 other study(ies) available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and dinoprostone

ArticleYear
Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation.
    Nature chemical biology, 2009, Volume: 5, Issue:4

    Topics: Animals; Animals, Genetically Modified; beta Catenin; Cell Differentiation; Dinoprostone; Gene Expression Regulation; Humans; K562 Cells; Nitrobenzenes; Oncogene Proteins; Small Molecule Libraries; Sulfonamides; Transcription Factors; Zebrafish; Zebrafish Proteins

2009
Induction of cyclooxygenase-2 is responsible for interleukin-1 beta-dependent prostaglandin E2 synthesis by human lung fibroblasts.
    American journal of respiratory cell and molecular biology, 1995, Volume: 12, Issue:3

    Topics: Base Sequence; Cells, Cultured; Cycloheximide; Dactinomycin; Dexamethasone; Dinoprostone; DNA Primers; Enzyme Induction; Fibroblasts; Gene Expression; Humans; In Vitro Techniques; Indomethacin; Interleukin-1; Interleukin-4; Lung; Molecular Sequence Data; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides

1995
Selective inhibition of NS-398 on prostanoid production in inflamed tissue in rat carrageenan-air-pouch inflammation.
    The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:8

    Topics: 6-Ketoprostaglandin F1 alpha; Air Sacs; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dinoprostone; Exudates and Transudates; Gastric Mucosa; Indomethacin; Inflammation; Kidney; Nitrobenzenes; Prostaglandins; Rats; Respiratory Tract Diseases; Sulfonamides; Thromboxane B2

1993
Effects of the novel anti-inflammatory compounds, N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulphonamide (NS-398) and 5-methanesulphonamido-6-(2,4-difluorothio-phenyl)-1-inda none (L-745,337), on the cyclo-oxygenase activity of human blood prostaglandin
    British journal of pharmacology, 1995, Volume: 116, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Blotting, Western; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Induction; Female; Humans; In Vitro Techniques; Indans; Ketoprofen; Male; Middle Aged; Monocytes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein Binding; Stereoisomerism; Sulfonamides; Thromboxane B2

1995
Role of prostaglandin H synthase-2 in prostaglandin E2 formation in rat carrageenin-induced pleurisy.
    Prostaglandins, 1996, Volume: 51, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents; Azo Compounds; Blotting, Western; Carrageenan; Cell Count; Cells, Cultured; Coloring Agents; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Excipients; Inflammation; Isoenzymes; Leukocytes; Male; Nitrobenzenes; Pleura; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Thromboxane B2; Trypan Blue

1996
Prostaglandin E2 production by endogenous secretion of interleukin-1 in decidual cells obtained before and after the labor.
    Prostaglandins, 1996, Volume: 52, Issue:3

    Topics: Blotting, Western; Cesarean Section; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Decidua; Dinoprostone; Dose-Response Relationship, Drug; Female; Humans; Interleukin-1; Isoenzymes; Labor, Obstetric; Membrane Proteins; Nitrobenzenes; Pregnancy; Prostaglandin-Endoperoxide Synthases; Receptors, Interleukin-1; Sulfonamides

1996
Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages.
    Biochemical and biophysical research communications, 1997, Jan-03, Volume: 230, Issue:1

    Topics: Animals; Cells, Cultured; Cycloheximide; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dactinomycin; Dinoprostone; Enzyme Induction; Indomethacin; Intramolecular Oxidoreductases; Isoenzymes; Isomerases; Kinetics; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Male; Nitrobenzenes; Prostaglandin D2; Prostaglandin-E Synthases; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfonamides; Thromboxane B2

1997
Rapid and transient induction of cyclo-oxygenase 2 by epidermal growth factor in human amnion-derived WISH cells.
    The Biochemical journal, 1997, Feb-01, Volume: 321 ( Pt 3)

    Topics: Amnion; Blotting, Northern; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Epidermal Growth Factor; Gene Expression Regulation, Developmental; Humans; Isoenzymes; Kinetics; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides; Tumor Necrosis Factor-alpha

1997
Possible participation of cyclooxygenase-2 in the recurrence of allergic inflammation in rats.
    European journal of pharmacology, 1997, Feb-12, Volume: 320, Issue:2-3

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Exudates and Transudates; Granulation Tissue; Hypersensitivity; Indomethacin; Inflammation; Isoenzymes; Leukocytes; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors

1997
Conversion of prostaglandin G/H synthase-1 into an enzyme sensitive to PGHS-2-selective inhibitors by a double His513 --> Arg and Ile523 --> val mutation.
    The Journal of biological chemistry, 1997, Apr-04, Volume: 272, Issue:14

    Topics: Amino Acid Sequence; Arginine; Binding Sites; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Histidine; Humans; Isoenzymes; Isoleucine; Membrane Proteins; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship; Sulfonamides; Thiophenes; Valine

1997
Possible role of cyclooxygenase-2 in the brain vasculature in febrile response.
    Annals of the New York Academy of Sciences, 1997, Mar-15, Volume: 813

    Topics: Animals; Brain; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Fever; Gene Expression Regulation; Isoenzymes; Lipopolysaccharides; Neurons; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; RNA, Messenger; Sulfonamides

1997
Transcriptional induction of cyclooxygenase-2 in osteoblasts is involved in interleukin-6-induced osteoclast formation.
    Endocrinology, 1997, Volume: 138, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Blotting, Northern; Bone Marrow Cells; Cells, Cultured; Coculture Techniques; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; DNA Primers; Enzyme Induction; Indomethacin; Interleukin-1; Interleukin-6; Isoenzymes; Male; Mice; Mice, Inbred Strains; Nitrobenzenes; Osteoblasts; Osteoclasts; Polymerase Chain Reaction; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Receptors, Interleukin; Receptors, Interleukin-6; Sulfonamides; Transcription, Genetic

1997
Upregulation of COX-2 in cerebral microvascular endothelial cells by smooth muscle cell signals.
    The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 1

    Topics: Animals; Animals, Newborn; Arachidonic Acid; Brain; Cell Nucleus; Cells, Cultured; Cerebrovascular Circulation; Coculture Techniques; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Dexamethasone; Dinoprostone; Endothelium, Vascular; Enzyme Induction; Gene Expression Regulation, Enzymologic; Ionomycin; Isoenzymes; Kinetics; Microcirculation; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfonamides; Swine

1997
Stimulus dependence of non-steroidal antiinflammatory drug potency in a cellular assay of prostaglandin H synthase-2.
    European journal of pharmacology, 1997, Jul-16, Volume: 331, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Drug Interactions; Humans; Ibuprofen; Indans; Indomethacin; Interleukin-1; Meclofenamic Acid; Nitrobenzenes; Okadaic Acid; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides; Tumor Necrosis Factor-alpha

1997
Role of nitric oxide, prostaglandins and tyrosine kinase in vascular endothelial growth factor-induced increase in vascular permeability in mouse skin.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Cycloheximide; Dinoprostone; Endothelial Growth Factors; Enzyme Inhibitors; Extravasation of Diagnostic and Therapeutic Materials; Genistein; Guanidines; Indomethacin; Lymphokines; Male; meta-Aminobenzoates; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrobenzenes; Phenols; Prostaglandins; Protein-Tyrosine Kinases; Salicylates; Skin; Stereoisomerism; Sulfonamides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

1997
Cyclo-oxygenase isozymes in mucosal ulcergenic and functional responses following barrier disruption in rat stomachs.
    British journal of pharmacology, 1997, Volume: 122, Issue:3

    Topics: Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Edema; Gastric Acid; Gastric Mucosa; Indomethacin; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Rats; Stomach; Stomach Ulcer; Sulfonamides; Taurocholic Acid

1997
Effects of selective cyclooxygenase-2 inhibitors on alkaline secretory and mucosal ulcerogenic responses in rat duodenum.
    Life sciences, 1997, Volume: 61, Issue:16

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bicarbonates; Cyclooxygenase Inhibitors; Dinoprostone; Duodenal Ulcer; Duodenum; Gastric Acid; Histamine; Hydrogen-Ion Concentration; Indomethacin; Intestinal Mucosa; Male; Nitrobenzenes; Rats; Rats, Sprague-Dawley; Sulfonamides

1997
Induction of cyclooxygenase-2 by parathyroid hormone in human osteoblasts in culture.
    The Journal of rheumatology, 1997, Volume: 24, Issue:12

    Topics: Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gene Expression Regulation; Humans; Interleukin-1; Isoenzymes; Membrane Proteins; Nitrobenzenes; Osteoblasts; Parathyroid Hormone; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides; Tumor Necrosis Factor-alpha

1997
Posttranslational regulation of cyclooxygenase by tyrosine phosphorylation in cerebral endothelial cells.
    The American journal of physiology, 1998, Volume: 274, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Animals, Newborn; Aorta; Cells, Cultured; Cerebral Cortex; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Membrane Proteins; Microcirculation; Muscle, Smooth, Vascular; Nitriles; Nitrobenzenes; Phenols; Phosphoproteins; Phosphorylation; Phosphotyrosine; Prostaglandin-Endoperoxide Synthases; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Sulfonamides; Swine; Tyrphostins; Vanadates

1998
Prostaglandin endoperoxide synthase-2 contributes to the endothelin/sarafotoxin-induced prostaglandin E2 synthesis in mouse osteoblastic cells (MC3T3-E1): evidence for a protein tyrosine kinase-signaling pathway and involvement of protein kinase C.
    Endocrinology, 1998, Volume: 139, Issue:3

    Topics: 3T3 Cells; Animals; Cyclic AMP; Dinoprostone; Endothelins; Mice; Nitrobenzenes; Osteoblasts; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Endothelin; RNA, Messenger; Sulfonamides; Viper Venoms

1998
Prostaglandin E2 production by endogenous secretion of interleukin-1 in decidual cells from term fetal membrane.
    Advances in experimental medicine and biology, 1997, Volume: 433

    Topics: Cesarean Section; Cyclooxygenase Inhibitors; Decidua; Delivery, Obstetric; Dinoprostone; Female; Humans; Interleukin-1; Labor, Obstetric; Nitrobenzenes; Pregnancy; Sulfonamides

1997
Induction of cyclooxygenase-2 in alveolar macrophages after acid aspiration: selective cyclooxygenase-2 blockade reduces interleukin-6 production.
    Anesthesiology, 1998, Volume: 88, Issue:4

    Topics: Animals; Bronchoalveolar Lavage Fluid; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytokines; Dinoprostone; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Enzymologic; Hydrochloric Acid; Isoenzymes; Macrophages, Alveolar; Male; Mice; Mice, Inbred C57BL; Nitrobenzenes; Peroxidases; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Up-Regulation

1998
Regulation of the cellular expression of secretory and cytosolic phospholipases A2, and cyclooxygenase-2 by peptide growth factors.
    Biochimica et biophysica acta, 1998, May-27, Volume: 1403, Issue:1

    Topics: Animals; Antineoplastic Agents; Becaplermin; Blotting, Western; Cells, Cultured; Cycloheximide; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Dinoprostone; Dose-Response Relationship, Drug; Epidermal Growth Factor; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Interferon-gamma; Interleukin-1; Isoenzymes; Nitrobenzenes; Osteoblasts; Phospholipases A; Platelet-Derived Growth Factor; Prostaglandin-Endoperoxide Synthases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-sis; Rats; Rats, Wistar; RNA, Messenger; Sulfonamides; Time Factors; Transcription, Genetic; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

1998
Vascular endothelial growth factor upregulates constitutive cyclooxygenase 1 in primary bovine and human endothelial cells.
    Life sciences, 1998, Volume: 62, Issue:24

    Topics: Animals; Blotting, Western; Cattle; Cell Division; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Endothelial Growth Factors; Endothelium, Vascular; Humans; Indomethacin; Isoenzymes; Lymphokines; Membrane Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

1998
Regulation of cyclooxygenase-2 expression in bovine chondrocytes in culture by interleukin 1alpha, tumor necrosis factor-alpha, glucocorticoids, and 17beta-estradiol.
    The Journal of rheumatology, 1998, Volume: 25, Issue:6

    Topics: Animals; Blotting, Northern; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytokines; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Estradiol; Gene Expression Regulation, Enzymologic; Interleukin-1; Isoenzymes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Recombinant Proteins; RNA, Messenger; Sulfonamides; Tumor Necrosis Factor-alpha

1998
Prostaglandin E2, interleukin 1alpha, and tumor necrosis factor-alpha increase human osteoclast formation and bone resorption in vitro.
    Endocrinology, 1998, Volume: 139, Issue:7

    Topics: Antibodies, Monoclonal; Bone Marrow Cells; Bone Resorption; Cell Count; Cell Division; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Humans; Indomethacin; Interleukin-1; Macrophage Colony-Stimulating Factor; Macrophages; Nitrobenzenes; Osteoclasts; Sulfonamides; Tumor Necrosis Factor-alpha

1998
Differing profiles of prostaglandin formation inhibition between selective prostaglandin H synthase-2 inhibitors and conventional NSAIDs in inflammatory and non-inflammatory sites of the rat.
    Prostaglandins & other lipid mediators, 1998, Volume: 55, Issue:5-6

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Gastric Juice; Indomethacin; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Pleurisy; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Sodium Chloride; Sulfonamides; Thromboxane B2

1998
Effects of the cyclooxygenase-2 inhibitor NS-398 on thromboxane and leukotriene synthesis in rat peritoneal cells.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1998, Volume: 47, Issue:5

    Topics: Animals; Cyclooxygenase Inhibitors; Dinoprostone; Indomethacin; Leukotriene B4; Leukotriene C4; Lipopolysaccharides; Nitrobenzenes; Peritoneal Cavity; Peritoneal Lavage; Rats; Rats, Sprague-Dawley; Sulfonamides; Thromboxane B2

1998
Induction of COX-2 expression by mechanical tension force in human periodontal ligament cells.
    Journal of periodontology, 1998, Volume: 69, Issue:6

    Topics: Alveolar Bone Loss; Anti-Inflammatory Agents, Non-Steroidal; Bite Force; Cell Nucleus; Cells, Cultured; Child; Culture Media; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dental Occlusion, Traumatic; Dinoprostone; Gene Expression Regulation, Enzymologic; Humans; Immunohistochemistry; Inflammation Mediators; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Periodontal Diseases; Periodontal Ligament; Peroxidases; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Stress, Mechanical; Sulfonamides; Surface Properties; Time Factors

1998
Regulation of macrophage eicosanoid generation is dependent on nuclear factor kappaB.
    The Journal of trauma, 1998, Volume: 45, Issue:1

    Topics: Animals; Cell Line; Cyclooxygenase Inhibitors; Dinoprostone; Escherichia coli; Gene Expression Regulation, Enzymologic; Ibuprofen; Lipopolysaccharides; Macrophages; Mice; Multiple Trauma; NF-kappa B; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Tosylphenylalanyl Chloromethyl Ketone; Transcriptional Activation

1998
Aspirin attenuates cytomegalovirus infectivity and gene expression mediated by cyclooxygenase-2 in coronary artery smooth muscle cells.
    Circulation research, 1998, Jul-27, Volume: 83, Issue:2

    Topics: Antiviral Agents; Aspirin; Cells, Cultured; Coronary Vessels; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytomegalovirus; Cytopathogenic Effect, Viral; Dexamethasone; Dinoprostone; Free Radical Scavengers; Gene Expression Regulation, Viral; Humans; Immediate-Early Proteins; Indomethacin; Isoenzymes; Membrane Proteins; Muscle Proteins; Muscle, Smooth, Vascular; NF-kappa B; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Reactive Oxygen Species; Sodium Salicylate; Sulfonamides; Transcriptional Activation; Viral Proteins; Virus Replication

1998
Cyclooxygenase-2 inhibitors suppress the growth of gastric cancer xenografts via induction of apoptosis in nude mice.
    The American journal of physiology, 1998, Volume: 274, Issue:6

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Apoptosis; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; Indomethacin; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron; Neoplasm Transplantation; Nitrobenzenes; Stomach Neoplasms; Sulfonamides; Transplantation, Heterologous; Tumor Cells, Cultured

1998
Impaired cAMP production in human airway smooth muscle cells by bradykinin: role of cyclooxygenase products.
    The American journal of physiology, 1998, Volume: 275, Issue:2

    Topics: Adult; Bradykinin; Calcimycin; Cells, Cultured; Cyclic AMP; Cycloheximide; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dactinomycin; Dexamethasone; Dinoprostone; Enzyme Induction; Female; Humans; Indomethacin; Isoenzymes; Isoproterenol; Male; Membrane Proteins; Middle Aged; Muscle, Smooth; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Receptor, Bradykinin B2; Receptors, Bradykinin; Sulfonamides; Trachea

1998
Cyclooxygenase-2 inhibitor NS-398 improves survival and restores leukocyte counts in burn infection.
    The Journal of trauma, 1998, Volume: 45, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Infections; Burns; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Drug Evaluation, Preclinical; Leukocyte Count; Macrophages, Peritoneal; Male; Mice; Mice, Inbred Strains; Nitrobenzenes; Random Allocation; Sulfonamides; Survival Analysis

1998
Role of cyclooxygenase-2 in the healing of gastric ulcers in rats.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:3

    Topics: Animals; Cyclooxygenase 2; Dinoprostone; Indomethacin; Isoenzymes; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; RNA, Messenger; Stomach Ulcer; Sulfonamides

1998
Effects of cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal antiinflammatory drugs on mucosal ulcerogenic and healing responses of the stomach.
    Digestive diseases and sciences, 1998, Volume: 43, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Mucosa; Hypothermia, Induced; Indomethacin; Isoenzymes; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Nitric Oxide; Nitrobenzenes; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stomach Ulcer; Sulfonamides; Wound Healing

1998
Cyclooxygenase 2 expression by endothelin-1-stimulated mouse resident peritoneal macrophages in vitro.
    European journal of pharmacology, 1998, Aug-28, Volume: 356, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Indomethacin; Isoenzymes; Macrophages, Peritoneal; Mice; Nitrobenzenes; Oligopeptides; Peptides, Cyclic; Piperidines; Prostaglandin-Endoperoxide Synthases; Sulfonamides

1998
Inflammation modifies the role of cyclooxygenases in the contractile responses of the rat detrusor smooth muscle to kinin agonists.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:1

    Topics: Animals; Bradykinin; Cystitis; Dinoprostone; In Vitro Techniques; Ketoprofen; Male; Muscle Contraction; Nitrobenzenes; Piroxicam; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Sulfonamides; Urinary Bladder

1998
Effects of novel anti-inflammatory compounds on healing of acetic acid-induced gastric ulcer in rats.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:1

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Mucosa; Indomethacin; Isoenzymes; Lipoxygenase Inhibitors; Male; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stomach Ulcer; Sulfonamides

1998
Effect of selective inhibition of cyclooxygenase 2 on temporary focal cerebral ischemia in rats.
    Neuroscience letters, 1998, Oct-30, Volume: 256, Issue:1

    Topics: Animals; Brain; Cerebral Infarction; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Injections, Intraperitoneal; Ischemic Attack, Transient; Isoenzymes; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Reperfusion; Sulfonamides

1998
Expression and vascular effects of cyclooxygenase-2 in brain.
    Stroke, 1998, Volume: 29, Issue:12

    Topics: Adenosine Diphosphate; Animals; Arterioles; Bradykinin; Brain; Cerebrovascular Circulation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Isoenzymes; Lipopolysaccharides; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfonamides; Vasodilation

1998
Prevention of NNK-induced lung tumorigenesis in A/J mice by acetylsalicylic acid and NS-398.
    Cancer research, 1998, Dec-01, Volume: 58, Issue:23

    Topics: Animals; Anticarcinogenic Agents; Aspirin; Biotransformation; Carcinogens; Cell Division; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Stability; Female; Hydroxylation; Isoenzymes; Lung Neoplasms; Membrane Proteins; Mice; Mice, Inbred A; Nitrobenzenes; Nitrosamines; Prostaglandin-Endoperoxide Synthases; Sulfonamides

1998
Role of cyclo-oxygenase-2 induction in interleukin-1beta induced attenuation of cultured human airway smooth muscle cell cyclic AMP generation in response to isoprenaline.
    British journal of pharmacology, 1998, Volume: 125, Issue:6

    Topics: Adrenergic beta-Agonists; Adult; Arachidonic Acid; Cell Survival; Cells, Cultured; Cyclic AMP; Cycloheximide; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dactinomycin; Dexamethasone; Dinoprostone; Enzyme Induction; Female; Glucocorticoids; Humans; Indomethacin; Interferon-gamma; Interleukin-1; Isoenzymes; Isoproterenol; Male; Membrane Proteins; Middle Aged; Muscle, Smooth; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein Synthesis Inhibitors; Sulfonamides; Trachea; Tumor Necrosis Factor-alpha

1998
Basic fibroblast growth factor induces cyclooxygenase-2 expression in endothelial cells derived from bone.
    Biochemical and biophysical research communications, 1999, Jan-08, Volume: 254, Issue:1

    Topics: Animals; Bone Marrow Cells; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Endothelium; Fibroblast Growth Factor 2; Isoenzymes; Mice; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides

1999
Anaphylaxis increases 8-iso-prostaglandin F2alpha release from guinea-pig lung in vitro.
    European journal of pharmacology, 1999, Jan-15, Volume: 365, Issue:1

    Topics: Anaphylaxis; Animals; Bronchoconstriction; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; F2-Isoprostanes; Guinea Pigs; In Vitro Techniques; Indomethacin; Lung; Male; Nitrobenzenes; Ovalbumin; Sulfonamides; Thromboxane B2

1999
Contribution of cyclooxygenase-1 and cyclooxygenase-2 to prostanoid formation by human enterocytes stimulated by calcium ionophore and inflammatory agents.
    Prostaglandins & other lipid mediators, 1998, Volume: 56, Issue:5-6

    Topics: Calcimycin; Calcium; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Eicosanoids; Epithelial Cells; Humans; Immunoblotting; Interleukin-1; Intestinal Mucosa; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Nitrobenzenes; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Salicylates; Sulfonamides; Tetradecanoylphorbol Acetate

1998
Cyclo-oxygenase-2 mediates P2Y receptor-induced reactive astrogliosis.
    British journal of pharmacology, 1999, Volume: 126, Issue:3

    Topics: Adenosine Triphosphate; Animals; Aspirin; Astrocytes; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Gliosis; Isoenzymes; Nitrobenzenes; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rats; Receptors, Purinergic P2; Sulfonamides; Time Factors

1999
Involvement of tyrosine kinases on cyclooxygenase expression and prostaglandin E2 production in human gingival fibroblasts stimulated with interleukin-1beta and epidermal growth factor.
    Biochemical and biophysical research communications, 1999, Apr-13, Volume: 257, Issue:2

    Topics: Benzoquinones; Cells, Cultured; Child; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Epidermal Growth Factor; Fibroblasts; Gene Expression Regulation; Gingiva; Humans; Interleukin-1; Isoenzymes; Lactams, Macrocyclic; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Quinazolines; Quinones; Rifabutin; RNA, Messenger; Sulfonamides; Time Factors

1999
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis.
    The Journal of clinical investigation, 1999, Volume: 103, Issue:9

    Topics: Animals; Antigens, CD; Arthritis, Rheumatoid; Bone Marrow Cells; Carrier Proteins; Cell Division; Coculture Techniques; Cyclooxygenase Inhibitors; Dinoprostone; Gene Expression Regulation; Humans; Indomethacin; Interleukin-17; Male; Membrane Glycoproteins; Mice; Nitrobenzenes; Osteoclasts; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Sulfonamides; Synovial Fluid

1999
Lack of beneficial effect of COX-2 inhibitors in an experimental model of colitis.
    Methods and findings in experimental and clinical pharmacology, 1999, Volume: 21, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Isoenzymes; Male; Nitrobenzenes; Peroxidase; Peroxidases; Phenols; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiazoles; Trinitrobenzenesulfonic Acid

1999
Synthetic pathways of gallbladder mucosal prostanoids: the role of cyclooxygenase-1 and 2.
    Prostaglandins, leukotrienes, and essential fatty acids, 1999, Volume: 60, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Blotting, Western; Cholecystitis; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Female; Gallbladder; Gallbladder Neoplasms; Humans; Isoenzymes; Lipopolysaccharides; Lysophosphatidylcholines; Male; Membrane Proteins; Middle Aged; Mucous Membrane; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Sulfonamides; Tumor Cells, Cultured

1999
Prostaglandin-endoperoxide H synthase-2 expression in human thyroid epithelium. Evidence for constitutive expression in vivo and in cultured KAT-50 cells.
    The Journal of biological chemistry, 1999, May-28, Volume: 274, Issue:22

    Topics: Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Down-Regulation; Gene Expression Regulation; Genes, Reporter; Humans; Immunohistochemistry; Interleukin-1; Isoenzymes; Membrane Proteins; Nitrobenzenes; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Receptors, Interleukin-1; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Thyroid Gland; Transfection

1999
Inducible cyclooxygenase may have anti-inflammatory properties.
    Nature medicine, 1999, Volume: 5, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Inflammation; Isoenzymes; Male; Membrane Proteins; Monocytes; Neutrophils; Nitrobenzenes; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfonamides

1999
Cyclooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen.
    Nature medicine, 1999, Volume: 5, Issue:8

    Topics: Animals; Arachidonic Acid; CD4-Positive T-Lymphocytes; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Immunity, Mucosal; Intestinal Mucosa; Intestine, Small; Isoenzymes; Leukocytes, Mononuclear; Macrophages; Mice; Mice, Transgenic; Muramidase; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Spleen; Sulfonamides

1999
Modulation by endothelin-1 of lipopolysaccharide-induced cyclooxygenase 2 expression in mouse peritoneal macrophages.
    European journal of pharmacology, 1999, Jul-09, Volume: 376, Issue:3

    Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Endothelin Receptor Antagonists; Endothelin-1; Isoenzymes; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Nitrobenzenes; Oligopeptides; Piperidines; Prostaglandin-Endoperoxide Synthases; Receptor, Endothelin B; Receptors, Endothelin; Sulfonamides; Vasoconstrictor Agents

