Page last updated: 2024-09-03

n(8)-acetylspermidine and spermidine

n(8)-acetylspermidine has been researched along with spermidine in 43 studies

Compound Research Comparison

Studies (n(8)-acetylspermidine)	Trials (n(8)-acetylspermidine)	Recent Studies (post-2010) (n(8)-acetylspermidine)	Studies (spermidine)	Trials (spermidine)	Recent Studies (post-2010) (spermidine)
46	0	5	5,643	28	1,281

Protein Interaction Comparison

Protein	Taxonomy	n(8)-acetylspermidine (IC50)	spermidine (IC50)
Pyruvate kinase PKM	Homo sapiens (human)		1.41

Research

Studies (43)

Timeframe	Studies, this research(%)	All Research%
pre-1990	23 (53.49)	18.7374
1990's	13 (30.23)	18.2507
2000's	2 (4.65)	29.6817
2010's	4 (9.30)	24.3611
2020's	1 (2.33)	2.80

Authors

Authors	Studies
Müller, S; Shukla, OP; Walter, RD	1
Callery, PS; Egorin, MJ; Snyder, SW	1
Carper, SW; Gerner, EW; Manning, KA; Willis, DG	1
Creutzfeldt, W; Fölsch, UR; Löser, C; Paprotny, C	1
Haukanes, BI; Helland, DE; Szajko, K	1
Almeida, S; Grehn, L; Lurdes, M; Ragnarsson, U	1
Hyvönen, T	1
Blankenship, JW; Dredar, SA; Fries, DS; Manneh, V; Marchant, PE	1
Alshabanah, O; Blankenship, J; Dredar, S; Fries, D; Manneh, V; Marchant, P; Matthews, H	1
Brasitus, TA; Dudeja, PK; Halline, AG; Lashner, BA	1
Ekström, J; Månsson, B; Nilsson, BO; Rosengren, E; Tobin, G	1
Blankenship, JW; Matthews, HR; Morgan, JE	2
Carati, D; Rossoni, C; Stefanelli, C	1
Bloomfield, VA; Canellakis, ZN; Thomas, TJ	1
Kingsnorth, AN; Wallace, HM	1
Kobayashi, T; Makita, M; Suemoto, Y; Yamamoto, S	1
Blankenship, J; Marchant, PE	2
Della Ragione, F; Pegg, AE	1
Abdel-Monem, MM; Hrushesky, WJ; Merdink, J	1
Joder-Ohlenbusch, AM; Mamont, PS; Siat, M	1
Davis, TP; Ellingson, JD; Russell, DH	1
Brendel, K; Prussak, CE	1
Abdel-Monem, MM; Merdink, JL; Theologides, A	1
Blankenship, J; Santacroce, MJ	1
Kataoka, H; Makita, M; Wakamatsu, K; Yamamoto, S; Yokogawa, M	1
Abdel-Monem, MM; Merdink, JL	1
Blankenship, J; Fries, D; Wang, Z	2
Brasitus, TA; Halline, AG; Hankewych, M; Jacoby, R; McCormick, D; O'Brien, BL	1
Broglia, E; Perin, A; Sessa, A; Terreni, MR	1
Chan, CF; Jiang, MJ; Wing, LY	1
Evans, DM; Wallace, HM	1
Blankenship, J	1
Berry, MD	1
Blankenship, J; Fries, D; Menezes, A; Mudumba, S	1
Cetto, M; Jahn, B; Jauch, KW; Thasler, WE; Weiss, TS	1
Bowman, CM; Christianson, DW; Decroos, C	1
Ashbeck, EL; Gerner, EW; Thompson, PA; Thomson, CA; Vargas, AJ	1
Abela, L; Baumer, A; Crowther, LM; Joset, P; Mastrangelo, M; Mathis, D; Papuc, M; Plecko, B; Rauch, A; Schmitt, B; Simmons, L; Steindl, K; Sticht, H	1
Christianson, DW; Herbst-Gervasoni, CJ	2

