n-((n,n-dimethylamino)ethyl)-5-(n,n-bis(2-chloroethyl)amino)-2,4-dinitrobenzamide has been researched along with tretazicar in 3 studies
| Studies (n-((n,n-dimethylamino)ethyl)-5-(n,n-bis(2-chloroethyl)amino)-2,4-dinitrobenzamide) | Trials (n-((n,n-dimethylamino)ethyl)-5-(n,n-bis(2-chloroethyl)amino)-2,4-dinitrobenzamide) | Recent Studies (post-2010) (n-((n,n-dimethylamino)ethyl)-5-(n,n-bis(2-chloroethyl)amino)-2,4-dinitrobenzamide) | Studies (tretazicar) | Trials (tretazicar) | Recent Studies (post-2010) (tretazicar) |
|---|---|---|---|---|---|
| 5 | 0 | 0 | 205 | 6 | 42 |
| Protein | Taxonomy | n-((n,n-dimethylamino)ethyl)-5-(n,n-bis(2-chloroethyl)amino)-2,4-dinitrobenzamide (IC50) | tretazicar (IC50) |
|---|---|---|---|
| Nitroreductase A | Escherichia coli O157:H7 | 0.89 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cliffe, S; Denny, WA; Palmer, BD; Wilson, WR | 1 |
| Atwell, GJ; Denny, WA; Palmer, BD; Schultz, D; Wilson, WR; Xu, XZ | 1 |
| Atwell, GJ; Denny, WA; Hogg, A; Patterson, AV; Pruijn, FB; Pullen, SM; Wilson, WR; Yang, S | 1 |
3 other study(ies) available for n-((n,n-dimethylamino)ethyl)-5-(n,n-bis(2-chloroethyl)amino)-2,4-dinitrobenzamide and tretazicar
| Article | Year |
|---|---|
Hypoxia-selective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells.
Topics: Aniline Compounds; Aniline Mustard; Animals; Antineoplastic Agents; Cell Survival; Chemical Phenomena; Chemistry, Physical; CHO Cells; Cricetinae; Humans; Molecular Structure; Mustard Compounds; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Oxygen; Rats; Solubility; Structure-Activity Relationship; Tumor Cells, Cultured; Water | 1992 |
Hypoxia-selective antitumor agents. 9. Structure-activity relationships for hypoxia-selective cytotoxicity among analogues of 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
Topics: Aniline Mustard; Animals; Antineoplastic Agents; Cell Hypoxia; CHO Cells; Cricetinae; NAD(P)H Dehydrogenase (Quinone); Rats; Structure-Activity Relationship | 1994 |
Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy.
Topics: Animals; Antineoplastic Agents, Alkylating; Bystander Effect; Cell Line, Tumor; Drug Screening Assays, Antitumor; Enzyme Activation; Escherichia coli Proteins; Female; Genetic Therapy; Humans; Least-Squares Analysis; Male; Mice; Mice, Nude; Multivariate Analysis; Nitrogen Mustard Compounds; Nitroreductases; Prodrugs; Quantitative Structure-Activity Relationship; Transplantation, Heterologous | 2007 |