1999
Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts.
    The Journal of experimental medicine, 1999, Aug-16, Volume: 190, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Arachidonic Acid; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Embryo, Mammalian; Fibroblasts; Ibuprofen; Indomethacin; Isoenzymes; Membrane Proteins; Mice; Mice, Knockout; Nitrobenzenes; Oncogene Proteins, Viral; Piroxicam; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins p21(ras); RNA, Messenger; Simian virus 40; Sulfonamides; Sulindac

1999
Cyclooxygenase-2 expression and function in the medullary thick ascending limb.
    The American journal of physiology, 1999, Volume: 277, Issue:3

    Topics: Animals; Carcinogens; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Isoenzymes; Loop of Henle; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

1999
Regulation of cyclooxygenase-2 expression by phosphatidate phosphohydrolase in human amnionic WISH cells.
    The Journal of biological chemistry, 1999, Sep-24, Volume: 274, Issue:39

    Topics: Amnion; Arachidonic Acid; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Ethanol; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Kinetics; Membrane Proteins; Naphthalenes; Nitrobenzenes; Pancreatitis-Associated Proteins; Phosphatidate Phosphatase; Phosphodiesterase Inhibitors; Propranolol; Prostaglandin-Endoperoxide Synthases; Pyrones; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic

1999
Bacterial lipopolysaccharide increases prostaglandin production by rat astrocytes via inducible cyclo-oxygenase: evidence for the involvement of nuclear factor kappaB.
    Biochemical and biophysical research communications, 1999, Sep-24, Volume: 263, Issue:2

    Topics: Animals; Animals, Newborn; Astrocytes; Cell Nucleus; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Ditiocarb; Escherichia coli; Gold Sodium Thiomalate; Hypothalamus; Isoenzymes; Lipopolysaccharides; NF-kappa B; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein Binding; Rats; Rats, Wistar; Response Elements; Sulfonamides

1999
The effect of selective cyclooxygenase-2 inhibitor on corneal angiogenesis in the rat.
    Current eye research, 1999, Volume: 19, Issue:4

    Topics: Administration, Topical; Animals; Cornea; Corneal Neovascularization; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Indomethacin; Isoenzymes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfonamides

1999
Effect of cyclooxygenase-2 inhibition on renal function after renal ablation.
    Hypertension (Dallas, Tex. : 1979), 1999, Volume: 34, Issue:4 Pt 2

    Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Indomethacin; Isoenzymes; Kidney Function Tests; Male; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Renal Insufficiency; Sulfonamides

1999
Prostaglandin E(2) mediates inhibition of insulin secretion by interleukin-1beta.
    The Journal of biological chemistry, 1999, Oct-29, Volume: 274, Issue:44

    Topics: Adenylyl Cyclases; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Glucose; Insulin; Insulin Secretion; Interleukin-1; Islets of Langerhans; Isoenzymes; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Sulfonamides

1999
NS-398 upregulates constitutive cyclooxygenase-2 expression in the M-1 cortical collecting duct cell line.
    Journal of the American Society of Nephrology : JASN, 1999, Volume: 10, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Isoenzymes; Kidney Cortex; Kidney Tubules, Collecting; Membrane Proteins; Mice; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides; Up-Regulation

1999
Natriuretic response to increased pressure is preserved with COX-2 inhibitors.
    Hypertension (Dallas, Tex. : 1979), 1999, Volume: 34, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Isoenzymes; Kidney; Male; Meloxicam; Natriuresis; Nitrobenzenes; Piroxicam; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiazines; Thiazoles

1999
Role of prostaglandins generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia-reperfusion-induced gastric lesions.
    European journal of pharmacology, 1999, Nov-26, Volume: 385, Issue:1

    Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Gastric Mucosa; Gastrins; Gene Expression Regulation, Enzymologic; Indomethacin; Interleukin-1; Isoenzymes; Lactones; Meloxicam; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Regional Blood Flow; Reperfusion Injury; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stilbenes; Stomach Ulcer; Sulfonamides; Sulfones; Thiazines; Thiazoles; Time Factors

1999
A cyclooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug enhances the growth inhibitory effect of butyrate in colorectal carcinoma cells expressing COX-2 protein: regulation of COX-2 by butyrate.
    Carcinogenesis, 2000, Volume: 21, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Butyrates; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Humans; Isoenzymes; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Sulfonamides; Transforming Growth Factor beta; Tumor Cells, Cultured; Up-Regulation

2000
Cyclooxygenase-2 expression in human pancreatic adenocarcinomas.
    Carcinogenesis, 2000, Volume: 21, Issue:2

    Topics: Adenocarcinoma; Animals; Cell Line, Transformed; Codon; Cricetinae; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Induction; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Indomethacin; Isoenzymes; Membrane Proteins; Mesocricetus; Neoplasm Proteins; Nitrobenzenes; Pancreas; Pancreatic Neoplasms; Point Mutation; Prostaglandin-Endoperoxide Synthases; Signal Transduction; Sulfonamides; Sulindac

2000
Role of COX-2 inhibition on the formation and healing of gastric ulcers induced by indomethacin in the rat.
    Advances in experimental medicine and biology, 1999, Volume: 469

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Indomethacin; Isoenzymes; Ketorolac; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach Ulcer; Sulfonamides; Time Factors; Wound Healing

1999
A comparison of the effects of indomethacin and NS-398 (a selective prostaglandin H synthase-2 inhibitor) on implantation in the rat.
    Prostaglandins, leukotrienes, and essential fatty acids, 1999, Volume: 61, Issue:5

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Embryo Implantation; Female; In Vitro Techniques; Indomethacin; Isoenzymes; Nitrobenzenes; Pregnancy; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfonamides; Uterus

1999
Inducible types of cyclooxygenase and nitric oxide synthase in adaptive cytoprotection in rat stomachs.
    Journal of physiology, Paris, 1999, Volume: 93, Issue:5

    Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cytoprotection; Dinoprostone; Enzyme Induction; Gastric Mucosa; Gastrointestinal Contents; Gene Expression Regulation, Enzymologic; Hydrochloric Acid; Indomethacin; Isoenzymes; Male; Membrane Proteins; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfonamides; Taurocholic Acid; Transcription, Genetic

1999
Roles of endogenous prostaglandins and nitric oxide in gastroduodenal ulcerogenic responses induced in rats by hypothermic stress.
    Journal of physiology, Paris, 1999, Volume: 93, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Aspirin; Atropine; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Acid; Gastric Mucosa; Hypothermia; Indomethacin; Intestinal Mucosa; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrobenzenes; Peptic Ulcer; Prostaglandins; Rats; Rats, Sprague-Dawley; Stress, Physiological; Sulfonamides; Vagotomy

1999
Sensitivity difference to the suppressive effect of prostaglandin E2 among mouse strains: a possible mechanism to polarize Th2 type response in BALB/c mice.
    Journal of immunology (Baltimore, Md. : 1950), 2000, Mar-01, Volume: 164, Issue:5

    Topics: Adjuvants, Immunologic; Animals; Antigen-Presenting Cells; Binding Sites; Cell Differentiation; Cells, Cultured; Cyclooxygenase 2; Cytokines; Dinoprostone; Immunity, Cellular; Immunosuppressive Agents; Injections, Intramuscular; Injections, Intraperitoneal; Interferon-gamma; Interleukin-10; Isoenzymes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Nitric Oxide; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Spleen; Sulfonamides; Th1 Cells; Th2 Cells

2000
Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2.
    The Journal of clinical investigation, 2000, Volume: 105, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dextrans; Dinoprostone; Interleukin-1; Intestinal Mucosa; Isoenzymes; Membrane Proteins; Mice; Mice, Mutant Strains; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfates; Sulfonamides

2000
Effective diminution of amniotic prostaglandin production by selective inhibitors of cyclooxygenase type 2.
    American journal of obstetrics and gynecology, 2000, Volume: 182, Issue:2

    Topics: Amnion; Blotting, Western; Chorion; Cyclooxygenase Inhibitors; Decidua; Dinoprostone; Electrophoresis, Polyacrylamide Gel; Female; Gene Expression Regulation; Humans; Immunoenzyme Techniques; Indomethacin; Isoenzymes; Labor, Obstetric; Myometrium; Nitrobenzenes; Pregnancy; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Tocolytic Agents

2000
Endogenous prostaglandin formation in the field-stimulated guinea-pig vas deferens: comparison of the inhibitory effects of indomethacin and NS-398.
    Prostaglandins, leukotrienes, and essential fatty acids, 1999, Volume: 61, Issue:6

    Topics: Animals; Arachidonic Acid; Cyclooxygenase Inhibitors; Dinoprostone; Electric Stimulation; Guinea Pigs; Indomethacin; Isoenzymes; Male; Muscle Contraction; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfonamides; Vas Deferens

1999
Inhibition of cyclooxygenase-2 decreases DNA synthesis induced by platelet-derived growth factor in Swiss 3T3 fibroblasts.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 293, Issue:2

    Topics: 3T3 Cells; Animals; Blotting, Western; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; DNA; Fibroblasts; Isoenzymes; Mice; Nitrobenzenes; Platelet-Derived Growth Factor; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thymidine

2000
Bradykinin potentiates prostaglandin E(2) release in the human gingival fibroblasts pretreated with interleukin-1beta via Ca(2+) mobilization.
    European journal of pharmacology, 2000, May-03, Volume: 395, Issue:3

    Topics: Bradykinin; Calcium; Cells, Cultured; Cycloheximide; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dactinomycin; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Fibroblasts; Gingiva; Humans; Interleukin-1; Ionomycin; Ionophores; Isoenzymes; Membrane Proteins; Nitrobenzenes; Nucleic Acid Synthesis Inhibitors; Prostaglandin-Endoperoxide Synthases; Protein Synthesis Inhibitors; Sulfonamides; Time Factors

2000
Prostaglandin E(2) increases bovine leukemia virus tax and pol mRNA levels via cyclooxygenase 2: regulation by interleukin-2, interleukin-10, and bovine leukemia virus.
    Journal of virology, 2000, Volume: 74, Issue:12

    Topics: Animals; Autocrine Communication; Cattle; Cell Division; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gene Expression Regulation, Viral; Gene Products, pol; Gene Products, tax; Interleukin-10; Interleukin-2; Isoenzymes; Leukemia Virus, Bovine; Leukocytes, Mononuclear; Lymphocyte Activation; Models, Biological; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; RNA, Viral; Sulfonamides

2000
Lipopolysaccharide is radioprotective in the mouse intestine through a prostaglandin-mediated mechanism.
    Gastroenterology, 2000, Volume: 118, Issue:6

    Topics: Animals; Blotting, Western; Body Temperature; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Epithelial Cells; Female; Genotype; Indomethacin; Intestine, Small; Isoenzymes; Lipopolysaccharides; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Radiation Injuries, Experimental; Radiation-Protective Agents; Sulfonamides

2000
Cyclooxygenase-2 inhibitors constrict the fetal lamb ductus arteriosus both in vitro and in vivo.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 278, Issue:6

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Ductus Arteriosus; Epoprostenol; Female; Hemodynamics; In Vitro Techniques; Indomethacin; Isoenzymes; Nitrobenzenes; Nitroprusside; Oxygen; Pregnancy; Prostaglandin-Endoperoxide Synthases; Pulmonary Artery; Pyrazoles; Sheep; Sulfonamides; Vasoconstriction; Vasodilator Agents

2000
COX-2 inhibition prevents insulin-dependent diabetes in low-dose streptozotocin-treated mice.
    Biochemical and biophysical research communications, 2000, Jul-05, Volume: 273, Issue:2

    Topics: Animals; Blood Glucose; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dinoprostone; Glycated Hemoglobin; Indomethacin; Isoenzymes; Male; Mice; Mice, Inbred BALB C; Nitrobenzenes; Pancreas; Prostaglandin-Endoperoxide Synthases; Streptozocin; Sulfonamides; Time Factors

2000
Upregulation of vascular endothelial growth factor by cobalt chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human prostate cancer cell line.
    Clinical & experimental metastasis, 1999, Volume: 17, Issue:8

    Topics: Androgens; Cell Hypoxia; Cobalt; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Interactions; Endothelial Growth Factors; Enzyme Induction; Humans; Isoenzymes; Lymphokines; Male; Membrane Proteins; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostatic Neoplasms; Stimulation, Chemical; Sulfonamides; Tumor Cells, Cultured; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

1999
Phorbol ester stimulates cyclooxygenase-2 expression and prostanoid production in cardiac myocytes.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:2

    Topics: Animals; Animals, Newborn; Cell Division; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Gene Expression Regulation, Enzymologic; Indomethacin; Interleukin-1; Isoenzymes; Leucine; Mitogen-Activated Protein Kinases; Myocardium; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetradecanoylphorbol Acetate

2000
MAPK mediation of hypertonicity-stimulated cyclooxygenase-2 expression in renal medullary collecting duct cells.
    The Journal of biological chemistry, 2000, Jul-28, Volume: 275, Issue:30

    Topics: Animals; Cell Line; Cyclooxygenase 2; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Kidney Tubules, Collecting; Mice; Mitogen-Activated Protein Kinases; Nitrobenzenes; Osmolar Concentration; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Sulfonamides

2000
Growth differentiation factor-9 stimulates progesterone synthesis in granulosa cells via a prostaglandin E2/EP2 receptor pathway.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Aug-29, Volume: 97, Issue:18

    Topics: Alprostadil; Animals; Bone Morphogenetic Protein 15; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Female; Granulosa Cells; Growth Differentiation Factor 9; Growth Substances; Indomethacin; Intercellular Signaling Peptides and Proteins; Isoenzymes; Kinetics; Male; Mice; Mice, Inbred ICR; Models, Biological; Nitrobenzenes; Progesterone; Prostaglandin-Endoperoxide Synthases; Prostaglandins E, Synthetic; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Transcription, Genetic

2000
Chronic cyclooxygenase-2 inhibition blunts low sodium-stimulated renin without changing renal haemodynamics.
    Journal of hypertension, 2000, Volume: 18, Issue:8

    Topics: Animals; Blood Pressure; Cyclic GMP; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Hemodynamics; Isoenzymes; Kidney; Male; Membrane Proteins; Nitrites; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Renal Circulation; Renin; Sodium; Sulfonamides

2000
Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases.
    Cancer research, 2000, Aug-15, Volume: 60, Issue:16

    Topics: 3T3 Cells; Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cell Movement; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Eicosanoids; Enzyme Inhibitors; Humans; Ibuprofen; Isoenzymes; Lipoxygenase; Lipoxygenase Inhibitors; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Membrane Proteins; Mice; Neoplasm Invasiveness; Nitrobenzenes; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Prostatic Neoplasms; Sulfonamides; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured; Umbelliferones

2000
Radiation induces upregulation of cyclooxygenase-2 (COX-2) protein in PC-3 cells.
    International journal of radiation oncology, biology, physics, 2000, Sep-01, Volume: 48, Issue:2

    Topics: Apoptosis; Biomarkers; Blotting, Western; Cell Cycle; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Activation; Gamma Rays; Humans; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Time Factors; Tumor Cells, Cultured; Up-Regulation

2000
Endotoxin augments cerebral hyperemic response to halothane by inducing nitric oxide synthase and cyclooxygenase.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:4

    Topics: Anesthetics, Inhalation; Animals; Arginine; Cerebrovascular Circulation; Citrulline; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Endotoxins; Enzyme Inhibitors; Escherichia coli; Guanidines; Halothane; Hydrazines; Hyperemia; Isoenzymes; Laser-Doppler Flowmetry; Lipopolysaccharides; Male; Nitric Oxide Donors; Nitric Oxide Synthase; Nitrobenzenes; Nitrogen Oxides; Peroxidases; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Respiration, Artificial; Sulfonamides

2000
Role of cyclooxygenase-2 in Helicobacter pylori- induced gastritis in Mongolian gerbils.
    American journal of physiology. Gastrointestinal and liver physiology, 2000, Volume: 279, Issue:4

    Topics: Animals; Chemokines; Chemotactic Factors; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Mucosa; Gastritis; Gastrointestinal Hemorrhage; Gerbillinae; Growth Inhibitors; Growth Substances; Helicobacter Infections; Helicobacter pylori; Indomethacin; Interferon-gamma; Interleukin-10; Isoenzymes; Male; Neutrophils; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides

2000
Eicosanoids as endogenous regulators of leptin release and lipolysis by mouse adipose tissue in primary culture.
    Journal of lipid research, 2000, Volume: 41, Issue:10

    Topics: Adenine; Adipose Tissue; Animals; Biological Transport; Cell Culture Techniques; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Eicosanoids; Leptin; Lipolysis; Mice; Mice, Inbred C57BL; Nitrobenzenes; RNA, Messenger; Sulfonamides

2000
Blocking prostaglandin E2 after trauma attenuates pro-inflammatory cytokines and improves survival.
    Shock (Augusta, Ga.), 2000, Volume: 14, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytokines; Dinoprostone; Female; Inflammation; Isoenzymes; Macrophages; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitrobenzenes; Organ Size; Prostaglandin-Endoperoxide Synthases; Sepsis; Spleen; Sulfonamides; Survival Rate; Wounds and Injuries

2000
Nonsteroidal anti-inflammatory drug-induced acute gastric injury in Helicobacter pylori gastritis in Mongolian gerbils.
    European journal of pharmacology, 2000, Oct-20, Volume: 406, Issue:3

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Dinoprostone; Gastric Mucosa; Gastritis; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Indomethacin; Isoenzymes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides

2000
Induction of cyclooxygenase-2 in rat gastric mucosa by rebamipide, a mucoprotective agent.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:2

    Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Gastric Mucosa; Hydrochloric Acid; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Quinolones; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Sulfonamides; Up-Regulation

2000
Cyclooxygenase-2-mediated angiogenesis in carrageenin-induced granulation tissue in rats.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Growth Factors; Granulation Tissue; Indomethacin; Inflammation; Isoenzymes; Leukocytes; Lymphokines; Male; Membrane Proteins; Neovascularization, Physiologic; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfonamides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2000
Regulation of leptin release and lipolysis by PGE2 in rat adipose tissue.
    Prostaglandins & other lipid mediators, 2000, Volume: 62, Issue:4

    Topics: Adenosine; Adipose Tissue; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Homeostasis; Isoenzymes; Leptin; Lipolysis; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfonamides

2000
Prostaglandins regulate melanoma-induced cytokine production in macrophages.
    Cellular immunology, 2000, Sep-15, Volume: 204, Issue:2

    Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Culture Media, Conditioned; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytokines; Dinoprostone; Female; Humans; Interleukin-6; Isoenzymes; Macrophages; Macrophages, Peritoneal; Melanoma, Experimental; Membrane Proteins; Mice; Mice, Inbred C57BL; Monocytes; NF-kappa B; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfonamides; Tumor Necrosis Factor-alpha

2000
Meloxicam inhibits prostaglandin E(2) generation via cyclooxygenase 2 in the inflammatory site but not that via cyclooxygenase 1 in the stomach.
    Pharmacology, 2000, Volume: 61, Issue:4

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Juice; Isoenzymes; Male; Meloxicam; Membrane Proteins; Nitrobenzenes; Pleura; Pleurisy; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach; Sulfonamides; Thiazines; Thiazoles

2000
Induction of p27(KIP1) as a mechanism underlying NS398-induced growth inhibition in human lung cancer cells.
    Molecular pharmacology, 2000, Volume: 58, Issue:6

    Topics: Antineoplastic Agents; Cell Cycle Proteins; Cell Division; Cyclin G; Cyclin G1; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; G1 Phase; Gene Expression Regulation; Humans; Isoenzymes; Lung Neoplasms; Membrane Proteins; Microtubule-Associated Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein Biosynthesis; Sulfonamides; Tumor Cells, Cultured; Tumor Suppressor Proteins; Up-Regulation

2000
Cyclooxygenase-2 expression in lipopolysaccharide-stimulated human monocytes is modulated by cyclic AMP, prostaglandin E(2), and nonsteroidal anti-inflammatory drugs.
    Biochemical and biophysical research communications, 2000, Nov-30, Volume: 278, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Bucladesine; Cells, Cultured; Cyclic AMP; Cyclooxygenase 1; Cyclooxygenase 2; Dexamethasone; Dinoprostone; Flurbiprofen; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Monocytes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Transcription, Genetic

2000
Interleukin-1beta induces the expression of insulin-like growth factor binding protein-1 during decidualization in the primate.
    Endocrinology, 2000, Volume: 141, Issue:12

    Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Decidua; Dinoprostone; Enzyme Activation; Estradiol; Female; Fibroblasts; Gene Expression; Humans; Insulin-Like Growth Factor Binding Protein 1; Interleukin-1; Isoenzymes; Medroxyprogesterone Acetate; Membrane Proteins; Mitogen-Activated Protein Kinases; NF-kappa B; Nitrobenzenes; Papio; Phosphorylation; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Stromal Cells; Sulfonamides

2000
IGF-II/IGF-I receptor pathway up-regulates COX-2 mRNA expression and PGE2 synthesis in Caco-2 human colon carcinoma cells.
    Oncogene, 2000, Nov-16, Volume: 19, Issue:48

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Apoptosis; Caco-2 Cells; Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Progression; Humans; Insulin-Like Growth Factor II; Isoenzymes; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Nitrobenzenes; Phosphoinositide-3 Kinase Inhibitors; Prostaglandin-Endoperoxide Synthases; Receptor, IGF Type 1; RNA, Messenger; Signal Transduction; Sulfonamides; Transfection; Up-Regulation

2000
Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 production.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2001, Volume: 30, Issue:1

    Topics: Carcinoma, Squamous Cell; Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Isoenzymes; Membrane Proteins; Nitrobenzenes; Oligonucleotides, Antisense; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Tongue Neoplasms; Tumor Cells, Cultured

2001
Gastroprotective and ulcer healing effects of nitric oxide-releasing non-steroidal anti-inflammatory drugs.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2000, Volume: 32, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Ethanol; Gastric Mucosa; Isoenzymes; Male; Membrane Proteins; Microcirculation; Models, Animal; Naproxen; Nitric Oxide; Nitrobenzenes; Nitroso Compounds; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Stomach; Stomach Ulcer; Sulfonamides

2000
Prostaglandin H synthase-2 inhibitors interfere with prostaglandin H synthase-1 inhibition by nonsteroidal anti-inflammatory drugs.
    European journal of pharmacology, 2001, Jan-19, Volume: 412, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Cattle; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Ibuprofen; Indomethacin; Isoenzymes; Male; Microsomes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sulfonamides; Thiophenes

2001
Dose-dependent modulation of apoptosis and cyclooxygenase-2 expression in human 1547 osteosarcoma cells by NS-398, a selective cyclooxygenase-2 inhibitor.
    International journal of oncology, 2001, Volume: 18, Issue:3

    Topics: Adenovirus E1A Proteins; Apoptosis; Arachidonic Acid; bcl-2-Associated X Protein; Blotting, Western; Bone Neoplasms; Cell Cycle; Cell Division; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; DNA Primers; Dose-Response Relationship, Drug; Humans; Indoles; Isoenzymes; Membrane Proteins; Nitrobenzenes; Osteosarcoma; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Tumor Cells, Cultured

2001
Involvement of cyclooxygenase (COX)-2 products in acceleration of ulcer healing by gastrin and hepatocyte growth factor.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2000, Volume: 51, Issue:4 Pt 1

    Topics: Animals; Antibodies; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Gastric Mucosa; Gastrins; Hepatocyte Growth Factor; Indomethacin; Isoenzymes; Lactones; Male; Membrane Proteins; Nitrobenzenes; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Sulfones

2000
Mechanisms of cholera toxin-induced diarrhea.
    Annals of the New York Academy of Sciences, 2000, Volume: 915

    Topics: Animals; Cholera Toxin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Diarrhea; Dinoprostone; Dose-Response Relationship, Drug; Furans; Gene Expression Regulation, Enzymologic; Glucocorticoids; Intestinal Mucosa; Isoenzymes; Jejunum; Lipopolysaccharides; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; RNA, Messenger; Sulfonamides

2000
Expression of cyclooxygenase 2 in human malignant melanoma.
    Cancer research, 2001, Jan-01, Volume: 61, Issue:1

    Topics: Biocompatible Materials; Cell Division; Collagen; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Combinations; Humans; Isoenzymes; Laminin; Melanoma; Membrane Proteins; Neoplasm Invasiveness; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Proteoglycans; RNA, Messenger; Sulfonamides; Tumor Cells, Cultured

2001
Assay of cyclooxygenase-1 and 2 in human monocytes.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2000, Volume: 49, Issue:12

    Topics: Aspirin; Blotting, Western; Cell Separation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Eicosanoids; Humans; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Monocytes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Thromboxane B2

2000
Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2.
    The Journal of experimental medicine, 2001, Mar-05, Volume: 193, Issue:5

    Topics: Angiogenesis Inhibitors; Animals; Cell Migration Inhibition; Cell Movement; Cells, Cultured; Cornea; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cyclosporine; Dinoprostone; DNA-Binding Proteins; Endothelial Growth Factors; Endothelium, Vascular; Gene Expression Regulation; Genes, Reporter; Humans; Isoenzymes; Lymphokines; Membrane Proteins; Mice; Mice, Inbred C57BL; Mutagenesis, Site-Directed; Neovascularization, Physiologic; NFATC Transcription Factors; Nitrobenzenes; Nuclear Proteins; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Transcription Factors; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2001
Differential effects of ethanol on the expression of cyclo-oxygenase in cultured cortical astrocytes and neurons.
    Journal of neurochemistry, 2001, Volume: 76, Issue:5

    Topics: Animals; Animals, Newborn; Arachidonic Acid; Astrocytes; Cells, Cultured; Cerebral Cortex; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Ethanol; Indomethacin; Isoenzymes; Kinetics; Membrane Proteins; Neurons; Nitrobenzenes; Phospholipases A; Prostaglandin-Endoperoxide Synthases; Rats; Sulfonamides

2001
Both cyclooxygenase-1 and cyclooxygenase-2 mediate osteoblast response to titanium surface roughness.
    Journal of biomedical materials research, 2001, Jun-05, Volume: 55, Issue:3