Other Studies

43 other study(ies) available for n(8)-acetylspermidine and spermidine

Article	Year
Polyamine oxidase from Acanthamoeba culbertsoni specific for N8-acetylspermidine. Molecular and biochemical parasitology, 1992, Volume: 51, Issue:1 Topics: Acanthamoeba; Animals; Diamines; Hydrogen-Ion Concentration; Osmolar Concentration; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Spermidine; Substrate Specificity; Temperature	1992
Induction of human leukemia cell differentiation by regiospecifically acetylated spermidines. Biochemical and biophysical research communications, 1991, Oct-31, Volume: 180, Issue:2 Topics: Cell Differentiation; Cell Division; Cell Line; Dose-Response Relationship, Drug; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Spermidine; Structure-Activity Relationship	1991
Spermidine acetylation in response to a variety of stresses in Escherichia coli. The Journal of biological chemistry, 1991, Jul-05, Volume: 266, Issue:19 Topics: Acetylation; Cold Temperature; Escherichia coli; Ethanol; Genes, Bacterial; Hot Temperature; Mutation; Spermidine	1991
Polyamines in colorectal cancer. Evaluation of polyamine concentrations in the colon tissue, serum, and urine of 50 patients with colorectal cancer. Cancer, 1990, Feb-15, Volume: 65, Issue:4 Topics: Antigens, Tumor-Associated, Carbohydrate; Cadaverine; Carcinoembryonic Antigen; Colon; Colonic Neoplasms; Female; Humans; Male; Middle Aged; Polyamines; Putrescine; Rectal Neoplasms; Spermidine; Spermine	1990
Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNA. FEBS letters, 1990, Sep-03, Volume: 269, Issue:2 Topics: Apurinic Acid; Base Sequence; DNA; Hydrolysis; Models, Structural; Molecular Sequence Data; Plasmids; Polynucleotides; Spermidine	1990
Facile synthesis of monoacetylated spermidines, illustrating selective deacetylation and application of a common precursor. Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 1989, Volume: 43, Issue:10 Topics: Dealkylation; Indicators and Reagents; Spermidine	1989
Excretion of acetylated and free polyamines by polyamine depleted Chinese hamster ovary cells. The International journal of biochemistry, 1989, Volume: 21, Issue:3 Topics: Animals; Biogenic Polyamines; Cell Division; Cell Line; Eflornithine; Putrescine; Spermidine; Spermine	1989
Design and synthesis of inhibitors of N8-acetylspermidine deacetylase. Journal of medicinal chemistry, 1989, Volume: 32, Issue:5 Topics: Amidohydrolases; Animals; Binding Sites; Drug Design; Male; Rats; Rats, Inbred Strains; Spermidine; Structure-Activity Relationship	1989
A selective inhibitor of N8-acetylspermidine deacetylation in mice and HeLa cells without effects on histone deacetylation. Archives of biochemistry and biophysics, 1989, Aug-15, Volume: 273, Issue:1 Topics: Acetylation; Amidohydrolases; Animals; Chromatography, High Pressure Liquid; Densitometry; Diamines; HeLa Cells; Histones; Humans; Liver; Male; Mice; Putrescine; Spermidine; Spleen	1989
Urinary excretion of N1-acetylspermidine and other acetylated and free polyamines in the 1,2-dimethylhydrazine model of experimental rat colon cancer. Cancer research, 1989, Sep-01, Volume: 49, Issue:17 Topics: 1,2-Dimethylhydrazine; Acetylation; Animals; Biogenic Polyamines; Biomarkers, Tumor; Colonic Neoplasms; Dimethylhydrazines; Male; Predictive Value of Tests; Putrescine; Rats; Spermidine; Spermine	1989
