Compounds > n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide

n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide and piperidines

n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide has been researched along with piperidines in 51 studies

Research

Studies (51)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (29.41)	18.7374
1990's	29 (56.86)	18.2507
2000's	6 (11.76)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (1.96)	2.80

Authors

Authors	Studies
Bode, W; Brandstetter, H; Edwards, BF; Grosse, D; Hoeffken, HW; Martin, PD; Stürzebecher, J; Turk, D	1
Stocker, K	1
Pankonin, G; Teuscher, E	1
Banner, DW; Hadváry, P	2
Ajisaka, K; Nakagomi, K; Yokota, I	1
Bode, W; Stürzebecher, J; Turk, D	1
Bode, AP; Miller, DT	1
Hauptmann, J; Kaiser, B; Markwardt, F; Paintz, M	2
Hauptmann, J; Kaiser, B; Paintz, M; Richter, M	1
Brüggener, E; Hauptmann, J; Markwardt, F	1
Hauptmann, J; Paintz, M; Richter, M	1
Bernat, A; Boneu, B; Cadroy, Y; Caranobe, C; Maffrand, JP; Sié, P	1
Kaiser, B; Markwardt, F	2
Harms, C; Melzig, M; Teuscher, E; Voigt, B; Wagner, G	1
Hauptmann, J; Kaiser, B; Markwardt, F	1
Hauptmann, J; Kaiser, B; Markwardt, F; Weiss, A	1
Brogli, M; Lindeberg, G; Stocker, K; Svendsen, L	1
Hoffmann, J; Markwardt, F; Nowak, G	1
de Nanteuil, G; Laubie, M; Mennecier, P; Rupin, A; Verbeuren, TJ	1
Egner, U; Hoyer, GA; Schleuning, WD	1
De Cristofaro, R; Landolfi, R	1
Claeson, G; DeSoyza, T; Metternich, R; Niua, LH; Philipp, M	1
Claeson, G; Ehrhardt, C; Metternich, R; Scully, MF; Stone, SR; Tapparelli, C; Zurini, M	1
Bauer, M; Bergner, A; Bode, W; Brandstetter, H; Stürzebecher, J	1
Czech, J; Dickneite, G; Hoffmann, D; Koschinsky, R; Reers, M; Stüber, W	1
Böhm, HJ; Höffken, HW; Hornberger, W; Mack, H; Pfeiffer, T	1
Prasa, D; Stürzebecher, J; Vieweg, H; Wikström, P	1
Grootenhuis, PD; Karplus, M	1
Clark, DE; Murray, CW; Westhead, DR	1
Hauptmann, J; Prasa, D; Stürzebecher, J; Vieweg, H; Wikström, P	1
Prasa, D; Stürzebecher, J; Svendsen, L	1
Naylor-Olsen, AM; Sanderson, PE	1
Baxter, CA; Clark, DE; Eldridge, MD; Murray, CW; Westhead, DR	1
Deinum, J; Nilsson, T; Sjöling-Ericksson, A	1
Jenneboer, AJ; Lucas, H; Noach, AB; Rewinkel, JB; Rood, AM; van Boeckel, CA; van Dinther, TG; van Galen, PJ	1
Kramer, B; Lengauer, T; Rarey, M	1
Johnson, ME; Li, M; Lin, Z	1
Basten, JE; Buijsman, RC; van Boeckel, CA; van Boom, JH; van der Marel, GA; van Dinther, TG	1
Hoffmann, D; Kramer, B; Lengauer, T; Rarey, M; Steinmetzer, T; Washio, T	1
Caflisch, A; Majeux, N; Scarsi, M	1
Friedmann, I; Schwartz, M; Yoles, E	1
Ewing, TJ; Kuntz, ID; Makino, S; Skillman, AG	1
Hauptmann, J; Künzel, S; Schweinitz, A; Steinmetzer, T; Stürzebecher, J; Wikström, P	2
Cano, J; Carreño-Müller, E; de Pablos, RM; Herrera, AJ; Machado, A; Tomás-Camardiel, M; Venero, JL	1
HAAN, D	1
Manallack, DT	1
Chapman, J; Gera, O; Gerasimov, A; Gofrit, SG; Golderman, V; Laks, D; Maggio, N; Shavit-Stein, E	1

Reviews

3 review(s) available for n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide and piperidines

Article	Year
Laboratory use of hirudin. Seminars in thrombosis and hemostasis, 1991, Volume: 17, Issue:2 Topics: Amino Acid Sequence; Animals; Aprotinin; Blood Coagulation Tests; Blood Platelets; Blood Sedimentation; Chromogenic Compounds; Dipeptides; Enzyme Precursors; Hirudins; Leukocytes; Molecular Sequence Data; Piperidines; Rabbits; Thrombin	1991