    Topics: Alkaline Phosphatase; Biocompatible Materials; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Indomethacin; Isoenzymes; Materials Testing; Membrane Proteins; Nitrobenzenes; Osteoblasts; Osteocalcin; Phenotype; Prostaglandin-Endoperoxide Synthases; Resveratrol; Stilbenes; Sulfonamides; Surface Properties; Titanium; Transforming Growth Factor beta

2001
Upregulated cyclooxygenase-2 inhibits apoptosis of human gastric epithelial cells infected with Helicobacter pylori.
    Digestive diseases and sciences, 2000, Volume: 45, Issue:12

    Topics: Apoptosis; Cell Line; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Epithelial Cells; Gene Expression Regulation, Bacterial; Helicobacter Infections; Helicobacter pylori; Humans; Isoenzymes; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Stomach; Sulfonamides; Up-Regulation

2000
Differential regulation of interleukin-1 beta-induced cyclooxygenase-2 gene expression by nimesulide in human synovial fibroblasts.
    Clinical and experimental rheumatology, 2001, Volume: 19, Issue:1 Suppl 22

    Topics: Arthritis, Rheumatoid; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Naproxen; Nitrobenzenes; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides; Synovial Membrane

2001
Nuclear factor-kappaB regulates cyclooxygenase-2 expression and cell proliferation in human gastric cancer cells.
    Laboratory investigation; a journal of technical methods and pathology, 2001, Volume: 81, Issue:3

    Topics: 6-Ketoprostaglandin F1 alpha; Adenocarcinoma; Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; I-kappa B Proteins; Isoenzymes; Membrane Proteins; Mutagenesis; NF-kappa B; NF-KappaB Inhibitor alpha; Nitrobenzenes; Oligonucleotides, Antisense; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Stomach Neoplasms; Sulfonamides; Thromboxane B2; Transfection; Tumor Cells, Cultured

2001
Involvement of cyclooxygenase-derived prostaglandin E2 and nitric oxide in the protection of rat pancreas afforded by low dose of lipopolysaccharide.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2001, Volume: 52, Issue:1

    Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ceruletide; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Indomethacin; Isoenzymes; Lactones; Lipopolysaccharides; Male; Membrane Proteins; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nitrobenzenes; Organ Size; Pancreas; Pancreatitis; Penicillamine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Resveratrol; S-Nitroso-N-Acetylpenicillamine; Stilbenes; Sulfonamides; Sulfones

2001
Inhibition of COX in ocular tissues: an in vitro model to identify selective COX-2 inhibitors.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2001, Volume: 17, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Endothelium, Corneal; Isoenzymes; Lipopolysaccharides; Nitrobenzenes; Pigment Epithelium of Eye; Piroxicam; Prostaglandin-Endoperoxide Synthases; Salmonella typhimurium; Sulfonamides

2001
Involvement of cyclooxygenase-2 in serum-induced prostaglandin production by human oral gingival epithelial cells.
    Journal of periodontal research, 2001, Volume: 36, Issue:2

    Topics: Analysis of Variance; Blood; Blotting, Western; Cells, Cultured; Culture Media; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Epithelial Cells; Gene Expression; Gingiva; Humans; Indomethacin; Inflammation Mediators; Interleukin-1; Isoenzymes; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Statistics as Topic; Sulfonamides; Time Factors; Tumor Necrosis Factor-alpha

2001
Reduction of pathological and behavioral deficits following spinal cord contusion injury with the selective cyclooxygenase-2 inhibitor NS-398.
    Journal of neurotrauma, 2001, Volume: 18, Issue:4

    Topics: Animals; Behavior, Animal; Contusions; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Hot Temperature; Hypesthesia; Immunohistochemistry; Isoenzymes; Male; Motor Activity; Nitrobenzenes; Physical Stimulation; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Sulfonamides

2001
Cyclooxygenase-2 is upregulated in inflamed gingival tissues.
    Journal of periodontology, 2001, Volume: 72, Issue:4

    Topics: Aggregatibacter actinomycetemcomitans; Bacteroides; Biopsy; Blotting, Western; Cells, Cultured; Coloring Agents; Connective Tissue Cells; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cyclosporine; Dinoprostone; Endothelium; Enzyme Inhibitors; Eosine Yellowish-(YS); Epithelium; Fibroblasts; Fluorescent Dyes; Gene Expression; Gingiva; Gingivitis; Hematoxylin; Humans; Interleukin-1; Isoenzymes; Membrane Proteins; Nitrobenzenes; Peroxidases; Prostaglandin-Endoperoxide Synthases; Statistics as Topic; Statistics, Nonparametric; Sulfonamides; Up-Regulation

2001
Stimulative effect of cadmium on prostaglandin E2 production in primary mouse osteoblastic cells.
    Calcified tissue international, 2001, Volume: 68, Issue:3

    Topics: Animals; Animals, Newborn; Arachidonic Acid; Arachidonic Acids; Cadmium; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Interleukin-1; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred Strains; Nitrobenzenes; Osteoblasts; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides

2001
Cholera toxin induces prostaglandin synthesis via post-transcriptional activation of cyclooxygenase-2 in the rat jejunum.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:3

    Topics: Animals; Blotting, Western; Cholera Toxin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Female; Furans; Glucocorticoids; Intestinal Mucosa; Isoenzymes; Jejunum; Lipopolysaccharides; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein Processing, Post-Translational; Pyrazoles; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides

2001
Tumor necrosis factor-alpha induces cyclooxygenase-2 expression and prostaglandin release in brain microvessel endothelial cells.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:3

    Topics: Animals; Blood-Brain Barrier; Blotting, Western; Brain; Cattle; Cell Membrane Permeability; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytoskeleton; Dinoprost; Dinoprostone; Endothelium, Vascular; Indomethacin; Isoenzymes; Microcirculation; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfonamides; Tumor Necrosis Factor-alpha

2001
Adaptive gastric cytoprotection is mediated by prostaglandin EP1 receptors: a study using rats and knockout mice.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:3

    Topics: Adaptation, Physiological; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cytoprotection; Dinoprostone; Dose-Response Relationship, Drug; Ethanol; Gastric Mucosa; Hydrochloric Acid; Indomethacin; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Stomach Ulcer; Sulfonamides; Taurocholic Acid

2001
NS-398 treatment after trauma modifies NF-kappaB activation and improves survival.
    The Journal of surgical research, 2001, Jun-01, Volume: 98, Issue:1

    Topics: Animals; Bacterial Infections; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Female; Femoral Fractures; Interleukin-6; Isoenzymes; Leukotriene B4; Macrophages; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Spleen; Sulfonamides; Survival Analysis; Tumor Necrosis Factor-alpha; Wounds and Injuries

2001
Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers.
    Microscopy research and technique, 2001, Jun-01, Volume: 53, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Mucosa; Gastrins; Indomethacin; Interleukin-1; Isoenzymes; Lactones; Male; Meloxicam; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Rats; Rats, Wistar; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stilbenes; Stomach Ulcer; Sulfonamides; Sulfones; Thiazines; Thiazoles; Tumor Necrosis Factor-alpha

2001
Effect of COX-2 inhibitor NS-398 on expression of PGE2 receptor subtypes in M-1 mouse CCD cells.
    American journal of physiology. Renal physiology, 2001, Volume: 281, Issue:1

    Topics: Animals; Blotting, Western; Cell Line; Cyclic AMP; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Gene Expression Regulation; Isoenzymes; Kidney Tubules, Collecting; Mice; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein Isoforms; Receptors, Prostaglandin E; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides

2001
COX-2 expression and cell cycle progression in human fibroblasts.
    American journal of physiology. Cell physiology, 2001, Volume: 281, Issue:1

    Topics: Apoptosis; Aspirin; Cell Cycle; Cells, Cultured; Culture Media, Serum-Free; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Fibroblasts; Humans; Indomethacin; Interleukin-1; Isoenzymes; Membrane Proteins; Nitrobenzenes; Platelet-Derived Growth Factor; Prostaglandin-Endoperoxide Synthases; Protein Isoforms; Sulfonamides

2001
Induction of apoptosis by cyclo-oxygenase-2 inhibitor NS398 through a cytochrome C-dependent pathway in esophageal cancer cells.
    International journal of cancer, 2001, Jul-15, Volume: 93, Issue:2

    Topics: Apoptosis; Caspase Inhibitors; Caspases; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytochrome c Group; Dinoprostone; Drug Interactions; Enzyme Activation; Esophageal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Isoenzymes; Membrane Proteins; Mitochondria; Nitrobenzenes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Prostaglandin-Endoperoxide Synthases; Proteins; Sulfonamides; Tumor Cells, Cultured

2001
Dendritic cells issued in vitro from bone marrow produce PGE(2) that contributes to the immunomodulation induced by antigen-presenting cells.
    Cellular immunology, 2001, Apr-10, Volume: 209, Issue:1

    Topics: Adjuvants, Immunologic; Animals; Antigen-Presenting Cells; Bone Marrow Cells; Cell Lineage; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dendritic Cells; Dinoprostone; Female; Indomethacin; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred BALB C; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides

2001
Role of prostaglandins in the suppression of apoptosis in hen granulosa cells by transforming growth factor alpha.
    Reproduction (Cambridge, England), 2001, Volume: 122, Issue:1

    Topics: Alprostadil; Animals; Apoptosis; Arachidonic Acid; Arachidonic Acids; Aristolochic Acids; Cells, Cultured; Chickens; Chromatin; Culture Media, Serum-Free; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; DNA Fragmentation; Enzyme Inhibitors; Female; Granulosa Cells; Ibuprofen; Nitrobenzenes; Phenanthrenes; Phospholipases A; Prostaglandins; Prostaglandins E; Prostaglandins F; Sulfonamides; Transforming Growth Factor alpha

2001
Obesity is induced in mice heterozygous for cyclooxygenase-2.
    Prostaglandins & other lipid mediators, 2001, Volume: 65, Issue:4

    Topics: 6-Ketoprostaglandin F1 alpha; Adipose Tissue; Animals; Body Weight; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Epididymis; Female; Heterozygote; Humans; Isoenzymes; Leptin; Male; Membrane Proteins; Mice; Mice, Knockout; Nitrobenzenes; Obesity; Organ Size; Prostaglandin-Endoperoxide Synthases; Statistics as Topic; Sulfonamides

2001
Effects of nonsteroidal anti-inflammatory drugs on Helicobacter pylori-infected gastric mucosae of mice: apoptosis, cell proliferation, and inflammatory activity.
    Infection and immunity, 2001, Volume: 69, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Division; Chronic Disease; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Epithelial Cells; Female; Gastric Mucosa; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Indomethacin; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred C57BL; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides

2001
Modulation of haem oxygenase-1 expression by nitric oxide and leukotrienes in zymosan-activated macrophages.
    British journal of pharmacology, 2001, Volume: 133, Issue:6

    Topics: Amidines; Animals; Benzylamines; Cell Line; Chick Embryo; Cyclooxygenase 2; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Eicosanoids; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hydroxyurea; Indomethacin; Isoenzymes; Leukotriene B4; Leukotriene C4; Leukotrienes; Macrophage Activation; Macrophages; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein Binding; Pyrans; Quinolones; Sulfonamides; Time Factors; Transcription Factor AP-1; Zymosan

2001
Effects of 1alpha,25-(OH)(2)D(3) on rat growth zone chondrocytes are mediated via cyclooxygenase-1 and phospholipase A(2).
    Journal of cellular biochemistry. Supplement, 2001, Volume: Suppl 36

    Topics: Alkaline Phosphatase; Animals; Arachidonic Acid; Blotting, Northern; Calcitriol; Cells, Cultured; Chondrocytes; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Growth Plate; Indomethacin; Isoenzymes; Lipoxygenase; Lipoxygenase Inhibitors; Masoprocol; Membrane Proteins; Nitrobenzenes; Phospholipases A; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Proteoglycans; Rats; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; Stilbenes; Sulfonamides; Thymidine; Umbelliferones

2001
Enhanced cyclooxygenase-2 mRNA expression in human gingival fibroblasts induced by cell contact with human lymphocytes.
    European journal of oral sciences, 2001, Volume: 109, Issue:3

    Topics: Cell Communication; Cell Count; Cell Culture Techniques; Coculture Techniques; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Fibroblasts; Gene Expression Regulation, Enzymologic; Gingiva; Humans; Isoenzymes; Lymphocytes; Membrane Proteins; Nitrobenzenes; Periodontal Diseases; Peroxidases; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Statistics as Topic; Sulfonamides; Up-Regulation

2001
Stimulation of leptin release by arachidonic acid and prostaglandin E(2) in adipose tissue from obese humans.
    Metabolism: clinical and experimental, 2001, Volume: 50, Issue:8

    Topics: Adipose Tissue; Adult; Arachidonic Acid; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Enzyme Induction; Humans; In Vitro Techniques; Isoenzymes; Leptin; Male; Membrane Proteins; Nitrobenzenes; Obesity; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides; Up-Regulation

2001
Cyclooxygenase inhibitors retard murine mammary tumor progression by reducing tumor cell migration, invasiveness and angiogenesis.
    International journal of cancer, 2001, Aug-15, Volume: 93, Issue:4

    Topics: Animals; Cell Division; Cell Movement; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Female; Indomethacin; Isoenzymes; Mammary Neoplasms, Experimental; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Membrane Proteins; Mice; Mice, Inbred C3H; Neovascularization, Pathologic; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides

2001
Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer.
    International journal of cancer, 2001, Sep-01, Volume: 93, Issue:5

    Topics: Animals; Breast Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Female; Indomethacin; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasm Transplantation; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Tumor Cells, Cultured

2001
Platelet activating factor increases ciliary activity in the hamster oviduct through epithelial production of prostaglandin E2.
    Pflugers Archiv : European journal of physiology, 2001, Volume: 442, Issue:3

    Topics: Animals; Arachidonic Acids; Calcium; Cells, Cultured; Cilia; Cricetinae; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Epithelial Cells; Female; Immunohistochemistry; Isoenzymes; Mesocricetus; Nitrobenzenes; Oviducts; Oxytocics; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Signal Transduction; Sulfonamides

2001
Prostaglandin E2 receptors EP2 and EP4 are down-regulated in human mononuclear cells after injury.
    Surgery, 2001, Volume: 130, Issue:2

    Topics: Adult; Aged; Burns; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Down-Regulation; Female; Fractures, Bone; Gene Expression; Humans; In Vitro Techniques; Isoenzymes; Leukocytes, Mononuclear; Leukotriene B4; Lipopolysaccharide Receptors; Lipopolysaccharides; Male; Membrane Proteins; Middle Aged; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; RNA, Messenger; Signal Transduction; Sulfonamides; Tumor Necrosis Factor-alpha

2001
Selective inhibition of COX-2 improves early survival in murine endotoxemia but not in bacterial peritonitis.
    American journal of physiology. Lung cellular and molecular physiology, 2001, Volume: 281, Issue:3

    Topics: Animals; Bacterial Infections; Body Temperature Regulation; Cecum; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytokines; Dinoprostone; Endotoxemia; Isoenzymes; Ligation; Lipopolysaccharides; Lung; Mice; Mice, Inbred Strains; Motor Activity; Neutrophils; Nitrobenzenes; Peritonitis; Prostaglandin-Endoperoxide Synthases; Punctures; Sulfonamides; Survival Analysis

2001
Selected contribution: synergism between TNF-alpha and IL-1 beta in airway smooth muscle cells: implications for beta-adrenergic responsiveness.
    Journal of applied physiology (Bethesda, Md. : 1985), 2001, Volume: 91, Issue:3

    Topics: Adrenergic beta-Agonists; Antineoplastic Agents; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Synergism; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Isoenzymes; Isoproterenol; Magnetics; Membrane Proteins; Mitogen-Activated Protein Kinases; Muscle, Smooth; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Receptors, Adrenergic, beta; Signal Transduction; Sulfonamides; Trachea; Tumor Necrosis Factor-alpha

2001
PGE2 suppresses intestinal T cell function in thermal injury: a cause of enhanced bacterial translocation.
    Shock (Augusta, Ga.), 2001, Volume: 16, Issue:3

    Topics: Animals; Bacterial Translocation; Burns; Cyclooxygenase Inhibitors; Dinoprostone; Indomethacin; Intestines; Lymph Nodes; Male; Nitrobenzenes; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Rats; Rats, Sprague-Dawley; Sulfonamides; T-Lymphocytes

2001
NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis.
    Nature medicine, 2001, Volume: 7, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; cdc42 GTP-Binding Protein; Cell Division; Cell Movement; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Endothelium, Vascular; Fibroblast Growth Factor 2; Humans; Isoenzymes; Membrane Proteins; Mice; Mice, Nude; Neovascularization, Physiologic; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; rac GTP-Binding Proteins; Receptors, Vitronectin; Sulfonamides; Thromboxane A2

2001
CaR-mediated COX-2 expression in primary cultured mTAL cells.
    American journal of physiology. Renal physiology, 2001, Volume: 281, Issue:4

    Topics: Animals; Calcium; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gene Expression; Isoenzymes; Loop of Henle; Male; Nitrobenzenes; Peptides; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, Calcium-Sensing; Receptors, Cell Surface; RNA, Messenger; Sulfonamides

2001
Cyclooxygenase-2 inhibitor ns-398 protects neuronal cultures from lipopolysaccharide-induced neurotoxicity.
    Stroke, 2001, Volume: 32, Issue:10

    Topics: Animals; Animals, Newborn; Antigens, Differentiation; Cell Death; Cells, Cultured; Coculture Techniques; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Immunohistochemistry; Isoenzymes; L-Lactate Dehydrogenase; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Neuroglia; Neurons; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Tumor Necrosis Factor-alpha

2001
Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci.
    Arthritis and rheumatism, 2001, Volume: 44, Issue:9

    Topics: Aged; Amidines; Benzylamines; Cell Survival; Cells, Cultured; Cyclooxygenase Inhibitors; Cytokines; Dinoprostone; Drug Synergism; Enzyme Inhibitors; Humans; Interleukin-1; Interleukin-17; Menisci, Tibial; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Nitrobenzenes; omega-N-Methylarginine; Osteoarthritis, Knee; Sulfonamides; Tumor Necrosis Factor-alpha

2001
Prostanoids in the preoptic hypothalamus mediate systemic lipopolysaccharide-induced hyperalgesia in rats.
    Brain research, 2001, Oct-19, Volume: 916, Issue:1-2

    Topics: Animals; Bacterial Infections; Body Temperature; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Hypothalamus; Isoenzymes; Lipopolysaccharides; Male; Membrane Proteins; Nitrobenzenes; Pain Measurement; Pain Threshold; Preoptic Area; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Reaction Time; Septal Nuclei; Sulfonamides

2001
Sepsis-induced alteration in T-cell Ca(2+) signaling in neonatal rats.
    Biology of the neonate, 2001, Volume: 80, Issue:4

    Topics: Animals; Animals, Newborn; Bacteroides Infections; Calcium; Concanavalin A; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Escherichia coli Infections; Isoenzymes; Lymphocyte Activation; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Resveratrol; Sepsis; Signal Transduction; Spleen; Stilbenes; Sulfonamides; T-Lymphocytes

2001
Synovial cells from a patient with rheumatoid arthritis produce osteoclastogenesis inhibitory factor/osteoprotegerin: reciprocal regulation of the production by inflammatory cytokines and basic fibroblast growth factor.
    Journal of bone and mineral metabolism, 2001, Volume: 19, Issue:6

    Topics: Arthritis, Rheumatoid; Bone Resorption; Cells, Cultured; Culture Media, Conditioned; Dinoprostone; Fibroblast Growth Factor 2; Gene Expression Regulation; Glycoproteins; Humans; Interleukin-1; Nitrobenzenes; Osteoprotegerin; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Sulfonamides; Synovial Membrane

2001
Human airway smooth muscle cells secrete vascular endothelial growth factor: up-regulation by bradykinin via a protein kinase C and prostanoid-dependent mechanism.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:13

    Topics: Adult; Arachidonic Acid; Bradykinin; Bradykinin Receptor Antagonists; Cell Survival; Cells, Cultured; Cyclic AMP; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Growth Factors; Enzyme Inhibitors; Female; Gene Expression; Humans; Indomethacin; Lymphokines; Male; Middle Aged; Muscle, Smooth, Vascular; Naphthalenes; Nitrobenzenes; Prostaglandins; Protein Isoforms; Protein Kinase C; Receptor, Bradykinin B2; Receptors, Bradykinin; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sulfonamides; Time Factors; Trachea; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2001
Host response to infection: the role of CpG DNA in induction of cyclooxygenase 2 and nitric oxide synthase 2 in murine macrophages.
    Infection and immunity, 2001, Volume: 69, Issue:12

    Topics: Adjuvants, Immunologic; Animals; CpG Islands; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Induction; Interleukin-12; Interleukin-6; Isoenzymes; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrobenzenes; omega-N-Methylarginine; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Tumor Necrosis Factor-alpha

2001
Non-steroidal anti-inflammatory drugs inhibit matrix metalloproteinase-2 expression via repression of transcription in lung cancer cells.
    FEBS letters, 2001, Nov-23, Volume: 508, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Culture Media, Conditioned; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Humans; Lung Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Nitrobenzenes; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Transcription, Genetic; Transfection; Tumor Cells, Cultured

2001
Constitutive expression of the cyclooxygenase-2 gene in T-cell lines infected with human T cell leukemia virus type I.
    International journal of cancer, 2001, Dec-15, Volume: 94, Issue:6

    Topics: Apoptosis; bcl-X Protein; Blotting, Northern; Cell Division; Cell Line; Cyclooxygenase 2; Dinoprostone; Gene Products, tax; Genes, bcl-2; Human T-lymphotropic virus 1; Humans; Isoenzymes; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; T-Lymphocytes

2001
Cyclooxygenase-2-mediated regulation of Kupffer cell interleukin-6 production following trauma-hemorrhage and subsequent sepsis.
    Shock (Augusta, Ga.), 2001, Volume: 16, Issue:6

    Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; In Vitro Techniques; Inflammation Mediators; Interleukin-6; Isoenzymes; Kupffer Cells; Male; Mice; Mice, Inbred C3H; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sepsis; Shock, Hemorrhagic; Sulfonamides; Tumor Necrosis Factor-alpha; Wounds and Injuries

2001
Regulation of prostaglandin endoperoxide synthase-2 and IL-6 expression in mouse bone marrow-derived mast cells by exogenous but not endogenous prostanoids.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Feb-01, Volume: 168, Issue:3

    Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Cells; Cells, Cultured; Cyclooxygenase 2; Cytokines; Dinoprostone; Interleukin-6; Isoenzymes; Male; Mast Cells; Mice; Mice, Inbred BALB C; Nitrobenzenes; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfonamides

2002
Cyclooxygenase-2 is induced in monocytes by peroxisome proliferator activated receptor gamma and oxidized alkyl phospholipids from oxidized low density lipoprotein.
    The Journal of biological chemistry, 2002, Apr-12, Volume: 277, Issue:15

    Topics: Base Sequence; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; DNA Primers; Enzyme Induction; Humans; Immunohistochemistry; Isoenzymes; Lipoproteins, LDL; Membrane Proteins; Monocytes; Nitrobenzenes; Oxidation-Reduction; Phospholipids; Prostaglandin-Endoperoxide Synthases; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Sulfonamides; Thiazoles; Thiazolidinediones; Transcription Factors

2002
The cyclooxygenase system participates in functional mdr1b overexpression in primary rat hepatocyte cultures.
    Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Epidermal Growth Factor; Gene Expression Regulation; Hepatocytes; Indomethacin; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; RNA, Messenger; Sulfonamides; Transcriptional Activation

2002
Enteroinvasive bacteria alter barrier and transport properties of human intestinal epithelium: role of iNOS and COX-2.
    Gastroenterology, 2002, Volume: 122, Issue:4

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Biological Transport; Caco-2 Cells; Chlorides; Cyclic AMP; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cystic Fibrosis Transmembrane Conductance Regulator; Diarrhea; Dinoprostone; Electric Impedance; Enzyme Inhibitors; Epithelial Cells; Escherichia coli Infections; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; HT29 Cells; Humans; Intestinal Mucosa; Isoenzymes; Membrane Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrobenzenes; Peroxynitrous Acid; Prostaglandin-Endoperoxide Synthases; Salmonella Infections; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Sulfonamides; Up-Regulation; Water-Electrolyte Balance

2002
[Effects of cyclooxygenase-2 on formation and healing of acetic acid-induced gastric ulcer in rats].
    Zhonghua yi xue za zhi, 2001, Nov-25, Volume: 81, Issue:22

    Topics: Acetic Acid; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Gastric Mucosa; Isoenzymes; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stomach Ulcer; Sulfonamides; Wound Healing

2001
[The effects of butyrates and non-steroidal anti-inflammatory agents on HT-29 colonic carcinoma cells].
    Zhonghua nei ke za zhi, 2002, Volume: 41, Issue:3

    Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Butyrates; Colonic Neoplasms; Dinoprostone; Flow Cytometry; HT29 Cells; Humans; Microscopy, Electron, Scanning; Nitrobenzenes; Sulfonamides

2002
Prostaglandin E2 down-regulates viable Bacille Calmette-Guérin-induced macrophage cytotoxicity against murine bladder cancer cell MBT-2 in vitro.
    Clinical and experimental immunology, 2002, Volume: 128, Issue:1

    Topics: Animals; Antibodies; BCG Vaccine; Cells, Cultured; Cyclooxygenase Inhibitors; Cytokines; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic; Dinoprostone; Down-Regulation; Female; Indomethacin; Interferon-gamma; Macrophages; Macrophages, Peritoneal; Mice; Mice, Inbred C3H; Nitrobenzenes; Sulfonamides; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Urinary Bladder Neoplasms

2002
Effects of Ginkgetin from Ginkgo biloba Leaves on cyclooxygenases and in vivo skin inflammation.
    Planta medica, 2002, Volume: 68, Issue:4

