n-(2-aminoethyl)-4-chlorobenzamide-hydrochloride has been researched along with milacemide* in 1 studies
1 other study(ies) available for n-(2-aminoethyl)-4-chlorobenzamide-hydrochloride and milacemide
Article | Year |
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Milacemide, a glycine prodrug, enhances performance of learning tasks in normal and amnestic rodents.
The N-methyl-D-aspartate receptor complex appears to play an important role in processes of learning and memory. The presence of a glycine modulatory site at this complex has recently been established and suggests that glycinergic neurotransmission may influence these cognitive functions. Increasing glycine concentrations in the brain by administration of a glycine prodrug, milacemide, is shown here to enhance performance of a shock-motivated passive avoidance task in rats, and to reverse drug-induced amnesia in a spontaneous alternation paradigm in mice. Prevention of the metabolism of milacemide to glycine by pretreatment with MAO-B inhibitors not only prevents the memory-enhancing effects of the drug, but appears to have a deleterious effect on memory formation suggesting an action of the prodrug itself on the brain. These studies indicate a role of glycinergic neurotransmission in memory processes, and support the therapeutic potential of glycinergic drugs in memory impairment. Topics: Acetamides; Amnesia; Animals; Avoidance Learning; Benzamides; Exploratory Behavior; Glycine; Male; Mice; Monoamine Oxidase Inhibitors; Prodrugs; Rats; Selegiline | 1989 |