Inhibitor binding to thrombin: x-ray crystallographic studies. Advances in experimental medicine and biology, 1993, Volume: 340 Topics: Amino Acid Sequence; Antithrombins; Arginine; Binding Sites; Crystallography, X-Ray; Dipeptides; Hirudins; Molecular Sequence Data; Molecular Structure; Pipecolic Acids; Piperidines; Sulfonamides; Thrombin	1993
Thrombin inhibitor design. Current medicinal chemistry, 1998, Volume: 5, Issue:4 Topics: Anticoagulants; Antithrombins; Arginine; Binding Sites; Dipeptides; Drug Design; Humans; Models, Molecular; Oligopeptides; Pipecolic Acids; Piperidines; Platelet Aggregation Inhibitors; Structure-Activity Relationship; Sulfonamides; Thrombin	1998

Other Studies

48 other study(ies) available for n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide and piperidines

Article	Year
Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics. Journal of molecular biology, 1992, Aug-20, Volume: 226, Issue:4 Topics: Amidines; Amino Acid Sequence; Animals; Antithrombins; Arginine; Benzamidines; Binding Sites; Cattle; Crystallography; Dipeptides; Fibrinolytic Agents; Hydrogen Bonding; Ligands; Models, Molecular; Molecular Sequence Data; Pipecolic Acids; Piperidines; Protein Conformation; Structure-Activity Relationship; Sulfonamides; Thrombin	1992
Stimulation of endothelial cell migration by thrombin. Biomedica biochimica acta, 1991, Volume: 50, Issue:9 Topics: Animals; Aorta; Cell Movement; Cells, Cultured; Dipeptides; Endothelium, Vascular; Indomethacin; Piperidines; Swine; Thrombin	1991
Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. The Journal of biological chemistry, 1991, Oct-25, Volume: 266, Issue:30 Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Arginine; Benzamidines; Binding Sites; Dipeptides; Humans; Models, Molecular; Pipecolic Acids; Piperidines; Stereoisomerism; Sulfonamides; Thrombin; Trypsin	1991
Effects of acetylthrombin on protein C activation and fibrinogen clotting. Thrombosis research, 1990, Aug-15, Volume: 59, Issue:4 Topics: Amides; Amino Acid Sequence; Animals; Antithrombin III; Antithrombins; Blood Coagulation; Dipeptides; Fibrinogen; Hirudins; Male; Molecular Sequence Data; Partial Thromboplastin Time; Phenylalanine; Piperidines; Protein C; Rabbits; Receptors, Cell Surface; Receptors, Thrombin; Serine Endopeptidases; Serine Proteinase Inhibitors; Substrate Specificity; Thrombin	1990
Geometry of binding of the benzamidine- and arginine-based inhibitors N alpha-(2-naphthyl-sulphonyl-glycyl)-DL-p-amidinophenylalanyl-pipe ridine (NAPAP) and (2R,4R)-4-methyl-1-[N alpha-(3-methyl-1,2,3,4-tetrahydro-8- quinolinesulphonyl)-L-arginyl]-2-piper European journal of biochemistry, 1990, Oct-05, Volume: 193, Issue:1 Topics: Animals; Antithrombins; Arginine; Binding Sites; Cattle; Computer Graphics; Crystallography; Dipeptides; Humans; In Vitro Techniques; Models, Molecular; Models, Structural; Molecular Conformation; Pipecolic Acids; Piperidines; Protein Binding; Structure-Activity Relationship; Sulfonamides; Thrombin; Trypsin; Trypsin Inhibitors; X-Ray Diffraction	1990
Metabolic status of platelet concentrates during extended storage: improvement with pharmacological inhibitors and reduced surface-to-volume ratio. Vox sanguinis, 1989, Volume: 57, Issue:1 Topics: Alprostadil; Aprotinin; Blood Platelets; Blood Preservation; Dipeptides; Evaluation Studies as Topic; Humans; Piperidines; Theophylline; Time Factors	1989