    Topics: Animals; Biflavonoids; Blotting, Western; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Flavonoids; Ginkgo biloba; Indomethacin; Inflammation; Isoenzymes; Macrophages; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Monocytes; Nitrobenzenes; Phospholipases; Plant Extracts; Plant Leaves; Prostaglandin-Endoperoxide Synthases; Skin; Sulfonamides

2002
Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity.
    Journal of neurophysiology, 2002, Volume: 87, Issue:6

    Topics: Action Potentials; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dendrites; Dentate Gyrus; Dinoprostone; Excitatory Postsynaptic Potentials; Isoenzymes; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Nitrobenzenes; Organ Culture Techniques; Perforant Pathway; Presynaptic Terminals; Prostaglandin-Endoperoxide Synthases; Signal Transduction; Sulfonamides; Synapses

2002
The COX-2 inhibitor NS-398 causes T-cell developmental disruptions independent of COX-2 enzyme inhibition.
    Cellular immunology, 2001, Dec-15, Volume: 214, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Immunologic Deficiency Syndromes; Indomethacin; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Nitrobenzenes; Organ Culture Techniques; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Sulfonamides; T-Lymphocytes; Thiophenes; Thymus Gland

2001
Dopamine D(2) receptor-induced COX-2-mediated production of prostaglandin E(2) in D(2)-transfected Chinese hamster ovary cells without simultaneous administration of a Ca(2+)-mobilizing agent.
    Biochemical pharmacology, 2002, Jun-15, Volume: 63, Issue:12

    Topics: Animals; Arachidonic Acids; Calcium; Calcium Channel Blockers; CHO Cells; Cricetinae; Cyclooxygenase 2; Dinoprostone; Dopamine; Dopamine Antagonists; Drug Interactions; Enzyme Inhibitors; Gallic Acid; Indomethacin; Isoenzymes; Naphthalenes; Nitrobenzenes; Phosphatidylcholines; Prostaglandin-Endoperoxide Synthases; Pyrones; Quinacrine; Receptors, Dopamine D2; Salicylamides; Salicylates; Sulfonamides; Tetradecanoylphorbol Acetate; Transfection

2002
Effects of TNFalpha and prostaglandin E2 on the expression of MMPs in human periodontal ligament fibroblasts.
    Journal of periodontal research, 2002, Volume: 37, Issue:3

    Topics: Analysis of Variance; Blotting, Western; Bucladesine; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Gene Expression; Humans; Immunoenzyme Techniques; Isoenzymes; Matrix Metalloproteinases; Membrane Proteins; Nitrobenzenes; Periodontal Ligament; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Tumor Necrosis Factor-alpha

2002
NS-398, a selective cyclooxygenase 2 inhibitor, inhibited cell growth and induced cell cycle arrest in human hepatocellular carcinoma cell lines.
    International journal of cancer, 2002, Jun-10, Volume: 99, Issue:5

    Topics: 6-Ketoprostaglandin F1 alpha; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; G1 Phase; Humans; Isoenzymes; Liver Neoplasms; Membrane Proteins; Nitrobenzenes; Proliferating Cell Nuclear Antigen; Prostaglandin-Endoperoxide Synthases; Resting Phase, Cell Cycle; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S Phase; Sulfonamides; Tumor Cells, Cultured

2002
Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition.
    Arthritis and rheumatism, 2002, Volume: 46, Issue:7

    Topics: Acetates; Alkaline Phosphatase; Blotting, Western; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Nitrobenzenes; Osteoarthritis; Osteoblasts; Osteocalcin; Pyrroles; Quinolines; Sulfonamides

2002
Involvement of 85-kd cytosolic phospholipase A(2) and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells.
    Hepatology (Baltimore, Md.), 2002, Volume: 36, Issue:2

    Topics: Arachidonic Acids; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Division; Cholangiocarcinoma; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Dinoprost; Dinoprostone; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Imidazoles; Interleukin-6; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinases; Nitrobenzenes; Organophosphonates; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Sulfonamides; Tumor Cells, Cultured

2002
Bradykinin increases IL-8 generation in airway epithelial cells via COX-2-derived prostanoids.
    American journal of physiology. Lung cellular and molecular physiology, 2002, Volume: 283, Issue:3

    Topics: Arachidonic Acid; Bradykinin; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cystic Fibrosis; Dinoprostone; Epithelial Cells; Humans; Indomethacin; Interleukin-8; Isoenzymes; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfonamides; Trachea

2002
Cyclooxygenase cloning in dogfish shark, Squalus acanthias, and its role in rectal gland Cl secretion.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 283, Issue:3

    Topics: Amino Acid Sequence; Anal Canal; Animals; Base Sequence; Chlorides; Cloning, Molecular; Cyclooxygenase Inhibitors; Dinoprostone; DNA, Complementary; Dogfish; Male; Molecular Sequence Data; Natriuretic Peptide, C-Type; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rectum; RNA, Messenger; Sulfonamides; Vasoactive Intestinal Peptide

2002
COX-2 selective inhibition reverses the trophic properties of gastrin in colorectal cancer.
    British journal of cancer, 2002, Aug-27, Volume: 87, Issue:5

    Topics: Adenocarcinoma; Animals; Cell Division; Colonic Neoplasms; Cyclin D1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; DNA Replication; Dose-Response Relationship, Drug; Gastrins; Gene Expression Regulation, Neoplastic; Genes, Reporter; Isoenzymes; Male; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Neoplasm Transplantation; Nitrobenzenes; Proliferating Cell Nuclear Antigen; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Receptors, Cholecystokinin; Substrate Specificity; Sulfonamides; Transfection; Tumor Cells, Cultured

2002
The skin fungus-induced Th1- and Th2-related cytokine, chemokine and prostaglandin E2 production in peripheral blood mononuclear cells from patients with atopic dermatitis and psoriasis vulgaris.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2002, Volume: 32, Issue:8

    Topics: Adult; Antigens, Fungal; Candida albicans; Case-Control Studies; Chemokine CCL22; Chemokine CXCL10; Chemokines, CC; Chemokines, CXC; Cyclooxygenase Inhibitors; Dermatitis, Atopic; Dermatomycoses; Dinoprostone; Female; Humans; Indomethacin; Interferon-gamma; Interleukin-4; Leukocytes, Mononuclear; Malassezia; Male; Nitrobenzenes; Psoriasis; Pyrazoles; Sulfonamides; Th1 Cells; Th2 Cells; Trichophyton

2002
Human fallopian tubes express prostacyclin (PGI) synthase and cyclooxygenases and synthesize abundant PGI.
    The Journal of clinical endocrinology and metabolism, 2002, Volume: 87, Issue:9

    Topics: Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Dinoprostone; Epithelial Cells; Epoprostenol; Fallopian Tubes; Female; Humans; Immunohistochemistry; Intramolecular Oxidoreductases; Isoenzymes; Membrane Proteins; Microsomes; Muscle Contraction; Muscle, Smooth; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides

2002
Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury.
    Brain research. Molecular brain research, 2002, Aug-15, Volume: 104, Issue:2

    Topics: Animals; Animals, Newborn; Astrocytes; Brain; Cell Culture Techniques; Chemokine CCL2; Chemokine CXCL2; Chemokines; Cyclooxygenase 2; Cytokines; Dinoprostone; Encephalitis; Gene Expression Regulation, Enzymologic; Intercellular Adhesion Molecule-1; Isoenzymes; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C3H; Microglia; Nitric Oxide Synthase; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides

2002
A role for cyclooxygenase-2 in lipopolysaccharide-induced anorexia in rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 283, Issue:4

    Topics: Analgesics, Non-Narcotic; Animals; Anorexia; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Eating; Isoenzymes; Lipopolysaccharides; Male; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Sulfonamides

2002
Inhibition of the expression of alpha-smooth muscle actin in human hepatic stellate cell line, LI90, by a selective cyclooxygenase 2 inhibitor, NS-398.
    Biochemical and biophysical research communications, 2002, Oct-11, Volume: 297, Issue:5

    Topics: Actins; Blotting, Western; Cell Line; Collagen Type IV; Culture Media; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Matrix; Humans; Hyaluronic Acid; Interleukin-6; Interleukin-8; Isoenzymes; Liver; Membrane Proteins; Muscle, Smooth; Nitrobenzenes; Proliferating Cell Nuclear Antigen; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Time Factors

2002
Delta-opioid receptor-induced late preconditioning is mediated by cyclooxygenase-2 in conscious rabbits.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:5

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzamides; Benzylidene Compounds; Celecoxib; Consciousness; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Heart Rate; Ischemic Preconditioning, Myocardial; Isoenzymes; Male; Myocardial Infarction; Myocardial Stunning; Myocardium; Naltrexone; Narcotic Antagonists; Nitrobenzenes; Piperazines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rabbits; Receptors, Opioid, delta; Sulfonamides

2002
Gastrin enhances gastric mucosal integrity through cyclooxygenase-2 upregulation in rats.
    American journal of physiology. Gastrointestinal and liver physiology, 2002, Volume: 283, Issue:6

    Topics: Animals; Antibodies; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Epidermal Growth Factor; Ethanol; Gastric Mucosa; Gastrins; Heparin-binding EGF-like Growth Factor; Hepatocyte Growth Factor; Hydrogen-Ion Concentration; Immunoenzyme Techniques; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Sulfonamides

2002
NS-398: cyclooxygenase-2 independent inhibition of leukocyte priming for lipid body formation and enhanced leukotriene generation.
    Prostaglandins, leukotrienes, and essential fatty acids, 2002, Volume: 67, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Isoenzymes; Leukocytes; Leukotriene B4; Leukotrienes; Lipid Metabolism; Mice; Mice, Knockout; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides

2002
Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line.
    The Journal of biological chemistry, 2002, Dec-20, Volume: 277, Issue:51

    Topics: Active Transport, Cell Nucleus; Arachidonic Acid; Catalysis; Cell Nucleus; Culture Media, Serum-Free; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Dinoprostone; Endothelial Growth Factors; Enzyme Inhibitors; Flavonoids; Green Fluorescent Proteins; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Intercellular Signaling Peptides and Proteins; Isoenzymes; Luminescent Proteins; Lymphokines; Male; MAP Kinase Signaling System; Meloxicam; Membrane Proteins; Nitrobenzenes; Phosphatidylinositol 3-Kinases; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Thiazines; Thiazoles; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2002
Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells.
    Cancer research, 2002, Nov-01, Volume: 62, Issue:21

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase Inhibitors; Caspases; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytochrome c Group; Dinoprostone; Enzyme Activation; Fluorouracil; Humans; Isoenzymes; Membrane Proteins; Mitochondria; Nitrobenzenes; Nucleic Acid Synthesis Inhibitors; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Sulfonamides; Transfection; Tumor Cells, Cultured

2002
Pro-inflammatory effect of freshly solubilized beta-amyloid peptides in the brain.
    Prostaglandins & other lipid mediators, 2002, Volume: 70, Issue:1-2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cattle; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Humans; In Vitro Techniques; Inflammation; Inflammation Mediators; Isoenzymes; Male; Membrane Proteins; Mitogen-Activated Protein Kinases; Myocytes, Smooth Muscle; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Rats; Solubility; Sulfonamides

2002
Wound healing involves induction of cyclooxygenase-2 expression in rat skin.
    Laboratory investigation; a journal of technical methods and pathology, 2002, Volume: 82, Issue:11

    Topics: Animals; Blotting, Western; Capillaries; Cyclooxygenase 2; Dinoprostone; Endothelial Growth Factors; Enzyme Induction; Fibroblast Growth Factor 2; Immunohistochemistry; In Situ Hybridization; Indomethacin; Intercellular Signaling Peptides and Proteins; Isoenzymes; Lymphokines; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Skin; Sulfonamides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wound Healing

2002
Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.
    Journal of natural products, 2002, Volume: 65, Issue:11

    Topics: Acrolein; Alkaloids; Animals; Anthraquinones; Aspirin; Biological Assay; Catalysis; Cinnamomum zeylanicum; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Eugenol; Flavonoids; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Kinetics; Lactones; Models, Molecular; Nitrobenzenes; Oleanolic Acid; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Pyrogallol; Steroids; Sulfonamides; Sulfones; Syzygium; Terpenes; Triterpenes; Ursolic Acid

2002
Cyclooxygenase-2 inhibitor enhances whereas prostaglandin E2 inhibits the production of interferon-induced protein of 10 kDa in epidermoid carcinoma A431.
    The Journal of investigative dermatology, 2002, Volume: 119, Issue:5

    Topics: Carcinoma, Squamous Cell; Chemokine CXCL10; Chemokines, CXC; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gene Expression; Humans; Interferon-Stimulated Gene Factor 3; Isoenzymes; Janus Kinase 1; Janus Kinase 2; Membrane Proteins; Nitrobenzenes; Phosphorylation; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Prostaglandin E; Response Elements; RNA, Messenger; Signal Transduction; Skin Neoplasms; Sulfonamides; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine

2002
Inhibition of cyclooxygenase-2: effects on renin secretion and expression in fetal lambs.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2003, Volume: 284, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Blood Gas Analysis; Cells, Cultured; Colforsin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Female; Gene Expression Regulation, Developmental; Heart Rate; Isoenzymes; Isoproterenol; Kidney Cortex; Nitrobenzenes; Phosphodiesterase Inhibitors; Pregnancy; Prostaglandin-Endoperoxide Synthases; Renin; Renin-Angiotensin System; RNA, Messenger; Sheep, Domestic; Sulfonamides

2003
Requirement of cyclooxygenase-2 expression and prostaglandins for human prostate cancer cell invasion.
    Clinical & experimental metastasis, 2002, Volume: 19, Issue:7

    Topics: 6-Ketoprostaglandin F1 alpha; Adenocarcinoma; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Humans; Indomethacin; Isoenzymes; Male; Membrane Proteins; Neoplasm Invasiveness; Nitrobenzenes; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Prostatic Neoplasms; Sulfonamides; Tumor Cells, Cultured

2002
Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors.
    Journal of immunology (Baltimore, Md. : 1950), 2003, Jan-15, Volume: 170, Issue:2

    Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Cyclooxygenase 2; Dexamethasone; Dinoprostone; Flurbiprofen; Humans; Indomethacin; Isoenzymes; Lung; Membrane Proteins; Muscle, Smooth; NF-kappa B; Nitrobenzenes; Promoter Regions, Genetic; Prostaglandin Antagonists; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Transport; Receptors, Cytoplasmic and Nuclear; Response Elements; Sulfonamides; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation

2003
Interleukin-1beta induces glycosaminoglycan synthesis via the prostaglandin E2 pathway in cultured human cervical fibroblasts.
    Molecular human reproduction, 2003, Volume: 9, Issue:1

    Topics: Base Sequence; Biphenyl Compounds; Cells, Cultured; Cervix Uteri; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; DNA Primers; Female; Fibroblasts; Glycosaminoglycans; Humans; Interleukin-1; Isoenzymes; Kinetics; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Receptors, Prostaglandin E, EP4 Subtype; RNA, Messenger; Sulfonamides; Transcription, Genetic

2003
Potential involvement of the cyclooxygenase-2 pathway in the regulation of tumor-associated angiogenesis and growth in pancreatic cancer.
    Molecular cancer therapeutics, 2003, Volume: 2, Issue:1

    Topics: Capillaries; Cell Division; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Endothelial Growth Factors; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; Homeostasis; Humans; Intercellular Signaling Peptides and Proteins; Isoenzymes; Lymphokines; Membrane Proteins; Neovascularization, Pathologic; Nitrobenzenes; Pancreatic Neoplasms; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2003
Inhibited proliferation of cyclooxygenase-2 expressing human hepatoma cells by NS-398, a selective COX-2 inhibitor.
    International journal of oncology, 2003, Volume: 22, Issue:4

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Bromodeoxyuridine; Carcinoma, Hepatocellular; Cell Cycle; Cell Division; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Immunohistochemistry; Isoenzymes; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Time Factors

2003
Cyclooxygenase (COX) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxygenase independent pathways.
    Lung cancer (Amsterdam, Netherlands), 2003, Volume: 40, Issue:1

    Topics: Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytochrome c Group; Dinoprostone; Flavoproteins; Humans; Immunoenzyme Techniques; Indomethacin; Isoenzymes; Lung Neoplasms; Membrane Proteins; Microscopy, Fluorescence; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Proteins; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sulfonamides; Tumor Cells, Cultured

2003
T-cell proliferative responses following sepsis in neonatal rats.
    Biology of the neonate, 2003, Volume: 83, Issue:3

    Topics: Animals; Animals, Newborn; Bacteroides fragilis; Bacteroides Infections; Blood Glucose; Cell Division; Cyclooxygenase Inhibitors; Dinoprostone; Escherichia coli Infections; Female; Interleukin-2; Lactic Acid; Male; Nitrobenzenes; Rats; Rats, Sprague-Dawley; Spleen; Sulfonamides; T-Lymphocytes

2003
Crystal-induced neutrophil activation: VIII. Immediate production of prostaglandin E2 mediated by constitutive cyclooxygenase 2 in human neutrophils stimulated by urate crystals.
    Arthritis and rheumatism, 2003, Volume: 48, Issue:4

    Topics: Arachidonic Acid; Crystallization; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Humans; Isoenzymes; Leukotriene B4; Membrane Proteins; Neutrophil Activation; Neutrophils; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Stilbenes; Sulfonamides; Uric Acid

2003
Immunomodulatory effects of the tobacco-specific carcinogen, NNK, on alveolar macrophages.
    Clinical and experimental immunology, 2003, Volume: 132, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Carcinogens; Cell Line; Chemokine CCL3; Chemokine CCL4; Cyclooxygenase Inhibitors; Depression, Chemical; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Interleukin-10; Interleukin-12; Lipopolysaccharides; Macrophage Inflammatory Proteins; Macrophages, Alveolar; Nitric Oxide; Nitrobenzenes; Nitrosamines; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Smoking; Sulfonamides; Time Factors; Tumor Necrosis Factor-alpha

2003
Cyclooxygenase-2 inhibitor NS-398 suppresses cell growth and constitutive production of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells.
    Cancer science, 2003, Volume: 94, Issue:2

    Topics: Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Progression; Drug Screening Assays, Antitumor; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; Interleukin-1; Isoenzymes; Lung Neoplasms; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; NF-kappa B; Nitrobenzenes; Proline; Prostaglandin-Endoperoxide Synthases; Pyridines; Recombinant Proteins; Sulfonamides; Thiocarbamates; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2003
The cyclooxygenase 2-selective inhibitor NS398 inhibits proliferation of oral carcinoma cell lines by mechanisms dependent and independent of reduced prostaglandin E2 synthesis.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Volume: 9, Issue:5

    Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Epithelial Cells; Humans; Isoenzymes; Keratinocytes; Membrane Proteins; Mouth Neoplasms; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Transfection; Tumor Cells, Cultured

2003
Cyclooxygenase-2 mediates mucin secretion from epithelial cells of lipopolysaccharide-treated canine gallbladder.
    Digestive diseases and sciences, 2003, Volume: 48, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cells, Cultured; Cholelithiasis; Cyclic AMP; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dogs; Epithelial Cells; Gallbladder; In Vitro Techniques; Indomethacin; Isoenzymes; Lipopolysaccharides; Mucins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides

2003
Mechanotransduction in bone cells proceeds via activation of COX-2, but not COX-1.
    Biochemical and biophysical research communications, 2003, Jun-06, Volume: 305, Issue:3

    Topics: Animals; Bone and Bones; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Activation; Humans; Isoenzymes; Mechanotransduction, Cellular; Membrane Proteins; Mice; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; RNA, Messenger; Stress, Mechanical; Sulfonamides

2003
Enhancement of carcinogen-induced malignant cell transformation by prostaglandin F(2 alpha).
    Toxicology, 2003, Jun-30, Volume: 188, Issue:2-3

    Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Fibroblasts; Methylcholanthrene; Methylnitronitrosoguanidine; Mice; Mice, Inbred C3H; Nitrobenzenes; Polychlorinated Dibenzodioxins; Sulfonamides; Tetradecanoylphorbol Acetate

2003
Cyclooxygenase 2 and intermittent hypoxia-induced spatial deficits in the rat.
    American journal of respiratory and critical care medicine, 2003, Aug-15, Volume: 168, Issue:4

    Topics: Analysis of Variance; Animals; Apoptosis; Cerebral Cortex; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gene Expression Regulation, Enzymologic; Hypoxia; Isoenzymes; Male; Maze Learning; Membrane Proteins; Memory Disorders; Neurons; Nitrobenzenes; Peroxidases; Prostaglandin-Endoperoxide Synthases; Random Allocation; Rats; Rats, Sprague-Dawley; Sleep Apnea Syndromes; Sulfonamides; Time Factors

2003
Induction of cyclooxygenase-2 accounts for restraint stress-induced oxidative status in rat brain.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:9

    Topics: Animals; Antioxidants; Blotting, Western; Brain; Brain Chemistry; Calcium; Cell Nucleus; Cell Size; Corticosterone; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Dinoprostone; Dizocilpine Maleate; Drug Interactions; Electrophoretic Mobility Shift Assay; Glutathione; Immobilization; Immunohistochemistry; Isoenzymes; Male; Malondialdehyde; Neurons; Neuroprotective Agents; NF-kappa B; Nitric Oxide Synthase; Nitrobenzenes; Proline; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stress, Physiological; Sulfonamides; Thiocarbamates; Time Factors

2003
Cyclooxygenase-2 is induced in the endothelial cells throughout the central nervous system during carrageenan-induced hind paw inflammation; its possible role in hyperalgesia.
    Journal of neurochemistry, 2003, Volume: 86, Issue:2

    Topics: Animals; Brain; Carrageenan; Central Nervous System; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Endothelium, Vascular; Enzyme Induction; Hindlimb; Hyperalgesia; Immunohistochemistry; Inflammation; Isoenzymes; Male; Nitrobenzenes; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Spinal Cord; Sulfonamides

2003
The protective effect of rebamipide on paracellular permeability of rat gastric epithelial cells.
    Alimentary pharmacology & therapeutics, 2003, Volume: 18 Suppl 1

    Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inhibitors; Dinoprostone; Epithelial Cells; Gastric Mucosa; Indomethacin; Nitrobenzenes; Permeability; Quinolones; Rats; Sulfonamides

2003
Suppressive effect of selective cyclooxygenase-2 inhibitor on cytokine release in human neutrophils.
    International immunopharmacology, 2003, Volume: 3, Issue:10-11

    Topics: Adult; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytokines; Dinoprostone; Dose-Response Relationship, Drug; Humans; Isoenzymes; Membrane Proteins; Neutrophils; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Superoxides

2003
Cyclooxygenase-2 (COX-2) inhibitors sensitize tumor cells specifically to death receptor-induced apoptosis independently of COX-2 inhibition.
    Oncogene, 2003, Sep-11, Volume: 22, Issue:39

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Caspase 3; Caspases; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; fas Receptor; Female; HeLa Cells; Humans; Isoenzymes; Membrane Glycoproteins; Membrane Proteins; Mitochondria; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Receptors, Tumor Necrosis Factor; Sulfonamides; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2003
Leukotriene D4-induced adhesion of Caco-2 cells is mediated by prostaglandin E2 and upregulation of alpha2beta1-integrin.
    Experimental cell research, 2003, Oct-01, Volume: 289, Issue:2

    Topics: Caco-2 Cells; Carcinoma; Cell Adhesion; Colitis; Collagen Type I; Colonic Neoplasms; Cyclooxygenase 2; Dinoprostone; Extracellular Matrix; Humans; Integrin alpha2beta1; Isoenzymes; Leukotriene D4; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Receptors, Leukotriene; Sulfonamides; Up-Regulation; Xanthenes; Xanthones

2003
Evaluation of the contribution of cyclooxygenase 1 and cyclooxygenase 2 to the production of PGE2 and PGF2 alpha in epithelial cells from bovine endometrium.
    Reproduction (Cambridge, England), 2003, Volume: 126, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Blotting, Western; Cattle; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprost; Dinoprostone; Endometrium; Epithelial Cells; Female; Flurbiprofen; Isoenzymes; Nitrobenzenes; Oxytocin; Prostaglandin-Endoperoxide Synthases; Salicylates; Stimulation, Chemical; Sulfonamides

2003
TNFR1 mediates the radioprotective effects of lipopolysaccharide in the mouse intestine.
    American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 286, Issue:1

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Antigens, CD; Apoptosis; Blotting, Western; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Immunohistochemistry; Intestines; Isoenzymes; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Radiation-Protective Agents; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Stem Cells; Sulfonamides; Tumor Necrosis Factor-alpha; Whole-Body Irradiation

2004
Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells.
    The Journal of biological chemistry, 2003, Dec-26, Volume: 278, Issue:52

    Topics: Anthracenes; Apoptosis; Blotting, Western; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Survival; Cyclooxygenase 2; Dactinomycin; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; HeLa Cells; Humans; Imidazoles; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinases; Mutation; NF-kappa B; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Perylene; Photochemotherapy; Precipitin Tests; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Signal Transduction; Sulfonamides; Time Factors; Transcription, Genetic; Transfection; Up-Regulation

2003
COX-2 induction during murine gammaherpesvirus 68 infection leads to enhancement of viral gene expression.
    Journal of virology, 2003, Volume: 77, Issue:23

    Topics: Animals; Cell Line; Cricetinae; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Gammaherpesvirinae; Gene Expression Regulation, Viral; Genes, Viral; Herpesviridae Infections; Indomethacin; Isoenzymes; Mice; Nitrobenzenes; Oligonucleotide Array Sequence Analysis; Prostaglandin-Endoperoxide Synthases; Sulfonamides

2003
Prostaglandin levels in seminal plasma and sperm extracts of the domestic turkey, and the effects of cyclooxygenase inhibitors on sperm mobility.
    Reproductive biology and endocrinology : RB&E, 2003, Oct-09, Volume: 1

    Topics: Alprostadil; Animals; Aspirin; Cell Membrane; Cryopreservation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Isoenzymes; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Resveratrol; Semen; Semen Preservation; Sperm Motility; Spermatozoa; Stilbenes; Sulfonamides; Tolmetin; Turkeys

