Page last updated: 2024-09-02

n(g)-iminoethylornithine and nitroarginine

n(g)-iminoethylornithine has been researched along with nitroarginine in 27 studies

Compound Research Comparison

Studies
(n(g)-iminoethylornithine)
Trials
(n(g)-iminoethylornithine)
Recent Studies (post-2010)
(n(g)-iminoethylornithine)
Studies
(nitroarginine)
Trials
(nitroarginine)
Recent Studies (post-2010) (nitroarginine)
1711363,93511175

Protein Interaction Comparison

ProteinTaxonomyn(g)-iminoethylornithine (IC50)nitroarginine (IC50)
Nitric oxide synthase, endothelialBos taurus (cattle)1.2
Nitric oxide synthase, endothelialHomo sapiens (human)0.38
Nitric oxide synthase, brainHomo sapiens (human)1.265
Nitric oxide synthase, brain Rattus norvegicus (Norway rat)4.12
Nitric oxide synthase, inducibleMus musculus (house mouse)0.5
Nitric oxide synthase, inducibleHomo sapiens (human)6.2
Nitric oxide synthase, brainMus musculus (house mouse)0.5

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's21 (77.78)18.2507
2000's3 (11.11)29.6817
2010's3 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Currie, MG; Jerome, GM; Misko, TP; Moore, WM; Tjoeng, FS; Webber, RK1
Huang, H; Martasek, P; Masters, BS; Roman, LJ; Silverman, RB1
Campillo, NE; Castaño, T; Castro, A; Encinas, A; Gil, C; Pérez, C1
Beitz, E; Clement, B; Kotthaus, J; Muschick, N; Schade, D1
Clement, B; Kotthaus, J; Schade, D1
Moncada, S; Mulligan, MS; Ward, PA1
Bogle, RG; Mann, GE; Moncada, S; Pearson, JD1
Knowles, RG; Moncada, S; Palacios, M; Palmer, RM1
Giles, TD; Greenberg, SS; Grisham, MB; Lancaster, J; Powers, DR; Spitzer, JJ; Wang, JF; Xie, J1
Baydoun, AR; Mann, GE1
Basha, F; Carter, GW; Esumi, H; Hokari, A; Klinghofer, V; Marsden, PA; Nakane, M; Ogura, T; Pollock, JS1
Duffy, C; Hazelwood, R; Salter, M1
Hangai, M; Iwaki, M; Kogishi, J; Mandai, M; Mittag, TW; Yoshimura, N1
Carbonell, T; Mitjavila, MT; Ródenas, J1
Dunn, D; Farnworth, M; Gyte, A; Lock, EA; Moore, RB; Simpson, MG; Widdowson, PS; Wyatt, I1
Kimes, AS; London, ED; Vaupel, DB1
Masters, BS; McMillan, K; Salerno, JC1
García-Cardeña, G; Nathan, CF; Sessa, WC; Smith, SD; Weiss, RM; Wheeler, MA1
González-Macías, J; Riancho, JA; Salas, E; Zarrabeitia, MT1
Champion, HC; DeWitt, BJ; Giles, TD; Greenberg, SS; Kadowitz, PJ; Marrone, JR; McNamara, DB1
Dick, JM; Lefebvre, RA1
Clarkson, RB; Cruz, L; Gillette, R; Moroz, LL; Norby, SW; Sweedler, JV1
Higuchi, T; Hirobe, M; Kikuchi, K; Kobayashi, N; Nagano, T; Urano, Y1
Russell, RJ1
Ahmad, S; Ahmed, A; Ahmed, S; Al-Ani, B; Cudmore, M; Fujisawa, T; Hewett, PW1
Choe, J; Ha, KS; Jeoung, D; Kim, YM; Kwon, YG; Lee, DK; Lee, H; Lee, KS; Won, MH1
Almeida, R; Duarte, ID; Fontes, MA; Galdino, GS; Menezes, G; Perez, AC; Silva, G; Xavier, CH1

Reviews

1 review(s) available for n(g)-iminoethylornithine and nitroarginine

ArticleYear
Nitric oxide synthase inhibitors. Preclinical studies of potential use for treatment of opioid withdrawal.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1995, Volume: 13, Issue:4

    Topics: Adrenergic alpha-Agonists; Animals; Arginine; Blood Pressure; Clonidine; Depression, Chemical; Enzyme Inhibitors; Heart Rate; Indazoles; Morphine; Narcotics; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Opioid-Related Disorders; Ornithine; Substance Withdrawal Syndrome

1995

Other Studies

26 other study(ies) available for n(g)-iminoethylornithine and nitroarginine

ArticleYear
L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase.
    Journal of medicinal chemistry, 1994, Nov-11, Volume: 37, Issue:23

    Topics: Amino Acid Oxidoreductases; Animals; Brain; Lysine; Mice; Nitric Oxide Synthase; Rats

