n-((2-dimethylamino)ethyl)-9-aminoacridine-4-carboxamide has been researched along with amsacrine in 4 studies
*Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent. [MeSH]
*Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent. [MeSH]
| Studies (n-((2-dimethylamino)ethyl)-9-aminoacridine-4-carboxamide) | Trials (n-((2-dimethylamino)ethyl)-9-aminoacridine-4-carboxamide) | Recent Studies (post-2010) (n-((2-dimethylamino)ethyl)-9-aminoacridine-4-carboxamide) | Studies (amsacrine) | Trials (amsacrine) | Recent Studies (post-2010) (amsacrine) |
|---|---|---|---|---|---|
| 15 | 0 | 1 | 1,293 | 127 | 120 |
| Protein | Taxonomy | n-((2-dimethylamino)ethyl)-9-aminoacridine-4-carboxamide (IC50) | amsacrine (IC50) |
|---|---|---|---|
| Solute carrier family 22 member 1 | Homo sapiens (human) | 5 | |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | 7.43 | |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | 5.47 | |
| 5-hydroxytryptamine receptor 7 | Cavia porcellus (domestic guinea pig) | 5 | |
| DNA topoisomerase 2-beta | Homo sapiens (human) | 1.88 | |
| Aldehyde oxidase | Homo sapiens (human) | 3.2 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 0.2095 | |
| Aldehyde oxidase 1 | Rattus norvegicus (Norway rat) | 6.4 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baguley, BC; Denny, WA; Rewcastle, GW | 1 |
| Chetcuti, P; Denny, WA; Wakelin, LP | 1 |
| Atwell, GJ; Baguley, BC; Denny, WA; Finlay, GJ; Gamage, SA; Spicer, JA | 1 |
| Bu, X; Eleftheriou, A; He, Z; Qing, Z; Stewart, BW; Wakelin, LP; Zihlif, M | 1 |
4 other study(ies) available for n-((2-dimethylamino)ethyl)-9-aminoacridine-4-carboxamide and amsacrine
| Article | Year |
|---|---|
Potential antitumor agents. 59. Structure-activity relationships for 2-phenylbenzimidazole-4-carboxamides, a new class of "minimal" DNA-intercalating agents which may not act via topoisomerase II.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Cell Survival; Chemical Phenomena; Chemistry, Physical; DNA; Intercalating Agents; Leukemia P388; Mice; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1990 |
Kinetic and equilibrium binding studies of amsacrine-4-carboxamides: a class of asymmetrical DNA-intercalating agents which bind by threading through the DNA helix.
Topics: Amides; Amsacrine; Antineoplastic Agents; DNA; Indicators and Reagents; Intercalating Agents; Kinetics; Molecular Structure; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Structure-Activity Relationship | 1990 |
Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
Topics: Acridines; Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Enzyme Inhibitors; Leukemia; Leukemia P388; Lung Neoplasms; Mice; Molecular Structure; Neoplasm Transplantation; Rats; Structure-Activity Relationship; Topoisomerase I Inhibitors; Tumor Cells, Cultured | 1997 |
DNA threading bis(9-aminoacridine-4-carboxamides): effects of piperidine sidechains on DNA binding, cytotoxicity and cell cycle arrest.
Topics: Aminoacridines; Cell Cycle; Cell Line, Tumor; Dimerization; DNA; Humans; Molecular Structure; Piperidines; Structure-Activity Relationship | 2008 |