n(6)-cyclohexyladenosine and seglitide

n(6)-cyclohexyladenosine has been researched along with seglitide* in 1 studies

Other Studies

1 other study(ies) available for n(6)-cyclohexyladenosine and seglitide

Article	Year
Antagonist effects of seglitide (MK 678) at somatostatin receptors in guinea-pig isolated right atria. British journal of pharmacology, 1993, Volume: 109, Issue:4 Somatostatin (SS) exerts a negative inotropic effect in isolated atria. Here we report that in guinea-pig isolated right atria, seglitide, a potent cyclic hexapeptide somatostatin agonist, behaves as a competitive somatostatin receptor antagonist with pA2 values against SS14, SS25 and SS28, of 6.50 +/- 0.40, 6.24 +/- 0.08 and 6.09 +/- 0.06, respectively. Seglitide had little or no effect on the negative inotropic action of carbachol or N6-cyclohexyladenosine. Our findings indicate that the receptor-response coupling characteristics of guinea-pig atria are such that in this preparation seglitide has low intrinsic activity and behaves specifically as a somatostatin receptor antagonist. Topics: Adenosine; Animals; Carbachol; Guinea Pigs; Heart; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Peptides, Cyclic; Receptors, Somatostatin; Somatostatin	1993

Article

Year

Antagonist effects of seglitide (MK 678) at somatostatin receptors in guinea-pig isolated right atria.

British journal of pharmacology, 1993, Volume: 109, Issue:4

Somatostatin (SS) exerts a negative inotropic effect in isolated atria. Here we report that in guinea-pig isolated right atria, seglitide, a potent cyclic hexapeptide somatostatin agonist, behaves as a competitive somatostatin receptor antagonist with pA2 values against SS14, SS25 and SS28, of 6.50 +/- 0.40, 6.24 +/- 0.08 and 6.09 +/- 0.06, respectively. Seglitide had little or no effect on the negative inotropic action of carbachol or N6-cyclohexyladenosine. Our findings indicate that the receptor-response coupling characteristics of guinea-pig atria are such that in this preparation seglitide has low intrinsic activity and behaves specifically as a somatostatin receptor antagonist.

Topics: Adenosine; Animals; Carbachol; Guinea Pigs; Heart; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Peptides, Cyclic; Receptors, Somatostatin; Somatostatin

1993