n(omega)-hydroxyarginine has been researched along with citrulline in 34 studies
| Studies (n(omega)-hydroxyarginine) | Trials (n(omega)-hydroxyarginine) | Recent Studies (post-2010) (n(omega)-hydroxyarginine) | Studies (citrulline) | Trials (citrulline) | Recent Studies (post-2010) (citrulline) |
|---|---|---|---|---|---|
| 139 | 0 | 24 | 4,572 | 195 | 1,537 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 20 (58.82) | 18.2507 |
| 2000's | 10 (29.41) | 29.6817 |
| 2010's | 4 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boucher, JL; Delaforge, M; Genet, A; Henry, Y; Mansuy, D; Vadon, S | 1 |
| Boucher, JL; Delaforge, M; Genet, A; Mansuy, D; Vadon, S | 1 |
| Butler, AR; Ingold, KU; Korth, HG; Sustmann, R; Thater, C | 1 |
| Campos, KL; Giovanelli, J; Kaufman, S | 1 |
| Marletta, MA; Pufahl, RA; Wishnok, JS | 1 |
| Bucher, B; Busse, R; Hecker, M; Schott, C; Stoclet, JC | 1 |
| Abe, KY; Dafoe, DC; Kuo, PC | 1 |
| Chen, Y; Rosazza, JP | 1 |
| Abu-Soud, HM; Ghosh, DK; Stuehr, DJ | 1 |
| Boucher, JL; Delaforge, M; Mansuy, D; Renaud, JP; Vadon, S | 1 |
| Buga, GM; Cederbaum, SD; Ignarro, LJ; Jenkinson, CP; Pervin, S; Rogers, NE; Schmitz, DA; Singh, R | 1 |
| Broca, C; Gross, R; Hillaire-Buys, D; Manteghetti, M; Masiello, P; Ribes, G; Roye, M | 1 |
| Amano, F; Noda, T | 1 |
| Chakder, S; Rattan, S | 1 |
| Abu-Soud, HM; Mayer, B; Presta, A; Stuehr, DJ | 1 |
| Clague, MJ; Marletta, MA; Wishnok, JS | 1 |
| Block, ER; Couch, M; Su, Y | 1 |
| Ash, DE; Dismukes, GC; Khangulov, SV; Sossong, TM | 1 |
| Boucher, JL; Mansuy, D; Moali, C; Sari, MA; Stuehr, DJ | 1 |
| Gachhui, R; Giovanelli, J; Kaufman, S; Stuehr, DJ; Witteveen, CF; Yim, MB | 1 |
| Allers, A; Hattenbach, LO; Hecker, M; Klais, C; Koch, F | 1 |
| Boggs, S; Huang, L; Stuehr, DJ | 1 |
| Beyer, J; Daniel, WG; Garlichs, CD; Mügge, A; Plötze, K; Schellong, S; Schmeisser, A; Zhang, H | 1 |
| Meulemans, A | 1 |
| Iwanaga, T; Kominami, S; Yamazaki, T | 1 |
| Sagami, I; Shimizu, T; Yadav, J | 1 |
| Hartshorne, GM; Kennedy, CR; Mitchell, LM | 1 |
| Clement, B; Kotthaus, J; Schade, D; Töpker-Lehmann, K | 1 |
| Blackwelder, WC; Hazen, SL; Kato, GJ; Machado, RF; Taylor, JG; Wang, Z | 1 |
| Crane, BR; Davydov, R; Hoffman, BM; Lees, NS; Sudhamsu, J | 1 |
| Jansen Labby, K; Li, H; Martásek, P; Poulos, TL; Roman, LJ; Silverman, RB | 1 |
| Chobot, SE; Crane, BR; Davydov, R; Hoffman, BM; Labby, KJ; Lukoyanov, DA; Silverman, RB | 1 |
| Belfield, G; Lewis, R; Narjes, F; Öberg, L; Ripa, L; Shamovsky, I; Sjö, P; Tyrchan, C | 1 |
| Bollenbach, A; Tsikas, D | 1 |
34 other study(ies) available for n(omega)-hydroxyarginine and citrulline
| Article | Year |
|---|---|
Cytochrome P450 catalyzes the oxidation of N omega-hydroxy-L-arginine by NADPH and O2 to nitric oxide and citrulline.