2003
Increased TNFalpha production and Cox-2 activity in organotypic brain slice cultures from APPsw transgenic mice.
    Neuroscience letters, 2003, Dec-15, Volume: 353, Issue:1

    Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Brain; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Drug Interactions; Isoenzymes; Mice; Mice, Transgenic; Nitrobenzenes; Organ Culture Techniques; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Tumor Necrosis Factor-alpha

2003
Induction of G0/G1 cell cycle arrest in ovarian carcinoma cells by the anti-inflammatory drug NS-398, but not by COX-2-specific RNA interference.
    Oncogene, 2003, Nov-27, Volume: 22, Issue:54

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Cell Line, Tumor; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Female; G1 Phase; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Membrane Proteins; Nitrobenzenes; Ovarian Neoplasms; Prostaglandin-Endoperoxide Synthases; Resting Phase, Cell Cycle; RNA Interference; Sulfonamides

2003
Inhibition of cyclooxygenase-2 improves cardiac function after myocardial infarction in the mouse.
    American journal of physiology. Heart and circulatory physiology, 2004, Volume: 286, Issue:4

    Topics: Animals; Cardiomegaly; Collagen; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Echocardiography; Fibrosis; Heart; Immunohistochemistry; Isoenzymes; Lactones; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; Natriuretic Peptide, Brain; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Sulfones; Transforming Growth Factor beta

2004
Interleukin-1beta, transforming growth factor-beta1, and bradykinin attenuate cyclic AMP production by human pulmonary artery smooth muscle cells in response to prostacyclin analogues and prostaglandin E2 by cyclooxygenase-2 induction and downregulation o
    Circulation research, 2004, Feb-20, Volume: 94, Issue:3

    Topics: Adenylyl Cyclases; Adult; Arachidonic Acid; Bradykinin; Cells, Cultured; Colforsin; Cyclic AMP; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Induction; Epoprostenol; Gene Expression Regulation, Enzymologic; Growth Substances; Humans; Interleukin-1; Isoenzymes; Isoproterenol; Membrane Proteins; Muscle, Smooth, Vascular; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pulmonary Artery; RNA, Messenger; Sulfonamides; Transforming Growth Factor beta; Transforming Growth Factor beta1

2004
Protease-activated receptor-2-mediated contraction of urinary bladder is enhanced in cyclophosphamide-treated rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 2004, Volume: 369, Issue:2

    Topics: Animals; Cyclooxygenase 2; Cyclophosphamide; Cystitis; Dinoprostone; In Vitro Techniques; Indomethacin; Isoenzymes; Male; Mucous Membrane; Muscle Contraction; Muscle, Smooth; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Receptor, PAR-2; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Trypsin; Urinary Bladder

2004
Novel combination of cyclooxygenase-2 and MEK inhibitors in human hepatocellular carcinoma provides a synergistic increase in apoptosis.
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2003, Volume: 7, Issue:8

    Topics: Adenocarcinoma; Apoptosis; Butadienes; Carcinoma, Hepatocellular; Cell Cycle; Cell Division; Cell Line, Tumor; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Drug Synergism; Enzyme Inhibitors; Humans; Isoenzymes; Liver Neoplasms; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Nitrobenzenes; Pancreatic Neoplasms; Prostaglandin-Endoperoxide Synthases; Signal Transduction; Sulfonamides

2003
COX-2 is essential for EGF induction of cell proliferation in gastric RGM1 cells.
    Digestive diseases and sciences, 2003, Volume: 48, Issue:12

    Topics: Animals; Blotting, Western; Cell Division; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Epidermal Growth Factor; Flavonoids; Gastric Mucosa; Isoenzymes; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Signal Transduction; Stomach; Sulfonamides

2003
Novel regulatory mechanisms of CD40-induced prostanoid synthesis by IL-4 and IL-10 in human monocytes.
    Journal of immunology (Baltimore, Md. : 1950), 2004, Feb-15, Volume: 172, Issue:4

    Topics: Antibodies, Monoclonal; Carrier Proteins; CD40 Antigens; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Flavonoids; Humans; Imidazoles; Interleukin-10; Interleukin-4; Isoenzymes; Ligands; MAP Kinase Signaling System; Membrane Proteins; Monocytes; NF-kappa B; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein Transport; Pyridines; Recombinant Proteins; Repressor Proteins; Sulfonamides

2004
Effect of bismuth subgallate on nitric oxide and prostaglandin E2 production by macrophages.
    Biochemical and biophysical research communications, 2004, Mar-19, Volume: 315, Issue:4

    Topics: Animals; Blotting, Northern; Blotting, Western; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Escherichia coli; Gallic Acid; Interferon-gamma; Isoenzymes; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrobenzenes; Nitroprusside; Organometallic Compounds; Prostaglandin-Endoperoxide Synthases; Recombinant Proteins; RNA, Messenger; Sulfonamides; Transforming Growth Factor beta

2004
Inhibition of human glioma cell growth by a PHS-2 inhibitor, NS398, and a prostaglandin E receptor subtype EP1-selective antagonist, SC51089.
    Journal of neuro-oncology, 2004, Volume: 66, Issue:3

    Topics: Animals; Brain Neoplasms; Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Female; Glioma; Humans; Hydrazines; Isoenzymes; Membrane Proteins; Mice; Mice, SCID; Nitrobenzenes; Oxazepines; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Sulfonamides; Transplantation, Heterologous; Tumor Cells, Cultured; Xanthones

2004
A new pyrazolo pyrimidine derivative inhibitor of cyclooxygenase-2 with anti-angiogenic activity.
    European journal of pharmacology, 2004, Mar-19, Volume: 488, Issue:1-3

    Topics: Angiogenesis Inhibitors; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Edema; Female; Granuloma; Interleukin-1; Isoenzymes; Mice; Neovascularization, Pathologic; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyrimidines; Rats; Rats, Wistar; Sulfonamides; Tumor Necrosis Factor-alpha; Zymosan

2004
Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells.
    International journal of oncology, 2004, Volume: 24, Issue:5

    Topics: Apoptosis; Blotting, Western; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Endometrial Neoplasms; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, Dominant; Humans; Isoenzymes; Membrane Proteins; Mutation; Nitrobenzenes; Phosphatidylinositol 3-Kinases; Phosphoric Monoester Hydrolases; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Tumor Cells, Cultured; Tumor Suppressor Proteins

2004
Selective COX-2 inhibitor, NS-398, inhibits the replicative senescence of cultured dermal fibroblasts.
    Mechanisms of ageing and development, 2004, Volume: 125, Issue:5

    Topics: Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Cellular Senescence; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Fibroblasts; Humans; Isoenzymes; Male; Matrix Metalloproteinase 1; Membrane Proteins; Neoplasms; Nitrobenzenes; Proliferating Cell Nuclear Antigen; Prostaglandin-Endoperoxide Synthases; Skin; Sulfonamides; Tumor Suppressor Protein p53

2004
Inhibition of cyclooxygenase-2 by NS-398 following hemorrhage and subsequent sepsis: no beneficial effects in either gender.
    Surgical infections, 2004,Spring, Volume: 5, Issue:1

    Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytokines; Dinoprostone; Disease Models, Animal; Female; Injections, Intraperitoneal; Isoenzymes; Male; Mice; Mice, Inbred CBA; Nitrobenzenes; Probability; Prostaglandin-Endoperoxide Synthases; Reference Values; Sensitivity and Specificity; Sepsis; Sex Factors; Shock, Hemorrhagic; Sulfonamides; Survival Analysis

2004
Induction of cyclooxygenase-1 in cultured synovial cells isolated from rheumatoid arthritis patients.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2004, Volume: 53, Issue:6

    Topics: Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Culture Media, Conditioned; Cyclooxygenase 1; Dexamethasone; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Humans; Immunohistochemistry; Interleukin-1; Isoenzymes; Isoxazoles; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Synovial Membrane; Time Factors

2004
Oncostatin M stimulates the detachment of a reservoir of invasive mammary carcinoma cells: role of cyclooxygenase-2.
    Clinical & experimental metastasis, 2004, Volume: 21, Issue:2

    Topics: Adenocarcinoma; Animals; Cell Adhesion; Cell Line, Tumor; Collagen; Contraindications; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Drug Combinations; Female; Isoenzymes; Laminin; Mammary Neoplasms, Experimental; Mice; Neoplasm Invasiveness; Neoplasm Proteins; Nitrobenzenes; Oncostatin M; Peptides; Prostaglandin-Endoperoxide Synthases; Proteoglycans; Receptors, Cytokine; Receptors, Oncostatin M; RNA, Messenger; Sulfonamides

2004
Inhibition of intrafollicular PGE2 synthesis and ovulation following ultrasound-mediated intrafollicular injection of the selective cyclooxygenase-2 inhibitor NS-398 in cattle.
    Journal of animal science, 2004, Volume: 82, Issue:6

    Topics: Animals; Cattle; Cyclooxygenase Inhibitors; Dinoprostone; Estrus Synchronization; Female; Follicular Fluid; Gonadotropin-Releasing Hormone; Injections; Nitrobenzenes; Ovarian Follicle; Ovulation; Progesterone; Sulfonamides; Ultrasonography

2004
Inhibition of IL-6, TNF-alpha, and cyclooxygenase-2 protein expression by prostaglandin E2-induced IL-10 in bone marrow-derived dendritic cells.
    Cellular immunology, 2004, Volume: 228, Issue:2

    Topics: Animals; Blotting, Western; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dendritic Cells; Dinoprostone; Female; Flow Cytometry; Interleukin-10; Interleukin-6; Isoenzymes; Leukotriene B4; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thromboxane B2; Tumor Necrosis Factor-alpha

2004
Regulation of bone morphogenetic protein-2 expression by endogenous prostaglandin E2 in human mesenchymal stem cells.
    Journal of cellular physiology, 2004, Volume: 200, Issue:3

    Topics: Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Differentiation; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gene Expression Regulation, Developmental; Humans; Isoenzymes; Membrane Proteins; Mesenchymal Stem Cells; Mesoderm; Nitrobenzenes; Osteoblasts; Osteogenesis; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Sulfonamides; Transforming Growth Factor beta

2004
Inhibition of cyclooxygenase-1 and -2 expression by targeting the endothelin a receptor in human ovarian carcinoma cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Jul-15, Volume: 10, Issue:14

    Topics: Animals; Atrasentan; Blotting, Northern; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Endothelin A Receptor Antagonists; Endothelin-1; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Isoenzymes; Luciferases; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Nude; Nitrobenzenes; Ovarian Neoplasms; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyrrolidines; Receptor, Endothelin A; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Transfection; Up-Regulation; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2004
Chlamydia pneumoniae decreases smooth muscle cell proliferation through induction of prostaglandin E2 synthesis.
    Infection and immunity, 2004, Volume: 72, Issue:8

    Topics: Cell Division; Cells, Cultured; Chlamydophila pneumoniae; Culture Media, Conditioned; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Myocytes, Smooth Muscle; Nitrobenzenes; Sulfonamides; Up-Regulation

2004
Interleukin-1beta stimulates matrix metalloproteinase-2 expression via a prostaglandin E2-dependent mechanism in human chondrocytes.
    Experimental & molecular medicine, 2004, Jun-30, Volume: 36, Issue:3

    Topics: Chondrocytes; Cyclooxygenase 2; Dinoprostone; Humans; Indoles; Interleukin-1; Isoenzymes; Matrix Metalloproteinase 2; Membrane Proteins; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Sulfonamides; Up-Regulation

2004
Acute effects of cyclooxygenase-2 inhibition on renal function in heterozygous ren-2-transgenic rats on normal or low sodium intake.
    Kidney & blood pressure research, 2004, Volume: 27, Issue:4

    Topics: Animals; Animals, Genetically Modified; Blood Pressure; Cyclooxygenase Inhibitors; Diet, Sodium-Restricted; Dinoprostone; Glomerular Filtration Rate; Kidney Cortex; Male; Nitrobenzenes; Rats; Renal Circulation; Renin; Renin-Angiotensin System; Sodium, Dietary; Sulfonamides; Thiophenes

2004
Prostaglandin E2 inhibits transforming growth factor beta 1-mediated induction of collagen alpha 1(I) in hepatic stellate cells.
    Journal of hepatology, 2004, Volume: 41, Issue:2

    Topics: Animals; Cell Line, Transformed; Collagen Type I; Collagen Type I, alpha 1 Chain; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; DNA-Binding Proteins; Heat-Shock Proteins; Humans; Isoenzymes; Liver; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; RNA, Messenger; Serpins; Smad Proteins; Sulfonamides; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1

2004
Targeting cyclooxygenase-2 with sodium butyrate and NSAIDs on colorectal adenoma/carcinoma cells.
    World journal of gastroenterology, 2004, Oct-15, Volume: 10, Issue:20

    Topics: Adenoma; Apoptosis; Butyrates; Cell Proliferation; Colorectal Neoplasms; Cyclooxygenase Inhibitors; Dinoprostone; HT29 Cells; Humans; Microscopy, Electron; Nitrobenzenes; Sulfonamides; Tumor Cells, Cultured

2004
Induced microsomal PGE synthase-1 is involved in cyclooxygenase-2-dependent PGE2 production in gastric fibroblasts.
    American journal of physiology. Gastrointestinal and liver physiology, 2005, Volume: 288, Issue:2

    Topics: Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Dinoprostone; Fibroblasts; Gene Expression; Humans; Indoles; Interleukin-1; Membrane Proteins; Microsomes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Stomach; Sulfonamides; Vascular Endothelial Growth Factor A

2005
Endothelial cell confluence regulates cyclooxygenase-2 and prostaglandin E2 production that modulate motility.
    The Journal of biological chemistry, 2004, Dec-31, Volume: 279, Issue:53

    Topics: Blotting, Western; Cell Communication; Cell Movement; Cell Proliferation; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytokines; Dinoprostone; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Humans; Immunoblotting; Membrane Proteins; Microscopy, Fluorescence; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Signal Transduction; Sulfonamides; Umbilical Veins; Wound Healing

2004
Implication of prostaglandin E(2) in TNF-alpha-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs.
    Osteoarthritis and cartilage, 2004, Volume: 12, Issue:11

    Topics: Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Calpain; Cell Line, Tumor; Chondrocytes; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Diclofenac; Dinoprostone; Humans; Nitrobenzenes; Phenylpropionates; Prostaglandin Antagonists; Sulfonamides; Tumor Necrosis Factor-alpha; Up-Regulation; Xanthones

2004
Effect of low- and high-intensity pulsed ultrasound on collagen post-translational modifications in MC3T3-E1 osteoblasts.
    Calcified tissue international, 2004, Volume: 75, Issue:5

    Topics: 3T3 Cells; Animals; Collagen; Cross-Linking Reagents; Culture Media; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Membrane Proteins; Mice; Nitrobenzenes; Osteoblasts; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase; Prostaglandin-Endoperoxide Synthases; Protein Processing, Post-Translational; Protein-Lysine 6-Oxidase; RNA, Messenger; Sulfonamides; Time Factors; Ultrasonics; Ultrasonography, Doppler, Pulsed; Up-Regulation

2004
Down-regulation of interleukin-1alpha-induced matrix metalloproteinase-13 expression via EP1 receptors by prostaglandin E2 in human periodontal ligament cells.
    Oral microbiology and immunology, 2005, Volume: 20, Issue:1

    Topics: Collagenases; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Humans; Indomethacin; Interleukin-1; Matrix Metalloproteinase 13; Nitrobenzenes; Periodontal Ligament; Receptors, Prostaglandin E; Sulfonamides

2005
Acetaminophen-sensitive prostaglandin production in rat cerebral endothelial cells.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2005, Volume: 288, Issue:4

    Topics: 6-Ketoprostaglandin F1 alpha; Acetaminophen; Analgesics, Non-Narcotic; Animals; Blotting, Western; Capillaries; Cells, Cultured; Cerebrovascular Circulation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Cells; Lipopolysaccharides; Male; Membrane Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides

2005
Celecoxib inhibits ureteral contractility and prostanoid release.
    Urology, 2005, Volume: 65, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Celecoxib; Cyclooxygenase Inhibitors; Depression, Chemical; Dimethyl Sulfoxide; Dinoprost; Dinoprostone; Gas Chromatography-Mass Spectrometry; Humans; Indomethacin; Muscle Contraction; Nitrobenzenes; Prostaglandin Antagonists; Prostaglandin D2; Prostaglandins; Pyrazoles; Secretory Rate; Sulfonamides; Sus scrofa; Thromboxane A2; Tumor Necrosis Factor-alpha; Ureter; Ureteral Obstruction

2005
The role of selective nitric oxide synthase inhibitor on nitric oxide and PGE2 levels in refractory hemorrhagic-shocked rats.
    The Journal of surgical research, 2005, Volume: 123, Issue:2

    Topics: Animals; Aspartate Aminotransferases; Blood Pressure; Brain; Creatinine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Guanidines; Immunoblotting; Kidney; Liver; Lung; Male; Nissl Bodies; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Sulfonamides; Survival Rate

2005
Er:YAG laser irradiation increases prostaglandin E production via the induction of cyclooxygenase-2 mRNA in human gingival fibroblasts.
    Journal of periodontal research, 2005, Volume: 40, Issue:2

    Topics: Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Induction; Fibroblasts; Gingiva; Humans; Indomethacin; Laser Therapy; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Wound Healing

2005
Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK.
    The Journal of biological chemistry, 2005, Jun-03, Volume: 280, Issue:22

    Topics: Animals; Bacterial Toxins; Cell Line; Colon; Cyclic AMP; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enterotoxins; Enzyme Activation; Enzyme Inhibitors; Humans; Ileum; Imidazoles; Immunohistochemistry; Inflammation; Intramolecular Oxidoreductases; Luciferases; Membrane Proteins; Mice; Mice, SCID; Models, Biological; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin-E Synthases; Prostaglandin-Endoperoxide Synthases; Protein Binding; Pyridines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Signal Transduction; Sulfonamides; Time Factors; Tissue Transplantation; Transfection

2005
Role of omega-3 polyunsaturated fatty acids on cyclooxygenase-2 metabolism in brain-metastatic melanoma.
    Journal of lipid research, 2005, Volume: 46, Issue:6

    Topics: Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Collagen; Cyclooxygenase 2; Dinoprostone; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Down-Regulation; Drug Combinations; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Gene Expression Regulation, Neoplastic; Humans; Immunoenzyme Techniques; Laminin; Melanoma; Membrane Proteins; Mice; Mice, Nude; Neoplasm Transplantation; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Proteoglycans; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Tumor Necrosis Factor-alpha; Up-Regulation

2005
Hypoxia upregulates cyclooxygenase-2 and prostaglandin E(2) levels in human peritoneal fibroblasts.
    Fertility and sterility, 2005, Volume: 83 Suppl 1

    Topics: Cell Survival; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Fibroblasts; Humans; Hypoxia; Membrane Proteins; Nitrobenzenes; Peritoneum; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Tissue Adhesions

2005
Cytokines upregulate vascular endothelial growth factor secretion by human airway smooth muscle cells: Role of endogenous prostanoids.
    FEBS letters, 2005, May-09, Volume: 579, Issue:12

    Topics: Blotting, Western; Cell Survival; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytokines; Dactinomycin; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Humans; Indomethacin; Interleukin-1; Kinetics; Luciferases; Membrane Proteins; Muscle, Smooth; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides; Trachea; Transforming Growth Factor beta; Up-Regulation; Vascular Endothelial Growth Factor A

2005
Cyclooxygenase-2 increases hypoxia-inducible factor-1 and vascular endothelial growth factor to promote angiogenesis in gastric carcinoma.
    Journal of biomedical science, 2005, Volume: 12, Issue:1

    Topics: Adult; Aged; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; DNA-Binding Proteins; Female; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Membrane Proteins; Middle Aged; Neovascularization, Pathologic; Nitrobenzenes; Nuclear Proteins; Prostaglandin-Endoperoxide Synthases; Signal Transduction; Stomach Neoplasms; Sulfonamides; Transcription Factors; Vascular Endothelial Growth Factor A

2005
Cyclooxygenase-1 mediates the final stage of morphine-induced delayed cardioprotection in concert with cyclooxygenase-2.
    Journal of the American College of Cardiology, 2005, May-17, Volume: 45, Issue:10

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cardiotonic Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Indomethacin; Ischemic Preconditioning, Myocardial; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Morphine; Myocardial Infarction; Myocardium; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Time Factors; Up-Regulation

2005
Resistance of prostate cancer cell lines to COX-2 inhibitor treatment.
    Biochemical and biophysical research communications, 2005, Jul-08, Volume: 332, Issue:3

    Topics: Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Resistance, Neoplasm; Humans; Immunohistochemistry; Male; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostatic Neoplasms; Sulfonamides

2005
Activation of the epidermal growth factor receptor in optic nerve astrocytes leads to early and transient induction of cyclooxygenase-2.
    Investigative ophthalmology & visual science, 2005, Volume: 46, Issue:6

    Topics: Animals; Astrocytes; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique, Indirect; Nitrobenzenes; Optic Nerve; Optic Nerve Injuries; Prostaglandin-Endoperoxide Synthases; Protein Tyrosine Phosphatases; Quinazolines; Rats; Rats, Wistar; Sulfonamides; Tyrphostins

2005
Stimulatory effects of eicosanoids on ovarian angiogenesis in early luteal phase in cyclooxygenase-2 inhibitor-treated rats.
    European journal of pharmacology, 2005, Jun-01, Volume: 516, Issue:2

    Topics: Animals; Choroid Plexus; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Eicosanoids; Female; Hemoglobins; Luteal Phase; Neovascularization, Physiologic; Nitrobenzenes; Ovary; Progesterone; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfonamides; Time Factors; Vascular Endothelial Growth Factor A

2005
Cyclooxygenase-2-dependent prostaglandin (PG) E2 downregulates matrix metalloproteinase-3 production via EP2/EP4 subtypes of PGE2 receptors in human periodontal ligament cells stimulated with interleukin-1alpha.
    Journal of periodontology, 2005, Volume: 76, Issue:6

    Topics: Analysis of Variance; Bucladesine; Cell Culture Techniques; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Down-Regulation; Humans; Indomethacin; Interleukin-1; Matrix Metalloproteinase 3; Membrane Proteins; Nitrobenzenes; Periodontal Ligament; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin E; Sulfonamides

2005
Hepatitis C virus stimulates the expression of cyclooxygenase-2 via oxidative stress: role of prostaglandin E2 in RNA replication.
    Journal of virology, 2005, Volume: 79, Issue:15

    Topics: Celecoxib; Cell Line, Tumor; Chelating Agents; Cyclooxygenase 2; Dinoprostone; Glycoproteins; Hepacivirus; Humans; Membrane Proteins; NF-kappa B; Nitrobenzenes; Oxidative Stress; Phosphatidylinositol 3-Kinases; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyrrolidines; Reactive Oxygen Species; Replicon; RNA, Viral; Sulfonamides; Thiocarbamates

2005
Interleukin-1beta-induced prostaglandin E2 production by human gingival fibroblasts is upregulated by glycine.
    Journal of periodontology, 2005, Volume: 76, Issue:7

    Topics: Analysis of Variance; Cell Proliferation; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Fibroblasts; Gingiva; Glycine; Humans; Indomethacin; Interleukin-1; Interleukin-10; Membrane Proteins; Nitrobenzenes; Periodontal Diseases; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Up-Regulation

2005
Mast cell tryptase stimulates DLD-1 carcinoma through prostaglandin- and MAP kinase-dependent manners.
    Journal of pharmacological sciences, 2005, Volume: 98, Issue:4

    Topics: Benzamidines; Calcium; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase Inhibitors; Cytosol; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Guanidines; Humans; Immunohistochemistry; Indomethacin; Mast Cells; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitrobenzenes; Phosphorylation; Prostaglandins; Receptor, PAR-2; Serine Endopeptidases; Sulfonamides; Tryptases

2005
Inhibition of cyclooxygenase-2 enhances myocardial damage in a mouse model of viral myocarditis.
    Life sciences, 2005, Nov-26, Volume: 78, Issue:2

    Topics: Adiponectin; Animals; Body Weight; Cardiovirus Infections; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Encephalomyocarditis virus; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocarditis; Myocardium; Myocytes, Cardiac; Nitrobenzenes; Organ Size; RNA, Messenger; Sulfonamides; Tumor Necrosis Factor-alpha

2005
Involvement of prostaglandins in an animal model of Shigella-related seizures.
    Journal of neuroimmunology, 2005, Volume: 168, Issue:1-2

    Topics: Animals; Chi-Square Distribution; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Nitrobenzenes; Pentylenetetrazole; Prostaglandin D2; Prostaglandins; Seizures; Shigella dysenteriae; Sulfonamides

2005
Prostaglandin E2 strongly inhibits human osteoclast formation.
    Endocrinology, 2005, Volume: 146, Issue:12

    Topics: Adult; Animals; Bone Marrow Cells; Carrier Proteins; Cell Differentiation; Cells, Cultured; Coculture Techniques; Culture Media; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; Lipopolysaccharide Receptors; Macrophages; Male; Membrane Glycoproteins; Mice; Middle Aged; Monocytes; Nitrobenzenes; Osteoclasts; Parathyroid Hormone; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Prostaglandin E; Sulfonamides

2005
Stimulation of prostaglandin E2 (PGE2) production by arachidonic acid, oestrogen and parathyroid hormone in MG-63 and MC3T3-E1 osteoblast-like cells.
    Prostaglandins, leukotrienes, and essential fatty acids, 2005, Volume: 73, Issue:6

    Topics: Animals; Arachidonic Acid; Cell Line; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Estradiol; Humans; Indomethacin; Mice; Nitrobenzenes; Osteoblasts; Osteosarcoma; Parathyroid Hormone; Prostaglandin-Endoperoxide Synthases; Sulfonamides

2005
Ionizing radiation induces astrocyte gliosis through microglia activation.
    Neurobiology of disease, 2006, Volume: 21, Issue:3

    Topics: Animals; Astrocytes; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Electrophoretic Mobility Shift Assay; Glial Fibrillary Acidic Protein; Gliosis; Immunoblotting; Immunohistochemistry; Mice; Microglia; Nitrobenzenes; Radiation, Ionizing; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides

