Page last updated: 2024-09-03

n(omega)-hydroxyarginine and arginine

n(omega)-hydroxyarginine has been researched along with arginine in 130 studies

Compound Research Comparison

Studies (n(omega)-hydroxyarginine)	Trials (n(omega)-hydroxyarginine)	Recent Studies (post-2010) (n(omega)-hydroxyarginine)	Studies (arginine)	Trials (arginine)	Recent Studies (post-2010) (arginine)
139	0	24	46,388	1,688	11,176

Protein Interaction Comparison

Protein	Taxonomy	n(omega)-hydroxyarginine (IC50)	arginine (IC50)
Cationic amino acid transporter 3	Homo sapiens (human)		283

Research

Studies (130)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	49 (37.69)	18.2507
2000's	58 (44.62)	29.6817
2010's	21 (16.15)	24.3611
2020's	2 (1.54)	2.80

Authors

Authors	Studies
Marletta, MA; Martin, NI; Winter, MB; Woodward, JJ	1
Boucher, JL; Delaforge, M; Genet, A; Henry, Y; Mansuy, D; Vadon, S	1
Boucher, JL; Delaforge, M; Genet, A; Mansuy, D; Vadon, S	1
Hecker, M; Macarthur, H; Sessa, WC; Vane, JR; Zembowicz, A	1
Fukuto, JM; Gulati, P; Wallace, GC	1
Fukuto, JM; Wallace, GC	1
Chénais, B; Lepoivre, M; Tenu, JP; Yapo, A	1
Berton, CC; Bogen, CM; Schott, CA; Stoclet, JC; Vetrovsky, P	1
Butler, AR; Ingold, KU; Korth, HG; Sustmann, R; Thater, C	1
Campos, KL; Giovanelli, J; Kaufman, S	1
Marletta, MA; Pufahl, RA; Wishnok, JS	1
Busse, R; Hecker, M; Hey, C; Nematollahi, H; Racké, K	1
Clement, B; Kämpchen, T; Mordvintcev, P; Mülsch, A; Schnörwangen, E	1
Bucher, B; Busse, R; Hecker, M; Schott, C; Stoclet, JC	1
Abe, KY; Dafoe, DC; Kuo, PC	1
Chen, Y; Rosazza, JP	1
Abu-Soud, HM; Ghosh, DK; Stuehr, DJ	1
Boucher, JL; Delaforge, M; Mansuy, D; Renaud, JP; Vadon, S	1
Klatt, P; Mayer, B; Schmidt, K; Uray, G	1
Bova, MP; Feldman, PL; Fukuto, JM; Stuehr, DJ; Wong, P	1
Boucher, JL; Custot, J; Delaforge, M; Lepoivre, M; Mansuy, D; Tenu, JP; Vadon, S; Yapo, A	1
Ash, DE; Daghigh, F; Fukuto, JM	1
Dennis, MF; Everett, SA; Patel, KB; Stratford, MR; Wardman, P	1
Abdul-Hussain, MN; Hussain, SN; Jia, YL	1
Buga, GM; Cederbaum, SD; Ignarro, LJ; Jenkinson, CP; Pervin, S; Rogers, NE; Schmitz, DA; Singh, R	1
Eichmann, K; Modolell, M; Soler, G	1
Broca, C; Gross, R; Hillaire-Buys, D; Manteghetti, M; Masiello, P; Ribes, G; Roye, M	1
Entlicher, G; Kleschyov, AL; Poindron, P; Stoclet, JC; Vetrovsky, P	1
Amano, F; Noda, T	1
Entlicher, G; Stoclet, JC; Vetrovsky, P	1
Hecker, M; Meyer, J; Richter, N	1
Busse, R; Hecker, M; Meyer, J; Wigand, R	1
Chakder, S; Rattan, S	1
Galloway, MP; West, AR	1
Abu-Soud, HM; Mayer, B; Presta, A; Stuehr, DJ	1
Clague, MJ; Marletta, MA; Wishnok, JS	1
Block, ER; Couch, M; Su, Y	1
Cattell, V; Cook, HT; Tam, FW; Waddington, SN	1
Ash, DE; Dismukes, GC; Khangulov, SV; Sossong, TM	1
Boucher, JL; Mansuy, D; Moali, C; Sari, MA; Stuehr, DJ	1
Gachhui, R; Giovanelli, J; Kaufman, S; Stuehr, DJ; Witteveen, CF; Yim, MB	1
Bauer, PM; Buga, GM; Fukuto, JM; Ignarro, LJ; Wei, LH	1
Marletta, MA; Rusche, KM; Spiering, MM	1
Salzman, AL; Southan, GJ; Szabó, C	1
Southan, GJ; Srinivasan, A	1
Daff, S; Sagami, I; Sato, H; Shimizu, T	1
Hoffman, BM; Huang, H; Martasek, P; Masters, BS; Silverman, RB; Tierney, DL	1
Ash, DE; Baggio, R; Chakder, S; Christianson, DW; Emig, FA; Rattan, S	1
Edmondson, DE; Hurshman, AR; Huynh, BH; Krebs, C; Marletta, MA	1
Allers, A; Hattenbach, LO; Hecker, M; Klais, C; Koch, F	1
Boucher, JL; Brollo, M; Lepoivre, M; Mansuy, D; Moali, C; Tenu, JP	1
Boggs, S; Huang, L; Stuehr, DJ	1
Goodin, DB; Hirst, J	1
Beyer, J; Daniel, WG; Garlichs, CD; Mügge, A; Plötze, K; Schellong, S; Schmeisser, A; Zhang, H	1
Cederbaum, S; Chaudhuri, G; Karimi, A; Pervin, S; Singh, R	1
Bec, N; Gorren, AC; Lange, R; Mayer, B; Schrammel, A; Werner, ER	1
Meulemans, A	2
Iwanaga, T; Kominami, S; Yamazaki, T	1
Corraliza, I; Gómez-Nieto, LC; Iniesta, V	1
Ash, DE; Boucher, JL; Cama, E; Christianson, DW; Colleluori, DM; Cox, JD; Mansuy, D; Pethe, S	1
Boucher, JL; Mansuy, D; Moali, C; Renodon-Corniere, A; Stuehr, DJ	1
Bauer, PM; Buga, GM; del Soldato, P; Ignarro, LJ; Wei, LH; Wu, G	1
Taylor-Robinson, A	1
Hah, JM; Huang, H; Silverman, RB	1