Pharmacological characterization of a new structural variant of 4-amidinophenylalanine amide-type synthetic thrombin inhibitor. Die Pharmazie, 1989, Volume: 44, Issue:4 Topics: Animals; Anticoagulants; Bile; Dipeptides; In Vitro Techniques; Mice; Piperidines; Rabbits; Thrombin; Thrombin Time	1989
Reduction of a benzamidoxime derivative to the corresponding benzamidine in vivo and in vitro. Die Pharmazie, 1988, Volume: 43, Issue:8 Topics: Animals; Bile; Biotransformation; Chromatography, High Pressure Liquid; Dipeptides; In Vitro Techniques; Infusions, Intravenous; Liver; Oxidation-Reduction; Phenylalanine; Piperidines; Portal Vein; Rabbits; Rats; Thrombin	1988
Effect of heparin, hirudin, and a synthetic thrombin inhibitor on antithrombin III in thrombin-induced disseminated intravascular coagulation in rats. Haemostasis, 1987, Volume: 17, Issue:6 Topics: Animals; Antithrombin III; Dipeptides; Disseminated Intravascular Coagulation; Female; Fibrinogen; Heparin; Hirudins; Male; Piperidines; Platelet Count; Rats; Rats, Inbred Strains; Thrombin	1987
HPLC Determination of the synthetic thrombin inhibitor N alpha-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide in biological material. Die Pharmazie, 1987, Volume: 42, Issue:5 Topics: Animals; Antithrombins; Bile; Chromatography, High Pressure Liquid; Dipeptides; Liver; Piperidines; Rats	1987
Antithrombotic and bleeding effects of a new synthetic direct thrombin inhibitor and of standard heparin in the rabbit. Thrombosis and haemostasis, 1987, Aug-04, Volume: 58, Issue:2 Topics: Animals; Antithrombins; Dipeptides; Drug Evaluation, Preclinical; Hemorrhage; Heparin; In Vitro Techniques; Infusions, Intravenous; Injections, Subcutaneous; Partial Thromboplastin Time; Piperidines; Rabbits; Thrombin Time; Thrombosis	1987
Biliary excretion of synthetic benzamidine-type thrombin inhibitors in rabbits and rats. Biomedica biochimica acta, 1987, Volume: 46, Issue:6 Topics: Amidines; Animals; Benzamidines; Bile; Biological Assay; Chromatography, High Pressure Liquid; Dipeptides; Female; Infusions, Intravenous; Injections, Intravenous; Injections, Subcutaneous; Male; Piperidines; Rabbits; Rats; Rats, Inbred Strains; Thrombin	1987
Antithrombotic and haemorrhagic effects of synthetic and naturally occurring thrombin inhibitors. Thrombosis research, 1986, Sep-15, Volume: 43, Issue:6 Topics: Animals; Bleeding Time; Blood Coagulation; Dipeptides; Dose-Response Relationship, Drug; Hemostasis; Heparin; Hirudins; Infusions, Intravenous; Mice; Mice, Inbred Strains; Piperidines; Rats; Rats, Inbred Strains; Thrombin; Thrombosis	1986
Influence of inhibitors of thrombin on porcine aortic smooth muscle cells in primary culture. Biomedica biochimica acta, 1986, Volume: 45, Issue:9 Topics: Animals; Antithrombins; Aorta; Cell Division; Cells, Cultured; Dipeptides; Heparin; Muscle, Smooth, Vascular; Phenylpyruvic Acids; Piperidines; Swine	1986
Experimental studies on the antithrombotic action of a highly effective synthetic thrombin inhibitor. Thrombosis and haemostasis, 1986, Apr-30, Volume: 55, Issue:2 Topics: Animals; Antithrombins; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Injections, Intravenous; Male; Piperidines; Rats; Rats, Inbred Strains; Thrombosis	1986
Anticoagulant action of synthetic tight binding inhibitors of thrombin in vitro and in vivo. Thrombosis research, 1985, Sep-15, Volume: 39, Issue:6 Topics: Animals; Anticoagulants; Binding, Competitive; Blood Coagulation; Blood Coagulation Tests; Dipeptides; Female; In Vitro Techniques; Male; Piperidines; Rabbits; Rats; Rats, Inbred Strains; Thrombin	1985