2006
Radiation sensitivity of human carcinoma cells transfected with small interfering RNA targeted against cyclooxygenase-2.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Oct-01, Volume: 11, Issue:19 Pt 1

    Topics: Blotting, Western; Carcinoma; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Radiation; Gene Silencing; HeLa Cells; Humans; Immunoenzyme Techniques; Male; Nitrobenzenes; Prostaglandins; Prostatic Neoplasms; Radiation Tolerance; RNA Interference; RNA, Small Interfering; Sulfonamides; Transfection

2005
Celecoxib and NS-398 enhance photodynamic therapy by increasing in vitro apoptosis and decreasing in vivo inflammatory and angiogenic factors.
    Cancer research, 2005, Oct-15, Volume: 65, Issue:20

    Topics: Animals; Apoptosis; Celecoxib; Cyclooxygenase Inhibitors; Dihematoporphyrin Ether; Dinoprostone; Drug Synergism; Inflammation; Interleukin-1; Interleukin-10; Mammary Neoplasms, Experimental; Mice; Neovascularization, Pathologic; Nitrobenzenes; Photochemotherapy; Photosensitizing Agents; Pyrazoles; Sulfonamides; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A

2005
Peroxisome proliferator-activated receptor gamma mediates protection against cyclooxygenase-2-induced gut dysfunction in a rodent model of mesenteric ischemia/reperfusion.
    Shock (Augusta, Ga.), 2005, Volume: 24, Issue:5

    Topics: Active Transport, Cell Nucleus; Animals; Cell Nucleus; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cytoplasm; Cytosol; Dinoprostone; DNA; DNA Primers; Dose-Response Relationship, Drug; Gastrointestinal Tract; Inflammation; Intestine, Small; Ischemia; Male; Mesentery; Nitrobenzenes; Peroxidase; PPAR gamma; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Time Factors

2005
Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli.
    Journal of neurochemistry, 2005, Volume: 95, Issue:6

    Topics: Animals; Blood-Brain Barrier; Brain; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gene Expression; In Situ Hybridization; Indomethacin; Inflammation; Intramolecular Oxidoreductases; Ketorolac; Lipopolysaccharides; Male; Mice; Nitrobenzenes; Plasmids; Prostaglandin-E Synthases; Pyrazoles; Sulfonamides

2005
COX-2 mediates morphine-induced delayed cardioprotection via an iNOS-dependent mechanism.
    Life sciences, 2006, Apr-25, Volume: 78, Issue:22

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cardiotonic Agents; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Disease Models, Animal; Heart; Ischemic Preconditioning, Myocardial; Isothiuronium; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Morphine; Myocardial Infarction; Myocardium; Nitric Oxide Synthase Type II; Nitrobenzenes; Sulfonamides; Up-Regulation

2006
R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human nonpigmented ciliary epithelial cells.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:3

    Topics: Arachidonic Acids; Cannabinoids; Cells, Cultured; Cilia; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Dronabinol; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Humans; Matrix Metalloproteinases; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; RNA, Messenger; Sulfonamides; Tissue Inhibitor of Metalloproteinase-1

2006
Cyclooxygenase-2 (COX-2) is directly involved but not decisive in proliferation of human hepatocellular carcinoma cells.
    Journal of cancer research and clinical oncology, 2006, Volume: 132, Issue:3

    Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Electroporation; Flow Cytometry; Humans; Liver Neoplasms; Membrane Proteins; Nitrobenzenes; RNA, Small Interfering; Sulfonamides; Transfection

2006
Significance of COX-2 expression in human esophageal squamous cell carcinoma.
    Carcinogenesis, 2006, Volume: 27, Issue:6

    Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cyclooxygenase 2; Dinoprostone; Disease Progression; Esophageal Neoplasms; Esophagus; Female; Humans; Mice; Mice, Nude; Nitrobenzenes; RNA, Small Interfering; Sulfonamides

2006
alpha-Lipoic acid inhibits inflammatory bone resorption by suppressing prostaglandin E2 synthesis.
    Journal of immunology (Baltimore, Md. : 1950), 2006, Jan-01, Volume: 176, Issue:1

    Topics: Animals; Antioxidants; Blotting, Western; Bone and Bones; Bone Marrow Cells; Bone Resorption; Carrier Proteins; Cell Differentiation; Cells, Cultured; Coculture Techniques; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Inflammation; Interleukin-1; Macrophages; Membrane Glycoproteins; Mice; Mice, Inbred ICR; Nitrobenzenes; Osteoblasts; Osteoclasts; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Thioctic Acid

2006
Accelerative effect of a selective cyclooxygenase-2 inhibitor on Fas-mediated apoptosis in human neutrophils.
    International immunopharmacology, 2006, Volume: 6, Issue:3

    Topics: Apoptosis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytokines; Dinoprostone; Enzyme Induction; fas Receptor; Humans; Neutrophils; Nitrobenzenes; RNA, Messenger; Sulfonamides

2006
The immunosuppressive effects of ciprofloxacin during human mixed lymphocyte reaction.
    Clinical immunology (Orlando, Fla.), 2006, Volume: 119, Issue:1

    Topics: B7-1 Antigen; B7-2 Antigen; CD40 Antigens; CD40 Ligand; Cell Proliferation; Ciprofloxacin; Coculture Techniques; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Immunosuppressive Agents; Indomethacin; Intercellular Adhesion Molecule-1; Interferon-gamma; Interleukin-12; Interleukin-18; Isoquinolines; Leukocytes, Mononuclear; Lymphocyte Culture Test, Mixed; Lymphocytes; Monocytes; Nitrobenzenes; Protein Kinase Inhibitors; Sulfonamides; T-Lymphocytes

2006
Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells.
    Clinical immunology (Orlando, Fla.), 2006, Volume: 120, Issue:1

    Topics: B-Lymphocytes; Cell Growth Processes; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprost; Dinoprostone; Enzyme Activation; Humans; Immunoglobulin Heavy Chains; Immunohistochemistry; Indomethacin; Isoxazoles; Leukemia, Lymphocytic, Chronic, B-Cell; Nitrobenzenes; Pyrazoles; Sulfonamides; Sulfones; Thromboxane A2

2006
Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition.
    Journal of medicinal chemistry, 2006, Feb-23, Volume: 49, Issue:4

    Topics: Aniline Compounds; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Drug Screening Assays, Antitumor; Female; Humans; Microsomes; Neoplasms, Hormone-Dependent; Nitrobenzenes; Placenta; Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Transcription, Genetic

2006
Decidualization and maintenance of a functional prostaglandin system in human endometrial cell lines following transformation with SV40 large T antigen.
    Molecular human reproduction, 2006, Volume: 12, Issue:5

    Topics: Adult; Animals; Antigens, Polyomavirus Transforming; Cell Line; Cell Transformation, Viral; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Endometrium; Epithelial Cells; Female; Humans; Interleukin-1; Mice; Nitrobenzenes; Prostaglandins; Protein Biosynthesis; Receptors, Prostaglandin E; Receptors, Steroid; RNA, Messenger; Simian virus 40; Stromal Cells; Sulfonamides

2006
Lipoxin A(4) regulates bronchial epithelial cell responses to acid injury.
    The American journal of pathology, 2006, Volume: 168, Issue:4

    Topics: Bronchi; Cell Adhesion; Cell Proliferation; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Epithelial Cells; Gastric Acid; Humans; Hydrochloric Acid; Lipoxins; Membrane Proteins; Microscopy, Electron, Transmission; Nitrobenzenes; Receptors, Formyl Peptide; Receptors, Lipoxin; Respiratory Mucosa; Sulfonamides

2006
Transforming growth factor beta regulates cyclooxygenase-2 in glomerular mesangial cells.
    Kidney international, 2006, Volume: 69, Issue:9

    Topics: Animals; Collagen Type I; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Gene Expression Regulation, Enzymologic; Humans; Kidney Glomerulus; Mesangial Cells; NF-kappa B; Nitrobenzenes; Promoter Regions, Genetic; Prostaglandin-E Synthases; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; RNA Stability; RNA, Messenger; Sulfonamides; Transcription Factor AP-1; Transcription, Genetic; Transforming Growth Factor beta

2006
Role of bile acids, prostaglandins and COX inhibitors in chronic esophagitis in a mouse model.
    World journal of gastroenterology, 2006, Mar-21, Volume: 12, Issue:11

    Topics: Animals; Bile Acids and Salts; Chronic Disease; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Esophagitis, Peptic; Esophagus; Hydrochloric Acid; Indomethacin; Male; Mice; Mice, Inbred Strains; Mucous Membrane; Nitrobenzenes; Pepsin A; Prostaglandins; Radioimmunoassay; Severity of Illness Index; Sulfonamides

2006
Substance P stimulates release of RANKL via COX-2 expression in human dental pulp cells.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2006, Volume: 55, Issue:2

    Topics: Adolescent; Adult; Carrier Proteins; Cell Line; Cells, Cultured; Culture Media, Conditioned; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dental Pulp; Dinoprostone; Dose-Response Relationship, Drug; Female; Humans; Male; Membrane Glycoproteins; Membrane Proteins; Nitrobenzenes; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Substance P; Sulfonamides

2006
Cyclooxygenase inhibitors not inhibit resting lung cancer A549 cell proliferation.
    Prostaglandins, leukotrienes, and essential fatty acids, 2006, Volume: 74, Issue:5

    Topics: Antineoplastic Agents; Aspirin; Cell Proliferation; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Eicosanoic Acids; Humans; Isoenzymes; Lipopolysaccharides; Lung Neoplasms; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Tumor Cells, Cultured

2006
Enhanced early vascular permeability in gelatinase B (MMP-9)-deficient mice: putative contribution of COX-1-derived PGE2 of macrophage origin.
    Journal of leukocyte biology, 2006, Volume: 80, Issue:1

    Topics: Animals; Capillary Permeability; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Enzyme Activation; Macrophages; Male; Mast Cells; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Mice, Knockout; Nitrobenzenes; RNA; Structure-Activity Relationship; Sulfonamides; Time Factors

2006
Cyclooxygenase 2 induced by Kaposi's sarcoma-associated herpesvirus early during in vitro infection of target cells plays a role in the maintenance of latent viral gene expression.
    Journal of virology, 2006, Volume: 80, Issue:13

    Topics: Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Endothelial Cells; Fibroblasts; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Viral; Herpesviridae Infections; Herpesvirus 8, Human; Humans; Indomethacin; Inflammation; Membrane Proteins; Nitrobenzenes; Open Reading Frames; Promoter Regions, Genetic; Sulfonamides; Transcription, Genetic; Ultraviolet Rays; Up-Regulation; Viral Envelope Proteins; Virus Latency; Virus Replication

2006
Prostaglandin E2 produced by late induced COX-2 stimulates hippocampal neuron loss after seizure in the CA3 region.
    Neuroscience research, 2006, Volume: 56, Issue:1

    Topics: Animals; Cell Death; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Induction; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microinjections; Neurons; Nitrobenzenes; Rats; Rats, Wistar; Seizures; Sulfonamides

2006
Prostaglandin E2 release in gastric antral mucosa of guinea-pigs: basal PGE2 release by cyclo-oxygenase 2 and ACh-stimulated PGE2 release by cyclo-oxygenase 1.
    Experimental physiology, 2006, Volume: 91, Issue:6

    Topics: Acetylcholine; Animals; Arachidonic Acid; Aspirin; Calcium; Cinnamates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Mucosa; Guinea Pigs; Indomethacin; Ionomycin; Male; Nitrobenzenes; ortho-Aminobenzoates; Phospholipases A; Pyloric Antrum; Pyrazoles; Sulfonamides

2006
Endogenous prostaglandins E2 and F 2alpha serve as an anti-apoptotic factor against apoptosis induced by tumor necrosis factor-alpha in mouse 3T3-L1 preadipocytes.
    Bioscience, biotechnology, and biochemistry, 2006, Volume: 70, Issue:9

    Topics: 3T3-L1 Cells; Adipose Tissue; Animals; Antioxidants; Apoptosis; Calcimycin; Caspase 3; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprost; Dinoprostone; Ionophores; Mice; Nitrobenzenes; Prostaglandins; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sulfonamides; Tumor Necrosis Factor-alpha

2006
Cyclooxygenase inhibition and hyperthermia for the potentiation of the cytotoxic response in ovarian cancer cells.
    Gynecologic oncology, 2007, Volume: 104, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Docetaxel; Drug Synergism; Female; Humans; Hyperthermia, Induced; Nitrobenzenes; Ovarian Neoplasms; Sulfonamides; Taxoids; Tumor Cells, Cultured

2007
Involvement of cyclooxygenase-2--prostaglandin E2 pathway in interleukin-8 production in gastric cancer cells.
    Digestive diseases and sciences, 2006, Volume: 51, Issue:12

    Topics: Adenocarcinoma; Arachidonic Acid; Biphenyl Compounds; Cell Line, Tumor; Cyclic AMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Fibroblasts; Gene Expression Regulation, Neoplastic; Helicobacter pylori; Humans; Interleukin-8; Nitrobenzenes; Prostaglandin Antagonists; Receptors, Prostaglandin E; RNA, Messenger; Stomach Neoplasms; Sulfonamides; Xanthones

2006
Cyclooxygenase-2 inhibition suppresses alphavbeta6 integrin-dependent oral squamous carcinoma invasion.
    Cancer research, 2006, Nov-15, Volume: 66, Issue:22

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Neoplasm; Carcinoma, Squamous Cell; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Epithelial Cells; Humans; Integrins; Mice; Mice, Nude; Mouth Neoplasms; Neoplasm Invasiveness; Nitrobenzenes; Protein Binding; rac1 GTP-Binding Protein; Sulfonamides; Xenograft Model Antitumor Assays

2006
Bradykinin-induced nociceptor sensitisation to heat depends on cox-1 and cox-2 in isolated rat skin.
    Pain, 2007, Volume: 130, Issue:1-2

    Topics: Animals; Bradykinin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dermis; Dinoprostone; Hot Temperature; Immunohistochemistry; In Vitro Techniques; Male; Nerve Fibers, Unmyelinated; Neural Conduction; Nitrobenzenes; Nociceptors; Pyrazoles; Rats; Sulfonamides; Vasodilator Agents

2007
Arachidonic acid inhibits osteoblast differentiation through cytosolic phospholipase A2-dependent pathway.
    Oral diseases, 2007, Volume: 13, Issue:1

    Topics: 3T3 Cells; Alkaline Phosphatase; Animals; Arachidonic Acid; Arachidonic Acids; Cell Differentiation; Cell Shape; Clone Cells; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Dinoprostone; Enzyme Inhibitors; Fibroblasts; Indomethacin; Mice; Nitrobenzenes; Organophosphonates; Osteoblasts; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; RNA, Messenger; Sulfonamides

2007
An herbal medicine orengedokuto prevents indomethacin-induced enteropathy.
    Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Duodenal Ulcer; Female; Gastrointestinal Hemorrhage; Herbal Medicine; Indomethacin; Injections, Subcutaneous; Interleukin-10; Intestinal Mucosa; Intestine, Small; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Nitrobenzenes; Sulfonamides; Survival Analysis; Survival Rate; Treatment Outcome

2007
Screening method for nonsteroidal antiinflammatory drugs based on the cyclooxygenase 2 pathway activated by serum-free stimulation in A549 cells.
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2007, Volume: 127, Issue:3

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Culture Media, Serum-Free; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Immunoenzyme Techniques; Nitrobenzenes; Pyrazoles; Sulfonamides; Tumor Cells, Cultured

2007
Anti-inflammatory activity of the synthetic C-C biflavonoids.
    The Journal of pharmacy and pharmacology, 2006, Volume: 58, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biflavonoids; Blotting, Western; Carrageenan; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Edema; Lipopolysaccharides; Macrophages; Male; Mice; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrobenzenes; Prednisolone; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides

2006
Effect of a cyclooxygenase-2 inhibitor on interleukin-1beta-stimulated activation of the transcription factor nuclear factor-kappa B in human gingival fibroblasts.
    Journal of periodontology, 2007, Volume: 78, Issue:3

    Topics: Adolescent; Cell Line; Cell Nucleus; Cyclooxygenase 2 Inhibitors; Dinoprostone; Female; Fibroblasts; Gingiva; Humans; I-kappa B Proteins; Interleukin-1beta; Interleukin-6; NF-kappa B; Nitrobenzenes; Periodontitis; Phosphorylation; Sulfonamides; Transcription Factor RelA; Transcriptional Activation

2007
Regulation of COX-2 mediates acid-induced bone calcium efflux in vitro.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2007, Volume: 22, Issue:6

    Topics: Acidosis; Animals; Animals, Newborn; Bone and Bones; Bone Resorption; Calcium; Cells, Cultured; Culture Media; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Gene Expression; Genotype; Hydrogen-Ion Concentration; Immunoblotting; Membrane Proteins; Mice; Mice, Inbred Strains; Mice, Knockout; Nitrobenzenes; Organ Culture Techniques; Osteoblasts; RNA; Skull; Sulfonamides; Time Factors

2007
Strontium ranelate promotes osteoblastic differentiation and mineralization of murine bone marrow stromal cells: involvement of prostaglandins.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2007, Volume: 22, Issue:7

    Topics: Alkaline Phosphatase; Animals; Biomarkers; Bone Marrow Cells; Calcification, Physiologic; Cell Differentiation; Cells, Cultured; Cyclooxygenase 2; Dexamethasone; Dinoprostone; Female; Gene Expression Regulation, Enzymologic; Male; Mice; Nitrobenzenes; Organometallic Compounds; Osteoblasts; Stromal Cells; Sulfonamides; Thiophenes; Time Factors

2007
Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke.
    Circulation, 2007, Mar-27, Volume: 115, Issue:12

    Topics: Animals; Brain Chemistry; Brain Damage, Chronic; Cerebral Infarction; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Encephalitis; Gene Expression Regulation; Infarction, Middle Cerebral Artery; Inflammation Mediators; Interferon Regulatory Factor-1; Interferons; Interleukin-1beta; Lipid Peroxidation; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrobenzenes; Oxidative Stress; Sulfonamides; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2007
Long-term fenofibrate treatment impairs endothelium-dependent dilation to acetylcholine by altering the cyclooxygenase pathway.
    Cardiovascular research, 2007, Jul-15, Volume: 75, Issue:2

    Topics: Acetylcholine; Animals; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Endothelium, Vascular; Fenofibrate; In Vitro Techniques; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins F; Rats; Rats, Wistar; Sulfonamides; Time Factors; Vasodilation; Vasodilator Agents

2007
Normal or stress-induced fibroblast senescence involves COX-2 activity.
    Experimental cell research, 2007, Aug-15, Volume: 313, Issue:14

    Topics: Animals; Cells, Cultured; Cellular Senescence; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Fibroblasts; Gene Silencing; Humans; Hydrogen Peroxide; NF-kappa B; Nitrobenzenes; Oxidants; Oxidative Stress; Proto-Oncogene Proteins c-rel; Sulfonamides

2007
Abnormalities of prostaglandins and cyclooxygenase enzymes in female patients with slow-transit constipation.
    Gastroenterology, 2007, Volume: 133, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Chronic Disease; Colon; Constipation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Female; Gastrointestinal Motility; Gastrointestinal Transit; Humans; Membrane Proteins; Middle Aged; Muscle, Smooth; Nitrobenzenes; Progesterone; Prostaglandins; Pyrazoles; Receptors, Progesterone; RNA, Messenger; Sulfonamides; Thromboxane A2; Up-Regulation

2007
Cyclooxygenase-2 inhibitors demonstrate anti-proliferative effects in oesophageal cancer cells by prostaglandin E(2)-independent mechanisms.
    Cancer letters, 2007, Oct-28, Volume: 256, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Shape; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Esophageal Neoplasms; Humans; Mitochondrial Membranes; Nitrobenzenes; Sulfonamides; Time Factors

2007
Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension.
    World journal of gastroenterology, 2007, Oct-14, Volume: 13, Issue:38

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Portal; Lasers; Leukotriene B4; Male; Nitrobenzenes; Platelet Activation; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Thrombosis; Thromboxane B2

2007
Inhibition of COX-2 with NS-398 decreases colon cancer cell motility through blocking epidermal growth factor receptor transactivation: possibilities for combination therapy.
    Cell proliferation, 2007, Volume: 40, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Base Sequence; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Cyclooxygenase 2 Inhibitors; Dinoprostone; DNA Primers; ErbB Receptors; Humans; Nitrobenzenes; Phosphorylation; Sulfonamides; Transcriptional Activation

2007
Role of prostaglandins in collecting duct-derived endothelin-1 regulation of blood pressure and water excretion.
    American journal of physiology. Renal physiology, 2007, Volume: 293, Issue:6

    Topics: Animals; Blood Pressure; Blotting, Western; Cyclic AMP; Cyclooxygenase Inhibitors; Dinoprostone; Endothelin-1; Indomethacin; Kidney Medulla; Kidney Tubules, Collecting; Mice; Mice, Knockout; Mice, Transgenic; Nitrobenzenes; Osmolar Concentration; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Renal Agents; Sodium; Sulfonamides; Telemetry; Vasopressins; Water

2007
Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells.
    Experimental & molecular medicine, 2007, Aug-31, Volume: 39, Issue:4

    Topics: Bone Neoplasms; Celecoxib; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Enzyme Activation; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Nitrobenzenes; Osteosarcoma; Pyrazoles; Sulfonamides

2007
Microparticles stimulate the synthesis of prostaglandin E(2) via induction of cyclooxygenase 2 and microsomal prostaglandin E synthase 1.
    Arthritis and rheumatism, 2007, Volume: 56, Issue:11

    Topics: Arachidonic Acids; Arthritis, Rheumatoid; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Fibroblasts; Humans; Intramolecular Oxidoreductases; JNK Mitogen-Activated Protein Kinases; Microsomes; Monocytes; NF-kappa B; Nitrobenzenes; Osteoarthritis; Particle Size; Prostaglandin-E Synthases; Signal Transduction; Sulfonamides; Synovial Fluid; T-Lymphocytes; Transcription Factor AP-1; Up-Regulation

2007
Effect of etidronate on COX-2 expression and PGE(2) production in macrophage-like RAW 264.7 cells stimulated by titanium particles.
    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2007, Volume: 12, Issue:6

    Topics: Animals; Bone Resorption; Cell Survival; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Etidronic Acid; Gene Expression; Interleukin-1beta; Interleukin-6; Macrophages; Mice; Nitrobenzenes; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Titanium; Tumor Necrosis Factor-alpha

2007
Cannabinoids stimulate prostaglandin production by human gestational tissues through a tissue- and CB1-receptor-specific mechanism.
    American journal of physiology. Endocrinology and metabolism, 2008, Volume: 294, Issue:2

    Topics: Adult; Amnion; Blotting, Western; Cannabinoid Receptor Modulators; Chorion; Cyclohexanols; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Decidua; Dinoprostone; Female; Humans; In Vitro Techniques; Nitrobenzenes; Piperidines; Placenta; Pregnancy; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Rimonabant; Sulfonamides

2008
Fluid secretion caused by aerolysin-like hemolysin of Aeromonas sobria in the intestines is due to stimulation of production of prostaglandin E2 via cyclooxygenase 2 by intestinal cells.
    Infection and immunity, 2008, Volume: 76, Issue:3

    Topics: Aeromonas; Animals; Blotting, Western; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cystic Fibrosis Transmembrane Conductance Regulator; Dinoprostone; Enzyme Inhibitors; Exudates and Transudates; Glyburide; Hemolysin Proteins; Intestinal Mucosa; Intestine, Small; Isoquinolines; Male; Mice; Nitrobenzenes; Protein Kinase Inhibitors; Sulfonamides

2008
Induction of prostaglandin E2 synthesis and microsomal prostaglandin E synthase-1 expression in murine microglia by glioma-derived soluble factors. Laboratory investigation.
    Journal of neurosurgery, 2008, Volume: 108, Issue:2

    Topics: Animals; Blotting, Western; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Female; Glioma; Intramolecular Oxidoreductases; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Microglia; Microsomes; Nitrobenzenes; Prostaglandin-E Synthases; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Tumor Necrosis Factor-alpha

2008
The COX-2 selective inhibitor-independent COX-2 effect on colon carcinoma cells is associated with the Delta1/Notch1 pathway.
    Digestive diseases and sciences, 2008, Volume: 53, Issue:8

    Topics: Amyloid Precursor Protein Secretases; Antineoplastic Agents; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; Cell Proliferation; Colonic Neoplasms; Colorimetry; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dipeptides; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Homeodomain Proteins; HT29 Cells; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Membrane Proteins; NF-kappa B p52 Subunit; Nitrobenzenes; Receptor, Notch1; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sulfonamides; Time Factors; Transcription Factor HES-1

2008
The cyclooxygenase-2/prostaglandin E2 pathway is involved in the somatostatin-induced decrease of epileptiform bursting in the mouse hippocampus.
    Neuropharmacology, 2008, Volume: 54, Issue:5

    Topics: 4-Aminopyridine; Animals; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Epilepsy; Female; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Nitrobenzenes; Potassium Channel Blockers; RNA, Messenger; Signal Transduction; Somatostatin; Sulfonamides

2008
Inhibition of cyclooxygenase-2 aggravates secretory phospholipase A2-mediated progression of acute liver injury.
    Toxicology and applied pharmacology, 2008, Apr-15, Volume: 228, Issue:2

    Topics: Acute Disease; Alanine Transaminase; Animals; Blotting, Western; Carbon Radioisotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Corn Oil; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytochrome P-450 CYP2E1; Dinoprostone; Disease Progression; Drug Synergism; Liver; Male; Microsomes, Liver; Nitrobenzenes; Nitrophenols; Phospholipases A2, Secretory; Rats; Rats, Inbred F344; Sulfonamides; Survival Rate

2008
Cyclooxygenase-2 induction by lysophosphatidylcholine in cultured rat vascular smooth muscle cells: involvement of the p38MAPK pathway.
    Biomedical research (Tokyo, Japan), 2008, Volume: 29, Issue:1

