n-(1-methyl-2-phenylethyl)adenosine has been researched along with adenosine in 132 studies
| Studies (n-(1-methyl-2-phenylethyl)adenosine) | Trials (n-(1-methyl-2-phenylethyl)adenosine) | Recent Studies (post-2010) (n-(1-methyl-2-phenylethyl)adenosine) | Studies (adenosine) | Trials (adenosine) | Recent Studies (post-2010) (adenosine) |
|---|---|---|---|---|---|
| 134 | 0 | 4 | 32,536 | 1,075 | 8,930 |
| Protein | Taxonomy | n-(1-methyl-2-phenylethyl)adenosine (IC50) | adenosine (IC50) |
|---|---|---|---|
| high affinity choline transporter 1 isoform a | Homo sapiens (human) | 0.3851 | |
| Sodium/nucleoside cotransporter 1 | Homo sapiens (human) | 5.5 | |
| Sodium/nucleoside cotransporter 2 | Homo sapiens (human) | 5.5 | |
| Adenosine receptor A3 | Homo sapiens (human) | 0.0011 | |
| Adenosine receptor A1 | Homo sapiens (human) | 0.0023 | |
| Equilibrative nucleoside transporter 1 | Homo sapiens (human) | 63 | |
| Solute carrier family 28 member 3 | Homo sapiens (human) | 3.3 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (12.88) | 18.7374 |
| 1990's | 59 (44.70) | 18.2507 |
| 2000's | 50 (37.88) | 29.6817 |
| 2010's | 5 (3.79) | 24.3611 |
| 2020's | 1 (0.76) | 2.80 |
| Authors | Studies |
|---|---|
| López-Novoa, JM; Olivera, A; Tomás, M | 1 |
| Lopez-Novoa, JM; Olivera, A | 1 |
| Hammarström, M; Samuelson, UE; Wiklund, NP | 2 |
| Ferin, MA; Lesch, ME; Schrier, DJ; Wright, CD | 1 |
| Beukers, MW; Cragoe, EJ; Garritsen, A; Ijzerman, AP; Soudijn, W | 1 |
| Beukers, MW; Garritsen, A; Ijzerman, AP; Soudijn, W | 1 |
| Gilbertsen, RB; Lesch, ME; Schrier, DJ; Wright, CD | 1 |
| Furth, ED; Goldberg, AP; Rogus, EM; Rolband, GC; Staddon, JM | 1 |
| Cederqvist, B; Gustafsson, LE; Wiklund, NP | 1 |
| Bridges, AJ; Bristol, JA; Bruns, RF; Downs, DA; Heffner, TG; Moos, WH; Szotek, DL; Trivedi, BK | 1 |
| Parsons, WJ; Pierson, G; Stiles, GL; Sunay, S | 1 |
| Olsson, RA; Paton, DM; Thompson, RT | 1 |
| Constantin, L; Martins, JB | 1 |
| Peters, TJ; Shah, T; Simpson, RJ; Webster, AD | 1 |
| Ijzerman, AP; Soudijn, W; van Galen, PJ | 1 |
| Bugni, WJ; Kusachi, S; Olsson, RA; Thompson, RD; Yamada, N | 1 |
| Daly, DT; Olsson, RA; Stiles, GL | 1 |
| Choca, JI; Clark, FM; Green, RD; Proudfit, HK | 1 |
| Heller, LJ; Olsson, RA | 1 |
| Choca, JI; Green, RD; Proudfit, HK | 2 |
| Schnermann, J | 1 |
| Goldberg, SR; Katz, JL | 1 |
| Haleen, SJ; Hamilton, HW; Steffen, RP | 1 |
| Dews, PB; Glowa, JR; Malaspina, S; Sobel, E | 1 |
| Schofield, PR; Townsend-Nicholson, A | 1 |
| Broadley, KJ; Ford, WR | 2 |
| Chopde, CT; Ghosh, AK; Mandhane, SN | 1 |
| Andrés, A; Cubero, A; Fernández, M; Gonzalez-Calero, G; Ros, M; Ruiz, A; Sanz, JM | 1 |
| Buxton, IL; Cheek, DJ; Smith, AD; Westfall, DP | 1 |
| Williams, EF | 1 |
| Lundeberg, T; Segerdahl, M; Sjölund, KF; Sollevi, A | 1 |
| Ali, S; Metzger, WJ; Mustafa, SJ; Olanrewaju, HA | 1 |
| Canela, EI; Ciruela, F; Franco, R; Lluís, C; Mallol, J; Saura, C | 1 |
| Canela, EI; Franco, R; Lluis, C; Mallol, J; Navarro, A; Zapata, R | 2 |
| Pisarenko, OI; Ruuge, EK; Serebryakova, LI; Studneva, IM; Timoshin, AA; Tskitishvily, OV | 1 |
| Henderson, D; Hu, BH; Kopke, RD; McFadden, SL; Zheng, XY | 1 |
| Mainra, RR; Sulakhe, PV; Vo, XT | 1 |
| Hourani, SM; Nicholls, J; Skene, DJ | 1 |
| Hourani, SM; Payne, SL; Prentice, DJ | 1 |
| Barlinski, J; Cano, E; Frossard, N; Lagente, V | 1 |
| Andrés, A; López-Alañon, DM; Ros, M; Sanz, JM; Vacas, J; Vendite, D | 1 |
| Dobson, JG; Fenton, RA; Sawmiller, DR | 1 |
| Kang, L; Ross, S; Wainwright, CL | 1 |
| Betti, L; Biagi, G; Giannaccini, G; Giorgi, I; Livi, O; Lucacchini, A; Manera, C; Scartoni, V | 1 |
| Collins, JG; Kitahata, LM; Maehara, Y; Smith, MA; Sumida, T | 1 |
| Hao, JX; Sjölund, KF; Sollevi, A; von Heijne, M; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Cho, CH; Tang, XL; Wang, HX; Wong, TM | 1 |
| Belardinelli, L; Dennis, DM; Morey, TE | 1 |
| Dice, A; Dineen, B; Dunwiddie, TV; Gilchrist, A; Hamm, HE; Linden, J; Lupica, CR; Mazzoni, MR; Proctor, WR | 1 |
| Amanatullah, DF; Clair, T; Liotta, LA; Schetz, JA; Stracke, ML; Woodhouse, EC | 1 |
| Castel, H; Cazin, L; Mei, YA; Soriani, O; Vaudry, H | 1 |
| Canela, EI; Franco, R; Lluis, C; Mallol, J; Saura, CA | 1 |
| Cui, JG; Linderoth, B; Meyerson, BA; Sollevi, A | 1 |
| Nagai, A; Takeda, Y; Tamaoki, J; Yamawaki, I | 1 |
| Browning, MJ; Hohl, CM; Jurkowitz, MS; Litsky, ML | 1 |
| Graham, DI; Jones, PA; MacGregor, DG; Stone, TW | 1 |
| Black, JW; Meester, BJ; Meijler, FL; Shankley, NP; Welsh, NJ; Wood, J | 1 |
| Cui, JG; Linderoth, B; Meyerson, BA; O'Connor, WT; Segerdahl, M; Sollevi, A; Stiller, CO; Yakhnitsa, V | 1 |
| Caicedo, M; Cepelík, J; Dedina, M; Hynie, S | 1 |
| Cohen, MV; Downey, JM; Hashimi, MW; Thornton, JD | 1 |
| Hao, JX; Sollevi, A; von Heijne, M; Wiesenfeld-Hallin, Z; Xu, XJ; Yu, W | 1 |
| Almaraz, L; Gonzalez, C; Rocher, A | 1 |
| Naghipour, B; Roushan-zamir, F; Shafaghi, B; Zarrindast, MR | 1 |
| Burnside, B; Rey, HL | 1 |
| Kondo, Y; Narita, T; Okajima, F; Sho, K | 1 |
| Jones, BA; Larson, GA; Mayfield, RD; Miller, HA; Simosky, JK; Zahniser, NR | 1 |
| Gandolfi, O; Lucchi, R; Notari, S; Poli, A; Traversa, U; Zampacavallo, G | 1 |
| Gatch, MB; Lal, H; Wallis, CJ | 1 |
| Hou, CJ; Sung, RJ; Tan, HL | 1 |
| Adams, WR; Bharmal, NH; Kaplan, GB; Leite-Morris, KA | 1 |
| Hao, JX; Sollevi, A; von Heijne, M; Xu, XJ | 2 |