Pharmacological characterization of a new highly effective synthetic thrombin inhibitor. Biomedica biochimica acta, 1985, Volume: 44, Issue:7-8 Topics: Animals; Blood Coagulation Disorders; Dipeptides; Hypotension; Kinetics; Lethal Dose 50; Liver; Mice; Piperidines; Rabbits; Rats; Rats, Inbred Strains; Thrombin; Thrombosis	1985
Differentiation of thrombin- and factor Xa-related amidolytic activity in plasma by means of a synthetic thrombin inhibitor. Thrombosis research, 1984, Jun-01, Volume: 34, Issue:5 Topics: Aniline Compounds; Chromogenic Compounds; Dipeptides; Enzyme Activation; Enzyme Precursors; Factor X; Factor Xa; Humans; Kinetics; Piperidines; Plasma; Protease Inhibitors; Serine Endopeptidases; Thrombin; Thromboplastin	1984
Comparative studies on thrombin inhibitors in experimental microthrombosis. Thrombosis and haemostasis, 1983, Jun-28, Volume: 49, Issue:3 Topics: 4-Aminobenzoic Acid; Animals; Arginine; Dipeptides; Female; Fibrinogen; Hirudins; Kinetics; Lung; Male; Microcirculation; para-Aminobenzoates; Piperidines; Rats; Rats, Inbred Strains; Thrombin; Thrombosis	1983
A screening procedure to evaluate the anticoagulant activity and the kinetic behaviour of direct thrombin inhibitors. Thrombosis research, 1995, May-01, Volume: 78, Issue:3 Topics: Amino Acid Sequence; Anticoagulants; Antithrombins; Binding Sites; Blood Coagulation Tests; Boron Compounds; Dipeptides; Drug Evaluation, Preclinical; Fibrin; Fibrinogen; Hirudins; Humans; Kinetics; Microchemistry; Molecular Sequence Data; Oligopeptides; Peptide Fragments; Piperidines; Protein Structure, Tertiary; Recombinant Proteins; Thrombin	1995
Rational design of hirulog-type inhibitors of thrombin. Journal of computer-aided molecular design, 1994, Volume: 8, Issue:5 Topics: Amino Acid Sequence; Binding Sites; Computer-Aided Design; Dipeptides; Drug Design; Hirudins; Humans; Hydrogen Bonding; In Vitro Techniques; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutation; Peptide Fragments; Piperidines; Protein Conformation; Recombinant Proteins; Stereoisomerism; Thermodynamics; Thrombin	1994
Thermodynamics of substrates and reversible inhibitors binding to the active site cleft of human alpha-thrombin. Journal of molecular biology, 1994, Jun-17, Volume: 239, Issue:4 Topics: Amino Acid Sequence; Antithrombins; Benzamidines; Binding Sites; Dipeptides; Humans; Kinetics; Molecular Sequence Data; Oligopeptides; Piperidines; Proflavine; Temperature; Thermodynamics; Thrombin; Trypsin Inhibitors; Viscosity	1994
pH-dependent binding constants for the inhibition of thrombin by transition state analogs. Advances in experimental medicine and biology, 1993, Volume: 340 Topics: Amino Acid Sequence; Animals; Antithrombins; Arsenicals; Boronic Acids; Carboxylic Acids; Cattle; Dipeptides; Hydrogen-Ion Concentration; Kinetics; Leupeptins; Molecular Sequence Data; Peptides; Piperidines; Thrombin	1993
In vitro and in vivo characterization of a neutral boron-containing thrombin inhibitor. The Journal of biological chemistry, 1993, Mar-05, Volume: 268, Issue:7 Topics: Animals; Antithrombins; Arginine; Blood Coagulation Tests; Boron; Bridged Bicyclo Compounds; Cells, Cultured; Dipeptides; Hirudins; Humans; Kinetics; Male; Oligopeptides; Pipecolic Acids; Piperidines; Platelet Activation; Platelet Aggregation; Rats; Rats, Wistar; Sulfonamides; Thrombin	1993