Topics: Animals; Arginine; Carbon Monoxide; Catalysis; Citrulline; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Male; Miconazole; Microsomes, Liver; NADP; Nitric Oxide; Oxidation-Reduction; Oxygen; Rats; Rats, Inbred Strains | 1992 |
Formation of nitrogen oxides and citrulline upon oxidation of N omega-hydroxy-L-arginine by hemeproteins.
Topics: Animals; Arginine; Citrulline; Cytochrome P-450 Enzyme System; Dexamethasone; Hemeproteins; Horseradish Peroxidase; Kinetics; Male; Miconazole; Microsomes, Liver; Nitrogen Oxides; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1992 |
On the mechanism of the nitric oxide synthase-catalyzed conversion of N omega-hydroxyl-L-arginine to citrulline and nitric oxide.
Topics: Amino Acid Oxidoreductases; Arginine; Catalysis; Citrulline; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Temperature | 1994 |
Characteristics of the nitric oxide synthase-catalyzed conversion of arginine to N-hydroxyarginine, the first oxygenation step in the enzymic synthesis of nitric oxide.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Brain; Catalysis; Cell Line; Chromatography, High Pressure Liquid; Citrulline; Humans; Kidney; Kinetics; Nitric Oxide Synthase; Oxidation-Reduction; Rats; Recombinant Proteins; Transfection; Tritium | 1995 |
Hydrogen peroxide-supported oxidation of NG-hydroxy-L-arginine by nitric oxide synthase.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Benzene Derivatives; Cell Line; Citrulline; Hydrogen Peroxide; Kinetics; Macrophages; Mice; NADP; Nitrates; Nitric Oxide Synthase; Nitrites; Oxygen; Peroxides; tert-Butylhydroperoxide | 1995 |
Increase in serum NG-hydroxy-L-arginine in rats treated with bacterial lipopolysaccharide.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Citrulline; Escherichia coli; Lipopolysaccharides; Male; Nitrates; Nitric Oxide Synthase; Nitrites; Rats; Rats, Wistar; Stereoisomerism | 1995 |
Cytochrome P450IIIA activity and cytokine-mediated synthesis of nitric oxide.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Base Sequence; Cimetidine; Citrulline; Cytochrome P-450 Enzyme System; Cytokines; Isomerism; Male; Molecular Probes; Molecular Sequence Data; Nitric Oxide; Nitric Oxide Synthase; Polymerase Chain Reaction; Rats; Rats, Inbred Lew; RNA, Messenger; Transcription, Genetic | 1995 |
Purification and characterization of nitric oxide synthase (NOSNoc) from a Nocardia species.
Topics: Amino Acid Oxidoreductases; Amino Acid Sequence; Arginine; Chromatography, Liquid; Citrulline; Enzyme Stability; Hydrogen-Ion Concentration; Molecular Sequence Data; Molecular Weight; NADP; Nitric Oxide Synthase; Nocardia; Oxidation-Reduction; Oxygen Consumption; Sequence Analysis; Substrate Specificity | 1995 |
Reconstitution of the second step in NO synthesis using the isolated oxygenase and reductase domains of macrophage NO synthase.
Topics: Arginine; Citrulline; Electron Transport; Kinetics; Macrophages; Nitric Oxide; Nitric Oxide Synthase; Oxidoreductases; Oxygenases; Substrate Specificity | 1995 |
Particular ability of liver P450s3A to catalyze the oxidation of N omega-hydroxyarginine to citrulline and nitrogen oxides and occurrence in no synthases of a sequence very similar to the heme-binding sequence in P450s.
Topics: Amino Acid Oxidoreductases; Amino Acid Sequence; Animals; Arginine; Catalysis; Citrulline; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Isoenzymes; Male; Microsomes, Liver; Molecular Sequence Data; Nitric Oxide Synthase; Nitrogen Oxides; Oxidation-Reduction; Rats | 1993 |
Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine during high-output NO production.
Topics: Animals; Arginase; Arginine; Cells, Cultured; Citrulline; Endothelium, Vascular; Enzyme Induction; Male; Nitric Oxide; Rats; Rats, Sprague-Dawley; Urea | 1996 |
Mechanisms involved in the effect of nitric oxide synthase inhibition on L-arginine-induced insulin secretion.
