n-(2-chloroethyl)-4-piperidinyl diphenylacetate has been researched along with piperidines in 26 studies
| Studies (n-(2-chloroethyl)-4-piperidinyl diphenylacetate) | Trials (n-(2-chloroethyl)-4-piperidinyl diphenylacetate) | Recent Studies (post-2010) (n-(2-chloroethyl)-4-piperidinyl diphenylacetate) | Studies (piperidines) | Trials (piperidines) | Recent Studies (post-2010) (piperidines) |
|---|---|---|---|---|---|
| 27 | 0 | 3 | 40,235 | 5,221 | 14,545 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (69.23) | 18.2507 |
| 2000's | 6 (23.08) | 29.6817 |
| 2010's | 2 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barlow, RB; McMillen, LS; Veale, MA | 1 |
| Ehlert, FJ; Thomas, EA | 1 |
| Ehlert, FJ; Griffin, MT; Hsu, HH; Hunter, AL; Luong, T; Thomas, EA | 1 |
| Barlow, RB; Christophe, J; Renzetti, AR; Tastenoy, M; Waelbroeck, M | 1 |
| Barlow, RB; Shepherd, MK; Veale, MA | 1 |
| Eglen, RM; Reddy, H; Watson, N | 1 |
| Hendriks, MG; Pfaffendorf, M; van Zwieten, PA | 1 |
| Ehlert, FJ; Griffin, MT; Thomas, EA | 1 |
| Baker, SA; Ehlert, FJ; Thomas, EA | 1 |
| Eglen, RM; Harris, GC | 1 |
| Ehlert, FJ; Griffin, MT; Oliff, HS | 1 |
| Ehlert, FJ | 1 |
| Alpini, G; Alvaro, D; Bassotti, C; Benedetti, A; Fraioli, F; Francia, C; Glaser, SS; Jezequel, AM; Le Sage, G; Marucci, L; Romeo, R | 1 |
| Ehlert, FJ; Griffin, MT | 1 |
| Ehlert, FJ; Ostrom, RS | 2 |
| Mitchelson, F; Shen, A | 1 |
| Ehlert, FJ; Sawyer, GW | 1 |
| Ehlert, FJ; Lambrecht, G; Sawyer, GW | 1 |
| Ansari, KZ; Ehlert, FJ; Shehnaz, D | 1 |
| Abe, DM; Ehlert, FJ; Griffin, MT; Manabe, T; Matsui, M; Taketo, MM; Vo, TH | 1 |
| Bodenstein, J; Brink, CB; Venter, DP | 1 |
| Alreja, M; Morozova, E; Wu, M; Xu, C | 1 |
| Ehlert, FJ; Griffin, MT; Matsui, M; Ostrom, RS | 1 |
| Antony, S; George, N; Kuruvilla, KP; Paulose, CS; Peeyush Kumar, T; Soman, S | 1 |
| Araki, I; Ehlert, FJ; Masuyama, K; Nasrin, S; Otsuka, A; Ozono, S; Seki, M; Takeda, M; Yamada, S; Yoshida, A | 1 |
2 review(s) available for n-(2-chloroethyl)-4-piperidinyl diphenylacetate and piperidines
| Article | Year |
|---|---|
The interaction of 4-DAMP mustard with subtypes of the muscarinic receptor.
Topics: Alkylation; Animals; Diphenylacetic Acids; Kinetics; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Piperidines; Receptors, Muscarinic | 1996 |
The use of irreversible ligands to inactivate receptor subtypes: 4-DAMP mustard and muscarinic receptors in smooth muscle.
Topics: Animals; Diphenylacetic Acids; Humans; Kinetics; Ligands; Muscarinic Antagonists; Muscle, Smooth; Piperidines; Receptors, Muscarinic | 1998 |
24 other study(ies) available for n-(2-chloroethyl)-4-piperidinyl diphenylacetate and piperidines
| Article | Year |
|---|---|
The use of 4-diphenylacetoxy-N-(2-chloroethyl)-piperidine (4-DAMP mustard) for estimating the apparent affinities of some agonists acting at muscarinic receptors in guinea-pig ileum.
Topics: Animals; Diphenylacetic Acids; Guinea Pigs; Ileum; In Vitro Techniques; Indomethacin; Male; Muscarinic Agonists; Piperidines; Receptors, Muscarinic | 1991 |
Irreversible effects of 4-DAMP mustard on muscarinic receptors in vivo.
Topics: Alkylating Agents; Animals; Diphenylacetic Acids; Male; N-Methylscopolamine; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives | 1992 |
Conversion of N-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-DAMP mustard) to an aziridinium ion and its interaction with muscarinic receptors in various tissues.
