n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide has been researched along with arginine in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 10 (90.91) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bode, W; Brandstetter, H; Edwards, BF; Grosse, D; Hoeffken, HW; Martin, PD; Stürzebecher, J; Turk, D | 1 |
| Banner, DW; Hadváry, P | 2 |
| Bode, W; Stürzebecher, J; Turk, D | 1 |
| Hoffmann, J; Markwardt, F; Nowak, G | 1 |
| Claeson, G; Ehrhardt, C; Metternich, R; Scully, MF; Stone, SR; Tapparelli, C; Zurini, M | 1 |
| Grootenhuis, PD; Karplus, M | 1 |
| Clark, DE; Murray, CW; Westhead, DR | 1 |
| Prasa, D; Stürzebecher, J; Svendsen, L | 1 |
| Naylor-Olsen, AM; Sanderson, PE | 1 |
| Deinum, J; Nilsson, T; Sjöling-Ericksson, A | 1 |
2 review(s) available for n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide and arginine
| Article | Year |
|---|---|
Inhibitor binding to thrombin: x-ray crystallographic studies.
Topics: Amino Acid Sequence; Antithrombins; Arginine; Binding Sites; Crystallography, X-Ray; Dipeptides; Hirudins; Molecular Sequence Data; Molecular Structure; Pipecolic Acids; Piperidines; Sulfonamides; Thrombin | 1993 |
Thrombin inhibitor design.
Topics: Anticoagulants; Antithrombins; Arginine; Binding Sites; Dipeptides; Drug Design; Humans; Models, Molecular; Oligopeptides; Pipecolic Acids; Piperidines; Platelet Aggregation Inhibitors; Structure-Activity Relationship; Sulfonamides; Thrombin | 1998 |
9 other study(ies) available for n(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide and arginine
| Article | Year |
|---|---|
Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics.
Topics: Amidines; Amino Acid Sequence; Animals; Antithrombins; Arginine; Benzamidines; Binding Sites; Cattle; Crystallography; Dipeptides; Fibrinolytic Agents; Hydrogen Bonding; Ligands; Models, Molecular; Molecular Sequence Data; Pipecolic Acids; Piperidines; Protein Conformation; Structure-Activity Relationship; Sulfonamides; Thrombin | 1992 |
Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors.
Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Arginine; Benzamidines; Binding Sites; Dipeptides; Humans; Models, Molecular; Pipecolic Acids; Piperidines; Stereoisomerism; Sulfonamides; Thrombin; Trypsin | 1991 |
Geometry of binding of the benzamidine- and arginine-based inhibitors N alpha-(2-naphthyl-sulphonyl-glycyl)-DL-p-amidinophenylalanyl-pipe ridine (NAPAP) and (2R,4R)-4-methyl-1-[N alpha-(3-methyl-1,2,3,4-tetrahydro-8- quinolinesulphonyl)-L-arginyl]-2-piper
Topics: Animals; Antithrombins; Arginine; Binding Sites; Cattle; Computer Graphics; Crystallography; Dipeptides; Humans; In Vitro Techniques; Models, Molecular; Models, Structural; Molecular Conformation; Pipecolic Acids; Piperidines; Protein Binding; Structure-Activity Relationship; Sulfonamides; Thrombin; Trypsin; Trypsin Inhibitors; X-Ray Diffraction | 1990 |
Comparative studies on thrombin inhibitors in experimental microthrombosis.
Topics: 4-Aminobenzoic Acid; Animals; Arginine; Dipeptides; Female; Fibrinogen; Hirudins; Kinetics; Lung; Male; Microcirculation; para-Aminobenzoates; Piperidines; Rats; Rats, Inbred Strains; Thrombin; Thrombosis | 1983 |
In vitro and in vivo characterization of a neutral boron-containing thrombin inhibitor.
Topics: Animals; Antithrombins; Arginine; Blood Coagulation Tests; Boron; Bridged Bicyclo Compounds; Cells, Cultured; Dipeptides; Hirudins; Humans; Kinetics; Male; Oligopeptides; Pipecolic Acids; Piperidines; Platelet Activation; Platelet Aggregation; Rats; Rats, Wistar; Sulfonamides; Thrombin | 1993 |
Functionality map analysis of the active site cleft of human thrombin.
Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Arginine; Binding Sites; Dipeptides; Humans; Models, Molecular; Molecular Probes; Molecular Sequence Data; Molecular Structure; Pipecolic Acids; Piperidines; Protein Conformation; Serine Proteinase Inhibitors; Software; Sulfonamides; Thrombin | 1996 |
A comparison of heuristic search algorithms for molecular docking.
Topics: Algorithms; Arginine; Azepines; Binding Sites; Computer Simulation; Dipeptides; HIV Protease; Ligands; Macromolecular Substances; Methotrexate; Models, Molecular; Neuraminidase; Pipecolic Acids; Piperidines; Protein Binding; Software Design; Structure-Activity Relationship; Sulfonamides; Tetrahydrofolate Dehydrogenase; Thermodynamics; Thrombin | 1997 |
Inhibition of thrombin generation in plasma by inhibitors of factor Xa.
Topics: Animals; Anticoagulants; Arginine; Arthropod Proteins; Cattle; Dipeptides; Factor Xa; Factor Xa Inhibitors; Fibrinolytic Agents; Hirudins; Humans; Intercellular Signaling Peptides and Proteins; Kinetics; Molecular Structure; Naphthalenes; Partial Thromboplastin Time; Peptides; Pipecolic Acids; Piperidines; Propionates; Rabbits; Recombinant Proteins; Serine Proteinase Inhibitors; Sulfonamides; Sulfones; Thrombin; Thromboplastin | 1997 |
The mechanism of binding of low-molecular-weight active site inhibitors to human alpha-thrombin.
Topics: Antithrombins; Area Under Curve; Arginine; Azetidines; Benzylamines; Binding Sites; Dipeptides; Fluorescence; Glycine; Humans; Kinetics; Molecular Weight; Pipecolic Acids; Piperidines; Spectrometry, Fluorescence; Spectrophotometry; Sulfonamides; Thrombin | 1998 |