1994
N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase.
    Journal of medicinal chemistry, 1999, Aug-12, Volume: 42, Issue:16

    Topics: Animals; Cattle; Dipeptides; Enzyme Inhibitors; Mice; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroarginine; Rats

1999
Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Drug Design; Enzyme Inhibitors; Isoenzymes; Neural Networks, Computer; Nitric Oxide Synthase Type I; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Thiadiazoles; Thiourea

2008
Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads.
    Bioorganic & medicinal chemistry, 2008, Dec-15, Volume: 16, Issue:24

    Topics: Amidines; Amidohydrolases; Arginine; Humans; Inhibitory Concentration 50; Kinetics; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Structure-Activity Relationship

2008
Designing modulators of dimethylarginine dimethylaminohydrolase (DDAH): a focus on selectivity over arginase.
    Journal of enzyme inhibition and medicinal chemistry, 2012, Volume: 27, Issue:1

    Topics: Amidohydrolases; Arginine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Molecular Structure; Ornithine; Stereoisomerism; Structure-Activity Relationship

2012
Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis.
    British journal of pharmacology, 1992, Volume: 107, Issue:4

    Topics: Alveolitis, Extrinsic Allergic; Amino Acid Oxidoreductases; Animals; Arginine; Immune Complex Diseases; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Ornithine; Peroxidase; Rats; Vasculitis, Leukocytoclastic, Cutaneous

1992
Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell L-arginine transporter.
    British journal of pharmacology, 1992, Volume: 105, Issue:4

    Topics: Amino Acid Oxidoreductases; Amino Acid Transport Systems; Animals; Arginine; Biological Transport, Active; Carrier Proteins; Cells, Cultured; Endothelium, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Ornithine

1992
Kinetic characteristics of nitric oxide synthase from rat brain.
    The Biochemical journal, 1990, Jul-01, Volume: 269, Issue:1

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Binding, Competitive; Brain; Diencephalon; Guanylate Cyclase; Kinetics; Male; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Ornithine; Rats; Synaptosomes; Telencephalon; Tissue Distribution

1990
Nitro containing L-arginine analogs interfere with assays for nitrate and nitrite.
    Life sciences, 1995, Volume: 57, Issue:21

    Topics: Animals; Arginine; Enzyme Inhibitors; Evaluation Studies as Topic; Guanidines; Luminescent Measurements; Macrophages, Alveolar; Male; Mice; Mice, Inbred BALB C; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitrites; Nitroarginine; Ornithine; Rats; Rats, Sprague-Dawley; Triazines

1995
Selective targeting of nitric oxide synthase inhibitors to system y+ in activated macrophages.
    Biochemical and biophysical research communications, 1994, Apr-29, Volume: 200, Issue:2

    Topics: Amino Acid Oxidoreductases; Amino Acid Transport Systems; Animals; Arginine; Biological Transport, Active; Canavanine; Carrier Proteins; Cell Line; Citrulline; Lipopolysaccharides; Macrophage Activation; Macrophages; Membrane Glycoproteins; Membrane Proteins; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Ornithine; Receptors, Virus

1994
Functional expression of three isoforms of human nitric oxide synthase in baculovirus-infected insect cells.
    Biochemical and biophysical research communications, 1995, Jan-17, Volume: 206, Issue:2

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Baculoviridae; Blotting, Western; Cell Line; Chromatography, Affinity; DNA, Complementary; Endothelium, Vascular; Enzyme Induction; Gene Expression; Guanidines; Humans; Isoenzymes; Kinetics; Mice; Neurons; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Ornithine; Recombinant Proteins; Spodoptera; Transfection

1995
Determination of brain nitric oxide synthase inhibition in vivo: ex vivo assays of nitric oxide synthase can give incorrect results.
    Neuropharmacology, 1995, Volume: 34, Issue:3

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Brain; Cerebellum; Cyclic GMP; Harmaline; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Ornithine; Rats; Rats, Wistar

1995
Role of nitric oxide synthase isozymes in endotoxin-induced uveitis.
    Investigative ophthalmology & visual science, 1996, Volume: 37, Issue:5

    Topics: Animals; Aqueous Humor; Arginine; Cell Count; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Isoenzymes; Lipopolysaccharides; Male; Nitric Oxide Synthase; Nitroarginine; Ornithine; Phagocytes; Rats; Rats, Inbred Lew; Salmonella; Uveitis, Anterior

1996
Conditions to study nitric oxide generation by polymorphonuclear cells from an inflammatory exudate in rats.
    Archives of biochemistry and biophysics, 1996, Mar-15, Volume: 327, Issue:2

    Topics: Animals; Arginine; Carrageenan; Enzyme Inhibitors; Exudates and Transudates; Inflammation; Kinetics; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Ornithine; Rats; Superoxides; Tetradecanoylphorbol Acetate; Zymosan

1996
Possible role of nitric oxide in the development of L-2-chloropropionic acid-induced cerebellar granule cell necrosis.
    British journal of pharmacology, 1996, Volume: 117, Issue:8