Ash, DE; Colleluori, DM	1
Cosper, NJ; Hori, H; Iwasaki, T; Nishino, T; Scott, RA	1
Attias, R; Boucher, JL; Dijols, S; Lefevre-Groboillot, D; Mansuy, D; Perollier, C; Pethe, S; Stuehr, DJ	1
Chaudhuri, G; Pervin, S; Singh, R; Wu, G	1
Folkerts, G; Muijsers, RB; Nijkamp, FP; Postma, DS; ten Hacken, NH; Van Ark, I	1
George, SE; Gotoh, T; Huang, YC; Mori, M; Que, LG	1
Alonso, C; Carcelén, J; Corraliza, I; Gómez-Nieto, LC; Iniesta, V; Mirón, C; Mohedano, A; Molano, I	1
Brodsky, SV; Chen, J; Goligorsky, DM; Goligorsky, MS; Gross, SS; Hampel, DJ; Li, H	1
Chaudhuri, G; Pervin, S; Singh, R	2
Davydov, R; Dawson, JH; Hoffman, BM; Larukhin, M; Ledbetter-Rogers, A; Martásek, P; Masters, BS; Sono, M	1
Beranova, P; Boucher, JL; Callizot, N; Chalupsky, K; Entlicher, G; Mansuy, D; Muller, B; Schott, C; Stoclet, JC; Vetrovsky, P	1
Boucher, JL; Frapart, YM; Henry, Y; Mahy, JP; Mandon, D; Mansuy, D; Ricoux, R	1
Sagami, I; Shimizu, T; Yadav, J	1
Hemann, C; Hille, R; Stuehr, DJ; Wang, ZQ; Wei, CC	1
Bogdan, C; El-Gayar, S; Pfeilschifter, J; Röllinghoff, M; Thüring-Nahler, H	1
Edmondson, DE; Hurshman, AR; Krebs, C; Marletta, MA	1
Azuma, H; Kihara, K; Masuda, H; Sakai, Y; Yamauchi, Y; Yano, M	1
Hartshorne, GM; Kennedy, CR; Mitchell, LM	1
Furuyama, S; Moriwaki, K; Yasuda, N	1
Cerbán, FM; Coso, OA; Stempin, CC; Tanos, TB	1
Bukhalid, RA; Cameron, KD; Crane, BR; Gibson, DM; Kers, JA; Krasnoff, SB; Loria, R; Wach, MJ; Widom, J	1
Cho, KB; Gauld, JW	1
Chen, H; He, SY; Howe, GA; McCaig, BC; Melotto, M	1
Ash, DE	1
Sallam, MM; Yassin, MM; Zamzam, ML	1
Beranova, P; Boucher, JL; Chalupsky, K; Kleschyov, AL; Mansuy, D; Muller, B; Munzel, T; Schott, C; Stoclet, JC	1
Crane, BR; Pant, K	1
Donzelli, S; Espey, MG; Fukuto, JM; King, SB; Lazzarino, G; Mancardi, D; Miranda, KM; Paolocci, N; Ridnour, LA; Thomas, DD; Tocchetti, CG; Wink, DA	1
Boucher, JL; Brunet, A; David-Dufilho, M; Topal, G; Topal, JL; Walch, L	1
Clement, B; Heberling, S; Kunze, T	1
Kalinchuk, AV; Porkka-Heiskanen, T; Rosenberg, PA; Stenberg, D	1
Kabir, M; Li, D; Rousseau, DL; Stuehr, DJ; Yeh, SR	1
Dolber, PC; Fraser, MO; Yang, Z	1
Behnke, BJ; Delp, MD; Muller-Delp, JM; Spier, SA; Wu, G	1
Clement, B; Kotthaus, J; Schade, D; Töpker-Lehmann, K	1
Andersson, KK; Cederkvist, FH; Gorren, AC; Harbitz, E; Lange, R; Mayer, B; Shimizu, T; Sørlie, M; Zakariassen, H	1
Antosova, M; Nosalova, G; Strapkova, A	1
Andrews, KL; Chin-Dusting, JF; Harris, EE; Huynh, NN	1
Blackwelder, WC; Hazen, SL; Kato, GJ; Machado, RF; Taylor, JG; Wang, Z	1
Kehl, F; Lange, M; Lotz, C; Redel, A; Roewer, N; Smul, TM; Stumpner, J	1
Crane, BR; Davydov, R; Hoffman, BM; Lees, NS; Sudhamsu, J	1
Doukov, T; Li, H; Poulos, TL; Soltis, M	1
Haag, S; Juergens, UR; Matthiesen, S; Racké, K; Warnken, M	1
Boucher, JL; Frapart, Y; Giroud, C; Mansuy, D; Moreau, M; Sagami, I; Shimizu, T	1
Bittner, F; Clement, B; Garbe-Schönberg, D; Havemeyer, A; Kotthaus, J; Mendel, R; Schade, D; Wahl, B	1
Bagi, Z; Beleznai, T; Feher, A; Lansman, SL; Spielvogel, D	1
Antosova, M; Strapkova, A	1
Aloj, SM; Chiaviello, A; Paciello, I; Palumbo, G; Veneziani, BM	1
Brunel, A; Dorlet, P; Santolini, J	1
Chavez, TA; Cline, MR; Toscano, JP	1
Ratha, BK; Srivastava, S	1
Christianson, DW; D'Antonio, EL; Dixit, UG; Hai, Y; Roberts, SC; Ullman, B; Wilson, ME	1
Jansen Labby, K; Li, H; Martásek, P; Poulos, TL; Roman, LJ; Silverman, RB	1
Avliyakulov, NK; Braga, M; Chaudhuri, G; Haykinson, MJ; Martinez, L; Parveen, M; Pervin, S; Singh, R; Singh, V	1
Jo, T; Lavoie-Lamoureux, A; Martin, JG; Risse, PA; Siddiqui, S; Tsuchiya, K	1
Chobot, SE; Crane, BR; Davydov, R; Hoffman, BM; Labby, KJ; Lukoyanov, DA; Silverman, RB	1
Casarotto, PC; Diniz, CR; Joca, SR	1
Clement, B; Girreser, U; Gudd, J; Litty, FA; Schade, D	1
Dorlet, P; Lembrouk, M; Santolini, J; Weisslocker-Schaetzel, M	1
Belfield, G; Lewis, R; Narjes, F; Öberg, L; Ripa, L; Shamovsky, I; Sjö, P; Tyrchan, C	1
Bollenbach, A; Hanff, E; Tsikas, D	1
Bollenbach, A; Tsikas, D	1
Attia, R; Bourjot, M; Girard, C; Messaoud, C; Skhiri, E; Zedet, A	1
Kuroda, T; Matoba, Y; Oda, K; Shimotani, N	1