| el-Ani, D; Jacobson, KA; Katz, A; Shainberg, A; Zimlichman, R | 1 |
| Headrick, JP; Hinschen, AK; Rose'Meyer, RB | 1 |
| Dixon, AK; Freeman, TC; Lee, K; Preston, Z; Richardson, PJ; Widdowson, L | 1 |
| Agnati, LF; Canela, EI; Casadó, V; Ferré, S; Franco, R; Fuxe, K; Ginés, S; Hillion, J; Le Crom, S; Lew, JY; Lluis, C; Rondin, S; Torvinen, M; Verniera, P; Watson, S; Zoli, M | 1 |
| Boon, K; Hourani, S; Prentice, D | 1 |
| Ghelardoni, S; Ronca, F; Ronca-Testoni, S; Yu, G; Zucchi, R | 1 |
| Boon, K; Fooks, HM; Hourani, SM; Prentice, DJ | 1 |
| Flood, A; Headrick, JP | 1 |
| Honda, Y; Kiryu, J; Miyamoto, K; Nishijima, K; Nishiwaki, H; Nonaka, A; Ogura, Y; Tsujikawa, A; Yamashiro, K | 1 |
| Dar, MS | 1 |
| Breschi, MC; Calderone, V; Martinotti, E; Nieri, P | 1 |
| Homayoun, H; Khavandgar, S; Zarrindast, MR | 1 |
| Bryson, EJ; Stella, SL; Thoreson, WB | 1 |
| Akera, T; Chugun, A; Hara, Y; Kennedy, RH; Klimberg, SV; Sasaki, T; Temma, K; Uchide, T | 1 |
| An, JY; Huh, IH; Kim, TH; Lee, TS; Shim, JO; Shin, CY; Sohn, UD; Song, HJ; Yang, SJ | 1 |
| Gao, ZG; IJzerman, AP; Jacobson, KA; Kim, SG; Melman, N; Soltysiak, KA | 1 |
| Hourani, SM; Kelly, MD; Ledent, C; Prentice, DJ | 1 |
| Broadley, KJ; Martin, TJ | 1 |
| Homayoun, H; Khavandgar, S; Torkaman-Boutorabi, A; Zarrindast, MR | 1 |
| Albasanz, JL; Fernández, M; León, D; Martín, M; Ruíz, MA | 1 |
| Erdmann, A; Gao, ZG; IJzerman, AP; Jacobson, KA; Kim, SG; Melman, N; Müller, CE | 1 |
| Harrison, GJ; Headrick, JP; Rose'Meyer, RB | 1 |
| Ishikawa, T; Kinoshita, H; Lambert, C; Matsui, T; Nakanishi, O; Shinohara, N; Yamamoto, S | 1 |
| Burkard, RF; Henderson, D; Hight, NG; McFadden, SL; Nicotera, T | 1 |
| Fredholm, BB; Hellsten, Y; Lynge, J; Nordsborg, N; Schulte, G | 1 |
| Coelho, JE; Costenla, AR; Cunha, RA; de Mendonça, A; Lopes, LV; Oliveira, CR; Parada, A; Rebola, N; Soares-da-Silva, P | 1 |
| Angulo, E; Canela, EI; Casadó, V; Ferrer, I; Franco, R; Lluis, C; Mallol, J; Viñals, F | 1 |
| Begrow, F; Boknik, P; Hanske, G; Justus, I; Mát'us, M; Matherne, GP; Neumann, J; Reinke, U; Schmitz, W | 1 |
| Casado, FJ; Casadó, V; Duflot, S; Fernández-Veledo, S; Franco, R; Lluís, C; Norman, RI; Pastor-Anglada, M; Riera, B | 1 |
| Jones, B; Ramkumar, V; Rybak, LP; Tsukasaki, N; Whitworth, CA | 1 |
| Dewhurst, S; Fan, S; Gelbard, HA; Hardiek, K; Maggirwar, SB; Maguire, CA; Perry, S; Ramirez, SH; Ramkumar, V | 1 |
| Allen, PB; Brady, AE; Feng, J; Greengard, P; Lefkowitz, RJ; Limbird, LE; Wang, Q; Zhao, J | 1 |
| Bodineau, L; Frugière, A; Gaytan, S; Gros, F; Saadani-Makki, F | 1 |
| Albasanz, JL; Andrés, A; León, D; Martín, M; Ros, M; Ruiz, MA | 1 |
| Baba, K; Fujiwara, H; Kariya, T; Kawai, T; Minatoguchi, S; Takahashi, M; Takemura, G; Uno, Y; Zhang, C | 1 |
| Li, J; Pan, BX; Wang, JL; Wu, ZH | 1 |
| Cavalheiro, EA; da Silva Fernandes, MJ; Doná, F; Ferreira, AT; Vianna, EP | 1 |
| Christopoulos, A; May, LT; Sexton, PM | 1 |
| Jenner, TL; Rose'Meyer, RB | 1 |
| Andoh, T; Echigo, N; Goto, T; Ishiwa, D; Kamiya, Y; Yamada, Y | 1 |
| Antunes-Rodrigues, J; Picanço-Diniz, DL; Valença, MM | 1 |
| Aiba, A; Fredholm, BB; Hashimoto, K; Hashimotodani, Y; Kano, M; Kassai, H; Kawakami, D; Sekino, Y; Tabata, T; Yoshida, T | 1 |
| Daré, E; Fredholm, BB; Johansson, B; Tiselius, C; Valen, G; Yang, JN | 1 |
| Blakely, RD; Daws, LC; Hewlett, WA; Munn, JL; Steiner, JA; Zhu, CB | 1 |
| El-Ani, D; Mashiach, Y; Shainberg, A; Zimlichman, R | 1 |
| Albasanz, JL; Castillo, CA; Iglesias, I; León, DA; Martín, M | 1 |
| Canela, EI; Casadó, V; Cortés, A; Franco, R; García-Sevilla, J; Gracia, E; Herhsfield, MS; Lluís, C; Mallol, J; Meana, JJ | 1 |
| Jun, IG; Park, JY | 1 |
| Correia-de-Sá, P; Oliveira, L; Timóteo, MA | 1 |
| Aurelio, L; Christopoulos, A; Flynn, BL; Scammells, PJ; Sexton, PM; Valant, C | 1 |
| Horiuchi, H; Morino, T; Ogata, T; Yamamoto, H | 1 |
| Aurelio, L; Christopoulos, A; Scammells, PJ; Sexton, PM; Urmaliya, VB; Valant, C; White, P | 1 |
| Fernandes, MJ; Ferrandon, A; Nehlig, A; Persike, DS; Rosim, FE; Silva, IR; Sinigaglia-Coimbra, R; Vignoli, T | 1 |
| Hahm, KD; Jeong, SM; Kim, YK; Lee, C; Leem, JG; Park, PH; Shin, JW; Song, JG | 1 |
| Albasanz, JL; León, DA; Martín, M; Ruiz, MÁ | 1 |
| Jeong, W; Jun, IG; Kim, K; Park, JY | 1 |
132 other study(ies) available for n-(1-methyl-2-phenylethyl)adenosine and adenosine
| Article | Year |
|---|---|
Effect of adenosine A1 and A2 agonists and antagonists on cAMP and Ca2+ in cultured rat mesangial cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Glomerular Mesangium; Purines; Rats; Sulfonamides; Xanthines | 1992 |
Effect of adenosine and adenosine analogues on cyclic AMP accumulation in cultured mesangial cells and isolated glomeruli of the rat.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cells, Cultured; Cyclic AMP; Glomerular Mesangium; Kidney Glomerulus; Purinergic Antagonists; Rats; Rats, Wistar; Vasodilator Agents | 1992 |
Adenosine modulation of neuroeffector transmission in guinea-pig uterine smooth muscle.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Muscle, Smooth; Myometrium; Synaptic Transmission; Theophylline; Uterine Contraction | 1991 |
The effects of (R)-N-(1-methyl-2-phenylethyl) adenosine (L-PIA), a standard A1-selective adenosine agonist on rat acute models of inflammation and neutrophil function.