Topics: Animals; Arginase; Arginine; Citrulline; Enzyme Inhibitors; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Rats; Rats, Wistar; Vasodilator Agents | 1997 |
Differences in nitric oxide synthase activity in a macrophage-like cell line, RAW264.7 cells, treated with lipopolysaccharide (LPS) in the presence or absence of interferon-gamma (IFN-gamma): possible heterogeneity of iNOS activity.
Topics: Animals; Arginine; Benzoates; Carbon Radioisotopes; Cell Line; Chromatography, Thin Layer; Citrulline; Dose-Response Relationship, Drug; Enzyme Activation; Imidazoles; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; NADP; Nitric Oxide Synthase; Substrate Specificity; Time Factors | 1997 |
L-arginine deficiency causes suppression of nonadrenergic noncholinergic nerve-mediated smooth muscle relaxation: role of L-citrulline recycling.
Topics: Anal Canal; Animals; Arginase; Arginine; Citrulline; Electric Stimulation; Female; Glutamine; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Opossums | 1997 |
Analysis of neuronal NO synthase under single-turnover conditions: conversion of Nomega-hydroxyarginine to nitric oxide and citrulline.
Topics: Animals; Arginine; Citrulline; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase | 1997 |
Formation of N delta-cyanoornithine from NG-hydroxy-L-arginine and hydrogen peroxide by neuronal nitric oxide synthase: implications for mechanism.
Topics: Animals; Arginine; Cell Line; Chromatography, High Pressure Liquid; Citrulline; Hydrogen Peroxide; Kinetics; Mass Spectrometry; Models, Chemical; Neurons; Nitric Oxide Synthase; Ornithine; Recombinant Proteins; Spodoptera; Substrate Specificity; Transfection | 1997 |
Substrate inhibition of nitric oxide synthase in pulmonary artery endothelial cells in culture.
Topics: Animals; Arginine; Benzoates; Cell Membrane; Cells, Cultured; Citrulline; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; Imidazoles; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Oxyhemoglobins; Pulmonary Artery; Superoxide Dismutase; Swine | 1997 |
L-arginine binding to liver arginase requires proton transfer to gateway residue His141 and coordination of the guanidinium group to the dimanganese(II,II) center.
Topics: Animals; Arginase; Arginine; Asparagine; Binding Sites; Borates; Citrulline; Electron Spin Resonance Spectroscopy; Guanidine; Histidine; Hydrogen-Ion Concentration; Isoleucine; Liver; Lysine; Manganese; Mutagenesis, Site-Directed; Ornithine; Protons; Rats; Substrate Specificity | 1998 |
Substrate specificity of NO synthases: detailed comparison of L-arginine, homo-L-arginine, their N omega-hydroxy derivatives, and N omega-hydroxynor-L-arginine.
Topics: Animals; Arginine; Catalysis; Cattle; Citrulline; Homoarginine; Kinetics; NADP; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Oxygen; Substrate Specificity | 1998 |
Reactivity of the flavin semiquinone of nitric oxide synthase in the oxygenation of arginine to NG-hydroxyarginine, the first step of nitric oxide synthesis.
Topics: Arginine; Citrulline; Electron Spin Resonance Spectroscopy; Flavin-Adenine Dinucleotide; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxygen | 1998 |
L-Arginine-nitric oxide pathway-related metabolites in the aqueous humor of diabetic patients.
Topics: Aged; Aged, 80 and over; Aqueous Humor; Arginine; Chromatography, High Pressure Liquid; Citrulline; Diabetic Retinopathy; Humans; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Up-Regulation | 2000 |
Formation and reactions of the heme-dioxygen intermediate in the first and second steps of nitric oxide synthesis as studied by stopped-flow spectroscopy under single-turnover conditions.
Topics: Animals; Arginine; Catalysis; Citrulline; Ferrous Compounds; Heme; Kinetics; Models, Chemical; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrites; Oxygen; Rats; Spectrophotometry | 2000 |
Decreased plasma concentrations of L-hydroxy-arginine as a marker of reduced NO formation in patients with combined cardiovascular risk factors.
Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Citrulline; Female; Humans; Hyperglycemia; Hyperlipidemias; Hypertension; Male; Mass Spectrometry; Middle Aged; Nitric Oxide; Obesity; Risk Factors; Syndrome | 2000 |
Electrochemical detection of nitroso-arginine as an intermediate between N-hydroxy-arginine and citrulline. An in vitro versus in vivo study using microcarbon electrodes in neuronal nitric oxide synthase and mice brain.