Reviews

2 review(s) available for n(omega)-hydroxyarginine and arginine

Article	Year
Structure and function of arginases. The Journal of nutrition, 2004, Volume: 134, Issue:10 Suppl Topics: Animals; Arginase; Arginine; Boronic Acids; Catalysis; Enzyme Inhibitors; Humans; Kinetics; Metals; Structure-Activity Relationship	2004
Nitric oxide, N omega-hydroxy-L-arginine and breast cancer. Nitric oxide : biology and chemistry, 2008, Volume: 19, Issue:2 Topics: Apoptosis; Arginine; Breast Neoplasms; Cell Cycle Proteins; Cell Proliferation; Female; Humans; Nitric Oxide	2008

Other Studies

128 other study(ies) available for n(omega)-hydroxyarginine and arginine

Article	Year
4,4-Difluorinated analogues of l-arginine and N(G)-hydroxy-l-arginine as mechanistic probes for nitric oxide synthase. Bioorganic & medicinal chemistry letters, 2009, Mar-15, Volume: 19, Issue:6 Topics: Arginine; Catalysis; Chemistry, Pharmaceutical; Drug Design; Fluorine; Heme; Models, Chemical; Nitric Oxide Synthase; Oxygen; Protein Isoforms; Protein Structure, Tertiary; Structure-Activity Relationship; Substrate Specificity	2009
Cytochrome P450 catalyzes the oxidation of N omega-hydroxy-L-arginine by NADPH and O2 to nitric oxide and citrulline. Biochemical and biophysical research communications, 1992, Sep-16, Volume: 187, Issue:2 Topics: Animals; Arginine; Carbon Monoxide; Catalysis; Citrulline; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Male; Miconazole; Microsomes, Liver; NADP; Nitric Oxide; Oxidation-Reduction; Oxygen; Rats; Rats, Inbred Strains	1992
Formation of nitrogen oxides and citrulline upon oxidation of N omega-hydroxy-L-arginine by hemeproteins. Biochemical and biophysical research communications, 1992, May-15, Volume: 184, Issue:3 Topics: Animals; Arginine; Citrulline; Cytochrome P-450 Enzyme System; Dexamethasone; Hemeproteins; Horseradish Peroxidase; Kinetics; Male; Miconazole; Microsomes, Liver; Nitrogen Oxides; Oxidation-Reduction; Rats; Rats, Inbred Strains	1992
Nitric oxide and another potent vasodilator are formed from NG-hydroxy-L-arginine by cultured endothelial cells. Proceedings of the National Academy of Sciences of the United States of America, 1991, Dec-15, Volume: 88, Issue:24 Topics: Animals; Aorta; Arginine; Biological Assay; Cattle; Cells, Cultured; Endothelium, Vascular; Kinetics; Muscle, Smooth, Vascular; Nitric Oxide; Rabbits; Subcellular Fractions; Superoxides; Vasodilation; Vasodilator Agents	1991
N omega-hydroxy-L-arginine: a novel arginine analog capable of causing vasorelaxation in bovine intrapulmonary artery. Biochemical and biophysical research communications, 1991, Apr-15, Volume: 176, Issue:1 Topics: Animals; Arginine; Cattle; Endothelium, Vascular; In Vitro Techniques; Methylene Blue; Models, Biological; Muscle, Smooth, Vascular; Nitric Oxide; Oxyhemoglobins; Pulmonary Artery; Vasodilation; Vasodilator Agents	1991
Synthesis and bioactivity of N omega-hydroxyarginine: a possible intermediate in the biosynthesis of nitric oxide from arginine. Journal of medicinal chemistry, 1991, Volume: 34, Issue:5 Topics: Arginine; Chemical Phenomena; Chemistry; Nitric Oxide	1991
N omega-hydroxy-L-arginine, a reactional intermediate in nitric oxide biosynthesis, induces cytostasis in human and murine tumor cells. Biochemical and biophysical research communications, 1993, Nov-15, Volume: 196, Issue:3 Topics: Adenocarcinoma; Amino Acid Oxidoreductases; Animals; Arginine; Biological Transport; Cell Division; Cell Line; Cell Survival; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Mammary Neoplasms, Experimental; Mast-Cell Sarcoma; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase; Tumor Cells, Cultured	1993
Exogenous NG-hydroxyl-L-arginine causes nitrite production in vascular smooth muscle cells in the absence of nitric oxide synthase activity. FEBS letters, 1994, Mar-21, Volume: 341, Issue:2-3 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Carrier Proteins; Cells, Cultured; Enzyme Induction; Male; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitrites; Rats; Rats, Wistar	1994
On the mechanism of the nitric oxide synthase-catalyzed conversion of N omega-hydroxyl-L-arginine to citrulline and nitric oxide. The Journal of biological chemistry, 1994, Jul-08, Volume: 269, Issue:27 Topics: Amino Acid Oxidoreductases; Arginine; Catalysis; Citrulline; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Temperature	1994
Characteristics of the nitric oxide synthase-catalyzed conversion of arginine to N-hydroxyarginine, the first oxygenation step in the enzymic synthesis of nitric oxide. The Journal of biological chemistry, 1995, Jan-27, Volume: 270, Issue:4 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Brain; Catalysis; Cell Line; Chromatography, High Pressure Liquid; Citrulline; Humans; Kidney; Kinetics; Nitric Oxide Synthase; Oxidation-Reduction; Rats; Recombinant Proteins; Transfection; Tritium	1995
Hydrogen peroxide-supported oxidation of NG-hydroxy-L-arginine by nitric oxide synthase. Biochemistry, 1995, Feb-14, Volume: 34, Issue:6 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Benzene Derivatives; Cell Line; Citrulline; Hydrogen Peroxide; Kinetics; Macrophages; Mice; NADP; Nitrates; Nitric Oxide Synthase; Nitrites; Oxygen; Peroxides; tert-Butylhydroperoxide	1995
Inhibition of arginase by NG-hydroxy-L-arginine in alveolar macrophages: implications for the utilization of L-arginine for nitric oxide synthesis. FEBS letters, 1995, Feb-13, Volume: 359, Issue:2-3 Topics: Amino Acid Oxidoreductases; Animals; Arginase; Arginine; Cells, Cultured; Female; Lipopolysaccharides; Macrophage Activation; Macrophages, Alveolar; Male; Nitric Oxide; Nitric Oxide Synthase; Rabbits; Rats; Rats, Sprague-Dawley	1995
Synthesis of 15N omega-hydroxy-L-arginine and ESR and 15N-NMR studies for the elucidation of the molecular mechanism of enzymic nitric oxide formation from L-arginine. Archiv der Pharmazie, 1994, Volume: 327, Issue:12 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Electron Spin Resonance Spectroscopy; In Vitro Techniques; Magnetic Resonance Spectroscopy; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitrogen Radioisotopes	1994
Increase in serum NG-hydroxy-L-arginine in rats treated with bacterial lipopolysaccharide. European journal of pharmacology, 1995, Feb-24, Volume: 275, Issue:1 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Citrulline; Escherichia coli; Lipopolysaccharides; Male; Nitrates; Nitric Oxide Synthase; Nitrites; Rats; Rats, Wistar; Stereoisomerism	1995
Cytochrome P450IIIA activity and cytokine-mediated synthesis of nitric oxide. Surgery, 1995, Volume: 118, Issue:2 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Base Sequence; Cimetidine; Citrulline; Cytochrome P-450 Enzyme System; Cytokines; Isomerism; Male; Molecular Probes; Molecular Sequence Data; Nitric Oxide; Nitric Oxide Synthase; Polymerase Chain Reaction; Rats; Rats, Inbred Lew; RNA, Messenger; Transcription, Genetic	1995
Purification and characterization of nitric oxide synthase (NOSNoc) from a Nocardia species. Journal of bacteriology, 1995, Volume: 177, Issue:17 Topics: Amino Acid Oxidoreductases; Amino Acid Sequence; Arginine; Chromatography, Liquid; Citrulline; Enzyme Stability; Hydrogen-Ion Concentration; Molecular Sequence Data; Molecular Weight; NADP; Nitric Oxide Synthase; Nocardia; Oxidation-Reduction; Oxygen Consumption; Sequence Analysis; Substrate Specificity	1995
Reconstitution of the second step in NO synthesis using the isolated oxygenase and reductase domains of macrophage NO synthase. Biochemistry, 1995, Sep-12, Volume: 34, Issue:36 Topics: Arginine; Citrulline; Electron Transport; Kinetics; Macrophages; Nitric Oxide; Nitric Oxide Synthase; Oxidoreductases; Oxygenases; Substrate Specificity	1995
Particular ability of liver P450s3A to catalyze the oxidation of N omega-hydroxyarginine to citrulline and nitrogen oxides and occurrence in no synthases of a sequence very similar to the heme-binding sequence in P450s. Biochemical and biophysical research communications, 1993, Apr-15, Volume: 192, Issue:1 Topics: Amino Acid Oxidoreductases; Amino Acid Sequence; Animals; Arginine; Catalysis; Citrulline; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Isoenzymes; Male; Microsomes, Liver; Molecular Sequence Data; Nitric Oxide Synthase; Nitrogen Oxides; Oxidation-Reduction; Rats	1993
Multiple catalytic functions of brain nitric oxide synthase. Biochemical characterization, cofactor-requirement, and the role of N omega-hydroxy-L-arginine as an intermediate. The Journal of biological chemistry, 1993, Jul-15, Volume: 268, Issue:20 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Brain; Catalysis; Coenzymes; Heme; Hydrolysis; Kinetics; NADP; Nitric Oxide Synthase; Oxidation-Reduction; Substrate Specificity; Swine	1993