    Topics: Animals; Cells, Cultured; Culture Media, Serum-Free; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Flavonoids; Imidazoles; Lysophosphatidylcholines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfonamides

2008
VEGF expression and the effect of NSAIDs on ascites cell proliferation in the hen model of ovarian cancer.
    Gynecologic oncology, 2008, Volume: 110, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ascites; Aspirin; Cell Growth Processes; Chickens; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Female; Nitrobenzenes; Ovarian Neoplasms; RNA, Messenger; Sulfonamides; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A

2008
Induction of apoptosis and cell cycle arrest by NS398 in oral squamous cell carcinoma cells via downregulation of E2 promoter-binding factor-1.
    Oncology reports, 2008, Volume: 20, Issue:3

    Topics: Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Caspase 3; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Down-Regulation; E2F1 Transcription Factor; Flow Cytometry; G1 Phase; Humans; Immunoenzyme Techniques; Mouth Mucosa; Mouth Neoplasms; Nitrobenzenes; Sulfonamides; Tumor Cells, Cultured

2008
Heterotypic contact reveals a COX-2-mediated suppression of osteoblast differentiation by endothelial cells: A negative modulatory role for prostanoids in VEGF-mediated cell: cell communication?
    Experimental cell research, 2008, Oct-15, Volume: 314, Issue:17

    Topics: 6-Ketoprostaglandin F1 alpha; Alkaline Phosphatase; Animals; Cell Communication; Cell Differentiation; Cells, Cultured; Coculture Techniques; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Humans; Nitrobenzenes; Osteoblasts; Prostaglandins; Sulfonamides; Vascular Endothelial Growth Factor Receptor-2

2008
Prevention of both direct and cross-priming of antitumor CD8+ T-cell responses following overproduction of prostaglandin E2 by tumor cells in vivo.
    Cancer research, 2008, Sep-15, Volume: 68, Issue:18

    Topics: Animals; Carcinoma, Renal Cell; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cross-Priming; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dendritic Cells; Dinoprostone; Humans; Interleukin-10; Kidney Neoplasms; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Nitrobenzenes; Receptors, Interleukin-10; Sulfonamides

2008
NS-398, a selective COX-2 inhibitor, inhibits proliferation of IL-1beta-stimulated vascular smooth muscle cells by induction of HO-1.
    Biochemical and biophysical research communications, 2008, Nov-28, Volume: 376, Issue:4

    Topics: Animals; Cell Proliferation; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Dinoprostone; Heme Oxygenase-1; Interleukin-1beta; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitrobenzenes; Rats; Rats, Sprague-Dawley; Sulfonamides

2008
Determination of prostaglandin E(2) by on-line solid-phase extraction-liquid chromatography with ultraviolet detection for microsomal prostaglandin E(2) synthase-1 inhibitor screening.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, Nov-15, Volume: 875, Issue:2

    Topics: Alprostadil; Cell Line, Tumor; Chromatography, Liquid; Cyclooxygenase Inhibitors; Dinoprostone; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Intramolecular Oxidoreductases; Kinetics; Microsomes; Nitrobenzenes; Prostaglandin H2; Prostaglandin-E Synthases; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Sulfonamides

2008
Effects of nicotine and lipopolysaccharide on the expression of matrix metalloproteinases, plasminogen activators, and their inhibitors in human osteoblasts.
    Archives of oral biology, 2009, Volume: 54, Issue:2

    Topics: Alkaline Phosphatase; Celecoxib; Cell Proliferation; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Gene Expression Regulation; Humans; Lipopolysaccharides; Matrix Metalloproteinase 1; Matrix Metalloproteinases; Nicotine; Nicotinic Antagonists; Nitrobenzenes; Osteoblasts; Plasminogen Activators; Plasminogen Inactivators; Polymyxin B; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Tubocurarine

2009
Altered hippocampal long-term synaptic plasticity in mice deficient in the PGE2 EP2 receptor.
    Journal of neurochemistry, 2009, Volume: 108, Issue:1

    Topics: Alprostadil; Animals; Animals, Newborn; Colforsin; Cyclooxygenase Inhibitors; Dinoprostone; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Maze Learning; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Neurons; Nitrobenzenes; Patch-Clamp Techniques; Physical Phenomena; Reaction Time; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Signal Transduction; Sulfonamides; Synapses; Time Factors

2009
R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway.
    Pharmaceutical research, 2009, Volume: 26, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Arachidonic Acids; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; DNA Fragmentation; Dose-Response Relationship, Drug; Female; Fumonisins; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Intramolecular Oxidoreductases; Lipocalins; Nitrobenzenes; Oxidoreductases; PPAR gamma; Prostaglandin D2; RNA Interference; RNA, Messenger; RNA, Small Interfering; Sulfonamides; Time Factors; Uterine Cervical Neoplasms

2009
Induction of prostacyclin by steady laminar shear stress suppresses tumor necrosis factor-alpha biosynthesis via heme oxygenase-1 in human endothelial cells.
    Circulation research, 2009, Feb-27, Volume: 104, Issue:4

    Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Atherosclerosis; Benzofurans; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Down-Regulation; Endothelial Cells; Epoprostenol; Heme Oxygenase-1; Humans; Inflammation; Nitrobenzenes; Perfusion; Propionates; Prostaglandin D2; Receptors, Epoprostenol; Receptors, Prostaglandin; Stress, Mechanical; Sulfonamides; Tumor Necrosis Factor-alpha; Up-Regulation

2009
In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E(2) biosynthesis.
    Archives of pharmacal research, 2009, Volume: 32, Issue:1

    Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cymenes; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Monoterpenes; Nitrobenzenes; Sheep; Sulfonamides

2009
NS398 protects cells from sodium nitroprusside-mediated cytotoxicity through enhancing HO-1 induction independent of COX-2 inhibition.
    Archives of pharmacal research, 2009, Volume: 32, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytoprotection; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Heme Oxygenase-1; Macrophages; Membrane Proteins; Mice; Nitrobenzenes; Nitroprusside; Oxidative Stress; RNA Interference; RNA, Small Interfering; Signal Transduction; Sulfonamides; Time Factors

2009
Identification of novel cyclooxygenase-2-dependent genes in Helicobacter pylori infection in vivo.
    Molecular cancer, 2009, Mar-24, Volume: 8

    Topics: Animals; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Gastric Mucosa; Gene Expression Profiling; Helicobacter Infections; Helicobacter pylori; Mice; Nitrobenzenes; Sulfonamides; Up-Regulation

2009
Effects of global or targeted deletion of the EP4 receptor on the response of osteoblasts to prostaglandin in vitro and on bone histomorphometry in aged mice.
    Bone, 2009, Volume: 45, Issue:1

    Topics: Aging; Animals; Body Composition; Bone and Bones; Breeding; Cells, Cultured; Dinoprostone; Female; Gene Deletion; Genotype; Heterozygote; Male; Mice; Nitrobenzenes; Osteoblasts; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Sulfonamides; Survival Rate; Weaning

2009
Involvement of PGE2 and PGDH but not COX-2 in thrombin-induced cortical neuron apoptosis.
    Neuroscience letters, 2009, Mar-13, Volume: 452, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cells, Cultured; Cerebral Cortex; Cyclooxygenase 2; Dinoprostone; Encephalitis; Hydroxyprostaglandin Dehydrogenases; Nerve Degeneration; Neurons; Nitrobenzenes; Rats; Sulfonamides; Thrombin

2009
MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2.
    Blood, 2009, Jun-25, Volume: 113, Issue:26

    Topics: Antigens, CD; Cell Differentiation; Child; Coculture Techniques; Dendritic Cells; Dinoprostone; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-4; Interleukin-6; Lipopolysaccharides; Lymphocyte Activation; Macrophage Colony-Stimulating Factor; Mesenchymal Stem Cells; Monocytes; Nitrobenzenes; Prostaglandin Antagonists; Sulfonamides; T-Lymphocytes

2009
Role of prostanoid production and receptors in the regulation of retinal endogenous amino acid neurotransmitters by 8-isoprostaglandin E2, ex vivo.
    Neurochemical research, 2009, Volume: 34, Issue:12

    Topics: Animals; Benzofurans; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cyclooxygenase Inhibitors; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dinoprostone; Fatty Acids, Unsaturated; Flurbiprofen; Glutamic Acid; Glutamine; Glycine; Hydrazines; Isoprostanes; Neurotransmitter Agents; Nitrobenzenes; Prostaglandins; Receptors, Prostaglandin; Retina; Sulfonamides; Xanthones

2009
Ovariectomy increases the formation of prostanoids and modulates their role in acetylcholine-induced relaxation and nitric oxide release in the rat aorta.
    Cardiovascular research, 2009, Nov-01, Volume: 84, Issue:2

    Topics: Acetylcholine; Animals; Aorta; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Epoprostenol; Fatty Acids, Unsaturated; Female; Hydrazines; Intramolecular Oxidoreductases; Membrane Proteins; Nitric Oxide; Nitrobenzenes; Ovariectomy; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Tranylcypromine; Vasodilation; Vasodilator Agents

2009
15-hydroxyprostaglandin dehydrogenase is down-regulated in gastric cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Jul-15, Volume: 15, Issue:14

    Topics: Azacitidine; Cell Line, Tumor; Cell Proliferation; CpG Islands; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Decitabine; Dinoprostone; DNA Methylation; Down-Regulation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydroxyprostaglandin Dehydrogenases; Immunohistochemistry; Interleukin-1beta; Nitrobenzenes; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Stomach Neoplasms; Sulfonamides; Transfection

2009
The effect of linolenic Acid on bovine oocyte maturation and development.
    Biology of reproduction, 2009, Volume: 81, Issue:6

    Topics: alpha-Linolenic Acid; Analysis of Variance; Animals; Blastocyst; Blotting, Western; Butadienes; Cattle; Cells, Cultured; Cumulus Cells; Cyclic AMP; Dinoprostone; Embryo Culture Techniques; Embryonic Development; Enzyme Inhibitors; Female; Fertilization in Vitro; Immunoenzyme Techniques; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Nitrobenzenes; Oocytes; Oogenesis; Phosphorylation; Proto-Oncogene Proteins c-akt; Radioimmunoassay; Sulfonamides; Time Factors

2009
Lipopolysaccharide promoted proliferation and invasion of endometriotic stromal cells via induction of cyclooxygenase-2 expression.
    Fertility and sterility, 2010, Volume: 93, Issue:1

    Topics: Case-Control Studies; Cell Movement; Cell Proliferation; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Endometriosis; Endometrium; Enzyme Induction; Female; Humans; Lipopolysaccharides; Nitrobenzenes; Ovarian Diseases; RNA Interference; RNA, Messenger; Stromal Cells; Sulfonamides; Time Factors

2010
Enhanced 5-fluorouracil cytotoxicity in high cyclooxygenase-2 expressing colorectal cancer cells and xenografts induced by non-steroidal anti-inflammatory drugs via downregulation of dihydropyrimidine dehydrogenase.
    Cancer chemotherapy and pharmacology, 2010, Volume: 66, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Collagen; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dihydrouracil Dehydrogenase (NADP); Dinoprostone; Down-Regulation; Drug Interactions; Extracellular Matrix; Fluorescent Antibody Technique; Fluorouracil; HT29 Cells; Humans; Indomethacin; Nitrobenzenes; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Xenograft Model Antitumor Assays

2010
Wogonin inhibits osteoclast formation induced by lipopolysaccharide.
    Phytotherapy research : PTR, 2010, Volume: 24, Issue:7

    Topics: Animals; Bone Resorption; Cell Differentiation; Cells, Cultured; Coculture Techniques; Cyclooxygenase Inhibitors; Dinoprostone; Drugs, Chinese Herbal; Flavanones; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Nitrobenzenes; Osteoclasts; Osteoprotegerin; RANK Ligand; Sulfonamides

2010
The role of TNF-alpha signaling pathway on COX-2 upregulation and cognitive decline induced by beta-amyloid peptide.
    Behavioural brain research, 2010, May-01, Volume: 209, Issue:1

    Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Antibodies; Cognition Disorders; CREB-Binding Protein; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Hippocampus; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrobenzenes; Peptide Fragments; Protein Kinase C; Receptors, Tumor Necrosis Factor, Type I; Recognition, Psychology; Signal Transduction; Sulfonamides; Tumor Necrosis Factor-alpha; Up-Regulation

2010
Lipopolysaccharide induces calcitonin gene-related peptide in the RAW264.7 macrophage cell line.
    Immunology, 2010, Volume: 130, Issue:3

    Topics: Animals; Antibodies; Calcitonin Gene-Related Peptide; Calcitonin Receptor-Like Protein; Cell Line; Chemokines; Cycloheximide; Cyclooxygenase 2 Inhibitors; Cytokines; Dactinomycin; Dinoprostone; Enzyme Inhibitors; I-kappa B Proteins; Interleukin-1beta; Interleukin-6; Intracellular Signaling Peptides and Proteins; Kinetics; Lipopolysaccharides; Macrophages; Membrane Proteins; Mice; Nerve Growth Factor; Nitriles; Nitrobenzenes; Peptide Fragments; Piperazines; Quinazolines; Receptor Activity-Modifying Proteins; Receptor, trkA; Receptors, Calcitonin; Sulfonamides; Sulfones; Toll-Like Receptor 4

2010
Hyaluronan inhibits prostaglandin E2 production via CD44 in U937 human macrophages.
    The Tohoku journal of experimental medicine, 2010, Volume: 220, Issue:3

    Topics: Animals; Arthritis, Rheumatoid; Cell Line; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Down-Regulation; Humans; Hyaluronan Receptors; Hyaluronic Acid; Lipopolysaccharides; Macrophages; NF-kappa B; Nitriles; Nitrobenzenes; Sulfonamides; Sulfones; U937 Cells

2010
Prostaglandin-E2 is produced by adult human epidermal melanocytes in response to UVB in a melanogenesis-independent manner.
    Pigment cell & melanoma research, 2010, Volume: 23, Issue:3

    Topics: Adult; Arachidonic Acid; Dinoprostone; Epidermal Cells; Female; Humans; Hydrogen Peroxide; Indomethacin; Intramolecular Oxidoreductases; Keratinocytes; Male; Melanins; Melanocytes; Membrane Glycoproteins; Monophenol Monooxygenase; Nitrobenzenes; Oxidoreductases; Sulfonamides; Ultraviolet Rays; Young Adult

2010
Human beta-defensin-3 up-regulates cyclooxygenase-2 expression and prostaglandin E2 synthesis in human gingival fibroblasts.
    Journal of periodontal research, 2010, Volume: 45, Issue:4

    Topics: beta-Defensins; Cell Culture Techniques; Cells, Cultured; Culture Media, Conditioned; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Fibroblasts; Gingiva; Humans; Inflammation Mediators; Interleukin-1beta; L-Lactate Dehydrogenase; Nitrobenzenes; Sulfonamides; Time Factors; Up-Regulation

2010
TGF-beta1 reverses inhibition of COX-2 with NS398 and increases invasion in prostate cancer cells.
    The American journal of the medical sciences, 2010, Volume: 339, Issue:5

    Topics: Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Humans; Male; Neoplasm Invasiveness; Nitrobenzenes; Prostate; Prostatic Neoplasms; Sulfonamides; Transforming Growth Factor beta1

2010
Stimulatory effects of areca nut extracts on prostaglandin E2 production by human polymorphonuclear leukocytes.
    Journal of periodontology, 2010, Volume: 81, Issue:5

    Topics: Adult; Areca; Blotting, Western; Butadienes; Calcium; Cell Survival; Cells, Cultured; Chelating Agents; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Imidazoles; Inflammation Mediators; Male; Neutrophils; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Pyridines; Sulfonamides; Young Adult

2010
Resolution of inflammation in murine autoimmune arthritis is disrupted by cyclooxygenase-2 inhibition and restored by prostaglandin E2-mediated lipoxin A4 production.
    Journal of immunology (Baltimore, Md. : 1950), 2010, Jun-01, Volume: 184, Issue:11

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Inflammation; Inflammation Mediators; Lipoxins; Male; Mice; Nitrobenzenes; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides

2010
Inhibitory effect of vitamin K(2) on interleukin-1beta-stimulated proliferation of human osteoblasts.
    Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:5

    Topics: Adult; Anticoagulants; Bone Neoplasms; Cell Line; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Flavonoids; Glutamic Acid; Humans; Imidazoles; Interleukin-1; Interleukin-1beta; Male; Mitogen-Activated Protein Kinase Kinases; Nitrobenzenes; Osteoblasts; Osteocalcin; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; Pregnane X Receptor; Protein Kinase Inhibitors; Pyridines; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Sulfonamides; Vitamin K; Vitamins; Warfarin; Young Adult

2010
Celecoxib increases retinoid sensitivity in human colon cancer cell lines.
    Cellular & molecular biology letters, 2010, Volume: 15, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Celecoxib; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase 2 Inhibitors; Dinoprostone; HT29 Cells; Humans; Nitrobenzenes; Pyrazoles; Receptors, Retinoic Acid; Sulfonamides; Tretinoin

2010
Targeting the tumor microenvironment using photodynamic therapy combined with inhibitors of cyclooxygenase-2 or vascular endothelial growth factor.
    Methods in molecular biology (Clifton, N.J.), 2010, Volume: 635

    Topics: Animals; Celecoxib; Cell Line, Tumor; Cell Transformation, Neoplastic; Combined Modality Therapy; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dihematoporphyrin Ether; Dinoprostone; Female; Humans; Injections; Light; Mice; Neoplasms; Nitrobenzenes; Photochemotherapy; Pyrazoles; Skin; Sulfonamides; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2010
Modulation of the cyclooxygenase pathway via inhibition of nitric oxide production contributes to the anti-inflammatory activity of kaempferol.
    European journal of pharmacology, 2010, Sep-10, Volume: 642, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Colchicine; Dexamethasone; Dinoprostone; Exudates and Transudates; Inflammation; Kaempferols; Lysine; Male; Nitric Oxide; Nitrites; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfonamides

2010
The effect of the expression of angiotensin II on extracellular matrix metalloproteinase inducer (EMMPRIN) in macrophages is mediated via the AT1/COX-2/PGE2 pathway.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010, Volume: 59, Issue:12

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Basigin; Cell Line; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Imidazoles; Losartan; Macrophages; Nitrobenzenes; Pyridines; Receptor, Angiotensin, Type 1; Signal Transduction; Sulfonamides

2010
Pro-inflammatory effects of commercial alpha-lactalbumin on RAW 264.7 macrophages is due to endotoxin contamination.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010, Volume: 48, Issue:10

    Topics: Animals; Blotting, Western; Cell Survival; Cyclooxygenase 2; Dinoprostone; Drug Contamination; Endotoxins; Enzyme Inhibitors; Fluorescent Antibody Technique; Immunologic Factors; Inflammation; Lactalbumin; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrobenzenes; Phosphorylation; Signal Transduction; Sulfonamides

2010
Inducible cyclooxygenase released prostaglandin E2 modulates the severity of infection caused by Streptococcus pyogenes.
    Journal of immunology (Baltimore, Md. : 1950), 2010, Aug-15, Volume: 185, Issue:4

    Topics: Animals; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Female; Host-Pathogen Interactions; Humans; Immunohistochemistry; Macrophages; Mice; Mice, Inbred C3H; Mice, Knockout; Nitrobenzenes; Prostaglandin Antagonists; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Severity of Illness Index; Streptococcal Infections; Streptococcus pyogenes; Sulfonamides; Xanthones

2010
Amyloid-β induces cyclooxygenase-2 and PGE2 release in human astrocytes in NF-κ B dependent manner.
    Journal of Alzheimer's disease : JAD, 2010, Volume: 22, Issue:2

    Topics: Amyloid beta-Peptides; Astrocytes; Cell Survival; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Luciferases; NF-kappa B; Nitrobenzenes; Peptide Fragments; Proline; RNA, Messenger; Sulfonamides; Thiocarbamates; Transfection

2010
Kainic acid-induced neurodegeneration and activation of inflammatory processes in organotypic hippocampal slice cultures: treatment with cyclooxygenase-2 inhibitor does not prevent neuronal death.
    Neuropharmacology, 2011, Volume: 60, Issue:7-8

    Topics: Animals; Cell Culture Techniques; Cell Death; Cyclooxygenase 2 Inhibitors; Dinoprostone; Excitatory Amino Acid Agonists; Hippocampus; Inflammation; Kainic Acid; Male; Nerve Degeneration; Neurons; Nitrobenzenes; Rats; Rats, Sprague-Dawley; Sulfonamides

2011
Pathophysiology of motility dysfunction in bowel obstruction: role of stretch-induced COX-2.
    American journal of physiology. Gastrointestinal and liver physiology, 2011, Volume: 300, Issue:1

    Topics: Animals; Colon; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Gastrointestinal Motility; Intestinal Obstruction; Male; Mice; Muscle Contraction; Muscle, Smooth; Nitrobenzenes; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Sulfonamides

2011
Prevotella intermedia induces prostaglandin E2 via multiple signaling pathways.
    Journal of dental research, 2011, Volume: 90, Issue:1

    Topics: Cell Culture Techniques; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Humans; Indomethacin; JNK Mitogen-Activated Protein Kinases; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Phosphoinositide-3 Kinase Inhibitors; Prevotella intermedia; Protein Kinase C; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; Sulfonamides; Time Factors

2011
Houttuynia cordata, a novel and selective COX-2 inhibitor with anti-inflammatory activity.
    Journal of ethnopharmacology, 2011, Jan-27, Volume: 133, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Base Sequence; China; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; DNA Primers; Drugs, Chinese Herbal; Ethnopharmacology; Female; Houttuynia; In Vitro Techniques; Macrophages, Peritoneal; Medicine, Chinese Traditional; Membrane Proteins; Mice; Nitrobenzenes; Plants, Medicinal; RNA, Messenger; Sulfonamides

2011
Tumor-secreted PGE2 inhibits CCL5 production in activated macrophages through cAMP/PKA signaling pathway.
    The Journal of biological chemistry, 2011, Jan-21, Volume: 286, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Infections; Cell Line; Chemokine CCL5; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Interferon-gamma; Interleukin-2; Isoquinolines; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Nitrobenzenes; Prostaglandin Antagonists; Protein Kinase Inhibitors; Shock, Septic; Signal Transduction; Sulfonamides; Tumor Escape; Xanthones

2011
Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes.
    The Journal of general virology, 2011, Volume: 92, Issue:Pt 3

    Topics: Astrocytes; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytokines; Dinoprostone; Gene Expression; Humans; Inflammation Mediators; Nitrobenzenes; RNA, Messenger; Sulfonamides; West Nile virus

2011
Vitamin C down-regulates VEGF production in B16F10 murine melanoma cells via the suppression of p42/44 MAPK activation.
    Journal of cellular biochemistry, 2011, Volume: 112, Issue:3

    Topics: Animals; Ascorbic Acid; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Down-Regulation; Enzyme Activation; Melanoma, Experimental; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitrobenzenes; Phosphorylation; Sulfonamides; Vascular Endothelial Growth Factor A

2011
[Celecoxib increased cellular ATRA sensitivity of human colon cancer cell lines through COX-2-independent mechanisms].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2009, Volume: 44, Issue:12

    Topics: Antineoplastic Agents; Apoptosis; Celecoxib; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Drug Synergism; HT29 Cells; Humans; Nitrobenzenes; Pyrazoles; Receptors, Retinoic Acid; Sulfonamides; Tretinoin

2009
Role of prostaglandin E2 in the synthesis of the pro-inflammatory cytokine interleukin-6 in primary sensory neurons: an in vivo and in vitro study.
    Journal of neurochemistry, 2011, Volume: 118, Issue:5

    Topics: Analysis of Variance; Animals; Biphenyl Compounds; CREB-Binding Protein; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Ganglia, Spinal; Interleukin-6; Male; NF-kappaB-Inducing Kinase; Nitrobenzenes; Organ Culture Techniques; Pain Measurement; Pain Threshold; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Prostaglandin E, EP4 Subtype; Sciatic Neuropathy; Sensory Receptor Cells; Signal Transduction; Sulfonamides; Time Factors; Up-Regulation

2011
Interleukin-6 and soluble interleukin-6 receptor suppress osteoclastic differentiation by inducing PGE(2) production in chondrocytes.
    Journal of oral science, 2011, Volume: 53, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bone Resorption; Carbonic Anhydrase II; Cathepsin K; Cell Differentiation; Cells, Cultured; Chondrocytes; Cyclooxygenase 2; Dinoprostone; Gene Expression; Humans; Interleukin-6; Macrophage Colony-Stimulating Factor; Matrix Metalloproteinase 9; Nitrobenzenes; Osteoclasts; Osteoprotegerin; Prostaglandin-Endoperoxide Synthases; RANK Ligand; Receptors, Interleukin-6; Sulfonamides

2011
Evidence that PGE2 in the dorsal and median raphe nuclei is involved in LPS-induced anorexia in rats.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 99, Issue:3

    Topics: Animals; Anorexia; Cyclooxygenase 2 Inhibitors; Dinoprostone; Injections, Intraventricular; Lipopolysaccharides; Male; Mesencephalon; Nitrobenzenes; Raphe Nuclei; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Sulfonamides

2011
Positive feedback loop between prostaglandin E2 and EGF-like factors is essential for sustainable activation of MAPK3/1 in cumulus cells during in vitro maturation of porcine cumulus oocyte complexes.
    Biology of reproduction, 2011, Volume: 85, Issue:5

    Topics: Animals; Cell Communication; Cells, Cultured; Cumulus Cells; Cyclic AMP; Cyclooxygenase 2; Dinoprostone; Epidermal Growth Factor; Feedback, Physiological; Female; Follicle Stimulating Hormone; In Vitro Techniques; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Animal; Nitrobenzenes; Oocytes; Phosphorylation; Receptors, FSH; Receptors, Prostaglandin E; Signal Transduction; Sulfonamides; Swine

2011
Cox-2 inhibitors induce early c-Myc downregulation and lead to expression of differentiation markers in leukemia cells.
    Cell cycle (Georgetown, Tex.), 2011, Sep-01, Volume: 10, Issue:17