Topics: Adenosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthus Reaction; Carrageenan; Exudates and Transudates; In Vitro Techniques; Leukocytes; Male; Neutrophils; Oxygen Consumption; Pleurisy; Rats; Rats, Inbred Strains; Receptors, Purinergic; Thromboxane B2 | 1991 |
Effects of adenosine analogues on guinea-pig endometrial secretion.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Dialysis; Electric Stimulation; Endometrium; Estrus; Female; Guinea Pigs; Ovulation; Phentolamine | 1990 |
Interaction of amiloride and its analogues with adenosine A1 receptors in calf brain.
Topics: Adenosine; Amiloride; Animals; Brain; Cattle; GTP-Binding Proteins; Hydrogen-Ion Concentration; In Vitro Techniques; Receptors, Purinergic; Sodium; Sodium Chloride; Structure-Activity Relationship; Xanthines | 1990 |
Chemical modification of adenosine A1 receptors. Implications for the interaction with R-PIA, DPCPX and amiloride.
Topics: Adenosine; Amiloride; Animals; Cattle; Dicyclohexylcarbodiimide; Diethyl Pyrocarbonate; Ethylmaleimide; In Vitro Techniques; Receptors, Purinergic; Structure-Activity Relationship; Xanthines | 1990 |
The antiinflammatory effects of adenosine receptor agonists on the carrageenan-induced pleural inflammatory response in rats.
Topics: Adenosine; Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Captopril; Carrageenan; Clonidine; Leukocyte Count; Minoxidil; Neutrophils; Pleurisy; Rats; Receptors, Purinergic; Superoxides; Theophylline | 1990 |
Effects of age and adenosine in the modulation of insulin action on rat adipocyte metabolism.
Topics: Adenosine; Adipose Tissue; Aging; Animals; Dose-Response Relationship, Drug; Insulin; Isoproterenol; Lipid Metabolism; Lipolysis; Male; Rats; Rats, Inbred Strains | 1990 |
Adenosine enhancement of adrenergic neuroeffector transmission in guinea-pig pulmonary artery.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Male; Norepinephrine; Pulmonary Artery; Receptors, Purinergic; Sympathetic Nervous System; Synaptic Transmission; Theophylline; Vasoconstriction; Vasodilator Agents | 1989 |
N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity.
Topics: Adenosine; Animals; Antipsychotic Agents; Ataxia; Avoidance Learning; Dose-Response Relationship, Drug; Haloperidol; Motor Activity; Rats; Receptors, Purinergic; Structure-Activity Relationship; Thioridazine | 1987 |
The rat testicular A1 adenosine receptor-adenylate cyclase system.
Topics: Adenosine; Adenylyl Cyclases; Affinity Labels; Animals; Colforsin; Guanylyl Imidodiphosphate; Iodine Radioisotopes; Isoproterenol; Male; Phenylisopropyladenosine; Photochemistry; Rats; Rats, Inbred Strains; Receptors, Purinergic; Solubility; Testis | 1986 |
Nature of the N6 region of the adenosine receptor in guinea-pig ileum and rat vas deferens.
Topics: Adenosine; Animals; Cerebral Cortex; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Purinergic; Stereoisomerism; Structure-Activity Relationship; Vas Deferens | 1986 |
Autonomic control of ventricular tachycardia. III. Effects of adenosine and N6-R-1-phenyl-2-propyladenosine.
Topics: Adenosine; Aminophylline; Animals; Dogs; Electric Stimulation; Electrocardiography; Female; Heart Ventricles; Male; Metoprolol; Stellate Ganglion; Sympathetic Nervous System; Tachycardia | 1987 |
Binding of adenosine and receptor-specific analogues to lymphocytes from control subjects and patients with common variable immunodeficiency.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adult; Agammaglobulinemia; Dipyridamole; Erythrocytes; Humans; Lymphocytes | 1987 |
Adenosine derivatives with N6-alkyl, -alkylamine or -alkyladenosine substituents as probes for the A1-receptor.
Topics: Adenosine; Animals; Binding, Competitive; Brain; Cattle; Ligands; Receptors, Purinergic; Stereoisomerism; Structure-Activity Relationship | 1987 |
Dog coronary artery adenosine receptor: structure of the N6-alkyl subregion.
Topics: Adenosine; Animals; Arteries; Blood Pressure; Chemical Phenomena; Chemistry; Coronary Vessels; Dogs; Heart Rate; Isomerism; Molecular Conformation; Receptors, Cell Surface; Receptors, Purinergic; Structure-Activity Relationship | 1985 |
Characterization of the A1 adenosine receptor-adenylate cyclase system of cerebral cortex using an agonist photoaffinity ligand.
Topics: Adenosine; Adenylyl Cyclases; Affinity Labels; Animals; Azides; Cerebral Cortex; Iodine Radioisotopes; Kinetics; Male; Photochemistry; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic | 1986 |
A low-priced computer-assisted densitometer and analysis software for quantitative autoradiography.
Topics: Adenosine; Animals; Autoradiography; Densitometry; Diagnosis, Computer-Assisted; Receptors, Purinergic; Software; Substantia Gelatinosa | 1988 |
Inhibition of rat ventricular automaticity by adenosine.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Animals; Atropine; Depression, Chemical; Electric Stimulation; Electrocardiography; Heart Rate; Heart Ventricles; Male; Propranolol; Rats; Rats, Inbred Strains; Stereoisomerism; Systole; Theophylline | 1985 |
Adenosine A1 and A2 receptors of the substantia gelatinosa are located predominantly on intrinsic neurons: an autoradiography study.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Autoradiography; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, Purinergic; Spinal Cord; Substantia Gelatinosa | 1988 |
Effect of adenosine analogues on tubuloglomerular feedback responses.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Homeostasis; Juxtaglomerular Apparatus; Male; Rats; Rats, Inbred Strains; Receptors, Purinergic | 1988 |
Psychomotor stimulant effects of caffeine alone and in combination with an adenosine analog in the squirrel monkey.
Topics: Adenosine; Amphetamine; Animals; Behavior, Animal; Caffeine; Chlorpromazine; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Food; Male; Motor Activity; Saimiri | 1987 |
Identification of A1 and A2 adenosine receptors in the rat spinal cord.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Analgesia; Animals; Dose-Response Relationship, Drug; Ethylmaleimide; Female; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Purinergic; Spinal Cord | 1987 |
PD 116,948, a highly selective A1 adenosine receptor antagonist.
Topics: Adenosine; Animals; Coronary Circulation; Dose-Response Relationship, Drug; Heart Rate; Rats; Rats, Inbred Strains; Receptors, Purinergic; Xanthines | 1987 |
Behavioral effects of caffeine, (-)N-((R)-1-methyl-2-phenylethyl)-adenosine (PIA), and their combination in the mouse.
