Compounds > n-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2-3-dimethoxybenzamide

n-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2-3-dimethoxybenzamide and 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane

n-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2-3-dimethoxybenzamide has been researched along with 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane* in 1 studies

Other Studies

1 other study(ies) available for n-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2-3-dimethoxybenzamide and 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane

Article	Year
Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat brains in vivo using consecutive PET scans of [18F]FPCIT and [18F]fallypride. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2012, Volume: 70, Issue:12 The aim of this study was to investigate dopaminergic function in unilaterally lesioned 6-OHDA rats by dual PET radioligands: [(18)F]FPCIT (a dopamine transporter imaging radioligand) and [(18)F]fallypride (a dopamine D2 receptors imaging radioligand). As a result, the brain uptake of [(18)F]FPCIT was significantly reduced and that of [(18)F]fallypride was increased in the ipsilateral striatum (lesion side) of the 6-OHDA rats. These findings implicated that dopamine transporter is down-regulated and dopamine D2 receptor is up-regulated in this hemiparkinsonian rat model. Topics: Animals; Benzamides; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Down-Regulation; Fluorine Radioisotopes; Male; Oxidopamine; Parkinsonian Disorders; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Tomography, Emission-Computed, Single-Photon; Tropanes; Up-Regulation	2012

Article

Year

Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat brains in vivo using consecutive PET scans of [18F]FPCIT and [18F]fallypride.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2012, Volume: 70, Issue:12

The aim of this study was to investigate dopaminergic function in unilaterally lesioned 6-OHDA rats by dual PET radioligands: [(18)F]FPCIT (a dopamine transporter imaging radioligand) and [(18)F]fallypride (a dopamine D2 receptors imaging radioligand). As a result, the brain uptake of [(18)F]FPCIT was significantly reduced and that of [(18)F]fallypride was increased in the ipsilateral striatum (lesion side) of the 6-OHDA rats. These findings implicated that dopamine transporter is down-regulated and dopamine D2 receptor is up-regulated in this hemiparkinsonian rat model.

Topics: Animals; Benzamides; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Down-Regulation; Fluorine Radioisotopes; Male; Oxidopamine; Parkinsonian Disorders; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Tomography, Emission-Computed, Single-Photon; Tropanes; Up-Regulation

2012