Peracid oxidation of an N-hydroxyguanidine compound: a chemical model for the oxidation of N omega-hydroxyl-L-arginine by nitric oxide synthase. Journal of medicinal chemistry, 1993, Sep-03, Volume: 36, Issue:18 Topics: Amidines; Amino Acid Oxidoreductases; Arginine; Chlorobenzoates; Chromatography, Gas; Chromatography, High Pressure Liquid; Hot Temperature; Luminescent Measurements; Models, Chemical; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Piperidines	1993
N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase. Biochemical and biophysical research communications, 1994, Sep-30, Volume: 203, Issue:3 Topics: Animals; Arginase; Arginine; Cattle; Kinetics; Liver; Lysine; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Nitric Oxide; Rats; Rats, Sprague-Dawley; Valine	1994
Inhibition of rat liver arginase by an intermediate in NO biosynthesis, NG-hydroxy-L-arginine: implications for the regulation of nitric oxide biosynthesis by arginase. Biochemical and biophysical research communications, 1994, Jul-15, Volume: 202, Issue:1 Topics: Animals; Arginase; Arginine; Homeostasis; Liver; Molecular Structure; Nitric Oxide; Rats; Structure-Activity Relationship	1994
Oxidative denitrification of N omega-hydroxy-L-arginine by the superoxide radical anion. The Biochemical journal, 1996, Jul-01, Volume: 317 ( Pt 1) Topics: Arginine; Hydrogen-Ion Concentration; Models, Chemical; Nitric Oxide; Nitrites; Oxidation-Reduction; Superoxides	1996
Mechanisms mediating the vasodilatory effects of N-hydroxy-L-arginine in coronary arteries. European journal of pharmacology, 1996, Jun-03, Volume: 305, Issue:1-3 Topics: Animals; Arginine; Calcimycin; Coronary Vessels; In Vitro Techniques; Miconazole; Muscle Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxazines; Swine; Vasodilator Agents	1996
Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine during high-output NO production. The American journal of physiology, 1996, Volume: 271, Issue:5 Pt 2 Topics: Animals; Arginase; Arginine; Cells, Cultured; Citrulline; Endothelium, Vascular; Enzyme Induction; Male; Nitric Oxide; Rats; Rats, Sprague-Dawley; Urea	1996
Oxidation of N(G)-hydroxyl-L-arginine to nitric oxide mediated by respiratory burst: an alternative pathway to NO synthesis. FEBS letters, 1997, Jan-20, Volume: 401, Issue:2-3 Topics: Animals; Arginine; Cells, Cultured; Humans; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Phagocytes; Respiratory Burst; Superoxides	1997
Mechanisms involved in the effect of nitric oxide synthase inhibition on L-arginine-induced insulin secretion. British journal of pharmacology, 1997, Volume: 120, Issue:3 Topics: Animals; Arginase; Arginine; Citrulline; Enzyme Inhibitors; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Rats; Rats, Wistar; Vasodilator Agents	1997
Nitric oxide generation from extracellularly applied NG-hydroxy-L-arginine in LPS-activated RAW 264 macrophages. Biochimica et biophysica acta, 1997, Feb-11, Volume: 1334, Issue:1 Topics: Animals; Arginine; Cell Line; Electron Spin Resonance Spectroscopy; Lipopolysaccharides; Lysine; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase	1997
Differences in nitric oxide synthase activity in a macrophage-like cell line, RAW264.7 cells, treated with lipopolysaccharide (LPS) in the presence or absence of interferon-gamma (IFN-gamma): possible heterogeneity of iNOS activity. Journal of biochemistry, 1997, Volume: 121, Issue:1 Topics: Animals; Arginine; Benzoates; Carbon Radioisotopes; Cell Line; Chromatography, Thin Layer; Citrulline; Dose-Response Relationship, Drug; Enzyme Activation; Imidazoles; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; NADP; Nitric Oxide Synthase; Substrate Specificity; Time Factors	1997
Possible mechanism of nitric oxide production from N(G)-hydroxy-L-arginine or hydroxylamine by superoxide ion. The international journal of biochemistry & cell biology, 1996, Volume: 28, Issue:12 Topics: Animals; Arginine; Cell Line; Hydrogen-Ion Concentration; Hydroxylamine; Hydroxylamines; In Vitro Techniques; Macrophage Activation; Male; Mice; Microsomes, Liver; Nitrates; Nitric Oxide; Nitrites; Oxidation-Reduction; Rats; Rats, Wistar; Solutions; Superoxides; Water	1996
High-performance liquid chromatographic determination of nitric oxide synthase-related arginine derivatives in vitro and in vivo. Analytical biochemistry, 1997, Apr-05, Volume: 247, Issue:1 Topics: Animals; Arginine; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Female; Humans; In Vitro Techniques; Macrophages, Alveolar; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Reference Values; Reproducibility of Results; Sensitivity and Specificity	1997
Increased serum NG-hydroxy-L-arginine in patients with rheumatoid arthritis and systemic lupus erythematosus as an index of an increased nitric oxide synthase activity. Annals of the rheumatic diseases, 1997, Volume: 56, Issue:5 Topics: Acute Disease; Arginine; Arthritis, Rheumatoid; Biomarkers; Enzyme Activation; Feasibility Studies; Female; Humans; Lupus Erythematosus, Systemic; Male; Nitrates; Nitric Oxide Synthase	1997
L-arginine deficiency causes suppression of nonadrenergic noncholinergic nerve-mediated smooth muscle relaxation: role of L-citrulline recycling. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:1 Topics: Anal Canal; Animals; Arginase; Arginine; Citrulline; Electric Stimulation; Female; Glutamine; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Opossums	1997
Inhibition of glutamate reuptake potentiates endogenous nitric oxide-facilitated dopamine efflux in the rat striatum: an in vivo microdialysis study. Neuroscience letters, 1997, Jul-11, Volume: 230, Issue:1 Topics: Animals; Arginine; Corpus Striatum; Dicarboxylic Acids; Dopamine; Glutamic Acid; Infusions, Parenteral; Kinetics; Male; Microdialysis; Neurotransmitter Uptake Inhibitors; Nitric Oxide; Pyrrolidines; Rats; Rats, Sprague-Dawley	1997
Analysis of neuronal NO synthase under single-turnover conditions: conversion of Nomega-hydroxyarginine to nitric oxide and citrulline. Biochemistry, 1997, Sep-09, Volume: 36, Issue:36 Topics: Animals; Arginine; Citrulline; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase	1997
Formation of N delta-cyanoornithine from NG-hydroxy-L-arginine and hydrogen peroxide by neuronal nitric oxide synthase: implications for mechanism. Biochemistry, 1997, Nov-25, Volume: 36, Issue:47 Topics: Animals; Arginine; Cell Line; Chromatography, High Pressure Liquid; Citrulline; Hydrogen Peroxide; Kinetics; Mass Spectrometry; Models, Chemical; Neurons; Nitric Oxide Synthase; Ornithine; Recombinant Proteins; Spodoptera; Substrate Specificity; Transfection	1997
Substrate inhibition of nitric oxide synthase in pulmonary artery endothelial cells in culture. Nitric oxide : biology and chemistry, 1997, Volume: 1, Issue:6 Topics: Animals; Arginine; Benzoates; Cell Membrane; Cells, Cultured; Citrulline; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; Imidazoles; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Oxyhemoglobins; Pulmonary Artery; Superoxide Dismutase; Swine	1997
Arginase activity is modulated by IL-4 and HOArg in nephritic glomeruli and mesangial cells. The American journal of physiology, 1998, Volume: 274, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginase; Arginine; Cholera Toxin; Cyclic AMP; Glomerular Mesangium; Interleukin-1; Interleukin-4; Isoenzymes; Kidney Glomerulus; Macrophages, Peritoneal; Male; Nephritis; Nitrites; Rats; Rats, Inbred Lew	1998
L-arginine binding to liver arginase requires proton transfer to gateway residue His141 and coordination of the guanidinium group to the dimanganese(II,II) center. Biochemistry, 1998, Jun-09, Volume: 37, Issue:23 Topics: Animals; Arginase; Arginine; Asparagine; Binding Sites; Borates; Citrulline; Electron Spin Resonance Spectroscopy; Guanidine; Histidine; Hydrogen-Ion Concentration; Isoleucine; Liver; Lysine; Manganese; Mutagenesis, Site-Directed; Ornithine; Protons; Rats; Substrate Specificity	1998
Substrate specificity of NO synthases: detailed comparison of L-arginine, homo-L-arginine, their N omega-hydroxy derivatives, and N omega-hydroxynor-L-arginine. Biochemistry, 1998, Jul-21, Volume: 37, Issue:29 Topics: Animals; Arginine; Catalysis; Cattle; Citrulline; Homoarginine; Kinetics; NADP; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Oxygen; Substrate Specificity	1998
Reactivity of the flavin semiquinone of nitric oxide synthase in the oxygenation of arginine to NG-hydroxyarginine, the first step of nitric oxide synthesis. Biochemical and biophysical research communications, 1998, Sep-08, Volume: 250, Issue:1 Topics: Arginine; Citrulline; Electron Spin Resonance Spectroscopy; Flavin-Adenine Dinucleotide; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxygen	1998