Receptors involved in the nervous system regulation of polyamine metabolism in rat salivary glands. Acta physiologica Scandinavica, 1989, Volume: 135, Issue:3 Topics: Animals; Atropine; Dihydroergotamine; Male; Ornithine Decarboxylase; Parasympathetic Nervous System; Phentolamine; Propranolol; Putrescine; Rats; Rats, Inbred Strains; Salivary Glands; Spermidine; Spermine; Sympathetic Nervous System; Yohimbine	1989
Thermal denaturation of mononucleosomes in the presence of spermine, spermidine, N1-acetylspermidine, N8-acetylspermidine or putrescine: implications for chromosome structure. Molecular biology reports, 1987, Volume: 12, Issue:1 Topics: Acetylation; Animals; DNA; Hot Temperature; Nucleic Acid Denaturation; Nucleosomes; Polyamines; Putrescine; Rats; Spermidine; Spermine	1987
Separation of N1- and N8-acetylspermidine isomers by reversed-phase column liquid chromatography after derivatization with dansyl chloride. Journal of chromatography, 1986, Feb-14, Volume: 375, Issue:1 Topics: Animals; Chromatography, High Pressure Liquid; Dansyl Compounds; Isomerism; Liver; Lung; Putrescine; Rats; Spermidine; Spleen	1986
Association constants for the interaction of double-stranded and single-stranded DNA with spermine, spermidine, putrescine, diaminopropane, N1- and N8-acetylspermidine, and magnesium: determination from analysis of the broadening of thermal denaturation c Archives of biochemistry and biophysics, 1986, Volume: 246, Issue:1 Topics: Animals; Cattle; Diamines; DNA; DNA, Single-Stranded; Electronic Data Processing; Hot Temperature; Ligands; Magnesium; Nucleic Acid Denaturation; Polyamines; Putrescine; Spermidine; Spermine; Thymus Gland	1986
Differential effects on the B-to-Z transition of poly(dG-me5dC).poly(dG-me5dC) produced by N1- and N8-acetyl spermidine. Biopolymers, 1985, Volume: 24, Issue:4 Topics: Nucleic Acid Conformation; Nucleic Acid Denaturation; Polydeoxyribonucleotides; Spermidine	1985
Elevation of monoacetylated polyamines in human breast cancers. European journal of cancer & clinical oncology, 1985, Volume: 21, Issue:9 Topics: Breast Neoplasms; Female; Humans; Polyamines; Prognosis; Putrescine; Spermidine; Spermine	1985
An improved gas chromatographic method for the determination of urinary acetylpolyamines. Chemical & pharmaceutical bulletin, 1984, Volume: 32, Issue:5 Topics: Adult; Chromatography, Gas; Female; Humans; Male; Polyamines; Putrescine; Spermidine	1984
Metabolism of N1-acetylspermidine and N8-acetylspermidine in rats. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1984, Volume: 177, Issue:1 Topics: Animals; Chromatography, High Pressure Liquid; Kidney; Liver; Male; Models, Biological; Rats; Rats, Inbred Strains; Spermidine; Time Factors	1984
Studies of the specificity and kinetics of rat liver spermidine/spermine N1-acetyltransferase. The Biochemical journal, 1983, Sep-01, Volume: 213, Issue:3 Topics: Acetylation; Acetyltransferases; Animals; Coenzyme A; Kinetics; Liver; Rats; Spermidine; Substrate Specificity	1983
Circadian rhythmicity of polyamine urinary excretion. Cancer research, 1983, Volume: 43, Issue:8 Topics: Circadian Rhythm; Female; Humans; Male; Polyamines; Putrescine; Spermidine; Spermine	1983
Metabolism of N8-monoacetylspermidine in rat hepatoma cells. Investigation of its effect on the activity of L-ornithine decarboxylase. European journal of biochemistry, 1983, Jul-01, Volume: 133, Issue:3 Topics: Amidohydrolases; Animals; Carboxy-Lyases; Cells, Cultured; Enzyme Activation; Liver Neoplasms, Experimental; Ornithine Decarboxylase; Rats; Spermidine	1983