Topics: Animals; Arginine; Brain; Brain Chemistry; Citrulline; Electrochemistry; Mice; Microelectrodes; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrites; Nitroso Compounds; Oxidation-Reduction; Surface Properties | 2000 |
Regulation of the successive reaction catalyzed by rat neuronal nitric oxide synthase.
Topics: Animals; Arginine; Calmodulin; Citrulline; Electron Transport; Gene Expression Regulation, Enzymologic; NADP; Nerve Tissue Proteins; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Recombinant Proteins | 2000 |
Cyanide binding study of neuronal nitric oxide synthase: effects of inhibitors and mutations at the substrate binding site.
Topics: Arginine; Binding Sites; Citrulline; Cyanides; Enzyme Inhibitors; Indazoles; Mutagenesis, Site-Directed; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Spectrophotometry, Ultraviolet; Thiourea | 2003 |
Expression of nitric oxide synthase and effect of substrate manipulation of the nitric oxide pathway in mouse ovarian follicles.
Topics: Animals; Arginine; Citrulline; Culture Media; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Mice; Mice, Inbred Strains; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Ovarian Follicle; Ovulation; RNA, Messenger; Tissue Survival; Transferrin | 2004 |
Synthetic approaches to N(delta)-methylated L-arginine, N(omega)-hydroxy-L-arginine, L-citrulline, and N(delta)-cyano-L-ornithine.
Topics: Arginine; Boron Compounds; Citrulline; Molecular Structure; Ornithine; Oxazolone | 2008 |
Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death.
Topics: Anemia, Sickle Cell; Arginine; Case-Control Studies; Citrulline; Follow-Up Studies; Hemolysis; Humans; Hypertension, Pulmonary; Kidney Diseases; Linear Models; Nitric Oxide Synthase; omega-N-Methylarginine; Oxygen; Proportional Hazards Models; Risk; Survival Rate | 2009 |
EPR and ENDOR characterization of the reactive intermediates in the generation of NO by cryoreduced oxy-nitric oxide synthase from Geobacillus stearothermophilus.
Topics: Arginine; Bacterial Proteins; Catalytic Domain; Citrulline; Electron Spin Resonance Spectroscopy; Ferrous Compounds; Geobacillus stearothermophilus; Heme; Models, Molecular; Nitric Oxide; Nitric Oxide Synthase; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction | 2009 |
Methylated N(ω)-hydroxy-L-arginine analogues as mechanistic probes for the second step of the nitric oxide synthase-catalyzed reaction.
Topics: Animals; Arginine; Catalysis; Chromatography, High Pressure Liquid; Citrulline; Crystallography, X-Ray; Kinetics; Mass Spectrometry; Methylation; Models, Molecular; Molecular Probes; NADP; Nitric Oxide; Nitric Oxide Synthase Type I; Rats; Substrate Specificity | 2013 |
Enzymatic and cryoreduction EPR studies of the hydroxylation of methylated N(ω)-hydroxy-L-arginine analogues by nitric oxide synthase from Geobacillus stearothermophilus.
Topics: Animals; Arginine; Bacterial Proteins; Biocatalysis; Citrulline; Cold Temperature; Electron Spin Resonance Spectroscopy; Geobacillus stearothermophilus; Hydrogen Peroxide; Hydroxylation; Isomerism; Kinetics; Methylation; Mice; Models, Molecular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Protein Stability; Recombinant Proteins; Substrate Specificity | 2014 |
Theoretical studies of the second step of the nitric oxide synthase reaction: Electron tunneling prevents uncoupling.
Topics: Animals; Arginine; Biocatalysis; Biopterins; Catalytic Domain; Citrulline; Conserved Sequence; Databases, Protein; Electron Transport; Humans; Hydrogen Bonding; Models, Molecular; NADP; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidation-Reduction; Protons; Quantum Theory; Thermodynamics | 2018 |
Pharmacological activation of dimethylarginine dimethylaminohydrolase (DDAH) activity by inorganic nitrate and DDAH inhibition by N
Topics: Amidohydrolases; Animals; Arginine; Citrulline; Liver; Nitrates; Rats; Recombinant Proteins | 2019 |