Page last updated: 2024-09-03

n-(2-(dimethylamino)ethyl)-n-methyl-4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1h-purin-8-yl)benzenesulfonamide and adenosine

n-(2-(dimethylamino)ethyl)-n-methyl-4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1h-purin-8-yl)benzenesulfonamide has been researched along with adenosine in 15 studies

Compound Research Comparison

Studies
(n-(2-(dimethylamino)ethyl)-n-methyl-4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1h-purin-8-yl)benzenesulfonamide)
Trials
(n-(2-(dimethylamino)ethyl)-n-methyl-4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1h-purin-8-yl)benzenesulfonamide)
Recent Studies (post-2010)
(n-(2-(dimethylamino)ethyl)-n-methyl-4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1h-purin-8-yl)benzenesulfonamide)
Studies
(adenosine)
Trials
(adenosine)
Recent Studies (post-2010) (adenosine)
230032,5361,0758,930

Protein Interaction Comparison

ProteinTaxonomyn-(2-(dimethylamino)ethyl)-n-methyl-4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1h-purin-8-yl)benzenesulfonamide (IC50)adenosine (IC50)
high affinity choline transporter 1 isoform aHomo sapiens (human)0.3851
Sodium/nucleoside cotransporter 1Homo sapiens (human)5.5
Sodium/nucleoside cotransporter 2Homo sapiens (human)5.5
Adenosine receptor A3Homo sapiens (human)0.0011
Adenosine receptor A1Homo sapiens (human)0.0023
Equilibrative nucleoside transporter 1Homo sapiens (human)63
Solute carrier family 28 member 3Homo sapiens (human)3.3

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's15 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
López-Novoa, JM; Olivera, A; Tomás, M1
Bunch, FT; Cohen, MV; Downey, JM; Thornton, J1
Correia-de-Sá, P; Ribeiro, JA; Sebastião, AM1
Downey, JM; Liu, GS; Olsson, RA; Stanley, AW; Thornton, J; Van Winkle, DM1
Elphick, M; Godfrey, PP; Powell, T; Taghavi, Z1
Alexander, SP; Curtis, AR; Hill, SJ; Kendall, DA1
Fralix, TA; London, RE; Murphy, E; Steenbergen, C1
Correia-de-Sá, P; Ribeiro, JA1
Auchampach, JA; Gross, GJ1
Alexander, SP; Cooper, JA; Hill, SJ; Horn, EH; Rubin, PC1
Hourani, SM; Prentice, DJ1
Eleno, N; Lopez-Novoa, JM; MacLaughlin, M; Martinez-Salgado, C; Olivera, A1
Florio, C; Rosati, AM; Traversa, U; Vertua, R1
Hourani, SM; Lewis, CD1
Florio, C; Frausin, F; Gaion, RM; Vertua, R1

Other Studies

15 other study(ies) available for n-(2-(dimethylamino)ethyl)-n-methyl-4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1h-purin-8-yl)benzenesulfonamide and adenosine

ArticleYear
Effect of adenosine A1 and A2 agonists and antagonists on cAMP and Ca2+ in cultured rat mesangial cells.
    The American journal of physiology, 1992, Volume: 262, Issue:4 Pt 1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Glomerular Mesangium; Purines; Rats; Sulfonamides; Xanthines

1992
Adenosine is an endogenous protectant against stunning during repetitive ischemic episodes in the heart.
    American heart journal, 1992, Volume: 124, Issue:6

    Topics: Adenosine; Animals; Female; Hemodynamics; Male; Myocardial Contraction; Myocardial Ischemia; Purinergic Antagonists; Purines; Rabbits; Sulfonamides

1992
Inhibitory and excitatory effects of adenosine receptor agonists on evoked transmitter release from phrenic nerve ending of the rat.
    British journal of pharmacology, 1991, Volume: 103, Issue:2

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Diaphragm; In Vitro Techniques; Male; Motor Endplate; Nerve Endings; Neurotransmitter Agents; Phenylisopropyladenosine; Phrenic Nerve; Purines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Sulfonamides; Vasodilator Agents; Xanthines

1991
Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart.
    Circulation, 1991, Volume: 84, Issue:1

    Topics: Adenosine; Animals; Female; Hemodynamics; Male; Myocardial Infarction; Myocardial Reperfusion; Purines; Rabbits; Receptors, Purinergic; Sulfonamides; Theophylline

1991
Chronic carbamazepine down-regulates adenosine A2 receptors: studies with the putative selective adenosine antagonists PD115,199 and PD116,948.
    Psychopharmacology, 1990, Volume: 100, Issue:4