Topics: Adenosine; Animals; Caffeine; Conditioning, Operant; Drug Interactions; Food; Light; Male; Mice; Reinforcement Schedule; Sound | 1985 |
A threonine residue in the seventh transmembrane domain of the human A1 adenosine receptor mediates specific agonist binding.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Amino Acid Sequence; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Humans; Kinetics; Mutagenesis, Site-Directed; Point Mutation; Radioligand Assay; Receptors, Purinergic P1; Recombinant Proteins; Stereoisomerism; Theophylline; Threonine; Tritium | 1994 |
Functional classification of P1-purinoceptors in guinea-pig left and right atria: anomalous characteristics of antagonism by cyclopentyltheophylline.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Guinea Pigs; Heart Atria; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline | 1997 |
Adenosine A2 receptors modulate haloperidol-induced catalepsy in rats.
Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Catalepsy; Dopamine Antagonists; Haloperidol; Male; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Scopolamine; Theobromine; Theophylline; Xanthines | 1997 |
Desensitization and internalization of adenosine A1 receptors in rat brain by in vivo treatment with R-PIA: involvement of coated vesicles.
Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Brain; Coated Vesicles; Colforsin; Enzyme Activation; Guanosine Triphosphate; Immunoblotting; Intracellular Membranes; Male; Microsomes; Purinergic P1 Receptor Agonists; Radioligand Assay; Rats; Rats, Wistar; Receptors, Purinergic P1; Vasodilator Agents; Xanthines | 1996 |
Competition of adenine nucleotides for a 1,3-[3H]-dipropyl-8-cyclopentylxanthine binding site in rat vas deferens.
Topics: 2-Chloroadenosine; Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding Sites; Binding, Competitive; In Vitro Techniques; Kinetics; Male; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Vas Deferens; Xanthines | 1997 |
Plasticity of cardiovascular nucleoside transporters following chronic dipyridamole treatment.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Biological Transport; Brain; Cardiovascular System; Cell Membrane; Dipyridamole; Guinea Pigs; Kidney; Male; Myocardium; Nucleosides; Rats; Receptors, Purinergic P1; Thioinosine | 1997 |
Intrathecal adenosine analog administration reduces substance P in cerebrospinal fluid along with behavioral effects that suggest antinociception in rats.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analgesia; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Injections, Spinal; Male; Motor Activity; Pain Threshold; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Reaction Time; Substance P; Theophylline | 1997 |
Adenosine receptor-mediated relaxation of rabbit airway smooth muscle: a role for nitric oxide.
Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Arginine; Bronchi; Dose-Response Relationship, Drug; Epithelium; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Phenethylamines; Potassium Chloride; Purinergic P1 Receptor Agonists; Rabbits; Receptors, Purinergic P1 | 1997 |
Ligand-induced phosphorylation, clustering, and desensitization of A1 adenosine receptors.
Topics: Adenosine; Animals; Binding, Competitive; Cricetinae; Down-Regulation; Fluorescent Antibody Technique; Mesocricetus; Microscopy, Confocal; Muscle, Smooth; Phosphorylation; Receptors, Purinergic P1; Tumor Cells, Cultured; Vasodilator Agents | 1997 |
Regulation of L-type calcium channels in GH4 cells via A1 adenosine receptors.
Topics: Adenosine; Adenosine Deaminase; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Line; Elapid Venoms; Intracellular Membranes; Pituitary Gland; Potassium Chloride; Rats; Receptors, Purinergic P1; Verapamil; Xanthines | 1997 |
Metabolic and antioxidant effects of R(+/-)-N6-(2-phenylisopropyl)-adenosine following regional ischemia and reperfusion in canine myocardium.
Topics: Adenosine; Animals; Antioxidants; Dogs; Female; Hemodynamics; Hydroxyl Radical; Male; Microdialysis; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Spin Labels; Vasodilator Agents | 1997 |
R-phenylisopropyladenosine attenuates noise-induced hearing loss in the chinchilla.
Topics: Adenosine; Animals; Auditory Threshold; Chinchilla; Cochlea; Evoked Potentials, Auditory; Hair Cells, Auditory, Inner; Hair Cells, Auditory, Outer; Hearing Loss, Noise-Induced; Noise; Otoacoustic Emissions, Spontaneous; Reactive Oxygen Species; Time Factors | 1997 |
Differential nature of cross-talk among three G-coupled receptors regulating adenylyl cyclase in rat cardiomyocytes chronically exposed to receptor agonists.
Topics: Adenosine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Carbachol; Cell Culture Techniques; Enzyme Activation; GTP-Binding Proteins; Isoproterenol; Muscarinic Agonists; Myocardium; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Cell Surface; Receptors, Muscarinic; Receptors, Purinergic P1; Vasodilator Agents | 1997 |
Use of a newly developed technique to isolate rat pinealocytes and study the effects of adenosine agonists on melatonin production.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cell Separation; Dose-Response Relationship, Drug; Isoproterenol; Male; Melatonin; Phenethylamines; Pineal Gland; Radioimmunoassay; Rats; Rats, Wistar; Theophylline | 1997 |
Activation of two sites by adenosine receptor agonists to cause relaxation in rat isolated mesenteric artery.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anti-Arrhythmia Agents; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Male; Mesenteric Arteries; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Vasodilation; Vasodilator Agents | 1997 |
Adenosine reduces airway excitatory non-cholinergic (e-NC) contraction through both A1 and A2 adenosine receptor activation in the guinea pig.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Bronchi; Cholinergic Fibers; Dipyridamole; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Substance P; Theobromine; Vasodilator Agents; Xanthines | 1997 |
Desensitization of adenosine A1 receptor-mediated inhibition of adenylyl cyclase in cerebellar granule cells.
Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Cells, Cultured; Cerebellum; GTP-Binding Proteins; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; RNA, Messenger; Signal Transduction | 1998 |
Myocardial adenosine A1-receptor sensitivity during juvenile and adult stages of maturation.
Topics: Adenosine; Adenylyl Cyclases; Adrenergic beta-Agonists; Aging; Animals; Heart; Heart Rate; Isoproterenol; Male; Myocardial Contraction; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Vasodilator Agents; Xanthines | 1998 |
Studies on the mechanism underlying the antifibrillatory effect of the A1-adenosine agonist, R-PIA, in rat isolated hearts.
Topics: Adenosine; Animals; Electrocardiography; Heart Rate; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Vasodilator Agents; Ventricular Fibrillation | 1997 |
Novel 3-aralkyl-7-(amino-substituted)-1,2,3-triazolo[4,5-d]pyrimidines with high affinity toward A1 adenosine receptors.
Topics: Adenosine; Animals; Brain; Cattle; Cell Membrane; Cerebral Cortex; Corpus Striatum; Phenethylamines; Pyridazines; Pyrimidines; Radioligand Assay; Receptor, Adenosine A2A; Receptors, Purinergic P1; Stereoisomerism; Structure-Activity Relationship; Triazoles | 1998 |
Spinal R-phenyl-isopropyl adenosine inhibits spinal dorsal horn neurons responding to noxious heat stimulation in the absence and presence of sensitization.
Topics: Adenosine; Animals; Dose-Response Relationship, Drug; Hot Temperature; Male; Mustard Plant; Neurons, Afferent; Nociceptors; Pain Threshold; Plant Extracts; Plant Oils; Rats; Rats, Sprague-Dawley; Spinal Cord; Theophylline; Vasodilator Agents | 1998 |
Intrathecal administration of the adenosine A1 receptor agonist R-phenylisopropyl adenosine reduces presumed pain behaviour in a rat model of central pain.
Topics: Adenosine; Animals; Behavior, Animal; Cold Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Injections, Spinal; Nociceptors; Pain; Physical Stimulation; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Vasodilator Agents | 1998 |
Reduced responsiveness of [Ca2+]i to adenosine A1- and A2-receptor stimulation in the isoproterenol-stimulated ventricular myocytes of spontaneously hypertensive rats.