NG-hydroxy-L-arginine and nitric oxide inhibit Caco-2 tumor cell proliferation by distinct mechanisms. The American journal of physiology, 1998, Volume: 275, Issue:4 Topics: Animals; Aorta; Arginase; Arginine; Caco-2 Cells; Cell Division; Coculture Techniques; DNA; Endothelium, Vascular; Humans; Nitric Oxide; Nitric Oxide Donors; Ornithine; Ornithine Decarboxylase; Oxadiazoles; Polyamines; Putrescine; Quinoxalines; Rats; Spermidine; Spermine; Thymidine; Triazenes; Urea	1998
Reactions catalyzed by tetrahydrobiopterin-free nitric oxide synthase. Biochemistry, 1998, Nov-03, Volume: 37, Issue:44 Topics: Amino Acids; Animals; Arginine; Biopterins; Carbon Monoxide; Catalase; Catalysis; Chromatography, Gel; Enzyme Induction; Escherichia coli; Macrophages; Mice; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Recombinant Proteins; Spectrophotometry, Ultraviolet	1998
Hydroxyguanidines inhibit peroxynitrite-induced oxidation. Free radical biology & medicine, 1998, Nov-15, Volume: 25, Issue:8 Topics: Arginine; Benzoic Acid; Cell Line; Free Radical Scavengers; Guanidines; Hydroxylamines; Hydroxylation; Macrophages; Nitrates; Oxidation-Reduction; Rhodamines	1998
Nitrogen oxides and hydroxyguanidines: formation of donors of nitric and nitrous oxides and possible relevance to nitrous oxide formation by nitric oxide synthase. Nitric oxide : biology and chemistry, 1998, Volume: 2, Issue:4 Topics: Arginine; Chromatography, High Pressure Liquid; Guanidine; Guanidines; Hydroxylamines; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitrogen Oxides; Nitrous Oxide; Spectrophotometry	1998
Autoxidation rates of neuronal nitric oxide synthase: effects of the substrates, inhibitors, and modulators. Biochemical and biophysical research communications, 1998, Dec-30, Volume: 253, Issue:3 Topics: Animals; Arginine; Biopterins; Flow Injection Analysis; Kinetics; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Onium Compounds; Oxidation-Reduction; Rats; Spectrophotometry	1998
ENDOR spectroscopic evidence for the position and structure of NG-hydroxy-L-arginine bound to holo-neuronal nitric oxide synthase. Biochemistry, 1999, Mar-23, Volume: 38, Issue:12 Topics: Arginine; Catalytic Domain; Electron Spin Resonance Spectroscopy; Holoenzymes; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Protein Conformation	1999
Biochemical and functional profile of a newly developed potent and isozyme-selective arginase inhibitor. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:3 Topics: Amino Acids; Aminocaproates; Anal Canal; Animals; Arginase; Arginine; Boron Compounds; Brain; Enzyme Inhibitors; Female; In Vitro Techniques; Isoenzymes; Liver; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide Synthase; Nitroarginine; Opossums; Rectum; Substrate Specificity	1999
Formation of a pterin radical in the reaction of the heme domain of inducible nitric oxide synthase with oxygen. Biochemistry, 1999, Nov-30, Volume: 38, Issue:48 Topics: Arginine; Biopterins; Electron Spin Resonance Spectroscopy; Free Radicals; Heme; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxygen; Pterins	1999
L-Arginine-nitric oxide pathway-related metabolites in the aqueous humor of diabetic patients. Investigative ophthalmology & visual science, 2000, Volume: 41, Issue:1 Topics: Aged; Aged, 80 and over; Aqueous Humor; Arginine; Chromatography, High Pressure Liquid; Citrulline; Diabetic Retinopathy; Humans; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Up-Regulation	2000
Effects of the new arginase inhibitor N(omega)-hydroxy-nor-L-arginine on NO synthase activity in murine macrophages. Nitric oxide : biology and chemistry, 1999, Volume: 3, Issue:6 Topics: Animals; Arginase; Arginine; Cells, Cultured; Enzyme Inhibitors; Interferon-gamma; Kinetics; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Nitric Oxide Synthase; Nitric Oxide Synthase Type II	1999
Formation and reactions of the heme-dioxygen intermediate in the first and second steps of nitric oxide synthesis as studied by stopped-flow spectroscopy under single-turnover conditions. Biochemistry, 2000, Mar-07, Volume: 39, Issue:9 Topics: Animals; Arginine; Catalysis; Citrulline; Ferrous Compounds; Heme; Kinetics; Models, Chemical; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrites; Oxygen; Rats; Spectrophotometry	2000
Unusual oxidative chemistry of N(omega)-hydroxyarginine and N-hydroxyguanidine catalyzed at an engineered cavity in a heme peroxidase. The Journal of biological chemistry, 2000, Mar-24, Volume: 275, Issue:12 Topics: Arginine; Catalytic Domain; Crystallography, X-Ray; Cytochrome-c Peroxidase; Guanidine; Guanidines; Hemeproteins; Hydrogen Peroxide; Hydroxylamines; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Protein Engineering; Recombinant Proteins; Spectrophotometry, Infrared; Substrate Specificity	2000
Decreased plasma concentrations of L-hydroxy-arginine as a marker of reduced NO formation in patients with combined cardiovascular risk factors. The Journal of laboratory and clinical medicine, 2000, Volume: 135, Issue:5 Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Citrulline; Female; Humans; Hyperglycemia; Hyperlipidemias; Hypertension; Male; Mass Spectrometry; Middle Aged; Nitric Oxide; Obesity; Risk Factors; Syndrome	2000
Arginase activity in human breast cancer cell lines: N(omega)-hydroxy-L-arginine selectively inhibits cell proliferation and induces apoptosis in MDA-MB-468 cells. Cancer research, 2000, Jun-15, Volume: 60, Issue:12 Topics: Apoptosis; Arginase; Arginine; Blotting, Western; Breast Neoplasms; Caspase 3; Caspases; Cell Cycle; Cell Division; DNA Fragmentation; Enzyme Inhibitors; Flow Cytometry; Humans; In Situ Nick-End Labeling; Nitric Oxide; Nitric Oxide Synthase; Ornithine; Reverse Transcriptase Polymerase Chain Reaction; Spermine; Tumor Cells, Cultured	2000
Low-temperature optical absorption spectra suggest a redox role for tetrahydrobiopterin in both steps of nitric oxide synthase catalysis. Biochemistry, 2000, Sep-26, Volume: 39, Issue:38 Topics: Animals; Arginine; Biopterins; Brain; Catalysis; Dithionite; Ethylene Glycol; Freezing; Isoenzymes; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen; Pterins; Rats; Reducing Agents; Spectrophotometry	2000
Electrochemical detection of nitroso-arginine as an intermediate between N-hydroxy-arginine and citrulline. An in vitro versus in vivo study using microcarbon electrodes in neuronal nitric oxide synthase and mice brain. Neuroscience letters, 2000, Nov-17, Volume: 294, Issue:2 Topics: Animals; Arginine; Brain; Brain Chemistry; Citrulline; Electrochemistry; Mice; Microelectrodes; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrites; Nitroso Compounds; Oxidation-Reduction; Surface Properties	2000
Regulation of the successive reaction catalyzed by rat neuronal nitric oxide synthase. Biochemistry, 2000, Dec-12, Volume: 39, Issue:49 Topics: Animals; Arginine; Calmodulin; Citrulline; Electron Transport; Gene Expression Regulation, Enzymologic; NADP; Nerve Tissue Proteins; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Recombinant Proteins	2000
The inhibition of arginase by N(omega)-hydroxy-l-arginine controls the growth of Leishmania inside macrophages. The Journal of experimental medicine, 2001, Mar-19, Volume: 193, Issue:6 Topics: Animals; Arginase; Arginine; Benzoates; Cells, Cultured; Enzyme Inhibitors; Imidazoles; Leishmania infantum; Leishmania major; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Ornithine; Superoxide Dismutase	2001
Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase. Biochemistry, 2001, Mar-06, Volume: 40, Issue:9 Topics: Amino Acid Substitution; Animals; Arginase; Arginine; Binding, Competitive; Catalysis; Crystallography, X-Ray; Cysteine; Enzyme Inhibitors; Histidine; Macromolecular Substances; Models, Molecular; Mutagenesis, Site-Directed; Ornithine; Rats; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity; Urea	2001
Oxidations of N(omega)-hydroxyarginine analogues and various N-hydroxyguanidines by NO synthase II: key role of tetrahydrobiopterin in the reaction mechanism and substrate selectivity. Chemical research in toxicology, 2001, Volume: 14, Issue:2 Topics: Antioxidants; Arginine; Biopterins; Guanidines; Hydroxylamines; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxidation-Reduction; Substrate Specificity; Superoxide Dismutase	2001
Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation. Proceedings of the National Academy of Sciences of the United States of America, 2001, Mar-27, Volume: 98, Issue:7 Topics: Animals; Arginine; Cell Division; Cells, Cultured; Cyclic GMP; Muscle, Smooth, Vascular; Nitric Oxide; Ornithine Decarboxylase; Polyamines; Rats	2001
Th1/Th2-regulated arginase availability modulates Leishmania infection. Trends in parasitology, 2001, Volume: 17, Issue:6 Topics: Animals; Arginase; Arginine; Humans; Interleukin-4; Leishmania major; Leishmaniasis; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Th1 Cells; Th2 Cells	2001