Topics: Alkylation; Animals; Aziridines; Binding Sites; Brain; Diphenylacetic Acids; Drug Interactions; Hydrogen-Ion Concentration; Ileum; In Vitro Techniques; Kinetics; Male; Myocardium; N-Methylscopolamine; Oxotremorine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Submandibular Gland; Temperature | 1992 |
Inactivation of brain cortex muscarinic receptors by 4-diphenylacetoxy-1-(2-chloroethyl) piperidine mustard.
Topics: Animals; Carbachol; Cerebral Cortex; Diphenylacetic Acids; Muscarinic Antagonists; Myocardium; Piperidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1992 |
Some differential effects of 4-diphenylacetoxy-N-(2-chloroethyl)-piperidine hydrochloride on guinea-pig atria and ileum.
Topics: Animals; Aziridines; Cyclization; Diphenylacetic Acids; Guinea Pigs; Heart; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Parasympatholytics; Piperidines; Temperature | 1990 |
Role of muscarinic M2 and M3 receptors in guinea-pig trachea: effects of receptor alkylation.
Topics: Alkylation; Animals; Diamines; Dioxolanes; Diphenylacetic Acids; Drug Interactions; Guinea Pigs; Histamine; Isoproterenol; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Oxotremorine; Piperidines; Receptors, Muscarinic; Stimulation, Chemical; Trachea | 1995 |
The effect of muscarinic receptor alkylation on endothelium-dependent vasodilation in SHR.
Topics: Alkylating Agents; Alkylation; Animals; Blood Pressure; Diphenylacetic Acids; Endothelium, Vascular; Male; Methacholine Compounds; Piperidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Muscarinic; Vascular Resistance; Vasodilation | 1993 |
Kinetics of activation and in vivo muscarinic receptor binding of N-(2-bromoethyl)-4-piperidinyl diphenylacetate: an analog of 4-DAMP mustard.
Topics: Animals; Aziridines; Diphenylacetic Acids; Kinetics; Male; Myocardium; Piperidines; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Submandibular Gland | 1993 |
Functional role for the M2 muscarinic receptor in smooth muscle of guinea pig ileum.
Topics: Animals; Cyclic AMP; Diphenylacetic Acids; Guinea Pigs; Hydrolysis; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Phosphatidylinositols; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Second Messenger Systems | 1993 |
Selective inactivation of muscarinic M2 and M3 receptors in guinea-pig ileum and atria in vitro.
Topics: Alkylating Agents; Animals; Atropine; Diamines; Dioxolanes; Diphenylacetic Acids; Guinea Pigs; Heart; Heart Atria; Ileum; In Vitro Techniques; Isometric Contraction; Male; Muscarinic Antagonists; Muscle, Smooth; Parasympatholytics; Phenoxybenzamine; Pilocarpine; Piperidines; Receptors, Muscarinic | 1993 |
The quaternary transformation products of N-(3-chloropropyl)-4-piperidinyl diphenylacetate and N-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-DAMP mustard) have differential affinity for subtypes of the muscarinic receptor.
Topics: Animals; CHO Cells; Cricetinae; Diphenylacetic Acids; Male; Muscarinic Antagonists; N-Methylscopolamine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Scopolamine Derivatives | 1996 |
Role and mechanisms of action of acetylcholine in the regulation of rat cholangiocyte secretory functions.
Topics: Acetylcholine; Animals; Antiporters; Bicarbonates; Bile Ducts, Intrahepatic; Calcineurin Inhibitors; Chelating Agents; Chloride-Bicarbonate Antiporters; Chlorides; Cyclic AMP; Cyclosporine; Diphenylacetic Acids; Egtazic Acid; Fluorescent Antibody Technique, Indirect; Hydrogen-Ion Concentration; In Vitro Techniques; Microscopy, Immunoelectron; Muscarinic Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Secretin; Staurosporine; Tacrolimus | 1997 |
M2 muscarinic receptors inhibit forskolin- but not isoproterenol-mediated relaxation in bovine tracheal smooth muscle.
Topics: Animals; Cattle; Colforsin; Cyclic AMP; Diphenylacetic Acids; Histamine; In Vitro Techniques; Isoproterenol; Muscle Relaxation; Muscle, Smooth; Oxotremorine; Piperidines; Receptor, Muscarinic M2; Receptors, Muscarinic; Trachea | 1998 |
Muscarinic M2 receptor-mediated contraction in the guinea pig Taenia caeci: possible involvement of protein kinase C.
Topics: Animals; Cecum; Colforsin; Diphenylacetic Acids; Female; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Kinetics; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Parasympathomimetics; Piperidines; Pirenzepine; Protein Kinase C; Receptor, Muscarinic M2; Receptors, Muscarinic; Second Messenger Systems | 1998 |
Comparison of functional antagonism between isoproterenol and M2 muscarinic receptors in guinea pig ileum and trachea.