Topics: Adenosine; Adrenergic beta-Agonists; Animals; Calcium; Cardiotonic Agents; Electric Stimulation; Heart Ventricles; Isoproterenol; Male; Myocardium; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Theobromine; Vasodilator Agents; Xanthines | 1998 |
Validation of Furchgott's method to determine agonist-dependent A1-adenosine receptor reserve in guinea-pig atrium.
Topics: Adenosine; Animals; Blood Pressure; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Methods; Purinergic P1 Receptor Agonists; Radioligand Assay; Receptors, Purinergic P1; Xanthines | 1998 |
Antagonists of the receptor-G protein interface block Gi-coupled signal transduction.
Topics: Adenosine; Animals; Baclofen; Binding, Competitive; Brain; Cells, Cultured; Electrophysiology; GTP-Binding Proteins; Humans; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Purinergic P1; Rhodopsin; Signal Transduction; Xanthines | 1998 |
Adenosine receptor mediates motility in human melanoma cells.
Topics: Adenosine; Adenosine Monophosphate; Animals; Chemotaxis; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Melanoma, Experimental; Pertussis Toxin; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Transfection; Virulence Factors, Bordetella; Xanthines | 1998 |
Adenosine potentiates the delayed-rectifier potassium conductance but has no effect on the hyperpolarization-activated Ih current in frog melanotrophs.
Topics: Adenosine; Animals; Cells, Cultured; Cyclic Nucleotide-Gated Cation Channels; Delayed Rectifier Potassium Channels; Drug Synergism; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ion Channels; Male; Melanocyte-Stimulating Hormones; Membrane Potentials; Neuroprotective Agents; Patch-Clamp Techniques; Pituitary Gland; Potassium Channels; Potassium Channels, Voltage-Gated; Purinergic P1 Receptor Agonists; Rana ridibunda | 1998 |
Adenosine deaminase and A1 adenosine receptors internalize together following agonist-induced receptor desensitization.
Topics: Adenosine; Adenosine Deaminase; Animals; Cell Line; Cell Membrane; Cricetinae; Endocytosis; Flow Cytometry; Immunohistochemistry; Male; Mesocricetus; Microscopy, Confocal; Muscle, Smooth; Phosphorylation; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1 | 1998 |
Effect of spinal cord stimulation on tactile hypersensitivity in mononeuropathic rats is potentiated by simultaneous GABA(B) and adenosine receptor activation.
Topics: Adenosine; Animals; Baclofen; Electric Stimulation; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hindlimb; Hyperesthesia; Male; Phosphinic Acids; Propanolamines; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, Purinergic P1; Sciatic Nerve; Sensory Thresholds; Spinal Cord; Theophylline | 1998 |
[Effect of adenosine and its analogues on microvascular leakage in the rat trachea].
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Male; Neurons, Afferent; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Substance P; Tachykinins; Trachea; Vasodilator Agents | 1998 |
Adenosine, inosine, and guanosine protect glial cells during glucose deprivation and mitochondrial inhibition: correlation between protection and ATP preservation.
Topics: Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Amobarbital; Anaerobiosis; Animals; Astrocytes; Cell Hypoxia; Cell Survival; Coformycin; Dose-Response Relationship, Drug; Electron Transport; Enzyme Inhibitors; GABA Modulators; Glioma; Glucose; Glycolysis; Guanine Nucleotides; Guanosine; Hybrid Cells; Inosine; Inosine Monophosphate; Ischemia; Lactic Acid; Mitochondria; Neuroprotective Agents; Oligodendroglia; Pentosyltransferases; Purine Nucleosides; Rats | 1998 |
Protection by an adenosine analogue against kainate-induced extrahippocampal neuropathology.
Topics: Adenosine; Amygdala; Animals; Brain; Cerebral Cortex; Entorhinal Cortex; Kainic Acid; Male; Rats; Rats, Wistar; Thalamus | 1998 |
Pharmacological classification of adenosine receptors in the sinoatrial and atrioventricular nodes of the guinea-pig.
Topics: Adenosine; Animals; Atrioventricular Node; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Sinoatrial Node; Stereoisomerism | 1998 |
Modulation of spinal pain mechanisms by spinal cord stimulation and the potential role of adjuvant pharmacotherapy.
Topics: Adenosine; Animals; Baclofen; Behavior, Animal; Chemotherapy, Adjuvant; Combined Modality Therapy; Disease Models, Animal; Electric Stimulation Therapy; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Injections, Spinal; Male; Pain; Pain Management; Pain Threshold; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Purinergic P1; Spinal Cord; Touch; Treatment Outcome | 1997 |
Effects of drugs acting on adrenergic and adenosine receptors on the intraocular pressure and the activity of adenylyl cyclase in ciliary processes and their sensitivity to pertussis toxin.
Topics: Adenosine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic Agonists; Adrenergic alpha-Antagonists; Animals; Ciliary Body; Clonidine; Epinephrine; Fenoterol; Intraocular Pressure; Pertussis Toxin; Purinergic P1 Receptor Agonists; Rabbits; Receptors, Adrenergic; Receptors, Purinergic P1; Virulence Factors, Bordetella; Yohimbine | 1997 |
Loss of myocardial protection from ischemic preconditioning following chronic exposure to R(-)-N6-(2-phenylisopropyl)adenosine is related to defect at the adenosine A1 receptor.
Topics: Adenosine; Animals; Carbachol; Down-Regulation; Female; GTP-Binding Proteins; Hemodynamics; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Protein Kinase C; Rabbits; Receptors, Purinergic P1 | 1998 |
Reduced anti-allodynic effect of the adenosine A1-receptor agonist R-phenylisopropyladenosine on repeated intrathecal administration and lack of cross-tolerance with morphine in a rat model of central pain.
Topics: Adenosine; Analgesics; Analgesics, Opioid; Animals; Chronic Disease; Drug Tolerance; Female; Injections, Spinal; Morphine; Pain; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries | 1998 |
Epidermal growth factor (EGF)-induced up-regulation and agonist- and antagonist-induced desensitization and internalization of A1 adenosine receptors in a pituitary-derived cell line.
Topics: Adenosine; Animals; Calcium; Cell Division; Cell Line; Dactinomycin; Epidermal Growth Factor; Flow Cytometry; Immunohistochemistry; Pituitary Gland; Protein Synthesis Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Up-Regulation; Xanthines | 1999 |
Adenosine inhibits L-type Ca2+ current and catecholamine release in the rabbit carotid body chemoreceptor cells.
Topics: Adenosine; Adrenergic alpha-Antagonists; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Carotid Body; Catecholamines; Chemoreceptor Cells; Dose-Response Relationship, Drug; Electrophysiology; Hypoxia; Ion Channel Gating; Membrane Potentials; Neuroprotective Agents; omega-Conotoxin GVIA; Peptides; Potassium; Rabbits; Sodium; Tetrodotoxin; Theophylline; Tritium; Xanthines | 1999 |
Effects of adenosine receptor agents on the expression of morphine withdrawal in mice.
Topics: Adenosine; Analysis of Variance; Animals; Behavior, Animal; Diarrhea; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Substance Withdrawal Syndrome; Theobromine; Xanthines | 1999 |
Adenosine stimulates cone photoreceptor myoid elongation via an adenosine A2-like receptor.
Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Cell Size; Cells, Cultured; Darkness; Light; Neuroprotective Agents; Perciformes; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Retinal Cone Photoreceptor Cells; Theobromine | 1999 |
Effects of K(+)-channel blockers on A1-adenosine receptor-mediated negative inotropy and chronotropy of guinea-pig isolated left and right atria.
Topics: 4-Aminopyridine; Adenosine; Animals; Dose-Response Relationship, Drug; Drug Interactions; Glyburide; Guinea Pigs; Heart Atria; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Potassium Channel Blockers; Receptors, Purinergic P1; Tetraethylammonium; Vasodilator Agents | 1999 |
An adenosine receptor agonist-induced modulation of TSH-dependent cell growth in FRTL-5 thyroid cells mediated by inhibitory G protein, Gi.