    Topics: Animals; Aspartic Acid; Cerebellum; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hydrocarbons, Chlorinated; In Vitro Techniques; Indazoles; Male; Necrosis; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Ornithine; Propionates; Rats

1996
Binding of intermediate, product, and substrate analogs to neuronal nitric oxide synthase: ferriheme is sensitive to ligand-specific effects in the L-arginine binding site.
    Biochemistry, 1996, Sep-10, Volume: 35, Issue:36

    Topics: Animals; Arginine; Binding Sites; Cell Line; Citrulline; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Heme; Kidney; Neurons; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Ornithine; Rats

1996
Bacterial infection induces nitric oxide synthase in human neutrophils.
    The Journal of clinical investigation, 1997, Jan-01, Volume: 99, Issue:1

    Topics: Adult; Aged; Anti-Bacterial Agents; Arginine; Bacterial Infections; Blotting, Western; Canavanine; Cell Membrane; Citrulline; Female; Guanidines; Humans; Immunohistochemistry; Isoenzymes; Leukocyte Common Antigens; Male; Middle Aged; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Ornithine; Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Thiourea; Trifluoperazine; Urinary Tract Infections

1997
Impairment of osteoblast growth by nitric oxide synthase inhibitors: an effect independent of nitric oxide and arginine transport inhibition.
    Methods and findings in experimental and clinical pharmacology, 1996, Volume: 18, Issue:10

    Topics: Animals; Arginine; Cell Division; Cells, Cultured; Humans; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Ornithine; Osteoblasts; Rats

1996
Differential effects of L-N5-(1-iminoethyl)-ornithine on tone and endothelium-dependent vasodilator responses.
    The American journal of physiology, 1997, Volume: 273, Issue:3 Pt 1

    Topics: Acetylcholine; Adenosine; Adrenomedullin; Animals; Arginine; Blood Pressure; Bradykinin; Cats; Endothelium, Vascular; Female; Guanidines; Male; Muscle Tonus; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Ornithine; Peptides; Pinacidil; Pulmonary Artery; Pulmonary Circulation; Substance P; Vasodilation; Vasodilator Agents

1997
Influence of different classes of NO synthase inhibitors in the pig gastric fundus.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:4

    Topics: Animals; Biotin; Citrulline; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; In Vitro Techniques; Isothiuronium; Lysine; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Ornithine; Swine; Thiourea

1997
Non-enzymatic production of nitric oxide (NO) from NO synthase inhibitors.
    Biochemical and biophysical research communications, 1998, Dec-30, Volume: 253, Issue:3

    Topics: Animals; Arginine; Mollusca; Nerve Tissue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Ornithine

1998
Dipeptides containing L-arginine analogs: new isozyme-selective inhibitors of nitric oxide synthase.
    Biological & pharmaceutical bulletin, 1999, Volume: 22, Issue:9

    Topics: Animals; Arginine; Dipeptides; Enzyme Inhibitors; Isoenzymes; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroarginine; Ornithine; Rats

1999
Use of arginine analogs as inhibitors of nitric oxide synthase in rat-aortic rings.
    Methods in molecular biology (Clifton, N.J.), 1998, Volume: 100

    Topics: Animals; Aorta, Thoracic; Arginine; Enzyme Inhibitors; Guanidines; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroarginine; omega-N-Methylarginine; Ornithine; Phenylephrine; Rats; Rats, Wistar

1998
The release of nitric oxide from S-nitrosothiols promotes angiogenesis.
    PloS one, 2006, Dec-20, Volume: 1

    Topics: Animals; Ascorbic Acid; Carbazoles; Cells, Cultured; Culture Media, Serum-Free; Cyclic GMP-Dependent Protein Kinases; Dithiothreitol; Endothelial Cells; Enzyme Inhibitors; Guanylate Cyclase; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroarginine; Ornithine; Oxadiazoles; Phosphorylation; Quinoxalines; S-Nitrosothiols; Swine

2006
Differential effects of substrate-analogue inhibitors on nitric oxide synthase dimerization.
    Biochemical and biophysical research communications, 2012, Feb-03, Volume: 418, Issue:1

    Topics: Animals; Cell Line; Enzyme Inhibitors; Guanidines; Lysine; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroarginine; omega-N-Methylarginine; Ornithine; Protein Multimerization; Substrate Specificity

2012
The Nitric oxide/CGMP/KATP pathway mediates systemic and central antinociception induced by resistance exercise in rats.
    The International journal of neuroscience, 2015, Volume: 125, Issue:10

    Topics: Animals; Arginine; Cyclic GMP; Enzyme Inhibitors; Glyburide; Guanidines; Guanylate Cyclase; KATP Channels; Male; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitroarginine; Nociception; Ornithine; Oxadiazoles; Pain Measurement; Physical Conditioning, Animal; Quinoxalines; Rats; Signal Transduction

2015