Mechanism of nitric oxide synthase. Evidence that direct hydrogen atom abstraction from the O-H bond of NG-hydroxyarginine is not relevant to the mechanism. Journal of the American Chemical Society, 2001, Mar-21, Volume: 123, Issue:11 Topics: Arginine; Nitric Oxide; Nitric Oxide Synthase	2001
Classical and slow-binding inhibitors of human type II arginase. Biochemistry, 2001, Aug-07, Volume: 40, Issue:31 Topics: Aminocaproates; Arginase; Arginine; Binding, Competitive; Boron; Boron Compounds; Boronic Acids; Enzyme Inhibitors; Guanidines; Humans; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Nuclear Magnetic Resonance, Biomolecular; Substrate Specificity; Time Factors	2001
X-ray absorption spectroscopic analysis of the high-spin ferriheme site in substrate-bound neuronal nitric-oxide synthase. Journal of biochemistry, 2001, Volume: 130, Issue:2 Topics: Animals; Arginine; Biopterins; Catalytic Domain; Cations, Divalent; Copper; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Heme; Humans; Ligands; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Spectrum Analysis; X-Rays	2001
Oxidation of N(omega)-hydroxyarginine analogues by NO-synthase: the simple, non amino acid N-butyl N'-hydroxyguanidine is almost as efficient an NO precursor as N(omega)-hydroxyarginine. Journal of medicinal chemistry, 2001, Sep-27, Volume: 44, Issue:20 Topics: Arginine; Guanidines; Kinetics; Nitric Oxide Donors; Nitric Oxide Synthase; Structure-Activity Relationship	2001
Activation of caspase-3 activity and apoptosis in MDA-MB-468 cells by N(omega)-hydroxy-L-arginine, an inhibitor of arginase, is not solely dependent on reduction in intracellular polyamines. Carcinogenesis, 2001, Volume: 22, Issue:11 Topics: Adenosylmethionine Decarboxylase; Apoptosis; Arginase; Arginine; Blotting, Western; Breast Neoplasms; Caspase 3; Caspases; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Activation; Enzyme Inhibitors; Humans; In Situ Nick-End Labeling; Ornithine; Ornithine Decarboxylase; Polyamines; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured	2001
L-Arginine is not the limiting factor for nitric oxide synthesis by human alveolar macrophages in vitro. The European respiratory journal, 2001, Volume: 18, Issue:4 Topics: Animals; Arginase; Arginine; Cattle; Cell Line; Fetal Blood; Guanidines; Humans; Hydrogen Peroxide; In Vitro Techniques; Macrophages; Macrophages, Alveolar; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitrites	2001
Effects of arginase isoforms on NO Production by nNOS. Nitric oxide : biology and chemistry, 2002, Volume: 6, Issue:1 Topics: Animals; Arginase; Arginine; Cell Line; Enzyme Inhibitors; Humans; Isoenzymes; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Transfection	2002
Arginase I induction in macrophages, triggered by Th2-type cytokines, supports the growth of intracellular Leishmania parasites. Parasite immunology, 2002, Volume: 24, Issue:3 Topics: Animals; Arginase; Arginine; Cytokines; Interleukin-10; Interleukin-4; Leishmania major; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ornithine; Putrescine; Th2 Cells; Transforming Growth Factor beta	2002
Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells. Circulation research, 2002, Jun-28, Volume: 90, Issue:12 Topics: Animals; Apoptosis; Arginine; Azoles; beta-Galactosidase; Cells, Cultured; Cellular Senescence; Collagen Type I; Diabetes Mellitus, Experimental; Endothelium, Vascular; Free Radical Scavengers; Glycosylation; Humans; Isoindoles; Kinetics; Metalloporphyrins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Organoselenium Compounds; Peroxynitrous Acid; Phenotype; Rats; Rats, Zucker	2002
Caspase-8-mediated BID cleavage and release of mitochondrial cytochrome c during Nomega-hydroxy-L-arginine-induced apoptosis in MDA-MB-468 cells. Antagonistic effects of L-ornithine. The Journal of biological chemistry, 2002, Oct-04, Volume: 277, Issue:40 Topics: Apoptosis; Arginine; BH3 Interacting Domain Death Agonist Protein; Breast Neoplasms; Carrier Proteins; Caspase 8; Caspase 9; Caspases; Cytochrome c Group; Female; Humans; Intracellular Membranes; Kinetics; Membrane Potentials; Mitochondria; Tumor Cells, Cultured	2002
EPR and ENDOR characterization of intermediates in the cryoreduced oxy-nitric oxide synthase heme domain with bound L-arginine or N(G)-hydroxyarginine. Biochemistry, 2002, Aug-20, Volume: 41, Issue:33 Topics: Arginine; Binding Sites; Electron Spin Resonance Spectroscopy; Freezing; Heme; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen; Protein Structure, Tertiary; Protons; Substrate Specificity	2002
Involvement of NO in the endothelium-independent relaxing effects of N(omega)-hydroxy-L-arginine and other compounds bearing a C=NOH function in the rat aorta. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:2 Topics: Animals; Aorta, Thoracic; Arginine; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indicators and Reagents; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NADPH-Ferrihemoprotein Reductase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Organic Cation Transport Proteins; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar	2002
Microperoxidase 8 catalysed nitrogen oxides formation from oxidation of N-hydroxyguanidines by hydrogen peroxide. European journal of biochemistry, 2003, Volume: 270, Issue:1 Topics: Arginine; Benzoates; Catalysis; Electron Spin Resonance Spectroscopy; Guanidines; Hydrogen Peroxide; Hydroxylamines; Imidazoles; Nitric Oxide; Oxidation-Reduction; Peroxidases; Spectrophotometry, Ultraviolet; Temperature	2003
Cyanide binding study of neuronal nitric oxide synthase: effects of inhibitors and mutations at the substrate binding site. Journal of inorganic biochemistry, 2003, May-01, Volume: 95, Issue:1 Topics: Arginine; Binding Sites; Citrulline; Cyanides; Enzyme Inhibitors; Indazoles; Mutagenesis, Site-Directed; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Spectrophotometry, Ultraviolet; Thiourea	2003
A tetrahydrobiopterin radical forms and then becomes reduced during Nomega-hydroxyarginine oxidation by nitric-oxide synthase. The Journal of biological chemistry, 2003, Nov-21, Volume: 278, Issue:47 Topics: Animals; Arginine; Biopterins; Catalysis; Cloning, Molecular; Electron Spin Resonance Spectroscopy; Free Radicals; Freezing; Kinetics; Mice; Nitric Oxide Synthase; Oxidation-Reduction; Solutions	2003
Translational control of inducible nitric oxide synthase by IL-13 and arginine availability in inflammatory macrophages. Journal of immunology (Baltimore, Md. : 1950), 2003, Nov-01, Volume: 171, Issue:9 Topics: Animals; Arginase; Arginine; Ascitic Fluid; Cell Count; Cells, Cultured; Culture Media, Conditioned; Dose-Response Relationship, Immunologic; Enzyme Inhibitors; Enzyme Stability; Female; Interleukin-13; Macrophages, Peritoneal; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Biosynthesis	2003
Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: formation of a pterin radical is required for enzyme activity. Biochemistry, 2003, Nov-18, Volume: 42, Issue:45 Topics: Amino Acids; Arginine; Binding Sites; Biopterins; Catalysis; Dithionite; Electron Spin Resonance Spectroscopy; Enzyme Activation; Free Radicals; Freezing; Heme; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxyhemoglobins; Protein Structure, Tertiary; Pterins; Recombinant Proteins; Time Factors	2003
Modulation of intrinsic cavernous tone and nitric oxide production by arginase in rabbit corpus cavernosum. The Journal of urology, 2004, Volume: 171, Issue:1 Topics: Animals; Arginine; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Penis; Rabbits	2004
Expression of nitric oxide synthase and effect of substrate manipulation of the nitric oxide pathway in mouse ovarian follicles. Human reproduction (Oxford, England), 2004, Volume: 19, Issue:1 Topics: Animals; Arginine; Citrulline; Culture Media; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Mice; Mice, Inbred Strains; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Ovarian Follicle; Ovulation; RNA, Messenger; Tissue Survival; Transferrin	2004
Distribution and properties of arginase in the salivary glands of four species of laboratory mammals. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2004, Volume: 174, Issue:3 Topics: Animals; Animals, Laboratory; Arginase; Arginine; Enzyme Inhibitors; Guinea Pigs; Kidney; Kinetics; Liver; Male; Mice; Ornithine; Physiology, Comparative; Rabbits; Rats; Rats, Sprague-Dawley; Salivary Glands; Species Specificity; Subcellular Fractions; Submandibular Gland	2004