Analysis of polyamines and acetyl derivatives by a single automated amino acid analyzer technique. Journal of chromatography, 1983, Apr-08, Volume: 273, Issue:2 Topics: Autoanalysis; Chromatography, Ion Exchange; Female; Fluorescence; Humans; Hydrogen-Ion Concentration; Liver; Male; Ovarian Neoplasms; Putrescine; Spermidine	1983
The formation of radiolabeled N1- and N8-acetylspermidine in various rat organs following [14C]spermidine administration. The International journal of biochemistry, 1983, Volume: 15, Issue:7 Topics: Animals; Chromatography, High Pressure Liquid; Female; Injections, Intravenous; Kidney; Liver; Lung; Pancreas; Rats; Rats, Inbred Strains; Spermidine; Tissue Distribution	1983
N1-acetylspermidine and N6-acetylspermidine in normal rat tissues and body fluids. Proceedings of the Western Pharmacology Society, 1983, Volume: 26 Topics: Animals; Body Fluids; Male; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine	1983
Urinary excretion of monoacetyl polyamines in patients with non-Hodgkin's lymphoma. Cancer research, 1982, Volume: 42, Issue:5 Topics: Chromatography, High Pressure Liquid; Humans; Lymphoma; Polyamines; Spermidine; Time Factors	1982
Inhibition of acetylspermidine deacetylating activity from rat liver. Proceedings of the Western Pharmacology Society, 1982, Volume: 25 Topics: Animals; Cytosol; Dealkylation; Kinetics; Liver; Male; Rats; Rats, Inbred Strains; Spermidine	1982
Gas chromatographic method for the determination of urinary acetylpolyamines. Journal of chromatography, 1982, Dec-10, Volume: 233 Topics: Adult; Cadaverine; Chromatography, Gas; Chromatography, Gel; Formates; Formic Acid Esters; Humans; Middle Aged; Polyamines; Putrescine; Spermidine	1982
Determination of monoacetyldiamines and -polyamines in urine by high-performance liquid chromatography. Journal of chromatography, 1981, Mar-13, Volume: 222, Issue:3 Topics: Chromatography, High Pressure Liquid; Dansyl Compounds; Humans; Neoplasms; Putrescine; Reference Values; Spermidine	1981
Similarity of effects of N8-acetylspermidine and its deacetylase inhibitor on stimulating the growth of L1210 cells. Proceedings of the Western Pharmacology Society, 1995, Volume: 38 Topics: Amidohydrolases; Animals; Biogenic Polyamines; Cell Division; Diamines; Leukemia L1210; Mice; Spermidine; Tumor Cells, Cultured	1995
Urinary N1-acetylspermidine and N8-acetylspermidine excretion in normal humans and in patients with colorectal cancer. Digestive diseases and sciences, 1995, Volume: 40, Issue:6 Topics: Adenocarcinoma; Adult; Chromatography, High Pressure Liquid; Circadian Rhythm; Colorectal Neoplasms; Female; Humans; Linear Models; Male; Middle Aged; Reference Values; ROC Curve; Sensitivity and Specificity; Spermidine	1995
Spermidine acetylation in N1 and N8 position in rat brain and in N-ethyl-N-nitrosourea-induced gliomas. Cancer letters, 1994, Jan-30, Volume: 76, Issue:2-3 Topics: Acetylation; Acetyltransferases; Animals; Brain; Brain Neoplasms; Catalysis; Cytosol; Ethylnitrosourea; Female; Glioma; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Spermidine	1994
Acetylpolyamines decrease blood pressure, [Ca++]i and isometric force of vascular smooth muscle. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:1 Topics: Animals; Aorta, Thoracic; Blood Pressure; Calcium; Depression, Chemical; Hypotension; In Vitro Techniques; Intracellular Fluid; Isometric Contraction; Male; Muscle, Smooth, Vascular; Polyamines; Rats; Rats, Sprague-Dawley; Spermidine; Spermine; Tail	1993