The X-ray crystal structure of thrombin in complex with N alpha-2-naphthylsulfonyl-L-3-amidino-phenylalanyl-4-methylpiperidide: the beneficial effect of filling out an empty cavity. Journal of enzyme inhibition, 1995, Volume: 9, Issue:1 Topics: Alanine; Antithrombins; Binding Sites; Computer Graphics; Crystallography, X-Ray; Dipeptides; Models, Molecular; Piperidines; Protein Binding; Serine Proteinase Inhibitors; Thrombin	1995
Synthesis and characterisation of novel thrombin inhibitors based on 4-amidinophenylalanine. Journal of enzyme inhibition, 1995, Volume: 9, Issue:1 Topics: Antithrombins; Binding Sites; Blood Coagulation; Dipeptides; Drug Design; Factor Xa Inhibitors; Fibrinolysin; Humans; Intestinal Mucosa; Kinetics; Molecular Structure; Piperidines; Platelet Aggregation; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thrombin; Trypsin	1995
Design, synthesis and biological activity of novel rigid amidino-phenylalanine derivatives as inhibitors of thrombin. Journal of enzyme inhibition, 1995, Volume: 9, Issue:1 Topics: Animals; Antithrombins; Benzamidines; Binding Sites; Binding, Competitive; Crystallography, X-Ray; Dipeptides; Drug Design; Hydrogen Bonding; Lactams; Molecular Structure; Piperidines; Pyrrolidinones; Rats; Serine Proteinase Inhibitors; Thrombin; Trypsin	1995
Structure-activity relationships of inhibitors derived from 3-amidinophenylalanine. Journal of enzyme inhibition, 1995, Volume: 9, Issue:1 Topics: Amidines; Animals; Antithrombins; Cattle; Crystallography, X-Ray; Dipeptides; Factor Xa Inhibitors; Molecular Structure; Piperidines; Serine Proteinase Inhibitors; Stereoisomerism; Structure-Activity Relationship; Thrombin	1995
Functionality map analysis of the active site cleft of human thrombin. Journal of computer-aided molecular design, 1996, Volume: 10, Issue:1 Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Arginine; Binding Sites; Dipeptides; Humans; Models, Molecular; Molecular Probes; Molecular Sequence Data; Molecular Structure; Pipecolic Acids; Piperidines; Protein Conformation; Serine Proteinase Inhibitors; Software; Sulfonamides; Thrombin	1996
A comparison of heuristic search algorithms for molecular docking. Journal of computer-aided molecular design, 1997, Volume: 11, Issue:3 Topics: Algorithms; Arginine; Azepines; Binding Sites; Computer Simulation; Dipeptides; HIV Protease; Ligands; Macromolecular Substances; Methotrexate; Models, Molecular; Neuraminidase; Pipecolic Acids; Piperidines; Protein Binding; Software Design; Structure-Activity Relationship; Sulfonamides; Tetrahydrofolate Dehydrogenase; Thermodynamics; Thrombin	1997
Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine. Journal of medicinal chemistry, 1997, Sep-12, Volume: 40, Issue:19 Topics: Animals; Antithrombins; Binding Sites; Blood Coagulation; Crystallography, X-Ray; Dipeptides; Factor Xa Inhibitors; Fibrinolysin; Humans; Indicators and Reagents; Metabolic Clearance Rate; Phenylalanine; Piperazines; Piperidines; Protease Inhibitors; Prothrombin Time; Rats; Stereoisomerism; Structure-Activity Relationship; Thrombin; Trypsin	1997