    Topics: Antigens, Differentiation; Apoptosis; Biomarkers; Celecoxib; Cell Differentiation; Cell Proliferation; Cell Survival; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Down-Regulation; Gene Expression Regulation, Leukemic; Humans; Interphase; Jurkat Cells; K562 Cells; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-myc; Pyrazoles; Sulfonamides; U937 Cells; Up-Regulation

2011
Endogenous prostaglandin E2 inhibits aberrant overgrowth of rheumatoid synovial tissue and the development of osteoclast activity through EP4 receptor.
    Arthritis and rheumatism, 2011, Volume: 63, Issue:9

    Topics: Arthritis, Rheumatoid; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Humans; Indomethacin; Nitrobenzenes; Osteoclasts; Receptors, Prostaglandin E, EP4 Subtype; Sulfonamides; Synovial Membrane

2011
Hypertonic stress induces VEGF production in human colon cancer cell line Caco-2: inhibitory role of autocrine PGE₂.
    PloS one, 2011, Volume: 6, Issue:9

    Topics: Caco-2 Cells; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Nitrobenzenes; Osmolar Concentration; Phospholipases A2, Cytosolic; Sulfonamides; Vascular Endothelial Growth Factor A

2011
Prophylactic and therapeutic benefits of COX-2 inhibitor on motility dysfunction in bowel obstruction: roles of PGE₂ and EP receptors.
    American journal of physiology. Gastrointestinal and liver physiology, 2012, Jan-15, Volume: 302, Issue:2

    Topics: Animals; Colon; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Gastrointestinal Motility; Intestinal Obstruction; Nitrobenzenes; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Sulfonamides

2012
Involvement of COX-2/PGE2 signalling in hypoxia-induced angiogenic response in endothelial cells.
    Journal of cellular and molecular medicine, 2012, Volume: 16, Issue:8

    Topics: Aquaporin 1; Cell Hypoxia; Cell Movement; Cell Proliferation; Cell Shape; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Immunohistochemistry; Neovascularization, Physiologic; Nitrobenzenes; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; RNA, Messenger; Signal Transduction; Sulfonamides; Time Factors; Transcription, Genetic; Vascular Endothelial Growth Factor A; Xanthones

2012
CD83-stimulated monocytes suppress T-cell immune responses through production of prostaglandin E2.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Nov-15, Volume: 108, Issue:46

    Topics: Antigens, CD; CD83 Antigen; Cell Proliferation; Cytokines; Dendritic Cells; Dinoprostone; Humans; Immune System; Immunoglobulins; Interferon-gamma; Interleukin-2; Membrane Glycoproteins; Monocytes; NF-kappa B; Nitrobenzenes; Recombinant Fusion Proteins; Sulfonamides; T-Lymphocytes; Transcription Factors

2011
Prostaglandin E2 contributes to the synthesis of brain-derived neurotrophic factor in primary sensory neuron in ganglion explant cultures and in a neuropathic pain model.
    Experimental neurology, 2012, Volume: 234, Issue:2

    Topics: Animals; Biphenyl Compounds; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Ganglia, Spinal; Hyperalgesia; Male; Neuralgia; Nitrobenzenes; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Sciatic Nerve; Sensory Receptor Cells; Signal Transduction; Sulfonamides; Up-Regulation

2012
IL-6 production stimulated by CD14(+) monocytes-paracrined IL-1β does not contribute to the immunosuppressive activity of human umbilical cord mesenchymal stem cells.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2012, Volume: 29, Issue:3-4

    Topics: CD4-Positive T-Lymphocytes; Cell Differentiation; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; Dinoprostone; Humans; Immunophenotyping; Immunosuppressive Agents; Interleukin-1beta; Interleukin-6; Leukocytes, Mononuclear; Lipopolysaccharide Receptors; Macrophage Activation; MAP Kinase Signaling System; Mesenchymal Stem Cells; Nitrobenzenes; Sulfonamides; Umbilical Cord

2012
Ellagic acid facilitates indomethacin-induced gastric ulcer healing via COX-2 up-regulation.
    Acta biochimica et biophysica Sinica, 2012, Volume: 44, Issue:7

    Topics: Animals; Blotting, Western; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cytokines; Dinoprostone; Dose-Response Relationship, Drug; Ellagic Acid; Enzyme-Linked Immunosorbent Assay; Gastric Mucosa; Indomethacin; Intercellular Signaling Peptides and Proteins; Male; Mice; Molecular Structure; Nitrobenzenes; Peroxidase; Pyrazoles; Stomach Ulcer; Sulfonamides; Time Factors; Up-Regulation; Wound Healing

2012
Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation.
    Cancer immunology, immunotherapy : CII, 2013, Volume: 62, Issue:2

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; ErbB Receptors; Humans; Indomethacin; Ki-67 Antigen; Lipopolysaccharide Receptors; Lipopolysaccharides; Lung Neoplasms; Membrane Proteins; Mice; Nitrobenzenes; Sulfonamides; Toll-Like Receptor 4

2013
Involvement of the P2X7 purinergic receptor and c-Jun N-terminal and extracellular signal-regulated kinases in cyclooxygenase-2 and prostaglandin E2 induction by LL-37.
    Journal of innate immunity, 2013, Volume: 5, Issue:1

    Topics: Antimicrobial Cationic Peptides; Cathelicidins; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Gingiva; Humans; Immunity, Mucosal; JNK Mitogen-Activated Protein Kinases; Nitrobenzenes; Periodontal Diseases; Receptors, Purinergic P2X7; Signal Transduction; Sulfonamides

2013
Melittin suppresses VEGF-A-induced tumor growth by blocking VEGFR-2 and the COX-2-mediated MAPK signaling pathway.
    Journal of natural products, 2012, Nov-26, Volume: 75, Issue:11

    Topics: Animals; Apoptosis; Colonic Neoplasms; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Human Umbilical Vein Endothelial Cells; Humans; Melitten; Mice; Mitogen-Activated Protein Kinase Kinases; Nitrobenzenes; Sulfonamides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

2012
The role of adipose tissue-associated macrophages and T lymphocytes in the pathogenesis of inflammatory bowel disease.
    Cytokine, 2013, Volume: 61, Issue:2

    Topics: Adipocytes; Adipose Tissue; Adult; Arginase; Case-Control Studies; Culture Media, Conditioned; Cytokines; Dinoprostone; Female; Humans; Inflammatory Bowel Diseases; Macrophages; Male; Middle Aged; Nitric Oxide Synthase Type II; Nitrobenzenes; Sulfonamides; T-Lymphocytes; Thioglycolates; Young Adult

2013
Effect of NS-398, a cyclooxygenase-2 selective inhibitor, on the cytotoxicity of cytotoxic T lymphocytes to ovarian carcinoma cells.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2013, Volume: 34, Issue:3

    Topics: Apoptosis; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cystadenocarcinoma, Serous; Dinoprostone; Female; Humans; Microscopy, Phase-Contrast; Nitrobenzenes; Ovarian Neoplasms; Sulfonamides; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured

2013
IL-1β/HMGB1 complexes promote The PGE2 biosynthesis pathway in synovial fibroblasts.
    Scandinavian journal of immunology, 2013, Volume: 77, Issue:5

    Topics: Arthritis; Biosynthetic Pathways; Blotting, Western; Cells, Cultured; Chemokines; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cytokines; Dinoprostone; Drug Synergism; Fibroblasts; HMGB1 Protein; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Interleukin-6; Interleukin-8; Intramolecular Oxidoreductases; Nitrobenzenes; Prostaglandin-E Synthases; Sulfonamides; Synovial Membrane

2013
Coculture with endothelial cells enhances osteogenic differentiation of periodontal ligament stem cells via cyclooxygenase-2/prostaglandin E2/vascular endothelial growth factor signaling under hypoxia.
    Journal of periodontology, 2013, Volume: 84, Issue:12

    Topics: Angiogenesis Inhibitors; Cell Culture Techniques; Cell Differentiation; Cell Hypoxia; Coculture Techniques; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Endothelial Cells; Flavonoids; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Nitrobenzenes; Osteogenesis; Periodontal Ligament; Prostaglandin Antagonists; Protein Kinase Inhibitors; Pyrroles; Signal Transduction; Stem Cells; Sulfonamides; Thiophenes; Triazoles; Vascular Endothelial Growth Factor A; Xanthones

2013
Regulation of nerve growth factor by anti-inflammatory drugs, a steroid, and a selective cyclooxygenase 2 inhibitor in human intervertebral disc cells stimulated with interleukin-1.
    Spine, 2013, Aug-01, Volume: 38, Issue:17

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Dexamethasone; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Gene Expression; Humans; Interleukin-1; Intervertebral Disc; Middle Aged; Nerve Growth Factor; Nitrobenzenes; Real-Time Polymerase Chain Reaction; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Sulfonamides

2013
Prostaglandin E(2) and insulin-like growth factor I interact to enhance proliferation of theca externa cells from chicken prehierarchical follicles.
    Prostaglandins & other lipid mediators, 2013, Volume: 106

    Topics: Animals; Cell Proliferation; Chickens; Cyclooxygenase 2; Dinoprostone; Drug Interactions; Female; Heterocyclic Compounds, 4 or More Rings; Insulin-Like Growth Factor I; Nitrobenzenes; RNA, Messenger; Sulfonamides; Tetrazoles; Theca Cells; Tyrphostins

2013
Coordinated induction of cyclooxygenase-2/prostaglandin E2 and hepatocyte growth factor by apoptotic cells prevents lung fibrosis.
    Journal of leukocyte biology, 2013, Volume: 94, Issue:5

    Topics: Animals; Apoptosis; Bleomycin; Cyclooxygenase 2; Dinoprostone; Hepatocyte Growth Factor; Indoles; Male; Mice; Mice, Inbred C57BL; Nitrobenzenes; Pulmonary Fibrosis; Signal Transduction; Sulfonamides; Sulfones; Xanthones

2013
COX-2 is involved in ET-1-induced hypertrophy of neonatal rat cardiomyocytes: role of NFATc3.
    Molecular and cellular endocrinology, 2014, Feb-15, Volume: 382, Issue:2

    Topics: Animals; Animals, Newborn; Calcineurin; Cardiomegaly; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclosporine; Dinoprostone; Endothelin-1; Gene Expression Regulation; Myocytes, Cardiac; Natriuretic Peptide, Brain; NFATC Transcription Factors; Nitrobenzenes; Primary Cell Culture; Promoter Regions, Genetic; Protein Binding; Pyrazoles; Rats; Rats, Sprague-Dawley; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Sulfonamides; Transcription, Genetic

2014
Effects of all-trans retinoic acid on signal pathway of cyclooxygenase-2 and Smad3 in transforming growth factor-β-stimulated glomerular mesangial cells.
    Experimental biology and medicine (Maywood, N.J.), 2014, Volume: 239, Issue:3

    Topics: Animals; Apoptosis; Cell Line; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Fibrosis; Glomerular Mesangium; Mesangial Cells; Nitrobenzenes; Protein Transport; Rats; RNA, Messenger; Signal Transduction; Smad3 Protein; Smad7 Protein; Staurosporine; Sulfonamides; Thromboxane A2; Transforming Growth Factor beta; Tretinoin

2014
Cyclic tensile force up-regulates BMP-2 expression through MAP kinase and COX-2/PGE2 signaling pathways in human periodontal ligament cells.
    Experimental cell research, 2014, Apr-15, Volume: 323, Issue:1

    Topics: Adult; Bite Force; Bone Morphogenetic Protein 2; Butadienes; Calcification, Physiologic; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Imidazoles; Male; Mastication; Molar, Third; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Stress, Physiological; Sulfonamides; Up-Regulation; Young Adult

2014
Liver myofibroblasts up-regulate monocyte CD163 expression via PGE2 during hepatitis B induced liver failure.
    Journal of translational medicine, 2014, Mar-06, Volume: 12

    Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cell Count; Cell Separation; Dinoprostone; Hepatitis B; Humans; Liver; Liver Failure; Monocytes; Myofibroblasts; Nitrobenzenes; Phenotype; Receptors, Cell Surface; Sulfonamides; Up-Regulation

2014
COX2 and PGE2 mediate EGF-induced E-cadherin-independent human ovarian cancer cell invasion.
    Endocrine-related cancer, 2014, Volume: 21, Issue:4

    Topics: Cadherins; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Down-Regulation; Epidermal Growth Factor; Female; Humans; Neoplasm Invasiveness; Nitrobenzenes; Ovarian Neoplasms; RNA, Small Interfering; Sulfonamides

2014
Helicobacter pylori promotes VEGF expression via the p38 MAPK‑mediated COX‑2‑PGE2 pathway in MKN45 cells.
    Molecular medicine reports, 2014, Volume: 10, Issue:4

    Topics: Cell Line, Tumor; Cyclooxygenase 2; Dinoprostone; HEK293 Cells; Helicobacter pylori; Humans; Imidazoles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; RNA Interference; RNA, Small Interfering; Sulfonamides; Up-Regulation; Vascular Endothelial Growth Factor A

2014
Interactions between neutrophils and non-small cell lung cancer cells: enhancement of tumor proliferation and inflammatory mediator synthesis.
    Cancer immunology, immunotherapy : CII, 2014, Volume: 63, Issue:12

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Communication; Cell Growth Processes; Cell Line, Tumor; Coculture Techniques; Cyclooxygenase 2; Dinoprostone; Humans; Leukocyte Elastase; Lipopolysaccharides; Lung Neoplasms; Neutrophils; Nitrobenzenes; Sulfonamides; Tumor Microenvironment

2014
Prostaglandin E2/leukotriene B4 balance induced by Lutzomyia longipalpis saliva favors Leishmania infantum infection.
    Parasites & vectors, 2014, Dec-20, Volume: 7

    Topics: Animals; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Female; Humans; Leishmania infantum; Leishmaniasis, Visceral; Leukocytes; Leukotriene B4; Macrophages; Male; Mice; Mice, Inbred C57BL; Nitrobenzenes; Psychodidae; Salivary Glands; Sulfonamides

2014
The Effect of Cadmium on COX-1 and COX-2 Gene, Protein Expression, and Enzymatic Activity in THP-1 Macrophages.
    Biological trace element research, 2015, Volume: 165, Issue:2

    Topics: Cadmium Chloride; Cell Line; Culture Media; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Enzymologic; Gene Silencing; Humans; Macrophages; Monocytes; Nitrobenzenes; RNA, Messenger; Sulfonamides; Thromboxane A2; Thromboxane B2

2015
Docosahexaenoic acid differentially affects TNFα and IL-6 expression in LPS-stimulated RAW 264.7 murine macrophages.
    Prostaglandins, leukotrienes, and essential fatty acids, 2015, Volume: 97

    Topics: Animals; Blotting, Western; Cell Line; Dinoprostone; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Gene Expression; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Nitriles; Nitrobenzenes; Peptides; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Sulfones; Tumor Necrosis Factor-alpha

2015
Inhibition of cyclooxygenase-2 causes a decrease in coronary flow in diabetic mice. The possible role of PGE2 and dysfunctional vasodilation mediated by prostacyclin receptor.
    Journal of physiology and biochemistry, 2015, Volume: 71, Issue:3

    Topics: Animals; Coronary Vessels; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diabetes Mellitus, Type 2; Dinoprostone; Epoprostenol; Male; Mice, Obese; Nitrobenzenes; Receptors, Epoprostenol; Receptors, Prostaglandin; Regional Blood Flow; Sulfonamides; Vasodilation

2015
Role of cyclooxygenase-2 in Trypanosoma cruzi survival in the early stages of parasite host-cell interaction.
    Memorias do Instituto Oswaldo Cruz, 2015, Volume: 110, Issue:2

    Topics: Active Transport, Cell Nucleus; Animals; CELF Proteins; Cell Line; Cell Nucleus; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Fluorescent Dyes; Host-Parasite Interactions; Immunoprecipitation; In Situ Hybridization; Interleukin-1beta; Myocytes, Cardiac; Nitrobenzenes; Rats; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Protozoan; Sulfonamides; Time Factors; Trypanosoma cruzi

2015
[Production and mechanism of CCL5 by macrophages in U14 cervical cancer-bearing mice during infection].
    Zhonghua fu chan ke za zhi, 2015, Volume: 50, Issue:5

    Topics: Animals; Chemokine CCL5; Culture Media, Conditioned; Cyclic AMP; Cyclooxygenase 2; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; Nitrobenzenes; Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sulfonamides; Uterine Cervical Neoplasms

2015
Anti-Inflammation of N-Benzyl-4-Bromobenzamide in Lipopolysaccharide-Induced Human Gingival Fibroblasts.
    Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2016, Volume: 25, Issue:2

    Topics: Analysis of Variance; Antioxidants; Cell Survival; Dinoprostone; Enzyme Activation; Fibroblasts; Humans; Interleukin-6; Lipopolysaccharides; Nitrobenzenes; Porphyromonas gingivalis; Sulfonamides

2016
Enhanced cyclooxygenase-2 activity leads to intestinal dysmotility following hemorrhagic shock.
    Acta cirurgica brasileira, 2015, Volume: 30, Issue:12

    Topics: Acetylcholine; Animals; Cyclooxygenase 2; Dinoprostone; Duodenum; Gastrointestinal Motility; Male; Models, Animal; Muscle Contraction; Nitrobenzenes; Random Allocation; Rats, Wistar; Shock, Hemorrhagic; Sulfonamides

2015
Madecassoside suppresses proliferation and invasiveness of HGF-induced human hepatocellular carcinoma cells via PKC-cMET-ERK1/2-COX-2-PGE2 pathway.
    International immunopharmacology, 2016, Volume: 33

    Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Centella; Cyclooxygenase 2; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Hep G2 Cells; Hepatocyte Growth Factor; Humans; Liver Neoplasms; Neoplasm Invasiveness; Nitrobenzenes; Protein Kinase C; Proto-Oncogene Proteins c-met; RNA, Small Interfering; Signal Transduction; Sulfonamides; Triterpenes

2016
Prostaglandin I₂ Attenuates Prostaglandin E₂-Stimulated Expression of Interferon γ in a β-Amyloid Protein- and NF-κB-Dependent Mechanism.
    Scientific reports, 2016, Feb-12, Volume: 6

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Brain; Cell Nucleus; Dinoprostone; Disease Progression; Down-Regulation; Epoprostenol; Female; Interferon-gamma; Mice, Inbred C57BL; Mice, Transgenic; Models, Biological; NF-kappa B; Nitrobenzenes; Presenilin-1; Protein Aggregation, Pathological; Signal Transduction; Sulfonamides; Up-Regulation

2016
Macrophages programmed by apoptotic cells inhibit epithelial-mesenchymal transition in lung alveolar epithelial cells via PGE2, PGD2, and HGF.
    Scientific reports, 2016, Feb-15, Volume: 6

    Topics: Alveolar Epithelial Cells; Amides; Animals; Apoptosis; Culture Media, Conditioned; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Epithelial-Mesenchymal Transition; Gene Expression Regulation; Hepatocyte Growth Factor; Macrophages; Mice; Nitrobenzenes; Prostaglandin D2; Pyridines; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Sulfonamides

2016
Novel effects of the cyclooxygenase-2-selective inhibitor NS-398 on IL-1β-induced cyclooxygenase-2 and IL-8 expression in human ovarian granulosa cells.
    Innate immunity, 2016, Volume: 22, Issue:6

    Topics: Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Female; Gene Expression Regulation; Granulosa Cells; Humans; Inflammation; Interleukin-1beta; Interleukin-8; NF-kappa B; Nitrobenzenes; Ovulation; Signal Transduction; Sulfonamides

2016
Indoxyl Sulfate Induces Mesangial Cell Proliferation via the Induction of COX-2.
    Mediators of inflammation, 2016, Volume: 2016

    Topics: Animals; Blotting, Western; Cell Cycle; Cell Line; Cell Proliferation; Cyclin A2; Cyclin D1; Cyclooxygenase 2; Dinoprostone; Immunoassay; Indican; Mesangial Cells; Mice; Nitrobenzenes; Real-Time Polymerase Chain Reaction; Sulfonamides

2016
Crotalus helleri venom preconditioning reduces postoperative cerebral edema and improves neurological outcomes after surgical brain injury.
    Neurobiology of disease, 2017, Volume: 107

    Topics: Animals; Body Water; Brain; Brain Edema; Crotalus; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Disease Models, Animal; Epidermis; Frontal Lobe; Inflammation; Intraoperative Complications; Male; Neuroprotective Agents; Neurosurgical Procedures; Nitrobenzenes; Postoperative Complications; Rats, Sprague-Dawley; Snake Venoms; Sulfonamides

2017
Cyclooxygenase-2 facilitates dengue virus replication and serves as a potential target for developing antiviral agents.
    Scientific reports, 2017, 03-20, Volume: 7

    Topics: Animals; Animals, Suckling; Antiviral Agents; Biocatalysis; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Cyclooxygenase 2; Dengue; Dengue Virus; Dinoprostone; Humans; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; Models, Biological; Molecular Targeted Therapy; NF-kappa B; Nitrobenzenes; Promoter Regions, Genetic; RNA, Small Interfering; Sulfonamides; Virus Replication

2017
Adipose-derived mesenchymal stem cells modulate CD14
    Stem cell research & therapy, 2017, 04-26, Volume: 8, Issue:1

    Topics: Adipose Tissue; Aged; Animals; Cells, Cultured; Coculture Techniques; Cohort Studies; Cyclooxygenase 2 Inhibitors; Cytokines; Dinoprostone; Female; Humans; Intensive Care Units; Lipopolysaccharide Receptors; Lipopolysaccharides; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Middle Aged; Monocytes; Nitrobenzenes; Phenotype; Prospective Studies; Receptors, IgG; Sepsis; Severity of Illness Index; Sulfonamides

2017
Activation of COX-2/mPGES-1/PGE2 Cascade via NLRP3 Inflammasome Contributes to Albumin-Induced Proximal Tubule Cell Injury.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 42, Issue:2

    Topics: Albumins; Animals; Apoptosis; Cyclooxygenase 2; Dinoprostone; Gene Expression Regulation; Humans; Inflammasomes; Kidney Tubules, Proximal; Mice; Nitrobenzenes; NLR Family, Pyrin Domain-Containing 3 Protein; Prostaglandin-E Synthases; Proteinuria; RNA, Messenger; RNA, Small Interfering; Sulfonamides

2017
Nicotine increases colon cancer cell migration and invasion through epithelial to mesenchymal transition (EMT): COX-2 involvement.
    Journal of cellular physiology, 2018, Volume: 233, Issue:6

    Topics: Antigens, CD; Antineoplastic Agents; beta Catenin; Caco-2 Cells; Cadherins; Carcinogens; Cell Movement; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Epithelial-Mesenchymal Transition; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Nicotine; Nitrobenzenes; Signal Transduction; Sulfonamides

2018
Temporal Regulation of the Bacterial Metabolite Deoxycholate during Colonic Repair Is Critical for Crypt Regeneration.
    Cell host & microbe, 2018, 09-12, Volume: 24, Issue:3

    Topics: Animals; Bacteria; Biopsy; Colon; Cyclooxygenase 2; Deoxycholic Acid; Dinoprostone; Gastrointestinal Microbiome; Hydroxyprostaglandin Dehydrogenases; Intestinal Mucosa; Mice; Mice, Knockout; Nitrobenzenes; Primary Cell Culture; Sulfonamides; Vancomycin; Wound Healing

2018
Interleukin-1β and prostaglandin-synthesizing enzymes as modulators of human omental and subcutaneous adipose tissue function.
    Prostaglandins, leukotrienes, and essential fatty acids, 2019, Volume: 141

    Topics: Adipocytes; Adipogenesis; Aldehyde Reductase; Cell Differentiation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytokines; Dinoprost; Dinoprostone; Female; Humans; Inflammation; Interleukin-1beta; Intra-Abdominal Fat; Male; Middle Aged; Nitrobenzenes; Obesity; Omentum; Phthalazines; PPAR gamma; Subcutaneous Fat, Abdominal; Sulfonamides

2019
Effect of mechanical strain-induced PGE
    Journal of oral science, 2019, Mar-28, Volume: 61, Issue:1

    Topics: Animals; Bone and Bones; Bone Morphogenetic Protein 2; Core Binding Factor Alpha 1 Subunit; Cyclooxygenase 2 Inhibitors; Dinoprostone; Homeodomain Proteins; Nitrobenzenes; Rats; Skull; Stem Cells; Stress, Mechanical; Sulfonamides

2019
Effects of Prostaglandins E2 and F2α on the in vitro maturation of bovine oocytes.
    Domestic animal endocrinology, 2020, Volume: 72

    Topics: Animals; Cattle; Dinoprost; Dinoprostone; Embryo Culture Techniques; Gene Expression Regulation, Developmental; In Vitro Oocyte Maturation Techniques; Nitrobenzenes; Oocytes; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sulfonamides

2020
Inhibition of COX-2 ameliorates murine liver schistosomiasis japonica through splenic cellular immunoregulation.
    Parasites & vectors, 2022, Apr-23, Volume: 15, Issue:1

    Topics: Animals; Cyclooxygenase 2; Dinoprostone; Immunity; Inflammation; Liver; Mice; Mice, Inbred C57BL; Nitrobenzenes; Schistosoma japonicum; Schistosomiasis; Schistosomiasis japonica; Spleen; Sulfonamides

2022
Herbal melanin modulates PGE2 and IL-6 gastroprotective markers through COX-2 and TLR4 signaling in the gastric cancer cell line AGS.
    BMC complementary medicine and therapies, 2023, Sep-01, Volume: 23, Issue:1

    Topics: Animals; Cyclooxygenase 2; Dinoprostone; Humans; Interleukin-6; Melanins; Mucin-4; Rats; Stomach Neoplasms; Toll-Like Receptor 4

2023
Prostaglandin E2 contributes to
    Emerging microbes & infections, 2023, Volume: 12, Issue:2

    Topics: Cyclooxygenase 2; Dinoprostone; Humans; Leishmania braziliensis; Leishmaniasis, Cutaneous

2023