n-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-n,n',n',n'',n''-pentaacetic acid has been researched along with yttrium radioisotopes in 16 studies
| Studies (n-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-n,n',n',n'',n''-pentaacetic acid) | Trials (n-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-n,n',n',n'',n''-pentaacetic acid) | Recent Studies (post-2010) (n-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-n,n',n',n'',n''-pentaacetic acid) | Studies (yttrium radioisotopes) | Trials (yttrium radioisotopes) | Recent Studies (post-2010) (yttrium radioisotopes) |
|---|---|---|---|---|---|
| 40 | 0 | 7 | 3,407 | 339 | 1,533 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 6 (37.50) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brechbiel, MW; Camera, L; Gansow, OA; Garmestani, K; Kinuya, S; McMurry, TJ; Pai, LH; Paik, CH; Pastan, I; Wu, C | 1 |
| Brechbiel, MW; Carrasquillo, JA; Drumm, D; Gansow, OA; Kobayashi, H; Paik, CH; Pastan, I; Sun, BF; Wu, C; Yoo, TM | 1 |
| Brechbiel, M; Kennel, SJ; Mirzadeh, S; Stabin, M; Yoriyaz, H | 1 |
| Brechbiel, MW; Colcher, D; Gansow, OA; Milenic, DE; Mirzadeh, S; Pippin, CG; Roselli, M; Schlom, J | 1 |
| Blend, MJ; Brechbiel, MW; Stastny, JJ; Swanson, SM | 1 |
| Adams, GP; Brechbiel, MW; Dadachova, E; Horak, EM; Klein-Szanto, AJ; Marks, JD; Shaller, CC; Simmons, HH; Tesfaye, A; Weiner, LM | 1 |
| Alicke, B; Biroc, S; Bringmann, P; Cobb, RR; Dinter, H; Halks-Miller, M; Harkins, R; Hudson, D; Klocker, H; Kretschmer, PJ; Larsen, B; Lewis, JS; Lin, R; Newton, A; Parkes, D; Parry, G; Parry, R; Roth, G; Schneider, D; Toy, P; Xuan, JA; Zhu, Y | 1 |
| Biddlecombe, GB; Boswell, CA; Brechbiel, MW; Clifford, T; Lewis, JS | 1 |
| Baidoo, K; Boswell, CA; Brechbiel, MW; Choyke, PL; Gunn, AJ; Milenic, DE; Xu, H | 1 |
| Alicke, B; Heitner, T; Lewis, JS; Light, DR; McLean, K; Parry, G; Parry, R; Satozawa, N; Schneider, DW; Yoo, J | 1 |
| Baidoo, KE; Brechbiel, MW; Garmestani, K; Milenic, DE; Nayak, TK; Regino, CA; Szajek, LP; Wong, KJ | 1 |
| Baidoo, KE; Brechbiel, MW; Garmestani, K; Milenic, DE; Nayak, TK | 2 |
| Baumann, M; Cordes, N; Dittfeld, C; Heldt, JM; Ingargiola, M; Kotzerke, J; Kunz-Schughart, LA; Runge, R; Steinbach, J; Zenker, M | 1 |
| Baumann, M; Bergmann, R; Brüchner, K; Koi, L; Krause, M; Pietzsch, HJ; Pietzsch, J; Steinbach, J; Zips, D | 1 |
| Adam, MJ; Carlin, SD; Carnazza, KE; Edwards, KJ; Lewis, JS; Orvig, C; Price, EW; Zeglis, BM | 1 |
16 other study(ies) available for n-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-n,n',n',n'',n''-pentaacetic acid and yttrium radioisotopes
| Article | Year |
|---|---|
Evaluation of the serum stability and in vivo biodistribution of CHX-DTPA and other ligands for yttrium labeling of monoclonal antibodies.
Topics: Animals; Bone and Bones; Chelating Agents; Drug Stability; Female; Heterocyclic Compounds; Indium Radioisotopes; Isothiocyanates; Ligands; Mice; Mice, Nude; Pentetic Acid; Radioimmunotherapy; Tissue Distribution; Yttrium Radioisotopes | 1994 |
Evaluation of the in vivo biodistribution of yttrium-labeled isomers of CHX-DTPA-conjugated monoclonal antibodies.
Topics: Animals; Bone and Bones; Chelating Agents; Female; Isothiocyanates; Mice; Mice, Nude; Pentetic Acid; Radioimmunotherapy; Stereoisomerism; Time Factors; Tissue Distribution; Yttrium Radioisotopes | 1998 |
Treatment of lung tumor colonies with 90Y targeted to blood vessels: comparison with the alpha-particle emitter 213Bi.
Topics: Animals; Antibodies, Monoclonal; Bismuth; Dose-Response Relationship, Radiation; Female; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, SCID; Pentetic Acid; Radioisotopes; Radiopharmaceuticals; Yttrium Radioisotopes | 1999 |
In vivo comparison of CHX-DTPA ligand isomers in athymic mice bearing carcinoma xenografts.
