n(7)-hydroxyethylguanine and clomesone

n(7)-hydroxyethylguanine has been researched along with clomesone* in 1 studies

Other Studies

1 other study(ies) available for n(7)-hydroxyethylguanine and clomesone

Article	Year
Identification of 7-(2-hydroxyethyl)guanine as a product of alkylation of calf thymus DNA with clomesone. Biochemical pharmacology, 1991, Feb-01, Volume: 41, Issue:3 Evidence at the molecular level is presented in support of alkylation of O6-guanine moieties of DNA as the mechanism of cytotoxicity of Clomesone to HT-29 cells and consists in the isolation and identification of a product resulting from alkylation of calf thymus DNA with Clomesone, followed by depurination to yield 7-(2-hydroxyethyl)guanine, whose formation is reasonably explained by O6-guanine chloroethylation followed by intramolecular alkylation at N7 of guanine and subsequent hydrolysis to the hydroxyethylguanine. Topics: Alkylation; Animals; Antineoplastic Agents; Cattle; Chromatography, High Pressure Liquid; DNA; Guanine; Hydrolysis; Mesylates; Methylation; Thymus Gland	1991

Article

Year

Identification of 7-(2-hydroxyethyl)guanine as a product of alkylation of calf thymus DNA with clomesone.

Biochemical pharmacology, 1991, Feb-01, Volume: 41, Issue:3

Evidence at the molecular level is presented in support of alkylation of O6-guanine moieties of DNA as the mechanism of cytotoxicity of Clomesone to HT-29 cells and consists in the isolation and identification of a product resulting from alkylation of calf thymus DNA with Clomesone, followed by depurination to yield 7-(2-hydroxyethyl)guanine, whose formation is reasonably explained by O6-guanine chloroethylation followed by intramolecular alkylation at N7 of guanine and subsequent hydrolysis to the hydroxyethylguanine.

Topics: Alkylation; Animals; Antineoplastic Agents; Cattle; Chromatography, High Pressure Liquid; DNA; Guanine; Hydrolysis; Mesylates; Methylation; Thymus Gland

1991