Compounds > n-(2-chloroethyl)-4-piperidinyl diphenylacetate
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n-(2-chloroethyl)-4-piperidinyl diphenylacetate and oxotremorine

n-(2-chloroethyl)-4-piperidinyl diphenylacetate has been researched along with oxotremorine in 7 studies

Compound Research Comparison

Studies
(n-(2-chloroethyl)-4-piperidinyl diphenylacetate)		Trials
(n-(2-chloroethyl)-4-piperidinyl diphenylacetate)		Recent Studies (post-2010)
(n-(2-chloroethyl)-4-piperidinyl diphenylacetate)		Studies
(oxotremorine)		Trials
(oxotremorine)		Recent Studies (post-2010) (oxotremorine)
27031,930699

Protein Interaction Comparison

ProteinTaxonomyn-(2-chloroethyl)-4-piperidinyl diphenylacetate (IC50)oxotremorine (IC50)
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.4
Muscarinic acetylcholine receptor M4Homo sapiens (human)5
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)2.321
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)2.7261
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)2.7261
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)2.7261
Muscarinic acetylcholine receptor M5Homo sapiens (human)8
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)2.7261
Muscarinic acetylcholine receptor M1Homo sapiens (human)4.5012

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (71.43)18.2507
2000's2 (28.57)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ehlert, FJ; Griffin, MT; Hsu, HH; Hunter, AL; Luong, T; Thomas, EA1
Eglen, RM; Reddy, H; Watson, N1
Ehlert, FJ; Ostrom, RS2
Ehlert, FJ; Sawyer, GW1
Abe, DM; Ehlert, FJ; Griffin, MT; Manabe, T; Matsui, M; Taketo, MM; Vo, TH1
Ehlert, FJ; Griffin, MT; Matsui, M; Ostrom, RS1

Other Studies

7 other study(ies) available for n-(2-chloroethyl)-4-piperidinyl diphenylacetate and oxotremorine

ArticleYear
Conversion of N-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-DAMP mustard) to an aziridinium ion and its interaction with muscarinic receptors in various tissues.
    Molecular pharmacology, 1992, Volume: 41, Issue:4

    Topics: Alkylation; Animals; Aziridines; Binding Sites; Brain; Diphenylacetic Acids; Drug Interactions; Hydrogen-Ion Concentration; Ileum; In Vitro Techniques; Kinetics; Male; Myocardium; N-Methylscopolamine; Oxotremorine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Submandibular Gland; Temperature

1992
Role of muscarinic M2 and M3 receptors in guinea-pig trachea: effects of receptor alkylation.
    European journal of pharmacology, 1995, May-24, Volume: 278, Issue:3

    Topics: Alkylation; Animals; Diamines; Dioxolanes; Diphenylacetic Acids; Drug Interactions; Guinea Pigs; Histamine; Isoproterenol; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Oxotremorine; Piperidines; Receptors, Muscarinic; Stimulation, Chemical; Trachea

1995
M2 muscarinic receptors inhibit forskolin- but not isoproterenol-mediated relaxation in bovine tracheal smooth muscle.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:1

    Topics: Animals; Cattle; Colforsin; Cyclic AMP; Diphenylacetic Acids; Histamine; In Vitro Techniques; Isoproterenol; Muscle Relaxation; Muscle, Smooth; Oxotremorine; Piperidines; Receptor, Muscarinic M2; Receptors, Muscarinic; Trachea

1998
Comparison of functional antagonism between isoproterenol and M2 muscarinic receptors in guinea pig ileum and trachea.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:3

    Topics: Animals; Colforsin; Diphenylacetic Acids; Guinea Pigs; Histamine; Ileum; Isoproterenol; Muscle Relaxation; Oxotremorine; Pertussis Toxin; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptors, Muscarinic; Trachea; Virulence Factors, Bordetella

1999
Muscarinic M3 receptor inactivation reveals a pertussis toxin-sensitive contractile response in the guinea pig colon: evidence for M2/M3 receptor interactions.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:1

    Topics: Animals; Colon; Diphenylacetic Acids; Guinea Pigs; Hydrolysis; In Vitro Techniques; Male; Models, Biological; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Oxotremorine; Pertussis Toxin; Phosphatidylinositols; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Virulence Factors, Bordetella

1999
The M2 muscarinic receptor mediates contraction through indirect mechanisms in mouse urinary bladder.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:1

    Topics: Adrenergic beta-Agonists; Animals; Binding, Competitive; Colforsin; Dinoprost; Diphenylacetic Acids; In Vitro Techniques; Isoproterenol; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Agonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Oxotremorine; Piperidines; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Urinary Bladder

2005
The guinea pig ileum lacks the direct, high-potency, M(2)-muscarinic, contractile mechanism characteristic of the mouse ileum.
    Naunyn-Schmiedeberg's archives of pharmacology, 2009, Volume: 380, Issue:4

    Topics: Animals; Diphenylacetic Acids; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Oxotremorine; Piperidines; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Species Specificity

2009