Topics: Adenosine; Bucladesine; Cell Cycle; Cell Division; Cell Line; Dose-Response Relationship, Drug; G1 Phase; GTP-Binding Protein alpha Subunits, Gi-Go; Pertussis Toxin; Purinergic P1 Receptor Agonists; Resting Phase, Cell Cycle; S Phase; Thymidine; Thyroid Gland; Thyrotropin; Virulence Factors, Bordetella | 1999 |
Modulation of endogenous GABA release by an antagonistic adenosine A1/dopamineD1 receptor interaction in rat brain limbic regions but not basal ganglia.
Topics: Adenosine; Animals; Basal Ganglia; Benzazepines; Corpus Striatum; Dopamine Agonists; gamma-Aminobutyric Acid; Globus Pallidus; Limbic System; Male; Nucleus Accumbens; Organ Specificity; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Dopamine D1; Receptors, Purinergic P1; Substantia Nigra; Xanthines | 1999 |
Pharmacological characterization of adenosine A1 receptors and its functional role in brown trout (Salmo trutta) brain.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Brain; Cell Membrane; Glutamic Acid; Guanosine Diphosphate; Kinetics; Neuroprotective Agents; Radioligand Assay; Receptors, Purinergic P1; Synaptosomes; Theophylline; Tritium; Trout; Xanthines | 1999 |
The effects of adenosine ligands R-PIA and CPT on ethanol withdrawal.
Topics: Adenosine; Alcohol Drinking; Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Ethanol; Male; Maze Learning; Purinergic P1 Receptor Agonists; Rats; Rats, Long-Evans; Substance Withdrawal Syndrome; Theophylline | 1999 |
Effects of adenosine A1-receptor activation on torsade de pointes in rabbits.
Topics: Adenosine; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Blood Pressure; Drug Interactions; Electrocardiography; Methoxamine; Neuroprotective Agents; Potassium Channels; Propranolol; Quaternary Ammonium Compounds; Rabbits; Torsades de Pointes | 1999 |
Role of adenosine A1 and A2A receptors in the alcohol withdrawal syndrome.
Topics: Adenosine; Animals; Brain; Central Nervous System Depressants; Ethanol; Male; Mice; Phenethylamines; Purinergic P1 Receptor Agonists; Receptor, Adenosine A2A; Receptors, Purinergic P1; Substance Withdrawal Syndrome; Thioinosine | 1999 |
Intrathecal adenosine does not relieve allodynia-like behavior in spinally injured rats.
Topics: Adenosine; Animals; Behavior, Animal; Female; Injections, Spinal; Motor Activity; Neuroprotective Agents; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries | 1999 |
Uptake of glucose analogs reflects the rate of contraction of cultured myocytes.
Topics: 3-O-Methylglucose; Adenosine; Animals; Animals, Newborn; Carbachol; Cardiotonic Agents; Cells, Cultured; Deoxyglucose; Dipyridamole; Dose-Response Relationship, Drug; Glucose; Isoproterenol; Kinetics; Myocardial Contraction; Myocardium; Rats; Temperature; Time Factors; Vasodilator Agents | 1999 |
Age-related changes in A(1)-adenosine receptor-mediated bradycardia.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Aging; Animals; Bradycardia; Enzyme Inhibitors; Male; Rats; Rats, Wistar; Receptors, Purinergic P1; Tritium | 2000 |
Adenosine receptor expression and function in rat striatal cholinergic interneurons.
Topics: Acetylcholine; Adenosine; Adenosine Deaminase; Animals; Baclofen; Bicuculline; Caffeine; Cholinergic Fibers; Corpus Striatum; Dose-Response Relationship, Drug; GABA Antagonists; Gene Expression; Male; Membrane Potentials; Naloxone; Narcotic Antagonists; Neurons; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; RNA, Messenger; Tritium; Xanthines | 2000 |
Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenosine; Animals; Cell Line; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Dimerization; Dopamine Agonists; Fibroblasts; Humans; Mice; Neurons; Precipitin Tests; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Purinergic P1 | 2000 |
Relaxation of mouse isolated aorta to adenosine and its analogues does not involve adenosine A(1), A(2) or A(3) receptors.
Topics: Adenosine; Animals; Aorta; Endothelium, Vascular; Enzyme Inhibitors; Male; Mice; NG-Nitroarginine Methyl Ester; Receptor, Adenosine A3; Receptors, Purinergic P1; Vasodilation; Vasodilator Agents | 2001 |
A3 adenosine receptor stimulation modulates sarcoplasmic reticulum Ca(2+) release in rat heart.
Topics: Adenosine; Animals; Calcium; Dantrolene; Hemodynamics; Male; Muscle Relaxants, Central; Myocardial Reperfusion Injury; Myocardium; Organ Culture Techniques; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1; Ryanodine; Sarcoplasmic Reticulum; Vasodilator Agents | 2001 |
Effects of intrathecal morphine, baclofen, clonidine and R-PIA on the acute allodynia-like behaviours after spinal cord ischaemia in rats.
Topics: Adenosine; Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Baclofen; Behavior, Animal; Clonidine; Female; GABA Agonists; Injections, Spinal; Ischemia; Morphine; Neuralgia; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sodium Chloride; Spinal Cord | 2001 |
Role of cyclic nucleotides in vasodilations of the rat thoracic aorta induced by adenosine analogues.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Male; Nitroprusside; Nucleotides, Cyclic; Oxadiazoles; Purinones; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 2001 |
Functional characterization of coronary vascular adenosine receptors in the mouse.
Topics: 2-Chloroadenosine; Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Coronary Vessels; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Heart; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase; Nitroarginine; Phenethylamines; Potassium Channel Blockers; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Vascular Resistance; Vasodilation; Vasodilator Agents | 2001 |
Inhibitory effect of ischemic preconditioning on leukocyte participation in retinal ischemia-reperfusion injury.
Topics: Acridine Orange; Adenosine; Animals; Fluorescein Angiography; Fluorescent Dyes; Injections, Intramuscular; Ischemic Preconditioning; Leukocytes; Male; Models, Animal; Purinergic P1 Receptor Antagonists; Rats; Rats, Long-Evans; Receptors, Purinergic P1; Reperfusion Injury; Retinal Diseases; Retinal Vessels; Xanthines | 2001 |
Modulation of ethanol-induced motor incoordination by mouse striatal A(1) adenosinergic receptor.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Affinity Labels; Animals; Antihypertensive Agents; Ataxia; Azides; Benzodiazepines; Central Nervous System Depressants; Corpus Striatum; Ethanol; Male; Mice; Mice, Inbred ICR; Microinjections; Motor Activity; Pertussis Toxin; Phenethylamines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Vasodilator Agents; Virulence Factors, Bordetella; Xanthines | 2001 |
Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Pressure; Diphenhydramine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Heart Rate; Hypotension; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Vasodilator Agents; Xanthines | 2001 |
Effects of adenosine receptor agonists and antagonists on pentylenetetrazole-induced amnesia.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Amnesia; Analysis of Variance; Animals; Avoidance Learning; Convulsants; Dose-Response Relationship, Drug; Male; Mice; Pentylenetetrazole; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Retention, Psychology; Theophylline | 2001 |
A2 adenosine receptors inhibit calcium influx through L-type calcium channels in rod photoreceptors of the salamander retina.
Topics: Adenosine; Adenosine Triphosphate; Animals; Calcium; Calcium Channels, L-Type; Cell Separation; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Dyes; In Vitro Techniques; Ion Transport; Patch-Clamp Techniques; Potassium; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Retina; Retinal Rod Photoreceptor Cells; Signal Transduction; Urodela | 2002 |
Doxorubicin affects the cardiac muscarinic system in the rat.