Measurement of spermidine/spermine N1-acetyltransferase activity. Methods in molecular biology (Clifton, N.J.), 1998, Volume: 79 Topics: Acetyl Coenzyme A; Acetyltransferases; Chromatography, High Pressure Liquid; Humans; Scintillation Counting; Spermidine; Tritium	1998
Assay of N8-acetylspermidine deacetylase. Methods in molecular biology (Clifton, N.J.), 1998, Volume: 79 Topics: Acetic Acid; Amidohydrolases; Animals; Cytoplasm; Liver; Rats; Scintillation Counting; Spermidine; Tritium	1998
N8-acetyl spermidine protects rat cerebellar granule cells from low K+-induced apoptosis. Journal of neuroscience research, 1999, Feb-01, Volume: 55, Issue:3 Topics: Animals; Animals, Newborn; Apoptosis; Cells, Cultured; Cerebellum; Cytarabine; Immunosuppressive Agents; Neurons; Potassium; Rats; Rats, Wistar; Spermidine; Spermine	1999
Effect of N8-acetylspermidine deacetylase inhibition on the growth of L1210 cells. Biochemical pharmacology, 1999, May-15, Volume: 57, Issue:10 Topics: Amidohydrolases; Animals; Cell Division; Chromatography, High Pressure Liquid; Diamines; Drug Interactions; Enzyme Inhibitors; Leukemia L1210; Mice; Polyamines; Putrescine; Spermidine; Spermine	1999
Differentiation of PC12 cells induced by N8-acetylspermidine and by N8-acetylspermidine deacetylase inhibition. Biochemical pharmacology, 2002, Jun-01, Volume: 63, Issue:11 Topics: Amidohydrolases; Animals; Cell Differentiation; Cell Size; Dexamethasone; Dopamine; Drug Interactions; Nerve Growth Factor; PC12 Cells; Polyamines; Rats; Spermidine	2002
Collagen sandwich culture affects intracellular polyamine levels of human hepatocytes. Cell proliferation, 2002, Volume: 35, Issue:5 Topics: Biogenic Polyamines; Cell Culture Techniques; Cell Differentiation; Cell Division; Cells, Cultured; Collagen; Extracellular Matrix; Hepatocytes; Humans; Putrescine; Spermidine; Spermine; Time Factors	2002
Synthesis and evaluation of N⁸-acetylspermidine analogues as inhibitors of bacterial acetylpolyamine amidohydrolase. Bioorganic & medicinal chemistry, 2013, Aug-01, Volume: 21, Issue:15 Topics: Aminohydrolases; Polyamines; Spermidine	2013
Dietary polyamine intake and polyamines measured in urine. Nutrition and cancer, 2014, Volume: 66, Issue:7 Topics: Aged; Aged, 80 and over; Anthropometry; Colorectal Neoplasms; Cross-Sectional Studies; Diet; Energy Intake; Folic Acid; Humans; Male; Middle Aged; Nutrition Assessment; Pilot Projects; Polyamines; Reproducibility of Results; Spermidine; Surveys and Questionnaires	2014
N(8)-acetylspermidine as a potential plasma biomarker for Snyder-Robinson syndrome identified by clinical metabolomics. Journal of inherited metabolic disease, 2016, Volume: 39, Issue:1 Topics: Adolescent; Biomarkers; Case-Control Studies; Child; Child, Preschool; Exome; Female; Humans; Infant; Male; Mental Retardation, X-Linked; Metabolome; Metabolomics; Mutation, Missense; Pedigree; Plasma; Spermidine; Spermine Synthase	2016
Binding of Biochemistry, 2019, 12-10, Volume: 58, Issue:49 Topics: Acetylation; Animals; Binding Sites; Catalysis; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Histone Deacetylases; Polyamines; Protein Binding; Spermidine; Substrate Specificity; Zebrafish; Zebrafish Proteins; Zinc	2019
X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10. Biochemistry, 2021, 02-02, Volume: 60, Issue:4 Topics: Amino Acid Substitution; Animals; Catalytic Domain; Crystallography, X-Ray; Histone Deacetylases; Mutation, Missense; Putrescine; Spermidine; Zebrafish; Zebrafish Proteins	2021