Inhibition of thrombin generation in plasma by inhibitors of factor Xa. Thrombosis and haemostasis, 1997, Volume: 78, Issue:4 Topics: Animals; Anticoagulants; Arginine; Arthropod Proteins; Cattle; Dipeptides; Factor Xa; Factor Xa Inhibitors; Fibrinolytic Agents; Hirudins; Humans; Intercellular Signaling Peptides and Proteins; Kinetics; Molecular Structure; Naphthalenes; Partial Thromboplastin Time; Peptides; Pipecolic Acids; Piperidines; Propionates; Rabbits; Recombinant Proteins; Serine Proteinase Inhibitors; Sulfonamides; Sulfones; Thrombin; Thromboplastin	1997
Flexible docking using Tabu search and an empirical estimate of binding affinity. Proteins, 1998, Nov-15, Volume: 33, Issue:3 Topics: Algorithms; Computer-Aided Design; Dipeptides; Drug Design; Ligands; Models, Molecular; Piperidines; Protein Conformation; Receptors, Drug; Thrombin	1998
The mechanism of binding of low-molecular-weight active site inhibitors to human alpha-thrombin. Journal of enzyme inhibition, 1998, Volume: 13, Issue:1 Topics: Antithrombins; Area Under Curve; Arginine; Azetidines; Benzylamines; Binding Sites; Dipeptides; Fluorescence; Glycine; Humans; Kinetics; Molecular Weight; Pipecolic Acids; Piperidines; Spectrometry, Fluorescence; Spectrophotometry; Sulfonamides; Thrombin	1998
1-Aminoisoquinoline as benzamidine isoster in the design and synthesis of orally active thrombin inhibitors. Bioorganic & medicinal chemistry letters, 1999, Mar-08, Volume: 9, Issue:5 Topics: Administration, Oral; Anticoagulants; Benzamidines; Caco-2 Cells; Dipeptides; Drug Design; Humans; Isoquinolines; Piperidines; Thrombin; Trypsin Inhibitors	1999
The particle concept: placing discrete water molecules during protein-ligand docking predictions. Proteins, 1999, Jan-01, Volume: 34, Issue:1 Topics: Algorithms; Arabinose; Computer Simulation; Dipeptides; HIV Protease; Kinetics; Ligands; Models, Chemical; Models, Molecular; Piperidines; Protein Binding; Temperature; Thrombin; Trypsinogen; Water	1999
Structure-based design and synthesis of novel thrombin inhibitors based on phosphinic peptide mimetics. Bioorganic & medicinal chemistry letters, 1999, Jul-19, Volume: 9, Issue:14 Topics: Antithrombins; Binding Sites; Computer Simulation; Dipeptides; Drug Design; Inhibitory Concentration 50; Models, Molecular; Molecular Mimicry; Peptides; Phosphinic Acids; Piperidines; Structure-Activity Relationship; Thrombin	1999
Design and synthesis of a novel synthetic NAPAP-penta-saccharide conjugate displaying a dual antithrombotic action. Bioorganic & medicinal chemistry letters, 1999, Jul-19, Volume: 9, Issue:14 Topics: Animals; Antithrombins; Carbohydrate Sequence; Dipeptides; Drug Design; Factor Xa Inhibitors; Half-Life; Heparin; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Sequence Data; Oligosaccharides; Piperidines; Rats; Solubility; Thrombin	1999
Two-stage method for protein-ligand docking. Journal of medicinal chemistry, 1999, Oct-21, Volume: 42, Issue:21 Topics: Algorithms; Antithrombins; Dipeptides; Drug Design; Inositol Phosphates; Ligands; Models, Molecular; Molecular Structure; Phosphoric Monoester Hydrolases; Piperidines; Proteins; Thrombin	1999
Hydrophobicity at the surface of proteins. Proteins, 1999, Dec-01, Volume: 37, Issue:4 Topics: Alkyl and Aryl Transferases; Annexin A2; Binding Sites; Dipeptides; DNA; DNA-Binding Proteins; Farnesyltranstransferase; Homeodomain Proteins; Macromolecular Substances; Models, Molecular; Nuclear Proteins; Peptides; Piperidines; Polyisoprenyl Phosphates; Pre-B-Cell Leukemia Transcription Factor 1; Protein Binding; Protein Conformation; Protein Structure, Quaternary; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; S100 Proteins; Sesquiterpenes; Static Electricity; Surface Properties; Thermodynamics; Thrombin; Tumor Suppressor Protein p53	1999