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Brain Chemistry; Caffeine; Carbamazepine; Clonidine; Cyclic AMP; Down-Regulation; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phenylisopropyladenosine; Purines; Receptors, Adrenergic; Sulfonamides; Theophylline; Xanthines

1990
A1 adenosine receptor inhibition of cyclic AMP formation and radioligand binding in the guinea-pig cerebral cortex.
    British journal of pharmacology, 1994, Volume: 113, Issue:4

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Cerebral Cortex; Colforsin; Cyclic AMP; Guinea Pigs; Histamine; In Vitro Techniques; Phenylisopropyladenosine; Phosphatidylinositols; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Radioligand Assay; Receptors, Purinergic P1; Sulfonamides; Vasodilator Agents; Xanthines

1994
Effects of adenosine antagonists on hexose uptake and preconditioning in perfused rat heart.
    The American journal of physiology, 1993, Volume: 265, Issue:4 Pt 1

    Topics: Adenosine; Animals; Deoxyglucose; Hexoses; In Vitro Techniques; Male; Myocardial Stunning; Myocardium; Perfusion; Purines; Rats; Rats, Sprague-Dawley; Sulfonamides; Xanthines

1993
Facilitation of [3H]-ACh release by forskolin depends on A2-adenosine receptor activation.
    Neuroscience letters, 1993, Mar-05, Volume: 151, Issue:1

    Topics: Acetylcholine; Adenosine; Adenosine Deaminase; Adenylyl Cyclases; Animals; Colforsin; Diaphragm; Female; In Vitro Techniques; Male; Nerve Endings; Phenethylamines; Phenylisopropyladenosine; Phrenic Nerve; Purinergic Antagonists; Purines; Rats; Rats, Wistar; Receptors, Purinergic; Sulfonamides; Xanthines

1993
Adenosine A1 receptors, KATP channels, and ischemic preconditioning in dogs.
    The American journal of physiology, 1993, Volume: 264, Issue:5 Pt 2

    Topics: Adenosine; Adenosine Triphosphate; Animals; Blood Glucose; Coronary Circulation; Coronary Disease; Dogs; Female; Glyburide; Hemodynamics; Male; Myocardial Infarction; Myocardial Reperfusion; Potassium Channels; Purines; Receptors, Purinergic; Sulfonamides; Xanthines

1993
Adenosine receptor-induced cyclic AMP generation and inhibition of 5-hydroxytryptamine release in human platelets.
    British journal of clinical pharmacology, 1995, Volume: 40, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adolescent; Adult; Antihypertensive Agents; Cyclic AMP; Humans; Middle Aged; Phenethylamines; Phenylisopropyladenosine; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Agonists; Purines; Receptors, Purinergic P1; Serotonin; Sulfonamides; Theophylline; Vasodilator Agents; Xanthines

1995
Activation of multiple sites by adenosine analogues in the rat isolated aorta.
    British journal of pharmacology, 1996, Volume: 118, Issue:6

    Topics: Adenosine; Animals; Aorta, Thoracic; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Rats; Rats, Wistar; Receptors, Purinergic P1; Sulfonamides; Theophylline; Triazines; Triazoles; Xanthines

1996
Adenosine activates mesangial cell proliferation.
    Cellular signalling, 1997, Volume: 9, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcium; Cell Division; Cells, Cultured; Cyclic AMP; Glomerular Mesangium; Phenylisopropyladenosine; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Rats; Rats, Wistar; Sulfonamides; Theophylline; Thymidine; Xanthines

1997
Inhibitory and excitatory effects of adenosine antagonists on spontaneous locomotor activity in mice.
    Life sciences, 1997, Volume: 60, Issue:17

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antineoplastic Agents; Male; Mice; Motor Activity; Purinergic P1 Receptor Agonists; Purines; Sulfonamides; Theophylline; Xanthines

1997
Involvement of functional antagonism in the effects of adenosine antagonists and L-NAME in the rat isolated heart.
    General pharmacology, 1997, Volume: 29, Issue:3

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adrenergic alpha-Agonists; Animals; Anti-Arrhythmia Agents; Enzyme Inhibitors; Heart; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Phenethylamines; Phenylephrine; Purinergic P1 Receptor Antagonists; Purines; Rats; Rats, Wistar; Sulfonamides; Theophylline; Vasodilator Agents

1997
Amplification of the cyclic AMP response to forskolin in pheochromocytoma PC12 cells through adenosine A(2A) purinoceptors.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:2

    Topics: Adenosine; Adenosine Deaminase; Adenosine Monophosphate; Animals; Colforsin; Cyclic AMP; Inosine; Kinetics; PC12 Cells; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Sulfonamides; Theophylline

1999