n-(1-methyl-5-indolyl)-n--(3-methyl-5-isothiazolyl)urea has been researched along with isoliquiritigenin* in 1 studies
1 other study(ies) available for n-(1-methyl-5-indolyl)-n--(3-methyl-5-isothiazolyl)urea and isoliquiritigenin
| Article | Year |
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Rikkunshito, a Japanese kampo medicine, ameliorates decreased feeding behavior via ghrelin and serotonin 2B receptor signaling in a novelty stress murine model.
We investigated the effects of rikkunshito (RKT), a ghrelin signal enhancer, on the decrease in food intake after exposure to novelty stress in mice. RKT administration (500 mg/kg, per os) improved the decrease in 6 h cumulative food intake. In control mice, the plasma acylated ghrelin levels significantly increased by 24 h fasting. In contrast, the acylated ghrelin levels did not increase by fasting in mice exposed to the novelty stress. RKT administration to the novelty stress mice showed a significant increase in the acylated ghrelin levels compared with that in the distilled-water-treated control mice. Food intake after administering serotonin 2B (5-HT(2B)) receptor antagonists was evaluated to clarify the role of 5-HT(2B) receptor activation in the decrease in feeding behavior after novelty stress. SB215505 and SB204741, 5-HT(2B) receptor antagonists, significantly improved the decrease in food intake after exposure to novelty stress. A component of RKT, isoliquiritigenin, prevented the decrease in 6 h cumulative food intake. Isoliquiritigenin showed 5-HT(2B) receptor antagonistic activity in vitro. In conclusion, the results suggested that RKT improves the decrease in food intake after novelty stress probably via 5-HT(2B) receptor antagonism of isoliquiritigenin contained in RKT. Topics: Animals; Behavior, Animal; Chalcones; Drugs, Chinese Herbal; Eating; Enzyme Inhibitors; Feeding Behavior; Ghrelin; Humans; Indoles; Male; Medicine, Kampo; Mice; Quinolines; Receptor, Serotonin, 5-HT2B; Serotonin 5-HT2 Receptor Antagonists; Stress, Psychological; Urea | 2013 |