Thrombin attenuation is neuroprotective in the injured rat optic nerve. Journal of neurochemistry, 2001, Volume: 76, Issue:3 Topics: Administration, Topical; Animals; Antithrombins; Dipeptides; Nerve Crush; Nerve Degeneration; Neuroprotective Agents; Optic Nerve; Optic Nerve Injuries; Piperidines; Prothrombin; Rats; Rats, Wistar; Thrombin	2001
DOCK 4.0: search strategies for automated molecular docking of flexible molecule databases. Journal of computer-aided molecular design, 2001, Volume: 15, Issue:5 Topics: Algorithms; Binding Sites; Computer Simulation; Crystallography, X-Ray; Databases as Topic; Dipeptides; Drug Design; Models, Molecular; Molecular Conformation; Piperidines; Software; Software Design; Thermodynamics; Trypsin	2001
Structure-activity relationships of new NAPAP-analogs. Journal of enzyme inhibition, 2001, Volume: 16, Issue:3 Topics: Animals; Antithrombins; Bile; Dipeptides; Female; Glycine; Molecular Structure; Piperidines; Rats; Rats, Wistar; Structure-Activity Relationship; Thrombin; Time Factors	2001
Structure-activity relationships of new NAPAP-analogs. Journal of enzyme inhibition and medicinal chemistry, 2002, Volume: 17, Issue:2 Topics: Antithrombins; Dipeptides; Factor Xa Inhibitors; Fibrinolysin; Kinetics; Molecular Structure; Piperidines; Protease Inhibitors; Pteridines; Sensitivity and Specificity; Structure-Activity Relationship; Trypsin Inhibitors	2002
Thrombin induces in vivo degeneration of nigral dopaminergic neurones along with the activation of microglia. Journal of neurochemistry, 2003, Volume: 84, Issue:5 Topics: Animals; Antithrombins; Corpus Striatum; Dipeptides; Dopamine; Dose-Response Relationship, Drug; Enzyme Induction; Female; In Situ Hybridization; Interleukin-1; Microglia; Microinjections; Neurodegenerative Diseases; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Piperidines; Rats; Rats, Wistar; RNA, Messenger; Substantia Nigra; Thrombin; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase	2003
[On a new analgesic principle (NAPAP, Lonarid)]. Die Medizinische Welt, 1962, Apr-07, Volume: 14 Topics: Acetanilides; Analgesics; Dipeptides; Piperidines	1962
The use of local surface properties for molecular superimposition. Journal of molecular modeling, 2008, Volume: 14, Issue:9 Topics: Amino Acid Chloromethyl Ketones; Anti-HIV Agents; Anticoagulants; Antimetabolites, Antineoplastic; Crystallography, X-Ray; Dipeptides; Folic Acid; HIV Protease Inhibitors; Humans; Imidazoles; Ligands; Methotrexate; Models, Molecular; Molecular Structure; Piperidines; Protein Binding; Proteins; Quinoxalines; Reverse Transcriptase Inhibitors; Software; Static Electricity; Structure-Activity Relationship; Sulfur Compounds; Surface Properties; Tetrahydrofolate Dehydrogenase	2008
A Novel Highly Sensitive Method for Measuring Inflammatory Neural-Derived APC Activity in Glial Cell Lines, Mouse Brain and Human CSF. International journal of molecular sciences, 2020, Mar-31, Volume: 21, Issue:7 Topics: Animals; Brain; Brain Concussion; Cell Line; Cerebrospinal Fluid; Dipeptides; Endothelial Protein C Receptor; Humans; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Models, Animal; Neuroglia; Piperidines; Protein C; Pyrazoles; Pyridones; Receptor, PAR-1; Thrombin	2020