Topics: Animals; Antibodies, Monoclonal; Colonic Neoplasms; Humans; Indium Radioisotopes; Isomerism; Isothiocyanates; Ligands; Mice; Mice, Nude; Pentetic Acid; Radioimmunotherapy; Radiopharmaceuticals; Tissue Distribution; Transplantation, Heterologous; Yttrium Radioisotopes | 1999 |
Labeling anti-HER2/neu monoclonal antibodies with 111In and 90Y using a bifunctional DTPA chelating agent.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Female; Humans; Immunoconjugates; Immunoglobulin G; Indium Radioisotopes; Isothiocyanates; Isotope Labeling; Pentetic Acid; Receptor, ErbB-2; Stereoisomerism; Tumor Cells, Cultured; Yttrium Radioisotopes | 2003 |
A single treatment of yttrium-90-labeled CHX-A"-C6.5 diabody inhibits the growth of established human tumor xenografts in immunodeficient mice.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Immunoglobulin Variable Region; Immunotoxins; Isothiocyanates; Mice; Mice, Nude; Mice, SCID; Ovarian Neoplasms; Pentetic Acid; Radioimmunotherapy; Radionuclide Imaging; Receptor, ErbB-2; Tissue Distribution; Xenograft Model Antitumor Assays; Yttrium Radioisotopes | 2004 |
Identification of a novel prostate tumor target, mindin/RG-1, for antibody-based radiotherapy of prostate cancer.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Specificity; Bone Neoplasms; CHO Cells; Cricetinae; Dose-Response Relationship, Immunologic; Extracellular Matrix Proteins; Humans; Immunotoxins; Isothiocyanates; Male; Molecular Sequence Data; Pentetic Acid; Positron-Emission Tomography; Prostatic Neoplasms; Radioimmunotherapy; RNA, Messenger; Tissue Distribution; Xenograft Model Antitumor Assays; Yttrium Radioisotopes | 2005 |
Validation of a novel CHX-A'' derivative suitable for peptide conjugation: small animal PET/CT imaging using yttrium-86-CHX-A''-octreotide.
Topics: Animals; Isothiocyanates; Isotope Labeling; Male; Neoplasm Transplantation; Neoplasms, Experimental; Octreotide; Pentetic Acid; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Inbred Lew; Tissue Distribution; Yttrium Radioisotopes | 2006 |
Design, synthesis, and characterization of a dual modality positron emission tomography and fluorescence imaging agent for monoclonal antibody tumor-targeted imaging.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Binding, Competitive; Carbocyanines; Cell Line, Tumor; Chelating Agents; Drug Design; Flow Cytometry; Fluorescent Dyes; Humans; Immunoconjugates; Indium Radioisotopes; Isothiocyanates; Lysine; Pentetic Acid; Positron-Emission Tomography; Radioimmunoassay; Radiopharmaceuticals; Trastuzumab; Yttrium Radioisotopes | 2007 |
In vivo biodistribution, PET imaging, and tumor accumulation of 86Y- and 111In-antimindin/RG-1, engineered antibody fragments in LNCaP tumor-bearing nude mice.
Topics: Animals; Antibodies, Monoclonal; Cell Line, Tumor; Chelating Agents; Humans; Indium Radioisotopes; Isothiocyanates; Male; Mice; Mice, Nude; Neoplasm Transplantation; Pentetic Acid; Positron-Emission Tomography; Prostatic Neoplasms; Radiopharmaceuticals; Tissue Distribution; Tomography, X-Ray Computed; Transplantation, Heterologous; Yttrium Radioisotopes | 2009 |
PET imaging of HER1-expressing xenografts in mice with 86Y-CHX-A''-DTPA-cetuximab.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cell Line, Tumor; Cell Transformation, Neoplastic; Cetuximab; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Isothiocyanates; Mice; Neoplasms; Pentetic Acid; Positron-Emission Tomography; Radiochemistry; Yttrium Radioisotopes | 2010 |
PET imaging of tumor angiogenesis in mice with VEGF-A-targeted (86)Y-CHX-A″-DTPA-bevacizumab.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Colorectal Neoplasms; Female; Humans; Immunoconjugates; Isothiocyanates; Mice; Mice, Nude; Neovascularization, Pathologic; Ovarian Neoplasms; Pentetic Acid; Positron-Emission Tomography; Radioimmunoassay; Radiopharmaceuticals; Tissue Distribution; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Yttrium Radioisotopes | 2011 |
HER1-targeted 86Y-panitumumab possesses superior targeting characteristics than 86Y-cetuximab for PET imaging of human malignant mesothelioma tumors xenografts.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibody Specificity; Cetuximab; ErbB Receptors; Flow Cytometry; Humans; Isothiocyanates; Mesothelioma; Mice; Molecular Targeted Therapy; Panitumumab; Pentetic Acid; Positron-Emission Tomography; Time Factors; Tissue Distribution; Xenograft Model Antitumor Assays; Yttrium Radioisotopes | 2011 |
Flow cytometric cell-based assay to preselect antibody constructs for radionuclide conjugation.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Binding, Competitive; Cell Line, Tumor; Cetuximab; Chelating Agents; Drug Carriers; ErbB Receptors; Flow Cytometry; Fluorescence; Humans; Immunoassay; Immunoconjugates; Isothiocyanates; Pentetic Acid; Protein Binding; Radiopharmaceuticals; Yttrium Radioisotopes | 2012 |
Radiolabeled anti-EGFR-antibody improves local tumor control after external beam radiotherapy and offers theragnostic potential.
Topics: Animals; Antibodies, Monoclonal, Humanized; Carcinoma, Squamous Cell; Cell Line, Tumor; Cetuximab; ErbB Receptors; Female; Humans; Immunotoxins; Isothiocyanates; Male; Mice; Mice, Nude; Pentetic Acid; Radioimmunotherapy; Radiopharmaceuticals; Random Allocation; Tissue Distribution; Yttrium Radioisotopes | 2014 |
A comparative evaluation of the chelators H4octapa and CHX-A″-DTPA with the therapeutic radiometal (90)Y.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Chelating Agents; Ethylamines; Female; Isothiocyanates; Isotope Labeling; Mice; Pentetic Acid; Positron-Emission Tomography; Pyridines; Radioimmunotherapy; Tissue Distribution; Trastuzumab; Yttrium Radioisotopes | 2016 |