Topics: Animals; Colforsin; Diphenylacetic Acids; Guinea Pigs; Histamine; Ileum; Isoproterenol; Muscle Relaxation; Oxotremorine; Pertussis Toxin; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptors, Muscarinic; Trachea; Virulence Factors, Bordetella | 1999 |
Muscarinic M3 receptor inactivation reveals a pertussis toxin-sensitive contractile response in the guinea pig colon: evidence for M2/M3 receptor interactions.
Topics: Animals; Colon; Diphenylacetic Acids; Guinea Pigs; Hydrolysis; In Vitro Techniques; Male; Models, Biological; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Oxotremorine; Pertussis Toxin; Phosphatidylinositols; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Virulence Factors, Bordetella | 1999 |
Functional role of muscarinic M(2) receptors in alpha,beta-methylene ATP induced, neurogenic contractions in guinea-pig ileum.
Topics: Adenosine Triphosphate; Animals; Diphenylacetic Acids; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; N-Methylscopolamine; Pertussis Toxin; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptors, Muscarinic; Tetrodotoxin; Virulence Factors, Bordetella | 2000 |
Acetylcholine-induced desensitization of the contractile response to histamine in Guinea pig ileum is prevented by either pertussis toxin treatment or by selective inactivation of muscarinic M(3) receptors.
Topics: Acetylcholine; Animals; Diphenylacetic Acids; GTP-Binding Protein alpha Subunits, Gi-Go; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Inositol Phosphates; Isoenzymes; Male; Muscarinic Antagonists; Muscle Contraction; Pertussis Toxin; Phospholipase C beta; Piperidines; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Type C Phospholipases; Virulence Factors, Bordetella | 2001 |
The M2 muscarinic receptor mediates contraction through indirect mechanisms in mouse urinary bladder.
Topics: Adrenergic beta-Agonists; Animals; Binding, Competitive; Colforsin; Dinoprost; Diphenylacetic Acids; In Vitro Techniques; Isoproterenol; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Agonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Oxotremorine; Piperidines; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Urinary Bladder | 2005 |
Phenoxybenzamine and benextramine, but not 4-diphenylacetoxy-N-[2-chloroethyl]piperidine hydrochloride, display irreversible noncompetitive antagonism at G protein-coupled receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cell Line; Cell Line, Tumor; CHO Cells; Cricetinae; Cyclic AMP; Cystamine; Diphenylacetic Acids; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Protein alpha Subunits, Gs; Humans; Inositol Phosphates; Ligands; Phenoxybenzamine; Piperidines; Receptor, Serotonin, 5-HT2A; Receptors, G-Protein-Coupled; Receptors, Muscarinic; Second Messenger Systems; Serotonin Receptor Agonists; Signal Transduction | 2005 |
Muscarine activates the sodium-calcium exchanger via M receptors in basal forebrain neurons.
Topics: Animals; Basal Ganglia; Biotransformation; Diagonal Band of Broca; Diphenylacetic Acids; Electrophysiology; In Vitro Techniques; Ion Channels; Ions; Lithium Chloride; Male; Muscarine; Muscarinic Agonists; Patch-Clamp Techniques; Piperidines; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M3; Sodium-Calcium Exchanger; Thiourea | 2006 |
The guinea pig ileum lacks the direct, high-potency, M(2)-muscarinic, contractile mechanism characteristic of the mouse ileum.
Topics: Animals; Diphenylacetic Acids; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Oxotremorine; Piperidines; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Species Specificity | 2009 |
Role of curcumin in the prevention of cholinergic mediated cortical dysfunctions in streptozotocin-induced diabetic rats.
Topics: Acetylcholinesterase; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antibodies; Atropine; Cerebral Cortex; Choline O-Acetyltransferase; Curcumin; Diabetes Mellitus, Experimental; Diphenylacetic Acids; Gene Expression Regulation; Glucose Transporter Type 3; Male; Maze Learning; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptor, Insulin; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Receptors, Cholinergic; Receptors, Nicotinic; Superoxide Dismutase | 2011 |
Characterization of muscarinic receptors in the human bladder mucosa: direct quantification of subtypes using 4-DAMP mustard.
Topics: Aged; Aged, 80 and over; Binding, Competitive; Diphenylacetic Acids; Humans; In Vitro Techniques; Male; Middle Aged; Mucous Membrane; Muscarinic Antagonists; Muscle, Smooth; N-Methylscopolamine; Parotid Gland; Piperidines; Radioligand Assay; Receptors, Muscarinic; Urinary Bladder | 2011 |