Arginase induction promotes Trypanosoma cruzi intracellular replication in Cruzipain-treated J774 cells through the activation of multiple signaling pathways. European journal of immunology, 2004, Volume: 34, Issue:1 Topics: Animals; Arginase; Arginine; Carbazoles; Cell Division; Cyclic AMP-Dependent Protein Kinases; Cysteine Endopeptidases; Enzyme Induction; Genistein; Growth Inhibitors; Imidazoles; Indoles; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Protozoan Proteins; Pyridines; Pyrroles; Signal Transduction; Trypanosoma cruzi	2004
Nitration of a peptide phytotoxin by bacterial nitric oxide synthase. Nature, 2004, May-06, Volume: 429, Issue:6987 Topics: Arginine; Gene Deletion; Genes, Bacterial; Indoles; Molecular Sequence Data; Nitrates; Nitric Oxide Synthase; Nitrites; Nitrogen; Piperazines; Plants; Streptomyces; Toxins, Biological	2004
Quantum chemical calculations of the NHA bound nitric oxide synthase active site: O2 binding and implications for the catalytic mechanism. Journal of the American Chemical Society, 2004, Aug-25, Volume: 126, Issue:33 Topics: Arginine; Binding Sites; Catalysis; Computer Simulation; Models, Molecular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Protein Conformation; Protons; Quantum Theory; Static Electricity; Thermodynamics	2004
Regulation of plant arginase by wounding, jasmonate, and the phytotoxin coronatine. The Journal of biological chemistry, 2004, Oct-29, Volume: 279, Issue:44 Topics: Amino Acid Sequence; Amino Acids; Arginase; Arginine; Cyclopentanes; Gene Expression Regulation, Plant; Indenes; Molecular Sequence Data; Oxylipins; Phylogeny; Pseudomonas syringae; Solanum lycopersicum	2004
Implication of intercellular adhesion molecule-1 (ICAM-1) and serum N(G)-hydroxy-L-arginine (L-NHA) in the pathogenesis of systemic sclerosis. The Egyptian journal of immunology, 2003, Volume: 10, Issue:2 Topics: Adult; Aged; Arginine; Biomarkers; Case-Control Studies; Female; Humans; Intercellular Adhesion Molecule-1; Male; Middle Aged; Scleroderma, Systemic; Skin; Solubility	2003
Nomega-hydroxy-L-arginine homologues and hydroxylamine as nitric oxide-dependent vasorelaxant agents. European journal of pharmacology, 2005, Jun-15, Volume: 516, Issue:3 Topics: Animals; Aorta, Thoracic; Arginine; Cyclic GMP; Cyclic N-Oxides; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Hydroxylamine; Imidazoles; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Vasodilation; Vasodilator Agents	2005
Capillary electrophoresis of the electrochemical oxidation products of Ng-hydroxy-l-arginine at physiological pH. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, Sep-25, Volume: 824, Issue:1-2 Topics: Arginine; Electrochemistry; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Nitrosation; Oxidation-Reduction; Reproducibility of Results	2005
Nitrosyl-heme structures of Bacillus subtilis nitric oxide synthase have implications for understanding substrate oxidation. Biochemistry, 2006, Feb-28, Volume: 45, Issue:8 Topics: Arginine; Bacillus subtilis; Binding Sites; Catalysis; Crystallography, X-Ray; Ferric Compounds; Ferrous Compounds; Heme; Hemoglobins; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxidoreductases; Oxygen; Protein Structure, Tertiary; Substrate Specificity	2006
Discriminating formation of HNO from other reactive nitrogen oxide species. Free radical biology & medicine, 2006, Mar-15, Volume: 40, Issue:6 Topics: Arginine; Dimerization; Glutathione; Hydroxylamine; Nitrites; Nitrogen Dioxide; Nitrogen Oxides; Peroxynitrous Acid; Reactive Nitrogen Species	2006
Mitochondrial arginase II modulates nitric-oxide synthesis through nonfreely exchangeable L-arginine pools in human endothelial cells. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 318, Issue:3 Topics: Arginase; Arginine; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; RNA, Messenger	2006
Reduction of Nomega-hydroxy-L-arginine to L-arginine by pig liver microsomes, mitochondria, and human liver microsomes. Biochemical and biophysical research communications, 2006, Oct-20, Volume: 349, Issue:2 Topics: Animals; Arginine; Cytochrome-B(5) Reductase; Cytochromes b5; Humans; Kinetics; Liver; Microsomes, Liver; Mitochondria; Models, Chemical; Nitric Oxide Synthase; Oxygen; Swine	2006
Inducible and neuronal nitric oxide synthases (NOS) have complementary roles in recovery sleep induction. The European journal of neuroscience, 2006, Volume: 24, Issue:5 Topics: Adenosine; Animals; Arginine; Electroencephalography; Electromyography; Imines; Lactic Acid; Lipopolysaccharides; Male; Microinjections; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Pyruvic Acid; Rats; Rats, Wistar; Sleep Deprivation; Sleep Stages; Wakefulness	2006
Substrate- and isoform-specific dioxygen complexes of nitric oxide synthase. Journal of the American Chemical Society, 2007, May-30, Volume: 129, Issue:21 Topics: Arginine; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxygen; Spectrum Analysis, Raman; Substrate Specificity	2007
Diabetic urethropathy compounds the effects of diabetic cystopathy. The Journal of urology, 2007, Volume: 178, Issue:5 Topics: Adrenergic alpha-Agonists; Animals; Antibiotics, Antineoplastic; Arginine; Bungarotoxins; Diabetes Mellitus, Experimental; Electromyography; Female; Follow-Up Studies; Muscle Contraction; Phenylephrine; Rats; Rats, Sprague-Dawley; Streptozocin; Urethra; Urethral Diseases; Urinary Bladder; Urinary Bladder Diseases	2007
Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles. The Journal of physiology, 2008, Feb-15, Volume: 586, Issue:4 Topics: Aging; Animals; Arginase; Arginine; Arterioles; Biopterins; Endothelium, Vascular; Enzyme Inhibitors; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Pterins; Rats; Rats, Inbred F344; Vasodilation	2008
Synthetic approaches to N(delta)-methylated L-arginine, N(omega)-hydroxy-L-arginine, L-citrulline, and N(delta)-cyano-L-ornithine. The Journal of organic chemistry, 2008, Feb-01, Volume: 73, Issue:3 Topics: Arginine; Boron Compounds; Citrulline; Molecular Structure; Ornithine; Oxazolone	2008
Thermodynamic analysis of L-arginine and N omega-hydroxy-L-arginine binding to nitric oxide synthase. Biochimica et biophysica acta, 2008, Volume: 1784, Issue:5 Topics: Arginine; Binding Sites; Crystallography, X-Ray; Entropy; Nitric Oxide Synthase; Temperature	2008
Effect of NO-synthase and arginase inhibition in airway hyperreactivity. Bratislavske lekarske listy, 2008, Volume: 109, Issue:5 Topics: Allergens; Animals; Arginase; Arginine; Bronchial Hyperreactivity; Enzyme Inhibitors; Guanidines; Guinea Pigs; In Vitro Techniques; Lung; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Ovalbumin; Trachea	2008
The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries. British journal of pharmacology, 2009, Volume: 156, Issue:1 Topics: Acetylcholine; Animals; Aorta, Thoracic; Arginase; Arginine; Boronic Acids; Eflornithine; Endothelium, Vascular; In Vitro Techniques; Male; Mesenteric Arteries; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Tachyphylaxis; Valine; Vasodilator Agents	2009
Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death. British journal of haematology, 2009, Volume: 145, Issue:4 Topics: Anemia, Sickle Cell; Arginine; Case-Control Studies; Citrulline; Follow-Up Studies; Hemolysis; Humans; Hypertension, Pulmonary; Kidney Diseases; Linear Models; Nitric Oxide Synthase; omega-N-Methylarginine; Oxygen; Proportional Hazards Models; Risk; Survival Rate	2009
Time course of desflurane-induced preconditioning in rabbits. Journal of cardiothoracic and vascular anesthesia, 2010, Volume: 24, Issue:1 Topics: Anesthetics, Inhalation; Animals; Arginine; Desflurane; Disease Models, Animal; Ischemic Preconditioning, Myocardial; Isoflurane; Male; Myocardial Infarction; Nitric Oxide Synthase; Rabbits; Random Allocation; Time Factors	2010
EPR and ENDOR characterization of the reactive intermediates in the generation of NO by cryoreduced oxy-nitric oxide synthase from Geobacillus stearothermophilus. Journal of the American Chemical Society, 2009, Oct-14, Volume: 131, Issue:40 Topics: Arginine; Bacterial Proteins; Catalytic Domain; Citrulline; Electron Spin Resonance Spectroscopy; Ferrous Compounds; Geobacillus stearothermophilus; Heme; Models, Molecular; Nitric Oxide; Nitric Oxide Synthase; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction	2009
Single crystal structural and absorption spectral characterizations of nitric oxide synthase complexed with N(omega)-hydroxy-L-arginine and diatomic ligands. Biochemistry, 2009, Nov-03, Volume: 48, Issue:43 Topics: Animals; Arginine; Carbon Monoxide; Crystallography, X-Ray; Nitric Oxide; Nitric Oxide Synthase; Protein Binding; Rats; Spectrophotometry, Ultraviolet; X-Ray Diffraction	2009