Topics: Adenosine; Animals; Antineoplastic Agents; Binding, Competitive; Carbachol; Cardiotonic Agents; Depression, Chemical; Doxorubicin; Drug Interactions; Heart; In Vitro Techniques; Muscarinic Antagonists; Myocardial Contraction; Purinergic P1 Receptor Agonists; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Vasodilator Agents | 2001 |
Signal transduction mechanism via adenosine A1 receptor in the cat esophageal smooth muscle cells.
Topics: Adenosine; Animals; Calcium Channels; Cats; Cells, Cultured; Dose-Response Relationship, Drug; Esophagus; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; Heparin; Inositol 1,4,5-Trisphosphate Receptors; Isoenzymes; Muscle Contraction; Muscle, Smooth; Pertussis Toxin; Phospholipase C beta; Phospholipases; Proto-Oncogene Proteins; Purinergic P1 Receptor Agonists; Receptors, Cytoplasmic and Nuclear; Receptors, Purinergic P1; Signal Transduction; Type C Phospholipases; Virulence Factors, Bordetella | 2002 |
Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives.
Topics: Adenosine; Allosteric Regulation; Animals; Binding, Competitive; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Imidazoles; Iodine Radioisotopes; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Quinolines; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazines; Triazoles; Tritium; Xanthines | 2002 |
Relaxation of the mouse isolated aorta and carotid artery in response to adenosine analogues in genetically-modified mice lacking the adenosine A(2A) receptor.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aorta; Carotid Arteries; In Vitro Techniques; Logistic Models; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Phenylephrine; Receptor, Adenosine A2A; Receptors, Purinergic P1; Vasodilation; Vasodilator Agents | 2002 |
Contractile responses to adenosine, R-PIA and ovalbumen in passively sensitized guinea-pig isolated airways.
Topics: Adenosine; Animals; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Immune Sera; In Vitro Techniques; Isotonic Solutions; Methacholine Chloride; Muscle Contraction; Ovalbumin; Purinergic P1 Receptor Agonists; Receptor, Adenosine A3; Time Factors; Trachea; Vasodilator Agents | 2002 |
The effects of adenosine receptor agonists and antagonists on morphine state-dependent memory of passive avoidance.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analgesics, Opioid; Animals; Learning; Male; Memory; Mice; Morphine; Receptors, Purinergic P1; Theophylline; Vasodilator Agents | 2002 |
Adenosine A1 receptor agonist treatment up-regulates rat brain metabotropic glutamate receptors.
Topics: Adenosine; Animals; Brain; Male; Neuroprotective Agents; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; Signal Transduction; Type C Phospholipases; Up-Regulation | 2002 |
Differential allosteric modulation by amiloride analogues of agonist and antagonist binding at A(1) and A(3) adenosine receptors.
Topics: Adenosine; Allosteric Regulation; Amiloride; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diuretics; Dose-Response Relationship, Drug; Drug Interactions; Humans; Imidazoles; Kinetics; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Radioligand Assay; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Transfection; Tritium; Xanthines | 2003 |
Enhanced adenosine A(2B) mediated coronary response in reserpinised rat heart.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Flavins; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Myocardium; Norepinephrine; Purines; Rats; Rats, Wistar; Reperfusion; Reserpine; Time Factors; Tyramine; Vasodilator Agents | 2003 |
Intrathecal adenosine A1 receptor agonist attenuates hyperalgesia without inhibiting spinal glutamate release in the rat.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Glutamic Acid; Hyperalgesia; Injections, Spinal; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Spinal Cord | 2003 |
Noise-induced hearing loss in chinchillas pre-treated with glutathione monoethylester and R-PIA.
Topics: Adenosine; Animals; Antioxidants; Auditory Threshold; Chinchilla; Drug Synergism; Glutathione; Hair Cells, Auditory, Inner; Hair Cells, Auditory, Outer; Hearing Loss, Noise-Induced; Noise; Reactive Oxygen Species | 2003 |
Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cells, Cultured; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phenethylamines; Phosphorylation; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Purinergic P1; RNA; Triazines; Triazoles | 2003 |
Decrease of adenosine A1 receptor density and of adenosine neuromodulation in the hippocampus of kindled rats.
Topics: Adenosine; Adenosine Triphosphate; Animals; Blotting, Western; Electrophysiology; Excitatory Postsynaptic Potentials; Hippocampus; Immunohistochemistry; Kindling, Neurologic; Long-Term Potentiation; Male; Neuroprotective Agents; Organ Culture Techniques; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Synaptic Transmission; Synaptosomes; Xanthines | 2003 |
A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Blotting, Western; Brain; Case-Control Studies; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Flavonoids; Humans; Immunohistochemistry; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Phosphorylation; Receptor, Adenosine A1; Receptors, Adenosine A2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staining and Labeling; tau Proteins; Time Factors; Translocation, Genetic; Tubulin; Xanthines | 2003 |
Altered signal transduction in cardiac ventricle overexpressing A(1)-adenosine receptors.
Topics: Adenosine; Animals; Calcium; Calcium Channels; Calcium-Binding Proteins; Cardiotonic Agents; Cell Size; Heart Ventricles; Isoproterenol; Mice; Mice, Transgenic; Myocytes, Cardiac; Phosphorylation; Rats; Receptors, Purinergic P1; Signal Transduction; Stimulation, Chemical | 2003 |
ATP-sensitive K(+) channels regulate the concentrative adenosine transporter CNT2 following activation by A(1) adenosine receptors.
Topics: Adenosine; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Membrane; Glucose; Hepatocytes; Liver Neoplasms; Male; Membrane Transport Proteins; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Protein Isoforms; Protein Subunits; Purine Nucleosides; Rats; Rats, Wistar; Receptor, Adenosine A1 | 2004 |
Protection against cisplatin ototoxicity by adenosine agonists.
Topics: Adenosine; Animals; Antineoplastic Agents; Chinchilla; Cisplatin; Cochlea; Disease Models, Animal; Hearing Disorders; Lipid Peroxidation; Male; Neuroprotective Agents; Phenethylamines; Receptors, Purinergic P1 | 2004 |
Activation of adenosine A2A receptor protects sympathetic neurons against nerve growth factor withdrawal.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Deaminase; Animals; Animals, Newborn; Apoptosis; Caspases; Cell Survival; Cells, Cultured; Ganglia, Sympathetic; Mitochondria; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Neurons; Neuroprotective Agents; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; RNA, Messenger | 2004 |
Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors.
Topics: Adenosine; Adrenergic alpha-Agonists; Animals; Arrestin; Arrestins; beta-Adrenergic Receptor Kinases; Cell Line; Cyclic AMP-Dependent Protein Kinases; Endocytosis; Enzyme Activation; Epinephrine; G-Protein-Coupled Receptor Kinase 3; GTP-Binding Proteins; Humans; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Mitogen-Activated Protein Kinases; Motor Activity; Nerve Tissue Proteins; Phosphorylation; Receptors, Adrenergic, alpha-2; Rotarod Performance Test; Signal Transduction; Transfection | 2004 |
Involvement of adenosinergic A1 systems in the occurrence of respiratory perturbations encountered in newborns following an in utero caffeine exposure. a study on brainstem-spinal cord preparations isolated from newborn rats.
Topics: Adenosine; Animals; Animals, Newborn; Caffeine; Female; In Vitro Techniques; Medulla Oblongata; Neural Pathways; Pons; Pregnancy; Prenatal Exposure Delayed Effects; Proto-Oncogene Proteins c-fos; Rats; Receptor, Adenosine A1; Respiratory Center; Respiratory Physiological Phenomena; Spinal Cord; Xanthines | 2004 |
Different modulation of inhibitory and stimulatory pathways mediated by adenosine after chronic in vivo agonist exposure.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Binding Sites; Brain; Cell Membrane; Down-Regulation; Drug Administration Schedule; Drug Tolerance; GTP-Binding Protein alpha Subunits, Gs; Male; Neural Inhibition; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Signal Transduction; Synaptic Membranes | 2005 |
Alpha1-receptor or adenosine A1-receptor dependent pathway alone is not sufficient but summation of these pathways is required to achieve an ischaemic preconditioning effect in rabbits.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Enzyme Inhibitors; Heart Rate; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Protein Kinase C; Quinazolines; Rabbits; Receptor, Adenosine A1; Receptors, Adrenergic, alpha-1; Staurosporine; Theophylline; Tyramine; Vasodilator Agents | 2005 |
Adenosine A1 receptors modulate the discharge activities of inspiratory and biphasic expiratory neurons in the medial region of Nucleus Retrofacialis of neonatal rat in vitro.
Topics: Action Potentials; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Animals, Newborn; Brain Stem; Exhalation; In Vitro Techniques; Neurons; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Respiratory Mechanics; Time Factors; Xanthines | 2005 |
Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats.
Topics: 5'-Nucleotidase; Adenosine; Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; In Situ Nick-End Labeling; Male; Neuronal Plasticity; Neuroprotective Agents; Pilocarpine; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Wistar; Receptors, Purinergic P1; Status Epilepticus; Synapses; Triazoles; Xanthines | 2005 |
Effects of urea pretreatment on the binding properties of adenosine A1 receptors.
Topics: Adenosine; Adenosine Deaminase; Animals; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Guanylyl Imidodiphosphate; Humans; Kinetics; Ligands; Protein Denaturation; Receptor, Adenosine A1; Temperature; Transfection; Urea; Xanthines | 2005 |
Loss of vascular adenosine A1 receptors with age in the rat heart.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Age Factors; Aging; Animals; Coronary Circulation; Coronary Vessels; Dose-Response Relationship, Drug; Down-Regulation; Heart; Heart Rate; In Vitro Techniques; Male; Pertussis Toxin; Rats; Rats, Wistar; Receptor, Adenosine A1; Vasoconstriction; Vasodilation; Vasodilator Agents; Ventricular Function, Left; Xanthines | 2006 |
A1 adenosine receptor-mediated modulation of neuronal ATP-sensitive K channels in rat substantia nigra.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine Triphosphate; Animals; Animals, Newborn; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; In Vitro Techniques; Membrane Potentials; Neurons; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Substantia Nigra; Tolbutamide | 2006 |
Adenosine A1 receptor-mediated inhibition of in vitro prolactin secretion from the rat anterior pituitary.
Topics: Adenosine; Animals; Cholera Toxin; Cyclic CMP; Dose-Response Relationship, Drug; Male; Pertussis Toxin; Pituitary Gland, Anterior; Prolactin; Radioimmunoassay; Rats; Rats, Wistar; Receptor, Adenosine A1; Signal Transduction; Type C Phospholipases | 2006 |
G protein-independent neuromodulatory action of adenosine on metabotropic glutamate signalling in mouse cerebellar Purkinje cells.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Calcium; Cells, Cultured; Cerebellum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Fluorometry; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Plasticity; Patch-Clamp Techniques; Purkinje Cells; Receptor Cross-Talk; Receptor, Adenosine A1; Receptors, Metabotropic Glutamate; Signal Transduction | 2007 |
Sex differences in mouse heart rate and body temperature and in their regulation by adenosine A1 receptors.
Topics: Adenosine; Animals; Body Temperature; Caffeine; Central Nervous System Stimulants; Female; Genotype; Heart Rate; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; Receptor, Adenosine A1; Sex Characteristics | 2007 |
Rapid stimulation of presynaptic serotonin transport by A(3) adenosine receptors.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Biological Transport; Cyclic GMP-Dependent Protein Kinases; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A3; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synaptosomes | 2007 |
Adenosine and TNF-alpha exert similar inotropic effect on heart cultures, suggesting a cardioprotective mechanism against hypoxia.
Topics: Adenosine; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Cell Hypoxia; Cell Line; Deoxyglucose; Diazoxide; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Glyburide; Heart; Isoproterenol; Myocardial Contraction; Myocytes, Cardiac; Neuroprotective Agents; Rats; Rubidium Radioisotopes; Sarcoplasmic Reticulum; Tumor Necrosis Factor-alpha | 2007 |
Effect of chronic gestational treatment with the adenosine A1 receptor agonist R-phenylisopropyladenosine on metabotropic glutamate receptors/phospholipase C pathway in maternal and fetal brain.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenylyl Cyclases; Animals; Blotting, Western; Brain; Chromatography, High Pressure Liquid; Female; Fetus; Maternal Exposure; Neuroprotective Agents; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Type C Phospholipases | 2008 |
Human adenosine deaminase as an allosteric modulator of human A(1) adenosine receptor: abolishment of negative cooperativity for [H](R)-pia binding to the caudate nucleus.
Topics: Adenosine; Adenosine Deaminase; Aged; Aged, 80 and over; Allosteric Regulation; Binding, Competitive; Brain Chemistry; Caudate Nucleus; Female; Humans; Male; Neurons; Radioligand Assay; Receptor, Adenosine A1; Species Specificity; Tritium | 2008 |
The interaction of gabapentin and N6-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA) on mechanical allodynia in rats with a spinal nerve ligation.
Topics: Adenosine; Amines; Animals; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Gabapentin; gamma-Aminobutyric Acid; Injections, Spinal; Ligation; Male; Pain; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Spinal Nerves; Xanthines | 2008 |
Negative crosstalk between M1 and M2 muscarinic autoreceptors involves endogenous adenosine activating A1 receptors at the rat motor endplate.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Adenosine; Adenosine A1 Receptor Agonists; Adenosine Deaminase; Animals; Female; Male; Motor Endplate; Neurotransmitter Agents; Nucleoside Transport Proteins; Oxotremorine; Phrenic Nerve; Pirenzepine; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Thioinosine; Tritium; Xanthines | 2009 |
Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Allosteric Regulation; Animals; CHO Cells; Cricetinae; Cricetulus; Extracellular Signal-Regulated MAP Kinases; Humans; Phosphorylation; Thiophenes | 2009 |
Adenosine A1 receptor agonists reduce hyperalgesia after spinal cord injury in rats.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Analgesics; Animals; Disease Models, Animal; Female; Hyperalgesia; Phenethylamines; Rats; Rats, Wistar; Receptor, Adenosine A1; Spinal Cord; Spinal Cord Compression; Treatment Outcome; Xanthines | 2010 |
Delineating the mode of action of adenosine A1 receptor allosteric modulators.
Topics: Adenosine; Allosteric Site; Ligands; Receptor, Adenosine A1; Receptors, G-Protein-Coupled; Signal Transduction; Xanthines | 2010 |
The A1 receptor agonist R-Pia reduces the imbalance between cerebral glucose metabolism and blood flow during status epilepticus: could this mechanism be involved with neuroprotection?
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Cerebrovascular Circulation; Glucose; Male; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Status Epilepticus | 2011 |
Adenosine triphosphate-sensitive potassium channel blockers attenuate the antiallodynic effect of R-PIA in neuropathic rats.
Topics: 4-Aminopyridine; Adenosine; Adenosine Triphosphate; Animals; Glyburide; Humans; Hyperalgesia; Injections, Spinal; Male; Neurons; Pain; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Spinal Nerves | 2011 |
Desensitization of adenosine A(1) receptors in rat immature cortical neurons.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenylyl Cyclases; Animals; Cerebral Cortex; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; Neurons; Rats; Rats, Wistar; Receptor, Adenosine A1; Signal Transduction; Time Factors | 2011 |
Antiallodynic and anti-inflammatory effects of intrathecal R-PIA in a rat model of vincristine-induced peripheral neuropathy.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Cold Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Male; Neuralgia; Neuroprotective Agents; Physical Stimulation; Rats; Rats, Sprague-Dawley; Vincristine | 2020 |