Species differences in expression pattern of arginase isoenzymes and differential effects of arginase inhibition on collagen synthesis in human and rat pulmonary fibroblasts. Naunyn-Schmiedeberg's archives of pharmacology, 2010, Volume: 381, Issue:4 Topics: Animals; Arginase; Arginine; Collagen; Female; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Lung; Male; Proline; Rats; Rats, Sprague-Dawley; RNA, Messenger; Species Specificity; Trachea; Transforming Growth Factor beta1	2010
Comparison of wild type neuronal nitric oxide synthase and its Tyr588Phe mutant towards various L-arginine analogues. Journal of inorganic biochemistry, 2010, Volume: 104, Issue:10 Topics: Amino Acid Substitution; Arginine; Binding, Competitive; Catalysis; Catalytic Domain; Electron Spin Resonance Spectroscopy; Imidazoles; Kinetics; Models, Chemical; Models, Molecular; Molecular Structure; Mutant Proteins; Mutation; Nitric Oxide; Nitric Oxide Synthase Type I; Oxidation-Reduction; Protein Structure, Tertiary; Spectrophotometry; Substrate Specificity	2010
Reduction of N(ω)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC). The Biochemical journal, 2011, Jan-15, Volume: 433, Issue:2 Topics: Animals; Arginine; Benzamidines; Hep G2 Cells; Humans; Mitochondrial Proteins; Oxidation-Reduction; Oxidoreductases; Swine	2011
Arginase 1 contributes to diminished coronary arteriolar dilation in patients with diabetes. American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:3 Topics: Acetylcholine; Aged; Arginase; Arginine; Arterioles; Coronary Vessels; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Nitroprusside; Up-Regulation; Vasodilation; Vasodilator Agents	2011
Competition of NO synthases and arginase in the airways hyperreactivity. General physiology and biophysics, 2011, Volume: 30, Issue:1 Topics: Acetylcholine; Allergens; Animals; Arginase; Arginine; Bronchial Hyperreactivity; Enzyme Inhibitors; Guanidines; Guinea Pigs; Histamine; Lung; Male; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Ovalbumin; Substrate Specificity; Trachea	2011
Cells derived from normal or cancer breast tissue exhibit different growth properties when deprived of arginine. Medical oncology (Northwood, London, England), 2012, Volume: 29, Issue:4 Topics: Arginine; Breast; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Eflornithine; Female; Humans	2012
Electron paramagnetic resonance characterization of tetrahydrobiopterin radical formation in bacterial nitric oxide synthase compared to mammalian nitric oxide synthase. Biophysical journal, 2012, Jul-03, Volume: 103, Issue:1 Topics: Animals; Arginine; Bacillus subtilis; Bacterial Proteins; Biopterins; Electron Spin Resonance Spectroscopy; Escherichia coli; Free Radicals; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Rats; Species Specificity	2012
Oxidation of N-hydroxy-l-arginine by hypochlorous acid to form nitroxyl (HNO). Journal of inorganic biochemistry, 2013, Volume: 118 Topics: Arginine; Chromatography, Gas; Horseradish Peroxidase; Hydroxylamine; Hypochlorous Acid; Kinetics; Mass Spectrometry; Nitrogen Oxides; Oxidants; Oxidation-Reduction; Peroxidase	2013
Unusual hepatic mitochondrial arginase in an Indian air-breathing teleost, Heteropneustes fossilis: purification and characterization. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2013, Volume: 164, Issue:2 Topics: Animals; Arginase; Arginine; Biocatalysis; Blotting, Western; Catfishes; Cobalt; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Fish Proteins; Hydrogen-Ion Concentration; India; Isoelectric Focusing; Kinetics; Manganese; Mitochondria, Liver; Molecular Weight; Ornithine; Substrate Specificity; Temperature	2013
Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections. Archives of biochemistry and biophysics, 2013, Jul-15, Volume: 535, Issue:2 Topics: Aminocaproates; Animals; Antiparasitic Agents; Arginase; Arginine; Boron Compounds; Crystallography, X-Ray; Female; Humans; Leishmania mexicana; Leishmaniasis, Cutaneous; Mice; Mice, Inbred BALB C; Models, Molecular; Ornithine; Polyamines; Protein Conformation; Protein Multimerization; Protozoan Proteins	2013
Methylated N(ω)-hydroxy-L-arginine analogues as mechanistic probes for the second step of the nitric oxide synthase-catalyzed reaction. Biochemistry, 2013, May-07, Volume: 52, Issue:18 Topics: Animals; Arginine; Catalysis; Chromatography, High Pressure Liquid; Citrulline; Crystallography, X-Ray; Kinetics; Mass Spectrometry; Methylation; Models, Molecular; Molecular Probes; NADP; Nitric Oxide; Nitric Oxide Synthase Type I; Rats; Substrate Specificity	2013
Proteomic identification of mitochondrial targets of arginase in human breast cancer. PloS one, 2013, Volume: 8, Issue:11 Topics: Animals; Apoptosis; Arginase; Arginine; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Electrophoresis, Gel, Two-Dimensional; Female; Glycine Hydroxymethyltransferase; Humans; Mass Spectrometry; Mice; Mice, Nude; Middle Aged; Mitochondria; Mitochondrial Proteins; Proteomics; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transplantation, Heterologous; Tumor Burden	2013
Airway arginase expression and Nω-hydroxy-nor-arginine effect on methacholine-induced bronchoconstriction differentiate Lewis and Fischer rat strains. Journal of applied physiology (Bethesda, Md. : 1985), 2014, Mar-15, Volume: 116, Issue:6 Topics: Animals; Arginase; Arginine; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Lung; Male; Methacholine Chloride; Myocytes, Smooth Muscle; Rats; Rats, Inbred F344; Rats, Inbred Lew; RNA, Messenger; Species Specificity	2014
Enzymatic and cryoreduction EPR studies of the hydroxylation of methylated N(ω)-hydroxy-L-arginine analogues by nitric oxide synthase from Geobacillus stearothermophilus. Biochemistry, 2014, Oct-21, Volume: 53, Issue:41 Topics: Animals; Arginine; Bacterial Proteins; Biocatalysis; Citrulline; Cold Temperature; Electron Spin Resonance Spectroscopy; Geobacillus stearothermophilus; Hydrogen Peroxide; Hydroxylation; Isomerism; Kinetics; Methylation; Mice; Models, Molecular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Protein Stability; Recombinant Proteins; Substrate Specificity	2014
NMDA-NO signaling in the dorsal and ventral hippocampus time-dependently modulates the behavioral responses to forced swimming stress. Behavioural brain research, 2016, 07-01, Volume: 307 Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Cobalt; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Exploratory Behavior; Hippocampus; Male; Nitric Oxide; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Swimming	2016
Design, Synthesis, and Bioactivation of O-Glycosylated Prodrugs of the Natural Nitric Oxide Precursor N(ω)-Hydroxy-l-arginine. Journal of medicinal chemistry, 2016, 09-08, Volume: 59, Issue:17 Topics: Animals; Arginine; Cell Line; Drug Design; Galactose; Glucose; Glycosylation; Macrophages; Mice; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Prodrugs; Stereoisomerism; Structure-Activity Relationship	2016
Revisiting the Val/Ile Mutation in Mammalian and Bacterial Nitric Oxide Synthases: A Spectroscopic and Kinetic Study. Biochemistry, 2017, 02-07, Volume: 56, Issue:5 Topics: Amino Acid Substitution; Animals; Arginine; Bacillus subtilis; Bacterial Proteins; Biocatalysis; Biopterins; Catalytic Domain; Coenzymes; Conserved Sequence; Escherichia coli; Gene Expression; Hydrogen Bonding; Isoleucine; Kinetics; Mice; Mutation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Recombinant Proteins; Species Specificity; Valine	2017
Theoretical studies of the second step of the nitric oxide synthase reaction: Electron tunneling prevents uncoupling. Journal of inorganic biochemistry, 2018, Volume: 181 Topics: Animals; Arginine; Biocatalysis; Biopterins; Catalytic Domain; Citrulline; Conserved Sequence; Databases, Protein; Electron Transport; Humans; Hydrogen Bonding; Models, Molecular; NADP; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidation-Reduction; Protons; Quantum Theory; Thermodynamics	2018
Investigation of N Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018, Nov-15, Volume: 1100-1101 Topics: Arginine; Gas Chromatography-Mass Spectrometry; Humans; Nitrates; Nitrites	2018
Pharmacological activation of dimethylarginine dimethylaminohydrolase (DDAH) activity by inorganic nitrate and DDAH inhibition by N Amino acids, 2019, Volume: 51, Issue:3 Topics: Amidohydrolases; Animals; Arginine; Citrulline; Liver; Nitrates; Rats; Recombinant Proteins	2019
Thin-layer chromatography-bioautographic method for the detection of arginase inhibitors. Journal of separation science, 2020, Volume: 43, Issue:12 Topics: Arginase; Arginine; Automation, Laboratory; Cannabis; Chromatography, Thin Layer; Enzyme Inhibitors; Fruit; Myrtus; Plant Extracts	2020
Crystal structure of an N Acta crystallographica. Section D, Structural biology, 2020, Jun-01, Volume: 76, Issue:Pt 6 Topics: Amidohydrolases; Arginine; Bacterial Proteins; Cycloserine; Protein Structure, Tertiary; Streptomyces; Substrate Specificity	2020